ROBERTS PHARMACEUTICAL CORP
SC 13D, 1999-08-04
PHARMACEUTICAL PREPARATIONS
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                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

                                 SCHEDULE 13D
                                (Rule 13d-101)

            INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
           TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO
                                 RULE 13d-2(a)


                       ROBERTS PHARMACEUTICAL CORPORATION
- --------------------------------------------------------------------------------
                                (Name of Issuer)


                          Common Stock, par value $.01
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                   77049110
- --------------------------------------------------------------------------------
                                 (CUSIP Number)


                    William A. Nuerge, Shire Richwood Inc.,
        7900 Tanners Gate Drive, Florence, Kentucky 41042 (606) 282-2100
- --------------------------------------------------------------------------------
                 (Name, Address and Telephone Number of Person
               Authorized to Receive Notices and Communications)


                                 July 26, 1999
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of This Statement)

     If the filing  person has  previously  filed a statement on Schedule 13G to
report the  acquisition  that is the subject of this Schedule 13D, and is filing
this  schedule  because  of Rule  13d-1(e),  13d-1(f)  or  13d-1(g),  check  the
following box [_].


          Note:  Schedules filed in paper format shall include a signed original
     and five copies of the schedule,  including all exhibits. See Rule 13d-7(b)
     for other parties to whom copies are to be sent.

                         (Continued on following pages)
                              (Page 1 of 8 Pages)

- ----------
(1)  The  remainder  of this  cover  page  shall be filled  out for a  reporting
     person's  initial  filing on this form with respect to the subject class of
     securities,  and for any subsequent amendment containing  information which
     would alter disclosures provided in a prior cover page.

     The  information  required on the remainder of this cover page shall not be
deemed to be "filed"  for the purpose of Section 18 of the  Securities  Exchange
Act of 1934 or otherwise  subject to the  liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


<PAGE>

CUSIP No.                              13D                   Page 2 of 8 Pages


________________________________________________________________________________
1    NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


        Shire Pharmaceuticals Group plc; I.R.S. Identification No.: N/A
________________________________________________________________________________
2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [_]
________________________________________________________________________________
3    SEC USE ONLY


________________________________________________________________________________
4    SOURCE OF FUNDS*


          WC
________________________________________________________________________________
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
     PURSUANT TO ITEMS 2(d) OR 2(e)                                   [_]


________________________________________________________________________________
6    CITIZENSHIP OR PLACE OF ORGANIZATION

                               England and Wales
________________________________________________________________________________
               7    SOLE VOTING POWER

  NUMBER OF
                                   6,345,926*
   SHARES      _________________________________________________________________
               8    SHARED VOTING POWER
BENEFICIALLY
  OWNED BY
               _________________________________________________________________
    EACH       9    SOLE DISPOSITIVE POWER

  REPORTING
                                   6,345,926*
   PERSON      _________________________________________________________________
               10   SHARED DISPOSITIVE POWER
    WITH

________________________________________________________________________________
11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                   6,345,926*
________________________________________________________________________________
12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [_]
________________________________________________________________________________
13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                                     19.9%
________________________________________________________________________________
14   TYPE OF REPORTING PERSON*

                                       CO
________________________________________________________________________________
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!

*    The shares of common stock, par value $.01 ("Roberts Shares"), of Roberts
     Pharmaceutical Corporation ("Roberts") covered by this item are purchasable
     by Shire Pharmaceuticals Group plc ("Shire") upon exercise of an option
     granted to Shire on July 26, 1999, and described in Item 4 of this
     Statement. Prior to the exercise of the option, Shire is not entitled to
     any rights as shareholder of Roberts, as to the Roberts Shares covered by
     the option. The option may only be exercised upon the happening of certain
     events referred to in Item 4, none of which has occurred as of this date.
     If the option were exercised, Shire would have the sole right to vote or
     dispose of the Roberts Shares issued as a result of such exercise.

                               Page 2 of 8 Pages
<PAGE>

Item 1.  Security and Issuer.

     This  Statement  on Schedule 13D (this  "Statement")  relates to the common
stock,  par value $.01  ("Roberts  Common  Stock"),  of  Roberts  Pharmaceutical
Corporation,  a New Jersey  corporation  ("Roberts").  The  principal  executive
offices of Roberts  are located at Meridian  Center II, 4  Industrial  Way West,
Eatontown, New Jersey 07724.

Item 2.  Identity and Background.

     This Statement is being filed by Shire Pharmaceuticals Group plc ("Shire"),
a public  limited  company  organized  under the laws of England and Wales.  The
principal business address of Shire is East Anton, Andover,  Hampshire SP10 5RG,
England. Shire is a pharmaceutical company.

     (a)-(c);  (f) The name, business address,  present principal  occupation or
employment,  and the name and  principal  business of any  corporation  or other
organization  in which such employment is conducted of each of the directors and
executive  officers  of Shire is set  forth in  Schedule  I  hereto.  Except  as
otherwise  indicated in Schedule I, each person listed in Schedule I hereto is a
citizen of the United Kingdom.

     (d)-(e) During the last five years,  neither Shire nor, to the knowledge of
Shire,  any of the persons listed on Schedule I hereto (i) has been convicted in
a criminal proceeding  (excluding traffic violations or similar misdemeanors) or
(ii) has been a party to a civil proceeding of a judicial or administrative body
of competent  jurisdiction  and as a result of such proceeding was or is subject
to a  judgment,  decree  or final  order  enjoining  future  violations  of,  or
prohibiting or mandating activities subject to, federal or state securities laws
or finding any violation with respect to such laws.

Item 3.  Source and Amount of Funds or Other Consideration.

     As more  fully  described  in Item 4 below,  pursuant  to the  terms of the
Option  Agreement  (as  defined  below),  Shire  will have the  right,  upon the
occurrence  of certain  events  specified  therein,  to purchase up to 6,345,926
shares of Roberts Common Stock at a price per share in cash equal to $30.00.  If
Shire  purchases  Roberts Common Stock pursuant to the Option  Agreement,  Shire
anticipates  that the funds to finance such purchase would come from its working
capital and funds available for investment.

Item 4.  Purpose of Transaction.

     On July 26,  1999,  Roberts,  Shire and Ruby  Acquisition  Sub Inc.,  a New
Jersey  corporation and wholly owned  subsidiary of Shire  ("Acquisition  Sub"),
entered  into an  Agreement  and Plan of Merger (the  "Merger  Agreement").  The
Merger Agreement provides, among other things, for the merger of Acquisition Sub
with and into  Roberts  (the  "Merger"),  with  Roberts  being  the  corporation
surviving the Merger.

                               Page 3 of 8 Pages
<PAGE>


     Pursuant to the Merger Agreement,  at the Effective Time (as defined in the
Merger Agreement), (i) each share of Roberts Common Stock issued and outstanding
immediately  prior to the Effective  Time (except for shares,  if any,  owned by
Roberts  or owned by any  subsidiary  of Roberts or owned by Shire or any of its
subsidiaries)  shall be  converted  into the right to  receive  either  ordinary
shares,  nominal value 5p of Shire  ("Ordinary  Shares") or American  Depositary
Shares,  each representing  three Ordinary Shares ("Shire ADS"); (ii) each share
of common stock of Acquisition Sub issued and outstanding  immediately  prior to
the  Effective  Time shall be canceled;  and (iii) each share of Roberts  Common
Stock that is owned by Roberts or owned by any subsidiary of Roberts or owned by
Shire or any of its  subsidiaries  shall be  canceled  and  retired and shall to
cease to exist.  For each share of Roberts Common Stock,  Roberts'  shareholders
will receive (i) a fixed exchange ratio of 3.4122 Ordinary Shares if the average
closing  price of Shire's  ADSs for the 15  consecutive  trading days ending the
third trading day prior to closing is between $23.73 and $29.01; (ii) a floating
exchange ratio between 3.4122 and 3.1280 if the average closing price is between
$29.01 and $31.65  (equivalent  to $33.00 per Roberts  share);  (iii) a floating
exchange ratio between 3.8407 and 3.4122 if the average closing price is between
$21.09  and  $23.73  (equivalent  to $27.00  per  Roberts  share);  (iv) a fixed
exchange ratio of 3.8407 if the average closing price is below $21.09; and (v) a
fixed  exchange  ratio of 3.1280 if the average  closing  price is greater  than
$31.65. At the Effective Time,  Roberts will become a wholly owned subsidiary of
Shire.

     Consummation  of the Merger is subject to the  satisfaction or waiver at or
prior to the Effective Time of certain  conditions,  including,  but not limited
to, (i) approval of the Merger  Agreement by the  shareholders of Roberts and by
the shareholders of Shire and (ii) various regulatory conditions.

     Pursuant to the Merger Agreement,  (i) the certificate of incorporation and
the by-laws of Roberts as in effect immediately prior to the Effective Time will
be the  certificate of  incorporation  and by-laws of Roberts as the corporation
surviving the Merger and (ii) the directors of Acquisition  Sub and the officers
of  Roberts,  in each  case at the  Effective  Time  will,  from and  after  the
Effective  Time,  be the  directors  and officers of Roberts as the  corporation
surviving the Merger until their successors have been duly elected and qualified
in accordance  with the certificate of  incorporation  and by-laws of Roberts as
the surviving corporation.

     The Merger Agreement contains certain customary restrictions on the conduct
of the  businesses  of Roberts and Shire pending the Merger,  including  certain
customary  restrictions relating to the capital stock of each. Roberts and Shire
have agreed in the Merger  Agreement that after the date of the Merger Agreement
and prior to the  Effective  Time they  will not  declare,  set aside or pay any
dividend  payable in cash,  stock or property in respect of any of their capital
stock.

     The Merger  Agreement is attached  hereto as Exhibit 1 and is  incorporated
herein by  reference  in its  entirety.  The  foregoing  summary  of the  Merger
Agreement  does not purport to be complete  and is  qualified in its entirety by
reference to such exhibit.

                               Page 4 of 8 Pages
<PAGE>


     Concurrent  with the execution of the Merger  Agreement,  Roberts and Shire
entered into an Option  Agreement (the "Option  Agreement"),  a copy of which is
attached hereto as Exhibit 2 and is incorporated  herein by reference.  Pursuant
to the Option  Agreement,  Roberts  granted  Shire an  irrevocable  option  (the
"Option")  to purchase,  subject to the terms  thereof,  up to 6,345,926  shares
("Option Shares") of Roberts Common Stock, at a price per share in cash equal to
$30.00 (the "Option Price").

     The Option Agreement  provides that Shire may exercise the Option, in whole
or in part, by delivering a written notice thereof (in accordance with the terms
of the Option  Agreement) at any time following the occurrence of any event that
entitles  Shire to receive a payment from  Roberts of $30 million (the  "Roberts
Termination  Amount") payable pursuant to the Merger Agreement until termination
of the Option Agreement.

     The Option  Agreement  will terminate upon the earlier of (i) the Effective
Time or (ii)  termination of the Merger  Agreement in accordance  with its terms
unless  Shire is entitled to receive  the Roberts  Termination  Amount (in which
case the Option  Agreement  will terminate one business day after Shire receives
the Roberts Termination Amount or the Roberts Termination Amount could no longer
be payable pursuant to the terms of the Merger Agreement).

     The Option Agreement provides that,  notwithstanding any other provision of
the Option  Agreement,  in no event will Shire's Total Profit (as defined below)
exceed in the  aggregate  $32 million,  and, if it  otherwise  would exceed such
amount,  Shire in its sole  discretion,  will  either  (i)  reduce the number of
shares of Roberts Common Stock subject to the Option,  (ii) pay cash to Roberts,
(iii) reduce the Roberts Termination Amount, or (iv) any combination thereof, so
that Shire's actually  realized Total Profit does not exceed $32.0 million after
taking into account the foregoing actions. For purposes of the Option Agreement,
"Total Profit" means the sum of the following: (i) (x) the amount (before taxes)
received  by Shire  pursuant to the sale of the shares of Roberts  Common  Stock
less (y) the exercise  price for such shares of Roberts  Common Stock,  (ii) any
amounts  (before  taxes)  received by Shire on the transfer of the option to any
unaffiliated persons or to Roberts and (iii) the Roberts Termination Amount.

     The  Option  Agreement  also  provides  that,   notwithstanding  any  other
provision  of the  Option  Agreement  to the  contrary,  the  Option  may not be
exercised  for a number of shares of Roberts  Common  Stock as would,  as of the
date the  Exercise  Notice is given,  result in a Notional  Total Profit of more
than $32.0  million.  For purposes of the Option  Agreement,  the term "Notional
Total Profit" with respect to any number of shares of Roberts Common Stock as to
which  Shire may  propose  to  exercise  the  Option  shall be the Total  Profit
determined as of the date the Exercise  Notice is given assuming that the Option
were  exercised  on such date for such number of shares of Roberts  Common Stock
and assuming that such shares of Roberts  Common Stock were sold for cash at the
closing  market price for the shares of Roberts  Common Stock as of the close of
business on the preceding trading day (less customary brokerage commissions).

                               Page 5 of 8 Pages
<PAGE>


     The foregoing  summary of the Stock Option Agreement does not purport to be
complete  and is qualified in its entirety by reference to the text of the Stock
Option Agreement attached as Exhibit 2 hereto.

Item 5.  Interest in Securities of the Issuer.

     (a)-(b) By reason of its  execution of the Option  Agreement,  Shire may be
deemed to have  beneficial  ownership of and sole voting and  dispositive  power
with respect to the shares of Roberts  Common  Stock  subject to the Option and,
accordingly,  may be deemed to  beneficially  own  6,345,926  shares of  Roberts
Common Stock as a result of the Option Agreement.  Based on the number of shares
of Roberts  Common Stock  subject to the Option,  Shire would  beneficially  own
approximately  19.9% of the  outstanding  Roberts  Common  Stock (based upon the
31,889,077  shares of Roberts  Common Stock  outstanding  on July 21,  1999,  as
represented to Shire by Roberts in the Merger Agreement)  following  exercise of
the  Option  for  6,345,926  shares of  Roberts  Common  Stock.  However,  Shire
expressly disclaims any beneficial  ownership of the 6,345,926 shares of Roberts
Common Stock which are obtainable by Shire upon exercise of the Option,  because
the Option is exercisable only in the  circumstances  set forth in Item 4 above,
none of which has occurred as of the date hereof.

     Neither Shire nor, to the best of Shire's knowledge, any of the individuals
named in Schedule I hereto, unless otherwise indicated therein, owns any Roberts
Common Stock.

     (c)  Neither  Shire  nor,  to the  best of  Shire's  knowledge,  any of the
individuals named in Schedule I hereto,  has effected any transaction in Roberts
Common Stock during the past 60 days.

     (d) So long as Shire has not purchased  Roberts Common Stock subject to the
Option,  Shire  does not have the right to  receive  or the power to direct  the
receipt  of  dividends  from,  or the  proceeds  from the sale of, any shares of
Roberts Common Stock.

     (e) Not applicable.

Item 6.  Contracts, Arrangements, Understandings or Relationships with Respect
         to Securities of the Issuer.

     Except as provided in the Merger Agreement,  the Option Agreement or as set
forth below,  neither  Shire nor, to the best of Shire's  knowledge,  any of the
individuals  named  in  Schedule  I  hereto,  has any  contracts,  arrangements,
understandings  or  relationships  (legal or  otherwise)  with any  person  with
respect to any securities of Roberts, including, but not limited to, transfer or
voting of any of the securities,  finder's fees, joint ventures,  loan or option
arrangements,  puts or calls,  guarantees  of  profits,  division  of profits or
losses, or the giving or withholding of proxies.

                               Page 6 of 8 Pages
<PAGE>


     Shire  entered into (i) a shareholder  agreement  dated as of July 26, 1999
(the  "Yamanouchi  Shareholder  Agreement")  with Yamanouchi Group Holdings Inc.
("Yamanouchi"),  the owner of  5,048,500  shares of  Roberts  Common  Stock (the
"Yamanouchi Shares") and (ii) a shareholder  agreement dated as of July 26, 1999
(the "Vukovich Shareholder Agreement") with Robert A. Vukovich ("Vukovich"), the
owner of  1,733,671  shares of Roberts  Common  Stock (the  "Vukovich  Shares").
Pursuant to the Yamanouchi  Shareholder  Agreement and the Vukovich  Shareholder
Agreement,  each of  Yamanouchi  and Vukovich has agreed to vote the  Yamanouchi
Shares and the Vukovich Shares,  respectively,  for the approval and adoption of
the Merger  Agreement  and any actions  required to be approved by  shareholders
related  thereto and against any proposal or transaction  which could prevent or
delay the consummation of the Merger Agreement.

Item 7.  Material to be Filed as Exhibits.

         Exhibit 1--    Agreement and Plan of Merger, dated as of July 26, 1999,
                        among   Roberts   Pharmaceutical    Corporation,   Shire
                        Pharmaceuticals Group plc and Ruby Acquisition Sub.

         Exhibit 2--    Option   Agreement,   dated as of July 26, 1999, between
                        Roberts    Pharmaceutical      Corporation   and   Shire
                        Pharmaceuticals Group plc.



                               Page 7 of 8 Pages
<PAGE>

                                   SIGNATURE


     After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.


                                                  August 4, 1999
                                        ----------------------------------------
                                                         (Date)


                                             SHIRE PHARMACEUTICALS GROUP plc

                                        ----------------------------------------
                                                       (Signature)


                                               /s/ Neil Harris/Secretary
                                        ----------------------------------------
                                                       (Name/Title)



Attention.  Intentional  misstatements  or omissions of fact constitute  federal
criminal violations (see 18 U.S.C. 1001).




                               Page 8 of 8 Pages
<PAGE>


                                   SCHEDULE I
                                   ----------

                       DIRECTORS AND EXECUTIVE OFFICERS OF
                         SHIRE PHARMACEUTICALS GROUP plc


     The name, present principal  occupation or employment,  and the name of any
corporation or other organization in which such employment is conducted, of each
of the  directors  and  executive  officers of Shire  Pharmaceuticals  Group plc
("Shire")  is set forth below.  Except as set forth below each of the  directors
and executive officers is a citizen of the United Kingdom.  The business address
of each  director and officer is Shire  Pharmaceuticals  Group plc,  East Anton,
Andover,   Hampshire  SP10  5RG,  England.  Unless  otherwise  indicated,   each
occupation set forth  opposite an executive  officer's name refers to employment
with BP.

Name and Business         Present Principal Occupation or Employment
- -----------------         ------------------------------------------

Rolf Stahel               Chief Executive
Stephen Stamp             Group Finance Director
Dr. Wilson Totten         Group R&D Director
Dr. James Cavanaugh       President, HealthCare Ventures LLC
(US Citizen)
Dr. Barry Price           Chemist
Jack Khattar              President and Chief Executive, Shire Laboratories Inc.
(US Citizen)
Trevor Davis              Managing Director, Shire Pharmaceuticals Ltd.
Neil Harris               Head of Legal Affairs, Company Secretary
William Nuerge            President and Chief Executive, Shire Richwood Inc.
(US Citizen)
Dr. Bernard Canavan       Director
(US Citizen)


                                      I-1



                          AGREEMENT AND PLAN OF MERGER

                                      AMONG

                        SHIRE PHARMACEUTICALS GROUP plc,

                            RUBY ACQUISITION SUB INC.

                                       AND

                       ROBERTS PHARMACEUTICAL CORPORATION

                            DATED AS OF JULY 26, 1999

                               -------------------




<PAGE>

                               TABLE OF CONTENTS
                                                                            Page
                                    ARTICLE I

                                   DEFINITIONS

1.1.  Definitions..............................................................2

                                   ARTICLE II

                  THE MERGER; CONVERSION AND EXCHANGE OF STOCK

2.1.  Merger..................................................................10
2.2.  Effective Time..........................................................10
2.3.  Effects of the Merger...................................................11
2.4.  Further Assurances......................................................11
2.5.  Merger Consideration....................................................11
2.6.  Exchange Provisions.....................................................13
2.7.  Consideration for Ordinary Shares.......................................15
2.8.  Tax-Free Reorganization.................................................15

                                   ARTICLE III

                         REPRESENTATIONS AND WARRANTIES

3.1.  Representations and Warranties of Roberts...............................15
      (a)       Organization; Standing and Power..............................16
      (b)       Subsidiaries and Investments..................................16
      (c)       Capitalization................................................17
      (d)       Authority.....................................................18
      (e)       Noncontravention..............................................18
      (f)       Government Approval; Consents.................................19
      (g)       SEC Documents.................................................19
      (h)       Information Supplied..........................................19
      (i)       Absence of Certain Changes or Events..........................20
      (j)       Compliance with Law...........................................21
      (k)       Affiliate Arrangements........................................21
      (l)       Transaction Fees..............................................21
      (m)       Litigation....................................................22
      (n)       Taxes and Tax Returns.........................................22
      (o)       Real Property.................................................23
      (p)       Licenses, Permits and Authorizations..........................24
      (q)       ERISA and Employee Matters....................................24
      (r)       Labor Relations...............................................26
      (s)       Intellectual Property Rights..................................27
      (t)       Insurance.....................................................28



                                      -i-
<PAGE>

      (u)       Books and Records.............................................28
      (v)       Undisclosed Liabilities.......................................29
      (w)       FDA, DEA Matters..............................................29
      (x)       Environmental Matters.........................................31
      (y)       Products......................................................33
      (z)       Marketing Practices...........................................34
      (aa)      Affiliates....................................................34
      (bb)      Pooling.......................................................34
      (cc)      Business Combination..........................................34
3.2.  Representations and Warranties of Shire.................................34
      (a)       Organization; Standing and Power..............................35
      (b)       Subsidiaries and Investments..................................35
      (c)       Capitalization................................................36
      (d)       Authority.....................................................36
      (e)       Noncontravention..............................................37
      (f)       Government Approval; Consents.................................37
      (g)       Reports and Financial Statements..............................38
      (h)       Information Supplied..........................................38
      (i)       Absence of Certain Changes or Events..........................39
      (j)       Compliance with Law...........................................40
      (k)       Affiliate Arrangements........................................40
      (l)       Transaction Fees..............................................40
      (m)       Litigation....................................................41
      (n)       Taxes and Tax Returns.........................................41
      (o)       Real Property.................................................42
      (p)       Licenses, Permits and Authorizations..........................42
      (q)       ERISA and Employee Matters....................................43
      (r)       Labor Relations...............................................45
      (s)       Intellectual Property Rights..................................45
      (t)       Insurance.....................................................46
      (u)       Books and Records.............................................46
      (v)       Undisclosed Liabilities.......................................47
      (w)       FDA, DEA Matters..............................................47
      (x)       Environmental Matters.........................................49
      (y)       Products......................................................51
      (z)       Marketing Practices...........................................52
      (aa)      Ordinary Shares...............................................52
      (bb)      Pooling.......................................................52
      (cc)      Merger Consideration..........................................52
      (dd)      Active Trade or Business......................................53
      (ee)      Asset Acquisitions............................................53
      (ff)      Ownership of Roberts Shares...................................53

                                   ARTICLE IV

                              COVENANTS OF ROBERTS

4.1.  Regular Course of Business..............................................54


                                      -ii-
<PAGE>


4.2.  Certain Prohibited Activities...........................................54
4.3.  Notice of Certain Events................................................55
4.4.  Access..................................................................56
4.5.  Approvals...............................................................56
4.6.  No Solicitation.........................................................56
4.7.  Pooling of Interests....................................................57
4.8.  ISRA....................................................................58

                                    ARTICLE V

                     COVENANTS OF SHIRE AND ACQUISITION SUB

5.1.  Regular Course of Business..............................................58
5.2.  Certain Prohibited Activities...........................................58
5.3.  Notice of Certain Events................................................59
5.4.  Access..................................................................60
5.5.  Approvals...............................................................60
5.6.  No Solicitation.........................................................60
5.7.  Pooling of Interests....................................................61
5.8.  Indemnification.........................................................62

                                   ARTICLE VI

                          AGREEMENTS REGARDING OPTIONS
                               AND OTHER BENEFITS

6.1.  Stock Option Plans......................................................63
6.2.  Continuation of Benefits................................................64
6.3.  Severance Policy and Other Agreements...................................64
6.4.  1999 Bonus..............................................................64
6.5.  Waiver of Preexisting Conditions; Credit for Deductibles; Service
        Credit................................................................65

                                   ARTICLE VII

                              CONDITIONS PRECEDENT

7.1.   Conditions to the Obligations of Each Party to Effect the Merger.......65
       (a)       Shareholder Approvals........................................65
       (b)       Certain Approvals............................................65
       (c)       No Proceeding or Litigation..................................65
       (d)       Securities Laws..............................................66
7.2.   Additional Conditions to the Obligations of Roberts....................66
       (a)       Agreements...................................................66
       (b)       Representations and Warranties...............................66
       (c)       Officer's Certificate........................................66


                                      -iii-
<PAGE>

       (d)       Consents from Third Parties..................................66
       (e)       Listing......................................................66
       (f)       Tax Opinions.................................................67
       (g)       Pooling Letter...............................................67
       (h)       Nasdaq.......................................................67
7.3.   Additional Conditions to the Obligations of Shire and Acquisition Sub..67
       (a)       Agreements...................................................68
       (b)       Representations and Warranties...............................68
       (c)       Roberts Officer's Certificate................................68
       (d)       Pooling Letter...............................................68

                                  ARTICLE VIII

                                OTHER AGREEMENTS

8.1.   Preparation of Form F-4, Form F-6, the Proxy Statement and the UK
          Disclosure Document.......... ......................................68
8.2.   Roberts Shareholders Meeting...........................................69
8.3.   Shire Shareholders Meeting.............................................69
8.4.   Acquisition Sub Actions................................................70

                                   ARTICLE IX

                        TERMINATION, AMENDMENT AND WAIVER

9.1.   Termination............................................................70
9.2.   Effect of Termination..................................................72
9.3.   Amendment..............................................................74
9.4.   Waiver.................................................................74

                                    ARTICLE X

                               GENERAL PROVISIONS

10.1.  Public Statements......................................................75
10.2.  Notices................................................................75
10.3.  Interpretation.........................................................76
10.4.  Counterparts...........................................................76
10.5.  Entire Agreement.......................................................76
10.6.  Governing Law..........................................................77
10.7.  Validity...............................................................77
10.8.  Assignment.............................................................77
10.9.  Expenses...............................................................77
10.10. Enforcement............................................................77


                                      -iv-

<PAGE>



EXHIBITS

Exhibit 1       Option Agreement
Exhibit 2-A     Shareholder Agreement - Roberts Shareholders
Exhibit 2-B     Shareholder Agreement - Shire Shareholders
Exhibit 3       Section 145 Letter


SCHEDULES

Schedule 1      Entities Required to Execute the Shareholder Agreement
Schedule 2      Knowledge Officers
Schedule 3      Officers and Directors of Surviving Corporation


                                      -v-

<PAGE>

                          AGREEMENT AND PLAN OF MERGER


     AGREEMENT AND PLAN OF MERGER (this "Agreement"), dated as of July 26, 1999,
among Shire Pharmaceuticals Group plc, a public limited company organized under
the laws of England and Wales ("Shire"), Ruby Acquisition Sub Inc., a New Jersey
corporation ("Acquisition Sub") and a direct wholly owned Subsidiary of Shire,
and Roberts Pharmaceutical Corporation, a New Jersey corporation ("Roberts").

