NEUROGEN CORP
10-Q, 2000-08-14
PHARMACEUTICAL PREPARATIONS
Previous: ALLIED WASTE INDUSTRIES INC, 10-Q, EX-27, 2000-08-14
Next: NEUROGEN CORP, 10-Q, EX-27, 2000-08-14









                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 10-Q

              [X] QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d)
                     OF THE SECURITIES EXCHANGE ACT OF 1934
                  For the quarterly period ended June 30, 2000
                                       OR
              [ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                         Commission File Number 0-18311


                              NEUROGEN CORPORATION
             (Exact name of registrant as specified in its charter)


              Delaware                               22-2845714
   (State or other jurisdiction of                (I.R.S. Employer
   incorporation or organization)                 Identification No.)


                          35 Northeast Industrial Road
                           Branford, Connecticut 06405
               (Address of principal executive offices) (Zip Code)


                                 (203) 488-8201
              (Registrant's telephone number, including area code)



     Indicate  by check mark  whether the  registrant  (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days.

                                    Yes X        No
                                       ---         ---



     As of August 14, 2000 the registrant had 17,265,616  shares of Common Stock
outstanding.




<PAGE>




                              NEUROGEN CORPORATION

                                      INDEX


                                                                           Page
                                                                          Number

                         Part I - Financial Information


Item 1. Consolidated Financial Statements..................................  1

        Consolidated Balance Sheets at June 30, 2000 and
         December 31, 1999................................................. 1,2
        Consolidated Statements of Operations for the three-month and
         six-month periods ended June 30, 2000 and 1999 ...................  3
        Consolidated Statements of Cash Flows for the six-month periods
         ended June 30, 2000 and 1999 .....................................  4
        Notes to Consolidated Financial Statements......................... 5,6

Item 2. Management's Discussion and Analysis of Financial Condition and
         Results of Operations............................................. 7-11

Item 3. Quantitative and Qualitative Disclosures About Market Risk.........  11

                           Part II - Other Information

Item 1. Legal Proceedings.................................................   12

Item 2. Changes in Securities and Use of Proceeds.........................   12

Item 3. Defaults upon Senior Securities...................................   12

Item 4. Submission of Matters to a Vote of Security Holders...............   12

Item 5. Other Information.................................................   13

Item 6. Exhibits and Reports on Form 8-K..................................   13

Signature  ................................... ...........................   15

Exhibit Index  ........................................................... 16-18




<PAGE>


                         PART I - FINANCIAL INFORMATION

ITEM 1 - CONSOLIDATED FINANCIAL STATEMENTS

<TABLE>
<CAPTION>


                                                    NEUROGEN CORPORATION
                                                 CONSOLIDATED BALANCE SHEETS
                                                       (In thousands)



                                                           JUNE 30, 2000                 DECEMBER 31, 1999
                                                            (UNAUDITED)                       (AUDITED)
<S>                                                        --------------                -----------------
                                                                <C>                             <C>
                     Assets

Current assets:
   Cash and cash equivalents                               $     102,644                   $       31,588
   Marketable securities                                          13,800                           33,441
   Receivables from corporate partners                             1,568                              286
   Other current assets                                              676                              921
                                                            -------------                  ---------------
       Total current assets                                      118,688                           66,236

Property, plant & equipment:
   Land and land improvements                                         875                              875
   Building and building improvements                              16,825                           16,834
   Construction in progress                                         2,061                            1,702
   Leasehold improvements                                           4,026                            4,026
   Equipment                                                       12,257                           11,440
   Furniture                                                          588                              578
                                                           ---------------                 ----------------
                                                                   36,632                           35,455
   Less accumulated depreciation & amortization                    11,063                            9,840
                                                           ---------------                 ----------------
       Net property, plant and equipment                           25,569                           25,615

Other assets, net                                                     312                              283
                                                           ---------------                 ----------------
                                                           $      144,569                  $        92,134
                                                           ===============                 ================

</TABLE>





See accompanying notes to consolidated financial statements.






                                       1
<PAGE>



<TABLE>
<CAPTION>


                                                    NEUROGEN CORPORATION
                                                 CONSOLIDATED BALANCE SHEETS
                                            (In thousands, except per share data)



                                                             JUNE 30, 2000              DECEMBER 31, 1999
                                                               (UNAUDITED)                   (AUDITED)
                                                           -----------------             -----------------
<S>                                                                <C>                          <C>
            Liabilities & Stockholders' Equity

Current liabilities:
   Accounts payable and accrued expenses                   $          5,020              $           2,704
   Unearned revenue from corporate partners, current portion          9,393                          1,260
                                                             -----------------             ------------------
       Total current liabilities                                     14,413                          3,964

Loans payable                                                         1,912                          1,912
Unearned revenue from corporate partners, long term portion           6,250                          1,500
Other compensation                                                       23                             48
                                                             -----------------             ------------------
       Total liabilities                                             22,598                          7,424

Commitments and Contingencies
Stockholders' Equity:
   Preferred stock, par value $.025 per share
       Authorized 2,000 shares; none issued                              -                              -
   Common stock, par value $.025 per share
       Authorized 30,000 shares;  issued and outstanding
       17,254 shares at June 30, 2000 and 14,800 shares
       at December 31, 1999                                             431                            370
   Subscription receivable                                           (3,750)                            -
   Additional paid-in capital                                       167,125                        114,519
   Accumulated deficit                                              (40,169)                       (26,852)
   Deferred compensation                                             (1,457)                        (3,076)
   Accumulated other comprehensive income                              (209)                          (251)
                                                           -----------------             ------------------
       Total stockholders' equity                                   121,971                         84,710
                                                           -----------------             ------------------
                                                           $        144,569              $          92,134
                                                           =================             ==================



</TABLE>



See accompanying notes to consolidated financial statements.





                                       2
<PAGE>

<TABLE>
<CAPTION>

                                                            NEUROGEN CORPORATION
                                                    CONSOLIDATED STATEMENTS OF OPERATIONS
                                                   (In thousands, except per share data)



                                                               THREE MONTHS       THREE MONTHS       SIX MONTHS      SIX MONTHS
                                                                   ENDED              ENDED            ENDED            ENDED
                                                               JUNE 30, 2000      JUNE 30, 1999     JUNE 30, 2000   JUNE 30, 1999
                                                                (UNAUDITED)        (UNAUDITED)       (UNAUDITED)     (UNAUDITED)
                                                             ----------------    ---------------   --------------   -------------
<S>                                                                 <C>                 <C>              <C>             <C>

Operating revenues:
   License fees                                              $         2,117       $          -      $     2,367     $        -
   Research and development                                            2,398              2,343            4,989           4,980
                                                             ----------------    ---------------    -------------   -------------
       Total operating revenues                                        4,515              2,343            7,356           4,980
Operating expenses:
   Research and development                                            6,641              5,893           13,080          11,727
   General and administrative                                          1,525              1,022            2,929           2,121
   Stock Compensation                                                     75                 29            6,671              51
                                                             ----------------    ----------------   -------------   -------------
       Total operating expenses                                        8,241              6,944           22,680          13,899
                                                             ----------------    ----------------   -------------   -------------
            Operating loss                                            (3,726)            (4,601)         (15,324)         (8,919)
Other income (expense):
   Investment income                                                   1,079                887            2,008           1,800
   Interest expense                                                                          (1)                              (2)
                                                             ----------------    ----------------   -------------   -------------
       Total other income, net                                         1,709                886            2,008           1,798
                                                             ----------------    ----------------   -------------   -------------
Loss before provision for income taxes                                (2,647)            (3,715)         (13,316)         (7,121)
Provision for income taxes                                                -                  -                -               -
                                                             ----------------    ----------------   -------------   -------------
Net loss                                                     $        (2,647)    $       (3,715)    $    (13,316)   $     (7,121)
                                                             ================    ================   =============   =============
Net loss per share:
   Basic                                                     $         (0.17)(1) $        (0.26)(1) $     (0.86)(1) $     (0.49)(1)
                                                             ================    ================   =============   =============
   Diluted                                                   $         (0.17)(1) $        (0.26)(1)$      (0.86)(1)$      (0.49)(1)
                                                             ================    ================   =============   =============
Shares used in calculation of loss per share:
   Basic                                                              15,592 (1)         14,554 (1)       15,512(1)       14,551(1)
                                                             ================    ================   =============   =============
   Diluted                                                            15,592 (1)         14,554 (1)       15,512(1)       14,551(1)
                                                             ================    ================   =============   =============

</TABLE>


See accompanying notes to consolidated financial statements.

(1) The contingently issuable common stock securities have not been  included in
    accordance with FAS128.

                                       3
<PAGE>


<TABLE>
<CAPTION>

                                                             NEUROGEN CORPORATION
                                                      CONSOLIDATED STATEMENTS OF CASH FLOWS
                                                                (In thousands)


                                                                         SIX MONTHS           SIX MONTHS
                                                                            ENDED                ENDED
                                                                        JUNE 30, 2000        JUNE 30, 1999
                                                                        (UNAUDITED)           (UNAUDITED)
                                                                    -----------------      ---------------
<S>                                                                          <C>                   <C>


Cash flows from operating activities:
   Net loss                                                         $      (13,316)         $      (7,121)
   Adjustments to reconcile net loss to net cash provided by
     (used in) operating activities:
       Depreciation and amortization expense                                 1,075                  1,260
       Stock compensation expense                                            6,671                     51
       Other noncash compensation                                              287                    256
       Loss on disposal of assets                                               34                     -
   Changes in operating assets and liabilities:
       Increase (decrease) in accounts payable and accrued expenses             37                   (946)
       Increase  in unearned revenue from corporate partners                12,883                  3,000
       (Increase)decrease in receivable from corporate partners             (1,282)                   455
       Decrease in other assets, net                                           153                    203
                                                                     -----------------      ---------------
          Net cash provided by (used in) operating activities                6,542                 (2,842)

Cash flows from investing activities:
       Purchase of plant and equipment                                        (991)                  (605)
       Purchases of marketable securities                                   (1,578)               (11,858)
       Maturities and sales of marketable securities                        21,261                 36,316
                                                                     -----------------      ---------------
          Net cash provided by investing activities                         18,692                 23,853

Cash flows from financing activities:
       Exercise of employee stock options                                    8,622                    284
       Proceeds from private placement of common stock                      37,200                     -
       Principal payments under mortgage payable                                -                     (74)
                                                                     -----------------      ---------------
          Net cash provided by financing activities                         45,822                    210
                                                                     -----------------      ---------------
Net increase in cash and cash equivalents                                   71,056                 21,221
Cash and cash equivalents at beginning of period                            31,588                 26,066
                                                                     -----------------      ---------------
Cash and cash equivalents at end of period                           $     102,644          $      47,287
                                                                     =================      ===============

</TABLE>


See accompanying notes to consolidated financial statements.



                                       4
<PAGE>
                              Neurogen Corporation
                   Notes to Consolidated Financial Statements
                                  June 30, 2000
                                   (Unaudited)

 (1)      BASIS OF PRESENTATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

               The unaudited  financial  statements  have been prepared from the
          books  and  records  of  Neurogen   Corporation   (the  "Company")  in
          accordance with generally accepted  accounting  principles for interim
          financial  information  pursuant  to Rule  10-01  of  Regulation  S-X.
          Accordingly,  they do not include all of the information and footnotes
          required by  generally  accepted  accounting  principles  for complete
          financial  statements.  In the opinion of management,  all adjustments
          (consisting of normal recurring accruals)  considered  necessary for a
          fair  presentation   have  been  included.   These  interim  financial
          statements  should be read in conjunction  with the audited  financial
          statements  for the year  ended  December  31,  1999  included  in the
          Company's  Annual  Report  on  Form  10-K.  Interim  results  are  not
          necessarily  indicative  of the results  that may be expected  for the
          fiscal year.

 (2)      REVENUE RECOGNITION

               Revenue under research and development arrangements is recognized
          as  earned  under  the  terms of the  respective  agreements.  License
          payments under separate license  agreements are recorded when received
          and the  license  agreements  are signed  and there are no  continuing
          obligations  on the part of the  Company.  When  further  efforts  are
          required,  the license  fees are  recognized  over the  related  term.
          Product  research  funding is  recorded  as  revenue,  generally  on a
          quarterly  basis,  as research  effort is incurred.  Deferred  revenue
          arises from  payments  received  which have not yet been earned  under
          research and development as well as in arrangements in contracts where
          both research and  development and licensing are included and Neurogen
          has some level of continued involvement.

               In  December  1999,  the  staff of the  Securities  and  Exchange
          Commission  issued its Staff  Accounting  Bulletin  ("SAB")  No.  101,
          REVENUE RECOGNITION. SAB No. 101, as amended by SAB No. 101A and 101B,
          provides guidance on the measurement and timing of revenue recognition
          in financial  statements  of public  companies.  Changes in accounting
          policies  to apply the  guidance  of SAB No.  101 must be  adopted  by
          recording the  cumulative  effect of the change in the fiscal  quarter
          ending December 31, 2000.

               SAB No. 101  requires  that  license and other up front fees from
          research  collaborations  be recognized over the term of the agreement
          unless the fee is in  exchange  for  products  delivered  or  services
          performed  that  represent  the  culmination  of a  separate  earnings
          process.  The Company believes its current revenue  recognition policy
          is in compliance  with SAB No. 101 and the application of the guidance
          to their  financial  statements  will not result in a material  change
          upon adoption in the fourth quarter of 2000.

 (3)      PRINCIPLES OF CONSOLIDATION

               The consolidated financial statements include the accounts of the
          parent  company  and a  subsidiary,  Neurogen  Properties  LLC,  after
          elimination of intercompany transactions.

