NEUROGEN CORP
8-K, 2000-08-28
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                 ---------------


                                    FORM 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(d) OF THE

                         SECURITIES EXCHANGE ACT OF 1934



Date of Report (Date of earliest event reported)                 August 23, 2000



                              NEUROGEN CORPORATION
             (Exact name of registrant as specified in its charter)



          DELAWARE                  0-18311            22-2845714
(State or other jurisdiction      (Commission        (IRS Employer
      of incorporation)          File Number)      Identification No.)




35 Northeast Industrial Road, Branford, Connecticut                     06405
(Address of principal executive offices)                              (Zip Code)

Registrant's telephone number, including area code                (203) 488-8201






None
(Former name or former address, if changed since last report)


<PAGE>

Item 5.  Other Events

     On August 23, 2000,  Neurogen  Corporation  (the "Company")  announced that
Harry H. Penner, Jr., will step down as President and Chief Executive Officer of
the  Company.  A search has been  initiated  for a new CEO with a  comprehensive
scientific background in the pharmaceutical industry. Mr. Penner has stated that
he will stay on until the search for a new CEO has been completed.

SAFE HARBOR STATEMENT

     Statements which are not historical facts,  including  statements about the
Company's  confidence and strategies,  the status of various product development
programs,  the sufficiency of cash to fund planned  operations and the Company's
expectations concerning its development compounds,  drug discovery technologies,
opportunities  in the  pharmaceutical  marketplace  and  management  changes are
"forward  looking  statements"  within  the  meaning of the  Private  Securities
Litigations  Reform Act of 1995 that involve risks and uncertainties and are not
guarantees of future performance.  These risks include,  but are not limited to,
difficulties or delays in development,  testing, regulatory approval, production
and marketing of any of the Company's drug candidates, the failure to attract or
retain scientific management  personnel,  any unexpected adverse side effects or
inadequate  therapeutic  efficacy of the Company's drug  candidates  which could
slow or prevent product  development  efforts,  competition within the Company's
anticipated product markets, the Company's dependence on corporate partners with
respect  to  research   and   development   funding,   regulatory   filings  and
manufacturing and marketing expertise, the uncertainty of product development in
the pharmaceutical industry, inability to obtain sufficient funds through future
collaborative  arrangements,  equity  or debt  financings  or other  sources  to
continue  the  operation  of the  Company's  business,  risk  that  patents  and
confidentiality   agreements   will  not   adequately   protect  the   Company's
intellectual  property or trade secrets,  dependence  upon third parties for the
manufacture of potential  products,  inexperience in  manufacturing  and lack of
internal  manufacturing  capabilities,  dependence  on third  parties  to market
potential  products,  lack  of  sales  and  marketing  capabilities,   potential
unavailability   or  inadequacy  of  medical   insurance  or  other  third-party
reimbursement  for the cost of purchases of the  Company's  products,  and other
risks  detailed in the Company's  Securities  and Exchange  Commission  filings,
including its Annual  Report on Form 10-K for the year ended  December 31, 1999,
each of which could adversely affect the Company's  business and the accuracy of
the forward-looking statements contained herein.



                                   SIGNATURES

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                                    NEUROGEN CORPORATION
                                        ----------------------------------------
                                                       (Registrant)



      August 24, 2000                        /s/ Stephen R. Davis
--------------------------      ------------------------------------------------
         DATE                                Stephen R. Davis
                                Senior Vice President and Chief Business Officer





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