     WHEREAS, the parties hereto desire to consummate a merger (the "Merger")
whereby Acquisition Sub will be merged with and into Roberts and Roberts will be
the surviving corporation in the Merger, all upon the terms and conditions set
forth herein and in accordance with the New Jersey Business Corporation Act
("New Jersey Law");

     WHEREAS, the respective Boards of Directors (or a duly authorized committee
thereof) of each of Shire, Acquisition Sub and Roberts have approved this
Agreement, the Merger and the other transactions contemplated hereby;

     WHEREAS, the Merger is intended to be treated as a tax-free reorganization
pursuant to the provisions of Section 368(a)(1)(A) and Section 368(a)(2)(E) of
the Internal Revenue Code of 1986, as amended (the "Code");

     WHEREAS, concurrently with the execution of this Agreement and as a
condition and inducement to Shire and Acquisition Sub to enter into this
Agreement Roberts has granted to Shire an irrevocable option to acquire
authorized but unissued shares of common stock, par value $.01 per share of
Roberts (the "Common Stock") representing 19.9% of the outstanding shares of
Common Stock as provided in an Option Agreement in the form attached hereto as
Exhibit 1; and

     WHEREAS, concurrently with the execution of this Agreement and as a
condition and inducement to the parties to enter into this Agreement, the
persons listed on Schedule 1-A hereto have committed to vote in favor of
approving this Agreement as provided in a Shareholder Agreement in the form
attached hereto as Exhibit 2-A and the entity listed on Schedule 1-B hereto has
committed to vote in favor of approving this Agreement as provided in a
Shareholder Agreement in the form attached hereto as Exhibit 2-B.





<PAGE>
                                      -2-


     NOW, THEREFORE, in consideration of the premises and the representations,
warranties and agreements herein contained, the parties hereby agree as follows:


                                    ARTICLE I

                                   DEFINITIONS


     1.1. Definitions. For all purposes of this Agreement, except as otherwise
expressly provided or unless the context otherwise requires, the terms defined
in this Article have the meanings assigned to them in this Article:

     "Acquisition Sub" has the meaning set forth in the preamble hereto.

     "Agreement" has the meaning set forth in the preamble hereto.

     "Business Day" means a day other than a Saturday, a Sunday or a day on
which banks in New York, New York or London, England are permitted or required
by law to close.

     "Cash Equivalents" means (a) cash, (b) marketable direct obligations issued
by the United States government or any agency thereof and backed by the full
faith and credit of the United States, in each case maturing within three months
from the date of acquisition thereof, and (c) investments in money market funds
which invest substantially all of their assets in assets of the types described
in clauses (a) and (b) of this definition.

     "CERCLA" has the meaning set forth in Section 3.1(x)(v).

     "Certificate of Merger" has the meaning set forth in Section 2.2.

     "Closing" has the meaning set forth in Section 2.2.

     "Closing Date" has the meaning set forth in Section 2.2.

     "Code" has the meaning set forth in the preamble hereto.



<PAGE>
                                      -3-


     "Common Stock" has the meaning set forth in the preamble hereto.

     "Constituent Corporations" has the meaning set forth in Section 2.1.

     "DEA" has the meaning set forth in Section 3.1(w).

     "Depositary" has the meaning set forth in Section 2.5(f).

     "DOJ" has the meaning set forth in Section 3.1(w)

     "Effective Time" has the meaning set forth in Section 2.2.

     "Employment Obligations" has the meaning set forth in Section 3.1(q).

     "Environmental Law" means CERCLA, the Resource Conservation and Recovery
Act of 1976, as amended, the New Jersey Industrial Site Recovery Act ("ISRA"),
the Illinois Responsible Property Transfer Act ("RPTA"), the Toxic Substances
Control Act, as amended, and any other applicable federal, state, local or
foreign statute, rule, regulation, order, judgment, directive, decree or the
common law regulating, relating to, or imposing liability or standards of
conduct concerning air emissions, water discharges, noise emissions, or exposure
to or the release or threatened release or discharge of any Hazardous Material
into the environment, the generation, handling, use, treatment, storage,
transport, disposal or remediation of any Hazardous Material, or otherwise
concerning pollution or the protection of the outdoor or indoor environment,
(including, without limitation, ambient or indoor air, surface water,
groundwater, soil, subsurface strata and natural resources, including, without
limitation, wetlands, flora and fauna, or public or employee health or safety,
or the experimental use of animals or disposal of animal carcasses).

     "Environmental Permit" means any permit, license, approval, consent or
other authorization by a federal, state, local or non-U.S. government or
regulatory entity pursuant to any Environmental Law.

     "Equity Equivalent" has the meaning set forth in Section 3.1(c).



<PAGE>
                                      -4-


     "ERISA" has the meaning set forth in Section 3.1(q).

     "Exchange Act" means the U.S. Securities Exchange Act of 1934, as amended.

     "Exchange Agent" has the meaning set forth in Section 2.6(b).

     "Exchange Ratio" has the meaning set forth in Section 2.5(a).

     "FDA" has the meaning set forth in Section 3.1(w).

     "Filed SEC Documents" has the meaning set forth in Section 3.1(i).

     "Form F-4" has the meaning set forth in Section 3.1(h).

     "Form F-6" has the meaning set forth in Section 8.1.

     "FSA" means The Financial Services Act 1986 of the United Kingdom.

     "Hazardous Material" means any pollutant, contaminant, or hazardous, toxic,
medical, biohazardous, infectious or dangerous waste, substance, constituent or
material, any asbestos, any petroleum, oil (including crude oil or any fraction
thereof), any radioactive substance, animal carcass, any toxin, chemical, virus,
infectious disease or disease-causing agent, or any other substance, waste,
constituent, chemical or material that can give rise to liability under any
Environmental Law.

     "Holders" means the holders of record of certificates of Common Stock as of
the Effective Time.

     "Indebtedness" means with respect to any entity (a) all obligations for
borrowed money, (b) all obligations evidenced by bonds, debentures, notes or
other similar instruments, (c) all obligations for the reimbursement of any
obligor on any letter of credit, banker's acceptance or similar credit
transaction, (d) all obligations secured by a Lien on property or assets of such
entity, (e) financing leases which would be treated as debt under either US GAAP
or UK GAAP and (f) guarantees and other contingent obligations in respect of
Indebtedness referred to in clauses (a) through (e) above.



<PAGE>
                                      -5-


     "Intellectual Property" has the meaning set forth in Section 3.1(s)(i).

     "knowledge" will be deemed to be present as to Roberts when the matter in
question was actually known by an officer of Roberts identified on Schedule 2-A
attached hereto and will be deemed to be present as to Shire when the matter in
question was actually known by an officer of Shire identified on Schedule 2-B
attached hereto.

     "Lien" means any lien, claim, pledge, assignment, hypothecation,
conditional sale, retention of title, mortgage, deed of trust, pledge, security
interest, charge or encumbrance of any kind other than a mechanic's,
warehousemen's or similar statutory lien or any agreement to provide any of the
foregoing.

     "LSE" means The London Stock Exchange.

     "MCA" has the meaning set forth in Section 3.1(w).

     "Merger" has the meaning set forth in the preamble hereto.

     "Merger Consideration" has the meaning set forth in Section 2.5(a).

     "New Jersey Law" has the meaning set forth in the preamble hereto.

     "Option" means a right and option to purchase one share of Common Stock
which was granted pursuant to either of the Roberts Option Plans.

     "Optionee" has the meaning set forth in Section 6.1.

     "Ordinary Shares" means validly issued, fully paid and nonassessable
ordinary shares, with a nominal value of U.K. five pence each, of Shire.

     "Permits" means all approvals, authorizations, qualifications, consents,
licenses, franchises, orders and other permits of all governmental or regulatory
agencies or bodies, whether federal, state, local or non-U.S.

     "Permitted Lien" means (i) any Lien for Taxes not yet due or delinquent or
being contested in good faith by appropriate proceedings for which adequate
reserves have




<PAGE>
                                      -6-


been established in accordance with US GAAP or UK GAAP, as the case may be, (ii)
any statutory Lien arising in the ordinary course of business by operation of
law with respect to a liability that is not yet due or delinquent and (iii) any
minor imperfection of title or similar Lien which individually or in the
aggregate with other such Liens does not materially impair the value of the
property subject to such Lien or the use of such property in the conduct of the
business of Roberts or Shire, as the case may be, or any of its Subsidiaries.

     "Proxy Statement" means a proxy statement relating to the approval by the
shareholders of Roberts of this Agreement (as amended or supplemented from time
to time).

     "Public UK Documents" has the meaning set forth in Section 3.2(i).

     "Rights" means the Rights issued pursuant to the Rights Agreement.

     "Rights Agreement" means the Rights Agreement, dated as of December 16,
1996, between Roberts and Continental Stock Transfer and Trust Company, as
amended through the date hereof.

     "Roberts" has the meaning set forth in the preamble hereto.

     "Roberts Acquisition Transaction" has the meaning set forth in Section
4.6(a).

     "Roberts Disclosure Schedule" has the meaning set forth in Section 3.1.

     "Roberts Governmental Approvals" has the meaning set forth in Section
3.1(f).

     "Roberts Insurance Policies" has the meaning set forth in Section 3.1(t).

     "Roberts Intellectual Property" has the meaning set forth in Section
3.1(s)(i).

     "Roberts Material Adverse Effect" means any condition, change or effect
that is materially adverse to the business, results of operations or financial
condition of Roberts and its Subsidiaries taken as a whole, but exclud-




<PAGE>
                                      -7-


ing conditions, changes or effects that (a) are caused by general economic
conditions or conditions affecting the pharmaceutical industry as a whole,
whether in the United States or internationally, which conditions do not affect
Roberts and its Subsidiaries in a disproportional manner or (b) are related to
or result from any action or inaction on the part of Shire or any of its
affiliates.

     "Roberts Option Plans" means Roberts' Incentive Stock Option Plan, Equity
Incentive Plan, Restricted Stock Option Plan and Employee Stock Purchase Plan.

     "Roberts Product Sites" has the meaning set forth in Section 3.1(x)(v).

     "Roberts Shareholder Approval" has the meaning set forth in Section 3.1(d).

     "Roberts Shareholders Meeting" has the meaning set forth in Section 8.2.

     "Roberts Superior Proposal" has the meaning set forth in Section 4.6(b).

     "Roberts Third Party Approvals" has the meaning set forth in Section
3.1(f).

     "Roberts Third Party Site" has the meaning set forth in Section
3.1(x)(vi)."SARs" has the meaning set forth in Section 3.1(c).

     "SEC" means the Securities and Exchange Commission.

     "SEC Documents" has the meaning set forth in Section 3.1(g).

     "Securities Act" means the U.S. Securities Act of 1933, as amended.

     "Shareholder Protection Act" means Chapter 10A of the New Jersey Law.

     "Shire" has the meaning set forth in the preamble hereto.

     "Shire Acquisition Transaction" has meaning set forth in Section 5.6.




<PAGE>
                                      -8-


     "Shire ADRs" means the American Depositary Receipts representing the Shire
ADSs issued pursuant to a Deposit Agreement, dated as of April 1, 1998, between
Shire and the Depositary.

     "Shire ADSs" means American Depositary Shares, each representing three
Ordinary Shares, of Shire.

     "Shire Disclosure Schedule" has the meaning set forth in Section 3.2.

     "Shire Governmental Approvals" has the meaning set forth in Section 3.2(f).

     "Shire Insurance Policies" has the meaning set forth in Section 3.2(t).

     "Shire Intellectual Property" has the meaning set forth in Section
3.2(s)(i).

     "Shire Material Adverse Effect" means any condition, change or effect that
is materially adverse to the business, results of operations or financial
condition of Shire and its Subsidiaries taken as a whole, but excluding
conditions, changes or effects that (a) are caused by general economic
conditions or conditions affecting the pharmaceutical industry as a whole,
whether in the United Kingdom or internationally, which conditions do not affect
Shire and its Subsidiaries in a disproportionate manner or (b) are related to or
result from any action or inaction on the part of Roberts or any of its
affiliates.

     "Shire Option Plans" means Shire's SHL Scheme, SPC Scheme, Executive Scheme
(Part A and Part B), Sharesave Scheme, Employee Stock Purchase Plan, Pharmavene
Stock Option Plan and Richwood Stock Option Plan, collectively.

     "Shire Product Sites" has the meaning set forth in Section 3.2(x)(v).

     "Shire Share Value" means one-third of the average of the last reported
sale price per Shire ADR on the Nasdaq National Market over the fifteen
consecutive trading days ending on the third trading day immediately preceding
the Closing Date.

     "Shire Shareholder Approval" has the meaning set forth in Section 3.2(d).




<PAGE>
                                      -9-


     "Shire Shareholders Meeting" has the meaning set forth in Section 8.3.

     "Shire Superior Proposal" has the meaning set forth in Section 5.6(b).

     "Shire Third Party Approvals" has the meaning set forth in Section 3.2(f).

     "Shire Third Party Site" has the meaning set forth in Section 3.2(x)(vi).

     "Subsidiary" of any person means (i) any corporation of which the
outstanding capital stock having at least a majority of the votes entitled to be
cast in the election of directors under ordinary circumstances shall at the time
be owned, directly or indirectly, by such person or (ii) any other person of
which at least a majority of the voting interest under ordinary circumstances is
at the time, directly or indirectly, owned by such person.

     "Surviving Corporation" has the meaning set forth in Section 2.1.

     "Tax" or "Taxes" means (i) all federal, state, local or non-U.S. taxes,
charges, fees, imposts, levies or other assessments, including, without
limitation, all net income, alternative minimum, gross receipts, capital, sales,
use, ad valorem, value added, transfer, franchise, profits, inventory, capital
stock, license, withholding, payroll, employment, social security, unemployment,
excise, severance, stamp, occupation, property and estimated taxes, customs
duties, fees, assessments and charges of any kind whatsoever, (ii) all interest,
penalties, fines, additions to tax or other additional amounts imposed by any
taxing authority in connection with any item described in clause (i) and (iii)
all transferee, successor, several or contractual liability in respect of any
items described in clause (i) or (ii).

     "Tax Returns" means all returns, declarations, reports, estimates,
information returns and statements required to be filed in respect of any Taxes.

     "UK Disclosure Documents" means the documentation necessary for the
implementation of this Agreement including a circular to Shire's shareholders
containing (i) a notice convening an extraordinary general meeting of Shire



<PAGE>
                                      -10-


at which a resolution will be proposed to approve the allotment of share capital
necessary to give effect to this Agreement, and (ii) such other information as
required by applicable law, together with a U.K. prospectus and forms of proxy.

     "UK GAAP" has the meaning set forth in Section 3.2(g).

     "UK Prospectus" means a prospectus prepared in accordance with the FSA with
respect to the Ordinary Shares.

     "US GAAP" has the meaning set forth in Section 3.1(g).


                                   ARTICLE II

                  THE MERGER; CONVERSION AND EXCHANGE OF STOCK

     2.1. Merger. At the Effective Time, in accordance with and subject to the
terms and conditions of this Agreement and New Jersey Law, Acquisition Sub shall
be merged with and into Roberts and Roberts shall continue its corporate
existence under New Jersey Law as the surviving corporation (Acquisition Sub and
Roberts are sometimes referred to herein collectively as the "Constituent
Corporations," and Roberts, as the surviving corporation in the Merger, is
sometimes referred to herein as the "Surviving Corporation").

     2.2. Effective Time. Subject to the provisions of this Agreement, the
parties agree to cause to be duly executed a Certificate of Merger (the
"Certificate of Merger"), which shall be duly delivered to the Secretary of
State for the State of New Jersey for filing as provided by New Jersey Law. The
Merger shall become effective upon the filing of the Certificate of Merger with
the Secretary of State for the State of New Jersey (the "Effective Time"). Prior
to such filings of the Certificate of Merger, a closing (the "Closing") will be
held at the offices of Cahill Gordon & Reindel, 80 Pine Street, New York, New
York 10005, which shall be on the second Business Day after the satisfaction or
waiver of the conditions set forth in Article VII hereof, unless another time,
date or place is agreed by the parties hereto or unless this Agreement has been
terminated in accordance with its terms. The date of the Closing shall be
referred to herein as the "Closing Date." The




<PAGE>
                                      -11-


parties agree that the Effective Time shall occur on the Closing Date.

     2.3. Effects of the Merger. At the Effective Time, (a) the effects of the
Merger shall be as provided under all applicable provisions of New Jersey Law,
(b) the Certificate of Incorporation of Roberts as in effect immediately prior
to the Effective Time shall be the Certificate of Incorporation of the Surviving
Corporation until thereafter amended as provided therein and in accordance with
New Jersey Law, (c) the By-Laws of Roberts as in effect immediately prior to the
Effective Time shall be the By-Laws of the Surviving Corporation until
thereafter amended as provided therein and in accordance with New Jersey Law,
(d) the individuals listed on Schedule 3-A shall be the officers of the
Surviving Corporation until the earlier of their resignation or removal or until
their successors have been duly elected and qualified in accordance with the
Certificate of Incorporation and By-Laws of the Surviving Corporation, and (e)
the individuals listed on Schedule 3-B shall be the directors of the Surviving
Corporation until the earlier of their resignation or removal or until their
successors have been duly elected and qualified in accordance with the
Certificate of Incorporation and By-Laws of the Surviving Corporation.

     2.4. Further Assurances. If, at any time after the Effective Time, the
Surviving Corporation shall consider or be advised that any deeds, bills of
sale, assignments, assurances or any other actions or things are necessary or
desirable to vest, perfect or confirm of record or otherwise in the Surviving
Corporation its right, obligation, title or interest in, to or under any of the
rights, properties or assets of either of the Constituent Corporations as a
result of, or in connection with, the Merger or otherwise to carry out this
Agreement, the officers and directors of the Surviving Corporation shall be
authorized to execute and deliver, in the name and on behalf of each of the
Constituent Corporations or otherwise, all such deeds, bills of sale,
assignments and assurances and to take and do, in the name and on behalf of each
of the Constituent Corporations or otherwise, all such other actions and things
as may be necessary or desirable to vest, perfect or confirm any and all right,
obligation, title and interest in, to and under such rights, properties or
assets in the Surviving Corporation or otherwise to carry out this Agreement so
long as such actions and things are consistent with the terms of this Agreement
and the Certificate of Merger.

     2.5. Merger Consideration. (a) At the Effective Time, by virtue of the
Merger and without any action on the



<PAGE>
                                      -12-


part of the Holders, each issued and outstanding share of Common Stock (other
than shares canceled in accordance with Section 2.5(d)) together with the
associated Right shall be converted into the right to receive from Shire a
number of Ordinary Shares (the "Merger Consideration") determined as set forth
below (the "Exchange Ratio"):

          (i) If the Shire Share Value is equal to or greater than $7.91 and
     equal to or less than $9.67, the Exchange Ratio shall be 3.4122;

          (ii) If the Shire Share Value is equal to or greater than $7.03 and
     less than $7.91, the Exchange Ratio shall be determined by dividing $27.00
     by the Shire Share Value;

          (iii) If the Shire Share Value is less than $7.03, the Exchange Ratio
     shall be 3.8407;

          (iv) If the Shire Share Value is greater than $9.67 and less than or
     equal to $10.55, the Exchange Ratio shall be determined by dividing $33.00
     by the Shire Share Value; and

          (v) If the Shire Share Value is greater than $10.55, the Exchange
     Ratio shall be 3.1280.

     (b) Each issued and outstanding share of capital stock of Acquisition Sub
shall be canceled.

     (c) In consideration of the cancellation of shares of capital stock of
Acquisition Sub pursuant to Section 2.5(b) and the issuance of Ordinary Shares
pursuant to Section 2.5(a), the Surviving Corporation shall issue one fully paid
and nonassessable share of its common stock, par value $.01 per share, to Shire
for each share canceled pursuant to Section 2.5(b).

     (d) Each share of Common Stock (and associated Rights) that is owned by
Roberts or any Subsidiary of Roberts, or Shire or any Subsidiary of Shire, shall
automatically be canceled and retired and shall cease to exist, and no Ordinary
Shares or other consideration shall be delivered in exchange therefor.

     (e) The parties acknowledge that listing of the Ordinary Shares comprising
the Merger Consideration on the London Stock Exchange will not be permitted
unless and until this Agreement is unconditional in all respects, including the
filings of the Certificate of Merger having taken place as pro-



<PAGE>
                                      -13-


vided for in Section 2.2. The parties therefore agree that, without prejudice to
Articles VII, VIII and IX of this Agreement, once the Ordinary Shares have been
allotted, they shall use their respective best efforts to procure that filings
of the Certificate of Merger takes place immediately before 9:30 a.m. (New York
time) on the Closing Date, and that the Ordinary Shares to be issued pursuant to
this Agreement are admitted to the Official List of the London Stock Exchange at
2:30 p.m. (London time).

     (f) Notwithstanding Section 2.5(a), unless the Holders otherwise elect,
Shire will provide Holders with one-third of a Shire ADS (represented by Shire
ADRs) for each Ordinary Share such Holder would be entitled to receive pursuant
to Section 2.5(a). Holders must irrevocably elect to receive all or any portion
of their Ordinary Shares as Ordinary Shares in lieu of such Shire ADSs at the
time they surrender their certificates representing shares of Common Stock in
accordance with the provisions described in Section 2.6. The receipt of Shire
ADSs will be deemed for all purposes of this Agreement as the receipt of the
underlying Ordinary Shares and such Shire ADSs will be deemed for all purposes
of this Agreement to constitute Merger Consideration. Shire will pay all fees
and expenses associated with the issuance of the Ordinary Shares constituting
Shire ADSs to Morgan Guaranty Trust Company of New York, as depositary (the
"Depositary"), for the issuance by the Depositary of the associated Shire ADRs.

     (g) Shire shall not be required to pay any fractional Ordinary Shares or
Shire ADSs pursuant to this Section 2.5. In lieu of receiving a fractional
Ordinary Share or Shire ADS, each Holder otherwise entitled to (i) a fractional
Ordinary Share shall receive cash (without interest) in an amount equal to (a)
the latest closing mid-market price of the Ordinary Shares on the London Stock
Exchange on the day immediately following the Closing Date divided by (b) the
fractional interest of an Ordinary Share that would otherwise be payable and
(ii) a fractional Shire ADS shall receive cash (without interest) in an amount
equal to (a) the last reported sale price of Shire ADRs on the Nasdaq National
Market for the day immediately following the Closing Date divided by (b) the
fractional interest of a Shire ADS that would otherwise be payable.

     2.6. Exchange Provisions. (a) At the Effective Time, all shares of Common
Stock (and associated Rights), by virtue of the Merger and without any action on
the part of the Holders, shall no longer be outstanding and shall be canceled
and retired and shall cease to exist, and each Holder of a cer-



<PAGE>
                                      -14-


tificate representing any such share of Common Stock shall thereafter cease to
have any rights with respect to such share of Common Stock (and associated
Right) except the right to receive the Merger Consideration for such share of
Common Stock (and associated Right) specified in Section 2.5.

     (b) Prior to the Effective Time, Shire shall designate a bank or trust
company reasonably satisfactory to Roberts to act as Exchange Agent hereunder
(the "Exchange Agent"). At the Effective Time, Shire shall (i) issue to and
deposit with the Depositary, for the benefit of the holders of shares of Common
Stock converted into Shire ADSs in accordance with Sections 2.5(a) and (f),
Ordinary Shares in an amount sufficient to permit the Depositary to issue Shire
ADSs representing the number of Shire ADSs issuable pursuant to Sections 2.5(a)
and (f) and (ii) deposit, in trust, with the Exchange Agent for the benefit of
the Holders, Ordinary Shares constituting the Merger Consideration. As soon as
practicable after the Effective Time, the Surviving Corporation shall cause the
Exchange Agent to mail to each Holder (i) a form of letter of transmittal
specifying that delivery shall be effected, and risk of loss and title to
certificates of Common Stock shall pass, only upon proper delivery of such
certificates to the Exchange Agent and (ii) instructions for use in surrendering
such certificates in exchange for the Merger Consideration set forth in Section
2.5. Such letter of transmittal shall also indicate that Holders have an
irrevocable right to elect to receive all or any portion of their Ordinary
Shares as Ordinary Shares in lieu of Shire ADSs as set forth in Section 2.5(f).
Upon surrender of any such certificate for cancellation to the Exchange Agent,
together with such letter of transmittal, duly executed, the holder of such
certificate shall be entitled to receive in exchange therefor the Merger
Consideration. Shire shall cause the Depositary to issue Shire ADRs through and
upon the instructions of the Exchange Agent, for the benefit of the holders of
shares of Common Stock who have not elected to receive Ordinary Shares pursuant
to Section 2.5(f). Neither the Exchange Agent nor any party hereto shall be
liable to any Holder for any amount paid to a public official pursuant to any
applicable abandoned property, escheat or similar law. Shire and the Exchange
Agent shall be entitled to deduct and withhold from the consideration otherwise
payable pursuant to this Agreement to any Holder such amounts as the Surviving
Corporation or the Exchange Agent is required to deduct and withhold under the
Code or any provision of national, state or local law, with respect to the
making of such payment. To the extent such amounts are so withheld, such
withheld amounts shall be treated for all purposes of this Agreement as having
been paid




<PAGE>
                                      -15-


to the Holder in respect of whom such deduction and withholding was made. Any
Merger Consideration payable to Holders pursuant to Section 2.5 which remains
undistributed to the Holders for a period of six months after the Closing Date
shall be delivered to the Surviving Corporation upon its request, and any
Holders who have not surrendered to the Exchange Agent certificates for Common
Stock or complied with the instructions in the letter of transmittal, as the
case may be, shall thereafter look only to the Surviving Corporation for payment
of such Merger Consideration. The Surviving Corporation shall instruct the
Exchange Agent to invest all cash held by it in Cash Equivalents. Interest
earned on such Cash Equivalents shall be paid to the Surviving Corporation.