 (4)      SEGMENT  INFORMATION

               In 1998, the Company  adopted  Statement of Financial  Accounting
          Standards No. 131,  Disclosures  about  Segments of an Enterprise  and
          Related  Information  (SFAS No. 131). SFAS No. 131 supersedes SFAS No.
          14,  Financial  Reporting  for  Segments  of  a  Business  Enterprise,
          replacing  the  "industry  segment"  approach  with  the  "management"
          approach. The management approach designates the internal organization
          that  is  used  by  management  for  making  operating  decisions  and
          assessing  performance  as  the  source  of the  Company's  reportable
          segments.  The Company  operates in one segment:  drug  discovery  and
          pharmaceutical  development.  SFAS No. 131 also  requires  disclosures
          about products and services, geographic area, and major customers. The
          adoption  of SFAS No.  131 had no  impact on the  Company's  financial
          statements for the periods presented.

 (5)      RECLASSIFICATIONS

               Certain  reclassifications  have been made to the 1999  financial
          statements in order to conform to the 2000 presentation.

                                       5

<PAGE>


 (6)      NON-CASH COMPENSATION CHARGE

               At December 31,1999, 137,625 shares of restricted stock were held
          by certain employees.  The original December 31, 1998 grant stipulated
          that if the stock  price  closed at or above  $45.00 per share  within
          four years from date of grant the restriction would be removed and the
          employee would be able to trade the stock,  but if the stock price did
          not close at or above  $45.00  within  four years the shares  would be
          forfeited.

               On February  18, 2000,  Neurogen  stock closed the trading day at
          $47.25,  thereby  removing  the  restriction  and  vesting  the  stock
          immediately. A non-recurring,  non-cash charge to income of $6,503,000
          for all 137,625  shares at $47.25 per share was  recorded in the first
          quarter of 2000.

 (7)      PRIVATE PLACEMENT

               On June 30, 2000,  the Company  entered into a private  placement
          agreement with certain institutional investors,  pursuant to which the
          Company  issued  1,638,000  shares of its  common  stock at $25.00 per
          share for gross  proceeds  of  $40,950,00,  of which  $37,200,000  was
          received by June 30th.  The Company  also  incurred  cash  expenses of
          approximately  $2,500,000  in connection  with the private  placement,
          which will result in total net proceeds of $38,450,000.






                                       6
<PAGE>
Item 2.   MANAGEMENT'S DISCUSSION AND ANALYSIS OF
          FINANCIAL CONDITION AND RESULTS OF OPERATIONS

               Since its inception in September 1987,  Neurogen has been engaged
          in the discovery and development of drugs. The Company has not derived
          any revenue from product sales and expects to incur significant losses
          in most years prior to deriving any such product revenues. Revenues to
          date have come from three  collaborative  research  agreements and one
          technology   transfer   agreement   entered  into  with  Pfizer,   one
          collaboration  with   Schering-Plough,   one  license  agreement  with
          American Home Products and from interest income.

          RESULTS OF OPERATIONS

               Results of operations may vary from period to period depending on
          numerous factors, including the timing of income earned under existing
          or future strategic alliances,  technology transfer agreements,  joint
          ventures or financings, if any, the progress of the Company's research
          and  development  and  technology  transfer  projects,   technological
          advances and determinations as to the commercial potential of proposed
          products.  Neurogen expects research and development costs to increase
          significantly  over the  next  several  years as its drug  development
          programs progress.  In addition,  general and administrative  expenses
          necessary to support the expanded research and development  activities
          are expected to increase for the foreseeable future.

          THREE MONTHS ENDED JUNE 30, 2000 AND 1999

               The Company's  operating  revenues  increased to $4.5 million for
          the three  months  ended June 30, 2000 as compared to $2.3 million for
          the same period in 1999.  This increase in operating  revenues was due
          to the  recognition  of $2.2 million in revenue  recognized  under the
          Pfizer Technology  Transfer  Agreement  (described  below).  Operating
          revenues in future  periods may  fluctuate  significantly  due to many
          factors, including those described throughout this section.

               Research and  development  expenses  increased 13 percent to $6.6
          million for the three-month  period ended June 30, 2000 as compared to
          $5.9  million for the same period in 1999.  The  increase is primarily
          due to increases in research and development  personnel as well as the
          Company's  further  expansion of its AIDD Program for the discovery of
          new drug candidates.  Research and development expenses represented 81
          percent and 85 percent of total  expenses  in the three month  periods
          ended June 30, 2000 and 1999, respectively.

               General and administrative  expenses increased 49 percent to $1.5
          million for the three-month  period ended June 30, 2000 as compared to
          $1.0 million for the same period in 1999.  This increase is attributed
          to additional  administrative and technical services, and personnel to
          support the  protection of Neurogen's  growing  intellectual  property
          estate and the pursuit of  potential  collaborative  relationships  to
          support and commercialize Neurogen's expanding research pipeline.

               Other income,  consisting  primarily of interest income and gains
          and losses from invested cash and marketable securities,  increased 22
          percent for the second  quarter of 2000 as compared to the same period
          in 1999 due primarily to higher available interest rates.

               The Company  recognized  a net loss of $2.6 million for the three
          months ended June 30, 2000 as compared with a net loss of $3.7 million
          for the same period in 1999. The decrease in the net loss is primarily
          due to the  recognition  of $2.2  million in revenue  under the Pfizer
          Technology Transfer Agreement in the second quarter of 2000, offset by
          increases in general and  administrative  and research and development
          expenses due to the factors described above.


                                       7
<PAGE>



          SIX MONTHS ENDED JUNE 30, 2000 AND 1999

               The Company's  operating  revenues  increased to $7.4 million for
          the six months  ended  June 30,  2000 from $5.0  million  for the same
          period in 1999.  The  increase in  operating  revenues  was due to the
          recognition  of $2.4  million in revenue  under the Pfizer  Technology
          Transfer  Agreement  (described  below).  Operating revenues in future
          periods may fluctuate  significantly  due to many  factors,  including
          those described throughout this section.

               Research and development  expenses  increased 12 percent to $13.1
          million  for the six months  ended June 30,  2000 as compared to $11.8
          million for the same period in 1999. This increase is primarily due to
          increases  in  research  and  development  personnel  as  well  as the
          Company's  further  expansion of its AIDD Program for the discovery of
          new drug candidates.  Research and development expenses represented 81
          percent  of  total  operating  expenses  (excluding  a  non-recurring,
          non-cash  compensation charge) for the six-month period ended June 30,
          2000 as compared to 84 percent for the same period in 1999.

               General and administrative  expenses increased 38 percent to $2.9
          million for the  six-month  period  ended June 30, 2000 as compared to
          $2.1 million for the same period in 1999.  This increase is attributed
          to additional  administrative and technical services, and personnel to
          support the  protection of Neurogen's  growing  intellectual  property
          estate and the pursuit of  potential  collaborative  relationships  to
          support and commercialize Neurogen's expanding research pipeline.

               Other income,  consisting  primarily of interest income and gains
          and losses from invested cash and marketable securities,  increased to
          $2.0  million  for the six months  ended June 30,  2000 as compared to
          $1.8  million for the same  period in 1999,  due  primarily  to higher
          available interest rates.

               The Company  recognized  a net loss of $13.3  million for the six
          months ended June 30, 2000 as compared with a net loss of $7.1 million
          for the same period in 1999. The increase in net loss is primarily due
          to a  non-recurring  non-cash  $6.5 million  charge  recognized in the
          first quarter of 2000 upon the vesting of 137,625 shares of restricted
          stock granted to certain employees in 1998.

                LIQUIDITY AND CAPITAL RESOURCES

               At June 30, 2000 and December 31, 1999,  cash,  cash  equivalents
          and  marketable  securities  were in the aggregate  $116.4 million and
          $65.0  million  respectively.  This  increase was due primarily to the
          receipt  in the  first  half of 2000 of $37.2  million  from a private
          placement of common stock, $8.7 million in stock option exercises, and
          the  receipt  of $14.0  million  in  payments  from  Pfizer  under the
          Technology  Transfer  Agreement  described below.  While the Company's
          aggregate  level of cash, cash  equivalents and marketable  securities
          increased  during the first half of 2000, these levels have fluctuated
          significantly in the past and are expected to do so in the future as a
          result of the factors described below.

               Neurogen's  cash  requirements  to  date  have  been  met  by the
          proceeds of its financing  activities,  amounts  received  pursuant to
          collaborative or technology transfer  arrangements and interest earned
          on invested funds. The Company's financing  activities include private
          placement  offerings of its common  stock,  three prior to its initial
          public offering and one subsequent,  underwritten  public offerings of
          the  Company's  common stock in 1989,  1991 and 1995,  and the private
          sale of common stock to Pfizer in  connection  with  entering into the
          Pfizer  Agreements  and  to  American  Home  Products  in a  licensing
          agreement.  Total funding received from these financing activities was
          approximately $142.8 million. The Company's  expenditures to date have
          been  primarily  to fund  research  and  development  and  general and
          administrative  expenses and to  construct  and equip its research and
          development facilities.


                                        8










<PAGE>

               In the first quarter of 1992,  the Company  entered into the 1992
          Pfizer Agreement  pursuant to which Pfizer made a $13.8 million equity
          investment in the Company and agreed,  among other  things,  to fund a
          specified  level of resources for up to five years (later  extended as
          described below) for Neurogen's research programs for the discovery of
          GABA-based drugs for the treatment of anxiety and cognitive disorders.
          As of June 30,  2000,  Pfizer had provided  $38.7  million of research
          funding to the  Company  pursuant  to the 1992  Pfizer  Agreement,  as
          extended,  and $0.5 million for the  achievement  of certain  clinical
          development and regulatory milestones. Neurogen is eligible to receive
          additional  milestone  payments  of up to  $12.0  million  if  certain
          development  and  regulatory  objectives  are achieved  regarding  its
          products subject to the collaboration.  In return, Pfizer received the
          exclusive rights to manufacture and market  collaboration  anxiolytics
          and cognition enhancers that act through the family of receptors which
          interact  with the  neuro-transmitter  GABA.  Pfizer will pay Neurogen
          royalties based upon net sales levels, if any, for such products.

               Neurogen  and  Pfizer  entered  into their  second  collaborative
          agreement,  the 1994 Pfizer Agreement, in July 1994, pursuant to which
          Pfizer  made an  additional  $9.9  million  equity  investment  in the
          Company and agreed,  among other things,  to fund a specified level of
          resources for up to four years (later extended as described below) for
          Neurogen's  research  program for the development of GABA-based  drugs
          for the treatment of sleep disorders.  As of June 30, 2000, Pfizer had
          provided $12.6 million of research  funding to the Company pursuant to
          the 1994  Pfizer  Agreement,  as  extended,  and $0.3  million for the
          achievement of a clinical development  milestone.  Neurogen could also
          receive additional milestone payments of up to $3.0 million if certain
          development  and  regulatory  objectives  are achieved  regarding  its
          products subject to the collaboration.  In return, Pfizer received the
          exclusive  rights to manufacture and market  GABA-based sleep disorder
          products for which it will pay Neurogen royalties based upon net sales
          levels, if any.

               In December 1996 and again in December 1998,  Neurogen and Pfizer
          extended and combined  Neurogen's  research efforts under the 1992 and
          1994 Agreements.  Pursuant to the extension  agreements,  Neurogen has
          received $3.1 million in the first six months of 2000 (which amount is
          included in the  above-described  cumulative  totals  received for the
          1992 and 1994  agreements) and under the extension  expects to receive
          an additional  $3.1 million  during the remainder of 2000 for research
          and  development  funding  of  the  Company's  GABA-based  anxiolytic,
          cognitive enhancer and sleep disorders projects.

               Under  both  the  1992  Pfizer  Agreement  and  the  1994  Pfizer
          Agreement,  in  addition  to making  the  equity  investments  and the
          research and milestone payments noted above, Pfizer is responsible for
          funding the cost of all clinical development and the manufacturing and
          marketing,  if  any,  of  drugs  developed  from  the  collaborations.



                                       9
<PAGE>
               Neurogen  and  Pfizer  entered  into  their  third  collaborative
          agreement,  the 1995 Pfizer Agreement,  in November 1995,  pursuant to
          which Pfizer made an additional $16.5 million equity investment in the
          Company bringing  Pfizer's  ownership of the Company's common stock up
          to approximately  21 percent.  Pfizer also paid a $3.5 million license
          fee.  Additionally  Pfizer  agreed,  among  other  things,  to  fund a
          specified  level of  resources  for up to five  years  for  Neurogen's
          research  program for the  discovery  of drugs which work  through the
          neuropeptide Y (NPY)  mechanism for the treatment of obesity and other
          disorders.  As of June 30, 2000,  Pfizer had provided $13.0 million in
          research  funding  pursuant  to the 1995  Pfizer  Agreement.  In 1998,
          Pfizer  exercised its option under the 1995 Pfizer Agreement to extend
          the NPY research  program and also agreed to fund  increased  Neurogen
          staffing on the program and thereby pay Neurogen  $3.1 million to fund
          a fourth year of  research,  through  October  1999.  In 1999,  Pfizer
          elected to further extend the research  program  through  October 2000
          and to pay Neurogen  $2.6  million in 2000 for  research  done through
          that date.  Neurogen  could also receive  milestone  payments of up to
          approximately  $28.0  million if certain  development  and  regulatory
          objectives  are  achieved   regarding  its  products  subject  to  the
          collaboration.  As part of this third  collaboration,  Pfizer received
          the exclusive  worldwide  rights to manufacture  and market  NPY-based
          collaboration  compounds,   subject  to  certain  rights  retained  by
          Neurogen. Pursuant to the 1995 Pfizer Agreement,  Neurogen will fund a
          minority  share of early  stage  clinical  development  costs  and has
          retained the right to manufacture any collaboration  products in NAFTA
          countries.  Neurogen has also  retained a profit  sharing  option with
          respect to product sales in NAFTA countries. If Neurogen exercises the
          profit  sharing  option,  it will fund a  portion  of the cost of late
          stage  clinical  trials and  marketing  costs and in return  receive a
          specified percentage of any profit generated by sales of collaboration
          products in NAFTA  countries.  If Neurogen chooses not to exercise its
          profit-sharing  option,  Pfizer would pay Neurogen  royalties on drugs
          marketed  in NAFTA  countries  and will fund a majority of early stage
          and all late stage development and marketing expenses.  In either case
          Neurogen would be entitled to royalties on drugs marketed in non-NAFTA
          countries.

