CORTEX PHARMACEUTICALS INC/DE/
S-8, 1999-07-08
PHARMACEUTICAL PREPARATIONS
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<PAGE>

     As Filed With the Securities and Exchange Commission on July 8, 1999
                                              Registration No. 333-
- --------------------------------------------------------------------------------

                      SECURITIES AND EXCHANGE COMMISSION
                            Washington. D.C. 20549
                             --------------------

                                   FORM S-8
                            REGISTRATION STATEMENT
                                     Under
                          THE SECURITIES ACT OF 1933

                             --------------------

                          CORTEX PHARMACEUTICALS, INC.
             (Exact name of registrant as specified in its charter)


           Delaware                                      33-0303583
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
 incorporation or organization)


               15241 Barranca Parkway, Irvine, California  92618
                    (Address of Principal Executive Offices)

                           -------------------------

                           1996 STOCK INCENTIVE PLAN
                            (Full title of the plan)

                            ------------------------

                           Vincent F. Simmon, Ph.D.
                     President and Chief Executive Officer
                         Cortex Pharmaceuticals, Inc.
                            15241 Barranca Parkway
                           Irvine, California  92618
                    (Name and address of agent for service)

                                (949) 727-3157
         (Telephone number, including area code, of agent for service)

                                   Copy to:
                            Lawrence B. Cohn, Esq.
          Stradling Yocca Carlson & Rauth, a Professional Corporation
     660 Newport Center Drive, Suite 1600, Newport Beach, California 92660


                        CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------------
    Title of                              Proposed Maximum        Proposed Maximum
   Securities          Amount To Be      Offering Price Per      Aggregate Offering        Amount Of
 To Be Registered       Registered           Share (1)               Price (1)          Registration Fee
<S>                    <C>               <C>                     <C>                    <C>
- -----------------------------------------------------------------------------------------------------------------
Common Stock,              1,056,451          $0.93                  $982,499               $273
$.001  par value            shares
- -----------------------------------------------------------------------------------------------------------------
</TABLE>

(1)  Estimated solely for the purpose of calculating the registration fee, in
     accordance with Rule 457(h)(1), on the basis of the price of securities of
     the same class, as determined in accordance with Rule 457(c), using the
     average of the high and low bids reported on the system of the National
     Association of Securities Dealers, Inc., known as the OTC Bulletin Board,
     for the Common Stock on July 2, 1999, which was $0.93 per share.
<PAGE>

                                    PART II
              INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

  This registration statement relates to the Cortex Pharmaceuticals, Inc. (the
"Company") 1996 Stock Incentive Plan (the "Plan").  The Plan provides for an
automatic increase in the number of shares which may be issued under the Plan
effective on the last day of each fiscal year (June 30).  Such increase is equal
to twenty percent (20%) of the increase in the number of shares of Common Stock
outstanding since the last day of the previous fiscal year.  Based on an
increase in the Company's Common Stock outstanding of 5,282,256 shares since
June 30, 1998, the Plan is being amended to make available for grant an
additional 1,056,451 shares of Common Stock.  Initially, an aggregate of
2,402,319 shares of Common Stock were available for grant or award under the
Plan, and such 2,402,319 shares were registered on this form on January 31,
1997.  This registration statement covers the current increase of 1,056,451
shares of Common Stock issuable under the Plan, bringing the total number of
authorized shares to 3,458,770.

Item 3.  Incorporation of Documents by Reference.
         ---------------------------------------

         The following document is incorporated herein by reference:

         (a)    The contents of the Registrant's Registration Statement on Form
                S-8 (Registration No. 333-20777).

Item 8.  Exhibits.
         --------

          5.1   Opinion of Stradling Yocca Carlson & Rauth, a Professional
                Corporation.

          23.1  Consent of Stradling Yocca Carlson & Rauth, a Professional
                Corporation (included in the Opinion filed as Exhibit 5.1).

          23.2  Consent of Ernst and Young LLP, independent auditors.

          24.1  Power of Attorney (incorporated by reference to Exhibit 24.1 of
                the Company's Registration Statement on Form S-8 filed January
                31, 1997).
<PAGE>

                                 SIGNATURES

  Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Irvine, State of California, on the 7th day of July,
1999.


                              CORTEX PHARMACEUTICALS, INC.


                              By:   /s/ Vincent F. Simmon, Ph.D.
                                    -----------------------------
                                    Vincent F. Simmon, Ph.D.
                                    Chief Executive Officer


                               POWER OF ATTORNEY

     Pursuant to the requirements of the Securities Act of 1933, as amended,
this registration statement has been signed by the following persons in the
capacities and on the dates indicated.

