CORTEX PHARMACEUTICALS INC/DE/
S-8, 1996-09-13
PHARMACEUTICAL PREPARATIONS
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<PAGE>

   As Filed With the Securities and Exchange Commission on September 13, 1996
                                                  Registration No. 333-________
- -------------------------------------------------------------------------------



                       SECURITIES AND EXCHANGE COMMISSION
                             Washington. D.C. 20549

                                  -------------

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                                  -------------

                          CORTEX PHARMACEUTICALS, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)


                    Delaware                                33-0303583
  (STATE OR OTHER JURISDICTION OF INCORPORATION          (I.R.S. EMPLOYER
                OR ORGANIZATION)                        IDENTIFICATION NO.)


                15241 Barranca Parkway, Irvine, California 92718
               (ADDRESS OF PRINCIPAL EXECUTIVE OFFICES) (ZIP CODE)

                                  -------------

                     1989 SPECIAL NONQUALIFIED STOCK OPTION
                             AND STOCK PURCHASE PLAN
                            (FULL TITLE OF THE PLAN)

                                  -------------

          Vincent F. Simmon, Ph.D., President and Chief Executive Officer
                          Cortex Pharmaceuticals, Inc.
                15241 Barranca Parkway, Irvine, California 92718
                     (NAME AND ADDRESS OF AGENT FOR SERVICE)



                                 (714) 727-3157
          (TELEPHONE NUMBER, INCLUDING AREA CODE, OF AGENT FOR SERVICE)


                                    Copy to:
                             Lawrence B. Cohn, Esq.
          Stradling, Yocca, Carlson & Rauth, a Professional Corporation
      660 Newport Center Drive, Suite 1600, Newport Beach, California 92660



                       [cover page continued on next page]



<PAGE>

                             [cover page continued]



                         CALCULATION OF REGISTRATION FEE

- -------------------------------------------------------------------------------
                                                        Proposed
                                          Proposed      Maximum 
Title of Securities    Amount To Be        Maximum      Aggregate   Amount of
 To Be Registered    Registered (1)(2)    Offering      Offering   Registration
                                       Price Per Share  Price (3)      Fee
- -------------------------------------------------------------------------------
Common Stock, 
$.001 par value      100,000 shares      $2.78125       $278,125.00  $100.00
- -------------------------------------------------------------------------------

(1)  Includes additional shares of Common Stock that may become issuable 
     pursuant to the anti-dilution adjustment provisions of the Cortex 1989 
     Special Nonqualified Stock Option and Stock Purchase  Plan (the "Plan"). 

(2)  On January 11, 1995, the Company effected a one-for-five reverse split 
     of its authorized shares of Common Stock (the "Reverse Split").  On 
     October 11, 1991, the Company registered 80,000 shares of Common Stock 
     (or 400,000 shares of pre-Reverse Split Common Stock) available for 
     grant under the Plan on a Registration Statement on Form S-8 
     (Registration No. 33-43252), on January 28, 1994, the Company registered 
     an additional 80,000 shares of Common Stock (or 400,000 shares of 
     pre-Reverse Split Common Stock) available for grant under the Plan on a 
     Registration Statement on Form S-8 (Registration No. 33-74610) and on 
     February 13, 1995, the Company registered an additional 140,000 shares 
     of Common Stock available for grant under the Plan on Form S-8 
     (Registration No. 33-89412).
     
(3)  The aggregate offering price for 100,000 shares of Common Stock 
     registered hereby, which are to be offered to the registrant's employees 
     pursuant to the Plan, is estimated solely for the purpose of calculating 
     the registration fee, in accordance with Rule 457(h)(1), on the basis of 
     the price of securities of the same class as determined in accordance 
     with Rule 457(c), using the average of the closing bid and asked price 
     of the Common Stock of the Registrant on the NASDAQ System on 
     September 9, 1996.
     

<PAGE>

                                     PART II
               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE.

     The contents of the registrant's Registration Statements on Form 
S-8 (Registration No. 33-43252,  Registration No. 33-74610, and 
Registration No. 33-89412) are incorporated herein by reference.


ITEM 8.  EXHIBITS.

     The following exhibits are filed as part of this Registration Statement:

     Number                           Description
     ------                           -----------

     4.10 Amendment to 1989 Special Nonqualified Stock Option and Stock 
          Purchase Plan adopted December 12, 1995

     5    Opinion of Stradling, Yocca, Carlson & Rauth, a Professional 
          Corporation, Counsel to the Registrant

     23.1 Consent of Stradling, Yocca, Carlson & Rauth, a Professional 
          Corporation (included in the Opinion filed as Exhibit 5)

     23.2 Consent of Ernst & Young LLP, Independent Auditors, re:  
          Financial Statements of Cortex Pharmaceuticals, Inc.


                                       2

<PAGE>

                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the 
registrant certifies that it has reasonable grounds to believe that it meets 
all of the requirements for filing on Form S-8 and has duly caused this 
registration statement to be signed on its behalf by the undersigned, 
thereunto duly authorized, in the City of Irvine, State of California, on the 
13th day of September, 1996.
 
                                          CORTEX PHARMACEUTICALS, INC.



                                     By:  /s/ Vincent F. Simmon, Ph.D.
                                          -----------------------------------
                                          Vincent F. Simmon, Ph.D.
                                          President, Chief Executive Officer
                                            and Director
                                          (Principal Executive Officer)

     Pursuant to the requirements of the Securities Act of 1933, this 
registration statement has been signed by the following persons in the 
capacities and on the date indicated.