               In June 1999,  Neurogen  and  Pfizer  entered  into a  technology
          transfer  agreement,  (the "Pfizer  Technology  Transfer  Agreement").
          Under the terms of this agreement, Pfizer has agreed to pay Neurogen a
          total of $27.0  million over a three year period for the licensing and
          transfer to Pfizer of certain of Neurogen's AIDD  technologies for the
          discovery of new drugs, along with the installation of an AIDD system.
          Additional   payments  are  also  possible  upon  Pfizer's  successful
          utilization of this  technology.  Pfizer has received a  non-exclusive
          license to certain AIDD intellectual property, and the right to employ
          this technology in its own drug development  programs.  As of June 30,
          2000,  Pfizer had provided  $17.0  million in license fees pursuant to
          the Pfizer AIDD agreement of which $2.9 million has been recognized to
          date.  Remaining  revenues  associated with amounts received under the
          Pfizer  Technology  Transfer  Agreement  will be  recognized in future
          periods and may  fluctuate  significantly  depending on the timing and
          completion  of  the  Company's  transfer  of  technology  and  systems
          pursuant to the agreement.

               The  Company  plans  to  use  its  cash,  cash   equivalents  and
          marketable  securities  for its research and  development  activities,
          working capital and general corporate purposes.  Neurogen  anticipates
          that its current cash balance,  as  supplemented  by research  funding
          pursuant to the Pfizer Agreements and fees it expects to receive under
          the Pfizer Technology Transfer  Agreement,  will be sufficient to fund
          its current and planned operations through 2002.  However,  Neurogen's
          funding requirements may change and will depend upon numerous factors,
          including but not limited to, the progress of the  Company's  research
          and  development  programs,  the  timing and  results  of  preclinical
          testing and  clinical  studies,  the timing of  regulatory  approvals,
          technological advances,  determinations as to the commercial potential
          of its proposed products,  the status of competitive  products and the
          ability  of  the  Company  to  establish  and  maintain  collaborative
          arrangements  with others for the purpose of funding certain  research
          and  development  programs,  conducting  clinical  studies,  obtaining
          regulatory   approvals   and,   if  such   approvals   are   obtained,
          manufacturing and marketing products.  The Company anticipates that it
          may augment its cash balance through financing transactions, including
          the  issuance  of debt or  equity  securities  and  further  corporate
          alliances.  No  assurances  can  be  given  that  adequate  levels  of
          additional funding can be obtained on favorable terms, if at all.



                                       10







<PAGE>
              As of December  31,  1999,  the Company had  approximately  $37.1
          million  and $2.8  million of net  operating  loss  carryforwards  and
          research and development credits, respectively,  available for federal
          income tax purposes  which expire in the years 2004 through 2019.  The
          Company  also had  approximately  $25.6  million  and $0.7  million of
          Connecticut  state tax net operating loss  carryforwards  and research
          and development credits, respectively,  which expire in the years 2000
          through 2014.  Because of "change in ownership"  provisions of the Tax
          Reform Act of 1986,  our  utilization  of our net  operating  loss and
          research and  development  credit  carryforwards  may be subject to an
          annual limitation in future periods.

          DISCUSSION OF THE YEAR 2000 ISSUE

              Neurogen's  program to address the Year 2000 issue  consisted  of
          assessment,   remediation,   testing  and  contingency  planning.  The
          Company's   program  was  initiated  and  executed  to  prevent  major
          interruptions  in  the  business  due to  Year  2000  problems.  As of
          December  31,  1999,  all phases were  completed.  The Company did not
          experience  any  significant  disruption  as a result of the Year 2000
          issue.  The total  cost of the Year  2000  program  was  approximately
          $200,000,  primarily for the cost of replacing/upgrading  noncompliant
          software.

               The Company  completed its  assessment of Year 2000 risks related
          to significant  relationships  with critical third party suppliers and
          customers.  Despite these efforts,  there can be no assurance that all
          supplier and customer  Year 2000  compliance  plans were  successfully
          completed in a timely  manner,  although the Company is not  currently
          aware of any problems which would significantly impact operations.

          Item 3.  QUANTITATIVE  AND QUALITATIVE  DISCLOSURES  ABOUT MARKET RISK

               Interest rate risk. The Company's  investment  portfolio includes
          investment  grade debt  instruments.  These  securities are subject to
          interest  rate  risk,  and could  decline in value if  interest  rates
          fluctuate.  Due to the short duration and conservative nature of these
          instruments,  the  Company  does not  believe  that it has a  material
          exposure to interest rate risk.  Additionally,  funds  available  from
          investment  activities are dependent upon available  investment rates.
          These  funds may be higher or lower than  anticipated  due to interest
          rate volatility.

               Capital  market  risk.  The  Company  currently  has  no  product
          revenues and is dependent on funds raised through other  sources.  One
          source of funding is through further equity offerings.  The ability of
          the Company to raise funds in this manner is  dependent  upon  capital
          market forces affecting the stock price of the Company.




                                       11


<PAGE>
                           Part II - Other Information

Item 1. Legal Proceedings

              Not applicable for the second quarter ended June 30, 2000.

Item 2. Changes in Securities

               On June 28, 2000, the Company  entered into  definitive  purchase
          agreements  with  selected  institutional  investors  for the  sale of
          newly-issued  common stock in the  aggregate of 1,638,000  shares at a
          price of  $25.00  per  share,  resulting  in total  cash  proceeds  of
          $40,950,000.  The  net  proceeds  will be  utilized  in  applying  the
          Company's AIDD  technologies  to new drug discovery  targets  emerging
          from the sequencing of the human genome.

               The  shares  of  common  stock  sold  in the  offering  were  not
          registered  pursuant to the exemptions in section 4(2) of Regulation D
          under the Securities Act of 1993 as amended,  and could not be offered
          or  sold  absent   registration   or  an  applicable   exemption  from
          registration.  The Company filed a registration  statement on July 14,
          2000, to register the shares for resale.

Item 3. Defaults upon Senior Securities

              Not applicable for the second quarter ended June 30, 2000.

Item 4. Submission of Matters to a Vote of Security Holders

               On June  19,  2000,  the  Company  held  its  annual  meeting  of
          stockholders  (i) to  elect  a board  of  twelve  directors  (Proposal
          1);(ii)to adopt the Neurogen  Corporation 2000 Non-Employee  Directors
          Stock Option Program  (Proposal 2) and (iii) to ratify the appointment
          by  the  Board  of  Directors  of  PricewaterhouseCoopers  LLP  as the
          independent  auditors  for the  Company  for the  fiscal  year  ending
          December 31, 2000 (Proposal 3).

          Proposal 1

               The  stockholders  elected the persons named below, the Company's
          nominees for directors, as directors of the Company,  casting votes in
          favor of such nominees or withholding votes as indicated:
<TABLE>
<CAPTION>
<S>                            <C>                      <C>
                              Votes in Favor           Votes Withheld
                              --------------           --------------

Felix J. Baker, Ph.D.          11,522,406                  10,128
Julian C. Baker                11,522,406                  10,128
Barry M. Bloom, Ph.D.          11,522,406                  10,128
Robert N. Butler               11,522,406                  10,128
Frank C. Carlucci              11,522,506                  10,028
Jeffrey J. Collinson           11,522,606                   9,928
Mark Novitch, M.D.             11,522,606                   9,928
Harry H. Penner, Jr.           11,522,606                   9,928
Robert H. Roth, Ph.D.          11,522,606                   9,928
John Simon                     11,522,606                   9,928
John F. Tallman, Ph.D.         11,522,606                   9,928
Suzanne H. Woolsey, Ph.D.      11,522,606                   9,928

 </TABLE>
          All of the Directors  elected are  continuing  their term of office as
          Directors after the annual meeting.

          The Stockholders approved Proposal 2, voting as follows:



                    Affirmative Votes       Negative Votes       Votes Abstained
                    -----------------       --------------       ---------------
Proposal 2             10,885,742              640,267                6,525

               The Stockholders approved Proposal 3, voting as follows:

                    Affirmative Votes       Negative Votes       Votes Abstained
                    -----------------       --------------       ---------------
Proposal 3             11,526,951                2,303                3,280



                                     12
<PAGE>

Item 5. Other Information

               Not applicable for the second quarter ended June 30, 2000.

Item 6. Exhibits and Reports on Form 8-K

               (a) See Exhibit Index on page 16.

               (b) The  Company  filed a Current  Report on Form 8-K on July 12,
                   2000 to  submit  for  filing a News  Release  of the  Company
                   dated June 29, 2000 disclosing definitive purchase agreements
                   for the sale of  newly-issued  common  stock  by the  Company
                   to  selected institutional investors on June 28, 2000.

                                     13
<PAGE>



          SAFE HARBOR STATEMENT

               Statements which are not historical facts,  including  statements
          about the Company's  confidence and strategies,  the status of various
          product development programs,  the sufficiency of cash to fund planned
          operations and the Company's  expectations  concerning its development
          compounds,  drug  discovery  technologies  and  opportunities  in  the
          pharmaceutical marketplace are "forward looking statements" within the
          meaning of the Private Securities  Litigations Reform Act of 1995 that
          involve  risks  and  uncertainties  and are not  guarantees  of future
          performance. These risks include, but are not limited to, difficulties
          or delays in development, testing, regulatory approval, production and
          marketing  of any of the  Company's  drug  candidates,  the failure to
          attract or retain  scientific  management  personnel,  any  unexpected
          adverse  side  effects  or  inadequate  therapeutic  efficacy  of  the
          Company's  drug  candidates   which  could  slow  or  prevent  product
          development  efforts,  competition  within the  Company's  anticipated
          product markets,  the Company's  dependence on corporate partners with
          respect to research and development  funding,  regulatory  filings and
          manufacturing  and marketing  expertise,  the  uncertainty  of product
          development  in  the  pharmaceutical  industry,  inability  to  obtain
          sufficient funds through future collaborative arrangements,  equity or
          debt  financings  or other  sources to continue  the  operation of the
          Company's business,  risk that patents and confidentiality  agreements
          will not  adequately  protect the Company's  intellectual  property or
          trade secrets,  dependence  upon third parties for the  manufacture of
          potential products, inexperience in manufacturing and lack of internal
          manufacturing  capabilities,  dependence  on third  parties  to market
          potential  products,   lack  of  sales  and  marketing   capabilities,
          potential  unavailability  or inadequacy of medical insurance or other
          third-party  reimbursement  for the cost of purchases of the Company's
          products,  and other risks  detailed in the Company's  Securities  and
          Exchange Commission filings,  including its Annual Report on Form 10-K
          for the year ended  December 31, 1999,  each of which could  adversely
          affect the Company's business and the accuracy of the  forward-looking
          statements contained herein.


















                                       14
<PAGE>




                                    Signature



               Pursuant to the  requirements  of the Securities  Exchange Act of
          1934,  the  registrant has duly caused this report to be signed on its
          behalf by the undersigned thereunto duly authorized.


                                                            NEUROGEN CORPORATION



                                               By:/s/   STEPHEN R. DAVIS
                                                  ------------------------
                                                    Stephen R. Davis
                                                    Senior Vice President
                                                    and Chief Business Officer

Date:  August 14, 2000

























                                       15
<PAGE>
                                  Exhibit Index
Exhibit
-------
Number
------

10.1    - Neurogen  Corporation Stock  Option Plan, as amended  (incorporated by
          reference  to Exhibit 10.1 to the  Company's  Form 10-K for the fiscal
          year ended December 31, 1991).

10.2    - Form of Stock Option  Agreement  currently used in connection with the
          grant  of  options  under  Neurogen   Corporation  Stock  Option  Plan
          (incorporated  by reference to Exhibit 10.2 to the Company's Form 10-K
          for the fiscal year ended December 31, 1992).

10.3    - Neurogen   Corporation   1993  Omnibus   Incentive  Plan,  as  amended
          (incorporated  by reference to Exhibit 10.3 to the Company's Form 10-K
          for the fiscal year ended December 31, 1993).

10.4    - Form of Stock Option  Agreement  currently used in connection with the
          grant of options under  Neurogen  Corporation  1993 Omnibus  Incentive
          Plan (incorporated  by reference to Exhibit 10.4 to the Company's Form
          10-K for the fiscal year ended December 31, 1993).

10.5    - Neurogen   Corporation   1993  Non-Employee   Directors  Stock  Option
          Program  (incorporated  by reference to Exhibit 10.5 to the  Company's
          Form 10-K for the fiscal year ended December 31, 1993).

10.6    - Form of Stock Option  Agreement  currently used in connection with the
          grant  of  options  under  Neurogen   Corporation  1993   Non-Employee
          Directors Stock Option Program  (incorporated  by reference to Exhibit
          10.6 to the Company's Form 10-K for the fiscal year ended December 31,
          1993).

10.7    - Employment  Contract  between the Company  and Harry H.  Penner,  Jr.,
          dated as of October 12, 1993  (incorporated  by  reference  to Exhibit
          10.7 to the Company's Form 10-K for the fiscal year ended December 31,
          1993).

10.8    - Employment Contract between the Company and John F. Tallman,  dated as
          of December 1, 1993 (incorporated by reference to Exhibit 10.25 to the
          Company's Form 10-Q for the quarterly period ended September 30,1994).

10.9    - Open-End Mortgage Deed and Security  Agreement between the Company and
          Orion   Machinery   &   Engineering   Corp.,   dated  March  16,  1989
          (incorporated  by reference to Exhibit 10.15 to Registration Statement
          No. 33-29709 on Form S-1).

10.10   - Form   of   Proprietary   Information    and    Inventions   Agreement
          (incorporated by reference to Exhibit 10.31 to Registration  Statement
          No. 33-29709 on Form S-1).

10.11   - Warrant  to  Purchase  47,058  Shares  of  Common  Stock  to  MMC/GATX
          Partnership No. I, dated February 20, 1991  (incorporated by reference
          to Exhibit 10.34 to the Company's  Form 10-K for the fiscal year ended
          December 31, 1990).

