NEUROGEN CORP
3/A, 2000-02-24
PHARMACEUTICAL PREPARATIONS
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                UNITED STATES SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                     FORM 3

             INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

     Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

(Print or Type Responses)

1.   Name and Address of Reporting Person:

                    Thomas J. Tisch
                    667 Madison Avenue
                    New York, NY 10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                   ____    Director
                   ____    Officer (give title below)
                   _X__    10% Owner
                   ____    Other (specify below)
                   _______________________
<PAGE>


6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                  ____ Form filed by One Reporting Person
                  _X__ Form filed by More than One Reporting Person

             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  547,125

3.   Ownership Form:  Direct (D) or Indirect (I)

                  I

4.   Nature of Indirect Beneficial Ownership

                  (See explanation)

Table II - Derivative Securities Beneficially Owned (e.g., puts,calls, warrants,
                        options, convertible securities)

1.   Title of Derivative Security


2.   Date Exercisable and Expiration Date (Month/Day/Year)


         Date Exercisable


         Expiration Date




                                       2
<PAGE>


3.   Title and Amount of Securities Underlying Derivative Security

         Title



         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

Explanation of Responses:

              This Form 3 is being filed jointly by the following individuals
         and entities:

              1. Thomas J. Tisch;

              2. Daniel R. Tisch;

              3. James S. Tisch;

              4. Andrew H. Tisch (Thomas J. Tisch, Daniel R. Tisch, James S.
         Tisch and Andrew H. Tisch are referred to collectively as the "Messrs.
         Tisch");

              5. Four-Fourteen Partners, LLC, a Delaware limited liability
         company ("4-14P");

              6. Four Partners, a New York general partnership ("FP");

              7. The Thomas J. Tisch 1999 Annuity Trust II ("Thomas Tisch GRAT
         II");

              8. The Daniel R. Tisch 1999 Annuity Trust II ("Daniel Tisch GRAT
         II");

              9. The James S. Tisch 1999 Annuity Trust II ("James Tisch GRAT
         II");




                                       3
<PAGE>


              10. The Andrew H. Tisch 1999 Annuity Trust II ("Andrew Tisch GRAT
         II"; and collectively with Thomas Tisch GRAT II, Daniel Tisch GRAT II
         and James Tisch GRAT II, the "GRATs II");

              11. The Thomas J. Tisch 1999 Annuity Trust VI ("Thomas Tisch GRAT
         VI");

              12. The Daniel R. Tisch 1999 Annuity Trust VI ("Daniel Tisch GRAT
         VI");

              13. The James S. Tisch 1999 Annuity Trust VI ("James Tisch GRAT
         VI");

              14. The Andrew H. Tisch 1999 Annuity Trust VI ("Andrew Tisch GRAT
         VI"; and collectively with Thomas Tisch GRAT VI, Daniel Tisch GRAT VI
         and James Tisch GRAT VI, the "GRATs VI");

              15. The Thomas J. Tisch 2000 Annuity Trust IV ("Thomas Tisch 2000
         GRAT IV");

              16. The Daniel R. Tisch 2000 Annuity Trust IV ("Daniel Tisch 2000
         GRAT IV");

              17. The James S. Tisch 2000 Annuity Trust IV ("James Tisch 2000
         GRAT IV"); and

              18. The Andrew H. Tisch 2000 Annuity Trust IV ("Andrew Tisch 2000
         GRAT IV"; and collectively with Thomas Tisch 2000 GRAT IV, Daniel Tisch
         2000 GRAT IV and James Tisch 2000 GRAT IV, the "2000 GRATs IV" and
         collectively with the GRATs II and the GRATs VI, the "GRATs").

              Thomas J. Tisch, Andrew H. Tisch, Daniel R. Tisch, James S. Tisch,
         4-14P, FP, Andrew Tisch GRAT II, Daniel Tisch GRAT II, James Tisch GRAT
         II, Thomas Tisch GRAT II, Andrew Tisch GRAT VI, Daniel Tisch GRAT VI,
         James Tisch GRAT VI, Thomas Tisch GRAT VI, Andrew Tisch 2000 GRAT IV,
         Daniel Tisch 2000 GRAT IV, James Tisch 2000 GRAT IV, Thomas Tisch 2000
         GRAT IV are referred to herein individually as a "Reporting Person" and
         collectively as the "Reporting Persons."

              The members of 4-14P are trusts for the benefit of the offspring
         of the Messrs. Tisch, partnerships the partners of which are such
         trusts and partnerships the partners of which are such partnerships.
         The Messrs. Tisch serve as the trustees of such trusts. Thomas J. Tisch
         has been appointed the Manager of 4-14P.

              The sole partners of FP are Andrew H. Tisch 1991 Trust, for which
         Andrew H. Tisch is the managing trustee, Daniel R. Tisch 1991 Trust,
         for which




                                       4
<PAGE>


         Daniel R. Tisch is the managing trustee, James S. Tisch 1991 Trust, for
         which James S. Tisch is the managing trustee, and Thomas J. Tisch 1991
         Trust, for which Thomas J. Tisch is the managing trustee. Thomas J.
         Tisch has been appointed the Manager of FP.

              Each of the GRATs is a grantor retained annuity Trust in which the
         grantor holds an annuity interest and in which the remainder interest
         was created in favor of a trust or trusts for the grantor's offspring.
         Thomas J. Tisch is the grantor and Andrew H. Tisch is the trustee of
         Thomas Tisch GRAT II. Daniel R. Tisch is the grantor and James S. Tisch
         is the trustee of Daniel Tisch GRAT II. James S. Tisch is the grantor
         and Thomas J. Tisch is the trustee of James Tisch GRAT II. Andrew H.
         Tisch is the grantor and Daniel R. Tisch is the trustee of Andrew Tisch
         GRAT II. Thomas J. Tisch is the grantor and Andrew H. Tisch is the
         trustee of Thomas Tisch GRAT VI. Daniel R. Tisch is the grantor and
         James S. Tisch is the trustee of Daniel Tisch GRAT VI. James S. Tisch
         is the grantor and Thomas J. Tisch is the trustee of James Tisch GRAT
         VI. Andrew H. Tisch is the grantor and Daniel R. Tisch is the trustee
         of Andrew Tisch GRAT VI. Thomas J. Tisch is the grantor and Andrew H.
         Tisch is the trustee of Thomas Tisch 2000 GRAT IV. Daniel R. Tisch is
         the grantor and James S. Tisch is the trustee of Daniel Tisch 2000 GRAT
         IV. James S. Tisch is the grantor and Thomas J. Tisch is the trustee of
         James Tisch 2000 GRAT IV. Andrew H. Tisch is the grantor and Daniel R.
         Tisch is the trustee of Andrew Tisch 2000 GRAT IV.

              On February 4, 2000, each of the GRATs II distributed 62,685
         shares of common stock, $0.025 par value per share of Neurogen
         Corporation ("Common Stock") it owned to the respective grantor, who on
         February 10, 2000 contributed such Common Stock to the 2000 GRATs IV
         for which he is the grantor (the "GRATs II Distributions"). Also, on
         February 4, 2000, each of the GRATs VI distributed 25,557 shares of
         Common Stock it owned to the respective grantor, who on February 10,
         2000 contributed such Common Stock to the 2000 GRATs IV for which he is
         the grantor (the "GRATs VI Distributions").

              None of the GRATs II Distributions nor the GRATs VI Distributions
         was a "sale" for purposes of the Securities Act of 1933, as amended
         (the "Securities Act"), or the Securities Exchange Act of 1934, as
         amended (the "Exchange Act"), and collectively represented only a
         change in the form of beneficial ownership of the shares of Common
         Stock and not an actual change in the beneficial ownership of such
         shares of Common Stock.

              Each of the Messrs. Tisch is herein reporting beneficial ownership
         of the shares of Common Stock owned by the GRATs for which he is the
         Grantor.




                                       5
<PAGE>


              The filing of this statement is not an admission by any Reporting
         Person that such Reporting Person and any other person or persons
         constitute a "group" for purposes of Section 13(d)(3) of the Securities
         Exchange Act of 1934, as amended, or Rule 13d-5 thereunder or that any
         Reporting Person is the beneficial owner of any securities owned by any
         other person.

              Thomas J. Tisch is the designated filer.

              [Signatures follow all attachments]




                                       6
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00



Joint Filer Information

1.   Name and Address of Reporting Person:

                    Daniel R. Tisch
                    c/o Mentor Partners, LP
                    500 Park Avenue
                    New York, NY  10022

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                  ____   Director
                  ____   Officer (give title below)
                  __X_   10% Owner
                  ____   Other (specify below)
                  ______________________


6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                   ____   Form filed by One Reporting Person
                   __X_   Form filed by More than One Reporting Person




                                       7
<PAGE>


             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  547,125

3.   Ownership Form:  Direct (D) or Indirect (I)

                  I

4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)

 Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)


1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title




                                       8
<PAGE>

         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       9
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00



Joint Filer Information

1.   Name and Address of Reporting Person:

                    James S. Tisch
                    667 Madison Avenue
                    New York, NY  10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                  ____    Director
                  ____    Officer (give title below)
                  _X__    10% Owner
                  ____    Other (specify below)
                  ______________________


6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                   ____   Form filed by One Reporting Person
                   __X_   Form filed by More than One Reporting Person





                                       10
<PAGE>


             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  547,125

3.   Ownership Form:  Direct (D) or Indirect (I)

                  I

4.   Nature of Indirect Beneficial Ownership

     (See explanation to Form 3 of Thomas J. Tisch)


        Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)

1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title



         Amount or Number of Shares




                                       11
<PAGE>


4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]





                                       12
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00


Joint Filer Information

1.   Name and Address of Reporting Person:

                    Andrew H. Tisch
                    667 Madison Avenue
                    New York, NY  10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                   ____   Director
                   ____   Officer (give title below)
                   _X__   10% Owner
                   ____   Other (specify below)
                   ______________________


6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                    ____  Form filed by One Reporting Person
                    __X_  Form filed by More than One Reporting Person




                                       13
<PAGE>


             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  547,125

3.   Ownership Form:  Direct (D) or Indirect (I)

                  I

4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)

     Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)

1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title





                                       14
<PAGE>


         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       15
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00



Joint Filer Information

1.   Name and Address of Reporting Person:

                    Four-Fourteen Partners LLC
                    c/o Thomas J. Tisch
                    667 Madison Avenue
                    New York, NY  10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                  ____   Director
                  ____   Officer (give title below)
                  _X__   10% Owner
                  ____   Other (specify below)
                  ______________________


6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                   ____  Form filed by One Reporting Person
                   __X_  Form filed by More than One Reporting Person




                                       16
<PAGE>


             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  300,000

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D

4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)

     Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)

1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title




                                       17
<PAGE>


         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       18
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00



Joint Filer Information

1.   Name and Address of Reporting Person:

                    Four Partners
                    c/o Thomas J. Tisch
                    667 Madison Avenue
                    New York, NY  10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                  ____   Director
                  ____   Officer (give title below)
                  _X__   10% Owner
                  ____   Other (specify below)
                  _____________________

6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                  ____    Form filed by One Reporting Person
                  __X_    Form filed by More than One Reporting Person





                                       19
<PAGE>


             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  488,800

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D

4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)

     Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)

1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title





                                       20
<PAGE>


         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       21
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00



Joint Filer Information

1.   Name and Address of Reporting Person:

                    The Thomas J. Tisch 1999 Annuity Trust II
                    c/o Mr. Barry Bloom
                    655 Madison Avenue
                    New York, NY  10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                  ____    Director
                  ____    Officer (give title below)
                  _X__    10% Owner
                  ____    Other (specify below)