     (c) Until so surrendered, each certificate representing Common Stock shall
represent, after the Effective Time, solely the right to receive the Merger
Consideration specified in Section 2.5. The Merger Consideration issued upon the
surrender of Common Stock in accordance with the terms hereof shall be deemed to
have been issued in full satisfaction of all rights pertaining to such Common
Stock (and associated Rights).

     2.7. Consideration for Ordinary Shares. The consideration for the allotment
by Shire of Ordinary Shares constituting the Merger Consideration shall be the
cancellation of all shares of Common Stock pursuant to Section 2.6(a).

     2.8. Tax-Free Reorganization. For U.S. income tax purposes, the parties
intend that the Merger be treated as a tax-free reorganization pursuant to the
provisions of Section 368(a)(1)(A) and Section 368(a)(2)(E) of the Code. Each
party hereto agrees not to take any position inconsistent with the foregoing on
any Tax Return, unless required by law.

                                   ARTICLE III

                         REPRESENTATIONS AND WARRANTIES

     3.1. Representations and Warranties of Roberts. Roberts represents and
warrants to Shire and Acquisition Sub that, except (A) as set forth in the
Roberts Disclosure Schedule delivered by Roberts to Shire at or prior to the
execution of this Agreement (the "Roberts Disclosure Schedule") (each section of
which qualifies the correspondingly numbered representation and warranty) and
(B) with respect to paragraphs (j), (m), (o), (p), (q), (r), (t), (w), (x) and
(y) of this Section



<PAGE>
                                      -16-


3.1, as does not have, or could not reasonably be expected to have, individually
or in the aggregate, a Roberts Material Adverse Effect, the following is true
and correct:

          (a) Organization; Standing and Power. Roberts is a corporation duly
     organized, validly existing and in good standing under the laws of the
     State of New Jersey. Roberts has all requisite corporate power and
     authority to own, lease and operate its assets and to carry on its business
     as now being conducted. Roberts is duly qualified as a foreign corporation
     to do business, and is in good standing, in each jurisdiction where the
     character of its assets owned or leased or the nature of its activities
     makes such qualification necessary (such jurisdictions being specified in
     Section 3.1(a) of the Roberts Disclosure Schedule) except where the failure
     to be so qualified would not have a Roberts Material Adverse Effect. Copies
     of the Certificate of Incorporation and By-Laws of Roberts as in effect on
     the date hereof have been previously delivered to Shire.

          (b) Subsidiaries and Investments. Section 3.1(b) of the Roberts
     Disclosure Schedule lists each Subsidiary of Roberts. Each such Subsidiary
     is a corporation duly organized, validly existing and (in applicable
     jurisdictions) in good standing under the laws of its jurisdiction of
     incorporation. Each such Subsidiary has all requisite corporate power and
     authority to own, lease and operate its assets and to carry on its business
     as now being conducted. All such Subsidiaries are duly qualified as foreign
     corporations to do business, and (in applicable jurisdictions) are in good
     standing, in each jurisdiction where the character of their respective
     assets owned or leased or the nature of their respective activities makes
     such qualification necessary, except where the failure to be so qualified
     or in good standing would not have a Roberts Material Adverse Effect. All
     the outstanding shares of capital stock of each such Subsidiary have been
     validly issued and are fully paid (and in applicable jurisdictions,
     nonassessable) and are owned by Roberts, by another Subsidiary of Roberts
     or by Roberts and another such Subsidiary, free and clear of all Liens,
     other than Liens which (individually or in the aggregate) would not have a
     Roberts Material Adverse Effect. Except for the capital stock of its
     Subsidiaries, Roberts does not own any stock, partnership or other equity
     interest in, or any debt or equity securities of, any person or entity.




<PAGE>
                                      -17-


          (c) Capitalization. The authorized capital stock of Roberts consists
     of 110,000,000 shares of capital stock, including 10,000,000 shares of
     Class B Preferred Stock par value $.10 per share (of which 5,500,000 shares
     have been designated as Series B 5% Convertible Preferred Stock, all of
     which have been converted into Common Stock), 500,000 shares of Series A
     Junior Participating Preferred Stock par value $.10 per share and
     100,000,000 shares of Common Stock. At the close of business on July 21,
     1999 (i) 31,889,077 shares of Common Stock were issued and outstanding,
     (ii) 387,594 shares of Common Stock were held by Roberts in its treasury,
     (iii) 3,353,188 shares of Common Stock were reserved for issuance on
     exercise of outstanding options under the Roberts Option Plans, (iv) 150
     shares of Common Stock were reserved for issuance upon the exercise of the
     warrant issued to A.B. Laffer, V.A. Canto & Associates and (v) 500,000
     shares of Series A Junior Participating Preferred Stock were reserved for
     issuance under the Rights Agreement and no other shares of capital stock
     were issued, reserved for issuance or outstanding. All outstanding shares
     of capital stock of Roberts are, and all shares which are reserved for
     issuance will be, when issued in accordance with the Roberts Option Plans,
     duly authorized, validly issued, fully paid and nonassessable and not
     subject to preemptive rights. Except as set forth above, as of the date of
     this Agreement, there are not any securities convertible into or
     exchangeable or exercisable for capital stock ("Equity Equivalent") of any
     of Roberts or any of its Subsidiaries (including, without limitation, any
     option, warrant, right to subscribe, call or commitment of any kind or
     character whatsoever requiring the issuance, sale or transfer by Roberts or
     any of its Subsidiaries of any shares of their capital stock or any
     securities convertible into or exchangeable or exercisable for such capital
     stock). As of the date of this Agreement, there are not any outstanding
     contractual obligations of Roberts or any of its Subsidiaries to
     repurchase, redeem or otherwise acquire any shares of capital stock of
     Roberts or any of its Subsidiaries. Roberts has delivered to Shire a
     complete and correct copy of the Rights Agreement as amended and
     supplemented to the date of this Agreement. There are no outstanding stock
     appreciation, phantom stock, profit participation or similar rights
     (collectively, "SARs") with respect to Roberts. Roberts has delivered to
     Shire a complete list of all outstanding Indebtedness of Roberts and its
     Subsidiaries.




<PAGE>
                                      -18-


          (d) Authority. Roberts has the requisite corporate power and authority
     to execute and deliver this Agreement and, subject to Roberts Shareholder
     Approval (as defined below) and the receipt of the consents and waivers set
     forth in Section 3.1(d) of the Roberts Disclosure Schedule, to consummate
     the transactions contemplated by this Agreement to be consummated by
     Roberts. The execution and delivery of this Agreement by Roberts and the
     consummation of the transactions contemplated hereby have been duly
     authorized by all necessary corporate action on the part of Roberts,
     subject to the approval of this Agreement and the transactions contemplated
     hereby by the affirmative vote of holders of at least two-thirds of the
     shares of Common Stock voted at a meeting (the "Roberts Shareholder
     Approval"). This Agreement has been duly executed and delivered by Roberts
     and constitutes a valid and binding obligation of Roberts, enforceable
     against Roberts in accordance with its terms, subject to applicable
     bankruptcy, insolvency moratorium or other similar laws relating to
     creditors' rights and general principles of equity.

          (e) Noncontravention. Neither the execution and delivery of this
     Agreement by Roberts nor the consummation of the transactions contemplated
     hereby nor compliance by Roberts with any of the provisions hereof will (i)
     violate, conflict with or result in a breach of any provision of, or
     constitute a default (or an event which, with notice or lapse of time or
     both, could constitute a default) under, or result in the termination,
     modification or suspension of, or accelerate the performance required by,
     or result in a right of termination or acceleration under, or result in the
     creation of any Lien upon, right to acquire or obligation to dispose of any
     of the properties, assets or rights of Roberts or any of its Subsidiaries
     under, any of the terms, conditions or provisions of (x) the Certificate of
     Incorporation or By-Laws of Roberts or any of its Subsidiaries or (y) any
     note, bond, mortgage, credit agreement, indenture, deed of trust, license,
     Permit, authorization, lease, agreement or instrument or obligation to
     which Roberts or any of its Subsidiaries is party or by which they are
     bound or to which they or any of their assets may be subject, or (ii)
     violate any judgment, ruling, order, writ, injunction, decree, statute,
     rule or regulation applicable to Roberts or any of its Subsidiaries, their
     operations or any of their assets, except for such violations, conflicts or
     breaches referred to in clauses (i)(y) and (ii) which would not,
     individually or in the aggregate, have a Roberts Material Adverse Effect.



<PAGE>
                                      -19-


          (f) Government Approval; Consents. No consents and approvals are
     required to be obtained by Roberts from non-governmental third parties
     ("Roberts Third Party Approvals") in order to lawfully and contractually
     permit it to perform its obligations under this Agreement and consummate
     the transactions contemplated hereby. No notice to, filing with, or
     authorization, consent or approval of, any federal, state, local or
     non-U.S. public body or authority is necessary for the execution, delivery
     or performance of this Agreement by Roberts or the consummation of the
     transactions contemplated hereby ("Roberts Governmental Approvals").

          (g) SEC Documents. (i) Roberts has filed all required reports,
     schedules, forms, statements and other documents with the SEC since January
     1, 1998 (the "SEC Documents"). As of their respective dates, the SEC
     Documents complied in all material respects with the requirements of the
     Securities Act or the Exchange Act, as the case may be, and the rules and
     regulations of the SEC promulgated thereunder applicable to such SEC
     Documents, and none of the SEC Documents contained any untrue statement of
     a material fact or omitted to state a material fact required to be stated
     therein or necessary in order to make the statements therein, in the light
     of the circumstances under which they were made, not misleading. The
     financial statements of Roberts included in the SEC Documents comply as to
     form in all material respects with applicable accounting requirements and
     the published rules and regulations of the SEC with respect thereto, have
     been prepared in accordance with accounting principles generally accepted
     in the United States ("US GAAP") (except, in the case of unaudited
     statements, as permitted by Form 10-Q of the SEC) applied on a consistent
     basis during the periods involved (except as may be indicated in the notes
     thereto) and fairly present the consolidated financial position of Roberts
     and its consolidated Subsidiaries as of the dates thereof and the
     consolidated results of their operations and cash flows for the periods
     then ended (subject, in the case of unaudited statements, to normal
     year-end audit adjustments).

          (ii) Roberts is eligible to use Form S-3 for the filing of a
     registration statement with the SEC under the Securities Act.

          (h) Information Supplied. None of the information supplied or to be
     supplied by Roberts for inclusion or in-




<PAGE>
                                      -20-


     corporation by reference in (i) the registration statement on Form F-4 to
     be filed with the SEC by Shire in connection with the issuance of Ordinary
     Shares and Shire ADSs in the Merger (the "Form F-4") will, at the time the
     Form F-4 is filed with the SEC, at any time it is amended or supplemented
     or at the time it becomes effective under the Securities Act, contain any
     untrue statement of a material fact or omit to state any material fact
     required to be stated therein or necessary to make the statements therein
     not misleading, (ii) the UK Disclosure Documents will, on the date the UK
     Disclosure Documents are first mailed to the shareholders of Shire or at
     the time of the Shire shareholders meeting, contain any untrue statement of
     a material fact or omit to state any material fact required to be stated
     therein or necessary in order to make the statements therein, in the light
     of the circumstances under which they are made, not misleading or (iii) the
     Proxy Statement will, at the date it is first mailed to Roberts
     shareholders or at the time of the Roberts Shareholders Meeting, contain
     any untrue statement of a material fact or omit to state any material fact
     required to be stated therein or necessary in order to make the statements
     therein, in the light of the circumstances under which they are made, not
     misleading. The Proxy Statement will comply as to form in all material
     respects with the requirements of the Exchange Act and the rules and
     regulations thereunder, except that no representation is made by Roberts
     with respect to statements made or incorporated by reference therein based
     on information supplied by Shire.

          (i) Absence of Certain Changes or Events. Except as disclosed in the
     SEC Documents filed and publicly available prior to the date of this
     Agreement (the "Filed SEC Documents"), since December 31, 1998 there has
     not been (i) any material adverse change in the business, financial
     condition or results of operations of Roberts and its Subsidiaries, taken
     as a whole, (ii) any destruction or loss of (whether or not covered by
     insurance) any property, asset or right that has had or is likely to have a
     Roberts Material Adverse Effect, (iii) any authorization or issuance by
     Roberts of any of its capital stock or the issuance of any debt security or
     other evidence of Indebtedness of Roberts or any of its Subsidiaries, (iv)
     any redemption or other acquisition by Roberts of any of its capital stock
     or by Roberts or any of its Subsidiaries of any of their debt securities or
     other evidences of Indebtedness, or any payment made with respect to any of
     the foregoing (other than any regular, periodic payment of in-





<PAGE>
                                      -21-


     terest made with respect to a debt security or other evidence of
     Indebtedness), (v) any declaration, setting aside or payment of any
     dividend or other distribution or payment (whether in cash, capital stock
     or otherwise) in respect of any capital stock of Roberts, (vi) any disposal
     or lapse of any Roberts Intellectual Property, (vii) any Lien (other than a
     Permitted Lien) incurred on any material property, assets or rights of
     Roberts or any of its Subsidiaries, (viii) any incurrence by Roberts or any
     of its Subsidiaries of any liability which has had or is likely to have a
     Roberts Material Adverse Effect, (ix) any incurrence of Indebtedness or any
     guarantee by Roberts or any of its Subsidiaries of any liability of any
     other person or entity outside of the ordinary course of business, (x) to
     the knowledge of Roberts, any development with respect to regulatory
     approval of any products of Roberts or any of its Subsidiaries which has
     had or is likely to have a Roberts Material Adverse Effect, (xi) to the
     knowledge of Roberts, any development with respect to relationships with
     any contract manufacturer or contract research organization with which
     Roberts or any of its Subsidiaries has a business relationship which has
     had or is likely to have a Roberts Material Adverse Effect or (xii) any
     change in Roberts' Tax accounting methods, any new election made with
     respect to Taxes, any modification or revocation of any existing election
     made with respect to Taxes, or any settlement or other disposition of any
     Tax matter.

          (j) Compliance with Law. Neither Roberts nor any of its Subsidiaries
     is in violation or noncompliance in any material respect with any statute,
     law, ordinance, regulation, rule, order or other legal requirement of any
     government, authority or any other governmental department or agency
     applicable to its business or operations, or any judgment, decree or order
     of any court to which it is a party.

          (k) Affiliate Arrangements. Neither Roberts nor any of its
     Subsidiaries is a party to any contract, agreement, arrangement,
     understanding or other commitment with any director, officer or
     securityholder of Roberts or any of its Subsidiaries or, to the knowledge
     of Roberts, any person or entity controlled by any such person.

          (l) Transaction Fees. Roberts has not retained any broker, finder,
     financial adviser, investment banker or other person or entity which is
     entitled to any brokerage,




<PAGE>
                                      -22-


     finder's or similar fee or commission in connection with this Agreement or
     the transactions contemplated hereby.

          (m) Litigation. There is no claim, action, suit or proceeding pending
     or, to the knowledge of Roberts, threatened against Roberts or any of its
     Subsidiaries or any of their respective properties, assets or rights before
     any court or governmental or regulatory authority or body.

          (n) Taxes and Tax Returns. (i) Roberts has duly and timely filed all
     federal, state, local and non-U.S. Tax Returns required to be filed by it
     and its Subsidiaries, and each such Tax Return is complete and accurate in
     all material respects, (ii) Roberts has timely paid all Taxes due and
     payable by it and its Subsidiaries and has made adequate provision (through
     a current accrual on its most recent financial statements) for any Taxes
     that are not yet due and payable and (iii) Roberts has withheld and paid in
     a timely manner all Taxes required to have been withheld and paid in
     connection with amounts paid or owing to any employee, independent
     contractor, creditor, stockholder or other third party, including amounts
     of or the value of awards and prizes paid to Roberts' employees. Any
     deficiencies or assessments asserted in writing by any taxing authority
     have been paid or fully settled and no issue raised by any such taxing
     authority reasonably could be expected to result in a proposed deficiency
     for any prior, parallel or subsequent period (including periods subsequent
     to the Effective Time). There are no claims or assessments pending (or, to
     the best knowledge of Roberts, threatened) against Roberts or any of its
     Subsidiaries for any alleged federal, state, local or non-U.S. Tax
     deficiency and no issue has been raised in writing by any federal, state,
     local or non-U.S. taxing authority or representative thereof. No consent
     has been filed relating to Roberts pursuant to Section 341 of the Code. No
     claim has ever been made by an authority in a jurisdiction where Roberts
     does not file Tax Returns that it is or may be subject to taxation by that
     jurisdiction. Section 3.1(n) of the Roberts Disclosure Schedule lists all
     federal, state, local and non-U.S. jurisdictions in which Roberts files Tax
     Returns, and indicates those Tax Returns that have been audited and those
     that currently are the subject of audit. Roberts has not consented to an
     extension of the statute of limitations with respect to any Tax period.
     Roberts is not a party to any Tax allocation or sharing agreement. Roberts
     (i) has never been a member of an




<PAGE>
                                      -23-


     "affiliated group" (within the meaning of Section 1504 of the Code) and has
     never been a member of any combined, consolidated, affiliated or unitary
     group for any state, local or non-U.S. Tax purposes and (ii) has no
     liability for the Taxes of any person under Treas. Reg. ss. 1.1502-6 (or
     any similar provision of state, local or non-U.S. law), as a transferee or
     successor, by contract, or otherwise. Roberts has never had any
     "undistributed personal holding company income" (as defined in Section 545
     of the Code). Roberts is not required to make any adjustment pursuant to
     Section 481 of the Code (or any comparable provision of state, local or
     non-U.S. law) by reason of a change in accounting method or otherwise.
     Roberts has never requested a ruling from, or entered into a closing
     agreement with, the Internal Revenue Service or any other taxing authority.
     None of Roberts' assets is "tax-exempt use property" (as defined in Section
     168(h)(1) of the Code) or may be treated as owned by any other person
     pursuant to Section 168(f)(8) of the Internal Revenue Code of 1954 (as in
     effect immediately prior to the enactment of the Tax Reform Act of 1986).
     Roberts is not a party to any agreement or arrangement that provides for
     the payment of any amount that could constitute a "parachute payment"
     within the meaning of Section 280G of the Code. Roberts is not, and has
     never been, a "United States real property holding corporation" within the
     meaning of Section 897 of the Code. Roberts has not made any elections
     under Section 108, 168, 338, 441, 472, 1017, 1033 or 4977 of the Code (or
     any predecessor provisions thereof). Roberts has previously delivered to
     Shire true and complete copies of (i) all federal, state, local and
     non-U.S. income or franchise Tax Returns for each of the last three taxable
     years ending prior to the date of this Agreement (except for those Tax
     Returns that have not yet been filed) and (ii) any audit reports issued
     within the last three years by the Internal Revenue Service or any other
     taxing authority.

          (o) Real Property. Section 3.1(o) of the Roberts Disclosure Schedule
     sets forth a complete and accurate list of all material real property owned
     or leased by Roberts or any of its Subsidiaries, including (i) with respect
     to owned real property, the date of its acquisition, any Liens on or with
     respect to such real property (other than Permitted Liens), the name of the
     holder of any such Lien and the amount and nature of any obligation secured
     by any such Lien and (ii) with respect to leased real property, the name of
     the lessor of such real property, a






<PAGE>
                                      -24-


     list of all instruments and documents governing the terms of such leasehold
     interest, any Lien on or with respect to such leasehold interest (other
     than Permitted Liens), the name of the holder of any such Lien and the
     amount and nature of any obligation secured by any such Lien. Roberts is
     not a lessor with respect to any material real property owned by it or any
     of its Subsidiaries and has not granted any sublease of any leasehold
     interest in any material real property leased by it or any of its
     Subsidiaries. With respect to such material real property, (i) there are no
     eminent domain proceedings pending or threatened against it, (ii) such
     properties and the improvements thereon (including the roof and structural
     portions of each building) are in good operating order and condition,
     subject to ordinary wear and tear, and (iii) the use thereof does not
     violate any zoning or similar land use laws or other government regulations
     other than such violations which, individually or in the aggregate, would
     not adversely affect the ability of the Surviving Corporation to use,
     operate or occupy any of such properties following the Effective Time. The
     real property owned or leased by Roberts and its Subsidiaries is sufficient
     for the conduct of its business.

          (p) Licenses, Permits and Authorizations. Section 3.1(p) of the
     Roberts Disclosure Schedule sets forth a complete and accurate list of all
     material Permits held by or on behalf of Roberts and its Subsidiaries,
     including (i) the agency or body issuing such Permit, (ii) the person or
     entity to whom such Permit was issued and (iii) the date such Permit
     expires or is required to be renewed. Each such Permit is, to the knowledge
     of Roberts, in full force and effect and Roberts, or the person or entity
     who holds such Permit on Roberts' behalf, is in compliance in all material
     respects with all of its obligations with respect thereto, and, to the
     knowledge of Roberts, no event has occurred or condition exists which
     permits or, upon the giving of notice or lapse of time or both, would
     permit revocation, nonrenewal, modification, suspension or termination of
     any such Permit.

          (q) ERISA and Employee Matters. Section 3.1(q) of the Roberts
     Disclosure Schedule sets forth a complete and accurate list of all
     employment and consultancy agreements, all employee benefit plans (within
     the meaning of Section 3(3) of ERISA) or retirement benefits scheme (within
     the meaning of Section 611 of the Income and Corporation Taxes Act 1988)
     and all other written plans, ar-




<PAGE>
                                      -25-


     rangements or policies relating to stock options, stock purchases,
     compensation, deferred compensation, supplemental retirement arrangements,
     other incentive programs, severance, fringe benefits or other employee
     benefits (collectively "Employment Obligations") covering all present and
     former officers, directors, employees, consultants and agents of Roberts
     and its Subsidiaries and any of their spouses or dependents. Roberts has
     made available to Shire true, complete and correct copies of (i) each such
     Employment Obligation, (ii) the most recent annual report on Form 5500 as
     filed with the Internal Revenue Service with respect to each applicable
     Employment Obligation, (iii) the most recent summary plan description (or
     similar document) with respect to each applicable Employment Obligation,
     (iv) each trust agreement and insurance or annuity contract relating to any
     Employment Obligation and (v) the most recent actuarial valuation report
     for each applicable Employment Obligation. (i) Roberts and its Subsidiaries
     are in compliance in all material respects with all applicable provisions
     of the Employee Retirement Income Security Act of 1974, as amended
     ("ERISA"), and the Code with respect to each Employment Obligation, (ii)
     except for PBGC premiums, all of which that are due have been paid, neither
     Roberts nor any of its Subsidiaries has material liability under Title IV
     of ERISA, (iii) neither Roberts nor any of its Subsidiaries has engaged in
     a prohibited transaction or breach of fiduciary duty that would subject it
     to a material tax imposed under Section 4975 of the Code or material
     liability pursuant to Section 409 or 502 of ERISA, (iv) neither Roberts nor
     any of its Subsidiaries has been a party to or contributed to any
     "multiemployer plan" as defined in Section 4001(a) of ERISA, (v) no pension
     plan covering any present or former officers, directors or employees of
     Roberts or any of its Subsidiaries is or has been subject to Title IV of
     ERISA, (vi) except for liability for contributions and benefits pursuant to
     the Employment Obligations, neither Roberts nor any of its Subsidiaries has
     incurred any material liability under or pursuant to Title I or IV of ERISA
     or the penalty, excise tax or joint and several liability provisions of the
     Code relating to employee benefit plans and (vii) except claims for
     benefits payable in the normal operation of such Employment Obligations,
     there are no investigations by any governmental agency, termination
     proceedings or other claims, suits or proceedings against or involving any
     such Employment Obligation or asserting any rights to or claims for
     benefits under any such Employment Obligation. In respect of any Employment
     Obligations




<PAGE>
                                      -26-


     benefiting Roberts UK employees, (i) the only benefits provided are defined
     contribution benefits and no promise, assurance or undertaking has been
     given to any of the employees (whether legally binding or not) as to the
     provision of retirement, death or disability benefits at a particular
     level, (ii) there are not in respect of any retirement benefits scheme or
     the benefits under it any actions, suits or claims pending or threatened
     (other than routine claims or benefits) against the trustees or
     administrators of that scheme or against Shire. Each Employment Obligation
     of Roberts and its Subsidiaries (if any) that is intended to be a
     tax-qualified plan has been the subject of a determination letter from the
     Internal Revenue Service to the effect that such Employment Obligation and
     each related trust is qualified and exempt from Federal income taxes under
     Sections 401(a) and 501(a), as applicable, respectively, of the Code, no
     such determination letter has been revoked, and revocation has not been
     threatened and no event has occurred and no circumstances exist that would
     reasonably be expected to adversely affect the tax qualification of such
     Employment Obligation. Each of the Employment Obligations with respect to
     employees or former employees employed by Roberts or any of its
     Subsidiaries outside of the United States are in compliance in all material
     respects with all applicable law (including, where applicable, Article 141
     of the Treaty of Rome) and, to the extent not mandated by the laws of the
     applicable jurisdiction, copies of the applicable written plan document
     have been made available to Shire.

          (r) Labor Relations. (i) There is no unfair labor practice complaint
     pending against Roberts or any of its Subsidiaries or, to the knowledge of
     Roberts, threatened against them, before the National Labor Relations Board
     or any other U.S. or non-U.S. governmental or regulatory authority, and, to
     the knowledge of Roberts, no grievance or arbitration proceeding arising
     out of or under any of their Employment Obligations is so pending against
     Roberts or any of its Subsidiaries or threatened against them; (ii) to the
     knowledge of Roberts, there is no basis for an unfair labor practice
     finding against Roberts or any of its Subsidiaries; (iii) no strike, labor
     dispute, slowdown or stoppage is pending or, to the knowledge of Roberts,
     threatened against Roberts or any of its Subsidiaries; and (iv) no union
     has ever represented any employee of Roberts or any of its Subsidiaries.