10.12   - Collaborative  Research  Agreement  and License and Royalty  Agreement
          between  the  Company  and  Pfizer  Inc,  dated as of  January 1, 1992
          (CONFIDENTIAL  TREATMENT  REQUESTED)  (incorporated  by  reference  to
          Exhibit  10.35 to the  Company's  Form 10-K for the fiscal  year ended
          December 31, 1991).

10.13   - License  Agreement  between  the  Company and the  National  Technical
          Information  Service,  dated as of  January 1, 1992  (incorporated  by
          reference to Exhibit 10.36 to the  Company's  Form 10-K for the fiscal
          year ended December 31, 1991).

10.14   - Cooperative Research and Development Agreement between the Company and
          the  National  Institutes  of  Health,  dated as of January  21,  1993
          (incorporated by reference to Exhibit 10.37 to the Company's Form 10-K
          for the fiscal year ended December 31, 1991).

10.15   - Letter Agreement between the Company and Barry M. Bloom, dated January
          12, 1994  (incorporated by reference to Exhibit 10.25 to the Company's
          Form 10-K for the fiscal year ended December 31, 1993).

10.16   - Letter  Agreement  between the Company and Robert H. Roth, dated April
          14, 1994  (incorporated by reference to Exhibit 10.26 to the Company's
          Form 10-K for the fiscal year ended December 31, 1994).


                                       16
<PAGE>




10.17   - Collaborative  Research  Agreement  and License and Royalty  Agreement
          between  the  Company  and  Pfizer  Inc,  dated  as of  July  1,  1994
          (CONFIDENTIAL  TREATMENT  REQUESTED)  (incorporated  by  reference  of
          Exhibit 10.1 to the Company's Form 10-Q for the quarterly period ended
          June 30, 1994).

10.18   - Stock  Purchase  Agreement  between the Company and Pfizer dated as of
          July  1,  1994  (incorporated  by  reference  to  Exhibit  10.2 to the
          Company's Form 10-Q for the quarterly period ended June 30, 1994).

10.19   - Registration Rights and Standstill Agreement among the Company and the
          Persons and  Entities  listed on Schedule I thereto,  dated as of July
          11, 1994 (incorporated  by reference to Exhibit 10.29 to the Company's
          Form 10-Q for the quarterly period ended September 30, 1994).

10.20   - Collaboration  and License  Agreement and Screening  Agreement between
          the Company and Schering-Plough  Corporation  (CONFIDENTIAL  TREATMENT
          REQUESTED) (incorporated by reference to Exhibit 10.1 to the Company's
          Form 8-K dated July 28, 1995).

10.21   - Lease Agreement between the Company and Commercial Building Associates
          dated as of August 30,  1995  (incorporated  by  reference  to Exhibit
          10.27  to  the  Company's Form  10-Q  for  the  quarterly period ended
          September 30, 1995).

10.22   - Collaborative  Research Agreement between the Company and Pfizer dated
          as  of    November   1,   1995    (CONFIDENTIAL  TREATMENT  REQUESTED)
          (incorporated by reference to Exhibit 10.1 of the  Company's Form 8-K
          dated November 1, 1995).

10.23   - Development and  Commercialization  Agreement  between the Company and
          Pfizer dated as of November 1, 1995 (CONFIDENTIAL TREATMENT REQUESTED)
          (incorporated  by  reference to Exhibit 10.2 of the Company's Form 8-K
          dated November 1, 1995).

10.24   - Stock  Purchase  Agreement  between the Company and Pfizer dated as of
          November  1, 1995  (incorporated  by   reference  to  Exhibit  10.3 of
          the Company's Form 8-K dated November 1, 1995).

10.25   - Licensing  Agreement dated  as of  November 25, 1996 between  American
          Home   Products   Corporation,   acting   through   its   Wyeth-Ayerst
          Laboratories   Division,   and  Neurogen   Corporation   (CONFIDENTIAL
          TREATMENT REQUESTED) (incorporated by reference to Exhibit 10.1 of the
          Company's Form 8-K dated March 31, 1997).

10.26   - Stock  Purchase  Agreement  dated  as of  November  25,  1996  between
          American Home Products  Corporation,  acting through its  Wyeth-Ayerst
          Laboratories   Division,   and  Neurogen   Corporation   (CONFIDENTIAL
          TREATMENT REQUESTED) (incorporated by reference to Exhibit 10.1 of the
          Company's Form 8-K dated March 31, 1997).

10.27   - Technology  Agreement  dated as of June 15, 1999  between  the Company
          and  Pfizer Inc (CONFIDENTIAL  TREATMENT  REQUESTED) (incorporated  by
          reference  to  Exhibit  10.27  to  the  Company's  Form  10-Q for  the
          quarterly period ended June 30, 1999).

10.28   - Employment  Contract  between the Company and Alan J. Hutchison, dated
          as of December 1, 1997  (incorporated  by  reference  to Exhibit 10.28
          to the  Company's Form 10-K  for the  fiscal year  ended  December 31,
          1999).


10.29   - Employment  Contract  between the Company  and Stephen R. Davis, dated
          as of December 1, 1997 (incorporated  by  reference  to Exhibit  10.29
          to the Company's Form  10-K for the  fiscal  year  ended  December 31,
          1999).

10.30   - Employment  Contract  between  the Company  and Kenneth R. Shaw, dated
          as of December 1, 1999  (incorporated  by  reference  to Exhibit 10.30
          to the  Company's Form  10-K for the  fiscal  year ended  December 31,
          1999).

                                       17
<PAGE>



10.31   - Neurogen Corporation 2000 Non-Employee Directors Stock Option Program.

10.32   - Form  of  Non-Qualified  Stock   Option  Agreement  currently  used in
          connection  with the grant of options  under the Neurogen  Corporation
          2000 Non-Employee Directors Stock Option Program.

10.33   - Registration Rights Agreement dated  as of  June 26, 2000  between the
          Company and the  Purchasers  listed on Exhibit A thereto.

27.1    - Financial Data Schedule










                                       18
<PAGE>

                                                                   EXHIBIT 10.31



                              NEUROGEN CORPORATION

                2000 NON-EMPLOYEE DIRECTORS STOCK OPTION PROGRAM

1.   Purpose.   The  purpose  of  the  Neurogen  Corporation  2000  Non-Employee
     Directors  Stock Option Program (the "Program") is to promote the interests
     of  Neurogen   Corporation   (the   "Company")  and  its   shareholders  by
     strengthening  the Company's  ability to attract and retain the services of
     experienced and knowledgeable non-employee directors through formula grants
     of  non-qualified  stock options to acquire the Company's Common Stock, par
     value $.025 per share.  In addition,  such grants will encourage the closer
     alignment of the  interests of such  directors  with those of the Company's
     shareholders.

2.   Definitions.  For purposes of the Program,  the following  terms shall have
     the meanings set forth below:

               2.1  "Annual  Grant"  shall have the meaning set forth in Section
                    4.3 of the Program.  2.2 "Annual  Meeting"  means the annual
                    meeting of the Company's shareholders for any fiscal year as
                    determined by the Company's By-Laws.

               2.3  "Award Agreement" means the stock option agreement  executed
                    by each of the Eligible Directors pursuant to Sections 4 and
                    10.3 of the Program in  connection  with the granting of the
                    options hereunder.

               2.4  "Board"  means the Board of  Directors  of the  Company,  as
                    constituted from time to time.

               2.5  "Change of Control" means

                    (i)  any individual,  entity or group (within the meaning of
                         Section  13(d)(3)  or  14(d)(2)  of the  Exchange  Act)
                         acquires,  as a result of any purchase or exchange,  or
                         any merger,  consolidation or other  reorganization,  a
                         majority of the outstanding voting securities or assets
                         of the Company or

                    (ii) the  Board or the  Company's  shareholders,  either  or
                         both, as may be required to authorize  the same,  shall
                         approve any  liquidation  or dissolution of the Company
                         or sale of all or  substantially  all of the  assets of
                         the Company.

               2.6  "Code" means the Internal Revenue Code of 1986, as in effect
                    and as amended from time to time, or any  successor  statute
                    thereto,   together   with  any   rules,   regulations   and
                    interpretations   promulgated  thereunder  or  with  respect
                    thereto.

               2.7  "Committee"  shall have the meaning set forth in Section 3.3
                    of the Program.

               2.8  "Common  Stock" means the Common Stock,  par value $.025 per
                    share,  of the Company or any security of the Company issued
                    by the Company in substitution or exchange therefor.

               2.9  "Company"   means   Neurogen    Corporation,    a   Delaware
                    corporation,   or  any  successor  corporation  to  Neurogen
                    Corporation.

               2.10 "Eligible  Director" means any Non-Employee  Director of the
                    Company who becomes a member of the Board.

               2.11 "Exchange Act" means the Securities Exchange Act of 1934, as
                    in effect and as amended from time to time, or any successor
                    statute  thereto,  together with any rules,  regulations and
                    interpretations   promulgated  thereunder  or  with  respect
                    thereto.

               2.12 "Fair Market  Value" means on, or with respect to, any given
                    date(s), the closing price for the Common Stock, as reported
                    on the NASDAQ National Market System for such date(s) or, if
                    the Common Stock was not traded on such date(s), on the next
                    preceding  day or days on which the Common Stock was traded.
                    If at any time the Common  Stock is not traded on the NASDAQ
                    National Market System,  the Fair Market Value of a share of
                    the Common  Stock shall be  determined  in good faith by the
                    Board.

               2.13 "Grant Date" means the date on which an Initial  Grant or an
                    Annual Grant is made to an Eligible Director.

               2.14 "Initial  Grant" shall have the meaning set forth in Section
                    4.2 of the Program.

               2.15 "Non-Employee  Director"  means any  director of the Company
                    who is not,  and who has not  been  for at  least  one  year
                    preceding the  commencement  of his or her membership on the
                    Board,  an  employee  of  the  Company,  or  any  parent  or
                    subsidiary companies of the Company.

               2.16 "Option  Period" shall have the meaning set forth in Section
                    4.7 of the Program.

               2.17 "Option  Shares" shall have meaning set forth in Section 3.2
                    of the Program.

               2.18 "Option(s)"  means the stock  option(s) to acquire shares of
                    Common Stock granted pursuant to the provisions of Section 4
                    of the Program and the relevant Award Agreement.

               2.19 "Program" means the Neurogen  Corporation 2000  Non-Employee
                    Directors Stock Option  Program,  as set forth herein and as
                    in effect and as amended  from time to time  (together  with
                    any rules and  regulations  promulgated  by the Committee in
                    accordance with Section 3.4 of the Program).

               2.20 "Reelected   Director"   means  an  Eligible   Director  who
                    previously received an Initial Grant,  terminated service as
                    a director  of the Company  and is  subsequently  elected or
                    appointed to the Board.

               2.21 "SEC" means the Securities and Exchange  Commission,  or any
                    successor governmental agency.

               2.22 "SEC Rule 16b-3" means Rule 16b-3, as promulgated by the SEC
                    under  Section  16(b) of the Exchange  Act, or any successor
                    rule or  regulation  thereto,  as such  Rule is  amended  or
                    applied from time to time.

               2.23 "Subsidiary(ies)"  means  any  corporation  (other  than the
                    Company) in an unbroken chain of corporations, including and
                    beginning  with the Company,  if each of such  corporations,
                    other than the last corporation in the unbroken chain, owns,
                    directly or indirectly, more than fifty percent (50%) of the
                    voting stock in one of the other corporations in such chain.

               2.24 "Termination"  means a termination of an Eligible Director's
                    membership on the Board.

3.   Term of the Program; Common Stock Subject to the Program; Administration.

               3.1  Term.  The  Program  shall  continue  in effect  until it is
                    terminated  by  action  of the  Board  or of  the  Company's
                    shareholders,  but any such termination shall not affect the
                    terms of any then outstanding Options.

               3.2  Common Stock.  The maximum  number of shares of Common Stock
                    in  respect  of  which  Options  may be  granted  under  the
                    Program, subject to adjustment as provided in Section 8.2 of
                    the Program, shall not exceed two hundred thousand (200,000)
                    shares (the  "Option  Shares").  In the event of a change in
                    the Common  Stock of the Company that is limited to a change
                    in the  designation  thereof  to  "Capital  Stock"  or other
                    similar  designation,  or  to a  change  in  the  par  value
                    thereof, or from par value to no par value, without increase
                    or  decrease  in the  number of issued  shares,  the  shares
                    resulting  from any such  change  shall be  deemed to be the
                    Common Stock for purposes of the Program. Common Stock which
                    may be issued under the Program may be either authorized and
                    unissued  shares or issued shares which have been reacquired
                    by  the   Company   (in  the  open   market  or  in  private
                    transactions)  and which are being held as treasury  shares.
                    No  fractional  shares of Common Stock shall be issued under
                    the Program. If any Option granted under the Program expires
                    or terminates  for any reason  without having been exercised
                    in full,  the Option  Shares  subject to, but not  delivered
                    under, any such Option may become available for the grant of
                    other Options under the Program.

               3.3  The  Committee.  Subject to the terms and  provisions of the
                    Program,  the Program shall be  administered  by a committee
                    selected by the Board (the "Committee").

               3.4  Program  Administration  and Program  Rules.  The  Committee
                    shall have the power to interpret and construe the terms and
                    provisions of the Program, to determine questions that arise
                    thereunder, to designate persons to carry out the day-to-day
                    ministerial   administration   of  the  Program  under  such
                    conditions  and  limitations  as it  may  prescribe,  and to
                    promulgate,   adopt,   amend  and  rescind  such  rules  and
                    regulations for implementing and  administering  the Program
                    as  the  Committee   deems   necessary  or  desirable.   Any
                    determination,  decision  or  action  of  the  Committee  in
                    connection    with   the    construction,    interpretation,
                    administration  or  implementation  of the Program  shall be
                    final,  binding and conclusive  upon all Eligible  Directors
                    and any  person(s)  claiming  under or through any  Eligible
                    Directors.

