INTERNEURON PHARMACEUTICALS INC
8-K, 1997-02-18
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                             ----------------------

                       Pursuant to Section 13 or 15(d) of
                        the Securities Exchange Act 1934

                             ----------------------


                       Date of Report: February 18, 1997



                        INTERNEURON PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------
               (Exact name of registrant as specified in charter)


                                    DELAWARE
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                 (State of other jurisdiction of incorporation)


         0-18728                                           043047911
- -------------------------                      ---------------------------------
(Commission File Number)                       (IRS Employer Identification No.)


One Ledgemont Center, 99 Hayden Avenue, Lexington, Massachusetts         02173
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(Address of principal executive offices)                              (Zip Code)


         Registrant's telephone no. including area code: (617) 861-8444






ITEM 5.  OTHER EVENTS
         ------------

         On February 18, 1997, Interneuron Pharmaceuticals, Inc. (the "Company")
announced that its majority-owned subsidiary,  Progenitor,  Inc. ("Progenitor"),
agreed  to  acquire   Mercator   Genetics,   Inc.,  a   privately-held   company
("Mercator").  The  proposed  acquisition  is  subject  to  certain  conditions,
including  completion  of an initial  public  offering by Progenitor by July 31,
1997 and approval by the Mercator stockholders.  The purchase price would be $22
million,  payable in Progenitor  Common Stock,  plus the  assumption of Mercator
liabilities.  Progenitor  agreed to provide  Mercator with an interim  operating
line of credit of up to $6.6  million,  which the  Company  has  agreed to fund.
Amounts advanced under the line of credit and completion of the acquisition will
result in charges to the Company's consolidated results of operations. Reference
is made to the Company's press release dated February 18, 1997, filed as Exhibit
20.1 hereto and incorporated by reference herein.


ITEM 7.  FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS
         ------------------------------------------------------------------

         (c)      Exhibits

                  20.1     Press Release dated February 18, 1997



                                       -2-




                                   SIGNATURES


         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                       INTERNEURON PHARMACEUTICALS INC.


                                       By: /s/ Glenn L. Cooper, M.D.
                                           -------------------------------------
                                           Glenn L. Cooper, M.D.
                                           President and Chief Executive Officer

Dated:  February 18, 1997




FOR IMMEDIATE RELEASE

CONTACTS:

For Progenitor:                           For Interneuron:
Douglass B. Given, M.D., Ph.D.            William B. Boni
President and Chief Executive Officer     VP, Corp. Communications
Tel:  614-488-6688                                 Tel:  617-861-8444, ext. 606

Mark N.K. Bagnall                         For Mercator:
Vice President, Finance and                        Elliott Sigal, M.D., Ph.D.
Chief Financial Officer                   President and Chief Executive Officer
Tel: 614-488-6688                         Tel: 415-614-7030


                     PROGENITOR TO ACQUIRE MERCATOR GENETICS

                  Merged Company to Pursue Functional Genomics


LEXINGTON, MA, COLUMBUS, OH and MENLO PARK, CA, February 18, 1997 -- Interneuron
Pharmaceuticals,   Inc.  (NASDAQ:  IPIC),  Progenitor,  Inc.  (a  majority-owned
subsidiary of  Interneuron),  and Mercator  Genetics,  Inc. today announced that
Progenitor agreed to acquire Mercator,  a privately-held  genomics company.  The
acquisition  is subject to a number of  conditions,  including  completion of an
initial public offering by Progenitor.  The purchase price would be $22 million,
payable in Progenitor Common Stock, plus the assumption of Mercator liabilities.
Progenitor  also agreed to provide  Mercator with an interim  operating  line of
credit of up to $6.6 million. Funding of this line of credit will be provided by
Interneuron. Amounts advanced under the line of credit and the completion of the
acquisition  will  result in charges to the  consolidated  financial  results of
Interneuron.

Mercator is focused on the  identification  of genes  associated with cancer and
with  severe  chronic  respiratory,  inflammatory  and  neurological  disorders.
Mercator has  expertise in human  genotyping,  gene mapping and  high-throughput
sequencing.  Mercator's  principal  gene  discovery  approach,  known as disease
association, was used in its identification last year of the gene for hereditary
hemochromatosis  (iron  overload  disease).  Mercator  was formed in 1993 and is
located in Menlo Park, CA.

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"This acquisition marks progress toward Progenitor's  strategy to build, acquire
and  consolidate  technologies  and  critical  mass  in a  broad-based  genomics
business," said Douglass B. Given,  M.D.,  Ph.D.,  president and chief executive
officer  of  Progenitor.  "Mercator  furnishes  us with a new set of  tools  and
methods for  discovery  of novel genes with  functional  and medical  relevance,
additional technical expertise,  and further access to scientific leadership and
emerging  genomics  technologies.  The  integration of Mercator's  human disease
genetics  capabilities with Progenitor's core developmental  biology systems for
gene discovery and functional  characterization will create a more comprehensive
genomics platform, offering multiple approaches for discovery of candidate genes
for complex, polygenic diseases."

"Mercator has established gene discovery programs for asthma,  schizophrenia and
cancer.   Extensive  clinical  databases  and  ongoing  technology   development
distinguish our gene discovery  capabilities,"  said Elliott Sigal, M.D., Ph.D.,
president  and chief  executive  officer of Mercator.  "Progenitor's  functional
genomics will enhance the  identification  of candidate genes as well as provide
the means to demonstrate their function.  Our companies share the same vision of
how a  genomics  company  should be built and the same  management  mind-set  of
seeking out the best and most efficient genomics capabilities."

"We are excited  about the  synergies  between  developmental  biology and human
genetics," said David R. Cox, M.D., Ph.D., a Mercator  co-founder,  professor of
genetics  and  co-director  of the  Stanford  Human  Genome  Center at  Stanford
University.  "The  merger  with  Progenitor  will  result in a novel  technology
platform to discover genes and elucidate function."

"Progenitor's  acquisition of Mercator is consistent with Interneuron's goal for
its  subsidiary  companies,"  said Glenn L. Cooper,  M.D.,  president  and chief
executive  officer of Interneuron and chairman of Progenitor.  "Our subsidiaries
are building upon the initial support from Interneuron by establishing  expanded
and independent  operations and financings through corporate  alliances,  public
offerings,  mergers or other business activities,  with Interneuron retaining an
ongoing  equity  interest.  The  subsidiary  structure  provides  a  specialized
development  focus for products  and  technologies  outside the central  nervous
system field."

The  acquisition  agreement  has been  approved  by the boards of  directors  of
Progenitor  and  Mercator.  Completion  of the  transaction  is subject to other
conditions, including timing and approval by the shareholders of Mercator.

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                                      - 3 -

Dr. Given will serve as president  and chief  executive  officer of the combined
entity.  Dr. Sigal will join Progenitor in the newly created  position of senior
vice president, research and development.

There is little duplication of research functions between the two organizations.
Progenitor does not expect  significant  reduction in the Mercator work force of
39  employees.  Both  Progenitor  and Mercator have created  retention  plans to
encourage employees to remain through the reorganization. However, consolidation
of  operations  is being  considered  in order to more  quickly  and  completely
integrate programs and capabilities, and to reduce administrative costs.

Progenitor  is  a  functional   genomics   company  engaged  in  the  discovery,
characterization  and validation of novel genes,  receptors and related proteins
as therapeutic leads and targets for development and  commercialization  through
alliances with  biopharmaceutical  companies.  Progenitor's  functional genomics
approach  combines  expertise in  developmental  biology with molecular  biology
techniques and bioinformatics to accelerate the discovery process.

Interneuron  Pharmaceuticals is a diversified  biopharmaceutical company engaged
in the development and  commercialization of a portfolio of products and product
candidates  primarily for neurological and behavioral  disorders.  Interneuron's
other  subsidiaries are Intercardia,  Inc.,  focused on cardiovascular  disease;
Transcell Technologies,  Inc., focused on carbohydrate-based drug discovery; and
InterNutria, Inc., focused on dietary supplement products.

Except for the  descriptions  of historical  facts contained  herein,  this news
release contains forward-looking statements that involve risks and uncertainties
as detailed from time to time in Interneuron's  SEC filings under the Securities
Act of 1933 and the  Securities  Exchange Act of 1934,  including  the risk that
Progenitor will not complete an initial public offering of its securities.

A registration statement relating to Progenitor's securities has been filed with
the Securities and Exchange  Commission but has not yet become effective.  These
securities  may not be sold nor may offers to buy be accepted  prior to the time
the  registration  statement  becomes  effective.  This news  release  shall not
constitute  an offer to sell or the  solicitation  of an offer to buy nor  shall
there  be any sale of  these  securities  in any  state  in  which  such  offer,
solicitation or sale would be unlawful prior to  registration  or  qualification
under the securities laws of any such state.

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