<PAGE>
                                      -27-


          (s) Intellectual Property Rights. (i) Section 3.1(s) of the Roberts
     Disclosure Schedule sets forth a complete and accurate list (including
     registration numbers and dates of filing, renewal and termination, where
     applicable, for each jurisdiction where filed) of all patents, patent
     applications, trademarks, trademark registrations and applications,
     copyrights, copyright applications, service marks, service mark
     registrations and applications and trade names (whether or not registered
     or registrable) ("Intellectual Property") owned by Roberts or any of its
     Subsidiaries which is material to Roberts and its Subsidiaries, taken as a
     whole ("Roberts Intellectual Property"), including any Liens thereon, the
     name of the holder of any such Lien and the amount and nature of any
     obligation secured by any such Lien. All Roberts Intellectual Property is
     owned by Roberts or its Subsidiaries free and clear of all Liens, no
     Roberts Intellectual Property has been canceled, abandoned or otherwise
     terminated and all patent applications, trademark applications and
     copyright applications included in Roberts Intellectual Property have been
     duly filed and are recorded on the public record in the name of Roberts or
     one of its Subsidiaries and all renewal fees have been duly paid other than
     where such action would not have a Roberts Material Adverse Effect. Neither
     Roberts nor any of its Subsidiaries has granted any license or other rights
     with respect to any Roberts Intellectual Property to any other person or
     entity.

          (ii) Roberts has no knowledge that any of its or its Subsidiaries'
     granted patents are invalid; to the knowledge of Roberts, no Roberts
     Intellectual Property is being infringed by any third party in any material
     respect; and, to the knowledge of Roberts, its current operations do not
     infringe a granted patent of a third party in any material respect.

          (iii) Neither Roberts nor any of its Subsidiaries has any license or
     other rights with respect to any Intellectual Property owned by any other
     person or entity.

          (iv) All technology, processes, techniques and methods of manufacture
     used in or necessary to the manufacturing or research operations of Roberts
     and its Subsidiaries, except to the extent the same are in the public
     domain, are subject to valid and effective confidentiality agreements
     between Roberts and its employees, have been memorialized to the extent
     required by good manufacturing practice and, to the knowledge of Roberts,
     are the subject



<PAGE>
                                      -28-


     of no claim, whether or not asserted, that their use or employment by
     Roberts or any of its Subsidiaries violates the rights of any person.

          (t) Insurance. Section 3.1(t) of the Roberts Disclosure Schedule sets
     forth (i) a complete and accurate list of all policies of insurance of
     Roberts and its Subsidiaries currently in force, including surety bonds or
     other credit support therefor (the "Roberts Insurance Policies"), the
     current annual premiums for each Roberts Insurance Policy, the types of
     risk covered and limits of coverage and (ii) a description of claims
     experience of Roberts (x) in the twelve months immediately preceding the
     date hereof with respect to all matters and (y) since its incorporation
     with respect to product liability matters, matters arising by reason of
     clinical trials, environmental matters and workmen's compensation. All
     Roberts Insurance Policies are in full force and effect and all premiums
     due thereon have been paid. Roberts has complied in all material respects
     with the terms and provisions of the Roberts Insurance Policies. Roberts
     has never applied for and been refused or denied any policy of insurance
     with respect to product liability matters, matters arising by reason of
     clinical trials, environmental matters and workmen's compensation. Roberts'
     insurance coverage is adequate in kind and amount based on current industry
     practice.

          (u) Books and Records. (i) The books of account and other financial
     records of Roberts and its Subsidiaries that have been made available to
     Shire prior to the date hereof or are made available thereafter are or will
     be true, complete and correct in all material respects and do not and will
     not contain any omissions which, in light of the circumstances in which
     they are made, are materially misleading.

          (ii) The minute books and other records of Roberts and its
     Subsidiaries that have been made available to Shire prior to the date
     hereof or are made available thereafter contain records of all meetings of
     Roberts and its Subsidiaries prior to the date hereof and prior to the
     Effective Time, respectively, are or will be accurate in all material
     respects and reflect accurately in all material respects all other
     corporate action of the shareholders and directors and any committees of
     the Board of Directors of Roberts and its Subsidiaries.




<PAGE>
                                      -29-


          (v) Undisclosed Liabilities. Except as set forth in the Filed SEC
     Documents and except for liabilities and obligations incurred in the
     ordinary course of business consistent with past practice and U.S. GAAP,
     neither Roberts nor any of its Subsidiaries has any liabilities or
     obligations of any nature (whether accrued, absolute, contingent or
     otherwise) required by US GAAP to be set forth on a consolidated balance
     sheet of Roberts and its consolidated Subsidiaries or in the notes thereto
     and which, individually or in the aggregate, could reasonably be expected
     to have a Roberts Material Adverse Effect.

          (w) FDA, DEA Matters. Section 3.1(w) of the Roberts Disclosure
     Schedule sets forth a complete and accurate list of (i) each
     investigational new drug filing made by Roberts or any of its Subsidiaries
     with the U.S. Food and Drug Administration (the "FDA") or any non-U.S.
     equivalent (including, without limitation, the U.K. Medicines Control
     Agency (the "MCA") and Health Protection Branch of the Ministry of Health
     of Canada), (ii) each clinical trial protocol submitted by Roberts or any
     of its Subsidiaries to the FDA or any non-U.S. equivalents, (iii) each new
     drug application and abbreviated or supplemental new drug application filed
     by Roberts or any of its Subsidiaries pursuant to the Federal Food, Drug
     and Cosmetic Act, as amended, or any non-U.S. equivalents, (iv) each
     product license application filed by Roberts or any of its Subsidiaries
     pursuant to the Public Health Service Act, as amended, or any non-U.S.
     equivalents and (v) each establishment license application filed with
     respect to any product of Roberts or any of its Subsidiaries under the
     Public Health Service Act, as amended, or any non-U.S. equivalents. (i)
     There are no lawsuits, arbitrations, legal or administrative or regulatory
     proceedings, charges, complaints or investigations by the FDA, the U.S.
     Drug Enforcement Agency (the "DEA"), the U.S. Department of Justice (the
     "DOJ") or any state or non-U.S. regulatory agency pending or, to the best
     knowledge of Roberts, threatened against or relating to Roberts, any of its
     Subsidiaries or any of their products, (ii) there have been no product
     recalls or similar actions by Roberts or any of its Subsidiaries, (iii)
     each clinical trial with respect to products of Roberts and its
     Subsidiaries has been conducted in accordance with its clinical trial
     protocol and applicable regulations and Roberts or one of its Subsidiaries
     has filed all required notices (and made available to Shire copies thereof)
     of adverse drug experiences, injuries or deaths relating to clinical trials
     of such prod-




<PAGE>
                                      -30-


     ucts, and Roberts or one of its Subsidiaries has filed all required notices
     of any such occurrence, (iv) to the best knowledge of Roberts, all clinical
     trials have been and are being conducted in substantial compliance with all
     applicable good clinical practice regulations, (v) neither Roberts nor any
     of its Subsidiaries nor, to the best knowledge of Roberts, any of their
     respective officers, employees or agents has made an untrue statement of
     material fact or fraudulent statement to the FDA, the MCA, the DEA or other
     regulatory agencies, failed to disclose a material fact required to be
     disclosed to any of them or committed an act, made a statement or failed to
     make a statement that could reasonably be expected to provide a basis for
     any of them to invoke the policy respecting "Fraud, Untrue Statements of
     Material Facts, Bribery and Illegal Gratuities" set forth in 56 Fed. Reg.
     46191 (September 10, 1991) or equivalent regulations, (vi) there are no
     unresolved reports, warning letters or other documents received from or
     issued by the FDA, the MCA, the DEA or other regulating agencies that
     indicate or suggest material lack of compliance with applicable regulatory
     requirements by Roberts, any of its Subsidiaries or persons providing
     services for the benefit of any of them, (vii) to the best knowledge of
     Roberts, no person has filed a claim for loss or potential loss under any
     indemnity covering participants in clinical trials of products of Roberts
     and its Subsidiaries, (viii) to Roberts' knowledge, no material
     modifications to the process by which products of Roberts or any of its
     Subsidiaries that have been or are being used in clinical trials are
     manufactured will be necessary in order to manufacture commercial
     quantities of such products, (ix) as to each drug of Roberts or any of its
     Subsidiaries for which a new drug application or abbreviated new drug
     application has been approved by the FDA or other regulating agencies, the
     applicant and all persons performing operations covered by the application
     are in substantial compliance with 21 U.S.C. Section 355 or 357, 21 C.F.R.
     Part 314 or 430 et seq. (or non-U.S. equivalents), respectively, and all
     terms and conditions of the application, (x) Roberts and its Subsidiaries
     are in compliance with all applicable registration and listing requirements
     set forth in 21 U.S.C. Section 360 and 21 C.F.R. Part 207 and, to the
     extent required, Roberts or one of its Subsidiaries has obtained licenses
     from the DEA and is in compliance with all such licenses and all applicable
     regulations promulgated by the DEA, (xi) all manufacturing operations
     conducted by or, to the knowledge of Roberts, for the benefit of Roberts
     and its Subsidiaries




<PAGE>
                                      -31-


     have been and are being conducted in compliance with applicable good
     manufacturing practice regulations including those set forth in 21 C.F.R.
     Parts 210 and 211, (xii) neither Roberts nor any of its Subsidiaries has
     received any written notice that the FDA, the MCA, the DEA or other
     regulating agencies has commenced, or threatened to initiate, any action to
     withdraw its approval or request the recall of any product of Roberts or
     its Subsidiaries or withdraw advertising or sales promotion materials or
     commenced, or threatened to initiate, any action to enjoin production at
     any facility owned or used by Roberts or any of its Subsidiaries or any of
     their manufacturing locations, (xiii) as to each article of drug or
     consumer product currently manufactured and/or distributed by or on behalf
     of Roberts or its Subsidiaries, such article is not adulterated or
     misbranded within the meaning of the FDCA, 21 U.S.C. Sections 301 et seq.,
     and all advertising and sales promotional materials of Roberts or its
     Subsidiaries are otherwise in conformance with applicable regulations and
     (xiv) neither Roberts nor any of its Subsidiaries nor, to the knowledge of
     Roberts, any of their respective officers, employees, agents or affiliates
     has been convicted of any crime or engaged in any conduct for which
     debarment is mandated by 21 U.S.C. Section 335(a) or authorized by 21
     U.S.C. Section 335a(b). To the knowledge of Roberts, Roberts' contractors
     are in compliance with all applicable law and regulations and in respect of
     the FDA and DEA have secured all licenses, renewals and quotas necessary to
     their operation.

          Roberts has made available to Shire copies of all written
     communications to or from the FDA and the DEA relating specifically to
     Roberts, its Subsidiaries and their respective operations or business.

          (x) Environmental Matters. (i) Each of Roberts and its Subsidiaries
     possesses all Environmental Permits required under applicable Environmental
     Laws to conduct its business as currently conducted and to own and operate
     its assets, and is in compliance in all material respects with the terms
     and conditions of such Environmental Permits.

          (ii) The execution, delivery and performance of this Agreement and the
     consummation of the transactions contemplated hereby will not affect the
     validity or require the transfer of any Environmental Permits held by
     Roberts or its Subsidiaries, and will not require any notification,





<PAGE>
                                      -32-


     disclosure, registration, reporting, filing, investigation or remediation
     under any Environmental Law.

          (iii) Each of Roberts and its Subsidiaries is in compliance in all
     material respects with all applicable Environmental Laws and has no
     material liability under any Environmental Law.

          (iv) There is no civil, criminal or administrative action, suit,
     demand, claim, hearing, notice of violation, proceeding, notice or demand
     letter, or request for information pending or, to the knowledge of Roberts
     threatened, under any Environmental Law (x) against Roberts or its
     Subsidiaries or (y) to the knowledge of Roberts against any person or
     entity in connection with which liability could reasonably be expected to
     be imputed or attributed by law or contract to Roberts or its Subsidiaries.

          (v) No property or facility presently or formerly owned, leased or
     operated by Roberts or its Subsidiaries, and no property or facility at
     which Hazardous Materials of Roberts or its Subsidiaries have been stored,
     treated or disposed of or at which any Hazardous Materials have been
     manufactured, handled, tested, formulated, prepared, encapsulated,
     packaged, bottled or stored for Roberts or its Subsidiaries ("Roberts
     Product Sites") is listed or proposed for listing on the National
     Priorities List or the Comprehensive Environmental Response, Compensation
     and Liability Information System, both promulgated under the Comprehensive
     Environmental Response, Compensation and Liability Act of 1980, as amended
     ("CERCLA"), or on any comparable list established under any Environmental
     Law.

          (vi) There has been no disposal, spill, discharge, emission or release
     of any Hazardous Material by Roberts or its Subsidiaries on, at, under or
     from any property presently or formerly owned, leased or operated by
     Roberts or its Subsidiaries and there are no Hazardous Materials located
     in, at, on or under any such facility or property, or, to the knowledge of
     Roberts, at any Roberts Product Site or other location where Hazardous
     Materials of Roberts or any of its Subsidiaries have been stored, treated
     or disposed of (a "Roberts Third Party Site"), in each case that could
     reasonably be expected to result in the incurrence of any material
     liability, by Roberts or its Subsidiaries under any Environmental Law.




<PAGE>
                                      -33-


          (vii) There are no underground storage tanks or other underground
     storage receptacles or related piping, or any impoundments containing
     Hazardous Materials located on any facility or property owned, leased or
     operated by Roberts or any of its Subsidiaries.

          (viii) No Lien has been recorded against any properties, assets or
     facilities owned, leased or operated by Roberts or any of its Subsidiaries
     under any Environmental Law.

          (ix) Neither Roberts nor any of its Subsidiaries is obligated to
     perform any investigation or other action under any Environmental Law
     pursuant to any order, decree, judgment or agreement by which it is bound,
     or has assumed by contract or agreement any obligation or liability under
     any Environmental Law.

          Roberts has made available to Shire all material records and files,
     including, but not limited to, all assessments, reports, studies, audits,
     analyses, tests and data, in possession, custody or control of Roberts or
     its Subsidiaries concerning compliance by Roberts and its Subsidiaries
     with, or liability under, any Environmental Law, including, without
     limitation, those concerning the existence of Hazardous Materials at
     facilities or properties currently or formerly owned, operated or leased by
     Roberts or its Subsidiaries or at any Roberts Product Site or Roberts Third
     Party Site.

          (y) Products. Each of the products produced or sold by Roberts and its
     Subsidiaries: (i) is, and at all times up to and including the date hereof
     has been, in compliance in all material respects with all applicable
     federal, state, local and non-U.S. laws and regulations; (ii) is, and at
     all relevant times has been, fit for the ordinary purposes for which it is
     intended to be used and conforms in all material respects to any promises
     or affirmations of fact made on the container, label or promotional
     materials for such product or in connection with its sale; and (iii)
     contains no design or manufacturing defect. Neither Roberts nor any of its
     Subsidiaries has received notice of any product warranty claims. Neither
     Roberts nor any of its Subsidiaries is aware of any facts which are
     reasonably likely to cause (i) the withdrawal or recall of any product sold
     or intended to be sold by Roberts or its Subsidiaries, (ii) a change in the
     marketing classification, labeling or promotional materials of any such
     products, or





<PAGE>
                                      -34-


     (iii) a termination or suspension of marketing of any such products. There
     are no material claims pending or, to the knowledge of Roberts, threatened
     against Roberts or its Subsidiaries with respect to the quality of or
     absence of defects in such products nor are there any facts known to
     Roberts relating to the quality of or absence of defects in such products
     which, if known by a potential claimant or governmental authority, could
     reasonably be expected to give rise to a claim or proceeding. To the
     knowledge of Roberts, no supplier of a raw material required for the
     manufacture of a material product of Roberts and its Subsidiaries for which
     there is not a permissible replacement obtainable under commercially
     reasonable terms has indicated that it will not continue to supply such raw
     material on terms consistent with those on the date hereof.

          (z) Marketing Practices. Roberts' operations and commercial conduct
     and those of its Subsidiaries have at all times conformed in all material
     respects to the Code of Marketing Practices of the Pharmaceutical Research
     Industry Association.

          (aa) Affiliates. Roberts has delivered to Shire a letter identifying
     all persons who, as of the date hereof, may be deemed to be affiliates of
     Roberts for purposes of Rule 145 under the Securities Act ("Affiliates")
     and the written agreement of each such person in the form of Exhibit 3
     hereto.

          (bb) Pooling. Neither Roberts nor any of its Affiliates has taken or
     agreed to take any action or failed to take any action that would prevent
     the Merger from being treated for financial accounting purposes as a
     "pooling of interests" in accordance with US GAAP and the regulations and
     interpretations of the SEC.

          (cc) Business Combination. Neither the execution and delivery of this
     Agreement, the Option Agreement, the Shareholder Agreements nor the
     consummation of the transactions contemplated hereby or thereby, as the
     case may be, will (i) violate the Shareholder Protection Act or (ii) cause,
     directly or indirectly, a Triggering Event, as that term is defined in the
     Rights Agreement.

     3.2. Representations and Warranties of Shire. Shire represents and warrants
to Roberts that, except (A) as set forth in the Shire Disclosure Schedule
delivered by Shire to Roberts at or prior to the execution of this Agreement
(the




<PAGE>
                                      -35-


"Shire Disclosure Schedule") (each section of which qualifies the
correspondingly numbered representation and warranty), and (B) with respect to
paragraphs (j), (m), (o), (p), (q), (r), (t), (w), (x) and (y) of this Section
3.2, as does not have, or could not reasonably be expected to have, individually
or in the aggregate, a Shire Material Adverse Effect, the following is true and
correct:

          (a) Organization; Standing and Power. Shire is a corporation duly
     organized and validly existing under the laws of the United Kingdom. Shire
     has all requisite corporate power and authority to own, lease and operate
     its assets and to carry on its business as now being conducted. Shire is
     duly qualified as a foreign corporation to do business in each jurisdiction
     where the character of its assets owned or leased or the nature of its
     activities makes such qualification necessary (such jurisdictions being
     specified in Section 3.2(a) of the Shire Disclosure Schedule) except where
     the failure to be so qualified would not have a Shire Material Adverse
     Effect. Copies of the Memorandum and Articles of Association of Shire as in
     effect on the date hereof have been previously delivered to Roberts.
     Acquisition Sub is a corporation duly organized, validly existing and in
     good standing under the laws of the State of New Jersey. Acquisition Sub
     has not conducted any activities other than in connection with its
     organization, the negotiation and execution of this Agreement and the
     consummation of the transactions contemplated hereby.

          (b) Subsidiaries and Investments. Section 3.2(b) of the Shire
     Disclosure Schedule lists each Subsidiary of Shire. Each such Subsidiary is
     a corporation duly organized, validly existing and (in applicable
     jurisdictions) in good standing under the laws of its jurisdiction of
     incorporation. Each such Subsidiary has all requisite corporate power and
     authority to own, lease and operate its assets and to carry on its business
     as now being conducted. All such Subsidiaries are duly qualified as foreign
     corporations to do business, and (in applicable jurisdictions) are in good
     standing, in each jurisdiction where the character of their respective
     assets owned or leased or the nature of their respective activities makes
     such qualification necessary, except where the failure to be so qualified
     or in good standing would not have a Shire Material Adverse Effect. All the
     outstanding shares of capital stock of each such Subsidiary have been
     validly issued and are fully paid (and in applicable jurisdic-




<PAGE>
                                      -36-


     tions, nonassessable) and are owned by Shire, by another Subsidiary of
     Shire or by Shire and another such Subsidiary, free and clear of all Liens,
     other than Liens which (individually or in the aggregate) would not have a
     Shire Material Adverse Effect. Except for the capital stock of its
     Subsidiaries, Shire does not own any stock, partnership or other equity
     interest in, or any debt or equity securities of, any person or entity.

          (c) Capitalization. The authorized share capital of Shire as of the
     date of this Agreement is (pound)10,000,000 divided into 200,000,000
     Ordinary Shares. At the close of business on July 20, 1999 (i) 143,509,230
     Ordinary Shares were issued and (ii) the board of directors of Shire were
     generally and unconditionally authorized to allot relevant securities up to
     a nominal amount of (pound)2,361,070 and no other share capital was issued
     or reserved for issuance. All such Ordinary Shares of Shire are, and all
     Ordinary Shares reserved for issuance will be, when issued, duly
     authorized, validly issued and fully paid and not subject to preemptive
     rights other than as required by law or the LSE rules. The Ordinary Shares
     to be issued in the Merger will not be subject to preemption from existing
     shareholders of Shire. Except as set forth above, as of the date of this
     Agreement, there are not any Equity Equivalents of any of Shire or any of
     its Subsidiaries (including, without limitation, any option, warrant, right
     to subscribe, call or commitment of any kind or character whatsoever
     requiring the issuance, sale or transfer by Shire or any of its
     Subsidiaries of any shares of their capital stock or any securities
     convertible into or exchangeable or exercisable for such capital stock). As
     of the date of this Agreement, there are not any outstanding contractual
     obligations of Shire or any of its Subsidiaries to repurchase, redeem or
     otherwise acquire any shares of capital stock of Shire or any of its
     Subsidiaries. There are no outstanding SARs with respect to Shire. Shire
     has delivered to Roberts a complete list of all outstanding indebtedness of
     Shire and its Subsidiaries.

          (d) Authority. Each of Shire and Acquisition Sub has the requisite
     corporate power and authority to execute and deliver this Agreement and,
     subject to Shire Shareholder Approval (as defined below), to perform its
     respective obligations hereunder. The execution and delivery of this
     Agreement by each of Shire and Acquisition Sub and the consummation of the
     transactions contemplated hereby have been duly authorized by the Board of
     Directors, or a




<PAGE>
                                      -37-


     duly authorized committee thereof, of each of Shire and Acquisition Sub. No
     other corporate proceedings on the part of Shire (other than the approval
     of this Agreement and the transactions contemplated hereby by the holders
     of not less than a majority of the Ordinary Shares present and voting or on
     a poll (the "Shire Shareholder Approval")) or Acquisition Sub are necessary
     to authorize the performance of this Agreement and the consummation of the
     transactions contemplated hereby. This Agreement has been duly executed and
     delivered by each of Shire and Acquisition Sub, and constitutes a valid and
     binding obligation of each of Shire and Acquisition Sub, enforceable in
     accordance with its terms, subject to applicable bankruptcy, insolvency,
     moratorium or other similar laws relating to creditors' rights and general
     principles of equity.

          (e) Noncontravention. Neither the execution and delivery of this
     Agreement by Shire or Acquisition Sub nor the consummation of the
     transactions contemplated hereby nor compliance by Shire or Acquisition Sub
     with any of the provisions hereof will (i) violate, conflict with or result
     in a breach of any provision of, or constitute a default (or an event
     which, with notice or lapse of time or both, could constitute a default)
     under, or result in the termination, modification or suspension of, or
     accelerate the performance required by, or result in a right of termination
     or acceleration under, or result in the creation of any Lien upon, right to
     acquire or obligation to dispose of any of the properties, assets or rights
     of Shire or any of its Subsidiaries under, any of the terms, conditions or
     provisions of (x) the Memorandum and Articles of Association of Shire or
     equivalent charter documents of any of its Subsidiaries or (y) any note,
     bond, mortgage, credit agreement, indenture, deed of trust, license,
     Permit, authorization, lease, agreement or instrument or obligation to
     which Shire or any of its Subsidiaries is party or by which they are bound
     or to which they or any of their assets may be subject, or (ii) violate any
     judgment, ruling, order, writ, injunction, decree, statute, rule or
     regulation applicable to Shire or any of its Subsidiaries, their operations
     or any of their assets, except for such violations, conflicts or breaches
     referred to in clauses (i)(y) and (ii) which would not, individually or in
     the aggregate, have a Shire Material Adverse Effect.

          (f) Government Approval; Consents. No consents and approvals are
     required to be obtained by Shire or Acquisi-




<PAGE>
                                      -38-


     tion Sub from non-governmental third parties ("Shire Third Party
     Approvals") in order to lawfully and contractually permit it to perform its
     obligations under this Agreement and consummate the transactions
     contemplated hereby. No notice to, filing with, or authorization, consent
     or approval of, any U.K. or non-U.K. public body or authority is necessary
     for the execution, delivery or performance of this Agreement by Shire or
     Acquisition Sub or the consummation of the transactions contemplated hereby
     ("Shire Governmental Approvals").

          (g) Reports and Financial Statements. (i) Shire has delivered to
     Roberts (A) its annual report for its fiscal year ended December 31, 1998,
     (B) all documents distributed to Shire's shareholders relating to meetings
     of the shareholders of Shire since January 1, 1998, and (C) all of its
     other reports and statements distributed to Shire shareholders together
     with copies of all prospectuses and listing particulars issued by Shire or
     any of its Subsidiaries since January 1, 1998 (the "Shire Documents"). As
     of the date of its distribution to shareholders, each such report or
     statement distributed to shareholders did not contain any untrue statement
     of material fact or omit a material fact required to be stated therein or
     necessary to make the statements therein, in the light of the circumstances
     under which they were made, not misleading. The audited consolidated
     financial statements of Shire included in the Shire Documents were prepared
     in accordance with accounting principles generally accepted in the United
     Kingdom ("UK GAAP") (except in the case of unaudited statements) applied on
     a consistent basis during the periods involved (except as may be indicated
     in the notes thereto), and present a true and fair view of the consolidated
     financial position of Shire and its consolidated Subsidiaries as of the
     dates of approval of such financial statements by the board of directors of
     Shire and the consolidated results of their operations and cash flows for
     the periods set forth therein.

          (h) Information Supplied. None of the information supplied or to be
     supplied by Shire for inclusion or incorporation by reference in (i) the
     Form F-4 will, at the time the Form F-4 is filed with the SEC, at any time
     it is amended or supplemented or at the time it becomes effective under the
     Securities Act, contain any untrue statement of a material fact or omit to
     state any material fact required to be stated therein or necessary to make
     the statements therein not misleading, (ii) the UK Disclosure



<PAGE>
                                      -39-


     Documents will, on the date the UK Disclosure Documents are first mailed to
     the shareholders of Shire, or at the time of the Shire shareholders meeting
     contain any untrue statement of a material fact or omit to state any
     material fact required to be stated therein or necessary in order to make
     the statements therein, in the light of the circumstances under which they
     are made, not misleading or (iii) the Proxy Statement will, at the date it
     is first mailed to Roberts shareholders or at the time of the Roberts
     Shareholders Meeting contain any untrue statement of a material fact or
     omit to state any material fact required to be stated therein or necessary
     in order to make the statements therein, in the light of the circumstances
     under which they are made, not misleading. The UK Disclosure Documents will
     contain all particulars relating to Shire and Roberts required to comply in
     all material respects with all United Kingdom statutory and other legal
     provisions (including, without limitation, the Companies Act, the FSA and
     the rules and regulations made thereunder and the rules and requirements of
     the LSE) and all such information contained in such documents will be
     substantially in accordance with the facts and will not omit anything
     material likely to affect the import of such information. The Form F-4 will
     comply as to form in all material respects with the requirements of the
     Securities Act and the rules and regulations thereunder, except that no
     representation is made by Shire with respect to statements made or
     incorporated by reference therein based on information supplied by Roberts.