4.   Non-Qualified Stock Option Grants.

               4.1  Term.  All  Options  granted  under  the  Program  shall  be
                    nonstatutory  options that are not "incentive stock options"
                    within the meaning of Section 422 of the Code.

               4.2  Initial  Grant.  An initial  Option to acquire five thousand
                    (5,000)  Option Shares (as adjusted  pursuant to Section 8.2
                    of the  Program)  shall be granted (an  "Initial  Grant") to
                    each  Eligible  Director  immediately  following  any Annual
                    Meeting at which such Eligible  Director is first elected by
                    the Company's shareholders or when such Eligible Director is
                    otherwise  first  elected or  appointed by the Board to be a
                    director, whichever is applicable; provided, however, that a
                    Reelected Director shall not receive a second Initial Grant.

               4.3  Annual  Grant.  An annual  Option to acquire  five  thousand
                    (5,000)  Option Shares (as adjusted  pursuant to Section 8.2
                    of  the  Program)  shall  be  granted  (an  "Annual  Grant")
                    automatically  each year on the anniversary of each Eligible
                    Director's    election,    reelection,     appointment    or
                    reappointment to the Board.

               4.4  Exercise  Price.  The option exercise price per Option Share
                    for an Initial  Grant and an Annual  Grant shall be the Fair
                    Market Value on the Grant Date.

               4.5  Method of Exercise.  Upon becoming exercisable in accordance
                    with Section 5 of the Program, an Option may be exercised in
                    whole or in part at any time  and from  time to time  during
                    the Option  Period by giving  written  notice of exercise to
                    the  Secretary  of the Company or the  Secretary's  designee
                    specifying  the number of Option  Shares in respect of which
                    the  Option  is  being  exercised.   Such  notice  shall  be
                    accompanied  by  payment  in  full of the  aggregate  option
                    exercise  price for the Option  Shares to be  acquired.  The
                    date both such notice and payment are received by the office
                    of the  Secretary  of the  Company  shall  be  the  date  of
                    exercise of the Option as to such  number of Option  Shares.
                    No  Option  may be  exercised  at any time in  respect  of a
                    fractional share.

               4.6  Form of Payment.  Payment of the aggregate  option  exercise
                    price may be in cash or by certified,  cashier's or personal
                    check.  Payment  may also be made in whole or in part by the
                    transfer  to the Company of shares of Common  Stock  already
                    owned by an  Eligible  Director  for at least six months and
                    having a Fair Market  Value equal to all or a portion of the
                    option exercise price at the time of such exercise.

               4.7  Option  Period.  Each Option shall expire ten years from its
                    Grant Date (the "Option Period");  provided,  however in the
                    event  of  the  Termination  of an  Eligible  Director,  any
                    outstanding  unexercised  Option of such  Eligible  Director
                    that has not vested  pursuant  to  Section 5 of the  Program
                    shall be deemed to be vested and shall be  exercisable  upon
                    the  effectiveness  of such  Termination and all outstanding
                    and unexercised  Options of such Eligible  Director (whether
                    such Options vested prior to or at Termination) shall expire
                    one (1) year  after the date of any such  Termination  or on
                    the stated grant expiration date, whichever is earlier.

               4.8  Right to Exercise.  The right of any  Eligible  Director (or
                    any  person  or entity  receiving  a  transfer  of an Option
                    directly  from an Eligible  Director as permitted in Section
                    10.5(b))  to exercise  an Option  granted  under the Program
                    shall,  during the  lifetime of such  Eligible  Director (or
                    direct  transferee)  be  exercisable  only by such  Eligible
                    Director (or transferee) and shall not be assignable by such
                    Eligible  Director (or transferee) other than by will or the
                    laws of descent and distribution or by the Eligible director
                    pursuant to Section 10.5(b).

               4.9  Limitation  of Rights.  Neither the  recipient  of an Option
                    under the Program nor an Eligible  Director's  transferee or
                    successor or successors in interest shall have any rights as
                    a  shareholder  of the  Company  with  respect to any Option
                    Shares subject to an Option granted to such person until the
                    date of issuance of a stock  certificate  in respect of such
                    Option Shares.

               4.10 Regulatory  Approval.  The Company  shall not be required to
                    issue any certificate or certificates for Option Shares upon
                    the  exercise of an Option  granted  under the Program or to
                    record as a holder of  record of Option  Shares  the name of
                    the  individual  exercising  an Option  under  the  Program,
                    without  obtaining  to  the  complete  satisfaction  of  the
                    Committee  the approval of all  regulatory  bodies,  if any,
                    deemed necessary by the Committee and without complying,  to
                    the Committee's  complete  satisfaction,  with all rules and
                    regulations  under  federal,  state,  or  local  law  deemed
                    applicable by the Committee.

5.   Vesting.  Subject to Section 4.7 and Section 6 of the Program,  one-twelfth
     (1/12) of each  Option  (in  respect  of the  aggregate  underlying  Option
     Shares) shall become  exercisable on the last day of each month,  beginning
     the last day of the month in which such Option Shares were granted.

6.   Acceleration of Vesting Upon Change of Control.  Anything in the Program to
     the contrary notwithstanding,  if a Change of Control of the Company occurs
     all Options then unexercised and outstanding  shall become fully vested and
     exercisable  as of the  date of the  Change  of  Control.  The  immediately
     preceding  sentence  shall apply to only those  Eligible  Directors who are
     members of the Board as of the date of the Change of Control.

7.   Tax  Reimbursement.  All taxes, if any, in respect of any Option(s) granted
     hereunder  to  the   Eligible   Director   hereunder   shall  be  the  sole
     responsibility of and shall be paid by the Eligible Director.

8.   Changes in Capitalization and Other Matters.

               8.1  No  Corporate  Action  Restriction.  The  existence  of  the
                    Program,  any Award Agreement and/or the formula grants made
                    hereunder shall not limit, affect or restrict in any way the
                    right  or  power of the  Board  or the  shareholders  of the
                    Company   to  make   or   authorize

                    (a)  any  adjustment,  recapitalization,  reorganization  or
                         other  change  in the  Company's  or  any  Subsidiary's
                         capital structure or its business,

                    (b)  any merger, consolidation or change in the ownership of
                         the Company or any Subsidiary,

                    (c)  any  issue  of  secured  or   unsecured   indebtedness,
                         capital,  preferred or prior preference stocks ahead of
                         or affecting the Company's or any Subsidiary's  capital
                         stock or the rights thereof,

                    (d)  any  dissolution  or  liquidation of the Company or any
                         Subsidiary,

                    (e)  any  sale  or  transfer  of  all  or  any  part  of the
                         Company's or any Subsidiary's assets or business, or

                    (f)  any other corporate act or proceeding by the Company or
                         any Subsidiary.

                    An Eligible Director,  any transferee or beneficiary(ies) of
                    any such  Eligible  Director or any other  person  shall not
                    have  any  claim  against  any  member  of the  Board or any
                    committee  thereof,  the  Company or any  Subsidiary  or any
                    employees,   officers  or  agents  of  the  Company  or  any
                    Subsidiary, as a result of any such action.

               8.2  Recapitalization  Adjustments. In the event of any change in
                    capitalization   affecting  the  Common  Stock,   including,
                    without limitation,  a stock dividend or other distribution,
                    stock  split,   reverse   stock   split,   recapitalization,
                    consolidation,   merger,  subdivision,  split-up,  spin-off,
                    split-off,  combination  or exchange of shares or other form
                    of reorganization or  recapitalization,  or any other change
                    affecting   the  Common   Stock  (any  of  these   being  an
                    "Adjustment  Event"), the Committee may make such adjustment
                    as it deems  appropriate to reflect such change,  including,
                    without limitation, with respect to the aggregate number and
                    class of shares of the  Common  Stock (or number and kind of
                    other  securities or property)  subject to and authorized by
                    the Program,  the number and class of shares of Common Stock
                    (or  number and kind of other  securities  or  property)  in
                    respect of which an Option  may be  granted  to an  Eligible
                    Director  under the  Program as  provided  in Section 4, the
                    number  and class of Option  Shares  (or  number and kind of
                    other  securities  or  property)   subject  to  each  Option
                    outstanding   and  the  per  share  (or  other  security  or
                    property)   exercise   price   specified   for  each  Option
                    outstanding.  In addition,  upon an  Adjustment  Event,  the
                    Committee  may  cancel  any or all  outstanding  Options  in
                    exchange  for a payment in respect of each such Option equal
                    to the  product  of

                    (a)  the excess of

                         (i)  the fair market value  of a share at the  time  of
                              the Adjustment Event over

                         (ii) the per share exercise price of such Option and

                    (b)  the number of shares subject to such Option.

9.   Amendment;  Termination. The Board may suspend or terminate the Program (or
     any portion  thereof) at any time and may amend the Program at any time and
     from  time to time  in such  respects  as the  Board  may  deem  advisable;
     provided,  however,  that the terms and  provisions  of the  Program  which
     determine the eligibility of directors and the amount,  price and timing of
     the formula grants  hereunder shall not be amended more than once every six
     months,  other than to  comport  with  changes in the Code or the  Employee
     Retirement  Income  Security  Act  of  1974,  as  amended,  and  the  rules
     thereunder;  provided, further, that without majority shareholder approval,
     no such  amendment  shall

                    (a)  except  as  provided  in  Section  8.2 of the  Program,
                         materially  increase  the  number  of  shares of Common
                         Stock which may be issued under the Program,

                    (b)  modify in any way the  requirements  as to  eligibility
                         for grants under the Program, or

                    (c)  increase  the benefits  accruing to Eligible  Directors
                         under the  Program.  In  addition,  no such  amendment,
                         suspension  or  termination  shall be  effective  if it
                         would  materially  adversely  affect  the rights of any
                         Eligible Director in respect of any outstanding Option,
                         without the consent of such Eligible Director.

10.  Miscellaneous.

               10.1 No Right to Continue as  Director.  Neither the  adoption of
                    the Program, the granting of an Option, nor any other action
                    taken  pursuant  to  the  Program  shall  constitute  or  be
                    evidence  of any  agreement  or  understanding,  express  or
                    implied,  that an Eligible  Director has a right to continue
                    as a director  of the  Company  for any period of time or at
                    any particular rate of remuneration.

               10.2 Listing, Registration and Other Legal Compliance. No Options
                    or Common  Stock shall be issued  under the  Program  unless
                    legal counsel for the Company  shall be satisfied  that such
                    issuance will be in compliance  with all applicable  federal
                    and  state  securities  laws and  regulations  and any other
                    applicable laws or regulations.  The Company may require, as
                    a condition of any payment or share  issuance,  that certain
                    agreements,  undertakings,   representations,   certificates
                    and/or  information,  as the Company may deem  necessary  or
                    advisable,  in its sole discretion,  be executed or provided
                    to the Company to assure compliance with all such applicable
                    laws or  regulations.  Certificates  for any Options  and/or
                    Common Stock  delivered  under the Program may be subject to
                    such  stock-transfer  orders and such other  restrictions as
                    the Company may deem advisable under the rules,  regulations
                    or other requirements of the SEC, any stock exchange upon or
                    trading  system in which the Common  Stock is then listed or
                    traded and any applicable  federal or state  securities law.
                    In  addition,  if, at any time  specified  herein (or in any
                    Award  Agreement or otherwise) for

                    (a)  the  issuance  or  other  distribution  of any  Options
                         and/or Common Stock or

                    (b)  the payment of amounts to any  Eligible  Director,

                    any  law,  rule,  regulation  or  other  requirement  of any
                    governmental  authority or agency shall  require  either the
                    Company,  any  Subsidiary  or any Eligible  Director (or any
                    estate, designated beneficiary or other legal representative
                    thereof,  as  the  case  may be  and  as  determined  by the
                    Committee)  to take any action in  connection  with any such
                    determination,  any Options to be issued or distributed, any
                    such payment or the making of any such determination, as the
                    case may be, shall be deferred until such required action is
                    taken.  The Program and all  transactions  under the Program
                    are intended to comply with all applicable conditions of SEC
                    Rule 16b-3. To the extent any provision of the Program fails
                    to so comply  with such  rule,  it shall be deemed  null and
                    void, to the extent permitted by law and deemed advisable by
                    the Company.

               10.3 Award  Agreements.  Each  Eligible  Director  shall,  at the
                    request of the Company,  enter into an Award  Agreement with
                    the Company in a form  specified by the  Company.  Each such
                    Eligible Director shall agree to the restrictions, terms and
                    conditions  set forth in such  Award  Agreement  and/or  the
                    Program.

               10.4 Designation  of  Beneficiary.  Each  Eligible  Director  may
                    designate  a  beneficiary  or  beneficiaries  to exercise an
                    Option or to receive  any  payment  which under the terms of
                    the  Program and the  relevant  Award  Agreement  may become
                    exercisable  or payable on or after the Eligible  Director's
                    death.  At any  time,  and  from  time  to  time,  any  such
                    designation  may be changed  or  cancelled  by the  Eligible
                    Director  without the consent of any such  beneficiary.  Any
                    such  designation,  change or cancellation must be on a form
                    provided  for that  purpose by the  Company and shall not be
                    effective  until received by the Company.  If no beneficiary
                    has been designated by a deceased Eligible  Director,  or if
                    the designated  beneficiaries  have predeceased the Eligible
                    Director,  the beneficiary shall be the Eligible  Director's
                    estate.  If the Eligible  Director  designates more than one
                    beneficiary,   any  payments   under  the  Program  to  such
                    beneficiaries  shall  be made in  equal  shares  unless  the
                    Eligible  Director has expressly  designated  otherwise,  in
                    which  case  the  payments  shall  be  made  in  the  shares
                    designated by the Eligible Director.