<TABLE>
<CAPTION>
             Signature                        Title                         Date
             ---------                        -----                         ----
<S>                                 <C>                                  <C>
 /s/   Vincent F. Simmon, Ph.D.
- ---------------------------------   President, Chief Executive           July 7, 1999
  Vincent F. Simmon, Ph.D.          Officer (principal executive
                                    officer), Acting Chief Financial
                                    Officer (principal financial and
                                    accounting officer), Corporate
                                    Secretary and Director

/s/ Robert F. Allnutt *             Director                             July 7, 1999
- ------------------------------
  Robert F. Allnutt

/s/ Carl W. Cotman, Ph.D. *
- ------------------------------      Director                             July 7, 1999
  Carl W. Cotman, Ph.D.

/s/ Michael G. Grey *
- ------------------------------      Director                             July 7, 1999
  Michael G. Grey

/s/ Davis L. Temple, Jr., Ph.D. *   Director                             July 7, 1999
- ------------------------------
Davis L. Temple, Jr., Ph.D.


     *By: /s/ Vincent F. Simmon, Ph.D.
          ----------------------------
            Vincent F. Simmon, Ph.D.,
              as Attorney-In-Fact
</TABLE>
<PAGE>

                                 EXHIBIT INDEX

Exhibit
Number                                Description
- -------                               -----------
  5.1          Opinion of Stradling Yocca Carlson & Rauth, a Professional
               Corporation.

  23.1         Consent of Stradling Yocca Carlson & Rauth, a Professional
               Corporation (included in the Opinion filed as Exhibit 5.1).

  23.2         Consent of Ernst and Young LLP, independent auditors.

  24.1         Power of Attorney (incorporated by reference to Exhibit 24.1 of
               the Company's Registration Statement on Form S-8 filed January
               31, 1997).

<PAGE>

<TABLE>
<S>                                                                     <C>
                        STRADLING YOCCA CARLSON & RAUTH
                          A PROFESSIONAL CORPORATION                     SAN FRANCISCO OFFICE
                               ATTORNEYS AT LAW                         44 MONTGOMERY STREET,
                     660 NEWPORT CENTER DRIVE, SUITE 1600                     SUITE 2950
                     NEWPORT BEACH, CALIFORNIA 92660-6441          SAN FRANCISCO, CALIFORNIA 94104
                           TELEPHONE (949) 725-4000                        TELEPHONE  (415) 765-9180
                           FACSIMILE (949) 725-4100                        FACSIMILE  (415) 765-9187

</TABLE>


                                 July 8, 1999


Cortex Pharmaceuticals, Inc.
15241 Barranca Parkway
Irvine, California  92618

          Re:      Registration Statement on Form S-8

Gentlemen:

     At your request, we have examined the form of Registration Statement on
Form S-8 (the "Registration Statement") being filed by Cortex Pharmaceuticals,
Inc., a Delaware corporation (the "Company"), with the Securities and Exchange
Commission in connection with the registration under the Securities Act of 1933,
as amended, of an additional 1,056,451 shares of the Company's common stock,
$.001 par value ("Common Stock"), issuable under the Company's 1996 Stock
Incentive Plan (the "Plan").

     We have examined the proceedings heretofore taken and are familiar with the
additional proceedings proposed to be taken by the Company in connection with
the authorization, issuance and sale of the securities referred to above.

     Based on the foregoing, it is our opinion that the 1,056,451 shares of
Common Stock to be issued under the Plan against full payment in accordance with
the respective terms and conditions of the Plan will be legally and validly
issued, fully paid and nonassessable.

     We consent to the use of this opinion as an exhibit to the Registration
Statement.

                                 Very truly yours,


                                 /s/ STRADLING YOCCA CARLSON & RAUTH

<PAGE>

                                                                    EXHIBIT 23.2


              CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

     We consent to the incorporation by reference in the Registration Statement
(Form S-8) pertaining to the 1996 Stock Incentive Plan of Cortex
Pharmaceuticals, Inc. of our report dated July 17, 1998 with respect to the
financial statements of Cortex Pharmaceuticals, Inc. included in its Annual
Report (Form 10-KSB) for the year ended June 30, 1998, filed with the Securities
and Exchange Commission.

                                             /s/ Ernst & Young LLP
                                             ERNST & YOUNG LLP

San Diego, California
July 6, 1999



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