          (i) Absence of Certain Changes or Events. Except as disclosed in the
     Shire Documents filed and publicly available, or as disclosed in
     announcements made by Shire in compliance with the continuing obligations
     of the LSE prior to the date of this Agreement (the "Public UK Documents"),
     since December 31, 1998 there has not been (i) any material adverse change
     in the business, assets, financial condition or results of operations of
     Shire and its Subsidiaries, taken as a whole, (ii) any destruction or loss
     of (whether or not covered by insurance) any property, asset or right that
     has had or is likely to have a Shire Material Adverse Effect, (iii) any
     authorization or issuance by Shire of any of its capital stock or the
     issuance of any debt security or other evidence of Indebtedness of Shire or
     any of its Subsidiaries, (iv) any redemption or other acquisition by Shire
     of any of its capital stock or by Shire or any of its Subsidiaries of any
     debt securities or other evidences of Indebtedness, or any pay-




<PAGE>
                                      -40-


     ment made with respect to any of the foregoing (other than any regular,
     periodic payment of interest made with respect to a debt security or other
     evidence of Indebtedness), (v) any declaration, setting aside or payment of
     any dividend or other distribution or payment (whether in cash, capital
     stock or otherwise) in respect of any capital stock of Shire, (vi) any
     disposal or lapse of any Shire Intellectual Property or Shire Intellectual
     Property License, (vii) any Lien (other than a Permitted Lien) incurred on
     any material property, assets or rights of Shire or any of its
     Subsidiaries, (viii) any incurrence by Shire or any of its Subsidiaries of
     any liability which has had or is likely to have a Shire Material Adverse
     Effect, (ix) any incurrence of Indebtedness or any guarantee by Shire or
     any of its Subsidiaries of any liability of any other person or entity
     outside of the ordinary course of business, (x) to the knowledge of Shire,
     any development with respect to regulatory approval of any products of
     Shire or any of its Subsidiaries which has had or is likely to have a Shire
     Material Adverse Effect, (xi) to the knowledge of Shire, any development
     with respect to relationships with any contract manufacturer or contract
     research organization with which Shire or any of its Subsidiaries has a
     business relationship which has had or is likely to have a Shire Material
     Adverse Effect or (xii) any change in Shire's Tax accounting methods, any
     new election made with respect to Taxes, any modification or revocation of
     any existing election made with respect to Taxes, or any settlement or
     other disposition of any Tax matter.

          (j) Compliance with Law. Neither Shire nor any of its Subsidiaries is
     in violation or non-compliance in any material respect with any statute,
     law, ordinance, regulation, rule, order or other legal requirement of any
     government, authority or any other governmental department or agency
     applicable to its business or operations, or any judgment, decree or order
     of any court to which it is a party.

          (k) Affiliate Arrangements. Neither Shire nor any of its Subsidiaries
     is a party to any contract, agreement, arrangement, understanding or other
     commitment with any director, officer or securityholder of Shire or any of
     its Subsidiaries or, to the knowledge of Shire, any person or entity
     controlled by any such person.

          (l) Transaction Fees. Shire has not retained any broker, finder,
     financial adviser, investment banker or




<PAGE>
                                      -41-


     other person or entity which is entitled to any brokerage, finder's or
     similar fee or commission in connection with this Agreement or the
     transactions contemplated hereby.

          (m) Litigation. There is no claim, action, suit or proceeding pending
     or, to the knowledge of Shire, threatened against Shire or any of its
     Subsidiaries or any of their respective properties, assets or rights before
     any court or governmental or regulatory authority or body.

          (n) Taxes and Tax Returns. (i) Shire has duly and timely filed all
     U.K. and non-U.K. Tax Returns required to be filed by it and its
     Subsidiaries, and each such Tax Return is complete and accurate in all
     material respects, (ii) Shire has timely paid all Taxes due and payable by
     it and its Subsidiaries and has made adequate provision (through a current
     accrual on its most recent financial statements) for any Taxes that are not
     yet due and payable and (iii) Shire has withheld and paid in a timely
     manner all Taxes required to have been withheld and paid in connection with
     amounts paid or owing to any employee, independent contractor, creditor,
     stockholder or other third party, including amounts of or the value of
     awards and prizes paid to Shire's employees. Any deficiencies or
     assessments asserted in writing by any taxing authority have been paid or
     fully settled and no issue raised by any such taxing authority reasonably
     could be expected to result in a proposed deficiency for any prior,
     parallel or subsequent period (including periods subsequent to the
     Effective Time). There are no claims or assessments pending (or, to the
     best knowledge of Shire, threatened) against Shire or any of its
     Subsidiaries for any alleged U.K. or non-U.K. Tax deficiency and no issue
     has been raised in writing by any U.K. or non-U.K. taxing authority or
     representative thereof. No claim has ever been made by an authority in a
     jurisdiction where Shire does not file Tax Returns that it is or may be
     subject to taxation by that jurisdiction. Section 3.2(n) of the Shire
     Disclosure Schedule lists all U.K. and non-U.K. jurisdictions in which
     Shire files Tax Returns, and indicates those Tax Returns that have been
     audited and those that currently are the subject of audit. Shire has not
     consented to an extension of the statute of limitations with respect to any
     Tax period. Shire is not a party to any Tax allocation or sharing
     agreement. Shire (i) has never been a member of any combined, consolidated,
     affiliated or unitary group for any U.K. or non-U.K. Tax purposes and (ii)
     has no liability for the Taxes of any person as a transferee or



<PAGE>
                                      -42-


     successor, by contract, or otherwise. Shire has never requested a ruling
     from, or entered into a closing agreement with any taxing authority. Shire
     has previously delivered to Roberts true and complete copies of (i) all
     U.K. and non-U.K. income or franchise Tax Returns for each of the last
     three taxable years ending prior to the date of this Agreement (except for
     those Tax Returns that have not yet been filed) and (ii) any audit reports
     issued within the last three years by any taxing authority.

          (o) Real Property. Section 3.2(o) of the Shire Disclosure Schedule
     sets forth a complete and accurate list of all material real property owned
     or leased by Shire or any of its Subsidiaries, including (i) with respect
     to owned real property, the date of its acquisition, any Liens on or with
     respect to such real property (other than Permitted Liens), the name of the
     holder of any such Lien and the amount and nature of any obligation secured
     by any such Lien and (ii) with respect to leased real property, the name of
     the lessor of such real property, a list of all instruments and documents
     governing the terms of such leasehold interest, any Lien on or with respect
     to such leasehold interest (other than Permitted Liens), the name of the
     holder of any such Lien and the amount and nature of any obligation secured
     by any such Lien. Shire is not a lessor with respect to any material real
     property owned by it or any of its Subsidiaries and has not granted any
     sublease of any leasehold interest in any material real property leased by
     it or any of its Subsidiaries. With respect to such material real property,
     (i) there are no eminent domain proceedings pending or threatened against
     it, (ii) such properties and the improvements thereon (including the roof
     and structural portions of each building) are in good operating order and
     condition, subject to ordinary wear and tear, and (iii) the use thereof
     does not violate any zoning or similar land use laws or other government
     regulations other than such violations which, individually or in the
     aggregate, would not adversely affect the ability of Shire and its
     Subsidiaries to use, operate or occupy any of such properties following the
     Effective Time. The real property owned or leased by Shire and its
     Subsidiaries is sufficient for the conduct of their business.

          (p) Licenses, Permits and Authorizations. Section 3.2(p) of the Shire
     Disclosure Schedule sets forth a complete and accurate list of all material
     Permits held by or on behalf of Shire and its Subsidiaries, including (i)
     the




<PAGE>
                                      -43-


     agency or body issuing such Permit, (ii) the person or entity to whom such
     Permit was issued and (iii) the date such Permit expires or is required to
     be renewed. Each such Permit is, to the knowledge of Shire, in full force
     and effect and Shire, or the person or entity who holds such Permit on
     Shire's behalf, is in compliance in all material respects with all of its
     obligations with respect thereto, and, to the knowledge of Shire, no event
     has occurred or condition exists which permits or, upon the giving of
     notice or lapse of time or both, would permit revocation, nonrenewal,
     modification, suspension or termination of any such Permit.

          (q) ERISA and Employee Matters. Section 3.2(q) of the Shire Disclosure
     Schedule sets forth a complete and accurate list of all employment and
     consultancy agreements, all employee benefit plans (within the meaning of
     Section 3(3) of ERISA) or retirement benefits scheme (within the meaning of
     Section 611 of the Income and Corporation Taxes Act 1988) and all other
     written plans, arrangements or policies relating to stock options, stock
     purchases, compensation, deferred compensation, supplemental retirement
     arrangements, other incentive programs, severance, fringe benefits or other
     employee benefits (collectively "Shire Employment Obligations") covering
     all present and former officers, directors, employees, consultants and
     agents of Shire and its Subsidiaries and any of their spouses or
     dependents. Shire has made available to Roberts true, complete and correct
     copies of (i) each Shire Employment Obligation, (ii) the most recent annual
     report on Form 5500 as filed with the Internal Revenue Service with respect
     to each applicable Shire Employment Obligation, (iii) the most recent
     summary plan description (or similar document) with respect to each
     applicable Shire Employment Obligation, (iv) each trust agreement and
     insurance or annuity contract relating to any Shire Employment Obligation
     and (v) the most recent actuarial valuation report for each applicable
     Shire Employment Obligation. With respect to all Shire Employment
     Obligations benefiting Shire's U.S. employees, (i) Shire and its
     Subsidiaries are in compliance in all material respects with all applicable
     provisions of ERISA and the Code with respect to each Shire Employment
     Obligation, (ii) except for PBGC premiums, all of which that are due have
     been paid, neither Shire nor any of its Subsidiaries has any material
     liability under Title IV of ERISA, (iii) neither Shire nor any of its
     Subsidiaries has engaged in a prohibited transaction or breach of fiduciary
     duty that would






<PAGE>
                                      -44-


     subject it to a material tax imposed under Section 4975 of the Code or
     material liability pursuant to Section 409 or 502 of ERISA, (iv) neither
     Shire nor any of its Subsidiaries has been a party to or contributed to any
     "multiemployer plan" as defined in Section 4001(a) of ERISA, (v) no pension
     plan covering any present or former officers, directors or employees of
     Shire or any of its Subsidiaries is or has been subject to Title IV of
     ERISA, (vi) except for liability for contributions and benefits pursuant to
     such Shire Employment Obligations, neither Shire nor any of its
     Subsidiaries has incurred any material liability under or pursuant to Title
     I or IV of ERISA or the penalty, excise tax or joint and several liability
     provisions of the Code relating to employee benefit plans and (vii) except
     claims for benefits payable in the normal operation of such Shire
     Employment Obligations, there are no investigations by any governmental
     agency, termination proceedings or other claims, suits or proceedings
     against or involving any such Shire Employment Obligation or asserting any
     rights to or claims for benefits under any such Shire Employment
     Obligation. In respect of any Shire Employment Obligations benefiting Shire
     UK employees, (i) the only benefits provided are defined contribution
     benefits and no promise, assurance or undertaking has been given to any of
     the employees (whether legally binding or not) as to the provision of
     retirement, death or disability benefits at a particular level and (ii)
     there are not in respect of any retirement benefits scheme or the benefits
     under it any actions, suits or claims pending or threatened (other than
     routine claims or benefits) against the trustees or administrators of that
     scheme or against Shire. Each Shire Employment Obligation of Shire and its
     Subsidiaries (if any) that is intended to be a tax-qualified plan has been
     the subject of a determination letter from the Internal Revenue Service to
     the effect that such Shire Employment Obligation and each related trust is
     qualified and exempt from Federal income taxes under Sections 401(a) and
     501(a), as applicable, respectively, of the Code, no such determination
     letter has been revoked, and revocation has not been threatened and no
     event has occurred and no circumstances exist that would reasonably be
     expected to adversely affect the tax qualification of such Shire Employment
     Obligation. Each of the Shire Employment Obligations with respect to
     employees or former employees employed by Shire or any of its Subsidiaries
     outside of the United States are in compliance in all material respects
     with all applicable law (including, where applicable, Article 141 of the
     Treaty of Rome) and,




<PAGE>
                                      -45-


     to the extent the benefits provided thereunder are not mandated by the laws
     of the applicable jurisdiction, copies of the applicable written plan
     document have been made available to Roberts.

          (r) Labor Relations. (i) There is no unfair labor practice complaint
     pending against Shire or any of its Subsidiaries or, to the knowledge of
     Shire, threatened against them before the National Labor Relations Board or
     any other U.S. or non-U.S. governmental or regulatory authority, and, to
     the knowledge of Shire, no grievance or arbitration proceeding arising out
     of or under any of their Shire Employment Obligations is so pending against
     Shire or any of its Subsidiaries or threatened against them; (ii) to the
     knowledge of Shire, there is no basis for an unfair labor practice finding
     against Shire or any of its Subsidiaries; (iii) no strike, labor dispute,
     slowdown or stoppage is pending or, to the knowledge of Shire, threatened
     against Shire or any of its Subsidiaries; and (iv) no union has ever
     represented any employee of Shire or any of its Subsidiaries.

          (s) Intellectual Property Rights. (i) Section 3.2(s)(i) of the Shire
     Disclosure Schedule sets forth a complete and accurate list (including
     registration numbers and dates of filing, renewal and termination, where
     applicable, for each jurisdiction where filed) of all Intellectual Property
     owned by Shire and its Subsidiaries which is material to Shire and its
     Subsidiaries, taken as a whole ("Shire Intellectual Property"), including
     any Liens thereon, the name of the holder of any such Lien and the amount
     and nature of any obligation secured by any such Lien. All Shire
     Intellectual Property is owned by Shire or its Subsidiaries free and clear
     of all Liens, no Shire Intellectual Property has been canceled, abandoned
     or otherwise terminated and all patent applications, trademark applications
     and copyright applications included in Shire Intellectual Property have
     been duly filed and are recorded on the public record in the name of Shire
     or one of its Subsidiaries and all renewal fees have been duly paid other
     than where such action would not have a Shire Material Adverse Effect.
     Neither Shire nor any of its Subsidiaries has granted any license or other
     rights with respect to any Shire Intellectual Property to any other person
     or entity.

          (ii) Shire has no knowledge that any of its or its Subsidiaries'
     granted patents are invalid; to the knowl-




<PAGE>
                                      -46-


     edge of Shire, no Shire Intellectual Property is being infringed by any
     third party in any material respect; and, to the knowledge of Shire, its
     current operations do not infringe a granted patent of a third party in any
     material respect.

          (iii) Neither Shire nor any of its Subsidiaries has any license or
     other rights with respect to any Intellectual Property owned by any other
     person or entity.

          (iv) All technology, processes, techniques and methods of manufacture
     used in or necessary to the manufacturing or research operations of Shire
     and its Subsidiaries, except to the extent the same are in the public
     domain, are subject to valid and effective confidentiality agreements
     between Shire and its employees, have been memorialized to the extent
     required by good manufacturing practice and, to the knowledge of Shire, are
     the subject of no claim, whether or not asserted, that their use or
     employment by Shire or any of its Subsidiaries violates the rights of any
     person.

          (t) Insurance. Section 3.2(t) of the Shire Disclosure Schedule sets
     forth (i) a complete and accurate list of all policies of insurance of
     Shire and its Subsidiaries currently in force, including surety bonds or
     other credit support therefor (the "Shire Insurance Policies"), the current
     annual premiums for each Shire Insurance Policy, the types of risk covered
     and limits of coverage and (ii) a description of claims experience of Shire
     (x) in the twelve months immediately preceding the date hereof with respect
     to all matters and (y) since its incorporation with respect to product
     liability matters, matters arising by reason of clinical trials,
     environmental matters and workmen's compensation. All Shire Insurance
     Policies are in full force and effect and all premiums due thereon have
     been paid. Shire has complied in all material respects with the terms and
     provisions of the Shire Insurance Policies. Shire has never applied for and
     been refused or denied any policy of insurance with respect to product
     liability matters, matters arising by reason of clinical trials,
     environmental matters and workmen's compensation. Shire's insurance
     coverage is adequate in kind and amount based on current industry practice.

          (u) Books and Records. (i) The books of account and other financial
     records of Shire and its Subsidiaries that have been made available to
     Roberts prior to the date




<PAGE>
                                      -47-


     hereof or are made available thereafter are or will be true, complete and
     correct in all material respects and do not, and will not, contain any
     omissions which, in light of the circumstances in which they are made, are
     materially misleading.

          (ii) The minute books and other records of Shire and its Subsidiaries
     that have been or will be made available to Roberts contain records of all
     meetings of Shire and its Subsidiaries prior to the date hereof and prior
     to the Effective Time, respectively, are or will be accurate in all
     material respects and reflect accurately in all material respects all other
     corporate action of the shareholders and directors and any committees of
     the Board of Directors of Shire and its Subsidiaries.

          (v) Undisclosed Liabilities. Except as set forth in the Public UK
     Documents and except for liabilities and obligations incurred in the
     ordinary course of business consistent with past practice and UK GAAP
     neither Shire nor any of its Subsidiaries has any liabilities or
     obligations of any nature (whether accrued, absolute, contingent or
     otherwise) required by UK GAAP to be set forth on a consolidated balance
     sheet of Shire and its consolidated Subsidiaries or in the notes thereto
     and which, individually or in the aggregate, could reasonably be expected
     to have a Shire Material Adverse Effect.

          (w) FDA, DEA Matters. Section 3.2(w) of the Shire Disclosure Schedule
     sets forth a complete and accurate list of (i) each investigational new
     drug filing made by Shire or any of its Subsidiaries with the FDA or any
     non-U.S. equivalents (including, without limitation, the MCA), (ii) each
     clinical trial protocol submitted by Shire or any of its Subsidiaries to
     the FDA or any non-U.S. equivalents, (iii) each new drug application and
     abbreviated or supplemental new drug application filed by Shire or any of
     its Subsidiaries pursuant to the Federal Food, Drug and Cosmetic Act, as
     amended, or any non-U.S. equivalents (iv) each product license application
     filed by Shire or any of its Subsidiaries pursuant to the Public Health
     Service Act, as amended, or any non-U.S. equivalents and (v) each
     establishment license application filed with respect to any product of
     Shire or any of its Subsidiaries under the Public Health Service Act, as
     amended or any non-U.S. equivalents. (i) There are no lawsuits,
     arbitrations, legal or administrative or regulatory proceedings, charges,
     complaints or investigations by the FDA, the DEA, the DOJ




<PAGE>
                                      -48-


     or any state or non-U.S. regulatory agency pending or, to the best
     knowledge of Shire, threatened against or relating to Shire, any of its
     Subsidiaries or any of their respective products, (ii) there have been no
     product recalls or similar actions by Shire or any of its Subsidiaries,
     (iii) each clinical trial with respect to products of Shire and its
     Subsidiaries has been conducted in accordance with its clinical trial
     protocol and applicable regulations and Shire or one of its Subsidiaries
     has filed all required notices (and made available to Roberts copies
     thereof) of adverse drug experiences, injuries or deaths relating to
     clinical trials of such products, and Shire or one of its Subsidiaries has
     filed all required notices of any such occurrence, (iv) to the best
     knowledge of Shire, all clinical trials have been and are being conducted
     in substantial compliance with all applicable good clinical practice
     regulations, (v) neither Shire nor any of its Subsidiaries nor, to the best
     knowledge of Shire, any of their respective officers, employees or agents
     has made an untrue statement of material fact or fraudulent statement to
     the FDA, the MCA, the DEA or other regulatory agencies, failed to disclose
     a material fact required to be disclosed to any of them or committed an
     act, made a statement or failed to make a statement that could reasonably
     be expected to provide a basis for any of them to invoke the policy
     respecting "Fraud, Untrue Statements of Material Facts, Bribery and Illegal
     Gratuities" set forth in 56 Fed. Reg. 46191 (September 10, 1991) or
     equivalent regulations, (vi) there are no unresolved reports, warning
     letters or other documents received from or issued by the FDA, the MCA, the
     DEA or other regulatory agencies that indicate or suggest material lack of
     compliance with FDA or DEA regulatory requirements by Shire, any of its
     Subsidiaries or persons providing services for the benefit of any of them,
     (vii) to the best knowledge of Shire, no person has filed a claim for loss
     or potential loss under any indemnity covering participants in clinical
     trials of products of Shire and its Subsidiaries, (viii) to Shire's
     knowledge, no material modifications to the process by which products of
     Shire or any of its Subsidiaries that have been or are being used in
     clinical trials are manufactured will be necessary in order to manufacture
     commercial quantities of such products, (ix) as to each drug of Shire or
     one of its Subsidiaries for which a new drug application or abbreviated new
     drug application has been approved by the FDA or other regulatory agencies,
     the applicant and all persons performing operations covered by the
     application are in substantial compliance with 21 U.S.C.




<PAGE>
                                      -49-


     Section 355 or 357, 21 C.F.R. Part 314 or 430 et seq. (or any non-U.S.
     equivalents), respectively, and all terms and conditions of the
     application, (x) Shire and its Subsidiaries are in compliance with all
     applicable registration and listing requirements set forth in 21 U.S.C.
     Section 360 and 21 C.F.R. Part 207 and, to the extent required, Shire and
     its Subsidiaries have obtained licenses from the DEA and are in compliance
     with all such licenses and all applicable regulations promulgated by the
     DEA, (xi) all manufacturing operations conducted by or, to the knowledge of
     Shire, for the benefit of Shire and its Subsidiaries have been and are
     being conducted in compliance with applicable good manufacturing practice
     regulations including those set forth in 21 C.F.R. Parts 210 and 211, (xii)
     neither Shire nor any of its Subsidiaries has received any written notice
     that the FDA, the MCA, the DEA or other regulatory agencies has commenced,
     or threatened to initiate, any action to withdraw its approval or request
     the recall of any product of Shire or its Subsidiaries or withdraw
     advertising or sales promotion materials or commenced, or threatened to
     initiate, any action to enjoin production at any facility owned or used by
     Shire or any of its Subsidiaries or any of their manufacturing locations,
     (xiii) as to each article of drug or consumer product currently
     manufactured and/or distributed by or on behalf of Shire or its
     Subsidiaries, such article is not adulterated or misbranded within the
     meaning of the FDCA, 21 U.S.C. Sections 301 et seq., and all advertising
     and sales promotional materials of Shire or its Subsidiaries are otherwise
     in conformance with applicable regulations and (iv) neither Shire nor any
     of its Subsidiaries nor, to the knowledge of Shire, any of their respective
     officers, employees, agents or affiliates has been convicted of any crime
     or engaged in any conduct for which debarment is mandated by 21 U.S.C.
     Section 335(a) or authorized by 21 U.S.C. Section 335a(b). To the knowledge
     of Shire, Shire's contractors are in compliance with all applicable law and
     regulations and in respect of the FDA and DEA have secured all licenses,
     renewals and quotas necessary to their operation.

          Shire has made available to Roberts copies of all written
     communications to or from the FDA and the DEA relating specifically to
     Shire, its Subsidiaries and their respective operations or business.

          (x) Environmental Matters. (i) Each of Shire and its Subsidiaries
     possesses all Environmental Permits re-




<PAGE>
                                      -50-


     quired under applicable Environmental Laws to conduct its business as
     currently conducted and to own and operate its assets, and is in compliance
     in all material respects with the terms and conditions of such
     Environmental Permits.

          (ii) The execution, delivery and performance of this Agreement and the
     consummation of the transactions contemplated hereby will not affect the
     validity or require the transfer of any Environmental Permits held by Shire
     or its Subsidiaries, and will not require any notification, disclosure,
     registration, reporting, filing, investigation or redemption under any
     Environmental Law.

          (iii) Each of Shire and its Subsidiaries is in compliance in all
     material respects with all applicable Environmental Laws and has no
     material liability under any Environmental Law.

          (iv) There is no civil, criminal or administrative action, suit,
     demand, claim, hearing, notice of violation, proceeding, notice or demand
     letter, or request for information pending or, to the knowledge of Shire
     threatened, under any Environmental Law (x) against Shire or its
     Subsidiaries or (y) to the knowledge of Shire against any person or entity
     in connection with which liability could reasonably be expected to be
     imputed or attributed by law or contract to Shire or its Subsidiaries.

          (v) No property or facility presently or formerly owned, leased or
     operated by Shire or its Subsidiaries, and no property or facility at which
     Hazardous Materials of Shire or its Subsidiaries have been stored, treated
     or disposed of or at which any Hazardous Materials have been manufactured,
     handled, tested, formulated, prepared, encapsulated, packaged, bottled, or
     stored for Shire or its Subsidiaries ("Shire Product Sites") is listed or
     proposed for listing on the National Priorities List or the Comprehensive
     Environmental Response, Compensation and Liability Information System, both
     promulgated under CERCLA, or on any comparable list established under any
     Environmental Law.

          (vi) There has been no disposal, spill, discharge, emission or release
     of any Hazardous Material by Shire or its Subsidiaries on, at, under or
     from any property presently or formerly owned, leased or operated by Shire
     or its Subsidiaries and there are no Hazardous Materials located in, at, on
     or under any such facility or property,




<PAGE>
                                      -51-


     or, to the knowledge of Roberts, at any Shire Product Site or other
     location where Hazardous Materials of Shire or any of its Subsidiaries have
     been stored, treated or disposed of (a "Shire Third Party Site"), in each
     case that could reasonably be expected to result in the incurrence of any
     material liability, by Shire or its Subsidiaries under any Environmental
     Law.

          (vii) There are no underground storage tank or other underground
     storage receptacles or related piping, or any impoundments containing
     Hazardous Materials located on any facility or property owned, leased or
     operated by Shire or any of its Subsidiaries.

          (viii) No Lien has been recorded against any properties, assets or
     facilities owned, leased or operated by Shire or any of its Subsidiaries
     under any Environmental Law.

          (ix) Neither Shire nor any of its Subsidiaries is obligated to perform
     any investigation or other action under any Environmental Law pursuant to
     any order, decree, judgment or agreement by which it is bound, or has
     assumed by contract or agreement any obligation or liability under any
     Environmental Law.

          Shire has made available to Roberts all material records and files,
     including, but not limited to, all assessments, reports, studies, audits,
     analyses, tests and data, in possession, custody or control of Shire or its
     Subsidiaries concerning compliance by Shire and its Subsidiaries with, or
     liability under, any Environmental Law, including, without limitation,
     those concerning the existence of Hazardous Materials at facilities or
     properties currently or formerly owned, operated or leased by Shire or its
     Subsidiaries or at any Shire Product Site or Shire Third Party Site.

          (y) Products. Each of the products produced or sold by Shire and its
     Subsidiaries: (i) is, and at all times up to and including the date hereof
     has been, in compliance in all material respects with all applicable U.K.
     and non-U.K. laws and regulations; (ii) is, and at all relevant times has
     been, fit for the ordinary purposes for which it is intended to be used and
     conforms in all material respects to any promises or affirmations of fact
     made on the container, label or promotional materials for such product or
     in connection with its sale; and (iii) contains




<PAGE>
                                      -52-


     no design or manufacturing defect. Neither Shire nor any of its
     Subsidiaries has received notice of any product warranty claims. Neither
     Shire nor any of its Subsidiaries is aware of any facts which are
     reasonably likely to cause (i) the withdrawal or recall of any product sold
     or intended to be sold by Shire or its Subsidiaries, (ii) a change in the
     marketing classification, labeling or promotional materials of any such
     products, or (iii) a termination or suspension of marketing of any such
     products. There are no material claims pending or, to the knowledge of
     Shire, threatened against Shire or its Subsidiaries with respect to the
     quality of or absence of defects in such products nor are there any facts
     known to Shire relating to the quality of or absence of defects in such
     products which, if known by a potential claimant or governmental authority,
     could reasonably be expected to give rise to a claim or proceeding. To the
     knowledge of Shire, no supplier of a raw material required for a material
     product of Shire and the Subsidiaries for which there is not a permissible
     replacement obtainable under commercially reasonable terms, has indicated
     that it will not continue to supply such raw materials on terms consistent
     with those on the date hereof.

          (z) Marketing Practices. Shire's operations and commercial conduct and
     those of its Subsidiaries have at all times conformed in all material
     respects to the Code of Marketing Practices of the Pharmaceutical Research
     Industry Association.

          (aa) Ordinary Shares. As of the Effective Time, the Ordinary Shares
     comprising the Merger Consideration (including Ordinary Shares delivered to
     the Depositary underlying the Shire ADSs constituting Merger Consideration)
     will have been duly authorized for issuance and, when issued and delivered
     in accordance with the terms of this Agreement, will be validly issued and
     fully paid.

          (bb) Pooling. Neither Shire nor any of its Affiliates has taken or
     agreed to take any action or failed to take any action that would prevent
     the Merger from being treated for financial accounting purposes as a
     "pooling of interests" in accordance with US GAAP and the regulations and
     interpretations of the SEC.

          (cc) Merger Consideration. As of the Effective Time, the Shire ADSs
     and Ordinary Shares received by the Holders as Merger Consideration will
     represent less than




<PAGE>
                                      -53-


     fifty percent of both the total voting power and the total value of the
     outstanding stock of Shire within the contemplation of Treas. Reg. ss.
     1.367(a)-3(c)(1)(i).

          (dd) Active Trade or Business. Shire, a "qualified subsidiary" (as
     defined in Treas. Reg. ss. 1.367(a)-3(c)(5)(vii)) of Shire or a "qualified
     partnership" (as defined in Treas. Reg. ss. 1.367(a)-3(c)(5)(viii)) of
     which Shire is a partner will, as of the Effective Time, have been engaged
     in an active trade or business outside the United States for the entire
     36-month period immediately before the Effective Time, within the meaning
     of and as contemplated by Treas. Reg. ss. 1.367(a)-3(c)(3). None of Shire,
     any qualified subsidiary of Shire or any qualified partnership of which
     Shire is a partner has, nor will have as of the Effective Time, any
     intention to dispose of or discontinue any trade or business referred to in
     the previous sentence if doing so would cause the active trade or business
     test of Treas. Reg. ss. 1.367(a)-3(c)(3) not to be satisfied.

          (ee) Asset Acquisitions. As of the Effective Time, none of Shire, any
     qualified subsidiary of Shire or any qualified partnership of which Shire
     is a partner (each as defined above in Section 3.2(dd)) will own any assets
     acquired outside the ordinary course of business within the preceding
     36-month period that would cause Shire to fail to satisfy the
     "substantiality test" set forth in Treas. Reg. ss. 1.367(a)-3(c)(3)(iii).

          (ff) Ownership of Roberts Shares. Except as contemplated in this
     Agreement and the Option Agreement as of the date hereof and the Effective
     Time, none of Shire, any of its Subsidiaries or, to Shire's knowledge, any
     of its "affiliates" or "associates" (as such terms are defined in the
     Shareholder Protection Act), (i) owns, or during the five-year period prior
     to the date hereof owned, or has any rights to acquire or vote any shares
     of Common Stock or (ii) has any agreement, arrangement or understanding for
     the purpose of acquiring, holding, voting or disposing of Common Stock with
     any other person that beneficially owns, or whose affiliates or associates
     beneficially own, Common Stock.



<PAGE>
                                      -54-


                                   ARTICLE IV

                              COVENANTS OF ROBERTS

     4.1. Regular Course of Business. Except in connection with the performance
by Roberts of its obligations under the Agreement, until the Effective Time,
Roberts shall conduct its and its Subsidiaries' business only in the ordinary
course and shall use reasonable efforts to maintain and preserve its business
organization, assets, employees and business relationships and to maintain all
of its material properties and assets in useful and good condition, ordinary
wear and tear excepted.

     4.2. Certain Prohibited Activities. Until the Effective Time, except as
contemplated by this Agreement or as set forth on Section 4.2 of the Roberts
Disclosure Schedule, Roberts shall not, and shall not permit any of its
Subsidiaries to, without the prior written consent of Shire: (a) cease to be a
corporation duly organized, validly existing and in good standing under the laws
of its jurisdiction of incorporation, or in good standing as a foreign
corporation in any jurisdiction where the character of its assets or nature of
its business makes such qualification necessary; (b) authorize or issue any
additional shares of its capital stock, any Equity Equivalents, any debt
securities or other evidence of its indebtedness or any SARs; (c) repay any of
its Indebtedness prior to scheduled maturity (other than in the ordinary course
of business) or redeem or otherwise acquire any of its capital stock or any
Equity Equivalents or make any payment with respect to any of the foregoing
(other than regular, periodic payments of interest made with respect to any
Indebtedness); (d) split, combine or reclassify any of its capital stock or
declare, set aside or pay any dividend or other distribution in respect of any
of its capital stock; (e) acquire any stock, partnership or other equity
interest in or any equity or debt security of any other person or entity; (f)
amend its Certificate of Incorporation or By-Laws (or equivalent charter
documents); (g) violate or fail to comply in any material respect with any
statute, law, ordinance, regulation, rule, order or other legal requirement of
any government, authority or any other governmental department or agency, or any
judgment, decree or order of any court or governmental body or agency applicable
to its business or operations (other than any violations or failures to comply
which could not reasonably be expected, individually or in the aggregate, to
have a Roberts Material Adverse Effect); (h) enter into any contract, agreement
or other commitment with any




<PAGE>
                                      -55-


present or former director, officer or securityholder of Roberts or any person
or entity controlled by any such person other than in the ordinary course of
business and where the amount involved is not in excess of $500,000; (i) acquire
or dispose of any material real property or any material leasehold interest in
real property, or create or suffer to exist any Lien on any material assets
owned or leased by it; (j) fail to comply in all material respects with all of
its obligations with respect to all material Permits or voluntarily take or omit
to take any action which could reasonably be expected to result in the
revocation, nonrenewal, modification, suspension or termination of any such
Permit (other than any violations or failures to comply which could not
reasonably be expected, individually or in the aggregate, to have a Roberts
Material Adverse Effect); (k) (i) grant to any officer of Roberts or any of its
Subsidiaries any increase in compensation, (ii) grant to any employee of Roberts
or any of its Subsidiaries any increase in severance or termination pay, (iii)
enter into any employment, severance or termination agreement with any employee
of Roberts or any of its Subsidiaries or (iv) enter into any Employment
Obligation, or permit the modification or termination of any existing Employment
Obligation; (l) dispose of, permit to lapse, modify, terminate, grant any
interest to any person or entity in, or create or suffer to exist any Lien on or
with respect to, any Roberts Intellectual Property; (m) take any action that
would cause it to fail to maintain in full force and effect, comply in all
material respects with all of the terms and provisions of or pay all premiums
due on any Insurance Policy; (n) enter into any material agreement or permit the
modification or termination of any material agreement outside the ordinary
course of business; (o) merge or consolidate with any other person or entity or
acquire control of or purchase all or substantially all of the assets of any
other person or entity; (p) voluntarily incur or permit the incurrence of any
liability not in the ordinary course of business and in excess of $1,000,000;
(q) adopt a plan of complete or partial liquidation; or (r) undertake any action
which would jeopardize accounting for the Merger as a pooling of interests.

     4.3. Notice of Certain Events. Roberts will give notice to Shire, promptly
after obtaining knowledge thereof, of (i) any representation or warranty made by
it contained in this Agreement that is qualified as to materiality becoming
untrue or inaccurate in any respect or any such representation or warranty that
is not so qualified becoming untrue or inaccurate in any material respect or
(ii) the failure by it to comply with or satisfy in any material respect any
covenant, condition or



<PAGE>
                                      -56-


agreement to be complied with or satisfied by it under this Agreement.

     4.4. Access. Roberts shall afford the officers, employees and
representatives of Shire, and its counsel and auditors, reasonable access during
normal business hours prior to the Effective Time to its facilities, properties,
equipment, files, accounts, books and records so that Shire may have full
opportunity to make such investigations as it may desire to make of the affairs
of Roberts. Shire will hold, and will cause its respective officers, employees,
accountants, counsel, financial advisers and other representatives and
affiliates to hold, any confidential information in accordance with the terms of
that certain Confidentiality Agreement dated as of June 1, 1999, between Shire
and Roberts.

     4.5. Approvals. Roberts shall use all reasonable efforts to take or cause
to be taken all action, and to do or cause to be done all things reasonably
necessary, proper or advisable in order to fulfill and perform its obligations
under this Agreement or otherwise consummate and make effective the transactions
contemplated hereby. Roberts shall use all commercially reasonable efforts to
obtain or cause to be obtained all Roberts Governmental Approvals and Roberts
Third Party Approvals.

     4.6. No Solicitation. (a) Prior to the Effective Time, Roberts agrees that
neither it, any of its Subsidiaries, nor any of their respective directors,
officers, employees, agents or representatives of the foregoing, will, directly
or indirectly, (i) solicit or initiate (including by way of furnishing or
disclosing non-public information) any inquiries or the making of any proposal
with respect to any merger, consolidation or other business combination
involving Roberts or the acquisition of all or any significant part of the
assets or capital stock of Roberts (a "Roberts Acquisition Transaction") or (ii)
negotiate, explore or otherwise engage in discussions with any person (other
than Shire and its representatives) with respect to any Roberts Acquisition
Transaction, or which may reasonably be expected to lead to a proposal for a
Roberts Acquisition Transaction or enter into any agreement, arrangement or
understanding with respect to any such Roberts Acquisition Transaction or which
would require it to abandon, terminate or fail to consummate the Merger or any
other transaction contemplated by this Agreement; provided, however, that
Roberts may, in response to an unsolicited written proposal from a third party
regarding a Roberts Superior Proposal (as hereinafter defined), furnish
information to, negotiate or otherwise engage


<PAGE>
                                      -57-


in discussions with such third party, if the Board of Directors of Roberts
determines in good faith, after consultation with its financial advisors and
based upon advice of outside counsel that such action is required for the Board
of Directors to comply with its fiduciary duties under applicable law.

     (b) Except as may be required pursuant to the fiduciary duties of Roberts'
Board of Directors under applicable law, Roberts agrees that, as of the date
hereof, it and its Subsidiaries, and the respective directors, officers,
employees, agents and representatives of the foregoing, shall immediately cease
and cause to be terminated any existing activities, discussions or negotiations
with any person (other than Shire and its representatives) conducted heretofore
with respect to any Roberts Acquisition Transaction. Roberts agrees to promptly
advise Shire of any inquiries or proposals received by, any such information
requested from, or any negotiations or discussions sought to be initiated or
continued with, Roberts or its Subsidiaries, or any of the respective directors,
officers, employees, agents or representatives of the foregoing, in each case
from a person (other than Shire and its representatives) with respect to a
Roberts Acquisition Transaction, and the terms hereof, including the identity of
such third party and the general terms of any financing arrangement or
commitment in connection with such Roberts Acquisition Transaction, and, except
as may otherwise be required pursuant to the fiduciary duties of Roberts' Board
of Directors under applicable law, to update on an ongoing basis or upon Shire's
reasonable request, the status thereof, as well as any actions taken or other
developments pursuant to this Section 4.6. As used herein, "Roberts Superior
Proposal" means a bona fide, written and unsolicited proposal or offer made by
any persons (or group) (other than Shire or any of its Subsidiaries) with
respect to a Roberts Acquisition Transaction (i) on terms which the Board of
Directors of Roberts determines in good faith, and in the exercise of reasonable
judgment (based on the advice of independent financial advisors and legal
counsel), to be more favorable to Roberts and its shareholders than the
transactions contemplated hereby (including taking into account the financing
thereof.)

     4.7. Pooling of Interests. Roberts shall use all reasonable efforts to
cause the Merger to be accounted for as a "pooling of interests" in accordance
with US GAAP, Accounting Principles Board Opinion 16 and applicable SEC rules,
regulations and policies and shall take no action that would cause such
accounting treatment not to be obtained.



<PAGE>
                                      -58-


     4.8. ISRA. Roberts shall obtain from the New Jersey Department of
Environmental Protection either (i) a declaration of non-applicability of the
New Jersey Industrial Site Recovery Act ("ISRA") to the Merger or any other
transactions contemplated thereby, or (ii) approval of a negative declaration or
other action required to comply with ISRA, in each case which is reasonably
acceptable to Shire.

                                    ARTICLE V

                     COVENANTS OF SHIRE AND ACQUISITION SUB

     5.1. Regular Course of Business. Except in connection with the performance
by Shire and Acquisition Sub of their respective obligations under this
Agreement, until the Effective Time, Shire shall conduct its and its
Subsidiaries' business only in the ordinary course and shall use reasonable
efforts to maintain and preserve its business organization, assets, employees
and business relationships and to maintain all of its material properties and
assets in useful and good condition, ordinary wear and tear excepted.

     5.2. Certain Prohibited Activities. Until the Effective Time, except as
contemplated by this Agreement or as set forth on Section 5.2 of the Shire
Disclosure Schedule, Shire shall not, and shall not permit any of its
Subsidiaries to, without the prior written consent of Roberts: (a) cease to be a
corporation duly organized, validly existing and, where applicable, in good
standing under its jurisdiction of incorporation, or in good standing as a
foreign corporation in any applicable jurisdiction where the character of its
assets or nature of its business makes such qualification necessary; (b)
authorize or issue any additional shares of its capital stock, any Equity
Equivalents, any debt securities or other evidence of its indebtedness or any
SARs; (c) repay any of its Indebtedness prior to scheduled maturity (other than
in the ordinary course of business) or redeem or otherwise acquire any of its
capital stock or any Equity Equivalents or make any payment with respect to any
of the foregoing (other than regular, periodic payments of interest made with
respect to any Indebtedness); (d) split, combine or reclassify any of its
capital stock or declare, set aside or pay any dividend or other distribution in
respect of any of its capital stock; (e) acquire any stock, partnership or other
equity interest in or any equity or debt security of any other person or entity;
(f) amend its Memorandum and Articles of Association (or equivalent char-



<PAGE>
                                      -59-


ter documents); (g) violate or fail to comply in any material respect with any
statute, law, ordinance, regulation, rule, order or other legal requirement of
any government, authority or any other governmental department or agency, or any
judgment, decree or order of any court or governmental body or agency applicable
to its business or operations (other than any violations or failures to comply
which could not reasonably be expected, individually or in the aggregate, to
have a Shire Material Adverse Effect); (h) enter into any contract, agreement or
other commitment with any present or former director, officer or securityholder
of Shire or any person or entity controlled by any such person other than in the
ordinary course of business and where the amount involved is not in excess of
$500,000; (i) fail to comply in all material respects with all of its
obligations with respect to all material Permits or voluntarily take or omit to
take any action which could reasonably be expected to result in the revocation,
nonrenewal, modification, suspension or termination of any such Permit (other
than any violations or failures to comply which could not reasonably be
expected, individually or in the aggregate, to have a Shire Material Adverse
Effect); (j) (i) grant to any officer of Shire or any of its Subsidiaries any
increase in compensation, (ii) grant to any employee of Shire or any of its
Subsidiaries any increase in severance or termination pay, (iii) enter into any
employment, severance or termination agreement with any employee of Shire or any
of its Subsidiaries or (iv) enter into any Employment Obligation or permit the
modification or termination of any existing Employment Obligation; (k) dispose
of, permit to lapse, modify, terminate, grant any interest to any person or
entity in, or create or suffer to exist any Lien with respect to, any Shire
Intellectual Property; (l) take any action that would cause it to fail to
maintain in full force and effect, comply in all material respects with all of
the terms and provisions of or pay all premiums due on any Insurance Policy; (m)
enter into any material agreement or permit the modification of any material
agreement outside the ordinary course of business; (n) merge or consolidate with
any other person or entity or acquire control of or purchase all or
substantially all of the assets of any other person or entity; (o) voluntarily
incur or permit the incurrence of any liability not in the ordinary course of
business and in excess of $1,000,000; (p) adopt a plan of complete or partial
liquidation; or (q) undertake any actions which would jeopardize accounting for
the Merger as a pooling of interests.

     5.3. Notice of Certain Events. Each of Shire and Acquisition Sub will give
notice to Roberts promptly after obtaining knowledge thereof, of (i) any
representation or war-



<PAGE>
                                      -60-


ranty made by it contained in this Agreement that is qualified as to materiality
becoming untrue or inaccurate in any respect or any such representation or
warranty that is not so qualified becoming untrue or inaccurate in any material
respect or (ii) the failure by it to comply with or satisfy in any material
respect any covenant, condition or agreement to be complied with or satisfied by
it under this Agreement.

     5.4. Access. Shire and Acquisition Sub shall afford the officers, employees
and representatives of Roberts, and its counsel and auditors, reasonable access
during normal business hours during the period prior to the Effective Time to
their respective facilities, properties, equipment, files, accounts, books and
records so that Roberts may have full opportunity to make such investigations as
it may desire to make of the affairs of Shire and Acquisition Sub. Roberts will
hold, and will cause its respective officers, employees, accountants, counsel,
financial advisers, and other representatives and affiliates to hold, any
confidential information in accordance with the terms of that certain
Confidentiality Agreement dated as of June 1, 1999, between Shire and Roberts.

     5.5. Approvals. Each of Shire and Acquisition Sub shall use all reasonable
efforts to take or cause to be taken all actions, and to do or cause to be done
all things, reasonably necessary, proper or advisable in order to fulfill and
perform its obligations under this Agreement or otherwise consummate or make
effective the transactions contemplated hereby. Each of Shire and Acquisition
Sub shall use all commercially reasonable efforts to obtain all Shire
Governmental Approvals and Shire Third Party Approvals.

     5.6. No Solicitation. (a) Prior to the Effective Time, Shire agrees that
neither it, any of its Subsidiaries, nor any of their respective directors,
officers, employees, agents or representatives of the foregoing, will, directly
or indirectly, (i) solicit or initiate (including by way of furnishing or
disclosing non-public information) any inquiries or the making of any proposal
with respect to any merger, consolidation or other business combination
involving Shire or the acquisition of all or any significant part of the assets
or capital stock of Shire (a "Shire Acquisition Transaction") or (ii) negotiate,
explore or otherwise engage in discussions with any person (other than Roberts
and its representatives) with respect to any Shire Acquisition Transaction, or
which may reasonably be expected to lead to a proposal for a Shire Acquisition
Transaction or enter into any agreement, arrangement or understanding with
respect to any such Shire Acquisition Trans-




<PAGE>
                                      -61-


action or which would require it to abandon, terminate or fail to consummate the
Merger or any other transaction contemplated by this Agreement; provided,
however, that Shire may, in response to an unsolicited written proposal from a
third party regarding a Shire Superior Proposal (as hereinafter defined),
furnish information to, negotiate or otherwise engage in discussions with such
third party, if the Board of Directors of Shire determines in good faith, after
consultation with its financial advisors and based upon advice of outside
counsel that such action is required for the Board of Directors to comply with
its fiduciary duties under applicable law.

     (b) Except as may be required pursuant to the fiduciary duties of Shire's
Board of Directors under applicable law, Shire agrees that, as of the date
hereof, it and its Subsidiaries, and the respective directors, officers,
employees, agents and representatives of the foregoing, shall immediately cease
and cause to be terminated any existing activities, discussions or negotiations
with any person (other than Roberts and its representatives) conducted
heretofore with respect to any Shire Acquisition Transaction. Shire agrees to
promptly advise Roberts of any inquiries or proposals received by, any such
information requested from, or any negotiations or discussions sought to be
initiated or continued with, Shire or its Subsidiaries, or any of the respective
directors, officers, employees, agents or representatives of the foregoing, in
each case from a person (other than Shire and its representatives) with respect
to a Shire Acquisition Transaction, and the terms hereof, including the identity
of such third party and the general terms of any financing arrangement or
commitment in connection with such Shire Acquisition Transaction, and, except as
may otherwise be required pursuant to the fiduciary duties of Shire's Board of
Directors under applicable law, to update on an ongoing basis or upon Roberts'
reasonable request, the status thereof, as well as any actions taken or other
developments pursuant to this Section 5.6. As used herein, "Shire Superior
Proposal" means a bona fide, written and unsolicited proposal or offer made by
any persons (or group) (other than Roberts or any of its Subsidiaries) with
respect to a Shire Acquisition Transaction (i) on terms which the Board of
Directors of Shire determines in good faith, and in the exercise of reasonable
judgment (based on the advice of independent financial advisors and legal
counsel), to be more favorable to Shire and its shareholders than the
transactions contemplated hereby (including taking into account the financing
thereof.)

     5.7. Pooling of Interests. Shire shall use all reasonable efforts to cause
the Merger to be accounted for as a



<PAGE>
                                      -62-


"pooling of interests" in accordance with US GAAP, Accounting Principles Board
Opinion 16 and applicable SEC rules, regulations and policies and shall take no
action that would cause such accounting treatment not to be obtained.

     5.8. Indemnification. (a) From and after the Effective Time and until the
sixth anniversary of the Effective Time and for so long thereafter as any claim
for indemnification asserted on or prior to such date has not been fully
adjudicated, Shire and the Surviving Corporation shall indemnify, defend and
hold harmless each individual who is now, or has been at any time prior to the
date hereof or who becomes prior to the Effective Time, a director or officer of
Roberts or any of its Subsidiaries against all losses, claims, damages, costs,
expenses (including attorneys' fees) or liabilities (including attorneys' fees)
arising out of actions or omissions or alleged actions or omissions occurred at
or prior to the Effective Time to the same extent and on the same terms and
conditions (including with respect to advancement of expenses) permitted or
required under applicable law and Roberts' Certificate of Incorporation and
By-Laws in effect at the date hereof.

     (b) For a period of six years after the Effective Time, Shire and the
Surviving Corporation shall cause to be maintained in effect the current
policies of directors' and officers' liability insurance maintained by Roberts
(provided that the Surviving Corporation may substitute therefor policies of at
least the same coverage and amounts containing terms and conditions which are no
less advantageous to the insured parties) with respect to claims arising from
facts or events which occurred on or before the Effective Time; provided,
however, that if the premiums with respect to such insurance exceed 150% of the
annual premiums paid as of the date hereof by Roberts for such insurance, Shire
and the Surviving Corporation shall be obligated to purchase directors' and
officers' liability insurance with the maximum coverage as can be obtained at an
annual premium equal to 150% of the annual premiums paid by Roberts as of the
date hereof.

     (c) The provisions of this Section are intended to be for the benefit of,
and shall be enforceable by, each indemnified party and each party entitled to
insurance coverage under paragraph (b) above, respectively, and his or her heirs
and legal representatives, and shall be in addition to any other rights an
indemnified party may have under the certificates or articles of incorporation
or by-laws of the Surviving Corporation or any of its Subsidiaries, under the
New Jersey Law or otherwise.



<PAGE>
                                      -63-


                                   ARTICLE VI

                          AGREEMENTS REGARDING OPTIONS
                               and other benefits

     6.1. Stock Option Plans. (a) At the Effective Time, Roberts shall, if
necessary, have amended (and Shire and the Surviving Corporation shall have
approved and adopted, respectively) each of the Roberts Option Plans to provide
that each of the Options shall be assumed by Shire (or the Surviving
Corporation) and made applicable to the purchase of Ordinary Shares as provided
in this Section 6.1. Shire shall assume or replace such Options (or fraction
thereof) so that each holder of an Option (an "Optionee") shall have such
Optionee's Option apply to that number of Ordinary Shares (adjusted to the
nearest whole share) equal to the product of (i) the number of all Options of
such Optionee immediately prior to the Effective Time and (ii) the Exchange
Ratio. The exercise price per share for each Optionee's Options (adjusted to the
nearest pence) assumed or replaced will equal the old exercise price per share
of Common Stock divided by the Exchange Ratio; provided, however, that in the
case of any Option to which Section 421 of the Code continues to apply by reason
of its qualification under Section 422 of the Code ("incentive stock options"),
the option price, the number of shares purchasable pursuant to such option and
the terms and conditions of exercise of such option shall be determined in order
to comply with Section 424(a) of the Code and the regulations promulgated
thereunder. Without limiting the foregoing, the duration and other terms of each
assumed or replaced Option immediately after the Effective Time (unless
otherwise agreed in writing by the Optionee with respect to a particular Option)
shall be the same as the corresponding Options that were in effect immediately
before the Effective Time, except that all references to Roberts in the Roberts
Option Plans (and the corresponding references in each option agreement
documenting each such Option) shall be deemed to be references to Shire or the
Surviving Corporation, as applicable; provided, however, that the exercise price
with respect to each Ordinary Share shall not be less than the nominal value of
(pound)0.05 thereof. Roberts will terminate its Employee Stock Purchase Plan
prior to the closing and extinguish all rights thereunder.

     (b) As soon as practicable after the Effective Time, Shire shall deliver to
each Optionee appropriate notices setting forth such Optionee's rights pursuant
to the Shire Option




<PAGE>
                                      -64-


Plans and the agreements evidencing the grants of such Options shall continue in
effect on the same terms and conditions.

     (c) Shire shall take all corporate action necessary to reserve for issuance
a sufficient number of Ordinary shares for delivery upon exercise of Options. As
soon as practicable after the Effective Time, Shire shall file a registration
statement on Form F-3, Form S-8, or another appropriate form, as the case may be
(or any successor form), with respect to the Ordinary Shares subject to such
options and shall use its reasonable best efforts to maintain the effectiveness
of such registration statement or registration statements (and maintain the
current status of the prospectus or prospectuses contained therein) for so long
as such options remain outstanding.

     6.2. Continuation of Benefits. During the period from the Effective Time
until December 31, 2001, Shire shall maintain or cause to be maintained wages,
compensation levels, employee pension and welfare plans for the benefit of
employees and former employees of Roberts and its Subsidiaries, which are, in
the aggregate, equal or greater in value than those wages, compensation levels
and other benefits provided under Roberts' Employment Obligations that are in
effect on the date hereof. Nothing in this Agreement shall be construed as
limiting in any way the right of Shire after the Effective Time to terminate the
employment of or lay-off any employee of Roberts.

     6.3. Severance Policy and Other Agreements. Shire shall honor or cause to
be honored all severance agreements and employment agreements with Roberts'
directors, officers and employees.

     6.4. 1999 Bonus. Shire will pay, or cause to be paid, bonuses for calendar
year 1999 to Roberts' employees participating in Roberts' RPC Incentive
Compensation Program in amounts equal to each such Roberts employee's bonus for
the year, on a basis consistent with past practice, within the target range
established for each employee (but, in the aggregate, not in excess of
U.S.$1,500,000) as determined by the chief executive of Roberts immediately
prior to the Closing Date (all in accordance with the RPC Incentive Compensation
Program set forth in Schedule 6.4 of the Roberts Disclosure Schedule). Annual
bonus for 1999 for the four senior officers of Roberts who do not participate in
the RPC Incentive Compensation Program shall be as determined by the
Compensation Committee of Roberts' Board of Directors immediately prior to the
Closing Date in a manner which is consistent with past practice based upon



<PAGE>
                                      -65-


performance, and shall be in an aggregate amount not greater than
U.S.$1,000,000.

     6.5. Waiver of Preexisting Conditions; Credit for Deductibles; Service
Credit. Shire will, or will cause the Surviving Corporation to, (i) waive all
limitations as to preexisting conditions with respect to participation and
coverage requirements applicable to the employees and former employees of
Roberts and its Subsidiaries under any welfare plan that such employees or
former employees may be eligible to participate in after the Effective Time,
(ii) provide each employee of Roberts and its Subsidiaries with credit for any
co-payments and deductibles paid during the applicable plan year prior to the
Effective Time in satisfying any applicable deductible or out-of-pocket
requirements under any welfare plans that such employees are eligible to
participate in after the Effective Time, and (iii) provide each employee of
Roberts and its Subsidiaries with credit for all service with Roberts and its
affiliates for purposes of vesting and eligibility to participate under each
employee benefit plan, program, or arrangement of the Purchaser or its
affiliates in which such employees are eligible to participate.

                                   ARTICLE VII

                              CONDITIONS PRECEDENT

     7.1. Conditions to the Obligations of Each Party to Effect the Merger. The
respective obligations of each of the parties to effect the Merger shall be
subject to the satisfaction or waiver of each of the following conditions at or
prior to the Closing:

          (a) Shareholder Approvals. The Roberts Shareholder Approval and Shire
     Shareholder Approval shall have been obtained.

          (b) Certain Approvals. All Roberts Governmental Approvals and Shire
     Governmental Approvals shall have been obtained, satisfied, waived or
     expired, as applicable.

          (c) No Proceeding or Litigation. No order, injunction, decree or
     judgment of any court or governmental body or agency shall be in effect
     which materially restrains or prohibits the transactions contemplated
     hereby, and no suit, action, investigation, inquiry or proceeding by any



<PAGE>
                                      -66-


     governmental body or agency or legal or administrative proceeding by any
     governmental body or agency shall have been instituted, or threatened in
     writing, which questions the validity or legality of the transactions
     contemplated hereby.

          (d) Securities Laws. The Form F-4 filed by Shire and the Form F-6
     filed by the Depositary shall have become effective under the Securities
     Act and Exchange Act, as applicable, and shall not be the subject of any
     stop order or proceedings seeking a stop order, and Shire shall have
     received all state securities or "blue sky" authorizations necessary to
     issue Shire ADRs and Ordinary Shares pursuant to this Agreement.

     7.2. Additional Conditions to the Obligations of Roberts. The obligation of
Roberts to effect the Merger is also subject to the satisfaction or waiver of
each of the following conditions at or prior to Closing:

          (a) Agreements. Each of Shire and Acquisition Sub shall have performed
     or complied in all material respects with each covenant, agreement and
     obligation to be performed or complied with by it hereunder on or prior to
     the Closing Date.

          (b) Representations and Warranties. The representations and warranties
     of Shire and Acquisition Sub set forth in this Agreement shall be true and
     correct in all material respects (except that where any statement in a
     representation or warranty expressly includes a standard of materiality,
     such statement shall be true and correct in all respects giving effect to
     such standard) at and as of the Closing Date as if made at and as of such
     time or, if made as of a specified date, as of such date.

          (c) Officer's Certificate. Roberts shall have received a certificate,
     dated the Closing Date, of the President or a Vice President of Acquisition
     Sub and of a director of Shire to the effect that the conditions specified
     in paragraphs (a) and (b) above have been fulfilled.

          (d) Consents from Third Parties. All Shire Third Party Approvals shall
     have been obtained.

          (e) Listing. The London Stock Exchange shall have granted admission of
     the Ordinary Shares comprising the Merger Consideration to the Official
     List, subject only to



<PAGE>
                                      -67-


     allotment; and the allotment of the Ordinary Shares comprising the Merger
     Consideration shall have occurred, subject only to admission becoming
     effective in accordance with paragraph 7.1 of the Listing Rules of LSE.

          (f) Tax Opinions. Roberts shall have received an opinion, relying on
     appropriate representations, of either Milbank, Tweed, Hadley & McCloy LLP,
     counsel to Roberts, or Cahill Gordon & Reindel, counsel to Shire to the
     effect that the Merger will constitute a reorganization described in Code
     Section 368(a)(1)(A) and Code Section 368(a)(2)(E) and no gain or loss will
     be recognized by Roberts or any Holder except that (i) a Holder who
     receives cash in lieu of fractional Ordinary Shares or Shire ADSs will
     recognize capital gain or capital loss equal to the difference between the
     cash received and the basis of the Holder's shares of Common Stock
     allocated to the fractional interest and (ii) any Holder required to enter
     into a "gain recognition agreement" within the meaning of Treas. Reg. ss.
     1.367(a)-3(c)(1)(iii)(B) must do so in order to avoid immediate gain
     recognition and may be required to recognize gain at the time and in the
     amount specified in the gain recognition agreement, which opinion shall be
     dated on or about the date that is two business days prior to the date the
     Proxy Statement is first mailed to stockholders of Roberts, shall not have
     been withdrawn or modified in any material respect.

          (g) Pooling Letter. There shall have been delivered to Roberts a
     letter from its independent auditors, dated as of the Closing Date and
     addressed to Roberts, reasonably satisfactory in form and substance to
     Roberts, setting forth the concurrence of Roberts' independent auditors
     with the conclusion of Roberts' management that it will be appropriate to
     account for the Merger as a "pooling of interests" under US GAAP,
     Accounting Principles Board Opinion No. 16 and all rules, regulations and
     policies of the SEC, if the Merger is consummated in accordance with this
     Agreement.

          (h) Nasdaq. The Shire ADSs to be issued in the Merger and under the
     Roberts Option Plans after the Merger in accordance with this Agreement
     shall have been approved for listing on the Nasdaq National Market.

     7.3. Additional Conditions to the Obligations of Shire and Acquisition Sub.
The obligations of Shire and Acquisition Sub to effect the Merger are also
subject to the satis-



<PAGE>
                                      -68-


faction or waiver of each of the following conditions at or prior to the
Closing:

          (a) Agreements. Roberts shall have performed each covenant, agreement
     and obligation to be performed or complied with by it hereunder on or prior
     to the Closing Date.

          (b) Representations and Warranties. The representations and warranties
     of Roberts set forth in this Agreement shall be true and correct in all
     material respects (except that where any statement in a representation or
     warranty expressly includes a standard of materiality, such statement shall
     be true and correct in all respects giving effect to such standard) at and
     as of the Closing Date as if made at and as of such time or, if made as of
     a specified date, as of such date.

          (c) Roberts Officer's Certificate. Shire shall have received a
     certificate, dated the date of the Closing, of the President or Vice
     President of Roberts to the effect that the conditions specified in
     paragraphs (a) and (b) above have been fulfilled.

          (d) Pooling Letter. There shall have been delivered to Shire a letter
     from its independent auditors, dated as of the Closing Date and addressed
     to Shire, reasonably satisfactory in form and substance to Shire, setting
     forth the concurrence of Shire's independent auditors with the conclusion
     of Shire's management that it will be appropriate to account for the Merger
     as a "pooling of interests" under US GAAP, Accounting Principles Board
     Opinion No. 16 and all rules, regulations and policies of the SEC, if the
     Merger is consummated in accordance with this Agreement.

                                  ARTICLE VIII

                                Other Agreements

     8.1. Preparation of Form F-4, Form F-6, the Proxy Statement and the UK
Disclosure Document. As soon as practicable following the date of this
Agreement, Roberts shall, in cooperation with Shire, prepare and file with the
SEC the Proxy Statement and Shire shall, in cooperation with Roberts, prepare
and file with the SEC the Form F-4, in which the Proxy Statement will be
included as a prospectus. Each of Roberts and




<PAGE>
                                      -69-


Shire shall use its best efforts to have the Form F-4 declared effective under
the Securities Act as promptly as practicable after such filing. Shire shall
also, as promptly as practicable, use its best efforts to cause the Depositary
to file with the SEC a registration statement on Form F-6 (the "Form F-6") with
respect to Shire ADRs under the Securities Act and use its best efforts to have
the Form F-6 declared effective as soon as practicable. Shire shall also take
any action (other than qualifying to do business in any jurisdiction in which it
is not now so qualified) required to be taken under any applicable United States
state securities laws in connection with the issuance of Shire ADRs and Ordinary
Shares in the Merger and Shire Ordinary Shares under the Roberts Stock Plans and
Roberts shall furnish all information concerning Roberts and the holders of
Common Stock as may be reasonably requested in connection with any such action.

     8.2. Roberts Shareholders Meeting. Roberts shall, as soon as practicable
following the date of this Agreement, duly call, give notice of, convene and
hold a meeting of its shareholders (the "Roberts Shareholders Meeting") for the
purpose of obtaining the Roberts Shareholder Approval. Except as required to
comply with the fiduciary duties of the Board of Directors as advised by outside
counsel, Roberts will, through its Board of Directors, recommend to its
shareholders approval of all matters required to be so approved. Roberts shall
use its best efforts to cause the Proxy Statement to be mailed to Roberts'
shareholders as promptly as practicable after the Form F-4 is declared effective
under the Securities Act and, if necessary, after the Proxy Statement shall have
been so mailed, promptly circulate amended, supplemental or supplemented proxy
materials and, if required in connection therewith, resolicit proxies, it being
understood that Roberts shall not be required to hold more than one meeting of
shareholders.

     8.3. Shire Shareholders Meeting. Shire will, as soon as practicable
following the date of this Agreement, duly call, give notice of, convene and
hold an extraordinary general meeting of its ordinary shareholders (the "Shire
Shareholders Meeting") for the purpose of obtaining the Shire Shareholder
Approval. Except as required to comply with the fiduciary duties of the Board of
Directors as advised by outside counsel, Shire will, through its Board of
Directors, recommend to its shareholders approval of all such matters required
to be so approved. In connection with the Shire Shareholders Meeting (i) Shire
will, as soon as practicable after the date of this Agreement, prepare and file
with the LSE, and will use its best efforts to have cleared by the LSE and will
thereafter mail to




<PAGE>
                                      -70-


its shareholders the UK Disclosure Documents, which will comply with all legal
requirements applicable to the Shire Shareholders Meeting and (ii) if necessary,
after the UK Disclosure Documents have been so posted, promptly circulate
amended, supplemental or supplemented materials and, if required in connection
therewith, resolicit votes, it being understood that Shire shall not be
obligated to hold more than one meeting of shareholders.

     8.4. Acquisition Sub Actions. Shire will take all action within its control
which is necessary or appropriate to cause Acquisition Sub to perform its
obligations under this Agreement and to consummate the transactions contemplated
hereby.

                                   ARTICLE IX

                        TERMINATION, AMENDMENT AND WAIVER

     9.1. Termination. This Agreement may be terminated at any time prior to the
Effective Time, whether before or after the Roberts Shareholder Approval or the
Shire Shareholder Approval:

          (a) by mutual written consent of Shire and Roberts;

          (b) by either Shire or Roberts upon notice thereof given in writing to
     the other party if (i) any governmental entity shall have issued an order,
     decree or ruling or taken any other action permanently enjoining,
     restraining or otherwise prohibiting the consummation of the Merger and
     such order, decree or ruling or other action shall have become final and
     nonappealable (a "Final Order") or (ii) the Effective Time has not occurred
     on or before December 31, 1999 unless a later date is established by mutual
     written consent of Shire and Roberts or unless the failure to consummate
     the Merger is the result of a breach of a covenant set forth in this
     Agreement or a misrepresentation or breach of any warranty set forth in
     this Agreement by the party seeking to terminate this Agreement;

          (c) by the Board of Directors of Shire or Roberts, if (x) the Shire
     Shareholder Approval shall fail




<PAGE>
                                      -71-


     to be obtained upon a vote therefor taken at the Shire Shareholders Meeting
     or (y) Roberts Shareholder Approval shall fail to be obtained upon a vote
     therefor taken at the Roberts Shareholders Meeting, unless due to delay or
     default on the part of Roberts, in the case of the Roberts Shareholder
     Approval, or due to delay or default on the part of Shire or Acquisition
     Sub, in the case of the Shire Shareholder Approval;

          (d) by action of the Board of Directors of Shire and notice thereof
     given in writing to Roberts if (i) there has been a breach in any material
     respect (except that where any statement in a representation or warranty
     includes a standard of materiality, such statement shall be true and
     correct in all respects giving effect to such standard) of any
     representation, warranty, covenant or agreement on the part of Roberts set
     forth in this Agreement which breach is not curable on or prior to December
     31, 1999 or (ii) the Board of Directors of Roberts (x) fails to recommend
     the approval of this Agreement and the Merger to Roberts' shareholders in
     accordance with Section 8.2 hereof, or (y) withdraws or amends or modifies
     in a manner adverse to Shire its recommendation or approval in respect of
     this Agreement or the Merger or fails to reconfirm such recommendation
     within 5 business days of a reasonable written request for such
     confirmation by Shire;

          (e) by the Board of Directors of Shire if they shall reasonably
     determine that a proposal for a Shire Acquisition Transaction constitutes a
     Shire Superior Proposal; provided, however, that Shire may not terminate
     this Agreement pursuant to this clause (e) unless (i) 5 business days shall
     have elapsed after delivery to Roberts of a written notice of such
     determination by such Board of Directors and, during such 5-business-day
     period, Shire shall have informed Roberts of the material terms and
     conditions and financing arrangements of such proposal for a Shire
     Acquisition Transaction and the identity of the person or group making such
     proposal for a Shire Acquisition Transaction and (ii) at the end of such
     5-business-day period, such Board of Directors shall continue reasonably to
     believe that such proposal for a Shire Acquisition Transaction constitutes
     a Shire Superior Proposal and promptly thereafter Shire shall enter into a
     definitive acquisition, merger or similar agreement to effect such Shire
     Superior Proposal;

          (f) by action of the Board of Directors of Roberts and notice thereof
     given in writing to Shire if (i) there is a breach in any material respect
     (except that where any




<PAGE>
                                      -72-


     statement in a representation or warranty includes a standard of
     materiality, such statement shall be true and correct in all respects
     giving effect to such standard) of any representation, warranty, covenant
     or agreement on the part of Shire or Acquisition Sub set forth in this
     Agreement which breach is not curable on or prior to December 31, 1999 or
     (ii) the Board of Directors of Shire (x) fails to recommend the approval of
     this Agreement and the Merger to Shire's shareholders in accordance with
     Section 8.3 hereof, or (y) withdraws or amends or modifies in a manner
     adverse to Roberts its recommendation or approval in respect of this
     Agreement or the Merger or fails to reconfirm such recommendation within 5
     business days of a reasonable written request for such confirmation by
     Roberts; or

          (g) by the Board of Directors of Roberts if they shall reasonably
     determine that a proposal for a Roberts Acquisition Transaction constitutes
     a Roberts Superior Proposal; provided, however, that Roberts may not
     terminate this Agreement pursuant to this clause (g) unless (i) 5 business
     days shall have elapsed after delivery to Shire of a written notice of such
     determination by such Board of Directors and, during such 5-business-day
     period, Roberts shall have informed Shire of the material terms and
     conditions and financing arrangements of such proposal for a Roberts
     Acquisition Transaction and the identity of the person or group making such
     proposal for a Roberts Acquisition Transaction and (ii) at the end of such
     5-day-business period, such Board of Directors shall continue reasonably to
     believe that such proposal for a Roberts Acquisition Transaction
     constitutes a Roberts Superior Proposal and promptly thereafter Roberts
     shall enter into a definitive acquisition, merger or similar agreement to
     effect such Roberts Superior Proposal.

     9.2. Effect of Termination. In the event of termination of this Agreement
as provided in Section 9.1, this Agreement shall forthwith become void and have
no effect and there shall be no liability or obligation on the part of Shire,
Roberts, Acquisition Sub or any their respective officers or directors other
than provisions of the last sentence of Section 4.4, the last sentence of
Section 5.4, Section 10.9, Section 10.10 and this Section 9.2, which will
survive termination and except to the extent that such termination results from
the willful and material breach by a party of any of its representations,
warranties, covenants or agreements set forth in this Agreement.




<PAGE>
                                      -73-


     (b) If (x) Shire shall have terminated this Agreement pursuant to Section
9.1(d)(ii) or (y) Roberts shall have terminated this Agreement pursuant to
Section 9.1(g), or (z) Shire or Roberts shall have terminated this Agreement
pursuant to Sections 9.1(b)(ii) or (c)(y) following the public announcement
(other than by Shire or any of its affiliates) of a proposal for a Roberts
Acquisition Transaction by any person (other than the transactions contemplated
by this Agreement) and such termination was not solely the result of any action
or inaction by Shire which resulted in the failure of the conditions in Section
7.1(a), (b) or (c) or Section 7.2, and, prior to or within six months after any
termination described in this clause (z), Roberts (or any of its Subsidiaries)
shall have entered into a definitive agreement for, or shall have consummated, a
Roberts Acquisition Transaction, in which the consideration received by Roberts
or its shareholders is equal to or greater than the value of the Merger
Consideration on the date of this Agreement then, in any of such cases, Roberts
shall pay Shire a termination fee of $30.0 million, provided, however, no fee
shall be payable pursuant to this Section 9.2(b) if at the time of termination
of this Agreement pursuant to Section 7.1(a) either (aa) the waiting period
under the HSR Act (including any voluntary extension or such period) shall not
have expired or (bb) any governmental entity is asserting an objection under
applicable antitrust laws to the transactions contemplated by this Agreement or
(cc) a Final Order has been issued and remains outstanding. Any fee payable
under this Section 9.2(b) shall be paid in same day funds (A) contemporaneous
with a termination described in either clause (x) or (y) of this Section 9.2(b),
and no notice of termination pursuant to such sections shall be effective and
this Agreement shall not terminate, until such termination fee is received by
Shire, or (B) concurrently with or prior to the entering into of the definitive
agreement for, or the consummation of, such Roberts Acquisition Transaction, in
the case of a termination described in clause (z) of this Section 9.2(b).

     (c) If (x) Roberts shall have terminated this Agreement pursuant to Section
9.1(f)(ii) or (y) Shire shall have terminated this Agreement pursuant to Section
9.1(e), or (z) Shire or Roberts shall have terminated this Agreement pursuant to
Sections 9.1(b)(ii) or (c)(x) following the public announcement (other than by
Roberts or any of its affiliates) of a proposal for a Shire Acquisition
Transaction by any person (other than the transactions contemplated by this
Agreement) and such termination was not solely the result of any action or
inaction by Roberts which resulted in the failure of the conditions in Section
7.1(a), (b) or (c) or Section 7.3, and, prior to or



<PAGE>
                                      -74-


within six months after any termination described in this clause (z), Shire (or
any of its Subsidiaries) shall have entered into a definitive agreement for, or
shall have consummated, a Shire Acquisition Transaction, then, in any of such
cases, Shire shall pay Roberts a termination fee of $30.0 million, provided,
however, no fee shall be payable pursuant to this Section 9.2(c) if at the time
of termination of this Agreement pursuant to Section 7.1(a) either (aa) the
waiting period under the HSR Act (including any voluntary extension or such
period) shall not have expired or (bb) any governmental entity is asserting an
objection under applicable antitrust laws to the transactions contemplated by
this Agreement or (cc) a Final Order has been issued and remains outstanding.
Any fee payable under this Section 9.2(c) shall be paid in same day funds (A)
contemporaneous with a termination described in either clause (x) or (y) of this
Section 9.2(c), and no notice of termination pursuant to such sections shall be
effective and this Agreement shall not terminate, until such termination fee is
received by Roberts, or (B) concurrently with or prior to the entering into of
the definitive agreement for, or the consummation of, such Shire Acquisition
Transaction, in the case of a termination described in clause (z) of this
Section 9.2(c).

     9.3. Amendment. This Agreement may be amended by the parties hereto at any
time before or after any required approval of matters presented in connection
with the Merger by the shareholders of Roberts or the shareholders of Shire;
provided, however, that after any such approval, there shall be made no
amendment that by law requires further approval by such shareholders without the
further approval of such shareholders. This Agreement may be amended by an
instrument in writing signed on behalf of each of the parties hereto.

     9.4. Waiver. At any time prior to the Closing, any party may (a) extend the
time for the performance of any of the obligations or other acts of any other
party hereto, (b) waive any inaccuracies in the representations and warranties
contained in this Agreement or in any document delivered pursuant to this
Agreement or (c) subject to the proviso of Section 9.3, waive compliance with
any of the agreements of any other party or with any conditions to its own
obligations. Except as otherwise required by law, (x) any agreement on the part
of a party hereto to any such extension or waiver shall be valid only if set
forth in an instrument in writing signed by or on behalf of such party by a duly
authorized signatory and (y) the failure of any party to this Agreement to
assert any of its



<PAGE>
                                      -75-


rights under this Agreement or otherwise shall not constitute a waiver of those
rights.

                                    ARTICLE X

                               GENERAL PROVISIONS

     10.1. Public Statements. Each of Shire and Acquisition Sub, on the one
hand, and Roberts, on the other hand, agree that neither they nor their
respective directors, officers, employees or agents shall disclose to any third
party (other than to their professional advisers) or publicly issue any press
release or other statement to the press or any third party with respect to this
Agreement or transactions contemplated hereby, except as may be required by law
or the rules of the American Stock Exchange or LSE rule, without the consent of
the other parties hereto.

     10.2. Notices. All notices and other communications hereunder shall be in
writing (including telex or similar writing) and shall be deemed given if
delivered in person or by messenger, cable, telegram or telex or facsimile
transmission or by a reputable overnight delivery service which provides for
evidence of receipt to the parties at the following addresses or telecopier
numbers (or at such other address or telecopy number for a party as shall be
specified by like notice):

            (a)  if to Shire or Acquisition Sub, to:

                     Shire Pharmaceuticals Group plc
                     East Anton
                     Andover, Hants  SP10 5RG
                     United Kingdom
                     Telecopy:  011 44 1 264 334 658
                     Attention:  Rolf Stahel, Chief Executive

                     with a copy to:

                     John P. Mitchell, Esq.
                     Cahill Gordon & Reindel
                     80 Pine Street
                     New York, New York  10005
                     USA
                     Telephone:  (212) 701-3000
                     Telecopy:  (212) 269-5420



<PAGE>
                                      -76-


            (b)  if to Roberts, to:

                     Roberts Pharmaceutical Corporation
                     Meridian Center II
                     4 Industrial Way West
                     Eatontown, NJ  07724
                     Telecopy:  (732) 676-1300
                     Attention:  General Counsel

                     with a copy to:

                     Lawrence Lederman, Esq.
                     Milbank, Tweed, Hadley & McCloy LLP
                     One Chase Manhattan Plaza
                     New York, New York  10005
                     USA
                     Telecopy:  (212) 530-5219

     10.3. Interpretation. When reference is made in this Agreement to a
Subsection, Section, Exhibit or Schedule, such reference is to a Subsection or
Section of or an Exhibit or Schedule to, this Agreement unless otherwise
indicated. The table of contents and headings contained in this Agreement are
for reference purposes only and shall not affect in any way the meaning or
interpretation of this Agreement. Whenever the words "include", "includes" and
"including" are used in this Agreement, they are deemed to be followed by the
words "without limitation". For all purposes of this Agreement, except as
otherwise expressly provided or unless the context otherwise requires, (i) the
terms defined include the plural as well as the singular, (ii) all accounting
terms not otherwise defined herein have the meanings assigned under United
States generally accepted accounting principles, and (ii) the words "herein,"
"hereof" and "hereunder" and other words of similar import refer to this
Agreement as a whole and not to any particular Article, Section, Subsection or
other subdivision.

     10.4. Counterparts. This Agreement may be executed in one or more
counterparts, all of which shall be considered one and the same agreement and
shall become effective when one or more counterparts have been signed by each of
the parties and delivered to the other parties, it being understood that all
parties need not sign the same counterpart.

     10.5. Entire Agreement. This Agreement (including the Exhibits and
Schedules hereto) constitute the entire agreement and supersede all prior
agreements and understandings, both written and oral, among the parties with
respect to the




<PAGE>
                                      -77-


subject matter hereof; provided that the Confidentiality Agreements referred to
in Sections 4.4 and 5.4 hereof shall survive the termination of this Agreement
in accordance with their terms.

     10.6. Governing Law. Except where by its terms New Jersey Law is governing,
this Agreement shall be governed by and construed in accordance with the laws of
the State of New York, without regard to the principles of conflicts of law of
such state.