               10.5 Non-transferability  of  Awards.

                    (a)  Except as  otherwise  provided in clause (b) below,  no
                         Option under the Program or any Award Agreement, and no
                         rights or interests herein or therein,  shall or may be
                         assigned,  transferred,  sold,  exchanged,  encumbered,
                         pledged or otherwise hypothecated or disposed of by any
                         Eligible  Director  or  any   beneficiary(ies)  of  any
                         Eligible Director,  except by testamentary  disposition
                         by the  Eligible  Director  or the  laws  of  intestate
                         succession.  No  such  interest  shall  be  subject  to
                         execution,   attachment  or  similar   legal   process,
                         including, without limitation,  seizure for the payment
                         of an Eligible Director's debts, judgements, alimony or
                         separate  maintenance.  Any attempt to sell,  exchange,
                         transfer, assign, pledge, encumber or otherwise dispose
                         of or hypothecate in any way any such awards, rights or
                         interests or the levy of any  execution,  attachment or
                         similar legal process thereon, contrary to the terms of
                         this Program  shall be null and void and without  legal
                         force or effect.

                    (b)  During the Eligible Director's  lifetime,  the Eligible
                         Director  may,  with  the  consent  of  the  Committee,
                         transfer without consideration all or any portion of an
                         Option to one or more  members of his or her  Immediate
                         Family (as defined below),  to a trust  established for
                         the exclusive  benefit of one or more members of his or
                         her Immediate Family, to a partnership in which all the
                         partners are members of his or her Immediate Family, or
                         to a limited liability company in which all the members
                         are members of his or her Immediate  Family;  provided,
                         however,   that  any  such  Immediate  Family,   trust,
                         partnership or limited liability company shall agree to
                         be and shall be bound by the terms  and  provisions  of
                         the  Program,  and by the terms and  provisions  of any
                         applicable   outstanding   Award  Agreements  or  other
                         agreements  covering the Options or the shares  subject
                         to  the  options.   For  purposes  of  this  Agreement,
                         "Immediate   Family"  means  the  Eligible   Director's
                         children,   stepchildren,    grandchildren,    parents,
                         stepparents,  grandparents, spouse, siblings (including
                         half-brothers and half-sisters),  in-laws, and all such
                         relationships arising because of legal adoption.

               10.6 Governing Law. The Program and all actions taken  thereunder
                    shall be governed by and  construed in  accordance  with the
                    laws of the  State of  Delaware,  without  reference  to the
                    principles  of  conflict  of laws  thereof.  Any  titles and
                    headings  herein are for reference  purposes only, and shall
                    in no way limit,  define or  otherwise  affect the  meaning,
                    construction  or  interpretation  of any  provisions  of the
                    Program.

               10.7 Effective  Date.  The Program  shall be  effective  upon its
                    adoption  by  the  Board,  subject  to the  approval  of the
                    Program by the Company's shareholders.
<PAGE>


                                                                   EXHIBIT 10.32

                      NON-QUALIFIED STOCK OPTION AGREEMENT
                                 pursuant to the
                              NEUROGEN CORPORATION
                2000 NON-EMPLOYEE DIRECTORS STOCK OPTION PROGRAM



          Optionee:
          Grant Date:
          Per Share Exercise Price:
          Number of Option Shares subject to this Option:

               THIS  NON-QUALIFIED  STOCK OPTION  AGREEMENT (this  "Agreement"),
          dated as of the Grant Date  specified  above,  is entered  into by and
          between Neurogen Corporation,  a Delaware Corporation (the "Company"),
          and the Optionee specified above, pursuant to the Neurogen Corporation
          2000 Non-Employee  Directors Stock Option Program, as in effect and as
          amended from time to time (the "Program"); and

               WHEREAS,  it has been determined  under the Program that it would
          be in the best  interests  of the Company to grant  automatically  the
          non-qualified stock option provided for herein to the Optionee;

               NOW,  THEREFORE,  in  consideration  of the mutual  covenants and
          premises  hereinafter  set  forth  and for  other  good  and  valuable
          considerations, the parties hereto hereby mutually convenant and agree
          as follows:

               1.  Incorporation By Reference:  Program Document  Receipt.  This
          agreement is subject in all respect to the terms and provisions of the
          Program (including, without limitation, any amendments thereto adopted
          at any time and from  time to time if such  amendments  are  expressly
          intended to apply to the grant of the option hereunder),  all of which
          terms  and  provisions  are  made a part of and  incorporated  in this
          Agreement  as if they  were  each  expressly  set  forth  herein.  Any
          capitalized  term not  defined in this  Agreement  shall have the same
          meaning as is ascribed thereto under the Program.  The Optionee hereby
          acknowledges  receipt  of a true  copy of the  Program  and  that  the
          Optionee  has read the Program  carefully  and fully  understands  its
          content.  In the  event  of any  conflict  between  the  terms of this
          Agreement and the terms of the Program, the terms of the Program shall
          control.

               2. Grant of Option. The Company hereby grants to the Optionee, as
          of the Grant Date specified above, a non-qualified  stock option (this
          "Option") to acquire from the Company at the Per Share  Exercise Price
          specified  above the  aggregate  number of shares of the Common  Stock
          specified  above  (the  "Option  Shares").  This  Option  is not to be
          treated as (and is not  intended  to qualify  as) an  incentive  stock
          option within the meaning of Section 4.22 of the Code.

               3. Exercise of this Option.

                    3.1 This Option shall become  exercisable in accordance with
               and to the extent provided by the terms and provisions of Section
               5 of the Program.

                    3.2 Unless earlier  terminated in accordance  with the terms
               and provisions of the Program, this Option shall expire and shall
               no longer be  exercisable  after the expiration of ten years from
               the Grant Date (the "Option Period").

                    3.3 In no event  shall  this  Option  be  exercisable  for a
               fractional share of Common Stock.

               4. Method of Exercise and Payment. This Option shall be exercised
          by the Optionee by  delivering  to the Secretary of the Company or his
          or her designated  agent on any business day (the  "Exercise  Date") a
          written  notice,  in such  manner and form as may be  required  by the
          Company,  specifying the number of the Option Shares the Optionee then
          desires to acquire (the "Exercise Notice").  The Exercise Notice shall
          be  accompanied by payment in full of the aggregate Per Share Exercise
          Price for such number of the Option  Shares to be  acquired  upon such
          exercise.  Such  payment  shall  be made in the  manner  set  forth in
          Section 4.6 of the Program.
<PAGE>

               5. Termination. This Option shall terminate and be of no force or
          effect in accordance  with and to the extent provided by the terms and
          provisions  of Section 4.7 of the Program.  In any event,  this option
          shall terminate upon the expiration of the Option Period.

               6. Non-transferability.  This Option, and any rights or interests
          therein,  shall  not be  sold,  exchanged,  transferred,  assigned  or
          otherwise  disposed of in any way at any time by the  Optionee (or any
          beneficiary  (ies)  of  the  Optionee),  other  than  by  testamentary
          disposition by the Optionee or the laws of intestate succession.  This
          Option shall not be pledged,  encumbered or otherwise  hypothecated in
          any way at any time by the Optionee (or any beneficiary  (ies) of

          the  Optionee)  and shall not be subject to  execution,  attachment or
          similar  legal  process.  Any  attempt  to  sell,  exchange,   pledge,
          transfer, assign, encumber or otherwise dispose of or hypothecate this
          Option in any way, or the levy of any execution, attachment or similar
          legal  process  upon  this  Option,  contrary  to the  terms  of  this
          Agreement  and/or the Program shall be null and void and without legal
          force  or  effect.   This  Option  shall  be  exercisable  during  the
          Optionee's lifetime only by the Optionee.

               7. Entire  Agreement:  Amendment.  This  Agreement  contains  the
          entire  agreement  between  the  parties  hereto  with  respect to the
          subject matter contained  herein,  and supersedes all prior agreements
          or prior understandings,  whether written or oral, between the parties
          relating to such subject  matter.  This Agreement may only be modified
          or amended by a writing-signed by both the Company and the Optionee.

               8.  Notices.  Any  Exercise  Notice or other  notice which may be
          required or permitted  under this Agreement  shall be in writing,  and
          shall be delivered in person or via facsimile transmission,  overnight
          courier service or certified mail, return receipt  requested,  postage
          prepaid, properly addressed as follows.

                    8.1 If such notice is to the  Company,  to the  Attention of
               the secretary of Neurogen  Corporation,  35 Northeast  Industrial
               Road,  Branford,  Connecticut  06405, or at such other address as
               the  Company,  by  notice to the  Optionee,  shall  designate  in
               writing from time to time.

                    8.2 If such notice is to the Optionee, at his or her address
               as shown on the  Company's  records,  or at such other address as
               the  Optionee,  by  notice to the  Company,  shall  designate  in
               writing from time to time.

               9.  Governing  Law.  This  Agreement  shall  be  governed  by and
          construed  in  accordance  with  the laws of the  State  of  Delaware,
          without  reference to the principles of conflict of laws thereof.

               10.  Compliance  wiith Laws. The issuance of this Option (and the
          Option Shares upon exercise of this Option) pursuant to this Agreement
          shall  be  subject  to,  and  shall   comply  with,   any   applicable
          requirements  of any  federal  and state  securities  laws,  rules and
          regulations  (including,  without  limitation,  the  provisions of the
          Securities  Act  of  1933,  as  amended,  the  Exchange  Act  and  the
          respective rules and regulations promulgated thereunder) and any other
          law  or  regulation  applicable  thereto.  The  company  shall  not be
          obligated to issue this Option or any of the Option Shares pursuant to
          this   Agreement  if  any  such   issuance   would  violate  any  such
          requirements.

               11. Binding Agreement:  Assignment. This Agreement shall inure to
          the benefit of, be binding upon, and be enforceable by the Company and
          its successors and assigns.  The Optionee shall not assign any part of
          this  Agreement  without  the prior  express  written  consent  of the
          Company.


<PAGE>


               12.  Counterparts.  This Agreement may be executed in one or more
          counterparts, each of which shall be deemed to be an original, but all
          of which shall constitute one and the same instrument.

               13.  Headings.  The titles and heading of the various sections of
          this  Agreement  have been inserted for  convenience of reference only
          and shall not be deemed to be a part of this Agreement.

               14.  Further  Assurances.  Each party hereto shall do and perform
          (or shall cause to be done and  performed)  all such  further acts and
          shall  execute and deliver  all such other  agreements,  certificates,
          instruments  and documents as any party hereto  reasonably may request
          in order to carry out the intent and  accomplish  the purposes of this
          Agreement  and the Program and the  consummation  of the  transactions
          contemplated thereunder.

               15.  Severability.  The  invalidity  or  unenforceability  of any
          provisions of this Agreement in any jurisdiction  shall not affect the
          validity,   legality  or  enforceability  of  the  remainder  of  this
          Agreement  in  such   jurisdiction   or  the  validity,   legality  or
          enforceability  of any  provision  of  this  Agreement  in  any  other
          jurisdiction, it being intended that all rights and obligations of the
          parties hereunder shall be enforceable to the fullest extent permitted
          by law.

               IN WITNESS  WHEREOF,  the Company has caused this Agreement to be
          executed by its duly authorized officer, and the Optionee has hereunto
          set his hand, all as of the Grant Date specified above.

                                                      NEUROGEN CORPORATION



                                           By: _________________________________
                                               Stephen R. Davis
                                               Senior Vice President and Chief
                                               Business Officer


                                               _________________________________
                                               Optionee










<PAGE>



                                                                   EXHIBIT 10.33

                          REGISTRATION RIGHTS AGREEMENT

               This REGISTRATION  RIGHTS AGREEMENT (this "Agreement") is made as
          of June 26,  2000 by and among (i)  Neurogen  Corporation,  a Delaware
          corporation  (the  "Company"),  (ii) each  person  listed on Exhibit A
          attached  hereto  (collectively,  the  "Initial  Investors"  and  each
          individually,  an "Initial Investor"), and (iii) each person or entity
          that subsequently  becomes a party to this Agreement  pursuant to, and
          in accordance with, the provisions of Section 12 hereof (collectively,
          the  "Investor   Permitted   Transferees"  and  each  individually  an
          "Investor Permitted Transferee").

               WHEREAS,  the Company has agreed to issue and sell to the Initial
          Investors,  and the Initial Investors have agreed to purchase from the
          Company,  1,638,000  shares (the "Purchased  Shares") of the Company's
          common  stock,  $0.025 par value per share (the "Common  Stock"),  all
          upon the terms and conditions set forth in that certain Stock Purchase
          Agreement,  dated of even date  herewith,  between the Company and the
          Initial Investors (the "Stock Purchase Agreement"); and

               WHEREAS,  the terms of the Stock Purchase  Agreement provide that
          it shall be a condition  precedent to the closing of the  transactions
          thereunder,  for the Company and the Initial  Investors to execute and
          deliver this Agreement.

               NOW,  THEREFORE,  in  consideration  of the  premises  and mutual
          covenants  contained  herein,  the  parties  hereto  hereby  agree  as
          follows:

               1.  DEFINITIONS.  The  following  terms  shall have the  meanings
          provided  therefor  below or elsewhere in this  Agreement as described
          below:

               "Board" shall mean the board of directors of the Company.

               "Closing"  shall have the  meaning  ascribed  to such term in the
          Stock Purchase Agreement.

               "Exchange Act" shall mean the Securities Exchange Act of 1934, as
          amended, and all of the rules and regulations promulgated thereunder.

               "Investors" shall mean,  collectively,  the Initial Investors and
          the Investor Permitted Transferees;  provided,  however, that the term
          "Investors"  shall not include any of the Initial  Investors or any of
          the  Investor  Permitted  Transferees  that  ceases to own or hold any
          Purchased Shares.

               "Majority  Holders" shall mean, at the relevant time of reference
          thereto,  those Investors  holding and/or having the right to acquire,
          as the case may be, more than fifty percent  (50%) of the  Registrable
          Shares held by all of the Investors.

               "Qualifying  Holder" shall have the meaning  ascribed  thereto in
          Section 12 hereof.

               "Registrable  Shares" shall mean the Purchased Shares,  provided,
          however,  such  term  shall  not,  after  the  Mandatory  Registration
          Termination  Date,  include any of the Purchased Shares that become or
          have become  eligible  for resale  pursuant to Rule 144 or pursuant to
          Regulation S.