        Signature                           Title                    Date
        ---------                           -----                    ----
/s/ Vincent F. Simmon, Ph.D.       President, Chief           September 13, 1996
- -------------------------------    Executive Officer and
   Vincent F. Simmon, Ph.D.        Director


   /s/ D. Scott Hagen              Chief Financial Officer    September 13, 1996
- -------------------------------    and Chief Operating       
    D. Scott Hagen                 Officer (Principal        
                                   Financial and Accounting  
                                   Officer)                  


  /s/ Harvey S. Sadow, Ph.D.       Chairman of the Board      September 13, 1996
- -------------------------------    and Director 
   Harvey S. Sadow, Ph.D.       


  /s/ Carl W. Cotman, Ph.D.        Director                   September 13, 1996
- -------------------------------
   Carl W. Cotman, Ph.D.


 /s/ Jerome M. Arnold, Ph.D.       Director                   September 13, 1996
- -------------------------------
  Jerome M. Arnold, Ph.D.


/s/ Davis L. Temple, Jr., Ph.D.    Director                   September 13, 1996
- -------------------------------
  Davis L. Temple, Jr., Ph.D.


                                      S-1


<PAGE>


                                    Director                  September 13, 1996
- --------------------------
      Michael G. Grey


  /s/ Robert F. Allnutt             Director                  September 13, 1996
- --------------------------
    Robert F. Allnutt


                                      S-2




<PAGE>

                                                              EXHIBIT 4.10



                                  AMENDMENT TO
                          CORTEX PHARMACEUTICALS, INC.
                            1989 SPECIAL NONQUALIFIED
                      STOCK OPTION AND STOCK PURCHASE PLAN



     Section 2 has been amended as of December 12, 1995, to read as follows:

          2.   SHARES SUBJECT TO THE SPECIAL PLAN.

               The shares of stock subject to the nonqualified options or rights
     to purchase having the terms and conditions set forth in Section 6 below
     (hereinafter "nonqualified options" and "rights of purchase") and other
     provisions of the Special Plan shall be shares of the Company's authorized
     but unissued or reacquired common stock (herein sometimes referred to as
     the "Common Stock").  The total number of shares of the Common Stock of the
     Company which may be issued under the Special Plan shall be determined from
     time to time by resolution of the Board of Directors of the Company, but
     shall not exceed, in aggregate, four hundred thousand shares.  In the event
     that any outstanding nonqualified option or right of purchase granted under
     the Special Plan can no longer under any circumstances be exercised, or in
     the event that any shares purchased pursuant to the Special Plan are
     reacquired by the Company, for any reason, the shares of Common Stock
     allocable to the unexercised portion of such nonqualified option or right
     of purchase, or the shares reacquired, as the case may be, shall again be
     subject to grant or issuance under the Special Plan.





<PAGE>


                                                                 EXHIBIT 5


                                     [LETTERHEAD]


                                   September 5, 1996


Cortex Pharmaceuticals, Inc.
15241 Barranca Parkway
Irvine, California 92718


          RE:  REGISTRATION STATEMENT ON FORM S-8--1989 SPECIAL NONQUALIFIED
               STOCK OPTION AND STOCK PURCHASE PLAN

Gentlemen:

          At your request, we have examined the form of Registration Statement
on Form S-8 (the "Registration Statement") being filed by Cortex
Pharmaceuticals, Inc., a Delaware corporation (the "Company"), with the
Securities and Exchange Commission in connection with the registration under the
Securities Act of 1933, as amended, of an aggregate of 100,000 shares of the
Company's common stock, $.001 par value ("Common Stock"), issuable under the
Company's 1989 Special Nonqualified Stock Option and Stock Purchase Plan (the
"Plan").

          We have examined the proceedings heretofore taken and are familiar
with the additional proceedings proposed to be taken by the Company in
connection with the authorization, issuance and sale of the securities referred
to above.

          It is our opinion:

               1.   That stock options and stock-purchase rights, when issued in
accordance with the Plan, will be legally issued and binding obligations of the
Company.

               2.   That 100,000 shares of Common Stock, when issued under the
Plan and against full payment in accordance with the respective terms and
conditions of the Plan, will be legally and validly issued, fully paid and
nonassessable.



<PAGE>

Cortex Pharmaceuticals, Inc.
September 5, 1996
Page 2


          We consent to the use of this opinion as an Exhibit to the
Registration Statement. 


                              Very truly yours,

                              /s/ STRADLING, YOCCA, CARLSON & RAUTH

                              STRADLING, YOCCA, CARLSON & RAUTH
                              a professional corporation 




<PAGE>
                                                              EXHIBIT 23.2

           CONSENT OF ERNEST & YOUNG LLP, INDEPENDENT AUDITORS

We consent to the incorporation by reference in the Registration Statements 
(Form S-8 Nos. 33-43252; 33-74610 and 33-89412) pertaining to 1989 Special 
Nonqualified Stock Option and Stock Purchase Plan of our report dated July 
18, 1996, with respect to the financial statements of Cortex Pharmaceuticals, 
Inc. included in the Annual Report (Form 10-KSB) for the year ended June 30, 
1995.

                                          /s/ Ernest & Young LLP
                                          ----------------------
                                          ERNEST & YOUNG LLP


San Diego, California
September 9, 1996








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