     10.7. Validity. The invalidity or unenforceability of any provision of this
Agreement shall not affect the validity or enforceability of any other provision
of this Agreement, each of which shall remain in full force and effect.

     10.8. Assignment. Neither this Agreement nor any of the rights, interests
or obligations hereunder shall be assigned by any party hereto, whether by
operation of law or otherwise, without the express prior written consent of each
of the other parties hereto. Subject to the preceding sentence, this Agreement
will be binding upon, inure to the benefit of and be enforceable by the parties
and their respective successors.

     10.9. Expenses. Except as otherwise expressly provided herein, each party
shall bear its own expenses incurred in connection with the transactions
contemplated by this Agreement.

     10.10. Enforcement. The parties agree that irreparable damage would occur
in the event that any of the provisions of this Agreement were not performed in
accordance with their specific terms or were otherwise breached. The parties
accordingly agree that the parties will be entitled to an injunction or
injunctions to prevent breaches of this Agreement and to enforce specifically
the terms and provisions of this Agreement in any court of the United States
located in the State of New York, Borough of Manhattan, or in New York state
court located in the Borough of Manhattan, this being in addition to any other
remedy to which they are entitled at law or in equity. In addition, each of the
parties hereto (i) consents to submit itself to the personal jurisdiction of any
Federal court located in the State of New York, Borough of Manhattan, or any New
York state court located in the Borough of Manhattan if any dispute arises out
of the Agreement or any of the transactions contemplated by this Agreement, (ii)
agrees that it will not attempt to deny or defeat such personal jurisdic-




<PAGE>
                                      -78-


tion by motion or other request for leave from any such court and (iii) agrees
that it will not bring any action relating to this Agreement in any court other
than such a Federal or state court sitting in the State of New York located in
the Borough of Manhattan.



<PAGE>
                                      -79-


     IN WITNESS WHEREOF, Shire, Acquisition Sub and Roberts have caused this
Agreement to be executed and delivered by their respective duly authorized
officers, all as of the date first above written.

                                SHIRE PHARMACEUTICALS GROUP PLC


                                By: /s/ Rolf Stahel
                                    -----------------------------------------
                                    Name:   Rolf Stahel
                                    Title:  Chief Executive Officer


                               RUBY ACQUISITION SUB INC.


                               By: /s/ Rolf Stahel
                                   ------------------------------------------
                                    Name:   Rolf Stahel
                                    Title:  President


                               ROBERTS PHARMACEUTICAL CORPORATION


                               By: /s/ John T. Spitznagel
                                   ------------------------------------------
                                   Name:   John T. Spitznagel
                                   Title:  President-Chief Executive Officer


<PAGE>



                                   Schedule 1
             Entities Required to Execute the Shareholder Agreement


1A

Yamanouchi Holdings Corp.
Robert Vukovich

1B

HealthCare  Ventures II, L.P.
HealthCare Ventures III, L.P.
HealthCare Ventures IV, L.P.
HealthCare Ventures V, L.P.



<PAGE>



                                  Schedule 2-A
                          Knowledge Officers of Roberts


                               John T. Spitznagel

                                  Robert W. Loy

                                  Pert Rogalin

                                 Anthony Rascio

                                Louis P. Berardi

                                David S. Tierney





<PAGE>

                                  Schedule 2-B
                           Knowledge Officers of Shire


                                   Rolf Stahel

                                  Stephen Stamp

                                 William Nuerge

                                  Jack Khattar

                                   Neil Harris





<PAGE>

                                  Schedule 3-A
                        Officers of Surviving Corporation


                  Officers of Roberts unless otherwise agreed



<PAGE>

                                  Schedule 3-B
                       Directors of Surviving Corporation

                  Directors of Acquisition Sub unless otherwise agreed



                                OPTION AGREEMENT


         OPTION AGREEMENT (this  "Agreement"),  dated as of July 26, 1999 by and
between   Roberts   Pharmaceutical   Corporation,   a  New  Jersey   corporation
("Roberts"),  and Shire  Pharmaceuticals  Group  plc, a public  limited  company
organized under the laws of England and Wales ("Shire").

         WHEREAS,  concurrently  herewith,  Shire,  Roberts and Ruby Acquisition
Sub,  a New  Jersey  corporation  ("Acquisition  Sub"),  are  entering  into  an
Agreement  and Plan of Merger of even date  herewith  (the "Merger  Agreement"),
pursuant  to which  Acquisition  Sub will  merge  with  and  into  Roberts  (the
"Merger"); and

         WHEREAS,  as a condition and inducement to Shire and Acquisition Sub to
enter into the Merger  Agreement,  Shire has required  that Roberts  agree,  and
Roberts has agreed, to grant to Shire an option to purchase certain newly issued
shares of  common  stock,  par value  $.01 per share  (the  "Common  Stock")  of
Roberts, upon the terms and conditions set forth herein;

         NOW, THEREFORE, in consideration of the mutual covenants and agreements
herein contained and other good and valuable consideration,  and intending to be
legally bound hereby, it is agreed as follows:

1.   Option to Purchase.

         1.1 Grant of  Option.  Roberts  hereby  grants to Shire an  irrevocable
option (the  "Option") to purchase up to  6,345,926  shares of Common Stock (the
"Shares")  on the terms and  subject to the  conditions  set forth  herein.  The
Option is  exercisable  upon the occurrence of any event causing the payment set
forth in Section 9.2(b) of the Merger Agreement to become due and payable.

         1.2  Exercise of Option.  Subject to Section  1.1, at any time prior to
the termination of this Agreement, Shire may exercise the Option, in whole or in
part, by sending a written  notice of such exercise (the  "Exercise  Notice") to
Roberts  specifying  the number of Shares to be  purchased  and a date (not less
than two  business  days nor more  than ten days  from the later of (i) the date
such  Exercise  Notice is given and (ii) the  expiration or  termination  of any
waiting period,  and any extensions  thereof,  under the HSR Act (as hereinafter
defined))




<PAGE>
                                      -2-


(the "Option  Closing  Date") for the closing of such purchase (the  "Closing").
The Option may only be exercised on one  occasion.  The Closing shall take place
at the offices of Cahill Gordon & Reindel,  80 Pine Street,  New York, New York,
at 11:00 a.m.,  local time, on the day specified in such notice or at such other
place,  and at such other time or date, as the parties hereto may agree.  At the
Closing,  Roberts  shall  deliver  to  Shire  certificates  in  definitive  form
representing the number of Shares specified in the Exercise Notice registered in
the name of Shire or its  designee,  against  payment  therefor as  specified in
Section 1.3. All applicable  transfer and documentary taxes and other fees shall
be paid by Roberts.

         1.3 Purchase Price. The purchase and sale of the shares of Common Stock
pursuant to Section 1.1 of this Agreement shall be at a purchase price per share
equal to $30.00 in cash (the "Purchase Price"). At the Closing,  Shire shall pay
to Roberts in immediately  available funds by wire transfer payable to the order
of Roberts an amount equal to the product of the Purchase  Price  multiplied  by
the number of Shares sold pursuant to this Section 1.

         1.4 Adjustments.  If at any time the outstanding shares of Common Stock
are changed into a different  number of shares or a different class by reason of
any  reclassification,  recapitalization,  split-up,  combination,  exchange  of
shares or readjustment or if a stock dividend  thereon is declared with a record
date prior to the  termination of this  Agreement,  then the number of shares of
Common Stock subject to the Option and the applicable per share consideration to
be paid by Shire upon exercise of the Option (but not the total purchase  price)
shall be appropriately  and equitably  adjusted so that Shire shall receive upon
exercise  of the Option the  number and class of shares or other  securities  or
property  that Shire  would have  received  in respect of the Shares  that Shire
would have been  entitled to purchase  upon exercise of the Option if the Option
had been exercised  immediately  prior to such event.  The rights of Shire under
this Section 1.4 shall be in addition to, and shall in no way limit,  its rights
against Roberts for breach by Roberts of the Merger Agreement.

         1.5 Aggregate Limits. (a)  Notwithstanding  any other provision of this
Agreement or the Merger  Agreement,  in no event shall  Shire's Total Profit (as
hereinafter  defined) exceed in the aggregate $32.0 million and, if it otherwise
would exceed such amount Shire, in its sole discretion,  shall either (i) reduce
the number of shares of Common  Stock  subject to the  Option,  (ii) pay cash to
Roberts, (iii) reduce the fee



<PAGE>
                                      -3-


set forth in Section  9.2(b) of the  Merger  Agreement  or (iv) any  combination
thereof,  so that Shire's actually realized Total Profit shall not exceed in the
aggregate $32.0 million after taking into account the foregoing actions.

         (b) Notwithstanding any other provision of this Agreement,  this Option
may not be  exercised  for a  number  of  Shares  as  would,  as of the date the
Exercise  Notice is given,  result in a Notional Total Profit (as defined below)
of more than $32.0 million and, if exercise of the Option otherwise would exceed
such amount, Shire, at its discretion,  may increase the Purchase Price for that
number of Shares set forth in the  Exercise  Notice so that the  Notional  Total
Profit shall not exceed $32.0 million.

         (c) As used  herein,  the term  "Total  Profit"  shall  mean the sum of
(i)(x) the amount (before taxes but net of reasonable and customary  commissions
paid or payable in connection with such transaction)  received by Shire pursuant
to the sale or other  disposition  of the Shares less (y) the exercise price for
such Shares,  (ii) any amounts (before taxes but net of reasonable and customary
commissions  paid or payable in connection  with such  transaction)  received by
Shire on the transfer of the Option (or any portion thereof) to any unaffiliated
Person(s) (if permitted  hereunder) or to Roberts and (iii) the amount  received
by Shire pursuant to Section 9.2(b) of the Merger Agreement.

         (d) As used herein,  the term  "Notional  Total Profit" with respect to
any number of Shares as to which Shire may propose to exercise this Option shall
be the  Total  Profit  determined  as of the date the  Exercise  Notice is given
assuming that this Option were  exercised on such date for such number of Shares
and assuming  that such Shares,  were sold for cash at the closing  market price
for the Common  Stock as of the close of business on the  preceding  trading day
(less customary brokerage commissions).

         2.  Representations  and Warranties of Roberts.  Roberts represents and
warrants to Shire as follows:

         2.1 Shares of Common Stock.  Roberts has taken all action  necessary to
authorize  and reserve for issuance and to permit it to issue,  upon exercise of
the Option,  and at all times from the date hereof through the expiration of the
Option will have  reserved,  that number of unissued  Shares that are subject to
the Option, all of which, upon their issuance and



<PAGE>
                                      -4-


delivery in accordance with the terms of this Agreement, will be validly issued,
fully  paid and  nonassessable.  Upon  delivery  of the Shares to Shire upon the
exercise  of the  Option,  Shire will  acquire  the  Shares,  free of all liens,
encumbrances,  restrictions and claims of every kind other than  restrictions on
transfer under applicable Federal and State securities laws.

         2.2  Authority;  Binding  Agreement.  Roberts has the full legal right,
power and authority to enter into and perform all of its obligations  under this
Agreement.  The  execution  and  delivery of this  Agreement by Roberts will not
violate its  Certificate of  Incorporation  or By-laws.  This Agreement has been
duly  executed  and  delivered  by Roberts and  constitutes  a legal,  valid and
binding agreement of Roberts,  enforceable in accordance with its terms,  except
as  the   enforcement   thereof  may  be  limited  by  bankruptcy,   insolvency,
reorganization,  moratorium  and  similar  laws,  now  or  hereafter  in  effect
affecting  creditors'  rights and remedies  generally or general  principles  of
equity.   Neither  the  execution  and  delivery  of  this   Agreement  nor  the
consummation  by  Roberts  of the  transactions  contemplated  hereby  will  (i)
violate, or require any consent,  approval or notice under, any provision of any
judgment,  order, decree, statute, law, rule or regulation applicable to Roberts
or the  Shares,  except for the  filings  required  under the  Hart-Scott-Rodino
Antitrust  Improvements  Act of  1976,  as  amended  (the  "HSR  Act"),  or (ii)
constitute a violation  of,  conflict with or  constitute a default  under,  any
material contract, commitment,  agreement,  understanding,  arrangement or other
restriction of any kind to which Roberts and its  subsidiaries are a party or by
which any of them are bound.

         2.3 No Consent. The execution and delivery of this Agreement by Roberts
does not, and the performance of this Agreement by Roberts will not, require any
consent,  approval,  authorization  or permit of, or filing with or notification
to, any non-governmental entity or other third party.

         2.4 Reliance on Agreement.  Roberts  understands and acknowledges  that
Shire is entering into the Merger Agreement in reliance upon Roberts'  execution
and delivery of this Agreement.  Roberts acknowledges that the irrevocable stock
option set forth in Section 1 is granted in consideration  for the execution and
delivery of the Merger Agreement by Shire.




<PAGE>
                                      -5-


3.  Representations  and Warranties of Shire.  Shire  represents and warrants to
Roberts as follows:

         3.1 Authority; Binding Agreement. Shire has full legal right, power and
authority to enter into and perform all of its obligations under this Agreement.
This  Agreement has been duly executed and delivered by Shire and  constitutes a
legal, valid and binding agreement of Shire,  enforceable in accordance with its
terms,  except  as  the  enforcement  thereof  may  be  limited  by  bankruptcy,
insolvency,  reorganization,  moratorium  and similar laws,  now or hereafter in
effect,  affecting creditors rights and remedies generally or general principles
of  equity.  Neither  the  execution  and  delivery  of this  Agreement  nor the
consummation by Shire of the transactions  contemplated hereby will (i) violate,
or require any consent, approval or notice under, any provision of any judgment,
order,  decree,  statute,  law,  rule or  regulation  applicable to Shire or the
Shares,  except for the filings under the HSR Act or (ii) constitute a violation
of,  conflict with or  constitute a default  under,  any  contract,  commitment,
agreement, understanding,  arrangement or other restriction of any kind to which
Shire is a party or by which it is bound.

         3.2 Private  Purchase.  Shire is acquiring  the Option and will acquire
the shares of Common  Stock upon the  exercise of the Option for its own account
and not with a view to the  distribution  or resale thereof in any manner not in
accordance with applicable law.

4.   Certain Covenants of Roberts.

         4.1 HSR Act. If prior  notification to or approval of any regulatory or
antitrust agency is required in connection with the acquisition of the Shares by
Shire  hereunder,  Roberts shall  promptly make any required  filing,  and shall
expeditiously  respond to any requests and make any subsequent filings necessary
to  obtain  clearance  to  consummate  the  purchase  of the  Shares  by  Shire.
Notwithstanding  Section 1, the time periods specified therein shall run instead
from the date on which any  required  notification  periods have expired or been
terminated or such approvals have been obtained and any requisite waiting period
or periods shall have passed.




<PAGE>
                                      -6-


5.   Certain Covenants of Shire.

         5.1  Voting.  Subject to payment  by Roberts of all  amounts  due Shire
under  Section  9.2(b)  of the  Merger  Agreement  (subject  to the  limitations
contained in Section 1.5 hereof),  Shire will vote any Shares then held by it in
favor of the first  Roberts  Acquisition  Transaction  (as defined in the Merger
Agreement)  recommended  by Roberts'  Board of Directors  subsequent  to Shire's
exercise  of the  Option,  provided  that  such,  recommendation  has  not  been
withdrawn,  amended or modified.  Shire will be present in person or represented
by proxy at each shareholder meeting of which it receives notice,  provided such
notice is given in compliance  with Roberts'  Certificate of  Incorporation  and
By-Laws and New Jersey law or Shire waives such notice.

         5.2 Standstill.

         Shire  agrees that for a period of two years from the date of the first
exercise of the Option,  neither it nor any of its affiliates will,  without the
prior written consent of Roberts or its Board of Directors:

          (a)  acquire,  offer to acquire,  or agree to acquire,  by purchase or
               otherwise,  voting  securities  or direct or  indirect  rights to
               acquire any voting securities of Roberts,  or of any successor to
               or person in control of Roberts  representing in excess of 20% of
               the  then  outstanding  voting  equity  of  such  entity,  or any
               material  portion of the assets of Roberts or any  subsidiary  or
               division thereof or of any such successor or controlling person;

          (b)  make, or in any way participate,  directly or indirectly,  in any
               "solicitation"  of  "proxies"  to vote (as such terms are used in
               the rules of the Securities and Exchange Commission),  or seek to
               advise or influence  any person with respect to the voting of any
               voting securities of the Roberts which Shire does not then own;

          (c)  make  any  public  announcement  with  respect  to,  or  submit a
               proposal  for,  or  offer of (with  or  without  conditions)  any
               Roberts Acquisition Transaction; or

          (d)  form,  join or in any way  participate in a "group" as defined in
               Section  13(d)(3)  of the  Securities  Exchange  Act of 1934,  as
               amended (the "Exchange Act"),



<PAGE>
                                      -7-


               or enter into  discussions with any  person other  than  Roberts,
               in  connection with any of the foregoing.

         Notwithstanding  the foregoing,  paragraphs (a) through (d) above shall
not be  binding on Shire if,  without  the  appraisal  of the  Roberts  board of
directors, (A) any person or group of person (other than any person specified in
Rule 13d-1(b)(1)(i) and (ii) under the Exchange Act or Shire and its affiliates)
acquires  beneficial  ownership of Common Stock,  or any securities  convertible
into or  exchangeable  for any Common Stock (or any  combination of Common Stock
and such  securities),  representing  10% or more of the then total  outstanding
shares of Common  Stock;  or (B) it has been  publicly  announced  or  otherwise
publicly disclosed that any person or group of persons,  other than Shire or any
of  its   affiliates,   proposes  to  effect  or  has  effected  (1)  a  merger,
consolidation or other business  combination  transaction with Roberts,  (2) any
sale, lease, exchange, transfer or other disposition of all or substantially all
of the assets of Roberts and its  subsidiaries,  taken as a whole,  (3) a tender
offer or exchange  offer for more than 10% of the  outstanding  shares of Common
Stock, or (4) any solicitation of proxies with respect to shares of Common Stock
by any person or group of persons  (other  than Shire or any of its  affiliates)
with  respect  to either  the  election  of the  directors  or  relating  to any
transaction of the kind referred to in this paragraph.

         5.3   Transfer   Restrictions.   For  so  long  as  Shire  owns  Shares
representing at least 5% of the outstanding shares of Common Stock, Shire agrees
that it will not sell, transfer any beneficial interest in, pledge,  hypothecate
or otherwise dispose of any Shares at any time except as follows:

          (i)  pursuant  to a Roberts  Acquisition  Transaction  approved by the
               board of directors of Roberts; or

          (ii) in compliance  with Rule 144 (or any successor  provision)  under
               the Securities Act of 1933, as amended.

6.  Termination.  This  Agreement,  to the  extent an  Exercise  Notice  has not
previously been given after the occurrence of the event described in Section 1.1
hereof,  shall terminate on the earlier of (i) the Effective Time (as defined in
the  Merger  Agreement)  or (ii) the  termination  of the  Merger  Agreement  in
accordance  with its terms  unless a fee is payable  or could be  payable  under
Section  9.2(b) of the  Merger  Agreement  (in which




<PAGE>
                                      -8-


case this Agreement  shall terminate one business day after any amount due under
such  Section  9.2(b)  has been  received  by Shire or a fee  could no longer be
payable under the terms of such Section 9.2(b)).

7. Restrictive  Legends.  Each certificate  representing  Shares issued to Shire
hereunder shall, to the extent applicable, include a legend in substantially the
following form:

          THE  SECURITIES   REPRESENTED  BY  THIS   CERTIFICATE  HAVE  NOT  BEEN
     REGISTERED  UNDER  THE  SECURITIES  ACT OF  1933,  AS  AMENDED,  AND MAY BE
     REOFFERED  OR SOLD  ONLY IF SO  REGISTERED  OR IF AN  EXEMPTION  FROM  SUCH
     REGISTRATION  IS  AVAILABLE.   THESE  SECURITIES  ARE  SUBJECT  TO  CERTAIN
     RESTRICTIONS CONTAINED IN AN OPTION AGREEMENT DATED AS OF JULY 23, 1999.

8.  Conditions to Closing.  The  obligations  of the parties to close  hereunder
shall be subject to the  conditions  that (i) there shall be no  preliminary  or
permanent   injunction   or  other  order  issued  by  any  court  of  competent
jurisdiction  in effect which  prohibits the issuance of the Shares and (ii) all
applicable waiting periods, and any extensions thereof,  under the HSR Act shall
have expired or been terminated.  Roberts agrees not to seek any such injunction
or order and agrees that it will oppose and will seek the  immediate  lifting of
any such injunction or order.

9.   Miscellaneous.

         9.1 Survival of Representations  and Warranties.  All  representations,
warranties, covenants and agreements made by Roberts and Shire in this Agreement
shall survive any Closing hereunder and any investigation at any time made by or
on behalf of any party.

         9.2  Notices.  All  notices,   requests,   claims,  demands  and  other
communications  under this Agreement  shall be in writing and shall be delivered
personally or by next-day courier or telecopied with confirmation of receipt, to
the parties at the  addresses  specified  below (or at such other  address for a
party as shall be specified by like notice; provided that notices of a change of
address shall be effective only upon receipt thereof).  Any such notice shall be
effective upon receipt, if




<PAGE>
                                      -9-


personally delivered or telecopied or one day after delivery to a courier for
next-day delivery.

           If to Shire:

           Shire Pharmaceuticals Group plc
           East Anton
           Andover, Hants SP 10 5RG
           United Kingdom
           Telecopy:  011 44 1 264 334 658
           Attention:  Rolf Stahel, Chief Executive Officer

           with copies to:

           John P. Mitchell, Esq.
           Cahill Gordon & Reindel
           80 Pine Street
           New York, NY  10005
           Telephone:  (212) 701-3000
           Telecopy:   (212) 269-5420

           If to Roberts:

           Roberts Pharmaceutical Corporation
           Four Industrial Way West
           Eatontown, New Jersey  07724-2274

           with a copy to:

           Lawrence Lederman, Esq.
           Milbank, Tweed, Hadley & McCloy LLP
           One Chase Manhattan Plaza
           New York, NY  10005
           Telephone:  (212) 530-5000
           Telecopy:   (212) 530-5219

         9.3 Entire  Agreement.  This  Agreement,  together  with the  documents
expressly referred to herein,  constitute the entire agreement and supersede all
other prior agreements and  understandings,  both written and oral,  between the
parties, with respect to the subject matter contained herein.

         9.4 Amendments. This Agreement may not be modified, amended, altered or
supplemented,  except upon the  execution  and  delivery of a written  agreement
executed by the parties hereto.

         9.5  Assignment.  This Agreement shall be binding upon and inure to the
benefit of the  parties  hereto and their  respective  successors,  assigns  and
personal  representatives,  but neither  this  Agreement  nor any of the rights,
interests or


<PAGE>
                                      -10-


obligations hereunder shall be assigned by any of the parties hereto without the
prior written consent of the other party.

         9.6  Expenses.  Each  party  hereto  will  pay all of its  expenses  in
connection with the  transactions  contemplated  by this  Agreement,  including,
without limitation, the fees and expenses of its counsel and other advisers.

         9.7 Governing Law. This  Agreement,  and all matters  relating  hereto,
shall be governed by, and construed in accordance  with the laws of the State of
New York without giving effect to the principles of conflicts of laws thereof.

         9.8 Injunctive  Relief;  Jurisdiction.  Roberts agrees that irreparable
damage would occur and that Shire would not have any  adequate  remedy at law in
the event that any of the  provisions  of this  Agreement  were not performed in
accordance  with  their  specific  terms  or  were  otherwise  breached.  It  is
accordingly  agreed that Shire shall be entitled to an injunction or injunctions
to prevent breaches by Roberts of this Agreement and to enforce specifically the
terms and provisions of this Agreement in any court of the United States located
in the State of New York,  Borough  of  Manhattan,  or in New York  state  court
located in the Borough of Manhattan,  this being in addition to any other remedy
to which they are entitled at law or in equity. In addition, each of the parties
hereto (i)  consents to submit such party to the  personal  jurisdiction  of any
Federal court  located in the State of New York,  Borough of Manhattan or in New
York State Court  located in the Borough of  Manhattan  in the event any dispute
arises out of this  Agreement or any of the  transactions  contemplated  hereby,
(ii) agrees that such party will not attempt to deny or defeat such party to the
personal  jurisdiction  by motion or other request for leave from any such court
and (iii)  agrees  that such party will not bring any  action  relating  to this
Agreement or any of the transactions contemplated hereby in any court other than
a Federal  or state  court  sitting  in the State of New  York,  located  in the
Borough of Manhattan.

         9.9  Counterparts.  This  Agreement  may be  executed  in any number of
counterparts,  each of which shall be deemed to be an original  and all of which
together shall constitute one and the same document.

         9.10  Descriptive  Headings.  The descriptive  headings used herein are
inserted for convenience of reference only and are not intended to be part of or
to affect the meaning or interpretation of this Agreement.




<PAGE>
                                      -11-


         9.11  Severability.  Any term or provision of this  Agreement  which is
invalid or unenforceable in any jurisdiction shall, as to such jurisdiction,  be
ineffective  to the  extent  of  such  invalidity  or  unenforceability  without
rendering  invalid or  unenforceable  the remaining terms and provisions of this
Agreement or affecting  the  validity or  enforceability  of any of the terms or
provisions of this Agreement in any other jurisdiction. If any provision of this
Agreement  is  so  broad  as  to  be  unenforceable,  such  provision  shall  be
interpreted to be only so broad as is enforceable.

         9.12 Further  Assurances.  Each party hereto shall  execute and deliver
such  additional  documents as may be necessary or desirable to  consummate  the
transactions contemplated by this Agreement.

         9.13 Third-Party Beneficiaries. Nothing in this Agreement, expressed or
implied, shall be construed to give any person other than the parties hereto any
legal or equitable  right,  remedy or claim under or by reason of this Agreement
or any provision contained herein.




<PAGE>
                                      -12-


     IN WITNESS WHEREOF, Shire and Roberts have caused this Agreement to be
executed by their duly authorized officers, as of the date and year first above
written.


                               SHIRE PHARMACEUTICALS GROUP PLC


                               By:   /s/ Rolf Stahel
                                     -----------------------------------------
                                     Name:   Rolf Stahel
                                     Title:  Chief Executive Officer


                               ROBERTS PHARMACEUTICAL CORPORATION


                               By:   /s/ John T. Spitznagel
                                     -----------------------------------------
                                     Name:   John T. Spitznagel
                                     Title:  President-Chief Executive Officer







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