               "Regulation  S" shall mean  Regulation  S  promulgated  under the
          Securities Act and any successor or substitute rule, law or provision.

               "Rule 144" shall mean Rule 144  promulgated  under the Securities
          Act and any successor or substitute rule, law or provision.

               "SEC" shall mean the Securities and Exchange Commission.

               "Securities  Act"  shall  mean the  Securities  Act of  1933,  as
          amended, and all of the rules and regulations promulgated thereunder.

               2.  EFFECTIVENESS;   TERMINATION.  This  Agreement  shall  become
          effective  and  legally  binding  only  if the  Closing  occurs.  This
          Agreement  shall  terminate  and be of no  further  force  or  effect,
          automatically  and  without  any action  being  required  of any party
          hereto,  upon the termination of the Stock Purchase Agreement pursuant
          to Section 7 thereof.

               3. MANDATORY REGISTRATION.

               (a) Within ten (10) business days after the Closing,  the Company
          will  prepare and file with the SEC a  registration  statement on Form
          S-3 for the purpose of registering under the Securities Act all of the
          Registrable  Shares  for  resale  by,  and for  the  account  of,  the
          Investors  as  selling  stockholders   thereunder  (the  "Registration
          Statement").  The Registration Statement shall permit the Investors to
          offer and sell, on a delayed or continuous  basis pursuant to Rule 415
          under the Securities  Act, any or all of the Registrable  Shares.  The
          Company  agrees to use  reasonable  efforts to cause the  Registration
          Statement  to become  effective  as soon as  practicable.  The Company
          shall be required to keep the Registration  Statement  effective until
          such  date  that  is the  earlier  of (i)  the  date  when  all of the
          Registrable  Shares registered  thereunder shall have been sold or are
          eligible  for resale  pursuant  to Section (k) of Rule 144 or (ii) the
          second  anniversary of the Closing,  subject to extension as set forth
          below (such date is referred to herein as the "Mandatory  Registration
          Termination  Date").  Thereafter,  the  Company  shall be  entitled to
          withdraw the  Registration  Statement and the Investors  shall have no
          further right to offer or sell any of the Registrable  Shares pursuant
          to the Registration Statement (or any prospectus relating thereto). In
          the event the right of the selling  Investors to use the  Registration
          Statement  (and  the  prospectus   relating  thereto)  is  delayed  or
          suspended  pursuant  to  Sections  5(c) or 11  hereof  for a period in
          excess  of 60 days,  the  Company  shall be  required  to  extend  the
          Mandatory Registration  Termination Date beyond the second anniversary
          of the Closing by the same number of days as such delay or  Suspension
          Period (as defined in Section 11 hereof).

               (b) The offer and sale of the Registrable  Shares pursuant to the
          Registration Statement shall not be underwritten.

               4. "PIGGYBACK" REGISTRATION RIGHTS.

               (a) If, at any time after the Mandatory Registration  Termination
          Date,  the Company  proposes to register any of its Common Stock under
          the  Securities  Act,  whether as a result of a primary  or  secondary
          offering of Common Stock or pursuant to registration rights granted to
          holders of other securities of the Company (but excluding in all cases
          any  registrations  to be  effected  on  Forms  S-4 or  S-8  or  other
          applicable  successor Forms),  the Company shall, each such time, give
          to the Investors  holding  Registrable  Shares  written  notice of its
          intent to do so. Upon the written  request of any such Investor  given
          within 20 days after the giving of any such notice by the Company, the
          Company shall use  reasonable  efforts to cause to be included in such
          registration the Registrable  Shares of such selling Investor,  to the
          extent  requested to be  registered;  provided  that (i) the number of
          Registrable  Shares  proposed to be sold by such  selling  Investor is
          equal to at least  seventy-five  percent  (75%) of the total number of
          Registrable Shares then held by such  participating  selling Investor,
          (ii) such  selling  Investor  agrees to sell those of its  Registrable
          Shares to be included in such  registration  in the same manner and on
          the same  terms and  conditions  as the other  shares of Common  Stock
          which the Company proposes to register,  and (iii) if the registration
          is to include shares of Common Stock to be sold for the account of the
          Company or any party exercising demand registration rights pursuant to
          any  other   agreement  with  the  Company,   the  proposed   managing
          underwriter  does not  advise  the  Company  that in its  opinion  the
          inclusion of such selling  Investor's  Registrable Shares (without any
          reduction  in the  number of shares to be sold for the  account of the
          Company or such party exercising demand registration rights) is likely
          to affect  materially and adversely the success of the offering or the
          price that would be received for any shares of Common  Stock  offered,
          in which case the rights of such selling Investor shall be as provided
          in Section 4(b) hereof.

               (b) If a registration pursuant to Section 4(a) hereof involves an
          underwritten  offering and the managing  underwriter  shall advise the
          Company  in  writing  that,  in its  opinion,  the number of shares of
          Common  Stock  requested  by the  Investors  to be  included  in  such
          registration is likely to affect  materially and adversely the success
          of the  offering or the price that would be received for any shares of
          Common Stock offered in such offering, then,  notwithstanding anything
          in Section 4(a) to the contrary, the Company shall only be required to
          include in such registration, to the extent of the number of shares of
          Common  Stock  which the  Company  is so  advised  can be sold in such
          offering,  (i) first, the number of shares of Common Stock proposed to
          be included in such registration for the account of the Company and/or
          any  stockholders  of the Company (other than the Investors) that have
          exercised  demand   registration   rights,   in  accordance  with  the
          priorities,  if any,  then  existing  among the  Company  and/or  such
          stockholders of the Company with  registration  rights (other than the
          Investors),  and (ii) second,  the shares of Common Stock requested to
          be  included in such  registration  by all other  stockholders  of the
          Company who have piggyback  registration  rights  (including,  without
          limitation,  the  Investors),  pro rata among such other  stockholders
          (including,  without  limitation,  the  Investors) on the basis of the
          number of shares of Common  Stock  that each of them  requested  to be
          included in such registration.

               (c) In connection with any offering  involving an underwriting of
          shares,  the Company  shall not be required  under Section 4 hereof or
          otherwise to include the  Registrable  Shares of any Investor  therein
          unless  such  Investor   accepts  and  agrees  to  the  terms  of  the
          underwriting  as agreed upon between the Company and the  underwriters
          selected by the Company.

               5.  OBLIGATIONS OF THE COMPANY.  In connection with the Company's
          obligation  under  Section  3 and 4 hereof  to file  the  Registration
          Statement  with  the SEC and to use its  best  efforts  to  cause  the
          Registration Statement to become effective as soon as practicable, the
          Company shall, as expeditiously as reasonably possible:

               (a) Prepare and file with the SEC such amendments and supplements
          to the  Registration  Statement and the prospectus  used in connection
          therewith  as may be necessary  to comply with the  provisions  of the
          Securities  Act with  respect to the  disposition  of all  Registrable
          Shares covered by the Registration Statement;

               (b) Furnish to the selling  Investors  such number of copies of a
          prospectus, including a preliminary prospectus, in conformity with the
          requirements   of  the  Securities   Act,  and  such  other  documents
          (including, without limitation,  prospectus amendments and supplements
          as are prepared by the Company in accordance  with Section 5(a) above)
          as the selling Investors may reasonably request in order to facilitate
          the disposition of such selling Investors' Registrable Shares;

               (c) Notify the selling  Investors,  at any time when a prospectus
          relating to the  Registration  Statement  is required to be  delivered
          under the Securities Act, of the happening of any event as a result of
          which the  prospectus  included  in or  relating  to the  Registration
          Statement contains an untrue statement of a material fact or omits any
          fact necessary to make the  statements  therein not  misleading;  and,
          thereafter,  subject to the  provisions  of Section 11 hereof,  if the
          Company has delivered the certificate referred to therein, the Company
          will  promptly  prepare  (and,  when  completed,  give  notice to each
          selling  Investor) a supplement  or amendment  to such  prospectus  so
          that, as thereafter  delivered to the  purchasers of such  Registrable
          Shares,  such  prospectus  will not contain an untrue  statement  of a
          material  fact  or  omit to  state  any  fact  necessary  to make  the
          statements   therein   not   misleading;   provided   that  upon  such
          notification by the Company,  the selling  Investors will not offer or
          sell  Registrable  Shares  until the Company has  notified the selling
          Investors  that it has  prepared a  supplement  or  amendment  to such
          prospectus and delivered copies of such supplement or amendment to the
          selling  Investors (it being understood and agreed by the Company that
          the foregoing proviso shall in no way diminish or otherwise impair the
          Company's  obligation  to promptly  prepare a prospectus  amendment or
          supplement as above  provided in this Section 5(c) and deliver  copies
          of same as above provided in Section 5(b) hereof); and

               (d) Use commercially  reasonable  efforts to register and qualify
          the  Registrable  Shares covered by the  Registration  Statement under
          such other securities or Blue Sky laws of such  jurisdictions as shall
          be  reasonably  appropriate  in the  opinion  of the  Company  and the
          managing underwriters,  if any, provided that the Company shall not be
          required in connection  therewith or as a condition thereto to qualify
          to do business  or to file a general  consent to service of process in
          any  such  states  or   jurisdictions,   and  provided   further  that
          (notwithstanding  anything  in this  Agreement  to the  contrary  with
          respect to the bearing of expenses) if any  jurisdiction  in which any
          of such  Registrable  Shares  shall be  qualified  shall  require that
          expenses incurred in connection with the qualification  therein of any
          such Registrable  Shares be borne by the selling  Investors,  then the
          selling Investors shall, to the extent required by such  jurisdiction,
          pay their pro rata share of such qualification expenses.

               6. FURNISH INFORMATION.  It shall be a condition precedent to the
          obligations  of the  Company  to  take  any  action  pursuant  to this
          Agreement that the selling Investors shall furnish to the Company such
          information  regarding  them  and the  securities  held by them as the
          Company shall reasonably  request and as shall be required in order to
          effect any registration by the Company pursuant to this Agreement.

               7. EXPENSES OF REGISTRATION.  All expenses incurred in connection
          with the  registration  of the  Registrable  Shares  pursuant  to this
          Agreement  (excluding   underwriting,   brokerage  and  other  selling
          commissions  and   discounts),   including   without   limitation  all
          registration and qualification and filing fees, printing, and fees and
          disbursements  of  counsel  for the  Company,  shall  be  borne by the
          Company.

               8. DELAY OF REGISTRATION. The Investors shall not take any action
          to restrain,  enjoin or otherwise delay any registration as the result
          of  any   controversy   which   might   arise  with   respect  to  the
          interpretation or implementation of this Agreement.

               9. INDEMNIFICATION.


               (a) To the extent  permitted by law,  the Company will  indemnify
          and hold harmless each selling Investor,  any investment  banking firm
          acting as an underwriter for the selling Investors,  any broker/dealer
          acting  on  behalf  of any  selling  Investors  and each  officer  and
          director   of  such   selling   Investor,   such   underwriter,   such
          broker/dealer  and each  person,  if any,  who  controls  such selling
          Investor,  such underwriter or broker/dealer within the meaning of the
          Securities Act,  against any losses,  claims,  damages or liabilities,
          joint  or  several,  to  which  they  may  become  subject  under  the
          Securities Act or otherwise,  insofar as such losses,  claims, damages
          or  liabilities  (or actions in respect  thereof)  arise out of or are
          based upon any untrue or alleged untrue statement of any material fact
          contained in the Registration Statement, in any preliminary prospectus
          or  final  prospectus   relating  thereto  or  in  any  amendments  or
          supplements  to the  Registration  Statement  or any such  preliminary
          prospectus or final prospectus,  or arise out of or are based upon the
          omission or alleged omission to state therein a material fact required
          to be stated therein,  or necessary to make the statements therein not
          misleading;   and  will   reimburse   such  selling   Investor,   such
          underwriter,  broker/dealer  or such officer,  director or controlling
          person for any legal or other expenses  reasonably incurred by them in
          connection  with  investigating  or  defending  any such loss,  claim,
          damage,  liability or action;  provided,  however,  that the indemnity
          agreement  contained  in this  Section 9(a) shall not apply to amounts
          paid in  settlement  of any such loss,  claim,  damage,  liability  or
          action if such  settlement  is  effected  without  the  consent of the
          Company, nor shall the Company be liable in any such case for any such
          loss, damage,  liability or action to the extent that it arises out of
          or is based upon an untrue  statement or alleged  untrue  statement or
          omission  made in  connection  with the  Registration  Statement,  any
          preliminary  prospectus or final  prospectus  relating  thereto or any
          amendments or  supplements to the  Registration  Statement or any such
          preliminary  prospectus or final  prospectus,  in reliance upon and in
          conformity  with written  information  furnished  expressly for use in
          connection  with the  Registration  Statement or any such  preliminary
          prospectus  or  final  prospectus  by  the  selling   Investors,   any
          underwriter for them or controlling person with respect to them.