6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                   ____   Form filed by One Reporting Person
                   __X_   Form filed by More than One Reporting Person





                                       22
<PAGE>

             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  346,940

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D

4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)

     Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)

1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title




                                       23
<PAGE>

         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       24
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00



Joint Filer Information

1.   Name and Address of Reporting Person:

                    The Daniel R. Tisch 1999 Annuity Trust II
                    c/o Mr. Barry Bloom
                    655 Madison Avenue
                    New York, NY  10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                  ____    Director
                  ____    Officer (give title below)
                  _X__    10% Owner
                  ____    Other (specify below)
                  ______________________

6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                  ____    Form filed by One Reporting Person
                  _X__    Form filed by More than One Reporting Person





                                       25
<PAGE>


             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  346,940

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D

4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)

     Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)

1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title




                                       26
<PAGE>


         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       27
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00



Joint Filer Information

1.   Name and Address of Reporting Person:

                    The James S. Tisch 1999 Annuity Trust II
                    c/o Thomas J. Tisch
                    655 Madison Avenue
                    New York, NY  10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                  ____    Director
                  ____    Officer (give title below)
                  _X__    10% Owner
                  ____    Other (specify below)
                  ________________________

6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                   ____   Form filed by One Reporting Person
                   _X__   Form filed by More than One Reporting Person





                                       28
<PAGE>


             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  346,940

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D

4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)

     Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)

1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title




                                       29
<PAGE>


         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       30
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00



Joint Filer Information

1.   Name and Address of Reporting Person:

                    The Andrew H. Tisch 1999 Annuity Trust II
                    c/o Mr. Barry Bloom
                    655 Madison Avenue
                    New York, NY  10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                  ____    Director
                  ____    Officer (give title below)
                  _X__    10% Owner
                  ____    Other (specify below)


6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                   ____   Form filed by One Reporting Person
                   _X__   Form filed by More than One Reporting Person





                                       31
<PAGE>


             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  346,940

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D

4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)

     Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)

1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title




                                       32
<PAGE>


         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]





                                       33
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00


Joint Filer Information

1.   Name and Address of Reporting Person:

                    The Thomas J. Tisch 1999 Annuity Trust VI
                    c/o Mr. Barry Bloom
                    655 Madison Avenue
                    New York, NY  10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                  ____    Director
                  ____    Officer (give title below)
                  _X__    10% Owner
                  ____    Other (specify below)
                  ________________________


6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                   ____   Form filed by One Reporting Person
                   _X__   Form filed by More than One Reporting Person




                                       34
<PAGE>


             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  111,943

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D

4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)

     Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)

1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title




                                       35
<PAGE>


         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       36
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00



Joint Filer Information

1.   Name and Address of Reporting Person:

                    The Daniel R. Tisch 1999 Annuity Trust VI
                    c/o Mr. Barry Bloom
                    655 Madison Avenue
                    New York, NY  10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                  ____    Director
                  ____    Officer (give title below)
                  _X__    10% Owner
                  ____    Other (specify below)


6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                   ____   Form filed by One Reporting Person
                   _X__   Form filed by More than One Reporting Person





                                       37
<PAGE>


             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  111,943

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D

4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)

     Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)

1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title




                                       38
<PAGE>


         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       39
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00



Joint Filer Information

1.   Name and Address of Reporting Person:

                    The James S. Tisch 1999 Annuity Trust VI
                    c/o Mr. Barry Bloom
                    655 Madison Avenue
                    New York, NY  10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                  ____   Director
                  ____   Officer (give title below)
                  _X__   10% Owner
                  ____   Other (specify below)
                  _______________________

6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                   ____   Form filed by One Reporting Person
                   _X__   Form filed by More than One Reporting Person





                                       40
<PAGE>


             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  111,943

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D

4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)

     Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)

1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title




                                       41
<PAGE>


         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       42
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00



Joint Filer Information

1.   Name and Address of Reporting Person:

                    The Andrew H. Tisch 1999 Annuity Trust VI
                    c/o Mr. Barry Bloom
                    655 Madison Avenue
                    New York, NY  10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                  ____   Director
                  ____   Officer (give title below)
                  _X__   10% Owner
                  ____   Other (specify below)


6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                   ____   Form filed by One Reporting Person
                   _X__   Form filed by More than One Reporting Person





                                       43
<PAGE>


             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  111,943

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D

4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)

     Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)

1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title




                                       44
<PAGE>


         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       45
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00



Joint Filer Information

1.   Name and Address of Reporting Person:

                    The Thomas J. Tisch 2000 Annuity Trust IV
                    c/o Mr. Barry Bloom
                    655 Madison Avenue
                    New York, NY  10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                  ____   Director
                  ____   Officer (give title below)
                  _X__   10% Owner
                  ____   Other (specify below)
                  ______________________

6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                  ____   Form filed by One Reporting Person
                  _X__   Form filed by More than One Reporting Person





                                       46
<PAGE>


             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  88,242

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D

4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)

     Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)

1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title




                                       47
<PAGE>

         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       48
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00



Joint Filer Information

1.   Name and Address of Reporting Person:

                    The Daniel R. Tisch 2000 Annuity Trust IV
                    c/o Mr. Barry Bloom
                    655 Madison Avenue
                    New York, NY  10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                  ____   Director
                  ____   Officer (give title below)
                  __X_   10% Owner
                  ____   Other (specify below)
                  ____________________________

6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                   ____   Form filed by One Reporting Person
                   _X__   Form filed by More than One Reporting Person





                                       49
<PAGE>


             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  88,242

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D

4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)

     Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)

1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title




                                       50
<PAGE>


         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       51
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00



Joint Filer Information

1.   Name and Address of Reporting Person:

                    The James S. Tisch 2000 Annuity Trust IV
                    c/o Mr. Barry Bloom
                    655 Madison Avenue
                    New York, NY  10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                  ____   Director
                  ____   Officer (give title below)
                  _X__   10% Owner
                  ____   Other (specify below)
                  ________________________

6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                   ____   Form filed by One Reporting Person
                   _X__   Form filed by More than One Reporting Person





                                       52
<PAGE>


             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  88,242

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D

4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)

     Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)

1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title




                                       53
<PAGE>


         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       54
<PAGE>


                     Attachment To Form 3 of Thomas J. Tisch
                    in Respect of Neurogen Corporation (NRGN)
                   Date of Event Requiring Statement: 02/10/00



Joint Filer Information

1.   Name and Address of Reporting Person:

                    The Andrew H. Tisch 2000 Annuity Trust IV
                    c/o Mr. Barry Bloom
                    655 Madison Avenue
                    New York, NY  10021

2.   Date of Event Requiring Statement (Month/Day/Year)

                  02/10/00

3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary):



4. Issuer Name and Ticker or Trading Symbol:

                  Neurogen Corporation (NRGN)

5. Relationship of Reporting Person(s) to Issuer:

                  ____   Director
                  ____   Officer (give title below)
                  _X__   10% Owner
                  ____   Other (specify below)
                  _______________________

6.   If Amendment, Date of Original (Month/Day/Year)

                  03/16/99

7.   Individual or Joint/Group Filing (Check Applicable Line)

                  ____   Form filed by One Reporting Person
                  _X__   Form filed by More than One Reporting Person





                                       55
<PAGE>


             Table I - Non-Derivative Securities Beneficially Owned

1.   Title of Security

                  Common  Stock, $0.025 par value

2.   Amount of Securities Beneficially Owned

                  88,242

3.   Ownership Form:  Direct (D) or Indirect (I)

                  D

4.   Nature of Indirect Beneficial Ownership

                  (See explanation to Form 3 of Thomas J. Tisch)

     Table II - Derivative Securities Beneficially Owned (e.g., puts, calls,
                   warrants, options, convertible securities)

1.   Title of Derivative Security



2.   Date Exercisable and Expiration Date (Month/Day/Year)

         Date Exercisable



         Expiration Date



3.   Title and Amount of Securities Underlying Derivative Security

         Title




                                       56
<PAGE>

         Amount or Number of Shares



4.   Conversion or Exercise Price of Derivative Security



5.   Ownership Form of Derivative Security:  Direct (D) or Indirect (I)



6.   Nature of Indirect Beneficial Ownership

                  [Signatures follow all attachments]




                                       57
<PAGE>


                                    SIGNATURE


           WITNESS, the signatures of the undersigned this 23rd day of
February, 2000.

                                       FOUR-FOURTEEN PARTNERS, LLC

                                       By    /s/ Thomas J. Tisch
                                         ----------------------------------
                                                Thomas J. Tisch, Manager


                                      FOUR PARTNERS

                                      By    /s/ Thomas J. Tisch
                                         ----------------------------------
                                                Thomas J. Tisch, Manager


                                           /s/ Andrew H. Tisch
                                         ----------------------------------
                                               Andrew H. Tisch


                                          /s/ Daniel R. Tisch
                                         ----------------------------------
                                             Daniel R. Tisch


                                          /s/ James S. Tisch
                                         ----------------------------------
                                              James S. Tisch


                                          /s/ Thomas J. Tisch
                                         ----------------------------------
                                              Thomas J. Tisch


                                      THE ANDREW H. TISCH 1999 ANNUITY TRUST II


                                          By    /s/ Daniel R. Tisch
                                         ----------------------------------
                                            Daniel R. Tisch, Trustee





                                       58
<PAGE>


                                      THE DANIEL R. TISCH 1999 ANNUITY TRUST II

                                      By    /s/ James S. Tisch
                                         ----------------------------------
                                                James S. Tisch, Trustee


                                      THE JAMES S. TISCH 1999 ANNUITY TRUST II

                                      By    /s/ Thomas J. Tisch
                                         ----------------------------------
                                               Thomas J. Tisch, Trustee


                                      THE THOMAS J. TISCH 1999 ANNUITY TRUST II

                                      By    /s/ Andrew H. Tisch
                                         ----------------------------------
                                              Andrew H. Tisch, Trustee


                                      THE ANDREW H. TISCH 1999 ANNUITY TRUST VI

                                      By    /s/ Daniel R. Tisch
                                         ----------------------------------
                                                Daniel R. Tisch, Trustee


                                      THE DANIEL R. TISCH 1999 ANNUITY TRUST VI

                                      By    /s/ James S. Tisch
                                          ----------------------------------
                                                James S. Tisch, Trustee

                                      THE JAMES S. TISCH 1999 ANNUITY TRUST VI

                                      By     /s/ Thomas J. Tisch
                                         ----------------------------------
                                                Thomas J. Tisch, Trustee


                                      THE THOMAS J. TISCH 1999 ANNUITY TRUST VI

                                      By    /s/ Andrew H. Tisch
                                         ----------------------------------
                                                Andrew H. Tisch, Trustee


                                      THE ANDREW H. TISCH 2000 ANNUITY TRUST IV

                                      By    /s/ Daniel R. Tisch
                                         ----------------------------------
                                            Daniel R. Tisch, Trustee


                                      THE DANIEL R. TISCH 2000 ANNUITY TRUST IV

                                      By    /s/ James S. Tisch
                                         ----------------------------------
                                                James S. Tisch, Trustee




                                       59
<PAGE>


                                      THE JAMES S. TISCH 2000 ANNUITY TRUST IV

                                      By    /s/ Thomas J. Tisch
                                         ----------------------------------
                                                Thomas J. Tisch, Trustee


                                      THE THOMAS J. TISCH 2000 ANNUITY TRUST IV

                                      By    /s/ Andrew H. Tisch
                                         ----------------------------------
                                                Andrew H. Tisch, Trustee






                                       60


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