               (b) To the extent  permitted by law,  each selling  Investor will
          severally  and not jointly  indemnify  and hold  harmless the Company,
          each of its  directors,  each of its  officers  who  have  signed  the
          Registration Statement,  each person, if any, who controls the Company
          within the meaning of the Securities Act, any investment  banking firm
          acting as underwriter for the Company or the selling Investors, or any
          broker/dealer   acting  on  behalf  of  the  Company  or  any  selling
          Investors, and all other selling Investors against any losses, claims,
          damages or  liabilities  to which the  Company  or any such  director,
          officer,  controlling  person,  underwriter,  or broker/dealer or such
          other selling Investor may become subject to, under the Securities Act
          or otherwise,  insofar as such losses,  claims, damages or liabilities
          (or  actions  in respect  thereto)  arise out of or are based upon any
          untrue or alleged  untrue  statement of any material fact contained in
          the  Registration  Statement or any  preliminary  prospectus  or final
          prospectus,  relating  thereto or in any  amendments or supplements to
          the Registration Statement or any such preliminary prospectus or final
          prospectus,  or arise out of or are based upon the omission or alleged
          omission  to state  therein  a  material  fact  required  to be stated
          therein or necessary to make the statements therein not misleading, in
          each  case to the  extent  and only to the  extent  that  such  untrue
          statement or alleged untrue  statement or omission or alleged omission
          was made in the Registration  Statement, in any preliminary prospectus
          or  final  prospectus   relating  thereto  or  in  any  amendments  or
          supplements  to the  Registration  Statement  or any such  preliminary
          prospectus  or final  prospectus,  in reliance  upon and in conformity
          with written  information  furnished by the selling Investor expressly
          for  use  in  connection  with  the  Registration  Statement,  or  any
          preliminary prospectus or final prospectus;  and such selling Investor
          will reimburse any legal or other expenses  reasonably incurred by the
          Company   or  any  such   director,   officer,   controlling   person,
          underwriter,  broker/dealer  or other  selling  Investor in connection
          with  investigating  or  defending  any  such  loss,  claim,   damage,
          liability or action,  provided,  however,  that the  liability of each
          selling  Investor  hereunder  shall be limited to the proceeds (net of
          underwriting  discounts  and  commissions,  if any)  received  by such
          selling  Investor from the sale of  Registrable  Shares covered by the
          Registration  Statement,  and  provided,  further,  however,  that the
          indemnity  agreement contained in this Section 9(b) shall not apply to
          amounts paid in settlement of any such loss, claim, damage,  liability
          or action if such settlement is effected  without the consent of those
          selling  Investor(s)  against which the request for indemnity is being
          made.

               (c) Promptly  after  receipt by an  indemnified  party under this
          Section  9  of  notice  of  the  commencement  of  any  action,   such
          indemnified  party will,  if a claim in respect  thereof is to be made
          against  any  indemnifying  party  under this  Section  9,  notify the
          indemnifying  party in writing  of the  commencement  thereof  and the
          indemnifying  party shall have the right to participate in and, to the
          extent  the  indemnifying  party  desires,   jointly  with  any  other
          indemnifying  party  similarly  noticed,  to assume at its expense the
          defense thereof with counsel mutually satisfactory to the indemnifying
          parties with the consent of the  indemnified  party which consent will
          not be  unreasonably  withheld,  conditioned or delayed.  In the event
          that the indemnifying party assumes any such defense,  the indemnified
          party may  participate in such defense with its own counsel and at its
          own expense, provided,  however, that the counsel for the indemnifying
          party  shall act as lead  counsel in all  matters  pertaining  to such
          defense or settlement of such claim and the  indemnifying  party shall
          only pay for such indemnified party's expenses for the period prior to
          the date of such indemnifying  party's  participation in such defense.
          The  failure  to  notify  an   indemnifying   party  promptly  of  the
          commencement  of any such  action,  if  prejudicial  to his ability to
          defend such  action,  shall  relieve  such  indemnifying  party of any
          liability  to the  indemnified  party  under  this  Section 9, but the
          omission so to notify the  indemnifying  party will not relieve him of
          any liability  which he may have to any  indemnified  party  otherwise
          other than under this Section 9.

               (d)   Notwithstanding   anything  to  the  contrary  herein,  the
          indemnifying  party shall not be entitled to settle any claim, suit or
          proceeding  unless in connection  with such settlement the indemnified
          party  receives an  unconditional  release with respect to the subject
          matter of such claim,  suit or proceeding and such settlement does not
          contain any admission of fault by the indemnified party.

               10.  REPORTS  UNDER  THE  EXCHANGE  ACT.  With a view  to  making
          available to the Investors the benefits of Rule 144 and any other rule
          or  regulation of the SEC that may at any time permit the Investors to
          sell the  Purchased  Shares to the public  without  registration,  the
          Company agrees to use commercially reasonable efforts: (i) to make and
          keep public information  available,  as those terms are understood and
          defined in the General  Instructions  to Form S-3, or any successor or
          substitute  form,  and in Rule  144,  (ii) to file  with  the SEC in a
          timely manner all reports and other documents  required to be filed by
          an issuer of securities  registered  under the  Securities  Act or the
          Exchange Act, (iii) as long as any Investor owns any Purchased Shares,
          to furnish in writing upon such Investor's request a written statement
          by the Company that it has complied with the reporting requirements of
          Rule  144  and of the  Securities  Act and the  Exchange  Act,  and to
          furnish to such Investor a copy of the most recent annual or quarterly
          report of the Company,  and such other  reports and documents so filed
          by the  Company  as may  be  reasonably  requested  in  availing  such
          Investor of any rule or regulation of the SEC  permitting  the selling
          of any such Purchased  Shares without  registration and (iv) undertake
          any   additional   actions   reasonably   necessary  to  maintain  the
          availability of the Registration Statement or the use of Rule 144.

               11. DEFERRAL AND LOCK-UP.


               Notwithstanding  anything in this  Agreement to the contrary,  if
          the  Company  shall  furnish to the selling  Investors  a  certificate
          signed by the  President  or Chief  Executive  Officer of the  Company
          stating that, after  consultation  with counsel,  he has made the good
          faith determination (i) that continued use by the selling Investors of
          the  Registration  Statement for purposes of effecting offers or sales
          of  Registrable  Shares  pursuant  thereto  would  require,  under the
          Securities Act, premature disclosure in the Registration Statement (or
          the prospectus  relating thereto) of material,  nonpublic  information
          concerning  the  Company,  its  business or  prospects or any proposed
          material transaction  involving the Company,  (ii) that such premature
          disclosure would be materially adverse to the Company, its business or
          prospects or any such proposed material  transaction or would make the
          successful   consummation   by  the  Company  of  any  such   material
          transaction  significantly  less likely and (iii) that it is therefore
          essential  to suspend the use by the  Investors  of such  Registration
          Statement  (and the  prospectus  relating  thereto)  for  purposes  of
          effecting offers or sales of Registrable Shares pursuant thereto, then
          the right of the selling  Investors to use the Registration  Statement
          (and the prospectus relating thereto) for purposes of effecting offers
          or sales of Registrable Shares pursuant thereto shall be suspended for
          a period  (the  "Suspension  Period")  of not more than 90 days  after
          delivery by the Company of the  certificate  referred to above in this
          Section 11. During the Suspension Period,  none of the Investors shall
          offer or sell any  Registrable  Shares pursuant to or in reliance upon
          the Registration Statement (or the prospectus relating thereto).

               12.  TRANSFER OF REGISTRATION  RIGHTS.  None of the rights of any
          Investor under this Agreement  shall be transferred or assigned to any
          person  unless (i) such  person is a  Qualifying  Holder  (as  defined
          below),  and (ii) such  person  agrees to become a party to, and bound
          by,  all of the  terms  and  conditions  of,  this  Agreement  by duly
          executing and  delivering to the Company an Instrument of Adherence in
          the form  attached as Exhibit B hereto.  For  purposes of this Section
          12, the term  "Qualifying  Holder"  shall  mean,  with  respect to any
          Investor,  (i) any partner thereof, (ii) any corporation,  partnership
          controlling,  controlled  by,  or  under  common  control  with,  such
          Investor or any partner thereof,  or (iii) any other direct transferee
          from such Investor of at least 50% of those Registrable Shares held or
          that may be  acquired  by such  Investor.  None of the  rights  of any
          Investor under this Agreement  shall be transferred or assigned to any
          Person  (including,  without  limitation,  a  Qualifying  Holder) that
          acquires  Registrable  Shares in the event that and to the extent that
          such Person is eligible to resell such Registrable  Shares pursuant to
          Rule  144(k)  of  the  Securities  Act or may  otherwise  resell  such
          Registrable  Shares  pursuant to an  exemption  from the  registration
          provisions of the Securities Act.

               13. ENTIRE AGREEMENT. This Agreement constitutes and contains the
          entire agreement and  understanding of the parties with respect to the
          subject  matter  hereof,  and it also  supersedes  any  and all  prior
          negotiations,   correspondence,   agreements  or  understandings  with
          respect to the subject matter hereof.

               14. MISCELLANEOUS.


               (a) This  Agreement may not be amended,  modified or  terminated,
          and no rights or  provisions  may be waived,  except  with the written
          consent of the Majority Holders and the Company.

               (b)  This  Agreement  shall  be  governed  by and  construed  and
          enforced  in  accordance  with the laws of the State of New York,  and
          shall be binding  upon and inure to the benefit of the parties  hereto
          and their respective heirs,  personal  representatives,  successors or
          assigns,  provided that the terms and  conditions of Section 12 hereof
          are satisfied.  This Agreement shall also be binding upon and inure to
          the benefit of any transferee of any of the Purchased  Shares provided
          that the terms and  conditions  of Section  12 hereof  are  satisfied.
          Notwithstanding  anything in this Agreement to the contrary, if at any
          time any Investor shall cease to own any Purchased Shares, all of such
          Investor's rights under this Agreement shall immediately terminate.

               (c) (i) Any notices, reports or other correspondence (hereinafter
          collectively referred to as "correspondence") required or permitted to
          be given hereunder shall be sent by courier (overnight or same day) or
          telecopy or delivered by hand to the party to whom such correspondence
          is required or permitted to be given hereunder. The date of giving any
          notice shall be the date of its actual receipt.

               (ii) All  correspondence  to the Company  shall be  addressed  as
          follows:

                              Neurogen Corporation
                              35 Northeast Industrial Road
                              Branford, CT 06405
                              Attention: Harry H. Penner, Jr.
                              President and Chief Executive Officer
                              Telecopier: 203-481-8683

          with a copy to:

                              Milbank, Tweed, Hadley & McCloy LLP
                              1 Chase Manhattan Plaza
                              New York, NY 10005
                              Attention:  Donald B. Brant Jr.
                              Title: Partner
                              Telecopier:  212-530-5219

               (iii) All  correspondence  to any Investor  shall be sent to such
          Purchaser at the address set forth in Exhibit A.

               (d) Any entity may change the address to which  correspondence to
          it is to be addressed by notification as provided for herein.

               (e) The  parties  acknowledge  and agree that in the event of any
          breach of this Agreement,  remedies at law may be inadequate, and each
          of the parties  hereto shall be entitled to seek specific  performance
          of the  obligations of the other parties  hereto and such  appropriate
          injunctive   relief  as  may  be  granted  by  a  court  of  competent
          jurisdiction.

               (f) This  Agreement may be executed in a number of  counterparts,
          an of which together shall for all purposes  constitute one Agreement,
          binding  on all the  parties  hereto  notwithstanding  that  all  such
          parties have not signed the same counterpart.


<PAGE>



               IN  WITNESS  WHEREOF,  the  parties  hereto  have  executed  this
          Registration  Rights  Agreement  as of the date and year  first  above
          written.

                                    Neurogen Corporation

                                    By: /s/Harry H. Penner, Jr.
                                    --------------------------------------------
                                    Name: Harry H. Penner, Jr.
                                    Title: President and Chief Executive Officer





               THE INITIAL  INVESTOR'S  SIGNATURE TO THE INVESTOR  QUESTIONNAIRE
          DATED EVEN DATE  HEREWITH  SHALL  CONSTITUTE  THE  INITIAL  INVESTOR'S
          SIGNATURE TO THIS REGISTRATION RIGHTS AGREEMENT.


<PAGE>



                                    EXHIBIT A

                                Name and Address

Clarion Capital Corporation
ATT:  Thomas Niehaus
555 Westbury Avenue
Carl Place, NY  11514

Clarion Offshore Fund LTD.
ATT:  Thomas Niehaus
555 Westbury Avenue
Carl Place, NY  11514

Clarion Partners, L.P.
ATT:  Thomas Niehaus
555 Westbury Avenue
Carl Place, NY  11514

DWS Investments Gmbh
ATT:  Andreas Kraft
Gruneburgweg 113-115
60612 Frankfurt AM MAIN
Germany

Munder Framlington Healthcare
ATT:  Antony Milford
155 Bishops Gate
London, EC2M 3XJ

Jackson Square Partners, L.P.
ATT:  Will Weinstein
909 Montgomery Street
Suite 600
San Francisco, CA 94133

Marcuard Cook &CIEE, S.A.
7 Rue des Alpes
P.O. Box 1380
1211 General
Geneva Switzerland

Metzler Investments
ATT:  Klaus Hagedorn
Grosse Gallustrasse, 18
Frankfurt, Germany 60311

HCI Healthcare Investments Ltd.
c/o New Medical Technologies
ATT:  DR. Philipp Meckler
Elisabethenstrasse 23
CH-4051 Basel Switzerland

Oppenheimer & Co.
ATT:  Frank Jennings/George Evans
Two World Trade Center
New York, NY 10048

Veritas SG Investment Trust GMBH
ATT:   Ralf Von Ziegesar
Bettinastrasse, 62
Frankfurt, Germany 60325


<PAGE>


                                    EXHIBIT B

                             Instrument of Adherence

     Reference is hereby made to that  certain  Registration  Rights  Agreement,
dated as of  ______________  ___, 2000, among Neurogen  Corporation,  a Delaware
corporation (the "Company"),  the Initial  Investors and the Investor  Permitted
Transferees,  as  amended  and in effect  from  time to time (the  "Registration
Rights Agreement").  Capitalized terms used herein without definition shall have
the respective meanings ascribed thereto in the Registration Rights Agreement.

     The  undersigned,  in order to become the owner or holder of  [___________]
shares of common stock, par value $0.025 per share (the "Common Stock"),  of the
Company],  hereby agrees that,  from and after the date hereof,  the undersigned
has become a party to the  Registration  Rights  Agreement in the capacity of an
Investor Permitted Transferee, and is entitled to all of the benefits under, and
is subject to all of the obligations, restrictions and limitations set forth in,
the  Registration  Rights  Agreement that are  applicable to Investor  Permitted
Transferees.  This  Instrument of Adherence shall take effect and shall become a
part of the Registration Rights Agreement immediately upon execution.

     Executed  under  seal as of the  date set  forth  below  under  the laws of
_____________________.



                                            Signature:__________________________
                                                      Name:
                                                      Title:

Accepted:

Neurogen Corporation

By:___________________________________________
         Harry H. Penner, Jr.
         President and Chief Executive Officer


Date:_________________________________
































© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission