INTERNEURON PHARMACEUTICALS INC
10-Q, 1997-05-15
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 10-Q
                              --------------------

[x]      QUARTERLY REPORT PURSUANT SECTION 13 or 15(d) OF THE SECURITIES
         EXCHANGE ACT  OF 1934

For the quarter ended March 31, 1997

[ ]      TRANSACTION REPORT PURSUANT TO SECTION 13 or 15(d) OF THE
         SECURITIES  EXCHANGE ACT OF 1934

For the transition period from ___________ to _____________

                              Commission File No. 0-18728

                        INTERNEURON PHARMACEUTICALS, INC.
             (exact name of registrant as specified in its charter)

Delaware                                          04-3047911
(State or other jurisdiction of                  (I.R.S. Employer Identification
incorporation or organization)                    Number)

One Ledgemont Center, 99 Hayden Avenue             02173
Lexington, Massachusetts                          (Zip Code)
(Address of principal executive offices)

Registrant's telephone number, including area code (617) 861-8444

(Former  name,  former  address and former  fiscal year,  if changed  since last
report):Not Applicable

Indicate by check whether the registrant  (1) has filed all reports  required to
be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of 1934 during
the  preceding 12 months (or for such shorter  periods that the  registrant  was
required  to file  such  reports),  and  (2) has  been  subject  to such  filing
requirements for the past 90 days.

         Yes  X      No 
             ---        ---
Indicate  the  number of shares  outstanding  of each of the  issuer's  class of
common stock, as of the latest practicable date.

         Class                                   Outstanding at May 13, 1997:
Common Stock $.001 par value                     41,043,708 shares, excluding
                                                 182,585 treasury shares

                                       -1-





                        INTERNEURON PHARMACEUTICALS, INC.

                               INDEX TO FORM 10-Q


<TABLE>
<CAPTION>

PART I.           FINANCIAL INFORMATION                                                                       PAGE

<S>                                                                                                           <C>             
                  Item 1.           Financial Statements

                  Consolidated Balance Sheets as of March 31, 1997
                  and September 30, 1996......................................................................... 3

                  Consolidated Statements of Operations for the Three and Six Months ended
                  March 31, 1997 and 1996.........................................................................4

                  Consolidated Statements of Cash Flows for the Six Months ended
                  March 31, 1997 and 1996.........................................................................5

                  Notes to Unaudited Consolidated Financial Statements............................................6

                  Item 2.           Management's Discussion and Analysis of Financial
                                    Condition and Results of Operations...........................................9


PART II.          OTHER INFORMATION

                  Item 4.           Submission of Matters to a Vote of
                                    Security Holders.............................................................21

                  Item 6.           Exhibits and Reports on Form 8-K.............................................21


SIGNATURES.......................................................................................................23

</TABLE>

                                       -2-




<TABLE>
<CAPTION>

                                         INTERNEURON PHARMACEUTICALS, INC.
                                            CONSOLIDATED BALANCE SHEETS
                                                    (Unaudited)
                                (Dollar amounts in thousands except per share data)

                                                                                   March 31,         September 30,
                                                                                     1997                 1996
                                                                                     ----                 ----
                                                      ASSETS
Current assets:
<S>                                                                                    <C>                 <C>     
     Cash and cash equivalents                                                         $ 93,414            $145,901
     Marketable securities                                                               29,471              17,068
     Accounts receivable                                                                  1,926               4,338
     Inventories                                                                          6,356               8,376
     Prepaids and other current assets                                                    5,961               1,324
                                                                                    -----------        ------------
             Total current assets                                                       137,128             177,007

Marketable securities                                                                    37,475               6,639
Property and equipment, net                                                               3,024               2,689
Other assets                                                                                165                 103
                                                                                   ------------       -------------
                                                                                       $177,792            $186,438
                                                                                       ========           =========

                                                        LIABILITIES

Current liabilities:
     Accounts payable                                                                 $   2,249           $   2,575
     Accrued expenses                                                                    16,268              11,604
     Deferred revenue                                                                     5,694               6,921
     Current portion of capital lease obligations                                           931                 661
                                                                                     ----------       -------------
             Total current liabilities                                                   25,142              21,761

Long-term portion of capital lease obligations                                            1,194                 526
Other long-term liabilities                                                                  19                  16

Minority interest                                                                        19,016              19,373

                                                   STOCKHOLDERS' EQUITY

Preferred stock, $.001 par value, authorized 5,000,000 shares: Series B, 239,425
     shares  issued and  outstanding  at March 31, 1997 and  September  30, 1996
     (liquidation preference at
     March  31, 1997 $3,041)                                                              3,000               3,000
     Series C, 5,000 shares issued and outstanding at March 31, 1997
     and September 30, 1996  (liquidation preference at
     March  31, 1997  $504)                                                                 500                 500
Common stock, $.001 par value, 80,000,000 shares authorized:
     41,226,293 issued and 41,015,969 shares issued and outstanding at
     March  31, 1997 and September 30, 1996, respectively                                    41                  41
Additional paid-in capital                                                              249,020             247,999
Accumulated deficit                                                                    (117,559)           (106,778)
Unrealized losses on marketable securities                                                 (218)                  -
Treasury stock, at cost, 128,835 shares at March 31, 1997 and no
     shares at September 30, 1996                                                        (2,363)                  -
                                                                                    ------------     --------------
     Total stockholders' equity                                                         132,421             144,762
                                                                                      ---------           ---------
                                                                                       $177,792            $186,438
                                                                                       ========            ========

          The  accompanying  notes  are an  integral  part  of  these  unaudited consolidated financial statements.

</TABLE>

                                       -3-




<TABLE>
<CAPTION>


                                          INTERNEURON PHARMACEUTICALS, INC.
                                                    CONSOLIDATED
                                              STATEMENTS OF OPERATIONS
                             For the three and six months ended March 31, 1997 and 1996
                                                     (Unaudited)
                                     (Amounts in thousands except per share data)


                                    For the three months ended March 31,       For the six months ended March 31,
                                    ------------------------------------       ----------------------------------

                                              1997             1996                        1997            1996
                                              ----             ----                        ----            ----

Revenues:
<S>                                       <C>         <C>                              <C>         <C>         
Product revenue                           $ 17,477    $           -                    $ 31,188    $          -
Contract and license fees                    2,297              905                       6,278           6,249
                                        ----------        ---------                    --------       ---------
   Total revenues                           19,774              905                      37,466           6,249

Costs and expenses:
Cost of product revenue                     11,999                -                      21,903               -
Research and development                     9,966            3,599                      17,484           6,726
Selling, general and administrative          5,827            4,170                      11,344           6,881
Purchase of in-process research
  and development                            2,261            6,084                       2,261           8,234
                                         ---------         --------                   ---------       ---------
     Total costs and expenses               30,053           13,853                      52,992          21,841

Net loss from operations                   (10,279)         (12,948)                    (15,526)        (15,592)

Investment income, net                       2,008              555                       4,597             989

Minority interest                              421              432                         148            (542)
                                         ---------        ---------                  ----------       ----------

Net loss                                   $(7,850)        $(11,961)                   $(10,781)       $(15,145)
                                           ========        =========                   =========       =========

Net loss per common share                 $ ( 0.19)       $  ( 0.34)                 $   ( 0.26)     $    (0.44)
                                          =========       ==========                 ===========     ===========

Weighted average common
      shares outstanding                    41,098           35,308                      41,059          34,411
                                           =======         ========                     =======        ========




          The  accompanying  notes  are an  integral  part  of  these  unaudited consolidated financial statements.

</TABLE>


                                       -4-



<TABLE>
<CAPTION>
                                          INTERNEURON PHARMACEUTICALS, INC.
                                                    CONSOLIDATED
                                              STATEMENTS OF CASH FLOWS
                                   For the six months ended March 31, 1997 and 1996
                                                     (Unaudited)
                                            (Dollar amounts in thousands)

                                                                    Six months ended March 31,
                                                                    --------------------------
                                                                    1997                  1996
                                                                    ----                  ----

Cash flows from operating activities:
<S>                                                            <C>                 <C>         
     Net loss                                                  $   (10,781)        $   (15,145)
     Adjustments to reconcile net loss to net cash
     used by operating activities:
         Depreciation and amortization                                 646                 381
         Gain on disposal of fixed assets                                -                  (6)
         Minority interest in net income/loss of
            consolidated subsidiaries                                 (148)                542
         Purchase of in-process research and development             1,861               8,098
         Noncash compensation                                          176                 896
         Change in assets and liabilities:
             Accounts receivable                                     2,412                (908)
             Inventories                                             2,020              (3,629)
             Prepaids and other current assets                      (4,637)               (281)
             Other assets                                              (62)                 97
             Accounts payable                                         (326)                937
             Deferred revenue                                       (1,227)              1,942
             Accrued expenses and other liabilities                  4,452                (559)
                                                           ---------------     ----------------
Net cash (used) by operating activities                             (5,614)             (7,635)
                                                             --------------      --------------

Cash flows from investing activities:
     Capital expenditures                                             (726)               (141)
     Purchase of marketable securities                             (53,600)            (36,233)
     Proceeds from maturities and sales of
        marketable securities                                       10,143              21,789
     Purchases of Intercardia stock                                 (2,436)                  -
     Proceeds from disposal of fixed assets                              -                  40
                                                          -----------------     ---------------
Net cash (used) by investing activities                            (46,619)            (14,545)
                                                              -------------    ----------------

Cash flows from financing activities:
     Net proceeds from issuance of common and treasury stock         1,101              13,608
     Net proceeds from issuance of stock by subsidiaries               276              30,362
     Purchase of treasury stock                                     (2,315)                  -
     Proceeds from sale/leaseback                                    1,050                 132
     Principal payments of capital lease obligations                  (366)               (244)
                                                            ---------------    ----------------
Net cash (used) provided by financing activities                      (254)             43,858
                                                            ---------------     ---------------

Net change in cash and cash equivalents                            (52,487)             21,678
Cash and cash equivalents at beginning of period                   145,901              16,781
                                                             -------------      --------------

Cash and cash equivalents at end of period                     $    93,414       $      38,459
                                                               ===========       -------------
</TABLE>




         The accompanying notes are an integral part of these unaudited
                       consolidated financial statements.

                                       -5-





                        INTERNEURON PHARMACEUTICALS, INC.

              NOTES TO UNAUDITED CONSOLIDATED FINANCIAL STATEMENTS

A.    Basis of Presentation:

      The consolidated  financial  statements included herein have been prepared
by Interneuron  Pharmaceuticals,  Inc. without audit,  pursuant to the rules and
regulations of the Securities and Exchange  Commission.  Certain information and
footnote  disclosures  normally  included in  financial  statements  prepared in
accordance with generally accepted accounting  principles have been condensed or
omitted  pursuant to such rules and  regulations.  In the opinion of management,
the  accompanying   unaudited  consolidated  financial  statements  include  all
adjustments  (consisting  only of normal  recurring  adjustments)  necessary  to
present fairly the consolidated  financial  position,  results of operations and
cash flows of the  Company.  The  unaudited  consolidated  financial  statements
included  herein  should be read in  conjunction  with the audited  consolidated
financial  statements and the notes thereto  included in the Company's Form 10-K
for the fiscal year ended September 30, 1996.

     The unaudited  consolidated  financial  statements  include the accounts of
Interneuron  Pharmaceuticals,  Inc.  ("Interneuron"  or the  "Company")  and its
subsidiaries (the "Subsidiaries"),  Progenitor,  Inc. ("Progenitor"),  Transcell
Technologies,  Inc.  ("Transcell"),   Intercardia,  Inc.  ("Intercardia"),   and
InterNutria,  Inc.  ("InterNutria").  All significant  intercompany activity has
been eliminated.

     The Company will adopt Statement of Financial Accounting Standards No. 128,
Earnings Per Share ("SFAS 128") in the quarter  ending  December 31, 1997.  SFAS
128  requires  the  Company to change its method of  computing,  presenting  and
disclosing earnings per share information.  Upon adoption, all prior period data
presented will be restated to conform to the provisions of SFAS 128.
Management has not determined the effect of adopting SFAS 128.

B.   Significant Accounting Policies:

     Certain  prior year amounts have been  reclassified  to conform with fiscal
1997 classifications.

C.  Inventories:

<TABLE>
<CAPTION>

     Inventories consisted of:                                 March 31,         September 30,
                                                                1997                 1996
                                                            ------------          ----------

<S>                                                           <C>                 <C>       
     Raw materials                                            $4,168,000          $5,420,000
     Finished goods                                            2,188,000           2,956,000
                                                            ------------          ----------
                                                              $6,356,000          $8,376,000
                                                              ==========          ==========
</TABLE>

     Raw materials  consisted  primarily of  dexfenfluramine  drug substance and
finished goods consisted primarily of finished and packaged Redux(TM) capsules.


                                       -6-





D.  Subsidiaries:

     In December 1996,  Progenitor  entered into an agreement  with Amgen,  Inc.
("Amgen") (the "Amgen  Agreement"),  granting Amgen certain exclusive rights for
the  development and  commercialization  of products using  Progenitor's  leptin
receptor  technology.  Amgen paid  Progenitor a $500,000  initial license fee in
January 1997, which was reflected in contract and license fee revenue in the six
month  period  ended March 31,  1997.  Progenitor  may also  receive  from Amgen
certain development and regulatory milestone payments and potential royalties on
sales.  Amgen also agreed to purchase  Progenitor common stock in the event of a
Progenitor initial public offering.

     In December 1996,  Intercardia executed an agreement with BASF Pharma/Knoll
AG  ("Knoll")  ("the  Knoll  Collaboration")  to  provide  for the  development,
manufacture  and marketing of bucindolol in all countries  with the exception of
the United States and Japan (the "Territory").  The Knoll Collaboration  relates
to both the twice-daily  bucindolol  formulation  and the once-daily  bucindolol
formulation   currently  under  development.   Under  the  terms  of  the  Knoll
Collaboration,  Knoll made in December 1996 a $2,143,000  payment to CPEC,  Inc.
("CPEC",  Intercardia's majority-owned subsidiary, of which Interneuron owns the
minority  portion)  which was  recognized as contract and license fee revenue in
the six month period ended March 31, 1997,  and a $1,000,000  payment to CPEC in
January  1997 which was  recognized  as contract  and license fee revenue in the
three  and six month  periods  ended  March 31,  1997.  Knoll  will make  future
payments to CPEC upon the achievement of product approval and sales milestones.

     Knoll and  Intercardia  will share the  development  and marketing costs of
bucindolol in the Territory.  In general,  Knoll shall pay  approximately 60% of
the  development  and marketing  costs prior to product  launch and  Intercardia
shall pay  approximately  40% of such costs,  subject to certain  maximum dollar
limitations.  CPEC will be entitled to a royalty equal to 40% of net profits, as
defined in the Knoll  Collaboration,  and would be  responsible  for, and pay to
Knoll, 40% of any net loss, as defined.

     In February 1997,  Progenitor  announced an agreement to acquire  Mercator,
Inc.  ("Mercator")  a  privately-held  genomics  company,   subject  to  certain
conditions, including completion of an initial public offering by Progenitor for
approximately  $22,000,000,   payable  in  Progenitor  common  stock,  plus  the
assumption of Mercator  liabilities.  Progenitor also agreed to provide Mercator
with an interim  operating line of credit through July 1997 of up to $6,600,000,
funding for which will be provided by Interneuron.  At March 31, 1997,  advances
under this line of credit totaled approximately  $1,300,000 and are reflected in
prepaids and other current assets.

     In March 1997, Progenitor filed registration statements with the Securities
and  Exchange  Commission  relating  to a proposed  initial  public  offering of
2,750,000  shares of Progenitor  common stock (plus up to an additional  412,500
shares to cover  over-allotments)  and the proposed acquisition by Progenitor of
Mercator.  Based on the  proposed  terms of the  offering  and the  acquisition,
assuming the  completion  of the offering  and the Mercator  acquisition  on the
filed terms,  Interneuron will own approximately 43% of Progenitor's outstanding
common stock without giving effect to any exercise of the over-allotment  option
or any options or  warrants,  and subject to change based upon the timing of the
offering, the offering price, the number of Progenitor shares


                                       -7-





issued  in  connection   with  the  Mercator   acquisition  and  the  amount  of
Progenitor's  indebtedness to Interneuron.  In connection with the  acquisition,
Progenitor will incur non-recurring charges to operations currently estimated to
aggregate  approximately  $30,000,000,  a portion of which are non-cash  charges
related to the  purchase  of  in-process  research  and  development  subject to
increase based upon several factors including the timing of the transactions and
unanticipated  costs.  Due to market  conditions and other factors,  there is no
assurance that  Progenitor's  initial public offering or acquisition of Mercator
will be completed, in which case Progenitor will incur charges to operations for
amounts  expended in connection  with the two proposed  transactions,  including
funds  advanced under the line of credit.  Interneuron  will record a portion of
these charges based on its ownership interest in Progenitor.

E.   Other:

     In February  1997,  the Company  announced  that its Board of Directors had
authorized it to purchase from time to time through open-market  transactions up
to 200,000 shares of the common stock of Intercardia.  As of March 31, 1997, the
Company  had  purchased  104,400  shares  of  Intercardia  common  stock  for an
aggregate  purchase price of approximately  $2,436,000,  of which  approximately
$1,861,000  was recorded as purchase of in-process  research and  development in
the three and six  month  periods  ended  March 31,  1997.  As a result of these
purchases,  the  Company's  ownership  of  Intercardia  increased  from 59.6% at
September  30,  1996 to  61.0% at March  31,  1997  based  upon  the  number  of
outstanding shares of Intercardia at such dates.

     At the Company's  annual  meeting of  stockholders,  on March 5, 1997,  the
Company's  stockholders  approved an increase to the number of authorized shares
of Common Stock from 60,000,000 to 80,000,000.

     In March  1997,  the  Company  announced  that its Board of  Directors  had
authorized it to repurchase from time to time through  open-market  transactions
up to 1,500,000  shares of the Company's Common Stock. As of March 31, 1997, the
Company  had  repurchased  142,500  shares for an  aggregate  purchase  price of
approximately  $2,619,000,  of which  13,665  shares were  reissued  pursuant to
employee  stock  option  and stock  purchase  plans.  Such  repurchases  and re-
issuances are recorded as treasury stock transactions.

     At March 31, 1997,  the Company had  outstanding a Standby Letter of Credit
for $800,000 to secure  certain  facility and laboratory  build-out  costs being
incurred by a subsidiary as part of a lease for its  headquarters.  This Standby
Letter of Credit is  collateralized  by a certificate of deposit and expires the
sooner of September 15, 1997 or receipt by the subsidiary's  landlord of payment
of the build-out costs.

F.   Subsequent Event:

     On May 9, 1997, the Company  purchased in private  transactions  from Swiss
Bank  Corporation,  London  Branch  ("SBC")  capped call options on  Interneuron
Common Stock. These call options give Interneuron the right to purchase from SBC
up to a total of 1,240,000 shares of Interneuron  Common Stock at a strike price
of $17.75. The call options are exercisable only at their maturities,  which are
September  24, 1997,  March 9, 1998,  May 21, 1998 and August 24, 1998 each with
respect to 310,000 shares, and are subject to caps of $26.00, $34.00, $38.00 and
$40.00,  respectively,  which limit the economic benefit to the Company of these
call options.  The call options  which the Company  purchased are expected to be
settled,  if exercised,  with cash in an amount equal to the difference  between
the  strike  price and the  market  price,  subject to caps which will limit the
total amount of cash the Company  could receive or increase the strike prices in
the case of stock settlement when the market price of the Company's Common Stock
exceeds the applicable cap price.




                                       -8-






     In  exchange  for the  purchases  of these  call  options,  in lieu of cash
purchase prices,  the Company sold to SBC call options entitling SBC to purchase
from the  Company  at a strike  price of  $40.30  per  share,  an  aggregate  of
2,000,000 shares of Interneuron Common Stock, 1,000,000 shares on each of May 21
and May 24,  1999.  The Company will have the right to settle these call options
with cash or stock,  subject to certain  conditions.  If exercised,  the Company
expects to settle the call options that it sold through issuances by the Company
to SBC of up to an  aggregate  of 2,000,000  authorized  and unissued  shares of
Common Stock, subject to the effectiveness of a registration  statement covering
the resale of these shares. The sale or potential sale of such shares could have
an adverse effect on the market price of the Company's Common Stock.

     SBC has  advised  that it has  engaged,  and may engage,  in  transactions,
including buying and selling shares of the Company's Common Stock, to offset its
risk relating to the options.  Purchases and sales could affect the market price
of the Company's Common Stock.

Item 2. Management's Discussion and Analysis of Financial Condition and Results
        of Operations:

     Statements in this Form 10-Q that are not  descriptions of historical facts
are  forward-looking  statements  that are  subject to risks and  uncertainties.
Actual results could differ materially from those currently anticipated due to a
number of factors,  including those set forth in the Company's filings under the
Securities  Act of 1933 and  under the  Securities  Exchange  Act of 1934  "Risk
Factors"  and  elsewhere,   including,  in  particular  risks  relating  to  the
commercialization of Redux, such as marketing and revenue fluctuations,  safety,
regulatory,  competition  patent,  product  liability,  supply and other  risks;
uncertainties  relating to clinical trials;  manufacturing and supply risks; the
early  stage  of  products  under  development;  risks  related  to  contractual
obligations;  risks relating to product launches and managing growth; government
regulation, patent risks, dependence on third parties and competition.

     The following  discussion  should be read in conjunction with the Company's
unaudited   consolidated   financial  statements  and  notes  thereto  appearing
elsewhere in this report and audited consolidated financial statements and notes
thereto included in the Company's Annual Report on Form 10-K for the fiscal year
ended September 30, 1996. Unless the context indicates otherwise, all references
to the Company include Interneuron and its Subsidiaries.

Redux

     On April 29,  1996,  the  Company's  first  pharmaceutical  product,  Redux
(dexfenfluramine  hydrochloride  capsules)  C-IV received  clearance by the U.S.
Food and Drug Administration ("FDA") for marketing as a twice-daily prescription
therapy to treat  obesity.  The approved  indication  is for the  management  of
obesity,  including  weight loss and maintenance of weight loss in patients on a
reduced calorie diet who have a body mass index ("BMI") of greater than or equal
to 30 kg/m2 or greater  than or equal to 27 kg/m2 in the  presence of other risk
factors, such as hypertension,  diabetes and elevated cholesterol. Under license
and co-promotion agreements, Redux is being marketed in the U.S. by Wyeth-Ayerst
Laboratories ("Wyeth-Ayerst"), a division

                                       -9-





of American Home Products Corp. ("AHP")  and co-promoted by the Company.

     The Company's  revenues  relating to Redux are currently  primarily derived
from:  (1) royalties  paid by AHP to the Company based on the net sales of Redux
capsules by AHP to  distributors;  (2) sales of Redux  capsules to AHP;  and (3)
financial support of the Company's sales force provided by AHP.

     The  Company's  license  agreement  with AHP provides for  royalties to the
Company  consisting of (i) "base"  royalties  equal to 11.5% of AHP's net sales,
(an amount  equal to the total  royalties  required to be paid by the Company to
Les Laboratoires Servier ("Servier"),  and (ii) "additional"  royalties based on
net sales of Redux by AHP.  The  percentage  of  "additional"  royalties  varies
depending  upon (x) the status of Redux as a scheduled or  descheduled  drug and
(y) whether or not the Company  supplies the finished  capsules of Redux to AHP.
At March 31, 1997, Redux was scheduled as a controlled substance and the Company
manufactures  the finished  dosage  formulation  of the drug. In April 1997, the
Drug Enforcement  Agency ("DEA")  published a recommendation  for the removal of
fenfluramine and its isomers including  dexfenfluramine from Schedule IV and all
other controls of the Controlled  Substances  Act. If after a comment period the
DEA were to issue a final rule consistent with its proposal, then Redux would no
longer  carry the C-IV  designation  and would no longer be  subject to such DEA
controls.  Certain states will  deschedule the drug  automatically  upon federal
descheduling while other states have varying proceedures for descheduling.

     The following sets forth the applicable  "additional"  royalties payable to
the Company based on annual net sales, on an annual contract basis commencing in
May of each contract year,  assuming the Company is supplying  finished capsules
of Redux,  based on the status of  dexfenfluramine as a scheduled or descheduled
drug:

         Scheduled
         ---------
         First $50,000,000                                        5.0%
         Next $100,000,000                                        8.0%
         Over $150,000,000                                       10.0%

         Descheduled
         -----------
         First $150,000,000                                       8.0%
         Next $ 50,000,000                                       10.0%
         Over $200,000,000                                       11.0%

     Royalty  rates are subject to a 50%  reduction if generic drug  competition
exceeds a 10% market share in two consecutive  quarters.  The Company recognizes
royalty revenue and associated expense in the fiscal quarter when AHP reports to
Interneuron  AHP's  shipments  to  distributors. Accordingly, royalty revenue is
reported  by the  Company in the  quarter  following  actual  shipments  by AHP.
Pursuant to the Company's  agreement with AHP, if the potential  descheduling of
Redux were to occur within a year of FDA approval, AHP would be required to make
a milestone payment to, and equity investment in, the Company. Due to the timing
of the potential descheduling, the

                                      -10-





Company believes it may not receive the  descheduling-related  milestone payment
and equity investment from AHP.

     Under a copromotion agreement with Wyeth-Ayerst effective June 1, 1996, the
Company's sales force is promoting Redux to selected specialists,  in return for
financial support of the sales force and a percentage of resulting revenues less
certain  expenses.  The copromotion  agreement with AHP calls for a reduction of
the Redux  sales  force  costs paid by AHP to  Interneuron  from 100% during the
first year of the  agreement  to 50% during  the second  year of the  agreement.
Total maximum payments from AHP will be reduced to approximately  $1,650,000 for
the twelve month period  beginning June 1997 from  approximately  $3,300,000 for
the twelve month period which commenced in June 1996. The copromotion  agreement
is cancelable by Wyeth-Ayerst  under certain  conditions.  There is no assurance
the  Company  will  meet  such  conditions  which  includes  a  minimum  revenue
requirement for which sufficient information is currently not available.

     The  Company  has  a  manufacturing  agreement  with  Boehringer  Ingelheim
Pharmaceuticals,  Inc.  ("Boehringer")  under which Boehringer  manufactures and
packages  finished  capsules  of Redux on behalf of the Company for sale to AHP.
This  agreement  obligates  Boehringer to provide,  and the Company to purchase,
manufactured Redux capsules to the extent defined in the agreement,  through the
current  contract  expiration  date of December 31, 1998.  At the  expiration or
termination  of the  agreement,  the Company would be obligated to purchase from
Boehringer  any unused  manufacturing  materials,  work in process,  or finished
product and to assume any unfilled  Boehringer  purchase  commitments that could
not be canceled prior to the expiration or termination of the agreement.  If the
Boehringer  agreement is not extended,  the Company will be required to obtain a
replacement  good  manufacturing   practices  ("GMP")  qualified   manufacturing
facility  for  Redux.   The  Company  is  currently   evaluating   manufacturing
alternatives.  There can be no  assurance  a  replacement  manufacturer  will be
approved  by the  FDA  in  sufficient  time  to  avoid  an  interruption  in the
commercial  supply of Redux.  The Company  recognizes  revenue  from the sale of
these capsules upon acceptance by AHP, typically 45 days after shipment.

     Included in the  FDA-approved  labeling for Redux are references to certain
risks that may be associated  with  dexfenfluramine  and which were  highlighted
during the FDA's review of the drug.  One issue  relates to whether  there is an
association between appetite suppressants,  including  dexfenfluramine,  and the
development of primary pulmonary  hypertension  ("PPH"), a rare but serious lung
disorder  estimated to occur in the general  population  at one to two cases per
million  adults per year. An  epidemiologic  study  conducted in Europe known as
IPPHS (International Primary Pulmonary Hypertension Study) examined risk factors
for PPH and showed that among other factors,  weight reduction drugs,  including
dexfenfluramine,  and obesity itself were  associated with a higher risk of PPH.
In the final report of IPPHS,  published in the New England  Journal of Medicine
(August 29, 1996), the authors  estimated yearly  occurrence of PPH for patients
taking  appetite  suppressants  for  greater  than three  months  duration to be
between 23 and 46 cases per million  patients per year. The revised labeling for
Redux discloses this revised estimate.

     The FDA-approved  labeling for Redux also includes discussion as to whether
dexfenfluramine is associated with certain  neurochemical  changes in the brain.
Certain studies conducted by third parties related to this issue purport to show
that very high doses of dexfenfluramine  cause prolonged  serotonin depletion in
certain   animals,   which  some   researchers   believe  is  an  indication  of
neurotoxicity.   The  Company  has  presented  data  relating  to  the  lack  of
neurocognitive effects in patients taking Redux to the FDA and believes that, as
demonstrated in human trials, these animal



                                      -11-





studies  are  clinically   irrelevant  to  humans  because  of   pharmacokinetic
differences  between  animals and humans and because of the high dosages used in
the animal  studies.  The Company and Wyeth-  Ayerst have agreed with the FDA to
conduct a certain  Phase 4, or  post-marketing,  study of Redux.  This study and
related costs are estimated to be approximately  $10,000,000 and are expected to
be incurred  primarily by Interneuron  over an  approximately  two to three year
period. Wyeth-Ayerst is responsible to pay for 50% of these estimated costs.

     The use  patent  on  dexfenfluramine  currently  expires  in mid  2000.  In
accordance  with the  Waxman-Hatch Act, the U.S.  Patent  and  Trademark  Office
("PTO") is currently  considering an extension of the dexfenfluramine  patent to
compensate  the  Company  for a portion  of the time  dexfenfluramine  was being
tested and  considered for approval.  The PTO has instituted a petition  period,
which ends on August 27, 1997,  during which it will accept  comments  regarding
such  extension.  If such  extension is granted by the PTO, the  dexfenfluramine
patent will be extended for  approximately  an additional  3.5 years.  Also, the
Company  believes it is entitled under the  Waxman-Hatch  Act to a minimum three
year  period  of  exclusivity  from  the  date  of FDA  approval,  during  which
applications for generic versions of the drug may not be approved,  although the
Company  has  applied  for a five year  period of  exclusivity.  There can be no
assurance  of  receipt  of such  exclusivity  or patent  extension  on  a timely
basis or at all.

     Redux may be subject to substantial competition. AHP also sells Pondimin to
treat  obesity.  In May 1997,  an FDA  advisory  panel  recommended  approval of
Xenical,  a Hoffman-La  Roche,  Inc.  drug,  for the  treatment  of obesity.  In
addition,  other drugs, including sibutramine,  for which an NDA has been filed,
and technologies are under regulatory review or development to treat obesity.

     Inventories  of  $6,356,000  at  March  31,  1997  consisted  primarily  of
dexfenfluramine  drug  substance  and finished  and packaged  capsules of Redux.
Inventories  decreased from $8,376,000 at September 30, 1996.  Inventory  levels
depend to a large extent on sales forecasts provided by AHP, AHP's management of
its  inventory  levels,  production  planning  by the  Company,  and  production
capabilities  of Boehringer.  There can be no assurance that  Boehringer will be
able to manufacture product in adequate quantities or on a timely basis, or that
AHP's sales  forecasts and the Company's  production  planning will be accurate,
which may  result in higher  inventory  costs to the  Company or  inadequate  or
excessive supplies of the product.  In addition,  there can be no assurance that
the  manufacture of the capsules and their sale to AHP will result in profits to
Interneuron.  Because of the relativity  limited (less than one year)  marketing
experience  with Redux,  the Company is unable to predict with certainty  trends
for Redux sales or AHP and Interneuron inventory balances. Further, there may be
fluctuations in Redux sales which could

                                      -12-





affect inventory  balances as a result of many factors,  including  seasonality,
promotion and advertising,  publicity, the introduction of competitive products,
and other factors.  AHP pays the Company for certain portions of dexfenfluramine
drug substance prior to its incorporation into the manufacturing  process.  Such
payments  are  included  in, and are the  majority  components  of, the deferred
revenue balance of $5,694,000 at March 31, 1997.

Results of Operations

     Total revenues  increased  substantially in the three and six month periods
ended March 31, 1997 over the same periods in the prior fiscal year primarily as
a result of the launch of Redux in June 1996.  Total  revenues of $19,774,000 in
the three month period ended March 31, 1997  consisted of $17,477,000 of product
revenue and  $2,297,000  of contract  and license  fees,  and total  revenues of
$37,466,000  in  the  six  month  period  ended  March  31,  1997  consisted  of
$31,188,000 of product revenue and $6,278,000 of contract and license fees.

     Product  revenue of  $17,477,000  in the three month period ended March 31,
1997 consists primarily of royalty revenue of approximately $10,200,000 based on
AHP's  net sales of Redux  and  approximately  $7,100,000  of  revenue  from the
Company's sale of Redux capsules to AHP.  Product  revenue of $31,188,000 in the
six month period ended March 31, 1997 consists  primarily of royalty  revenue of
approximately  $17,000,000  based on AHP's net sales of Redux and  approximately
$13,900,000  of revenue from the  Company's  sale of Redux  capsules to AHP. The
Company  recognizes  Redux  royalty  revenue  when net sales are reported to the
Company by AHP,  which  occurs in the quarter  after AHP  shipments  of Redux to
distributors.  The Company did not report any product  revenue in the comparable
fiscal 1996 periods.

     Contract  and license  fee  revenue  increased  $1,392,000,  or 154%,  from
$905,000 for the three month period ended March 31, 1996 to  $2,297,000  for the
three month  period  ended March 31, 1997 and was  $6,278,000  for the six month
period ended March 31, 1997,  essentially  unchanged from $6,249,000 for the six
month period  ended March 31, 1996.  The increase in the 1997 three month period
reflects  primarily CPEC's contract payment from Knoll and the Company's revenue
from  Wyeth-Ayerst  supporting the Interneuron Redux sales force pursuant to the
Copromotion Agreement with Wyeth-Ayerst. Contract and license fee revenue in the
six month period ended March 31, 1996  consisted  primarily of  $5,000,000  CPEC
received  pursuant  to its  agreement  with Astra Merck for the  development  of
bucindolol and in the six month period ended March 31, 1997 consisted  primarily
of  CPEC's  contract   payments  from  Knoll  and  the  Company's  revenue  from
Wyeth-Ayerst  supporting  the  Interneuron  Redux  sales  force  pursuant to the
Copromotion Agreement with Wyeth-Ayerst.

     Total costs and expenses increased  $16,200,000,  or 117%, from $13,853,000
for the three month  period  ended March  31,1996 to  $30,053,000  for the three
month period ended March 31, 1997 and $31,151,000, or 143%, from $21,841,000 for
the six month  period  ended  March 31,  1996 to  $52,992,000  for the six month
period ended March 31, 1997. Cost of product revenue, which did not exist in the
fiscal 1996 periods,  comprised approximately 74% and 70%, respectively,  of the
three and six month period increases in total costs and expenses.  The three and
six month  periods  ended March 31, 1997  included  expense for the  purchase of
in-process  research and development of $2,261,000  resulting primarily from the
Company's open market purchases of Intercardia common stock (see Note E of Notes
to Unaudited Consolidated Financial Statements). The three

                                      -13-





and six month periods ended March 31, 1996 included  expense for the purchase of
in-process research and development of $6,084,000 from the Company's acquisition
of the remaining 20% of CPEC which was not owned by  Intercardia in exchange for
the issuance of Interneuron  Common Stock,  and the six month period ended March
31,  1996  included  expense of  $2,150,000  for  InterNutria's  acquisition  of
technology  and  know-how  related  to PMS  Escape  which is  being  paid by the
issuance of Interneuron Common Stock.

     Research and  development  expenses  increased  $6,367,000,  or 177%,  from
$3,599,000  for the three month period ended March 31,1996 to $9,966,000 for the
three  month  period  ended  March  31,  1997 and  $10,758,000,  or  160%,  from
$6,726,000 for the six month period ended March 31, 1996 to $17,484,000  for the
six month period ended March 31, 1997. Increases in the 1997 three and six month
periods reflect expenses relating to two pivotal Phase 3 citicoline  trials, the
pivotal Phase 2/3  pagoclone  clinical  trial  initiated in the first quarter of
fiscal  1997,   Intercardia's   expenses   relating  to  once-a-day  and  tablet
formulations of bucindolol,  certain post-approval clinical expenses relating to
Redux and  additional  staffing  and  related  expenses  at the  Company and the
Subsidiaries.  Research and development expenses include only a relatively small
amount for bucindolol,  as a substantial portion of the non-government sponsored
development  expenses for bucindolol  have been assumed,  and are being paid, by
Astra Merck.

     Selling, general and administrative expenses increased $1,657,000,  or 40%,
from $4,170,000 for the three month period ended March 31,1996 to $5,827,000 for
the three  month  period  ended  March 31,  1997 and  $4,463,000,  or 65%,  from
$6,881,000 for the six month period ended March 31, 1996 to $11,344,000  for the
six month period ended March 31, 1997.  These  increases  are  primarily  due to
costs relating to the Company's Redux sales force,  increased  personnel  costs,
additional staffing,  consultants and insurance relating to the Company's growth
and promotional  expenses  incurred for regional test launches of PMS Escape(TM)
and  Melzone(TM).  Partially  offsetting  these  increases  was a  non-recurring
expense  recorded in the three month period  ended March 31, 1996 for  severance
and  related  charges  incurred  by  Transcell  relating  to certain  management
changes.

     Investment  income, net of interest expense,  increased  substantially over
the three and six month  periods  herein  reported due to  significantly  higher
invested balances of cash, cash equivalents and marketable  securities resulting
primarily  from  funds  received  from  public   offerings  in  fiscal  1996  by
Interneuron and Intercardia.

     The  Company  from time to time  explores  various  technology,  product or
company acquisitions and/or financing  opportunities and is currently engaged in
discussions relating to such opportunities. Any such initiatives may involve the
issuance of shares of Interneuron's Common Stock and/or financial commitments to
fund product  development,  either of which may  adversely  affect the Company's
consolidated financial condition or results of operations.

Liquidity and Capital Resources

     Cash, Cash Equivalents and Marketable Securities:

     At March 31, 1997, the Company had cash,  cash  equivalents  and marketable
securities aggregating  $160,360,000,  compared to $169,608,000 at September 30,
1996.  Approximately  $4,600,000 of this decrease is the result of the Company's
open-market purchases of Intercardia

                                      -14-





and  Interneuron  Common  Stock (see Note E of Notes to  Unaudited  Consolidated
Financial Statements).




     Clinical Studies:

     The Company is incurring  substantial  expenditures for product development
and clinical  trials.  In  particular,  the Company is performing two additional
pivotal  Phase 3 clinical  trials of  citicoline  (along  with other  supportive
trials),  for  treatment  of  ischemic  stroke,  one of which is  expected to be
completed  during the third  quarter of fiscal  1997 (the  "Fiscal  1997 Phase 3
Trial") and one of which is  expected  to extend  into fiscal 1998 (the  "Fiscal
1998 Phase 3 Trial"). There can be no assurance the Fiscal 1997 Phase 3 Trial or
the Fiscal 1998 Phase 3 Trial will confirm the results of the initial  completed
pivotal Phase 3 trial on  citicoline.  Depending  upon the results of the Fiscal
1997 Phase 3 Trial the Company may file an NDA for  citicoline to treat ischemic
stroke within  approximately  six months after completion of the analysis of the
data.  The Fiscal  1998 Phase 3 Trial may be used to  support  product  labeling
requirements.  Assuming the Company files an NDA after  completion of the Fiscal
1997 Phase 3 Trial, the costs of all currently known clinical trials and related
studies and the  preparation of the NDA are estimated,  based upon current trial
protocols,  to  aggregate  approximately  $17,500,000,  of  which  approximately
$4,400,000  has been paid  through  March 31,  1997.  The  Company  is unable to
predict with certainty the costs of any related or additional  clinical  studies
which  will  depend  upon  the  results  of the  ongoing  trials  and  upon  FDA
requirements. If the Company does not file an NDA after completion of the Fiscal
1997 Phase 3 Trial,  it may conduct  additional  trials which would increase the
total estimated costs relating to the development of citicoline.

     The Company is currently  evaluating the marketing strategy for citicoline.
The Company is  considering  sole marketing of the product to  office-based  and
hospital-based physicians but has also commenced negotiations with certain major
pharmaceutical  companies  regarding the  co-promotion  of the product to market
segments  requiring  extensive  sales force  coverage.  In the event the Company
markets citicoline directly,  significant additional funds would be required for
manufacturing,  distribution,  marketing  and  selling  efforts.  The Company is
dependent  upon  third  party  suppliers  of  citicoline  for  manufacturing  in
accordance  with the Company's and  applicable  regulatory  requirements  and is
subject to an  agreement  requiring  the  Company  to  purchase  citicoline  for
commercial purposes at fixed prices, subject to certain conditions. There can be
no assurance the Company will establish or maintain  marketing or  manufacturing
capabilities required to successfully commercialize citicoline.

     The Company is also incurring  substantial  costs to develop  pagoclone for
which a Phase 2/3 trial  commenced in November  1996.  The Company  designates a
trial as Phase 2/3 if it is a well-controlled trial which the Company may choose
to utilize,  depending upon results,  as a pivotal or supporting trial in an NDA
submission.  The  Company  has  estimated  the total  costs of certain  clinical
studies,  license fees to  Rhone-Poulenc  Rorer  Pharmaceuticals,  Inc., and NDA
preparation  for  pagoclone  to be  approximately  $33,000,000,  which  will  be
incurred  over the next  several  years.  The Company is unable to predict  with
certainty the costs of any related or  additional  studies which may be required
by the FDA.  Further,  in the  event the  Company  markets  pagoclone  directly,
significant  additional funds would be required for manufacturing,  distribution
and selling efforts.

                                      -15-





     In  December  1996,  the  Company  entered  into an  agreement  with  Algos
Pharmaceutical    Corporation   to   collaborate   in   the    development   and
commercialization of LidodexNS(TM),  which combines two drugs that are currently
marketed for other  indications.  This  combination  product is in  pre-clinical
development  for the acute  intra-nasal  treatment  of migraine  headaches.  The
development of this and other products, including those which may be acquired by
the Company in the future will require substantial additional funds.

     There can be no assurance  that results of ongoing  current  preclinical or
clinical trials will be successful, that additional trials will not be required,
that any drug under  development will receive FDA approval in a timely manner or
at all, or that such drug could be successfully  manufactured in accordance with
good  manufacturing  practice  regulations or marketed in a timely manner, or at
all, any of which could materially adversely affect the Company.

     Analysis of Cash Flows:

     Cash used by  operating  activities  during the six months  ended March 31,
1997 of $5,614,000  consisted primarily of a net loss of $10,781,000 and changes
in assets and liabilities as follows:

     (i) a decrease in accounts  receivable  of  $2,412,000  from  $4,338,000 at
September  30, 1996 to  $1,926,000 at March 31, 1997  primarily  resulting  from
collections from AHP and reduced billings to AHP .

     (ii) a decrease in inventories of $2,020,000  from  $8,376,000 at September
30, 1996 to $6,356,000  at March 31, 1997,  reflecting a reduction in production
of Redux capsules and their sale to AHP.

     (iii) an increase of $4,637,000  in prepaid and other  current  assets from
$1,324,000 at September  30, 1996 to $5,961,000 at March 31, 1997  primarily due
to Progenitor's  approximately  $1,700,000 of prepaid and accrued costs relating
to  its  proposed   initial  public   offering  and  Mercator   acquisition  and
approximately  $1,300,000  advanced by  Progenitor  to Mercator  under a line of
credit arrangement.

     (iv) an increase of  $4,452,000 in accrued  expenses and other  liabilities
primarily  due to  increased  accruals  relating  to  research  and  development
contracts,   Progenitor's  accrual  of  initial  public  offering  and  Mercator
acquisition  costs,  and accrued Redux  inventory  purchases.  Accrued  expenses
consist  primarily  of  obligations  related to  clinical  trials and  sponsored
research, consultants and other service providers, compensation and other items.

     Cash used by  investing  activities  during the six months  ended March 31,
1997 of $46,619,000  consisted  primarily of purchases of marketable  securities
(investments purchased with maturities greater than three months) of $53,600,000
resulting  mainly from funds available from maturities of securities  classified
as cash equivalents and the Company's $2,436,000 purchase of Intercardia stock.

     Cash used by  financing  activities  during the six months  ended March 31,
1997 of $254,000  consisted of $2,315,000 used to purchase  treasury stock which
was partially offset by inflows of $1,101,000 from issuances common and treasury
stock and $1,050,000 from proceeds from sales

                                      -16-




and leasebacks of fixed assets.

     Other:

     In February  1997,  Interneuron  announced  that its Board of Directors had
authorized it to purchase  from time to time up to 200,000  shares of the common
stock of  Intercardia.  As of March 31, 1997, the Company had purchased  104,400
shares  of  Intercardia   common  stock  for  an  aggregate  purchase  price  of
approximately  $2,436,000,  of which  approximately  $1,861,000  was recorded as
purchase  of  in-process  research  and  development  in the three and six month
periods  ended March 31, 1997.  As a result of these  purchases,  the  Company's
ownership of Intercardia  increased from 59.6% at September 30, 1996 to 61.0% at
March 31, 1997 based upon the number of  outstanding  shares of  Intercardia  at
such dates.

     In March  1997,  the  Company  announced  that its Board of  Directors  had
authorized it to repurchase from time to time through  open-market  transactions
up to 1,500,000  shares of the Company's Common Stock. As of March 31, 1997, the
Company  had  repurchased  142,500  shares for an  aggregate  purchase  price of
approximately  $2,619,000,  of which 13,665  shares were  re-issued  pursuant to
employee  stock  option  and  stock  purchase   plans.   Such   repurchases  and
re-issuances are recorded as treasury stock transactions.

     On May 9, 1997, the Company  purchased in private  transactions  from Swiss
Bank  Corporation,  London  Branch  ("SBC")  capped call options on  Interneuron
Common Stock. These call options give Interneuron the right to purchase from SBC
up to a total of 1,240,000 shares of Interneuron  Common Stock at a strike price
of $17.75. The call options are exercisable only at their maturities,  which are
September  24, 1997,  March 9, 1998,  May 21, 1998 and August 24, 1998 each with
respect to 310,000 shares, and are subject to caps of $26.00, $34.00, $38.00 and
$40.00,  respectively,  which limit the economic benefit to the Company of these
call options.  The call options  which the Company  purchased are expected to be
settled,  if exercised,  with cash in an amount equal to the difference  between
the  strike  price and the  market  price,  subject to caps which will limit the
total amount of cash the Company  could receive or increase the strike prices in
the case of stock settlement when the market price of the Company's Common Stock
exceeds the applicable cap price.

     In  exchange  for the  purchases  of these  call  options,  in lieu of cash
purchase prices,  the Company sold to SBC call options entitling SBC to purchase
from the  Company  at a strike  price of  $40.30  per  share,  an  aggregate  of
2,000,000 shares of Interneuron Common Stock, 1,000,000 shares on each of May 21
and May 24,  1999.  The Company will have the right to settle these call options
with cash or stock,  subject to certain  conditions.  If exercised,  the Company
expects to settle the call options that it sold through issuances by the Company
to SBC of up to an  aggregate  of 2,000,000  authorized  and unissued  shares of
Common Stock, subject to the effectiveness of a registration  statement covering
the resale of these shares. The sale or potential sale of such shares could have
an adverse effect on the market price of the Company's Common Stock.

     SBC has  advised  that it has  engaged,  and may engage,  in  transactions,
including buying and selling shares of the Company's Common Stock, to offset its
risk relating to the options.  Purchases and sales could affect the market price
of the Company's Common Stock.


     In  February  1997,  the  Company  entered  into a new five year  lease for
approximately  42,000 square feet of space in its current facility in Lexington,
MA to accommodate  current needs and expected  growth.  Total  aggregate  rental
payments under this five year lease is approximately  $3,400,000.  Additionally,
the Company is expending  approximately  $1,000,000 of build-out  costs for this
space.

     The Company's strategy includes evaluation of various  technology,  product
or  company  acquisition  and/or  financing  opportunities   (including  private
placements  and  initial and  follow-on  equity  offerings)  and the Company and
certain of its subsidiaries are currently engaged in


                                      -17-





discussions relating to such opportunities. Any such initiatives may involve the
issuance of securities  of  Interneuron  or its  subsidiaries  and/or  financial
commitments and would result in increased expenses for research and development,
on a consolidated basis.

     While the Company  believes it has  sufficient  cash for currently  planned
expenditures in fiscal 1997, it may seek  additional  funds through other equity
and/or debt financings and corporate  collaborations  to provide working capital
financing  and funding for new  business  opportunities  and future  growth.  In
addition,  certain  subsidiaries  are exploring  various  financings  (including
issuances  of  securities  of the  subsidiaries,  possibly in  combination  with
securities  of  Interneuron,   in  public  offerings  or  private   placements),
collaborations  or business  combinations.  If such efforts are not  successful,
certain activities at these subsidiaries may be reduced.

     Although  Interneuron may acquire additional equity in subsidiaries through
participation in financings, purchases from third parties, including open market
purchases and conversion of intercompany debt, equity financings by a subsidiary
will likely reduce  Interneuron's  percentage  ownership of that  subsidiary and
funds held by the  subsidiaries  will generally not be available to Interneuron.
The Company's goal is for its subsidiaries to establish  independent  operations
and financing through corporate alliances,  third-party  financings,  mergers or
other business  combinations,  with Interneuron  generally  retaining an ongoing
equity  interest.  The  nature  of any  such  transaction  is  expected  to vary
depending on the business and capital needs of each  subsidiary and the state of
development of their respective technologies or products.

     Subsidiaries:

     Interneuron is currently  funding  operations of Progenitor,  Transcell and
InterNutria.  Expenses  of the  Subsidiaries,  including  those  required  under
collaboration agreements, constitute a significant part of the Company's overall
expenses. The Subsidiaries' portion of consolidated research and development and
selling, general and administrative expenses in the six month period ended March
31, 1997 was approximately 39%.

     Intercardia

     Pursuant to the Astra Merck  Collaboration,  Intercardia  has agreed to pay
Astra Merck  $10,000,000 in December 1997 and up to $11,000,000 for one-third of
product launch costs for bucindolol incurred beginning when Intercardia files an
NDA with the FDA for the  twice-daily  formulation  of bucindolol and continuing
through  the first 12 months  subsequent  to the  first  commercial  sale of the
formulation.  In the event  Intercardia  elects not to make these payments,  the
royalties payable by Astra Merck to Intercardia would be substantially  reduced.
There can be no  assurance  of the  success of the  Beta-blocker  Evaluation  of
Survival  Trial  (the  "BEST  Study") or that  bucindolol  will be  successfully
commercialized.  A substantial  portion of the bucindolol  development costs are
being assumed and paid by the National  Institutes of Health,  the Department of
Veterans Affairs, Astra Merck and Knoll.

     Pursuant  to the  Knoll  Collaboration  (see  Note D of Notes to  Unaudited
Consolidated Financial Statements), Intercardia is responsible for approximately
40% of the development and marketing costs of bucindolol in the Territory, which
includes  all  countries  other  than the United  States  and Japan,  subject to
certain maximum dollar limitations. The Company's portion of development and

                                      -18-





clinical  trial costs for the  Territory is  estimated to be up to  $10,000,000.
Intercardia  is  also  responsible  for  approximately  40%  of  the  once-daily
development  costs which  relate to  development  solely for the  Territory  and
approximately  67% of  once-daily  development  costs  which  have  a  worldwide
benefit.

     In  February  1997,  an FDA  advisory  committee  recommended  that the FDA
approve the use of carvedilol,  a competitive drug being developed by SmithKline
Beecham for the treatment of congestive heart failure.  The Company is unable to
predict  the final  labeling  for this  product or the impact of this product on
bucindolol, if it is approved by the FDA.

     Progenitor

     In December 1996, Progenitor entered into an agreement with Amgen, granting
Amgen certain  exclusive  rights for the  development and  commercialization  of
products using Progenitor's leptin receptor technology.  Amgen paid Progenitor a
$500,000  initial  license fee in January 1997,  which was reflected in contract
and license fee revenue in the six month period ended March 31, 1997. Progenitor
may also  receive  from  Amgen  certain  development  and  regulatory  milestone
payments  and  potential  royalties  on sales.  Amgen  also  agreed to  purchase
Progenitor Common Stock in the event of a Progenitor initial public offering.

     In February 1997,  Progenitor  announced an agreement to acquire  Mercator,
Inc.  ("Mercator")  a  privately-held  genomics  company,   subject  to  certain
conditions, including completion of an initial public offering by Progenitor for
approximately   $22,000,000   payable  in  Progenitor  common  stock,  plus  the
assumption of Mercator  liabilities.  Progenitor also agreed to provide Mercator
with an interim  operating line of credit through July 1997 of up to $6,600,000,
funding for which will be provided by Interneuron.  At March 31, 1997,  advances
under this line of credit totaled approximately  $1,300,000 and are reflected in
prepaids and other current assets.

     In March 1997, Progenitor filed registration statements with the Securities
and  Exchange  Commission  relating  to a proposed  initial  public  offering of
2,750,000  shares of Progenitor  common stock (plus up to an additional  412,500
shares to cover  over-allotments)  and the proposed acquisition by Progenitor of
Mercator.  Based on the  proposed  terms of the  offering  and the  acquisition,
assuming  completion of the offering and the Mercator  acquisition  on the filed
terms, Interneuron will own approximately 43% of Progenitor's outstanding common
stock, without giving effect to any exercise of the over-allotment option or any
options  or  warrants,  and  subject  to  change  based  upon the  timing of the
offering,  the  offering  price,  the  number  of  Progenitor  shares  issued in
connection  with  the  Mercator  acquisition  and  the  amount  of  Progenitor's
indebtedness to Interneuron. In connection with the acquisition, Progenitor will
incur  non-recurring  charges to  operations  currently  estimated  to aggregate
approximately $30,000,000, a portion of which are noncash charges related to the
purchase of in-process research and development,  subject to increase based upon
several  factors  including  the timing of the  transactions  and  unanticipated
costs.  Due to market  conditions and other factors,  there is no assurance that
Progenitor's  initial  public  offering  or  acquisition  of  Mercator  will  be
completed, in which case Progenitor will incur charges to operations for amounts
expended in  connection  with the two  proposed  transactions,  including  funds
advanced  under the line of credit.  Interneuron  will record a portion of these
charges based on its ownership interest in Progenitor.

     If Progenitor does not complete its initial public offering and acquisition
of Mercator,  the  $1,300,000  advanced to Mercator under the line of credit and
the  approximately  $1,700,000 of  expenditures  relating to the initial  public
offering at March 31,  1997,  plus  additional  amounts  advanced  and  expended
subsequent to March 31, 1997, will result in charges to operations.

                                      -19-



     Transcell

     Transcell has committed to spend  approximately  $800,000 in fiscal 1997 to
build-out certain  newly-leased  facilities.  At March 31, 1997, the Company had
outstanding  a Standby  Letter of Credit for $800,000 to secure these  build-out
costs.  This Standby  Letter of Credit is  collateralized  by a  certificate  of
deposit  and  expires  the  sooner  of  September  15,  1997 or  receipt  by the
subsidiary's landlord of payment of the build-out costs.

     InterNutria

     InterNutria  is assessing  data from a clinical  evaluation  of PMS Escape.
Depending upon the results of this assessment, the test launch of PMS Escape and
the  availability or allocation of sufficient  funds, the Company will determine
whether to  commence  a  commercial  launch of PMS  Escape,  conduct  additional
clinical trials or evaluations, or discontinue clinical or marketing efforts.




                                      -20-




PART II - OTHER INFORMATION

Item 4.   Submission of Matters to a Vote of Security Holders

     The Company's  annual meeting of stockholders was held on March 5, 1997. At
the  meeting (i) all ten  director  nominees  were  elected;  (ii) the  proposed
amendment  to the Amended  and  Restated  Certificate  of  Incorporation  of the
Company increasing from 60,000,000 to 80,000,000 the number of authorized shares
of Common Stock was approved and ratified;  (iii) the amendment to the Company's
1994  Long-Term  Incentive  Plan,  as  amended,  increasing  from  3,000,000  to
6,000,000  the  number of  shares of Common  Stock  reserved  for  issuance  was
approved and ratified;  and (iv) the  appointment of Coopers & Lybrand L.L.P. as
the independent auditors was ratified.

(i) The  following  Directors  were  elected  for a  one-year  term by the votes
indicated:

Lindsay A. Rosenwald,  M.D.,  38,644,309 for, 312,239 against;  Glenn L. Cooper,
M.D.,  38,646,840 for, 309,708 against;  Harry J. Gray,  38,642,945 for, 313,603
against;  Alexander M. Haig, Jr., 38,640,145 for, 316,403 against;  Peter Barton
Hutt, 38,005,120 for, 951,428 against; Malcolm Morville,  Ph.D., 38,647,040 for,
309,508  against;  Robert K.  Mueller,  38,642,840  for,  313,708  against;  Lee
J.Schroeder, 38,643,940 for, 312,608 against; David B. Sharrock, 38,646,540 for,
310,008 against; Richard Wurtman, M.D., 38,647,040 for, 309,508 against.

(ii) The amendment to the Amended and Restated  Certificate of  Incorporation of
the Company  increasing  from  60,000,000 to 80,000,000 the number of authorized
shares of Common Stock was approved  and ratified by a vote of  38,106,270  for,
1,185,306 against, and 124,915 abstain.

(iii) The amendment to the Company's 1994 Long-Term  Incentive Plan, as amended,
increasing  from  3,000,000  to  6,000,000  the  number of shares  reserved  for
issuance,  was  approved  and ratified by a vote of  25,466,836  for,  5,310,408
against, and 151,590 abstain.

(iv) The  appointment  of Coopers & Lybrand  L.L.P.  was  ratified  by a vote of
39,474,226 for, 35,332 against, and 69,211 abstain.

Item 6.       Exhibits and Reports on Form 8-K

<TABLE>
<CAPTION>
(a)           Exhibits
              --------

<S>                 <C>                                                                                   
3.5           -       Restated Certificate of Incorporation of Registrant, as amended
10.65(a)      -       1994 Long-Term Incentive Plan, as amended (1)
10.89         -       Form of ISDA Master Agreement by and between the Registrant and Swiss
                      Bank Corporation, London Branch, together with Schedules thereto
10.90(a)      -       Form of Confirmation for Contract A entered into pursuant to ISDA Master
                      Agreement by and between the Registrant and Swiss Bank Corporation,
                      London Branch together with appendix thereto.
10.90(b)      -       Form of Confirmation for Contract B entered into pursuant to ISDA Master
                      Agreement by and between the Registrant and Swiss Bank Corporation,
                      London Branch together with appendix thereto.
10.91         -       Form of Agreement regarding Registration Rights and Related Obligations to


                                      -21-





                      be entered into by and between Registrant and Swiss Bank
                      Corporation, London Branch
27            -       Financial Data Schedule

</TABLE>
- ----------------

(1)  amends and supersedes Exhibit 10.65

(b)  Reports on Form 8-K

     The Company filed Reports on Form 8-K reporting  information under "Item 5"
     on January 7, 1997, February 18, 1997, March 14, 1997 and May 6, 1997.




                                      -22-









                                   SIGNATURES


         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned thereunto duly authorized.


                                     INTERNEURON PHARMACEUTICALS, INC.



Date: May 14, 1997                        By: /s/ Glenn L. Cooper, M.D.,
                                             --------------------------------
                                          Glenn L. Cooper, M.D., President
                                          and Chief Executive Officer
                                          (Principal Executive Officer)


Date: May 14, 1997                        By: /s/ Thomas F. Farb
                                             ---------------------------------
                                          Thomas F. Farb,
                                          Executive Vice President, Finance
                                          Chief Financial Officer and Treasurer
                                          (Principal Financial Officer)


Date: May 14, 1997                        By: /s/ Dale Ritter
                                             ---------------------------------
                                          Dale Ritter
                                          Vice President, Corporate Controller
                                          (Principal Accounting Officer)





                                      -23-


                                                                     EXHIBIT 3.5



                            CERTIFICATE OF AMENDMENT

                                     OF THE

              AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF

                        INTERNEURON PHARMACEUTICALS, INC.

 Pursuant to Section 242 of the General Corporation Law of the State of Delaware
                        --------------------------------


It is hereby certified that:

FIRST:     The name of the Corporation is Interneuron Pharmaceuticals, Inc.

SECOND:    The Corporation hereby amends its Amended and Restated Certificate of
           Incorporation as follows:

           Paragraph  (A)(1) of  Article  FOURTH  of the  Amended  and  Restated
           Certificate of Incorporation relating to the authorized capital stock
           of the Corporation,  is hereby deleted in its entirety and amended to
           read as follows:

           The  aggregate  number of shares  which the  Corporation  shall  have
           authority to issue is eighty-five million (85,000,000), of which five
           million  (5,000,000) shares of the par value of $.001 per share shall
           be  designated  "Preferred  Stock"  and eighty  million  (80,000,000)
           shares of the par value of $.001 shall be designated "Common Stock".

THIRD:     This  Certificate  of Amendment  has been duly adopted in  accordance
           with the provisions of Section 242 of the General  Corporation Law of
           the State of Delaware.

         IN  WITNESS  WHEREOF,  the  undersigned,  being  the  President  of the
Corporation, hereunto signs his name and affirms that the statements made herein
are true under the penalties of perjury, this 5th day of March, 1997.

                                                  /s/ Glenn L. Cooper
                                                 -------------------------
                                                 Glenn L. Cooper, M.D.
                                                 President

                                                              





                     CERTIFICATE OF DESIGNATION ESTABLISHING
                            SERIES C PREFERRED STOCK

                                       OF

                        INTERNEURON PHARMACEUTICALS, INC.

                  INTERNEURON PHARMACEUTICALS, INC., a corporation organized and
existing under the General Corporation Law of the State of Delaware,

                  DOES HEREBY CERTIFY:

                  That,  pursuant  to  authority  conferred  upon  the  Board of
Directors by the Certificate of Incorporation,  as amended, of said corporation,
and pursuant to the provisions of Section 151 of the General  Corporation Law of
the State of Delaware,  said Board of Directors,  by unanimous  written  consent
dated May 27, 1993, adopted a resolution providing for the number,  designation,
powers and  preferences,  and the  qualifications,  limitations and restrictions
thereof, of a series of Preferred Stock, which resolution is as follows:

                  "RESOLVED,  that pursuant to the authority vested in the Board
                  of  Directors  in  accordance   with  the  provisions  of  its
                  Certificate  of  Incorporation,   as  amended,   a  series  of
                  Preferred  Stock  of  this   corporation   (hereinafter,   the
                  "Company")   be  and  it  hereby  is   created.   The  number,
                  designation,   powers  and   preferences,   and  the   rights,
                  qualifications,  limitations and restrictions of the shares of
                  such series of Preferred Stock are as follows:

                            Series C Preferred Stock.
                            -------------------------

                  1. Designation. The number of shares to constitute such series
of Preferred  Stock shall be 5,000 and the  designation  of such series shall be
Series C Preferred Stock (hereinafter called the "Series C Stock").

                  2.  Voting  Rights.  On all  matters  submitted  to a vote  of
stockholders  generally,  other than the  election of  Directors,  each share of
Series C Stock  will be  entitled  to a number of votes  equal to the  number of
shares  of  Common  Stock  into  which  such  share  of  Series  C Stock is then
convertible,  and rounding  the result to the nearest  whole  number.  Except as
otherwise  required by law or by any provision hereof,  the Common Stock and the
Series C Stock  will vote  together  as a single  class on all  matters on which
stockholders shall be entitled to vote.


                                       -2-




               3. Conversion.

                  (a) Conversion Ratio. Each outstanding share of Series C Stock
will be  convertible  at any time at the option of the  holder  into a number of
shares of Common Stock computed by dividing $100.00 by the Conversion Price then
in effect.

                  (b) Conversion Price; Adjustment. The initial Conversion Price
will be $13.0125.  Each time after the effective date hereof, the Company issues
or agrees to issue any  additional  shares of Common  Stock for a  consideration
which is less than  two-thirds  of the then  Conversion  Price  per share  (such
consideration being hereinafter  collectively referred to as the "Issue Price"),
the then Conversion Price shall be reduced to 150% of the Issue Price.

                  (c) Excluded Issuances.  The reduction in the Conversion Price
required  by  paragraph  3 (b) shall  not be made in the  event (i) the  Company
issues  shares of Common Stock or options,  warrants or other rights to purchase
Common  Stock  to any of its  officers,  directors,  employees,  consultants  or
scientific  advisers;  (ii) of any issuance of up to 10,000  shares (as adjusted
from time to time pursuant to the  provisions of paragraph 3(e) below) of Common
Stock or Options or  warrants  to purchase up to said number of shares of Common
Stock to any person at any one time,  provided that no more than an aggregate of
100,000  shares (as adjusted  from time to time  pursuant to the  provisions  of
paragraph  3(e) below) and options or warrants to purchase said number of shares
may be issued  pursuant to this clause (ii);  or (iii) of any issuance of Common
Stock,  Options or  Convertible  Securities  (as  defined in  paragraph  3(d)(i)
hereof)  in  respect  of an  obligation  incurred  by the  Company  prior to the
effective date hereof.

                  (d) Effect on Conversion Price of Certain Events. For purposes
of  determining  the Issue Price and the Conversion  Price under  paragraph 3(b)
above, the following will apply:

                        (i)  Issuance of Rights or Options.  Each time after the
effective  date  hereof,  the  Company in any  manner  (other  than an  excluded
issuance under  paragraph 3(c)) grants any rights or options to subscribe for or
to purchase Common stock or any stock or other  securities  convertible  into or
exchangeable  for Common  Stock  (such  rights or options  being  herein  called
"Options" and such convertible or exchangeable  stock or securities being herein
called "Convertible  Securities") and the price per share for which Common Stock
is issuable upon the exercise of such Options or upon  conversion or exchange of
such  Convertible  Securities  is less than both (x) 150% of the  average of the
last sale prices for the Common  Stock for the ten trading  days  preceding  the
date on which the Company  issues or agrees to issue such Options or Convertible
Securities and (y) the then Conversion Price, then the Conversion Price shall be
reduced to the greater of (x) 100% of the price per share for which Common Stock
is issuable upon the exercise of such Options or upon  conversion or exchange of
such  Convertible  Securities and (y) 56.67% of the initial  Conversion Price as
adjusted from time to time pursuant to the  provisions of paragraph  3(e) below.
For purposes of this  paragraph , the "price per share for 


                                       -3-





which  Common  Stock is  issuable  upon the  exercise  of such  Options  or upon
conversion  or exchange of such  Convertible  Securities"  will be determined by
dividing (A) the total amount,  if any, received or receivable by the Company as
consideration for the granting of such Option or upon the conversion or exchange
of all such  Convertible  issuable upon the exercise of such  Options,  plus the
minimum aggregate amount of additional consideration payable to the Company upon
exercise of all such Options,  plus, in the case of such Options which relate to
Convertible   Securities,   the   minimum   aggregate   amount   of   additional
consideration,  if any, payable to the Company upon the issuance or sale of such
Convertible  Securities and the conversion or exchange thereof, by (B) the total
maximum  number of shares of Common  Stock  issuable  upon the  exercise of such
Options.   Except  as  otherwise  provided  in  paragraph  3(d)(iii)  below,  no
adjustment of the Conversion Price will be made when Convertible  Securities are
actually  issued  upon the  exercise  of such  Options or when  Common  Stock is
actually  issued upon the exercise of such Options or the conversion or exchange
of such Convertible Securities.

                        (ii) Issuance of Convertible Securities. Each time after
the  effective  date hereof,  the Company in any manner  (other than an excluded
issuance under paragraph 3(c) issues or sells any Convertible Securities and the
price per share for which  Common  Stock is  issuable  upon such  conversion  or
exchange  is less than both (x) 150% of the  average of the last sale prices for
the  Common  Stock  for the ten  trading  days  preceding  the date on which the
Company issues or agrees to issue such Options or Convertible Securities and (y)
the then  Conversion  Price,  then the Conversion  Price shall be reduced to the
greater of (x) 100% of the price per share for which  Common  Stock is  issuable
upon such conversion or exchange and (y) 56.67% of the initial  Conversion Price
as adjusted  from time to time  pursuant to the  provisions  of  paragraph  3(e)
below. For the purposes of this paragraph, the "price per share for which Common
Stock is issuable  upon such  conversion  or  exchange"  will be  determined  by
dividing  (A)  the  total  amount  received  or  receivable  by the  Company  as
consideration for the issuance or sale of such Convertible Securities,  plus the
minimum  aggregate  amount of additional  consideration,  if any, payable to the
Company upon the conversion or exchange thereof, by (B) the total maximum number
of shares of Common Stock  issuable upon the  conversion or exchange of all such
Convertible  Securities.  Except as otherwise  provided in  paragraph  3(d)(iii)
below,  no adjustment of the Conversion  Price will be made when Common Stock is
actually issued upon the conversion or exchange of such Convertible  Securities,
and if any  such  issue  or sale of such  Convertible  Securities  is made  upon
exercise of any Options for which  adjustments of the Conversion  Price had been
or are to be made pursuant to other  provisions of this  paragraph 3, no further
adjustment of the Conversion Price will be made by reason of such issue or sale.

                        (iii) Change in Option Price or Conversion  Rate. If the
purchase price provided for in any Option, the additional consideration, if any,
payable upon the conversion or exchange of Convertible  Securities,  or the rate
at which any  Convertible  Securities are convertible  into or exchangeable  for
Common  Stock,  change at any time (other than under or by reason of  provisions
designed to protect  against  dilution of the type set forth in this paragraph 3
or any other  mandatory  anti-dilution  provisions  contained in such Options or
Convertible

                                       -4-




Securities)  the  Conversion  Price in effect at the time of such change will be
readjusted to the Conversion  Price which would have been in effect at such time
had such Options or Convertible  Securities still outstanding  provided for such
changed purchase price, additional consideration or changed conversion rates, as
the case may be, at the time initially granted,  issued or sold; provided,  that
such adjustment of the Conversion Price then in effect would be reduced.  If the
purchase price provided for in any Option, the additional consideration, if any,
payable upon the conversion or exchange of any  Convertible  Securities,  or the
rate at which any Convertible  Securities are  convertible  into or exchangeable
for Common Stock,  is reduced at any time under or by reason of provisions  with
respect  thereto  designed  to protect  against  dilution  of the type set forth
herein or any other mandatory  anti-dilution provision contained in such Options
or Convertible Securities, then in the case of the delivery of Common Stock upon
the exercise of any such Option or upon the  conversion  or exchange of any such
Convertible  Security,  the  Conversion  Price  then in  effect  hereunder  will
forthwith be adjusted to such respective  amount as would have been obtained had
such Option or  Convertible  Security  never been issued as to such Common Stock
and had adjustments  been made to the Conversion  Price upon the issuance of the
shares of Common Stock  delivered,  but only if as a result of such  adjustment,
the Conversion Price then in effect hereunder would be reduced.

                        (iv) Calculation of Consideration  Received. In case any
Common Stock, Options or Convertible  Securities are issued or sold or deemed to
have been issued or sold for  consideration,  part or all of which is cash,  the
amount of cash  consideration  received  therefor will be deemed to be the gross
amount received by the Company  therefor.  In case any Common Stock,  Options or
Convertible  Securities are issued or sold or deemed to have been issued or sold
for a consideration,  part or all of which is other than cash, the amount of the
consideration  other than cash received by the Company will be the fair value of
such  consideration,  except  where such  consideration  consists of  securities
publicly  traded,  in which case the  amount of  consideration  received  by the
Company will be the market price thereof as of the date of receipt.  In case any
Common Stock,  Options or Convertible  Securities are issued in connection  with
any merger in which the  Company  is the  surviving  corporation,  the amount of
consideration  therefor  will be deemed to be the fair value of such  portion of
the net assets and business of the non-surviving  corporation as is attributable
to such Common Stock, Options or Convertible Securities, as the case may be.

                        (v) Integration of  Transactions.  In case any Option or
Convertible  Security  is issued in  connection  with the issue or sale of other
securities of the Company,  together  comprising one  integrated  transaction in
which no specific  consideration  is  allocated  to such  Option or  Convertible
Security by the parties  thereto,  the Option or  Convertible  Security  will be
deemed to have been issued without consideration.

                    (e)  Subdivision  or  Combination  of Common  Stock.  If the
Company at any time subdivides (by any stock split, stock dividend or otherwise)
its  outstanding  shares of Common  Stock into a greater  number of shares,  the
Conversion  Price  in  effect  immediately  prior  to such  subdivision  will be
proportionately reduced, and if the Company at any time


                                       -5-




combines (by reverse stock split or otherwise) its outstanding  shares of Common
Stock  into  a  smaller  number  of  shares,   the  Conversion   Price  will  be
proportionately increased.

                    (f) Reorganization, Reclassification, Merger, Consolidation,
or Sale.  If any  capital  reorganization,  reclassification,  consolidation  or
merger  or any  sale  of  all or  substantially  all  of  the  Company's  assets
(collectively  any "Major  Change") is  effected  in such a way that  holders of
Common  Stock are  entitled  to  receive  (either  directly  or upon  subsequent
liquidation)  stock,  other  securities or assets with respect to or in exchange
for Common Stock, then, as a condition to such Major Change, lawful and adequate
provision  will be made,  whereby  each of the  holders  of Series C Stock  will
thereafter  have the right to  acquire  and  receive,  in lieu of the  shares of
Common  Stock  immediately   theretofore  acquirable  and  receivable  upon  the
conversion  of such  holder's  Series C  Stock,  such  shares  of  stock,  other
securities  or  assets as may be  issuable  or  payable  with  respect  to or in
exchange  for the  number  of shares of  Common  stock  immediately  theretofore
acquirable and receivable  upon  conversion of such holder's  Series C Stock had
such Major Change not taken place. In any such case,  appropriate provision will
be made with respect to such  holder's  rights and interests to the end that the
provisions  of this  paragraph  3 and  paragraph  4  below  will  thereafter  be
applicable in relation to any shares of stock,  securities or assets  thereafter
deliverable upon the conversion of Series C Stock including,  in the case of any
such  consolidation,  merger  or sale in  which  the  successor  corporation  or
purchasing corporation is other than the Company, an immediate adjustment of the
Conversion  Price to the value for the Common  Stock  reflected  by the terms of
such consolidation,  merger or sale and a corresponding  immediate adjustment in
the number of shares of Common Stock  acquirable and receivable  upon conversion
of Series C Stock,  if the value so reflected is less than the Conversion  Price
in effect immediately prior to such  consolidation,  merger or sale. The Company
will not  effect any such  consolidation,  merger or sale  unless,  prior to the
consummation  thereof,  the  successor  corporation  (if other than the Company)
resulting from such consolidation or merger, or the corporation  purchasing such
assets,  assumes, by written instrument,  the obligation to deliver to each such
holder such shares of stock,  securities  or assets as, in  accordance  with the
foregoing provisions, such holder may be entitled to acquire.

                    (g)  Certain  Events.  If  any  event  occurs  of  the  type
contemplated  by the provisions of this paragraph 3, but not expressly  provided
for by such  provisions,  then the Board of Directors  will make an  appropriate
adjustment in the Conversion Price so as to protect the rights of the holders of
Series C Stock.

                    (h)  No  Circumvention.  The  Company  will  not  issue  any
additional  shares of Series C Stock or, in  circumvention  of the provisions of
this  paragraph  3, issue any shares of preferred  stock which,  notwithstanding
such designation,  primarily possess the attributes  customarily associated with
common stock,  and do not possess  special voting rights,  scheduled or optional
redemption  features (with redemption  prices specified as to amount and limited
to such amount),  special liquidation rights fixed and limited as to amount, and
dividends  fixed in amount  and  limited  to the  amount so  fixed,  other  than
pursuant  to an  obligation  to  issue  preferred  stock  existing  prior to the
effective date hereof.


                                       -6-




                    (i) Notices.

                        (i) As soon as  practicable  after any adjustment of the
Conversion Price, the Company will send written notice thereof to all holders of
Series C Stock.

                        (ii) The  Company  will give to the  holders of Series C
Stock at least 20 days'  prior  written  notice  of the date on which  any Major
Change, dissolution or liquidation will take place.

                    (j) Mechanics of Conversion. So long as any shares of Series
C Stock remain  outstanding,  at the election of the respective holders thereof,
any and all  shares of the  Series C Stock may be  converted  at any time on and
subsequent to the second  anniversary of initial  issuance and from time to time
into the number of fully paid and  non-assessable  shares of Common Stock of the
Company  calculated  as set forth  herein.  In order to exercise the  conversion
privilege, the holder of Series C Stock shall surrender the certificates for the
Series C Stock to be converted at the offices of the Company in the Commonwealth
of  Massachusetts,  together with written  notice to the Company that the holder
elects to convert  such Series C Stock or a portion  thereof.  Such notice shall
also state the name or names (with address) in which the certificates for shares
of Common  Stock  issuable on such  conversion  shall be issued.  Series C Stock
surrendered for conversion shall be accompanied by proper assignments thereof to
the company or in blank for  transfer  and the  signature of the holder shall be
guaranteed by a firm having  membership  on the New York Stock  Exchange or by a
commercial  bank or trust company  located in or having a  correspondent  in the
City of New York, and such conversion shall be deemed effective upon the date of
delivery  of  such  certificates  in  accordance  with  the  provisions  of this
subdivision (j).

                        (k)  Fractional  Shares;  Dividends  on  Conversion.  No
fractional  shares of Common Stock will be issuable upon  conversion of Series C
Stock.  The Company in lieu thereof,  will make a payment in cash in lieu of any
fractional  share of  Common  Stock  to which  the  converting  holder  would be
entitled if such fractional share was issuable, based upon the market price of a
share of Common  Stock as of the  Conversion  Date.  Upon such  conversion,  the
Company  will pay all accrued but unpaid  dividends  with  respect to each share
converted which have not been paid theretofore.

                  4.    Dividends.

                        (a) The  annual  dividend  rate at which the  holders of
shares shall be entitled to receive  dividends is $1.00 per share per annum. The
holders  of the  shares  shall be  entitled  to  receive,  out of funds  legally
available  therefor  under  Section  170  (or  its  successor)  of the  Delaware
Corporation Law,  mandatory  preferential  dividends at such annual rate payable
annually on the first day of April in each year. Such dividends shall be accrued
on a daily basis and shall be cumulative.


                                       -7-




                        (b) The Board of Directors shall pay dividends,  in cash
or, at the  election  of the  Board of  Directors,  in  shares of Common  Stock,
including  dividends  accrued  under  paragraph  (a) but  unpaid on any share of
Series C Stock  as of the date on which  such  share is  converted  into  Common
Stock. If paid in Common Stock, the dividend shall be paid by delivering  shares
of Common Stock to, and  registered  on the books of the Company in the name of,
the  registered  holder of the share of Series C Stock on the record date or the
date of  conversion,  as the case may be.  The  number of such  shares of Common
Stock so deliverable shall be that number of whole shares which, when multiplied
by the "per-share value"  determined below,  shall equal the total amount of the
dividend then due.  "Per-share  value" shall be equal to the average of the last
sale prices of Common Stock on the National  Association  of Securities  Dealers
Automated Quotation System for the ten days immediately  preceding such dividend
payment date or, if during which the Common Stock is then listed on any national
securities  exchange,  the average of the closing prices on the primary exchange
during  such ten days.  No  fractional  shares  will be issued in payment of any
dividend  contemplated by this paragraph  4(b). In lieu thereof,  there shall be
paid,  simultaneously with the distribution of the whole shares of Common Stock,
cash in the amount of the "per share value" of any fractional share.

                        (c) If the  Company  declares  a  distribution  upon the
Common  Stock,  other than a  distribution  payable  entirely  in Common  Stock,
payable  otherwise  than  out  of  earnings  or  earned  surplus  determined  in
accordance with generally accepted accounting  principles,  consistently applied
(a "Liquidating Dividend"), then the Company will pay to each holder of Series C
Stock at the time of payment of a  Liquidating  Dividend an amount  equal to the
aggregate value of all  Liquidating  Dividends which would have been paid on the
Common Stock issuable upon conversion of such holder's Series C Stock,  had such
Common Stock been converted  immediately prior to the date on which a record was
taken for such Liquidating Dividend,  or, if no record was taken, the date as of
which the  record  holders  of Common  Stock  entitled  to such  dividends  were
determined.  For purposes of this  paragraph  4, a dividend  other than in cash,
notes,  debentures  or  capital  stock  will not be  considered  payable  out of
earnings  or earned  surplus,  regardless  of whether or not  earnings or earned
surplus  are  charged  an amount  equal to the fair value of such  dividend.  No
distribution  in respect of Series C Stock  contemplated  by this paragraph 4(c)
shall be deemed to reduce  the amount of  dividends  then  cumulated  but unpaid
under paragraph 4(a).

                        (d)  Except  as   contemplated  by  paragraph  4(c),  no
dividend or  distribution  will be declared or paid on the Common Stock when any
dividends contemplated by paragraph 4(a) are cumulated but unpaid.

         5.  Preference  on  Liquidation.  The  preference  per share  which the
holders of Series C  Preferred  Stock  shall be  entitled  to  receive  over the
holders of each share of Common Stock and each share of  Preferred  Stock (other
than the shares of any other series of Preferred Stock  initially  issued in its
entirety to American Cyanamid  Company,  which series shall rank pari passu with
Series C  Stock),  in case of the  liquidation,  distribution  or sale of all or
substantially  all of the  Company's  assets,  dissolution  or winding up of the
Company,

                                       -8-




whether  voluntary or involuntary,  shall be $100.00 per share plus, in any such
case, an amount equal to any and all dividends cumulated but unpaid.

         6. Protective  Provisions.  Until the date American Cyanamid Company or
its  affiliates  ceases to be the  registered  holder of all of the  issued  and
outstanding  Preferred  Stock of at least  one  series,  the  Company  will not,
without the  approval  by the vote or written  consent of at least a majority of
the outstanding  shares of all series of Preferred Stock initially issued in its
entirety to American Cyanamid Company, voting as a single class:

                  (a) authorize or issue shares of any class of stock having any
preference or priority,  or ranking,  unless issued to American Cyanamid Company
or its designee or to Elan Pharmaceuticals,  plc pursuant to an Option Agreement
dated as of April 22,  1991 as in  effect on June 3,  1993,  pari  passu,  as to
dividends or assets superior to any such series;

                  (b)  reclassify  any shares of any class of stock into  shares
having any preference or priority as to dividends or assets superior to any such
series;

                  (c) make any amendment to its Certificate of  Incorporation or
by-laws adversely affecting the rights of holders of any such series;

                  (d)  merge  or  consolidate  with  any  entity  (other  than a
wholly-owned  subsidiary of the Company),  or sell, lease, mortgage or otherwise
dispose  of  all  of  its  assets,  or  liquidate,  dissolve,   recapitalize  or
reorganize;

                  (e) repurchase or redeem any shares of its Common Stock;

                  (f) pay dividends or make any other distribution on any shares
of Common Stock,  other than a  distribution  payable  entirely in Common Stock,
unless,  simultaneous  with such  payment or  distribution,  the Company pays or
distributes  to each  holder  of Series C Stock at the time of such  payment  or
distribution,  a payment  or  distribution  equal in amount and paid in the same
form as the payment or  distribution  such holder  would have  received had such
holder  converted  its shares of Series C Stock into  Common  Stock  immediately
prior to the record  date for the payment or  distribution  to holders of Common
Stock.  Any  payment or  distribution  pursuant  to this  paragraph  shall be in
addition  to and shall not be deemed to  reduce  the  amount of  dividends  then
cumulated but unpaid under paragraph 4(a); or

                  (g)  guarantee  any  indebtedness  of any third party except a
subsidiary for borrowed money.

                  7.  Amendment.  No amendment of any term of the Series C Stock
may be made  without  the  affirmative  vote of  holders  of at least 2/3 of the
outstanding shares of Series C Stock.


                                       -9-




        This Certificate has been executed on this 3rd day of June 1993.

                                            INTERNEURON PHARMACEUTICALS, INC.



                                            By  /s/ Glenn L. Cooper
                                              --------------------------
                                                      President

Attest:


  /s/ Jill Cohen
- --------------------
  Secretary

                                      -10-




                      RESTATED CERTIFICATE OF INCORPORATION

                                       OF

                        INTERNEURON PHARMACEUTICALS, INC.



                  INTERNEURON  PHARMACEUTICALS,   INC.  (the  "Corporation"),  a
Corporation   organized  and  existing  under  and  by  virtue  of  the  General
Corporation Law of the State of Delaware, hereby certifies as follows:

1.  The  name of the  corporation  is  Interneuron  Pharmaceuticals,  Inc..  The
Corporation  was  originally  incorporated  under  the name  Interneuron  Merger
Corporation  and the original  Certificate of  Incorporation  was filed with the
Secretary of State of the State of Delaware on February 21, 1990.

2. This Restated  Certificate of Incorporation  restates and integrates and does
not further amend the  provisions of the  Certificate  of  Incorporation  of the
Corporation.  This Restated Certificate of Incorporation was adopted pursuant to
Section 245 of the General Corporation Law of the State of Delaware.

3.  Pursuant  to  Section  245 of the  General  Corporation  Law of the State of
Delaware,  the text of the Restated  Certificate of  Incorporation as heretofore
amended or supplemented is hereby restated to read in its entirety as follows:

FIRST:     The name of the Corporation is Interneuron Pharmaceuticals, Inc.

SECOND:    The Corporation is formed to engage in any lawful act or activity for
           which corporations may be organized under the General Corporation Law
           of the State of Delaware.

THIRD:     The  registered  office of the  Corporation  is to be  located  at 32
           Loockerman  Square,  Suite L-100, in the City of Dover, in the County
           of Kent, in the State of Delaware.  The name of its registered  agent
           at that address is The Prentice-Hall Corporation System, Inc.

FOURTH:   (A) (1) The aggregate  number of shares which the  Corporation  shall
           have authority to issue is fifty-five million (55,000,000),  of which
           five million  (5,000,000)  shares of the par value of $.001 per share
           shall be designated  "Preferred Stock" and fifty million (50,000,000)
           shares  of the par  value  of $.001  per  share  shall be  designated
           "Common Stock."


                                      -11-




                           (2)  Authority  is hereby  expressly  granted  to the
                  Board of  Directors  from time to time to issue the  Preferred
                  Stock as Preferred Stock of any series and, in connection with
                  the creation of each such series,  to fix by the resolution or
                  resolutions  providing  for the issue of shares  thereof,  the
                  number of shares of such series and the designations,  powers,
                  preferences,    rights,   qualifications,    limitations   and
                  restrictions  of  such  series,  to  the  full  extent  now or
                  hereafter permitted by the laws of the State of Delaware.

                  (B)      Series B Preferred Stock.

                           (1)  Designation.  The number of shares to constitute
                  such  series  of  Preferred  Stock  shall be  239,425  and the
                  designation  of such series shall be Series B Preferred  Stock
                  (hereinafter called the "Series B Stock").

                           (2) Voting Rights. On all matters submitted to a vote
                  of  stockholders   generally,   other  than  the  election  of
                  Directors,  each share of Series B Stock will be entitled to a
                  number of votes equal to the number of shares of Common  Stock
                  into which  such share of Series B Stock is then  convertible,
                  and rounding the result to the nearest whole number. Except as
                  otherwise  required  by law or by any  provision  hereof,  the
                  Common  Stock and the Series B Stock will vote  together  as a
                  single  class on all  matters on which  stockholders  shall be
                  entitled to vote.

                           (3)      Conversion.

                                    (a) Conversion Ratio. Each outstanding share
                  of  Series  B Stock  will be  convertible  at any  time at the
                  option of the holder  into a number of shares of Common  Stock
                  computed by dividing  $12.53 by the  Conversion  Price then in
                  effect.

                                    (b)  Conversion   Price;   Adjustment.   The
                  initial  Conversion Price will be $12.53.  Each time after the
                  effective  date hereof,  the Company issues or agrees to issue
                  any additional  shares of Common Stock for a consideration per
                  share  which is less than  two-thirds  of the then  Conversion
                  Price  (such  consideration  being  hereinafter   collectively
                  referred to as the "Issue Price"),  the then Conversion  Price
                  shall be reduced to 150% of the Issue Price.

                                    (c) Excluded Issuances. The reduction in the
                  Conversion  Price required by paragraph 3(b) shall not be made
                  in the event (i) the Company  issues shares of Common Stock or
                  options,  warrants or other rights to purchase Common Stock to
                  any of its  officers,  directors,  employees,  consultants  or
                  scientific  advisers;  (ii) of any  issuance  of up to  10,000
                  shares  (as  adjusted  from  time  to  time  pursuant  to  the
                  provisions of paragraph 3(e) below) of Common Stock or options
                  or warrants to purchase up to said number of


                                      -12-




                  shares of Common Stock to any person at any one time, provided
                  that no more than an aggregate of 100,000  shares (as adjusted
                  from time to time pursuant to the provisions of paragraph 3(e)
                  below) and  options or  warrants  to  purchase  said number of
                  shares may be issued pursuant to this clause (ii); or (iii) of
                  any  issuance  of  Common   Stock,   Options  or   Convertible
                  Securities (as defined in paragraph 3(d)(i) hereof) in respect
                  of  an  obligation  incurred  by  the  Company  prior  to  the
                  effective date hereof.

                             (d) Effect on Conversion  Price of Certain  Events.
                  For purposes of determining the Issue Price and the Conversion
                  Price under paragraph 3(b) above, the following will apply:

                                    (i) Issuance of Rights or Options. Each time
                  after the effective date hereof,  the Company,  in any manner,
                  (other than an excluded  issuance under paragraph 3(c)) grants
                  any rights or options to subscribe  for or to purchase  Common
                  Stock or any  stock or other  securities  convertible  into or
                  exchangeable  for Common Stock (such  rights or options  being
                  herein called  "Options" and such  convertible or exchangeable
                  stock  or   securities   being  herein   called   "Convertible
                  Securities") and the price per share for which Common Stock is
                  issuable upon the exercise of such Options or upon  conversion
                  or exchange of such  Convertible  Securities is less than both
                  (x) 150% of the average of the last sale prices for the Common
                  Stock for the ten trading days preceding the date on which the
                  Company  issues or agrees to issue such Options or Convertible
                  Securities  and  (y)  the  then  Conversion  Price,  then  the
                  Conversion  Price  shall be reduced to the greater of (x) 100%
                  of the price per share for which Common Stock is issuable upon
                  the exercise of such Options or upon conversion or exchange of
                  such  Convertible  Securities  and (y)  56.67% of the  initial
                  Conversion Price as adjusted from time to time pursuant to the
                  provisions  of  paragraph  3(e)  below.  For  purposes of this
                  paragraph,  the  "price  per share for which  Common  Stock is
                  issuable upon the exercise of such Options or upon  conversion
                  or exchange of such Convertible Securities" will be determined
                  by  dividing  (A)  the  total  amount,  if  any,  received  or
                  receivable by the Company as consideration for the granting of
                  such Options,  plus the minimum aggregate amount of additional
                  consideration payable to the Company upon exercise of all such
                  Options,  plus,  in the case of such  Options  which relate to
                  Convertible  Securities,   the  minimum  aggregate  amount  of
                  additional consideration,  if any, payable to the Company upon
                  the issuance or sale of such  Convertible  Securities  and the
                  conversion  or  exchange  thereof,  by (B) the  total  maximum
                  number of shares of Common Stock issuable upon the exercise of
                  such  Options or upon the  conversion  or exchange of all such
                  Convertible  Securities  issuable  upon the  exercise  of such
                  Options.  Except as otherwise provided in paragraph  3(d)(iii)
                  below, no adjustment of the Conversion Price will be made when
                  Convertible Securities are actually issued upon the exercise


                                      -13-




                  of such Options or when Common  Stock is actually  issued upon
                  the exercise of such Options or the  conversion or exchange of
                  such Convertible Securities.

                                    (ii)  Issuance  of  Convertible  Securities.
                  Each time after the effective date hereof, the Company, in any
                  manner (other than an excluded issuance under paragraph 3(c)),
                  issues or sells any  Convertible  Securities and the price per
                  share for which Common Stock is issuable upon such  conversion
                  or  exchange  is less than both (x) 150% of the average of the
                  last sale prices for the Common Stock for the ten trading days
                  preceding  the date on which the  Company  issues or agrees to
                  issue such Options or Convertible  Securities and (y) the then
                  Conversion  Price,  then the Conversion Price shall be reduced
                  to the  greater  of (x) 100% of the  price per share for which
                  Common Stock is issuable upon such  conversion or exchange and
                  (y) 56.67% of the initial  Conversion  Price as adjusted  from
                  time to time  pursuant to the  provisions  of  paragraph  3(e)
                  below.  For the  purposes  of this  paragraph,  the "price per
                  share for which Common Stock is issuable upon such  conversion
                  or  exchange"  will be  determined  by dividing  (A) the total
                  amount received or receivable by the Company as  consideration
                  for the issuance or sale of such Convertible Securities,  plus
                  the minimum aggregate amount of additional  consideration,  if
                  any,  payable to the Company upon the  conversion  or exchange
                  thereof,  by (B) the total maximum  number of shares of Common
                  Stock  issuable  upon the  conversion  or exchange of all such
                  Convertible  Securities.   Except  as  otherwise  provided  in
                  paragraph  3(d)(iii)  below,  no adjustment of the  Conversion
                  Price will be made when Common  Stock is actually  issued upon
                  the conversion or exchange of such Convertible Securities, and
                  if any such issue or sale of such  Convertible  Securities  is
                  made upon exercise of any Options for which adjustments of the
                  Conversion  Price had been or are to be made pursuant to other
                  provisions of this  paragraph 3, no further  adjustment of the
                  Conversion Price will be made by reason of such issue or sale.

                                    (iii) Change in Option  Price or  Conversion
                  Rate. If the purchase  price  provided for in any Option,  the
                  additional consideration,  if any, payable upon the conversion
                  or  exchange  of any  Convertible  Securities,  or the rate at
                  which  any  Convertible  Securities  are  convertible  into or
                  exchangeable  for Common  Stock change at any time (other than
                  under or by reason of provisions  designed to protect  against
                  dilution  of the type set  forth in this  paragraph  3, or any
                  other mandatory anti-dilution provision otherwise contained in
                  such Options or Convertible Securities),  the Conversion Price
                  in effect at the time of such change will be readjusted to the
                  Conversion  Price which would have been in effect at such time
                  had such Options or Convertible  Securities still  outstanding
                  provided  for  such   changed   purchase   price,   additional
                  consideration or changed conversion rates, as the case may be,
                  at the time initially granted,  issued or sold; provided, that
                  such  adjustment of the Conversion  Price then in effect would
                  be reduced.  If the purchase price provided for in any Option,
                  the

                                      -14-




                  additional consideration,  if any, payable upon the conversion
                  or  exchange  of any  Convertible  Securities,  or the rate at
                  which  any  Convertible  Securities  are  convertible  into or
                  exchangeable  for Common Stock, is reduced at any time,  under
                  or by reason of,  provisions with respect thereto  designed to
                  protect  against  dilution of the type set forth herein or any
                  other  mandatory  anti-dilution  provision  contained  in such
                  Options  or  Convertible  Securities,  then in the case of the
                  delivery of Common  Stock upon the exercise of any such Option
                  or upon the  Conversion  or exchange  of any such  Convertible
                  Security,  the Conversion  Price then in effect hereunder will
                  forthwith be adjusted to such respective  amount as would have
                  been obtained had such Option or  Convertible  Security  never
                  been issued as to such Common Stock and had  adjustments  been
                  made to the  Conversion  Price upon the issuance of the shares
                  of  Common  Stock  delivered,  but only if as a result of such
                  adjustment,  the  Conversion  Price  then in effect  hereunder
                  would be reduced.

                                    (iv) Calculation of Consideration  Received.
                  In case any Common Stock,  Options or  Convertible  Securities
                  are  issued or sold or deemed to have been  issued or sold for
                  consideration,  part or all of which is cash,  the  amount  of
                  cash consideration  received therefor will be deemed to be the
                  gross  amount  received by the Company  therefor.  In case any
                  Common Stock, Options or Convertible  Securities are issued or
                  sold  or   deemed   to  have   been   issued  or  sold  for  a
                  consideration,  part or all of which is other than  cash,  the
                  amount of the consideration,  other than cash, received by the
                  Company will be the fair value of such  consideration,  except
                  where  such  consideration  consists  of  securities  publicly
                  traded, in which case the amount of consideration  received by
                  the Company,  will be the market price  thereof as of the date
                  of receipt.  In case any Common Stock,  Options or Convertible
                  Securities  are issued in connection  with any merger in which
                  the  Company  is the  surviving  corporation,  the  amount  of
                  consideration  therefor will be deemed to be the fair value of
                  such   portion  of  the  net  assets  and   business   of  the
                  non-surviving  corporation as is  attributable  to such Common
                  Stock, Options or Convertible Securities, as the case may be.

                                    (v) Integration of Transactions. In case any
                  Option or  Convertible  Security is issued in connection  with
                  the issue or sale of other securities of the Company, together
                  comprising  one  integrated  transaction  in which no specific
                  consideration  is  allocated  to such  Option  or  Convertible
                  Security by the  parties  thereto,  the Option or  Convertible
                  Security   will  be  deemed  to  have  been   issued   without
                  consideration.

                            (e)  Subdivision or Combination of Common Stock.  If
                  the Company at any time subdivides (by any stock split,  stock
                  dividend or otherwise) its outstanding  shares of Common Stock
                  into a  greater  number of  shares,  the  Conversion  Price in
                  effect immediately prior to such subdivision

                            
                                      -15-




                  will be  proportionately  reduced,  and if the  Company at any
                  time  combines  (by  reverse  stock  split or  otherwise)  its
                  outstanding  shares of Common  Stock into a smaller  number of
                  shares,   the   Conversion   Price  will  be   proportionately
                  increased.

                                    (f)    Reorganization,     Reclassification,
                  Merger,  Consolidation or Sale. If any capital reorganization,
                  reclassification,  consolidation  or merger or any sale of all
                  or substantially all of the Company's assets (collectively any
                  "Major  Change")  is  effected  in such a way that  holders of
                  Common Stock are entitled to receive (either  directly or upon
                  subsequent liquidation) stock, other securities or assets with
                  respect  to  or in  exchange  for  Common  Stock,  then,  as a
                  condition to such Major Change,  lawful and adequate provision
                  will be made  whereby  each of the  holders  of Series B Stock
                  will  thereafter have the right to acquire and receive in lieu
                  of  the  shares  of  Common  Stock   immediately   theretofore
                  acquirable and receivable upon the conversion of such holder's
                  Series B Stock,  such  shares of stock,  other  securities  or
                  assets as may be  issuable  or payable  with  respect to or in
                  exchange for the number of shares of Common Stock  immediately
                  theretofore  acquirable and receivable upon conversion of such
                  holder's Series B Stock had such Major Change not taken place.
                  In any such  case,  appropriate  provision  will be made  with
                  respect to such holder's  rights and interests to the end that
                  the  provisions of this paragraph 3 and paragraph 4 below will
                  thereafter  be  applicable in relation to any shares of stock,
                  securities   or  assets   thereafter   deliverable   upon  the
                  conversion  of  Series B Stock  including,  in the case of any
                  such  consolidation,  merger  or sale in which  the  successor
                  corporation  or  purchasing  corporation  is  other  than  the
                  Company,  an immediate  adjustment of the Conversion  Price to
                  the value for the Common Stock  reflected by the terms of such
                  consolidation,  merger or sale and a  corresponding  immediate
                  adjustment in the number of shares of Common Stock  acquirable
                  and receivable upon conversion of Series B Stock, if the value
                  so  reflected  is less  than the  Conversion  Price in  effect
                  immediately prior to such  consolidation,  merger or sale. The
                  Company will not effect any such consolidation, merger or sale
                  unless,  prior  to the  consummation  thereof,  the  successor
                  corporation  (if other than the Company)  resulting  from such
                  consolidation  or merger,  or the corporation  purchasing such
                  assets,  assumes  by  written  instrument  the  obligation  to
                  deliver to each such holder  such shares of stock,  securities
                  or assets as, in  accordance  with the  foregoing  provisions,
                  such holder may be entitled to acquire.

                                    (g) Certain  Events.  If any event occurs of
                  the type  contemplated  by the provisions of this paragraph 3,
                  but not expressly  provided for by such  provisions,  then the
                  Board of Directors will make an appropriate  adjustment in the
                  Conversion Price so as to protect the rights of the holders of
                  Series B Stock.


                                      -16-




                                    (h) No  Circumvention.  The Company will not
                  issue  any  additional   shares  of  Series  B  Stock  or,  in
                  circumvention of the provisions of this paragraph 3, issue any
                  shares  of  preferred   stock  which,   notwithstanding   such
                  designation,  primarily  possess  the  attributes  customarily
                  associated  with  common  stock,  and do not  possess  special
                  voting rights, scheduled or optional redemption features (with
                  redemption  prices  specified as to amount and limited to such
                  amount),  special  liquidation  rights fixed and limited as to
                  amount,  and  dividends  fixed in amount  and  limited  to the
                  amount so fixed; other than pursuant to an obligation to issue
                  preferred stock existing prior to the effective date hereof.

                                    (i)     Notices.

                                            (i) As soon as practicable after any
                  adjustment  of the  Conversion  Price,  the Company  will send
                  written notice thereof to all holders of Series B Stock.

                                            (ii) The  Company  will  give to the
                  holders  of  Series B Stock at  least 20 days'  prior  written
                  notice of the date on which any Major Change,  dissolution  or
                  liquidation will take place.

                                     (j) Mechanics of Conversion. So long as any
                  shares of Series B Stock remain  outstanding,  at the election
                  of the respective  holders thereof,  any and all shares of the
                  Series B Stock may be converted at any time on and  subsequent
                  to the second  anniversary  of the initial  issuance  and from
                  time to time into the number of fully paid and  non-assessable
                  shares of Common Stock of the Company  calculated as set forth
                  herein.  In order to exercise the  conversion  privilege,  the
                  holder of Series B Stock shall surrender the  certificates for
                  the  Series  B Stock to be  converted  at the  offices  of the
                  Company in the  Commonwealth of  Massachusetts,  together with
                  written  notice  to the  Company  that the  holder  elects  to
                  convert such Series B Stock or a portion thereof.  Such notice
                  shall also state the name or names (with address) in which the
                  certificates  for  shares of  Common  Stock  issuable  on such
                  conversion  shall be issued.  Series B Stock  surrendered  for
                  conversion shall be accompanied by proper assignments  thereof
                  to the Company or in blank for transfer  and the  signature of
                  the holder shall be guaranteed by a firm having  membership on
                  the New York Stock  Exchange or by a commercial  bank or trust
                  company  located in or having a  correspondent  in the City of
                  New York, and such conversion  shall be deemed  effective upon
                  the date of delivery of such  certificates  in accordance with
                  the provisions of this subdivision (j).

                                     (k)   Fractional   Shares;   Dividends   on
                  Conversion.  No  fractional  shares  of Common  Stock  will be
                  issuable  upon  conversion  of Series B Stock.  The Company in
                  lieu thereof, will make a payment in cash in lieu of


                                      -17-




                  any  fractional  share of Common Stock to which the converting
                  holder  would  be  entitled  if  such  fractional   share  was
                  issuable,  based  upon the  market  price of a share of Common
                  Stock as of the Conversion  Date.  Upon such  conversion,  the
                  Company will pay all then accrued, but unpaid,  dividends with
                  respect  to each  share  converted  which  have not been  paid
                  theretofore.

                           (4)      Dividends.

                                    (a) The  annual  dividend  rate at which the
                  holders of shares  shall be entitled to received  dividends is
                  $.1253 per share per annum. The holders of the shares shall be
                  entitled to receive,  out of funds legally available  therefor
                  under   Section  170  (or  its   successor)  of  the  Delaware
                  Corporation  Law,  mandatory  preferential  dividends  at such
                  annual rate payable annually on the first day of April in each
                  year.  Such dividends  shall accrue on a daily basis and shall
                  be cumulative.

                                    (b)  The  Board  of   Directors   shall  pay
                  dividends in cash or, at the Board of Directors' election,  in
                  shares of Common  Stock,  including  dividends  accrued  under
                  paragraph  (a) but unpaid on any share of Series B Stock as of
                  the date on which such share is converted  into Common  Stock.
                  If  paid  in  Common  Stock,  the  dividend  shall  be paid by
                  delivering  shares of Common Stock to, and  registered  on the
                  books of the Company in the name of, the registered  holder of
                  the share of Series B Stock on the record  date or the date of
                  conversion,  as the case may be. The number of such  shares of
                  Common  Stock so  deliverable  shall be that  number  of whole
                  shares  which,   when  multiplied  by  the  "per-share  value"
                  determined below, shall equal the total amount of the dividend
                  then due.  "Per-share  value" shall be equal to the average of
                  the last  sale  prices  of the  Common  Stock on the  National
                  Association of Securities  Dealers Automated  Quotation System
                  for the ten days  immediately  preceding such dividend payment
                  date,  or if the Common  Stock is then listed on any  national
                  securities exchange, the average of the closing prices on such
                  stock exchange during such ten days. No fractional shares will
                  be issued in  payment  of any  dividend  contemplated  by this
                  paragraph   (b).   In  lieu   thereof   there  shall  be  paid
                  simultaneously  with the  distribution  of the whole shares of
                  Common  Stock,  cash in the amount of the "per share value" of
                  any fractional share.

                                    (c) If the Company  declares a  distribution
                  upon the Common Stock, other than a distribution paid entirely
                  in Common  Stock,  payable  otherwise  than out of earnings or
                  earned  surplus   determined  in  accordance   with  generally
                  accepted  accounting   principles,   consistently  applied  (a
                  "Liquidating  Dividend"),  then the  Company  will pay to each
                  holder  of  Series  B  Stock,  at the  time  of  payment  of a
                  Liquidating  Dividend,  an amount equal to the aggregate value
                  of all Liquidating Dividends which would have been paid on the


                                      -18-




                  Common Stock issuable upon  conversion of such holder's Series
                  B Stock had such Common Stock been converted immediately prior
                  to the date on which a record  was taken for such  Liquidating
                  Dividend, or, if no record was taken, the date as of which the
                  record holders of Common Stock entitled to such dividends were
                  determined.  For  purposes  of this  paragraph  4, a dividend,
                  other than in cash,  notes,  debentures or capital stock, will
                  not be  considered  payable out of earnings or earned  surplus
                  regardless  of whether or not  earnings or earned  surplus are
                  charged an amount equal to the fair value of such dividend. No
                  distribution in respect of Series B Stock contemplated by this
                  paragraph  4(c)  shall be  deemed  to  reduce  the  amount  of
                  dividends then cumulated but unpaid under paragraph 4(a).

                                    (d)  Except  as  contemplated  by  paragraph
                  4(c), no dividend or distribution  will be declared or paid on
                  the Common Stock when any dividends  contemplated by paragraph
                  4(a) are cumulated but unpaid.

                           (5)  Preference on  Liquidation.  The  preference per
                  share which the  holders of Series B Preferred  Stock shall be
                  entitled  to receive  over the holders of each share of Common
                  Stock,  and each  share of  Preferred  Stock  (other  than the
                  shares of any other series of Preferred Stock initially issued
                  in its  entirety to American  Cyanamid  Company,  which series
                  shall rank pari passu with Series B Stock), in the case of the
                  liquidation,  distribution or sale of all or substantially all
                  of the  Company's  assets,  dissolution  or  winding up of the
                  Company, whether voluntary or involuntary, shall be $12.53 per
                  share,  plus in any such case,  an amount equal to any and all
                  dividends cumulated but unpaid.

                           (6)  Protective  Provisions.  Until the date American
                  Cyanamid Company ceases to be the registered  holder of all of
                  the issued  and  outstanding  Preferred  Stock of at least one
                  series, the Company will not, without the approval by the vote
                  or written  consent of at least a majority of the  outstanding
                  shares of all series of Preferred  Stock  initially  issued in
                  its entirety to American Cyanamid Company,  voting as a single
                  class:

                                    (a)  authorize  or issue shares of any class
                  of stock having any preference or priority,  or, unless issued
                  to American  Cyanamid  Company or its  designee,  ranking pari
                  passu, as to dividends or assets superior to any such series;

                                    (b)  reclassify  any  shares of any class of
                  stock into  shares  having any  preference  or  priority as to
                  dividends or assets, superior to any such series;

                                    (c) make any amendment to its Certificate of
                  Incorporation  or by-laws  adversely  affecting  the rights of
                  holders of any such series;

                                    
                                      -19-




                                    (d)  merge or  consolidate  with any  entity
                  (other than a  wholly-owned  subsidiary  of the  Company),  or
                  sell,   lease,   mortgage  or  otherwise  dispose  of  all  or
                  substantially  all  of its  assets,  or  liquidate,  dissolve,
                  recapitalize or reorganize;

                                    (e)  repurchase  or redeem any shares of its
                  Common Stock;

                                    (f)  pay   dividends   or  make  any   other
                  distribution  on any  shares of  Common  Stock,  other  than a
                  distribution  payable  entirely  in shares  of  Common  Stock,
                  unless,  simultaneous  with such payment or distribution,  the
                  Company pays or  distributes to each holder of Series B Stock,
                  at the time of such  payment  or  distribution,  a payment  or
                  distribution  equal in amount and paid in the same form as the
                  payment or  distribution  such holder would have  received had
                  such holder converted its shares of Series B Stock into Common
                  Stock  immediately prior to the record date for the payment or
                  distribution  to  holders  of Common  Stock.  Any  payment  or
                  distribution  pursuant to this paragraph  shall be in addition
                  to and shall not be deemed to reduce the  amount of  dividends
                  then cumulated but unpaid under paragraph 4(a); or

                                    (g) guarantee any  indebtedness of any third
                  party, except a subsidiary for borrowed money.

                           (7) Amendment. No amendment of any term of the Series
                  B Stock may be made without the affirmative vote of holders of
                  at least 2/3 of the outstanding shares of Series B Stock.

FIFTH             The Stockholders, or the Board of Directors of the Corporation
                  without the assent or vote of the stockholders, shall have the
                  power to adopt,  alter,  amend or repeal  the  By-Laws  of the
                  Corporation.

SIXTH:            No  director  of  the  Corporation  shall  be  liable  to  the
                  Corporation  or its  stockholders  for monetary  damages,  for
                  breach of fiduciary  duty as a director,  except for liability
                  (i) for any  breach of the  director's  duty of loyalty to the
                  Corporation or its stockholders,  (ii) for acts or commissions
                  not in good faith or which involve intentional misconduct or a
                  knowing  violation  of law,  (iii)  under  Section  174 of the
                  Delaware General  Corporation Law, or (iv) for any transaction
                  from which the director derived an improper personal benefit.

SEVENTH:          The Corporation  shall indemnify any person to the full extent
                  permitted  by the  Business  Corporation  Law of the  State of
                  Delaware, as the same now exists or may hereafter be amended.


                                      -20-





                  IN  WITNESS  WHEREOF,   this  Restated  Certificate  has  been
subscribed to this 11th day of February,  1993 by the  undersigned,  who affirms
that the statements made herein are true under the penalty of perjury.

                                             INTERNEURON PHARMACEUTICALS, INC.


                                             By:  /s/ Lindsay Rosenwald
                                                --------------------------
                                                 Lindsay Rosenwald, M.D.
                                                 Chairman of the Board


ATTEST:



By:  /s/ Jill Cohen
   ------------------------
   Jill Cohen, Secretary


                                      -21-






                                                                  EXHIBIT 10.65a


                        INTERNEURON PHARMACEUTICALS, INC.

                    1994 LONG-TERM INCENTIVE PLAN, AS AMENDED


1.                Purpose.

                  The  purpose  of this  plan  (the  "Plan")  is to  secure  for
INTERNEURON  PHARMACEUTICALS,  INC. (the  "Company")  and its  stockholders  the
benefits  arising  from  capital  stock  ownership  by  employees,  officers and
directors  of, and  consultants  or advisors to, the Company who are expected to
contribute to the Company's future growth and success.  Except where the context
otherwise  requires,  the term  "Company"  shall  include all present and future
subsidiaries  of the  Company as defined  in  Sections  424(e) and 424(f) of the
Internal  Revenue  Code of 1986,  as amended or replaced  from time to time (the
"Code").  Those  provisions of the Plan which make express  reference to Section
422 shall apply only to Incentive  Stock Options (as that term is defined in the
Plan).

2.                Type of Options and Administration.

                  (a) Types of  Options.  Options  granted  pursuant to the Plan
shall be  authorized  by action of the Board of  Directors  of the Company (or a
committee  designated by the Board of  Directors,  the  "Committee")  and may be
either  incentive  stock  options   ("Incentive   Stock  Options")  meeting  the
requirements of Section 422 of the Code or  non-statutory  options which are not
intended to meet the requirements of Section 422 of the Code.

                  (b) Administration. The Plan will be administered by the Board
of Directors or the Committee,  whose  construction  and  interpretation  of the
terms and provisions of the Plan shall be final and  conclusive.  The delegation
of  powers  to the  Committee  shall  be  consistent  with  applicable  laws  or
regulations (including, without limitation,  applicable state law and Rule 16b-3
("Rule  16b-3")  promulgated  under  the  Securities  Exchange  Act of 1934 (the
"Exchange Act"), or any successor rule). The Board of Directors or the Committee
may in its sole  discretion  grant  options to purchase  shares of the Company's
Common Stock,  $.001 par value per share ("Common  Stock") and issue shares upon
exercise of such options as provided in the Plan.  The Board of Directors or the
Committee shall have authority,  subject to the express  provisions of the Plan,
to construe the respective option  agreements and the Plan, to prescribe,  amend
and rescind rules and  regulations  relating to the Plan, to determine the terms
and provisions of the respective option agreements, which need not be identical,
and to make all other  determinations  in the judgment of the Board of Directors
or the Committee  necessary or desirable for the administration of the Plan. The
Board of  Directors  or the  Committee  may  correct  any  defect or supply  any
omission or reconcile any  inconsistency  in the Plan or in any option agreement
in the manner and to the extent it shall deem  expedient  to carry the Plan into
effect and it shall be the sole and final judge of such expediency.  No director
or person  acting  pursuant to authority  delegated by the Board of Directors or
the  Committee  shall be liable for any action or  determination  under the Plan
made in good faith. Subject to adjustment as









provided in Section 15 below,  the  aggregate  number of shares of Common  Stock
that may be subject to  Options  granted to any person in a calendar  year shall
not  exceed  25% of the  maximum  number of shares  which may be issued and sold
under the Plan, as set forth in Section 4 hereof, as such section may be amended
from time to time.

                  (c) Applicability of Rule 16b-3.  Those provisions of the Plan
which make  express  reference  to Rule 16b-3 shall apply to the Company only at
such time as the Company's  Common Stock is  registered  under the Exchange Act,
subject to the last sentence of Section  3(b),  and then only to such persons as
are  required  to file  reports  under  Section  16(a)  of the  Exchange  Act (a
"Reporting Person").

3.                Eligibility.

                  (a) General. Options may be granted to persons who are, at the
time of grant,  employees,  officers or directors of, or consultants or advisors
to, the Company or any subsidiaries of the Company as defined in Sections 424(e)
and 424(f) of the Code ("Participants")  provided,  that Incentive Stock Options
may only be granted to individuals  who are employees of the Company (within the
meaning of Section 3401(c) of the Code). A person who has been granted an option
may, if he or she is otherwise  eligible,  be granted  additional options if the
Board of Directors or the Committee shall so determine.

                  (b) Grant of Options to Reporting Persons.  The selection of a
director or an officer who is a Reporting  Person (as the terms  "director"  and
"officer"  are defined for  purposes of Rule 16b-3) as a recipient of an option,
the timing of the option grant,  the exercise price of the option and the number
of shares  subject to the option shall be determined  either (i) by the Board of
Directors,  (ii) by a committee  consisting of two or more directors having full
authority to act in the matter or (iii)  pursuant to  provisions  for  automatic
grants set forth in Section 3(c) below.

                  (c) Directors'  Options.  Directors of the Company who are not
employees and who are not  stockholders  of the Company  beneficially  owning in
excess  of  5% of  the  outstanding  Common  Stock  of  the  Company  ("Eligible
Directors") will receive an option ("Director Option") to purchase 20,000 shares
of Common  Stock on the date that such  person is first  elected or  appointed a
director  ("Initial  Director  Option").   Commencing  on  the  day  immediately
following  the date of the annual  meeting  of  stockholders  for the  Company's
fiscal year ending  September 30, 1996,  each Eligible  Director will receive an
automatic  grant  ("Automatic  Grant") of a Director  Option to  purchase  5,000
shares of Common Stock,  other than  Eligible  Directors who received an Initial
Director  Option since the most recent  Automatic  Grant, on the day immediately
following  the date of each  annual  meeting  of  stockholders,  as long as such
director  is a member of the Board of  Directors.  The  exercise  price for each
share  subject to a Director  Option  shall be equal to the fair market value of
the Common Stock on the date of grant. Director Options shall become exercisable
in four equal annual  installments  commencing one year from the date the option
is granted and will expire the earlier of 10 years after the date of grant or 90
days after the termination of the director's service on the Board.




                                        2





4.                Stock Subject to Plan.

                  The stock  subject to options  granted under the Plan shall be
shares of  authorized  but  unissued  or  reacquired  Common  Stock.  Subject to
adjustment  as  provided in Section 15 below,  the  maximum  number of shares of
Common  Stock of the  Company  which  may be issued  and sold  under the Plan is
6,000,000 shares. If an option granted under the Plan shall expire, terminate or
is  cancelled  for any  reason  without  having  been  exercised  in  full,  the
unpurchased  shares  subject  to  such  option  shall  again  be  available  for
subsequent option grants under the Plan.

5.                Forms of Option Agreements.

                  As a condition to the grant of an option under the Plan,  each
recipient  of an  option  shall  execute  an option  agreement  in such form not
inconsistent  with the Plan as may be approved by the Board of  Directors or the
Committee. Such option agreements may differ among recipients.

6.                Purchase Price.

                  (a) General. The purchase price per share of stock deliverable
upon the exercise of an option shall be  determined by the Board of Directors or
the Committee at the time of grant of such option;  provided,  however,  that in
the case of an Incentive Stock Option, the exercise price shall not be less than
100% of the Fair Market  Value (as  hereinafter  defined) of such stock,  at the
time of grant of such option, or less than 110% of such Fair Market Value in the
case of options  described in Section  11(b).  "Fair Market Value" of a share of
Common Stock of the Company as of a specified  date for the purposes of the Plan
shall mean the  closing  price of a share of the Common  Stock on the  principal
securities  exchange (including the Nasdaq National Market) on which such shares
are traded on the day  immediately  preceding  the date as of which Fair  Market
Value is being  determined,  or on the next  preceding date on which such shares
are traded if no shares were traded on such immediately preceding day, or if the
shares are not traded on a  securities  exchange,  Fair  Market  Value  shall be
deemed to be the  average of the high bid and low asked  prices of the shares in
the  over-the-counter  market on the day  immediately  preceding  the date as of
which Fair Market Value is being  determined  or on the next  preceding  date on
which such high bid and low asked  prices were  recorded.  If the shares are not
publicly traded, Fair Market Value of a share of Common Stock (including, in the
case of any repurchase of shares,  any distributions  with respect thereto which
would be  repurchased  with the shares) shall be determined in good faith by the
Board of  Directors  or the  Committee.  In no case shall Fair  Market  Value be
determined with regard to restrictions  other than restrictions  which, by their
terms, will never lapse.

                  (b) Payment of Purchase Price.  Options granted under the Plan
may provide for the payment of the exercise price by delivery of cash or a check
to the order of the  Company in an amount  equal to the  exercise  price of such
options,  or by any other means which the Board of  Directors  or the  Committee
determines are consistent with the purpose of the Plan and with



                                        3





applicable laws and regulations (including,  without limitation,  the provisions
of Rule 16b-3 and Regulation T promulgated by the Federal Reserve Board).

7.                Option Period.

                  Subject to earlier  termination as provided in the Plan,  each
option and all rights  thereunder shall expire on such date as determined by the
Board of  Directors  or the  Committee  and set forth in the  applicable  option
agreement, provided, that such date shall not be later than (10) ten years after
the date on which the option is granted.

8.                Exercise of Options.

                  Each option granted under the Plan shall be exercisable either
in full or in installments at such time or times and during such period as shall
be set forth in the option  agreement  evidencing  such  option,  subject to the
provisions of the Plan. Subject to the requirements in the immediately preceding
sentence, if an option is not at the time of grant immediately exercisable,  the
Board of Directors or the  Committee may (i) in the  agreement  evidencing  such
option,  provide  for the  acceleration  of the  exercise  date or  dates of the
subject option upon the occurrence of specified events,  and/or (ii) at any time
prior to the complete termination of an option,  accelerate the exercise date or
dates of such option.

9.                Transferability of Options.

                  No  incentive  stock option  granted  under this Plan shall be
assignable or otherwise  transferable  by the optionee  except by will or by the
laws of descent and distribution or pursuant to a qualified  domestic  relations
order  as  defined  in the  Code or Title I of the  Employee  Retirement  Income
Security Act, or the rules  thereunder.  The Board of Directors or the Committee
may, in its discretion,  authorize all or a portion of any non-statutory options
to be  granted to an  optionee  to be on terms  which  permit  transfer  by such
optionee  to  (i)  the  spouse,   children  or  grandchildren  of  the  optionee
("Immediate  Family Members"),  (ii) a trust or trusts for the exclusive benefit
of such Immediate Family Members, or (iii) a partnership in which such Immediate
Family Members are the only partners, provided that (w) the options must be held
by the optionee for a period of at least one month prior to transfer,  (x) there
may be no  consideration  for any such transfer,  (y) the stock option agreement
pursuant  to which such  options  are  granted  must be approved by the Board of
Directors or the Committee,  and must expressly provide for transferability in a
manner consistent with this Section, and (z) subsequent transfers of transferred
options  shall  be  prohibited  except  by  will  or the  laws  of  descent  and
distribution or pursuant to a qualified  domestic  relations order as defined in
the Code or Title I of the Employee Retirement Income Security Act, or the rules
thereunder. Following transfer, any such options shall continue to be subject to
the same terms and conditions as were applicable  immediately prior to transfer,
provided  that for purposes of the Plan the term  "optionee"  shall be deemed to
refer to the  transferee.  The events of termination of employment of Section 10
hereof shall  continue to be applied with respect to the original  optionee.  An
option may be exercised during the lifetime of the optionee only by the original
optionee. In the event an optionee dies



                                        4





during his employment by the Company or any of its  subsidiaries,  or during the
three-month  period  following the date of termination of such  employment,  his
option  shall  thereafter  be  exercisable,  during the period  specified in the
option agreement, by his executors or administrators to the full extent to which
such option was  exercisable by the optionee at the time of his death during the
periods set forth in Section 10 or 11(d).

10.               Effect of Termination of Employment or Other Relationship.

                  Except as provided in Section  11(d) with respect to Incentive
Stock Options and except as otherwise determined by the Committee at the date of
grant of an Option,  and subject to the  provisions of the Plan, an optionee may
exercise an option at any time within six (6) months  following the  termination
of the optionee's  employment or other  relationship  with the Company or within
one (1)  year if such  termination  was due to the  death or  disability  of the
optionee but, except in the case of the optionee's death, in no event later than
the  expiration  date  of the  Option.  If  the  termination  of the  optionee's
employment is for cause or is otherwise attributable to a breach by the optionee
of an employment or  confidentiality  or  non-disclosure  agreement,  the option
shall expire  immediately  upon such  termination.  The Board of Directors shall
have the power to determine what constitutes a termination for cause or a breach
of an employment or  confidentiality  or  non-disclosure  agreement,  whether an
optionee has been  terminated  for cause or has breached such an agreement,  and
the date upon  which  such  termination  for cause or  breach  occurs.  Any such
determinations shall be final and conclusive and binding upon the optionee.

11.               Incentive Stock Options.

                  Options  granted  under  the Plan  which  are  intended  to be
Incentive Stock Options shall be subject to the following  additional  terms and
conditions:

                  (a) Express  Designation.  All Incentive Stock Options granted
under the Plan shall, at the time of grant,  be specifically  designated as such
in the option agreement covering such Incentive Stock Options.

                  (b) 10%  Stockholder.  If any  employee  to whom an  Incentive
Stock  Option  is to be  granted  under the Plan is, at the time of the grant of
such option,  the owner of stock  possessing more than 10% of the total combined
voting power of all classes of stock of the Company  (after  taking into account
the attribution of stock  ownership  rules of Section 424(d) of the Code),  then
the following  special  provisions  shall be  applicable to the Incentive  Stock
Option granted to such individual:

                         (i) The  purchase  price per share of the Common  Stock
                  subject to such Incentive  Stock Option shall not be less than
                  110% of the Fair Market  Value of one share of Common Stock at
                  the time of grant; and




                                        5





                        (ii) The option  exercise  period  shall not exceed five
                  years from the date of grant.

                  (c)  Dollar  Limitation.  For so long  as the  Code  shall  so
provide, options granted to any employee under the Plan (and any other incentive
stock option plans of the Company)  which are intended to  constitute  Incentive
Stock Options shall not  constitute  Incentive  Stock Options to the extent that
such options, in the aggregate, become exercisable for the first time in any one
calendar year for shares of Common Stock with an aggregate Fair Market Value, as
of the respective date or dates of grant, of more than $100,000.

                  (d)  Termination  of  Employment,   Death  or  Disability.  No
Incentive  Stock Option may be exercised  unless,  at the time of such exercise,
the optionee is, and has been continuously since the date of grant of his or her
option, employed by the Company, except that:

                         (i) an Incentive  Stock Option may be exercised  within
                  the period of three months after the date the optionee  ceases
                  to be an employee of the Company (or within such lesser period
                  as  may be  specified  in the  applicable  option  agreement),
                  provided,  that the agreement  with respect to such option may
                  designate a longer exercise period and that the exercise after
                  such three-month  period shall be treated as the exercise of a
                  non-statutory option under the Plan;

                        (ii) if the  optionee  dies  while in the  employ of the
                  Company,  or within three months after the optionee  ceases to
                  be  such  an  employee,  the  Incentive  Stock  Option  may be
                  exercised by the person to whom it is  transferred  by will or
                  the laws of descent and distribution  within the period of one
                  year after the date of death (or within such lesser  period as
                  may be specified in the applicable option agreement); and

                       (iii)  if  the  optionee  becomes  disabled  (within  the
                  meaning  of  Section  22(e)(3)  of the  Code or any  successor
                  provisions  thereto)  while in the employ of the Company,  the
                  Incentive  Stock Option may be exercised  within the period of
                  one year  after  the date the  optionee  ceases  to be such an
                  employee  because of such  disability  (or within  such lesser
                  period  as  may  be   specified  in  the   applicable   option
                  agreement).

For all  purposes  of the Plan and any option  granted  hereunder,  "employment"
shall be defined in accordance with the provisions of Section  1.421-7(h) of the
Income Tax  Regulations  (or any  successor  regulations).  Notwithstanding  the
foregoing  provisions,  no Incentive  Stock  Option may be  exercised  after its
expiration date.

12.               Additional Provisions.

                  (a) Additional  Option  Provisions.  The Board of Directors or
the Committee  may, in its sole  discretion,  include  additional  provisions in
option agreements covering options



                                        6





granted under the Plan,  including without limitation  restrictions on transfer,
repurchase rights, rights of first refusal,  commitments to pay cash bonuses, to
make,  arrange for or guaranty  loans or to transfer other property to optionees
upon exercise of options, or such other provisions as shall be determined by the
Board of Directors or the Committee;  provided,  that such additional provisions
shall not be inconsistent  with any other term or condition of the Plan and such
additional  provisions  shall not cause any Incentive Stock Option granted under
the Plan to fail to qualify as an Incentive  Stock Option  within the meaning of
Section 422 of the Code.

                  (b)  Acceleration,  Extension,  Etc. The Board of Directors or
the Committee may, in its sole  discretion,  (i) accelerate the date or dates on
which all or any  particular  option or  options  granted  under the Plan may be
exercised or (ii) extend the dates during which all, or any  particular,  option
or options granted under the Plan may be exercised;  provided,  however, that no
such  extension  shall be permitted if it would cause the Plan to fail to comply
with Section 422 of the Code or with Rule 16b-3 (if applicable).

13.               General Restrictions.

                  (a)  Investment  Representations.  The Company may require any
optionee,  as a condition of exercising such option, to give written  assurances
in substance and form satisfactory to the Company to the effect that such person
is acquiring the Common Stock subject to the option or award, for his or her own
account  for  investment  and not with  any  present  intention  of  selling  or
otherwise  distributing the same, and to such other effects as the Company deems
necessary or appropriate  in order to comply with federal and  applicable  state
securities  laws, or with  covenants or  representations  made by the Company in
connection with any public offering of its Common Stock, including any "lock-up"
or other restriction on transferability.

                  (b)  Compliance  With  Securities  Law.  Each Option  shall be
subject to the  requirement  that if, at any time,  counsel to the Company shall
determine that the listing,  registration or qualification of the shares subject
to such  option or award upon any  securities  exchange or  automated  quotation
system or under any state or federal  law,  or the  consent or  approval  of any
governmental   or  regulatory   body,  or  that  the  disclosure  of  non-public
information  or the  satisfaction  of any  other  condition  is  necessary  as a
condition  of, or in  connection  with the issuance of shares  thereunder,  such
option  may  not be  exercised,  in  whole  or in  part,  unless  such  listing,
registration,  qualification,  consent  or  approval,  or  satisfaction  of such
condition  shall have been effected or obtained on conditions  acceptable to the
Board of  Directors.  Nothing  herein  shall be deemed to require the Company to
apply  for or to obtain  such  listing,  registration  or  qualification,  or to
satisfy such condition.

14.               Rights as a Stockholder.

                  The holder of an option shall have no rights as a  stockholder
with respect to any shares covered by the option (including, without limitation,
any rights to receive dividends or non-cash  distributions  with respect to such
shares) until the date of issue of a stock certificate to



                                        7





him or her for such shares.  No adjustment  shall be made for dividends or other
rights for which the record date is prior to the date such stock  certificate is
issued.

15.               Adjustment Provisions for  Recapitalizations,  Reorganizations
                  and Related Transactions.

                  (a) Recapitalizations and Related Transactions. If, through or
as a result of any  recapitalization,  reclassification,  stock dividend,  stock
split,  reverse stock split or other similar  transaction,  (i) the  outstanding
shares of Common Stock are  increased,  decreased  or exchanged  for a different
number or kind of shares or other securities of the Company,  or (ii) additional
shares or new or different  shares or other non-cash assets are distributed with
respect to such shares of Common Stock or other  securities,  an appropriate and
proportionate  adjustment  shall be made in (x) the  maximum  number and kind of
shares reserved for issuance under or otherwise referred to in the Plan, (y) the
number and kind of shares or other  securities  subject to any then  outstanding
options  under the Plan,  and (z) the price for each  share  subject to any then
outstanding  options under the Plan,  without  changing the  aggregate  purchase
price  as  to  which  such  options  remain  exercisable.   Notwithstanding  the
foregoing,  no  adjustment  shall be made  pursuant  to this  Section 15 if such
adjustment  (i) would cause the Plan to fail to comply  with  Section 422 of the
Code or with Rule 16b-3 or (ii) would be  considered  as the  adoption  of a new
plan requiring stockholder approval.

                  (b)  Reorganization,  Merger  and  Related  Transactions.  All
outstanding  Options under the Plan shall become fully  exercisable for a period
of sixty (60) days following the occurrence of any Trigger Event, whether or not
such  Options  are then  exercisable  under  the  provisions  of the  applicable
agreements relating thereto.  For purposes of the Plan, a "Trigger Event" is any
one of the following events:

                           (i) the date on which  shares  of  Common  Stock  are
         first  purchased  pursuant to a tender  offer or exchange  offer (other
         than such an offer by the Company, any Subsidiary, any employee benefit
         plan of the Company or of any  Subsidiary or any entity  holding shares
         or other securities of the Company for or pursuant to the terms of such
         plan),  whether or not such offer is approved or opposed by the Company
         and  regardless  of the  number of shares  purchased  pursuant  to such
         offer;

                           (ii) the date the Company acquires knowledge that any
         person or group deemed a person under  Section  13(d)-3 of the Exchange
         Act (other than the Company, any Subsidiary,  any employee benefit plan
         of the Company or of any  Subsidiary  or any entity  holding  shares of
         Common Stock or other  securities of the Company for or pursuant to the
         terms  of any  such  plan or any  individual  or  entity  or  group  or
         affiliate  thereof which  acquired its  beneficial  ownership  interest
         prior to the date the Plan was adopted by the Board),  in a transaction
         or series of transactions, has become the beneficial owner, directly or
         indirectly  (with beneficial  ownership  determined as provided in Rule
         13d-3, or any successor rule, under the Exchange Act), of securities of
         the Company entitling the person or group to 30% or more of all votes



                                        8





         (without  consideration  of the  rights  of any class or stock to elect
         directors by a separate  class vote) to which all  shareholders  of the
         Company  would be  entitled in the  election of the Board of  Directors
         were an election held on such date;

                           (iii) the date,  during any period of two consecutive
         years,  when individuals who at the beginning of such period constitute
         the  Board  of  Directors  of the  Company  cease  for  any  reason  to
         constitute at least a majority  thereof,  unless the  election,  or the
         nomination for election by the stockholders of the Company, of each new
         director was approved by a vote of at least two-thirds of the directors
         then  still in  office  who were  directors  at the  beginning  of such
         period; and

                           (iv) the date of approval by the  stockholders of the
         Company of an agreement (a "reorganization agreement") providing for:

                                    (A)  The  merger  or  consolidation  of  the
                  Company with another corporation where the stockholders of the
                  Company, immediately prior to the merger or consolidation,  do
                  not  beneficially   own,   immediately  after  the  merger  or
                  consolidation,  shares  of the  corporation  issuing  cash  or
                  securities  in the  merger  or  consolidation  entitling  such
                  stockholders   to  65%  or   more   of  all   votes   (without
                  consideration  of the  rights  of any  class of stock to elect
                  directors by a separate class vote) to which all  shareholders
                  of such  corporation  would be  entitled  in the  election  of
                  directors  or where the members of the Board of  Directors  of
                  the Company, immediately prior to the merger or consolidation,
                  do  not,   immediately  after  the  merger  or  consolidation,
                  constitute  a  majority  of  the  Board  of  Directors  of the
                  corporation  issuing  cash  or  securities  in the  merger  or
                  consolidation; or

                                    (B) The sale or other  disposition of all or
                  substantially all the assets of the Company.

                  (c) Board Authority to Make Adjustments. Any adjustments under
this Section 15 will be made by the Board of Directors,  whose  determination as
to what adjustments,  if any, will be made and the extent thereof will be final,
binding and  conclusive.  No fractional  shares will be issued under the Plan on
account of any such adjustments.

16.               Merger, Consolidation, Asset Sale, Liquidation, etc.

                  (a) General. In the event of a consolidation or merger or sale
of all or  substantially  all of the assets of the Company in which  outstanding
shares of Common Stock are exchanged for  securities,  cash or other property of
any other corporation or business entity or in the event of a liquidation of the
Company, the Board of Directors of the Company, or the board of directors of any
corporation  assuming the  obligations of the Company,  may, in its  discretion,
take any one or more of the following actions, as to outstanding options: (i) in
the event of a merger  under the terms of which  holders of the Common  Stock of
the Company will receive upon consummation thereof a cash payment for each share
surrendered in the merger (the



                                        9





"Merger  Price"),  make or provide for a cash payment to the optionees  equal to
the difference between (A) the Merger Price times the number of shares of Common
Stock subject to such  outstanding  options (to the extent then  exercisable  at
prices not in excess of the Merger Price) and (B) the aggregate  exercise  price
of all such outstanding options in exchange for the termination of such options,
and (ii) in the event the provisions of Section 15 are not  applicable,  provide
that all or any outstanding options shall become exercisable in full immediately
prior to such event and upon written notice to the  optionees,  provide that all
unexercised options will terminate immediately prior to the consummation of such
transaction unless exercised by the optionee within a specified period following
the date of such notice.

                  (b)  Substitute  Options.  The Company may grant options under
the Plan in  substitution  for options held by employees of another  corporation
who become  employees of the Company,  or a  subsidiary  of the Company,  as the
result  of a merger  or  consolidation  of the  employing  corporation  with the
Company or a subsidiary of the Company, or as a result of the acquisition by the
Company,  or one of its  subsidiaries,  of  property  or stock of the  employing
corporation.  The Company may direct that substitute  options be granted on such
terms and  conditions  as the Board of Directors  considers  appropriate  in the
circumstances.

17.               No Special Employment Rights.

                  Nothing  contained  in the Plan or in any option  shall confer
upon any  optionee  any right  with  respect to the  continuation  of his or her
employment  by the Company or interfere in any way with the right of the Company
at any  time to  terminate  such  employment  or to  increase  or  decrease  the
compensation of the optionee.

18.               Other Employee Benefits.

                  Except as to plans which by their terms  include  such amounts
as  compensation,  the amount of any  compensation  deemed to be  received by an
employee as a result of the exercise of an option or the sale of shares received
upon such exercise will not  constitute  compensation  with respect to which any
other  employee  benefits of such employee are  determined,  including,  without
limitation, benefits under any bonus, pension, profit-sharing, life insurance or
salary  continuation  plan, except as otherwise  specifically  determined by the
Board of Directors.

19.               Amendment of the Plan.

                  (a) The Board of Directors  may at any time,  and from time to
time, modify or amend the Plan in any respect; provided, however, that if at any
time the approval of the  stockholders  of the Company is required under Section
422 of the Code or any  successor  provision  with  respect to  Incentive  Stock
Options,  or under  Rule  16b-3,  the Board of  Directors  may not  effect  such
modification or amendment without such approval; and provided, further, that the
provisions  of Section 3(c) hereof shall not be amended more than once every six
months,



                                       10





other than to comport with changes in the Code, the Employer  Retirement  Income
Security Act of 1974, as amended, or the rules thereunder.

                  (b) The  modification  or  amendment  of the Plan  shall  not,
without the  consent of an  optionee,  affect his or her rights  under an option
previously granted to him or her. With the consent of the optionee affected, the
Board of  Directors  may amend  outstanding  option  agreements  in a manner not
inconsistent with the Plan. The Board of Directors shall have the right to amend
or  modify  (i) the  terms  and  provisions  of the Plan and of any  outstanding
Incentive  Stock  Options  granted  under the Plan to the  extent  necessary  to
qualify any or all such options for such favorable  federal income tax treatment
(including  deferral of taxation  upon  exercise)  as may be afforded  incentive
stock options under Section 422 of the Code and (ii) the terms and provisions of
the Plan and of any  outstanding  option to the extent  necessary  to ensure the
qualification of the Plan under Rule 16b-3.

20.               Withholding.

                  (a) The Company  shall have the right to deduct from  payments
of any kind  otherwise due to the optionee any federal,  state or local taxes of
any kind  required by law to be withheld  with respect to any shares issued upon
exercise  of  options  under the Plan.  Subject  to the  prior  approval  of the
Company,  which may be  withheld  by the  Company  in its sole  discretion,  the
optionee  may elect to satisfy  such  obligations,  in whole or in part,  (i) by
causing  the  Company to  withhold  shares of Common  Stock  otherwise  issuable
pursuant  to the  exercise  of an option or (ii) by  delivering  to the  Company
shares of Common Stock already owned by the optionee. The shares so delivered or
withheld shall have a Fair Market Value equal to such withholding  obligation as
of the date  that the  amount  of tax to be  withheld  is to be  determined.  An
optionee  who has made an  election  pursuant  to this  Section  20(a)  may only
satisfy his or her withholding  obligation with shares of Common Stock which are
not subject to any repurchase,  forfeiture, unfulfilled vesting or other similar
requirements.

                  (b) The  acceptance of shares of Common Stock upon exercise of
an Incentive  Stock Option shall  constitute an agreement by the optionee (i) to
notify the Company if any or all of such shares are  disposed of by the optionee
within two years  from the date the  option was  granted or within one year from
the date the shares were issued to the optionee  pursuant to the exercise of the
option, and (ii) if required by law, to remit to the Company, at the time of and
in the case of any  such  disposition,  an  amount  sufficient  to  satisfy  the
Company's  federal,  state and local withholding tax obligations with respect to
such  disposition,  whether or not, as to both (i) and (ii),  the optionee is in
the employ of the Company at the time of such disposition.

                  (c) Notwithstanding the foregoing,  in the case of a Reporting
Person whose  options have been granted in  accordance  with the  provisions  of
Section  3(b) herein,  no election to use shares for the payment of  withholding
taxes  shall  be  effective  unless  made  in  compliance  with  any  applicable
requirements of Rule 16b-3.




                                       11





21.               Cancellation and New Grant of Options, Etc.

                  The Board of Directors shall have the authority to effect,  at
any time and from time to time, with the consent of the affected optionees,  (i)
the cancellation of any or all outstanding  options under the Plan and the grant
in  substitution  therefor of new options  under the Plan  covering  the same or
different  numbers of shares of Common Stock and having an option exercise price
per share which may be lower or higher than the exercise  price per share of the
cancelled  options or (ii) the amendment of the terms of any and all outstanding
options  under the Plan to provide an option  exercise  price per share which is
higher  or  lower  than  the  then-current  exercise  price  per  share  of such
outstanding options.

22.               Effective Date and Duration of the Plan.

                  (a)  Effective  Date.  The Plan shall  become  effective  when
adopted by the Board of Directors,  but no Incentive  Stock Option granted under
the Plan  shall  become  exercisable  unless  and until the Plan shall have been
approved by the  Company's  stockholders.  If such  stockholder  approval is not
obtained  within  twelve  months  after the date of the Board's  adoption of the
Plan,  no  options  previously  granted  under  the Plan  shall be  deemed to be
Incentive  Stock  Options  and no  Incentive  Stock  Options  shall  be  granted
thereafter.  Amendments to the Plan not  requiring  stockholder  approval  shall
become  effective when adopted by the Board of Directors;  amendments  requiring
stockholder  approval (as provided in Section 21) shall  become  effective  when
adopted by the Board of Directors,  but no Incentive  Stock Option granted after
the date of such  amendment  shall become  exercisable  (to the extent that such
amendment to the Plan was required to enable the Company to grant such Incentive
Stock Option to a particular  optionee)  unless and until such  amendment  shall
have been approved by the Company's  stockholders.  If such stockholder approval
is not obtained within twelve months of the Board's  adoption of such amendment,
any Incentive Stock Options granted on or after the date of such amendment shall
terminate  to the extent that such  amendment to the Plan was required to enable
the  Company  to grant such  option to a  particular  optionee.  Subject to this
limitation,  options  may be  granted  under  the  Plan at any  time  after  the
effective date and before the date fixed for termination of the Plan.

                  (b) Termination.  Unless sooner  terminated in accordance with
Section  16,  the Plan  shall  terminate  upon the  earlier  of (i) the close of
business  on the day next  preceding  the tenth  anniversary  of the date of its
adoption  by the  Board of  Directors,  or (ii) the  date on  which  all  shares
available  for  issuance  under the Plan shall have been issued  pursuant to the
exercise  or  cancellation  of options  granted  under the Plan.  If the date of
termination is determined under (i) above, then options outstanding on such date
shall continue to have force and effect in accordance with the provisions of the
instruments evidencing such options.

23.               Provision for Foreign Participants.

                  The Board of Directors may, without amending the Plan,  modify
awards or options granted to participants who are foreign  nationals or employed
outside the United States to recognize  differences in laws, rules,  regulations
or customs  of such  foreign  jurisdictions  with  respect  to tax,  securities,
currency, employee benefit or other matters.



                                       12




24.               Governing Law.

                  The provisions of this Plan shall be governed and construed in
accordance  with  the  laws of the  State  of  Delaware  without  regard  to the
principles of conflicts of laws.

                  Adopted  by the Board of  Directors  on  September  23,  1994;
amended by the Board of Directors December 18, 1996.





                                       13



                                                                   EXHIBIT 10.89



(MULTICURRENCY--CROSS BORDER)

                                     ISDA(R)
                  International Swap Dealers Association, Inc.

                                MASTER AGREEMENT

                             dated as of May 5, 1997

Swiss   Bank   Corporation,   London   Branch   ("Party   A")  and   Interneuron
Pharmaceuticals,  Inc. ("Party B") have entered and/or anticipate  entering into
one or more transactions (each a "Transaction")  that are or will be governed by
this Master  Agreement,  which includes the schedule (the  "Schedule"),  and the
documents  and  other  confirming  evidence  (each a  "Confirmation")  exchanged
between the parties confirming those Transactions.

Accordingly, the parties agree as follows:--

1.       INTERPRETATION

(a)  DEFINITIONS.  The terms defined in Section 14 and in the Schedule will have
the meanings therein specified for the purpose of this Master Agreement.

(b) INCONSISTENCY.  In the event of any inconsistency  between the provisions of
the Schedule and the other  provisions  of this Master  Agreement,  the Schedule
will prevail.  In the event of any  inconsistency  between the provisions of any
Confirmation   and  this  Master  Agreement   (including  the  Schedule),   such
Confirmation will prevail for the purpose of the relevant Transaction.







(c) SINGLE AGREEMENT.  All Transactions are entered into in reliance on the fact
that this Master Agreement and all Confirmations form a single agreement between
the  parties  (collectively  referred to as this  "Agreement"),  and the parties
would not otherwise enter into any Transactions.

2.         OBLIGATIONS

(a)      GENERAL CONDITIONS.

           (i) Each party will make each  payment or delivery  specified in each
           Confirmation  to be made by it,  subject to the other  provisions  of
           this Agreement.

           (ii) Payments  under this  Agreement will be made on the due date for
           value on that  date in the  place  of the  account  specified  in the
           relevant  Confirmation or otherwise  pursuant to this  Agreement,  in
           freely transferable funds and in the manner customary for payments in
           the required  currency.  Where  settlement  is by delivery  (that is,
           other than by payment), such delivery will be made for receipt on the
           due date in the manner customary for the relevant  obligation  unless
           otherwise specified in the relevant Confirmation or elsewhere in this
           Agreement.

           (iii) Each  obligation of each party under Section 2(a)(i) is subject
           to (1) the condition  precedent that no Event of Default or Potential
           Event of Default  with respect to the other party has occurred and is
           continuing,  (2) the condition  precedent  that no Early  Termination
           Date in respect of the  relevant  Transaction  has  occurred  or been
           effectively  designated  and  (3)  each  other  applicable  condition
           precedent specified in this Agreement.

(b) CHANGE OF  ACCOUNT.  Either  party may change its  account  for  receiving a
payment  or  delivery  by giving  notice to the other  party at least five Local
Business Days prior to the  scheduled  date for the payment or delivery to which
such change  applies unless such other party gives timely notice of a reasonable
objection to such change.

(c)      NETTING.  If on any date amounts would otherwise be payable:--

           (i)   in the same currency; and

                                        2





           (ii)  in respect of the same Transaction,

by each party to the other,  then, on such date, each party's obligation to make
payment of any such amount will be  automatically  satisfied and discharged and,
if the  aggregate  amount that would  otherwise  have been  payable by one party
exceeds the aggregate amount that would otherwise have been payable by the other
party,  replaced by an  obligation  upon the party by whom the larger  aggregate
amount  would  have been  payable  to pay to the other  party the  excess of the
larger aggregate amount over the smaller aggregate amount.

The parties may elect in respect of two or more  Transactions  that a net amount
will be  determined  in respect of all  amounts  payable on the same date in the
same  currency  in  respect of such  Transactions,  regardless  of whether  such
amounts are payable in respect of the same Transaction. The election may be made
in the Schedule or a Confirmation  by specifying  that  subparagraph  (ii) above
will not apply to the Transactions  identified as being subject to the election,
together with the starting date (in which case subparagraph (ii) above will not,
or will cease to, apply to such  Transactions from such date). This election may
be  made  separately  for  different  groups  of  Transactions  and  will  apply
separately to each pairing of Offices through which the parties make and receive
payments or deliveries.

(d)      DEDUCTION OR WITHHOLDING FOR TAX.

           (i) GROSS-UP.  All payments under this Agreement will be made without
           any deduction or withholding for or on account of any Tax unless such
           deduction  or  withholding  is  required  by any  applicable  law, as
           modified  by  the  practice  of  any  relevant  governmental  revenue
           authority,  then in effect.  If a party is so  required  to deduct or
           withhold, then that party ("X") will:--

                      (1)  promptly   notify  the  other  party  ("Y")  of  such
                      requirement;

                      (2)  pay to  the  relevant  authorities  the  full  amount
                      required to be deducted  or withheld  (including  the full
                      amount  required  to be  deducted  or  withheld  from  any
                      additional  amount paid by X to Y under this Section 2(d))
                      promptly  upon  the  earlier  of  determining   that  such
                      deduction or withholding  is required or receiving  notice
                      that such amount has been assessed against Y;

                                        3





                      (3)  promptly  forward  to Y an  official  receipt  (or  a
                      certified   copy),  or  other   documentation   reasonably
                      acceptable   to  Y,   evidencing   such  payment  to  such
                      authorities; and

                      (4) if  such  Tax is an  Indemnifiable  Tax,  pay to Y, in
                      addition to the payment to which Y is  otherwise  entitled
                      under  this  Agreement,   such  additional  amount  as  is
                      necessary to ensure that the net amount actually  received
                      by Y (free  and  clear  of  Indemnifiable  Taxes,  whether
                      assessed  against  X or Y) will  equal  the full  amount Y
                      would have received had no such  deduction or  withholding
                      been required.  However, X will not be required to pay any
                      additional  amount to Y to the extent that it would not be
                      required to be paid but for:--

                                 (A) the  failure by Y to comply with or perform
                                 any  agreement  contained  in Section  4(a)(i),
                                 4(a)(iii) or 4(d); or

                                 (B) the failure of a  representation  made by Y
                                 pursuant  to Section  3(f) to be  accurate  and
                                 true  unless  such   failure   would  not  have
                                 occurred  but  for (I) any  action  taken  by a
                                 taxing  authority,  or  brought  in a court  of
                                 competent jurisdiction, on or after the date on
                                 which a Transaction is entered into (regardless
                                 of whether such action is taken or brought with
                                 respect to a party to this Agreement) or (II) a
                                 Change in Tax Law.

           (ii)  LIABILITY.  If:--

                      (1) X is  required by any  applicable  law, as modified by
                      the   practice  of  any  relevant   governmental   revenue
                      authority, to make any deduction or withholding in respect
                      of  which X would  not be  required  to pay an  additional
                      amount to Y under Section 2(d)(i)(4);

                      (2) X does not so deduct or withhold; and

                      (3) a  liability  resulting  from  such  Tax  is  assessed
                      directly against X,

           then,  except to the extent Y has  satisfied  or then  satisfies  the
           liability  resulting  from such  Tax,  Y will  promptly  pay to X the
           amount  of  such  liability  (including  any  related  liability  for
           interest, but including any related liability

                                        4






           for  penalties  only if Y has failed to comply  with or  perform  any
agreement contained in Section 4(a)(i), 4(a)(iii) or 4(d)).

(e) DEFAULT  INTEREST;  OTHER  AMOUNTS.  Prior to the  occurrence  or  effective
designation of an Early Termination Date in respect of the relevant Transaction,
a party that defaults in the performance of any payment  obligation will, to the
extent permitted by law and subject to Section 6(c), be required to pay interest
(before as well as after  judgment) on the overdue  amount to the other party on
demand in the same  currency as such  overdue  amount,  for the period from (and
including)  the  original  due date for payment to (but  excluding)  the date of
actual  payment,  at the Default  Rate.  Such interest will be calculated on the
basis of daily  compounding and the actual number of days elapsed.  If, prior to
the occurrence or effective  designation of an Early Termination Date in respect
of  the  relevant  Transaction,  a  party  defaults  in the  performance  of any
obligation  required to be settled by  delivery,  it will  compensate  the other
party on demand if and to the extent  provided for in the relevant  Confirmation
or elsewhere in this Agreement.

3.         REPRESENTATIONS


Each party represents to the other party (which  representations  will be deemed
to be repeated by each party on each date on which a Transaction is entered into
and, in the case of the  representations in Section 3(f), at all times until the
termination of this Agreement) that:--

(a)      BASIC REPRESENTATIONS.

           (i) STATUS.  It is duly organised and validly existing under the laws
           of the  jurisdiction  of its  organisation or  incorporation,  and if
           relevant under such laws, in good standing;

           (ii) POWERS. It has the power to execute this Agreement and any other
           documentation  relating to this Agreement to which it is a party,  to
           deliver this Agreement and any other  documentation  relating to this
           Agreement  that it is  required by this  Agreement  to deliver and to
           perform its  obligations  under this Agreement and any obligations it
           has under any Credit Support  Document to which it is a party and has
           taken all necessary action to authorize such execution,  delivery and
           performance;

                                        5





           (iii)  NO  VIOLATION  OR  CONFLICT.  Such  execution,   delivery  and
           performance do not violate or conflict with any law applicable to it,
           any provision of its constitutional  documents, any order or judgment
           of any court or other agency of government applicable to it or any of
           its assets or any contractual  restriction binding on or affecting it
           or any of its assets;

           (iv) CONSENTS.  All governmental and other consents that are required
           to have been  obtained by it with  respect to this  Agreement  or any
           Credit Support Document to which it is a party have been obtained and
           are in full force and effect and all  conditions of any such consents
           have been complied with; and

           (v) OBLIGATIONS BINDING. Its obligations under this Agreement and any
           Credit Support  Document to which it is a party constitute its legal,
           valid and binding  obligations,  enforceable in accordance with their
           respective terms (subject to applicable  bankruptcy,  reorganisation,
           insolvency,  moratorium or similar laws affecting  creditors'  rights
           generally and subject, as to enforceability,  to equitable principles
           of general  application  (regardless of whether enforcement is sought
           in a proceeding in equity or at law)).

(b) ABSENCE OF CERTAIN EVENTS. No Event of Default or Potential Event of Default
or, to its knowledge,  Termination  Event with respect to it has occurred and is
continuing  and no such  event or  circumstance  would  occur as a result of its
entering into or performing its  obligations  under this Agreement or any Credit
Support Document to which it is a party.

(c) ABSENCE OF LITIGATION. There is not pending or, to its knowledge, threatened
against it or any of its Affiliates any action,  suit or proceeding at law or in
equity or before any court,  tribunal,  governmental body, agency or official or
any arbitrator that is likely to affect the legality, validity or enforceability
against it of this  Agreement  or any Credit  Support  Document to which it is a
party or its ability to perform its  obligations  under this  Agreement  or such
Credit Support Document.

(d)  ACCURACY OF  SPECIFIED  INFORMATION.  All  applicable  information  that is
furnished in writing by or on behalf of it to the other party and is  identified
for the purpose of this  Section  3(d) in the Schedule is, as of the date of the
information, true, accurate and complete in every material respect.

(e) PAYER TAX REPRESENTATION.  Each representation  specified in the Schedule as
being made by it for the purpose of this Section 3(e) is accurate and true.

                                        6






(f) PAYEE TAX REPRESENTATIONS.  Each representation specified in the Schedule as
being made by it for the purpose of this Section 3(f) is accurate and true.

4.         AGREEMENTS


Each party  agrees with the other that,  so long as either party has or may have
any  obligation  under this  Agreement or under any Credit  Support  Document to
which it is a party:--

(a) FURNISH  SPECIFIED  INFORMATION.  It will  deliver to the other party or, in
certain  cases under  subparagraph  (iii) below,  to such  government  or taxing
authority as the other party reasonably directs:--

           (i)  any  forms,  documents  or  certificates  relating  to  taxation
           specified in the Schedule or any Confirmation;

           (ii)  any  other   documents   specified   in  the  Schedule  or  any
           Confirmation; and

           (iii)  upon  reasonable  demand  by such  other  party,  any  form or
           document that may be required or  reasonably  requested in writing in
           order to allow such other  party or its Credit  Support  Provider  to
           make a payment under this Agreement or any applicable  Credit Support
           Document  without any deduction or  withholding  for or on account of
           any Tax or with such  deduction or  withholding at a reduced rate (so
           long as the  completion,  execution  or  submission  of such  form or
           document  would not  materially  prejudice  the  legal or  commercial
           position of the party in receipt of such demand),  with any such form
           or document  to be  accurate  and  completed  in a manner  reasonably
           satisfactory  to  such  other  party  and  to be  executed  and to be
           delivered with any reasonably required certification,

in each case by the date specified in the Schedule or such  Confirmation  or, if
none is specified, as soon as reasonably practicable.

(b) MAINTAIN  AUTHORISATIONS.  It will use all reasonable efforts to maintain in
full force and effect all consents of any  governmental  or other authority that
are required to be obtained by it with  respect to this  Agreement or any Credit
Support Document

                                        7




to which it is a party and will use all  reasonable  efforts  to obtain any that
may become necessary in the future.

(c)  COMPLY  WITH  LAWS.  It will  comply  in all  material  respects  with  all
applicable  laws and  orders to which it may be  subject if failure so to comply
would  materially  impair  its  ability to perform  its  obligations  under this
Agreement or any Credit Support Document to which it is a party.

(d) TAX AGREEMENT.  It will give notice of any failure of a representation  made
by it under  Section 3(f) to be accurate and true promptly upon learning of such
failure.

(e)  PAYMENT  OF STAMP TAX.  Subject  to  Section  11, it will pay any Stamp Tax
levied or imposed upon it or in respect of its execution or  performance of this
Agreement by a jurisdiction in which it is incorporated,  organised, managed and
controlled,  or  considered  to have its  seat,  or in which a branch  or office
through which it is acting for the purpose of this Agreement is located  ("Stamp
Tax  Jurisdiction")  and will  indemnify  the other party  against any Stamp Tax
levied  or  imposed  upon the other  party or in  respect  of the other  party's
execution or performance  of this  Agreement by any such Stamp Tax  Jurisdiction
which is not also a Stamp Tax Jurisdiction with respect to the other party.

5.         EVENTS OF DEFAULT AND TERMINATION EVENTS

(a) EVENTS OF DEFAULT. The occurrence at any time with respect to a party or, if
applicable, any Credit Support Provider of such party or any Specified Entity of
such party of any of the following  events  constitutes  an event of default (an
"Event of Default") with respect to such party:--

           (i)  FAILURE TO PAY OR  DELIVER.  Failure by the party to make,  when
           due,  any payment  under this  Agreement  or delivery  under  Section
           2(a)(i)  or 2(e)  required  to be made by it if such  failure  is not
           remedied on or before the third Local  Business  Day after  notice of
           such failure is given to the party;

           (ii)  BREACH OF  AGREEMENT.  Failure  by the party to comply  with or
           perform any agreement or obligation (other than an obligation to make
           any payment under this Agreement or delivery under Section 2(a)(i) or
           2(e) or to give notice of a  Termination  Event or any  agreement  or
           obligation  under Section  4(a)(i),  4(a)(iii) or 4(d) to be complied
           with or performed by the party in accordance

                                        8





           with this  Agreement if such failure is not remedied on or before the
           thirtieth day after notice of such failure is given to the party;

           (iii)  CREDIT SUPPORT DEFAULT.

                      (1) Failure by the party or any Credit Support Provider of
                      such party to comply  with or  perform  any  agreement  or
                      obligation  to be  complied  with  or  performed  by it in
                      accordance  with  any  Credit  Support  Document  if  such
                      failure is continuing  after any  applicable  grace period
                      has elapsed;

                      (2) the  expiration or  termination of such Credit Support
                      Document or the failing or ceasing of such Credit  Support
                      Document to be in full force and effect for the purpose of
                      this  Agreement  (in either case other than in  accordance
                      with  its  terms)  prior  to  the   satisfaction   of  all
                      obligations of such party under each  Transaction to which
                      such Credit Support  Document  relates without the written
                      consent of the other party; or

                      (3) the party or such Credit Support Provider  disaffirms,
                      disclaims,  repudiates or rejects, in whole or in part, or
                      challenges the validity of, such Credit Support Document;

           (iv) MISREPRESENTATION. A representation (other than a representation
           under  Section  3(e) or (f)) made or  repeated or deemed to have been
           made or repeated by the party or any Credit Support  Provider of such
           party in this Agreement or any Credit Support Document proves to have
           been  incorrect or  misleading  in any material  respect when made or
           repeated or deemed to have been made or repeated;

           (v)  DEFAULT  UNDER  SPECIFIED  TRANSACTION.  The  party,  any Credit
           Support Provider of such party or any applicable  Specified Entity of
           such party (1)  defaults  under a Specified  Transaction  and,  after
           giving effect to any applicable  notice  requirement or grace period,
           there occurs a liquidation of, an acceleration of obligations  under,
           or  any  early  termination  of,  that  Specified  Transaction,   (2)
           defaults, after giving effect to any applicable notice requirement or
           grace  period,  in making  any  payment or  delivery  due on the last
           payment,  delivery  or  exchange  date of,  or any  payment  on early
           termination of, a Specified  Transaction  (or such default  continues
           for at least

                                        9





           three  Local   Business  Days  if  there  is  no  applicable   notice
           requirement or grace period) or (3) disaffirms, disclaims, repudiates
           or rejects,  in whole or in part,  a Specified  Transaction  (or such
           action is taken by any person or entity  appointed  or  empowered  to
           operate it or act on its behalf);

           (vi) CROSS DEFAULT.  If "Cross  Default" is specified in the Schedule
           as  applying  to the party,  the  occurrence  or  existence  of (1) a
           default,  event  of  default  or  other  similar  condition  or event
           (however  described)  in respect of such  party,  any Credit  Support
           Provider  of such party or any  applicable  Specified  Entity of such
           party  under  one or  more  agreements  or  instruments  relating  to
           Specified  Indebtedness of any of them (individually or collectively)
           in an  aggregate  amount  of not less than the  applicable  Threshold
           Amount (as  specified  in the  Schedule)  which has  resulted in such
           Specified  Indebtedness becoming, or becoming capable at such time of
           being declared, due and payable under such agreements or instruments,
           before it would  otherwise have been due and payable or (2) a default
           by such party,  such Credit Support Provider or such Specified Entity
           (individually  or collectively) in making one or more payments on the
           due  date  thereof  in an  aggregate  amount  of not  less  than  the
           applicable  Threshold  Amount under such  agreements  or  instruments
           (after giving effect to any  applicable  notice  requirement or grace
           period);

           (vii)  BANKRUPTCY.  The party,  any Credit  Support  Provider of such
           party or any applicable Specified Entity of such party:- -

                      (1) is dissolved  (other than pursuant to a consolidation,
                      amalgamation  or  merger);  (2)  becomes  insolvent  or is
                      unable to pay its debts or fails or admits in writing  its
                      inability  generally  to pay its debts as they become due;
                      (3) makes a general assignment, arrangement or composition
                      with or for the benefit of its  creditors;  (4) institutes
                      or  has  instituted  against  it a  proceeding  seeking  a
                      judgment of  insolvency  or bankruptcy or any other relief
                      under any  bankruptcy or  insolvency  law or other similar
                      law  affecting   creditors'   rights,  or  a  petition  is
                      presented for its winding-up or  liquidation,  and, in the
                      case of any such  proceeding  or  petition  instituted  or
                      presented  against it,  such  proceeding  or petition  (A)
                      results in a judgment of  insolvency  or bankruptcy or the
                      entry of an order for relief or the making of an order for
                      its  winding-up or  liquidation  or (B) is not  dismissed,
                      discharged,  stayed or  restrained  in each case within 30
                      days of the institution or presentation thereof; (5) has a
                      resolution passed for its winding-up, official

                                       10




                      management  or  liquidation  (other  than  pursuant  to  a
                      consolidation,  amalgamation  or  merger);  (6)  seeks  or
                      becomes  subject to the  appointment of an  administrator,
                      provisional liquidator,  conservator,  receiver,  trustee,
                      custodian or other  similar  official for it or for all or
                      substantially all its assets; (7) has a secured party take
                      possession of all or substantially all its assets or has a
                      distress,  execution,  attachment,  sequestration or other
                      legal process  levied,  enforced or sued on or against all
                      or  substantially  all its assets and such  secured  party
                      maintains   possession,   or  any  such   process  is  not
                      dismissed,  discharged, stayed or restrained, in each case
                      within 30 days thereafter; (8) causes or is subject to any
                      event with respect to it which,  under the applicable laws
                      of any jurisdiction, has an analogous effect to any of the
                      events specified in clauses (1) to (7) (inclusive); or (9)
                      takes any  action in  furtherance  of, or  indicating  its
                      consent to,  approval of, or  acquiescence  in, any of the
                      foregoing acts; or

           (viii) MERGER  WITHOUT  ASSUMPTION.  The party or any Credit  Support
           Provider of such party  consolidates  or amalgamates  with, or merges
           with or into,  or transfers all or  substantially  all its assets to,
           another entity and, at the time of such consolidation,  amalgamation,
           merger or transfer:--

                      (1) the resulting, surviving or transferee entity fails to
                      assume all the  obligations  of such party or such  Credit
                      Support  Provider  under  this  Agreement  or  any  Credit
                      Support  Document  to  which it or its  predecessor  was a
                      party by  operation  of law or  pursuant  to an  agreement
                      reasonably   satisfactory  to  the  other  party  to  this
                      Agreement; or

                      (2) the benefits of any Credit  Support  Document  fail to
                      extend  (without  the  consent of the other  party) to the
                      performance  by such  resulting,  surviving or  transferee
                      entity of its obligations under this Agreement.

(b) TERMINATION  EVENTS.  The occurrence at any time with respect to a party or,
if applicable, any Credit Support Provider of such party or any Specified Entity
of such party of any event  specified  below  constitutes  an  Illegality if the
event is specified  in (i) below,  a Tax Event if the event is specified in (ii)
below or a Tax Event Upon Merger if the event is specified in (iii) below,  and,
if  specified  to be  applicable,  a Credit  Event  Upon  Merger if the event is
specified pursuant to (iv)

                                       11




below or an Additional Termination Event if the event is specified pursuant to 
(v) below:--

           (i)  ILLEGALITY.  Due to the  adoption  of,  or any  change  in,  any
           applicable law after the date on which a Transaction is entered into,
           or due to the promulgation  of, or any change in, the  interpretation
           by  any  court,  tribunal  or  regulatory  authority  with  competent
           jurisdiction  of any  applicable  law after  such  date,  it  becomes
           unlawful  (other than as a result of a breach by the party of Section
           4(b)) for such party (which will be the Affected Party):--

                      (1) to perform any absolute or  contingent  obligation  to
                      make a payment  or  delivery  or to  receive a payment  or
                      delivery in respect of such  Transaction or to comply with
                      any other material provision of this Agreement relating to
                      such Transaction; or

                      (2) to perform, or for any Credit Support Provider of such
                      party to perform, any contingent or other obligation which
                      the party (or such Credit Support  Provider) has under any
                      Credit Support Document relating to such Transaction;

           (ii) TAX EVENT. Due to (x) any action taken by a taxing authority, or
           brought in a court of competent jurisdiction, on or after the date on
           which a  Transaction  is entered  into  (regardless  of whether  such
           action is taken or brought with respect to a party to this Agreement)
           or (y) a Change in Tax Law,  the party  (which  will be the  Affected
           Party) will,  or there is a substantial  likelihood  that it will, on
           the next succeeding  Scheduled Payment Date (1) be required to pay to
           the other party an additional  amount in respect of an  Indemnifiable
           Tax under  Section  2(d)(i)(4)  (except in respect of interest  under
           Section  2(e),  6(d)(ii) or 6(e)) or (2) receive a payment from which
           an amount is required to be deducted or withheld for or on account of
           a Tax (except in respect of interest under Section 2(e),  6(d)(ii) or
           6(e)) and no  additional  amount is required to be paid in respect of
           such Tax under  Section  2(d)(i)(4)  (other than by reason of Section
           2(d)(i)(4)(A) or
(B));

           (iii) TAX EVENT UPON MERGER.  The party (the "Burdened Party") on the
           next succeeding Scheduled Payment Date will either (1) be required to
           pay an  additional  amount in respect of an  Indemnifiable  Tax under
           Section 2(d)(i)(4) (except in respect of interest under Section 2(e),
           6(d)(ii) or 6(e)) or (2)  receive a payment  from which an amount has
           been deducted or withheld for or on account of any  Indemnifiable Tax
           in respect of which the other party is not

                                       12




           required to pay an additional amount (other than by reason of Section
           2(d)(i)(4)(A)  or  (B)),  in  either  case  as a  result  of a  party
           consolidating  or  amalgamating  with,  or merging  with or into,  or
           transferring all or  substantially  all its assets to, another entity
           (which  will be the  Affected  Party)  where  such  action  does  not
           constitute an event described in Section 5(a)(viii);

           (iv)  CREDIT  EVENT UPON  MERGER.  If "Credit  Event Upon  Merger" is
           specified in the Schedule as applying to the party, such party ("X"),
           any Credit Support  Provider of X or any applicable  Specified Entity
           of X  consolidates  or  amalgamates  with, or merges with or into, or
           transfers all or substantially  all its assets to, another entity and
           such  action  does not  constitute  an  event  described  in  Section
           5(a)(viii) but the  creditworthiness  of the resulting,  surviving or
           transferee  entity is  materially  weaker than that of X, such Credit
           Support  Provider  or such  Specified  Entity,  as the  case  may be,
           immediately  prior  to such  action  (and,  in such  event,  X or its
           successor or transferee, as appropriate, will be the Affected Party);
           or

           (v) ADDITIONAL  TERMINATION  EVENT.  If any  "Additional  Termination
           Event" is specified in the Schedule or any  Confirmation as applying,
           the occurrence of such event (and, in such event,  the Affected Party
           or  Affected  Parties  shall  be as  specified  for  such  Additional
           Termination Event in the Schedule or such Confirmation).

(c) EVENT OF DEFAULT AND  ILLEGALITY.  If an event or  circumstance  which would
otherwise  constitute  or give rise to an Event of Default also  constitutes  an
Illegality, it will be treated as an Illegality and will not constitute an Event
of Default.

6.         EARLY TERMINATION

(a) RIGHT TO TERMINATE  FOLLOWING  EVENT OF DEFAULT.  If at any time an Event of
Default  with  respect to a party (the  "Defaulting  Party") has occurred and is
then continuing,  the other party (the "Non-defaulting  Party") may, by not more
than 20 days notice to the  Defaulting  Party  specifying  the relevant Event of
Default, designate a day not earlier than the day such notice is effective as an
Early Termination Date in respect of all outstanding Transactions.  If, however,
"Automatic  Early  Termination"  is  specified  in the Schedule as applying to a
party, then an Early Termination Date in respect of all outstanding Transactions
will occur  immediately  upon the  occurrence  with  respect to such party of an
Event of Default  specified in Section  5(a)(vii)(1),  (3),  (5), (6) or, to the
extent analogous thereto, (8), and as of the

                                       13





time  immediately  preceding the  institution of the relevant  proceeding or the
presentation  of the relevant  petition upon the occurrence with respect to such
party of an Event of Default specified in Section 5(a)(vii)(4) or, to the extent
analogous thereto, (8).

(b)      RIGHT TO TERMINATE FOLLOWING TERMINATION EVENT.

           (i) NOTICE.  If a Termination  Event occurs,  an Affected Party will,
           promptly  upon  becoming   aware  of  it,  notify  the  other  party,
           specifying  the nature of that  Termination  Event and each  Affected
           Transaction  and will also give such  other  information  about  that
           Termination Event as the other party may reasonably require.

           (ii)  TRANSFER TO AVOID  TERMINATION  EVENT.  If either an Illegality
           under Section  5(b)(i)(1) or a Tax Event occurs and there is only one
           Affected Party, or if a Tax Event Upon Merger occurs and the Burdened
           Party is the Affected Party,  the Affected Party will, as a condition
           to its right to designate  an Early  Termination  Date under  Section
           6(b)(iv),  use all  reasonable  efforts  (which will not require such
           party to incur a loss, excluding immaterial,  incidental expenses) to
           transfer  within 20 days after it gives notice under Section  6(b)(i)
           all its rights and obligations under this Agreement in respect of the
           Affected Transactions to another of its Offices or Affiliates so that
           such Termination Event ceases to exist.

           If the  Affected  Party is not able to make such a  transfer  it will
           give  notice to the other  party to that  effect  within  such 20 day
           period,  whereupon the other party may effect such a transfer  within
           30 days after the notice is given under Section 6(b)(i).

           Any such  transfer by a party  under this  Section  6(b)(ii)  will be
           subject  to and  conditional  upon the prior  written  consent of the
           other party, which consent will not be withheld if such other party's
           policies  in  effect  at such  time  would  permit  it to enter  into
           transactions with the transferee on the terms proposed.

           (iii) TWO AFFECTED PARTIES. If an Illegality under Section 5(b)(i)(1)
           or a Tax Event occurs and there are two Affected Parties,  each party
           will use all  reasonable  efforts to reach  agreement  within 30 days
           after  notice  thereof is given  under  Section  6(b)(i) on action to
           avoid that Termination Event.

                                       14




           (iv)  RIGHT TO TERMINATE.  If:--

                      (1) a transfer  under  Section  6(b)(ii)  or an  agreement
                      under Section 6(b)(iii),  as the case may be, has not been
                      effected with respect to all Affected  Transactions within
                      30 days after an Affected Party gives notice under Section
                      6(b)(i); or

                      (2) an Illegality under Section 5(b)(i)(2), a Credit Event
                      Upon Merger or an Additional  Termination Event occurs, or
                      a Tax Event Upon Merger  occurs and the Burdened  Party is
                      not the Affected Party,

           either party in the case of an Illegality,  the Burdened Party in the
           case of a Tax Event Upon Merger,  any Affected Party in the case of a
           Tax Event or an  Additional  Termination  Event if there is more than
           one Affected  Party,  or the party which is not the Affected Party in
           the case of a Credit Event Upon Merger or an  Additional  Termination
           Event if there is only one  Affected  Party may,  by not more than 20
           days  notice  to the  other  party  and  provided  that the  relevant
           Termination  Event is then  continuing,  designate  a day not earlier
           than the day such notice is effective as an Early Termination Date in
           respect of all Affected Transactions.

(c)      EFFECT OF DESIGNATION.

           (i) If notice  designating an Early  Termination  Date is given under
           Section  6(a) or (b),  the Early  Termination  Date will occur on the
           date so  designated,  whether or nor the relevant Event of Default or
           Termination Event is then continuing.

           (ii)  Upon  the  occurrence  or  effective  designation  of an  Early
           Termination  Date, no further  payments or  deliveries  under Section
           2(a)(i)  or 2(e) in respect of the  Terminated  Transactions  will be
           required to be made, but without prejudice to the other provisions of
           this Agreement.  The amount,  if any,  payable in respect of an Early
           Termination Date shall be determined pursuant to Section 6(e).

                                       15





(d)      CALCULATIONS.

           (i) STATEMENT.  On or as soon as reasonably practicable following the
           occurrence  of an Early  Termination  Date,  each party will make the
           calculations  on its part, if any,  contemplated  by Section 6(e) and
           will  provide  to  the  other  party  a  statement  (1)  showing,  in
           reasonable   detail,   such  calculations   (including  all  relevant
           quotations  and specifying any amount payable under Section 6(e)) and
           (2)  giving  details  of the  relevant  account  to which any  amount
           payable to it is to be paid.  In the absence of written  confirmation
           from the  source of a  quotation  obtained  in  determining  a Market
           Quotation,  the records of the party obtaining such quotation will be
           conclusive evidence of the existence and accuracy of such quotation.

           (ii) PAYMENT  DATE.  An amount  calculated as being due in respect of
           any Early  Termination Date under Section 6(e) will be payable on the
           date that notice of the amount  payable is effective  (in the case of
           an Early  Termination  Date which is designated or occurs as a result
           of an Event of  Default)  and on the day which is two Local  Business
           Days after the day on which notice of the amount payable is effective
           (in the case of an Early  Termination  Date which is  designated as a
           result of a  Termination  Event).  Such amount will be paid  together
           with (to the extent  permitted under applicable law) interest thereon
           (before as well as after judgment) in the Termination Currency,  from
           (and  including)  the  relevant  Early   Termination   Date  to  (but
           excluding) the date such amount is paid, at the Applicable Rate. Such
           interest will be calculated on the basis of daily compounding and the
           actual number of days elapsed.

(e) PAYMENTS ON EARLY  TERMINATION.  If an Early  Termination  Date occurs,  the
following  provisions shall apply based on the parties' election in the Schedule
of a payment measure, either "Market Quotation" or "Loss", and a payment method,
either the  "First  Method"  or the  "Second  Method".  If the  parties  fail to
designate a payment measure or payment method in the Schedule, it will be deemed
that "Market Quotation" or the "Second Method", as the case may be, shall apply.
The  amount,  if any,  payable  in  respect  of an  Early  Termination  Date and
determined pursuant to this Section will be subject to any Set-off.

           (i) EVENTS OF DEFAULT.  If the Early Termination Date results from an
           Event of Default:--

                                       16





                      (1) First Method and Market Quotation. If the First Method
                      and Market  Quotation apply, the Defaulting Party will pay
                      to the  Non-defaulting  Party the  excess,  if a  positive
                      number,   of  (A)  the  sum  of  the   Settlement   Amount
                      (determined by the Non-defaulting Party) in respect of the
                      Terminated   Transactions  and  the  Termination  Currency
                      Equivalent   of   the   Unpaid   Amounts   owing   to  the
                      Non-defaulting  Party  over (B) the  Termination  Currency
                      Equivalent of the Unpaid  Amounts owing to the  Defaulting
                      Party.

                      (2) First  Method and Loss.  If the First  Method and Loss
                      apply,   the  Defaulting   Party  will  pay  to  the  Non-
                      defaulting Party, if a positive number, the Non-defaulting
                      Party's Loss in respect of this Agreement.

                      (3)  Second  Method and  Market  Quotation.  If the Second
                      Method  and  Market  Quotation  apply,  an amount  will be
                      payable  equal  to (A)  the sum of the  Settlement  Amount
                      (determined by the Non-defaulting Party) in respect of the
                      Terminated   Transactions  and  the  Termination  Currency
                      Equivalent   of   the   Unpaid   Amounts   owing   to  the
                      Non-defaulting  Party  less (B) the  Termination  Currency
                      Equivalent of the Unpaid  Amounts owing to the  Defaulting
                      Party. If that amount is a positive number, the Defaulting
                      Party will pay it to the Non-defaulting  Party; if it is a
                      negative  number,  the  Non-defaulting  Party will pay the
                      absolute value of that amount to the Defaulting Party.

                      (4) Second  Method and Loss. If the Second Method and Loss
                      apply,   an   amount   will  be   payable   equal  to  the
                      Non-defaulting  Party's Loss in respect of this Agreement.
                      If that amount is a positive number,  the Defaulting Party
                      will  pay  it  to  the  Non-defaulting  Party;  if it is a
                      negative  number,  the  Non-defaulting  Party will pay the
                      absolute value of that amount to the Defaulting Party.

           (ii) TERMINATION EVENTS. If the Early Termination Date results from a
           Termination Event: --

                      (1) One Affected  Party.  If there is one Affected  Party,
                      the amount  payable will be determined in accordance  with
                      Section  6(e)(i)(3),   if  Market  Quotation  applies,  or
                      Section  6(e)(i)(4),  if Loss  applies,  except  that,  in
                      either case, references to the Defaulting Party and to the
                      Non-

                                       17





             defaulting Party will be deemed to be references to the
          Affected Party and the party which is not the Affected Party,
            respectively, and, if Loss applies and fewer than all the
         Transactions are being terminated, Loss shall be calculated in
                     respect of all Terminated Transactions.

                  (2) Two Affected Parties. If there are two Affected Parties:--

                                 (A) if Market  Quotation  applies,  each  party
                                 will  determine a Settlement  Amount in respect
                                 of the Terminated  Transactions,  and an amount
                                 will  be  payable  equal  to (I) the sum of (a)
                                 one-half   of  the   difference   between   the
                                 Settlement  Amount of the party with the higher
                                 Settlement  Amount  ("X")  and  the  Settlement
                                 Amount of the party  with the lower  Settlement
                                 Amount ("Y") and (b) the  Termination  Currency
                                 Equivalent  of the  Unpaid  Amounts  owing to X
                                 less (II) the Termination  Currency  Equivalent
                                 of the Unpaid Amounts owing to Y; and

                                 (B) if Loss applies,  each party will determine
                                 its Loss in respect of this  Agreement  (or, if
                                 fewer  than  all  the  Transactions  are  being
                                 terminated,   in  respect  of  all   Terminated
                                 Transactions)  and an  amount  will be  payable
                                 equal to one-half of the difference between the
                                 Loss of the party  with the  higher  Loss ("X")
                                 and the Loss of the party with the lower Loss
("Y").

                      If the amount payable is a positive  number, Y will pay it
                      to X; if it is negative  number,  X will pay the  absolute
                      value of that amount to Y.

           (iii)  ADJUSTMENT FOR  BANKRUPTCY.  In  circumstances  where an Early
           Termination Date occurs because "Automatic Early Termination" applies
           in respect of a party, the amount  determined under this Section 6(e)
           will be subject to such  adjustments as are appropriate and permitted
           by law to reflect any payments or deliveries made by one party to the
           other under this  Agreement (and retained by such other party) during
           the period from the relevant Early  Termination  Date to the date for
           payment determined under Sections 6(d)(ii).

           (iv) PRE-ESTIMATE. The parties agree that if Market Quotation applies
           an  amount  recoverable  under  this  Section  6(e)  is a  reasonable
           pre-estimate  of loss and not a penalty.  Such  amount is payable for
           the loss of bargain and the loss of protection  against  future risks
           and except as otherwise provided in this

                                       18





           Agreement  neither  party will be entitled to recover any  additional
damages as a consequence of such losses.

7.         TRANSFER


Subject  to  Section  6(b)(ii),  neither  this  Agreement  nor any  interest  or
obligation  in or under this  Agreement  may be  transferred  (whether by way of
security or otherwise) by either party without the prior written  consent of the
other party, except that:--

(a)  a  party  may  make  such  a  transfer  of  this  Agreement  pursuant  to a
consolidation  or amalgamation  with, or merger with or into, or transfer of all
or substantially all its assets to, another entity (but without prejudice to any
other right or remedy under this Agreement); and

(b) a party may make such a transfer  of all or any part of its  interest in any
amount payable to it from a Defaulting Party under Section 6(e).

Any purported transfer that is not in compliance with this Section will be void.

8.         CONTRACTUAL CURRENCY

(a) PAYMENT IN THE CONTRACTUAL CURRENCY.  Each payment under this Agreement will
be made in the relevant  currency  specified in this  Agreement for that payment
(the  "Contractual  Currency").  To the extent  permitted by applicable law, any
obligation to make payments  under this  Agreement in the  Contractual  Currency
will not be discharged or satisfied by any tender in any currency other than the
Contractual  Currency,  except to the extent such  tender  results in the actual
receipt by the party to which payment is owed, acting in a reasonable manner and
in good faith in  converting  the  currency  so  tendered  into the  Contractual
Currency,  of the full amount in the Contractual Currency of all amounts payable
in respect of this  Agreement.  If for any reason the amount in the  Contractual
Currency  so  received  falls  short of the amount in the  Contractual  Currency
payable in respect of this  Agreement,  the party  required  to make the payment
will, to the extent permitted by applicable law, immediately pay such additional
amount in the  Contractual  Currency as may be necessary to  compensate  for the
shortfall.  If for any reason the amount in the Contractual Currency so received
exceeds  the  amount in the  Contractual  Currency  payable  in  respect of this
Agreement,  the party  receiving the payment will refund  promptly the amount of
such excess.

                                       19





(b)  JUDGMENTS.  To the extent  permitted by applicable  law, if any judgment or
order  expressed in a currency other than the  Contractual  Currency is rendered
(i) for the payment of any amount owing in respect of this  Agreement,  (ii) for
the payment of any amount  relating to any early  termination in respect of this
Agreement  or (iii) in respect of a judgment  or order of another  court for the
payment  of any  amount  described  in (i) or  (ii)  above,  the  party  seeking
recovery,  after recovery in full of the aggregate amount to which such party is
entitled  pursuant  to the  judgment  or  order,  will be  entitled  to  receive
immediately  from the other party the amount of any shortfall of the Contractual
Currency  received  by such  party as a  consequence  of sums paid in such other
currency  and  will  refund  promptly  to the  other  party  any  excess  of the
Contractual  Currency  received by such party as a  consequence  of sums paid in
such other  currency if such shortfall or such excess arises or results from any
variation  between  the rate of exchange  at which the  Contractual  Currency is
converted  into the  currency of the  judgment or order for the purposes of such
judgment or order and the rate of  exchange at which such party is able,  acting
in a reasonable  manner and in good faith in  converting  the currency  received
into the Contractual  Currency,  to purchase the  Contractual  Currency with the
amount of the currency of the judgment or order actually received by such party.
The term "rate of exchange" includes, without limitation, any premiums and costs
of exchange  payable in connection  with the purchase of or conversion  into the
Contractual Currency.

(c) SEPARATE  INDEMNITIES.  To the extent  permitted by  applicable  law,  these
indemnities  constitute  separate  and  independent  obligations  form the other
obligations in this  Agreement,  will be enforceable as separate and independent
causes of action, will apply notwithstanding any indulgence granted by the party
to which any payment is owed and will not be affected by judgment being obtained
or claim or proof  being  made for any other  sums  payable  in  respect of this
Agreement.

(d) EVIDENCE OF LOSS.  For the purpose of this Section 8, it will be  sufficient
for a party to  demonstrate  that it would  have  suffered  a loss had an actual
exchange or purchase been made.

9.         MISCELLANEOUS

(a) ENTIRE  AGREEMENT.  This  Agreement  constitutes  the entire  agreement  and
understanding  of the parties with respect to its subject  matter and supersedes
all oral communication and prior writings with respect thereto.

                                       20





(b)  AMENDMENTS.  No  amendment,  modification  or  waiver  in  respect  of this
Agreement will be effective unless in writing  (including a writing evidenced by
a facsimile transmission) and executed by each of the parties or confirmed by an
exchange of telexes or electronic messages on an electronic messaging system.

(c)  SURVIVAL  OF  OBLIGATIONS.  Without  prejudice  to Sections  2(a)(iii)  and
6(c)(ii),  the  obligations of the parties under this Agreement will survive the
termination of any Transaction.

(d)  REMEDIES  CUMULATIVE.  Except as  provided in this  Agreement,  the rights,
powers,  remedies and  privileges  provided in this Agreement are cumulative and
not exclusive of any rights, powers, remedies and privileges provided by law.

(e)      COUNTERPARTS AND CONFIRMATIONS.

           (i) This Agreement (and each  amendment,  modification  and waiver in
           respect  of  it)  may  be  executed  and  delivered  in  counterparts
           (including by facsimile  transmission),  each of which will be deemed
           an original.

           (ii) The parties  intend that they are legally  bound by the terms of
           each  Transaction  from the moment they agree to those terms (whether
           orally or otherwise). A Confirmation shall be entered into as soon as
           practicable  and  may  be  executed  and  delivered  in  counterparts
           (including by facsimile transmission) or be created by an exchange of
           telexes or by an exchange  of  electronic  messages on an  electronic
           messaging  system,  which in each  case  will be  sufficient  for all
           purposes  to evidence a binding  supplement  to this  Agreement.  The
           parties will specify therein or through another  effective means that
           any such  counterpart,  telex or  electronic  message  constitutes  a
           Confirmation.

(f) NO WAIVER OF RIGHTS.  A failure or delay in exercising  any right,  power or
privilege  in respect of this  Agreement  will not be  presumed  to operate as a
waiver,  and a single or partial exercise of any right,  power or privilege will
not be presumed to preclude any subsequent or further  exercise,  of that right,
power or privilege or the exercise of any other right, power or privilege.

(g)  HEADINGS.  The  headings  used in this  Agreement  are for  convenience  of
reference  only and are not to affect  the  construction  of or to be taken into
consideration in interpreting this Agreement.

                                       21





10.        OFFICES; MULTIBRANCH PARTIES

(a) If Section  10(a) is specified in the Schedule as applying,  each party that
enters into a  Transaction  through an Office other than its head or home office
represents to the other party that,  notwithstanding the place of booking office
or jurisdiction of  incorporation or organisation of such party, the obligations
of such party are the same as if it had entered into the Transaction through its
head or home office.  This  representation will be deemed to be repeated by such
party on each date on which a Transaction is entered into.

(b)  Neither  party may change the Office  through  which it makes and  receives
payment or deliveries for the purpose of a Transaction without the prior written
consent of the other party.

(c) If a party  is  specified  as a  Multibranch  Party  in the  Schedule,  such
Multibranch  Party  may  make and  receive  payments  or  deliveries  under  any
Transaction  through any Office listed in the Schedule,  and the Office  through
which it makes and receives payments or deliveries with respect to a Transaction
will be specified in the relevant Confirmation.

11.        EXPENSES


A Defaulting Party will, on demand,  indemnify and hold harmless the other party
for and against all reasonable out-of-pocket expenses,  including legal fees and
Stamp  Tax,  incurred  by such  other  party by  reason of the  enforcement  and
protection of its rights under this Agreement or any Credit Support  Document to
which the Defaulting  Party is a party or by reason of the early  termination of
any Transaction, including, but not limited to, costs of collection.

12.        NOTICES

(a)  EFFECTIVENESS.  Any  notice  or  other  communication  in  respect  of this
Agreement  may be given in any manner set forth below  (except  that a notice or
other  communication  under  Section  5 or 6  may  not  be  given  by  facsimile
transmission  or  electronic  messaging  system) to the  address or number or in
accordance  with the  electronic  messaging  system  details  provided  (see the
Schedule) and will be deemed effective as indicated:--

                                       22





           (i) if in writing and delivered in person or by courier,  on the date
           it is delivered;

           (ii) if sent by  telex,  on the date the  recipient's  answerback  is
           received;

           (iii)  if  sent  by   facsimile   transmission,   on  the  date  that
           transmission  is received by a responsible  employee of the recipient
           in legible form (it being  agreed that the burden of proving  receipt
           will be on the  sender and will not be met by a  transmission  report
           generated by the sender's facsimile machine);

           (iv) if sent by certified or registered  mail (airmail,  if overseas)
           or the equivalent (return receipt  requested),  on the date that mail
           is delivered or its delivery is attempted; or

           (v)  if  sent  by  electronic  messaging  system,  on the  date  that
           electronic message is received,

unless the date of that  delivery (or attempted  delivery) or that  receipt,  as
applicable,  is not a Local Business Day or that  communication is delivered (or
attempted) or received,  as  applicable,  after the close of business on a Local
Business  Day,  in which  case  that  communication  shall be  deemed  given and
effective on the first following day that is a Local Business Day.

(b)  CHANGE OF  ADDRESSES.  Either  party may by notice to the other  change the
address,  telex, or facsimile  number or electronic  messaging system details at
which notices or other communications are to be given to it.

13.        GOVERNING LAW AND JURISDICTION.

(a) GOVERNING LAW.This Agreement will be governed by and construed in accordance
with the law specified in the Schedule.

(b) JURISDICTION.  With respect to any suit,  action or proceedings  relating to
this Agreement ("Proceedings"), each party irrevocably:--

           (i)  submits  to the  jurisdiction  of the  English  courts,  if this
           Agreement  is  expressed  to be  governed  by English  law, or to the
           non-exclusive jurisdiction of the courts of the State of New York and
           the United States District Court

                                       23




           located  in the  Borough  of  Manhattan  in New  York  City,  if this
           Agreement is expressed to be governed by the laws of the State of New
           York; and

           (ii) waives any objection which it may have at any time to the laying
           of venue of any  Proceedings  brought in any such  court,  waives any
           claim that such  Proceedings  have been  brought  in an  inconvenient
           forum and further  waives the right to object,  with respect to other
           Proceedings, that such court does not have any jurisdiction over such
           party.

Nothing in this Agreement  precludes  either party from bringing  Proceedings in
any other jurisdiction  (outside,  if this Agreement is expressed to be governed
by English law, the Contracting  States, as defined in Section 1(3) of the Civil
Jurisdiction  and  Judgments  Act  1982  or  any   modification,   extension  or
re-enactment  thereof  for the time  being in force)  nor will the  bringing  of
Proceedings  in  any  one  or  more  jurisdictions   preclude  the  bringing  of
Proceedings in any other jurisdiction.

(c) SERVICE OF PROCESS.  Each party  irrevocably  appoints the Process Agent (if
any) specified  opposite its name in the Schedule to receive,  for it and on its
behalf,  service of process in any  Proceedings.  If for any reason any  party's
Process  Agent is unable to act as such,  such  party will  promptly  notify the
other party and within 30 days appoint a substitute  process  agent to the other
party. The parties irrevocably consent to service of process given in the manner
provided for notices in Section 12.  Nothing in this  Agreement  will affect the
right of either party to serve process in any other manner permitted by law.

(d) WAIVER OF IMMUNITIES.  Each party irrevocably  waives, to the fullest extent
permitted by applicable  law, with respect to itself and its revenues and assets
(irrespective  of their use or  intended  use),  all  immunity on the grounds of
sovereignty or other similar  grounds from (i) suit,  (ii)  jurisdiction  of any
court, (iii) relief by way of injunction,  order for specific performance or for
recovery of property,  (iv)  attachments of its assets  (whether before or after
judgment)  and (v) execution or  enforcement  of any judgment to which it or its
revenues or assets might  otherwise be entitled in any Proceedings in the courts
of  any  jurisdiction  and  irrevocably  agrees,  to  the  extent  permitted  by
applicable law, that it will not claim any such immunity in any Proceedings.

                                       24





14.        DEFINITIONS

As used in this Agreement.


"ADDITIONAL TERMINATION EVENT" has the meaning specified in Section 5(b).

"AFFECTED PARTY" has the meaning specified in Section 5(b).

"AFFECTED  TRANSACTIONS"  means  (a)  with  respect  to  any  Termination  Event
consisting  of  an  Illegality,   Tax  Event  or  Tax  Event  Upon  Merger,  all
Transactions  affected by the occurrence of such Termination  Event and (b) with
respect to any other Termination Event, all Transactions.

"AFFILIATE"  means,  subject to the  Schedule,  in relation  to any person,  any
entity  controlled,  directly  or  indirectly,  by the  person,  any entity that
controls,  directly  or  indirectly,  the  person  or  any  entity  directly  or
indirectly under common control with the person. For this purpose,  "control" of
any entity or person  means  ownership  of a majority of the voting power of the
entity or person.

"APPLICABLE RATE" means: --

(a) in respect of obligations  payable or deliverable  (or which would have been
but for Section 2(a)(iii)) by a Defaulting Party, the Default Rate;

(b) in respect of an  obligation  to pay an amount under  Section 6(e) of either
party from and after the date  (determined in accordance with Section  6(d)(ii))
on which that amount is payable, the Default Rate;

(c) in respect of all other  obligations  payable or deliverable (or which would
have  been  but  for  Section   2(a)(iii))  by  a   Non-defaulting   Party,  the
Non-defaulting Rate; and

(d) in all other cases, the Terminating Rate.

"BURDENED PARTY" has the meaning specified in Section 5(b).

"CHANGE IN TAX LAW" means the enactment, promulgation, execution or ratification
of, or any change in or amendment to, any law (or in the application or official

                                       25





interpretation  of any  law)  that  occurs  on or after  the  date on which  the
relevant Transaction is entered into.

"CONSENT"  includes  a  consent,  approval,  action,  authorisation,  exemption,
notice, filing, registration or exchange control consent.

"CREDIT EVENT UPON MERGER" has the meaning specified in Section 5(b).

"CREDIT SUPPORT DOCUMENT" means any agreement or instrument that is specified as
such in this Agreement.

"CREDIT SUPPORT PROVIDER" has the meaning specified in the Schedule.

"DEFAULT  RATE"  means a rate per  annum  equal to the  cost  (without  proof or
evidence of any actual  cost) to the relevant  payee (as  certified by it) if it
were to fund or of funding the relevant amount plus 1% per annum.

"DEFAULTING PARTY" has the meaning specified in Section 6(a).

"EARLY  TERMINATION  DATE" means the date  determined in accordance with Section
6(a) or 6(b)(iv).

"EVENT OF DEFAULT" has the meaning specified in Section 5(a) and, if applicable,
in the Schedule.

"ILLEGALITY" has the meaning specified in Section 5(b).

"INDEMNIFIABLE  TAX" means any Tax other than a Tax that would not be imposed in
respect of a payment under this Agreement but for a present or former connection
between the jurisdiction of the government or taxation  authority  imposing such
Tax and the  recipient  of such  payment or a person  related to such  recipient
(including,  without  limitation,  a connection  arising from such  recipient or
related person being or having been a citizen or resident of such  jurisdiction,
or being or having been organised,  present or engaged in a trade or business in
such  jurisdiction,  or having or having had a permanent  establishment or fixed
place of business in such  jurisdiction,  but  excluding  a  connection  arising
solely  from such  recipient  or  related  person  having  executed,  delivered,
performed  its  obligations  or  received a payment  under,  or  enforced,  this
Agreement or a Credit Support Document).

                                       26





"LAW" includes any treaty, law, rule or regulation (as modified,  in the case of
tax matters, by the practice of any relevant governmental revenue authority) and
"LAWFUL" and "UNLAWFUL" will be construed accordingly.

"LOCAL BUSINESS DAY" means,  subject to the Schedule,  a day on which commercial
banks are open for business  (including dealings in foreign exchange and foreign
currency  deposits) (a) in relation to any obligation under Section 2(a)(i),  in
the place(s) specified in the relevant Confirmation or, if not so specified,  as
otherwise agreed by the parties in writing or determined  pursuant to provisions
contained, or incorporated by reference,  in this Agreement,  (b) in relation to
any other  payment,  in the place where the relevant  account is located and, if
different,  in the principal  financial  centre, if any, of the currency of such
payment, (c) in relation to any notice or other communication,  including notice
contemplated  under Section  5(a)(i),  in the city  specified in the address for
notice  provided by the recipient and, in the case of a notice  contemplated  by
Section  2(b),  in the place where the relevant new account is to be located and
(d) in relation to Section 5(a)(v)(2), in the relevant locations for performance
with respect to such Specified Transaction.

"LOSS"  means,  with  respect  to  this  Agreement  or  one or  more  Terminated
Transactions,  as the  case  may  be,  and a  party,  the  Termination  Currency
Equivalent of an amount that party reasonably determines in good faith to be its
total losses and costs (or gain, in which case  expressed as a negative  number)
in connection  with this  Agreement or that  Terminated  Transaction or group of
Terminated Transactions, as the case may be, including any loss of bargain, cost
of funding or, at the  election of such party but without  duplication,  loss or
cost  incurred  as a  result  of  its  terminating,  liquidating,  obtaining  or
reestablishing any hedge or related trading position (or any gain resulting from
any of them).  Loss  includes  losses  and costs (or  gains) in  respect  of any
payment or delivery  required to have been made (assuming  satisfaction  of each
applicable condition precedent) on or before the relevant Early Termination Date
and not made, except, so as to avoid  duplication,  if Section 6(e)(i)(1) or (3)
or  6(e)(ii)(2)(A)  applies.  Loss does not  include a  party's  legal  fees and
out-of-pocket  expenses referred to under Section 11. A party will determine its
Loss as of the relevant  Early  Termination  Date, or, if that is not reasonably
practicable,  as of the earliest date thereafter as is reasonably practicable. A
party  may (but need not)  determine  its Loss by  reference  to  quotations  of
relevant  rates or  prices  from one or more  leading  dealers  in the  relevant
markets.

"MARKET  QUOTATION" means,  with respect to one or more Terminated  Transactions
and a party  making  the  determination,  an amount  determined  on the basis of
quotations

                                       27





from Reference Market-makers. Each quotation will be for an amount, if any, that
would be paid to such party  (expressed  as a negative  number) or by such party
(expressed as a positive number) in  consideration of an agreement  between such
party (taking into account any existing Credit Support  Document with respect to
the obligations of such party) and the quoting  Reference  Market-maker to enter
into a transaction (the "Replacement Transaction") that would have the effect of
preserving  for such party the  economic  equivalent  of any payment or delivery
(whether the  underlying  obligation was absolute or contingent and assuming the
satisfaction  of each  applicable  condition  precedent)  by the  parties  under
Section 2(a)(i) in respect of such Terminated Transaction or group of Terminated
Transactions   that  would,  but  for  the  occurrence  of  the  relevant  Early
Termination  Date, have been required after that date. For this purpose,  Unpaid
Amounts  in  respect  of the  Terminated  Transaction  or  group  of  Terminated
Transactions are to be excluded but, without limitation, any payment or delivery
that would,  but for the relevant  Early  Termination  Date,  have been required
(assuming  satisfaction of each applicable condition precedent) after that Early
Termination Date is to be included. The Replacement Transaction would be subject
to such documentation as such party and the Reference  Market-maker may, in good
faith,  agree.  The party making the  determination  (or its agent) will request
each Reference  Market-maker  to provide its quotation to the extent  reasonably
practicable as of the same day and time (without regard to different time zones)
on or as soon as reasonably  practicable  after the relevant  Early  Termination
Date.  The day and time as of which those  quotations are to be obtained will be
selected  in good  faith by the  party  obliged  to make a  determination  under
Section  6(e),  and, if each party is so obliged,  after  consultation  with the
other. If more than three quotations are provided,  the Market Quotation will be
the arithmetic mean of the quotations,  without regard to the quotations  having
the highest and lowest  values.  If exactly three such  quotations are provided,
the Market  Quotation will be the quotation  remaining  after  disregarding  the
highest and lowest quotations.  For this purpose, if more than one quotation has
the same highest value or lowest  value,  then one of such  quotations  shall be
disregarded. If fewer than three quotations are provided, it will be deemed that
the  Market  Quotation  in respect of such  Terminated  Transaction  or group of
Terminated Transactions cannot be determined.

"NON-DEFAULT  RATE" means a rate per annum equal to the cost  (without  proof or
evidence of any actual cost) to the Non-defaulting Party (as certified by it) if
it were to fund the relevant amount.

"NON-DEFAULTING PARTY" has the meaning specified in Section 6(a).

                                       28





"OFFICE" means a branch or office of a party,  which may be such party's head or
home office.

"POTENTIAL EVENT OF DEFAULT" means any event which, with the giving of notice or
the lapse of time or both, would constitute an Event of Default.

"REFERENCE  MARKET-MAKERS"  means four leading  dealers in the  relevant  market
selected  by the party  determining  a Market  Quotation  in good faith (a) from
among dealers of the highest credit standing which satisfy all the criteria that
such party applies generally at the time in deciding whether to offer or to make
an  extension  of credit  and (b) to the  extent  practicable,  from  among such
dealers having an office in the same city.

"RELEVANT JURISDICTION" means, with respect to a party, the jurisdictions (a) in
which the party is incorporated, organised, managed and controlled or considered
to have its  seat,  (b) where an Office  through  which the party is acting  for
purposes of this  Agreement  is located,  (c) in which the party  executes  this
Agreement and (d) in relation to any payment, from or through which such payment
is made.

"SCHEDULED  PAYMENT  DATE"  means a date on which a payment or delivery is to be
made under Section 2(a)(i) with respect to a Transaction.

"SET-OFF" means set-off, offset,  combination of accounts, right of retention or
withholding  or  similar  right or  requirement  to which the payer of an amount
under Section 6 is entitled or subject  (whether  arising under this  Agreement,
another contract,  applicable law or otherwise) that is exercised by, or imposed
on, such payer.

"SETTLEMENT  AMOUNT"  means,  with respect to a party and any Early  Termination
Date, the sum of:--

(a) the  Termination  Currency  Equivalent  of the  Market  Quotations  (whether
positive or negative)  for each  Terminated  Transaction  or group of Terminated
Transactions for which a Market Quotation is determined; and

(b) such party's Loss (whether positive or negative and without reference to any
Unpaid  Amounts)  for  each  Terminated   Transaction  or  group  of  Terminated
Transactions  for which a market Quotation cannot be determined or would not (in
the  reasonable  belief  of  the  party  making  the  determination)  produce  a
commercially reasonable result.

                                       29





"SPECIFIED ENTITY" has the meaning specified in the Schedule.

"SPECIFIED INDEBTEDNESS" means, subject to the Schedule, any obligation (whether
present or future, contingent or otherwise, as principal or surety or otherwise)
in respect of borrowed money.

"SPECIFIED  TRANSACTION"  means,  subject to the Schedule,  (a) any  transaction
(including an agreement with respect thereto) now existing or hereafter  entered
into between one party to this Agreement (or any Credit Support Provider of such
party or any applicable  Specified  Entity of such party) and the other party to
this  Agreement  (or any Credit  Support  Provider  of such  other  party or any
applicable  Specified  Entity  of  such  other  party)  which  is  a  rate  swap
transaction,  basis swap,  forward rate transaction,  commodity swap,  commodity
option, equity or equity index swap, equity or equity index option, bond option,
interest rate option,  foreign  exchange  transaction,  cap  transaction,  floor
transaction, collar transaction, currency swap transaction,  cross-currency rate
swap transaction,  currency option or any other similar  transaction  (including
any option with respect to any of these  transactions),  (b) any  combination of
these  transactions  and (c) any other  transaction  identified  as a  Specified
Transaction in this Agreement or the relevant confirmation.

"STAMP TAX" means any stamp, registration, documentation or similar tax.

"TAX" means any present or future tax, levy, impost, duty, charge, assessment or
fee of any nature (including interest,  penalties and additions thereto) that is
imposed by any  government  or other taxing  authority in respect of any payment
under this Agreement other than a stamp, registration,  documentation or similar
tax.

"TAX EVENT" has the meaning specified in Section 5(b).

"TAX EVENT UPON MERGER" has the meaning specified in Section 5(b).

"TERMINATED  TRANSACTIONS"  means with respect to any Early Termination Date (a)
if resulting  from a Termination  Event,  all Affected  Transactions  and (b) if
resulting from an Event of Default,  all Transactions (in either case) in effect
immediately  before  the  effectiveness  of the  notice  designating  that Early
Termination  Date (or, if "Automatic  Early  Termination"  applies,  immediately
before that Early Termination Date).

                                       30





"TERMINATION CURRENCY" has the meaning specified in the Schedule.

"TERMINATION CURRENCY EQUIVALENT" means, in respect of any amount denominated in
the Termination  Currency,  such Termination  Currency amount and, in respect of
any amount  denominated in a currency other than the  Termination  Currency (the
"Other  Currency"),  the amount in the  Termination  Currency  determined by the
party  making the  relevant  determination  as being  required to purchase  such
amount of such Other Currency as at the relevant Early  Termination Date, or, if
the relevant Market  Quotation or Loss (as the case may be), is determined as of
a later date, that later date,  with the Termination  Currency at the rate equal
to the spot exchange rate of the foreign  exchange  agent  (selected as provided
below) for the purchase of such Other Currency with the Termination  Currency at
or about  11:00  a.m.  (in the  city in which  such  foreign  exchange  agent is
located) on such date as would be customary for the determination of such a rate
for the  purchase  of such  Other  Currency  for  value  on the  relevant  Early
Termination  Date or that later date.  The foreign  exchange agent will, if only
one party is obliged to make a determination  under Section 6(e), be selected in
good faith by that party and otherwise will be agreed by the parties.

"TERMINATION EVENT" means an Illegality,  a Tax Event or a Tax Event Upon Merger
or, if specified to be  applicable,  a Credit Event Upon Merger or an Additional
Termination Event.

"TERMINATION  RATE" means a rate per annum equal to the  arithmetic  mean of the
cost (without  proof or evidence of any actual cost) to each party (as certified
by such party) if it were to fund or of funding such amounts.

"UNPAID AMOUNTS" owing to any party means,  with respect to an Early Termination
Date,  the  aggregate  of (a) in respect  of all  Terminated  Transactions,  the
amounts that became  payable (or that would have become  payable but for Section
2(a)(iii)  to such  party  under  Section  2(a)(i)  on or  prior  to such  Early
Termination  Date and which remain unpaid as at such Early  Termination Date and
(b) in respect of each Terminated Transaction, for each obligation under Section
2(a)(i) which was (or would have been but for Section 2(a)(iii))  required to be
settled by delivery to such party on or prior to such Early Termination Date and
which has not been so settled as at such Early Termination Date, an amount equal
to the fair market  value of that which was (or would have been)  required to be
delivered  as of the  originally  scheduled  date  for  delivery,  in each  case
together with (to the extent  permitted under  applicable law) interest,  in the
currency  of such  amounts,  from  (and  including)  the date  such  amounts  or
obligations were or would have been required to have been paid

                                       31





or performed to (but excluding) such Early  Termination  Date, at the Applicable
Rate.  Such  amounts  of  interest  will be  calculated  on the  basis  of daily
compounding and the actual number of days elapsed.  The fair market value of any
obligation referred to in clause (b) above shall be reasonably determined by the
party obliged to make the determination  under Section 6(e) or, if each party is
so obliged, it shall be the average of the Termination  Currency  Equivalents of
the fair market values reasonably determined by both parties.

IN WITNESS  WHEREOF the parties have executed  this  document on the  respective
dates  specified  below with effect from the date specified on the first page of
this document.


   SWISS BANK CORPORATION, LONDON BRANCH       INTERNEURON PHARMACEUTICALS, INC.


By:  /s/ Thomas Eggenschwiler                  By:  Thomas F. Farb
     ------------------------------                 ----------------------------
Name:  Thomas Eggenschwiler                    Name:  Thomas F. Farb
Title:  Attorney-in-Fact                       Title: Executive Vice President -
                                                       Finance
Date: 5 - May 1997                             Date:  May 5, 1997


By: /s/ Alfred C. Kellogg
    -------------------------------
Name:  Alfred C. Kellogg
Title:  Attorney-in-Fact
Date:  May 5, 1997





                                       32








                                    SCHEDULE
                             TO THE MASTER AGREEMENT

                             DATED AS OF MAY 5, 1997

                                     BETWEEN

SWISS BANK CORPORATION,          AND            INTERNEURON                    
LONDON BRANCH                                   PHARMACEUTICALS, INC., a       
                                                corporation organized under the
                                                laws of the State of Delaware  
                                                  
  ("Party A")                                          ("Party B")


                                     PART 1
                             TERMINATION PROVISIONS

In this Agreement:

(a)      "SPECIFIED ENTITY" means in relation to Party A for the purpose of:

         Section 5(a)(v),                                               NONE

         Section 5(a)(vi),                                              NONE

         Section 5(a)(vii),                                             NONE

         Section 5(b)(iv),                                              NONE

         and in relation to Party B for the purpose of:

         Section 5(a)(v),                                               NONE

         Section 5(a)(vi),                                              NONE

         Section 5(a)(vii),                                             NONE

         Section 5(b)(iv),                                              NONE

(b)      The  definition  of  "SPECIFIED  TRANSACTION"  shall  have the  meaning
specified in Section 14 of the Agreement.

(c)      The "CROSS DEFAULT"  provisions of Section 5 (a)(vi) will apply to both
parties,  as amended by deleting the phrase "or becoming capable at such time of
being  declared,"  and shall  exclude any default that results  solely from wire
transfer   difficulties  or  an  error  or  omission  of  an  administrative  or
operational  nature (so long as  sufficient  funds are available to the relevant
party on the relevant  date),  but only if payment is made within three Business
Days  after  such  transfer  difficulties  have been  corrected  or the error or
omission has been discovered.

         If such provisions apply:


                                        1





         "SPECIFIED  INDEBTEDNESS"  means any  obligation  (whether  present  or
future, contingent or otherwise, as principal or surety or otherwise) in respect
of  borrowed  money or any  Derivative  Transaction  other  than  any  Specified
Transaction.

         "THRESHOLD AMOUNT"  means

         (i)      with respect to Party A, 2% of "Total Capital and Reserves" of
                  Swiss  Bank  Corporation  as shown on the most  recent  annual
                  audited financial statements of Swiss Bank Corporation and

         (ii)     with respect to Party B, U.S. Dollars 10mm.

(d)      The "CREDIT EVENT UPON MERGER" provisions of Section 5 (b)(iv) will not
apply to either Party A or Party B.

(e)      The "AUTOMATIC EARLY  TERMINATION"  provision of Section 6 (a) will not
apply to Party A or Party B.

(f)      "PAYMENTS  ON EARLY  TERMINATION".  For the purpose of Section 6 (e) of
this Agreement:

         (i)      Market Quotation will apply.

         (ii)     The Second Method will apply.

(g)      "TERMINATION CURRENCY" means United States Dollars.

(h)      "ADDITIONAL TERMINATION EVENT" will not apply.


                                     PART 2
                               TAX REPRESENTATIONS


(a)      Payer  Representation.   For  the  purpose  of  Section  3(e)  of  this
Agreement,  Party A will make the following representation and Party B will make
the following representation:-

                  It is not required by any  applicable  law, as modified by the
         practice  of  any  relevant  governmental  revenue  authority,  of  any
         Relevant  Jurisdiction  to make any deduction or withholding  for or on
         account of any Tax from any payment  (other than interest under Section
         2(e),  6 (d) (ii) or 6 (e) of this  Agreement)  to be made by it to the
         other party under this Agreement. In making this representation, it may
         rely on (i) the accuracy of any representations made by the other party
         pursuant to Section 3 (f) of this Agreement,  (ii) the  satisfaction of
         the agreement contained in Section 4 (a)(iii) of this Agreement and the
         accuracy and  effectiveness of any document provided by the other party
         pursuant to Section 4 (a)(i) or 4 (a)(iii) of this  Agreement and (iii)
         the  satisfaction  of the  agreement  of the other party  contained  in
         Section 4 (d) of this Agreement, provided that it shall not be a breach
         of this representation  where reliance is placed on clause (ii) and the
         other  party  does not  deliver  a form or  document  under  Section  4
         (a)(iii) by reason of  material  prejudice  to its legal or  commercial
         position.

(b)      Payee  Representations.  For  the  purpose  of  Section  3 (f) of  this
Agreement, Party A makes the following representation:


                                        2





        Each payment  received or to be received by it in  connection  with this
        Agreement will be  effectively  connected with its conduct of a trade or
        business in the United States of America.


                                     PART 3
                         AGREEMENT TO DELIVER DOCUMENTS

        For the purpose of Sections  4(a) (i) and (ii) of this  Agreement,  each
        party agrees to deliver the following documents, as applicable:

        (a)  Tax forms, documents or certificates to be delivered are:

PARTY REQUIRED TO
DELIVER DOCUMENT    FORM/DOCUMENT/CERTIFICATE     DATE BY WHICH TO BE DELIVERED

Party A             Department of the Treasury    On or before execution of this
                    Internal Revenue Service      Agreement and on an annual 
                    Form 4224                     basis thereafter              
                                                   

Party B             Department of the Treasury    On or before execution of this
                    Internal Revenue Service      Agreement                     
                    Form W-9                      
                   

        (b)  Other documents to be delivered are:


PARTY REQUIRED                                                    COVERED BY    
TO DELIVER                                    DATE BY WHICH TO    SECTION 3(D)  
DOCUMENT         FORM/DOCUMENT/CERTIFICATE    BE DELIVERED        REPRESENTATION
                                                                      
Party A and      Signature authentication     On or before        YES
Party B          satisfactory to the          execution of            
                 other party hereto           this Agreement
                                              

Party B          Copy (certified by an        On or before        YES
                 officer) of the board        execution of  
                 resolution (or equivalent    this Agreement
                 authorizing documentation)   
                 permitting the entering   
                 into of this Agreement    
                 and Transactions hereunder
                 

      

                                     PART 4
                                  MISCELLANEOUS

(a) ADDRESSES FOR NOTICES.  For the purposes of Section 12(a) of this Agreement:

         (i) All  notices  or  communications  to  Party A shall  be sent to the
         address, telex number, or facsimile number reflected below:

         Address:          Swiss Bank Corporation, London Branch
                           1 High Timber Street
                           London EC4V 3SB
         Attention:        Swaps Group
         Telex:            887434                    Answerback:  SBCO G
         Facsimile:        44-71-711-2364

                                        3


       

         (ii)  All  notices  or  communications  to Party B shall be sent to the
         address, telex number, or facsimile number reflected below:

         Address:          Interneuron Pharmaceuticals, Inc.
                           99 Hayden Avenue
                           Lexington, MA  02173
         Attention:        Thomas Farb, Executive Vice President, Finance
         Facsimile:        617-674-2448       Telephone No:  617-861-8444

(b)      PROCESS AGENT.  For the purpose of Section 13 (c) of this Agreement:

         Party A appoints as its Process Agent:  
                           Swiss Bank Corporation, New York Branch
                           222 Broadway, New York, NY 10038
                           Attention:  Legal Affairs

         Party B appoints as its Process Agent:    NOT APPLICABLE

(c)  OFFICES. The provisions of Section 10(a) will apply to Party A and Party B,
it being the understanding of the parties that while obligations entered into by
an Office of a party  pursuant to this Agreement  constitute  obligations of the
company  (and not merely of such  Office),  each party  will,  in respect of any
Transaction and in the ordinary course of business, send payments and notices to
and receive payments and notices from the Office of the other party specified in
the Confirmation of such Transaction rather than any other office of such party.
A party (the "owed  party") may seek  payment  from the head office of the other
party (the "owing  party") with  respect to this  Agreement in the event that an
amount  payable to the owed party by the owing party  pursuant to this Agreement
(including any amount payable as a result of the occurrence or designation of an
Early Termination Date) has not been paid in full when due.

(d)  MULTIBRANCH  PARTY.  For the  purpose of  Section 10 (c) of this  Agreement
neither Party A nor Party B is a Multibranch Party.

(e)  CALCULATION  AGENT.  The  Calculation  Agent is Party A,  unless  otherwise
specified in a Confirmation in relation to the relevant Transaction.

(f)  CREDIT SUPPORT DOCUMENT. Details of any Credit Support Document:

     NONE

(g)  CREDIT SUPPORT PROVIDER.  Credit Support Provider means:

     NOT APPLICABLE

(h)  GOVERNING  LAW.  THIS  AGREEMENT  WILL  BE  GOVERNED  BY AND  CONSTRUED  IN
ACCORDANCE  WITH THE LAWS OF THE STATE OF NEW YORK (WITHOUT  REFERENCE TO CHOICE
OF LAW DOCTRINE).

(i)  NETTING OF PAYMENTS.  Subparagraph  (ii) of Section 2 (c) of this Agreement
will apply.

(j)  "AFFILIATE"  will  have  the  meaning  specified  in  Section  14  of  this
Agreement.


                                        4




                                     PART 5
                                OTHER PROVISIONS

(a)  SET-OFF.  Without  affecting the provisions of the Agreement  requiring the
calculation  of certain net payment  amounts,  all payments under this Agreement
will be made without set-off or counterclaim;  provided,  however, that upon the
designation of any Early  Termination Date, in addition to and not in limitation
of any other right or remedy (including any right to set off,  counterclaim,  or
otherwise withhold payment or any recourse to any Credit Support Document) under
applicable law the  Non-defaulting  Party or Non-affected Party (in either case,
"X") may  without  prior  notice  to any  person  set off any sum or  obligation
(whether or not arising under this  Agreement and whether  matured or unmatured,
whether or not contingent and irrespective of the currency,  place of payment or
booking  office  of the sum or  obligation)  owed  by the  Defaulting  Party  or
Affected Party (in either case,  "Y") to X or any Affiliate of X against any sum
or obligation  (whether or not arising under this Agreement,  whether matured or
unmatured,  whether or not contingent and irrespective of the currency, place of
payment or booking office of the sum or  obligation)  owed by X or any Affiliate
of X to Y and,  for this  purpose,  may convert one  currency  into another at a
market rate determined by X. If any sum or obligation is unascertained, X may in
good  faith  estimate  that sum or  obligation  and  set-off  in respect of that
estimate,  subject to X or Y, as the case may be,  accounting to the other party
when such sum or obligation is ascertained.

(b)  REPRESENTATIONS  AND  WARRANTIES.  Section  3(a) is  amended  by adding the
following paragraphs (vi) and (vii):

         "(vi)  NO  AGENCY.   It  is  entering  into  this  Agreement  and  each
         Transaction  as principal  (and not as agent or in any other  capacity,
         fiduciary or otherwise).

         (vii) ELIGIBLE SWAP  PARTICIPANT.  It is an "eligible swap participant"
         as that term is defined by the United States Commodity  Futures Trading
         Commission  in 17 C.F.R.  ss.  35.1(b)(2)  and it has entered into this
         Agreement and it is entering into each  Transaction in connection  with
         its line of business (including financial  intermediation  services) or
         the financing of its business; and the material terms of this Agreement
         and such Transaction have been individually tailored and negotiated."

(c)  RELATIONSHIP BETWEEN PARTIES. Each party will be deemed to represent to the
other party on the date on which it enters  into a  Transaction  that  (absent a
written  agreement  between  the  parties  that  expressly  imposes  affirmative
obligations to the contrary for that Transaction):

         (i) NON-RELIANCE. It is acting for its own account, and it has made its
         own  independent  decisions  to enter into that  Transaction  and as to
         whether that Transaction is appropriate or proper for it based upon its
         own  judgment  and upon  advice  from such  advisers  as it has  deemed
         necessary.  It is not relying on any communication (written or oral) of
         the other party as investment  advice or as a  recommendation  to enter
         into  that  Transaction;  it  being  understood  that  information  and
         explanations related to the terms and conditions of a Transaction shall
         not be considered  investment  advice or a recommendation to enter into
         that Transaction.  No communication (written or oral) received from the
         other party shall be deemed to be an  assurance  or guarantee as to the
         expected results of that Transaction.

         (ii)  ASSESSMENT  AND  UNDERSTANDING.  It is capable of  assessing  the
         merits of and understanding  (on its own behalf or through  independent
         professional advice), and understands and accepts the terms, conditions
         and risks of that  Transaction.  It is also  capable of  assuming,  and
         assumes, the risks of that Transaction.

         (iii) STATUS OF PARTIES.  The other party is not acting as a fiduciary 
         for or an adviser to it in respect of that Transaction.


                                        5




(d)  TRANSFER.  Section  7 is  amended  by the  deletion  of "and" at the end of
paragraph (a), the deletion of the full stop at the end of paragraph (b) and the
insertion of a semi-colon followed by "and" in its place, and the insertion of a
new paragraph  after  paragraph (b) at the end thereof "(c) Party A may transfer
its rights and  obligations  under this  Agreement in whole (but not in part) to
any branch of Swiss Bank Corporation provided that as a result of such transfer:

         (i)      it does not become  unlawful  for either  party to perform any
                  obligation under this Agreement;

         (ii)     neither  party  is  required  to  pay to the  other  party  an
                  additional  amount under  Section  2(d)(i)(4)  or to receive a
                  payment  from which an amount is  required  to be  deducted or
                  withheld for or on account of a Tax and no  additional  amount
                  is  required  to be paid in respect of such Tax under  Section
                  2(d)(i)(4); and

         (iii)    no Event of Default occurs in respect of either party."

(e)  WAIVER OF JURY  TRIAL.  Each party  hereby  irrevocably  waives any and all
right to trial by jury in any  suit,  action  or  proceeding  arising  out of or
relating to this Agreement or any Transaction and acknowledges  that this waiver
is a material inducement to the other party's entering into this Agreement.

(f)  CONSENT TO RECORDING. The parties agree that each may electronically record
all telephonic  conversations  between them and that any such  recordings may be
submitted  in  evidence  to any court or in any  Proceedings  for the purpose of
establishing any matters pertinent to any Transaction.

(g)  SEVERANCE. In the event any one or more of the provisions contained in this
Agreement should be held invalid,  illegal or unenforceable in any respect, such
provisions  shall  be  severed  from  this  Agreement  to  the  extent  of  such
invalidity,   illegality  or  unenforceability,   unless  such  severance  shall
substantially  impair the benefits of the remaining  portions of this Agreement.
The  Agreement  after  such  severance  shall  remain  the  valid,  binding  and
enforceable obligation of the parties hereto.

(h)  NETTING PROVISIONS. If an Early Termination Date occurs, amounts determined
in respect of all Terminated  Transactions  shall be aggregated  with and netted
against one another in performing the calculations contemplated by Section 6(e).
If the calculation of the amount payable  pursuant to Section 6(e) in respect of
an Early  Termination  Date would involve the  aggregation or netting of amounts
determined in respect of Transactions of different  types,  and under applicable
law amounts determined in respect of one or more types of Transactions hereunder
may not be aggregated  with or netted against  amounts  determined in respect of
one or more other types of Transactions in performing  such  calculation,  then,
notwithstanding  the  foregoing  or  any  other  provision  of  this  Agreement,
aggregation  and  netting  will  be  performed   within  and  between  types  of
Transactions  to  the  fullest  extent  permitted  by  law  in  performing  such
calculation,  and the set-off  provisions of this  Agreement and  applicable law
shall be applied to the resulting amount or amounts.

(i)  DEFINITIONS.  The following definition shall appear in Section 14 after the
definition of "Defaulting Party":

          "Derivative Transaction" means:

         (a)      any transaction  (including an agreement with respect thereto)
                  which is a rate swap  transaction,  basis swap,  forward  rate
                  transaction,  commodity  swap,  commodity  option,  equity  or
                  equity index swap, equity or equity index option, bond option,
                  interest rate option, foreign exchange transaction, repurchase
                  transaction,  reverse repurchase transaction,  precious metals
                  transaction,  cap  transaction,   floor  transaction,   collar
                  transaction,  currency swap transaction,  cross-currency  rate
                  swap


                                        6




                  transaction,  currency option or any other similar transaction
                  (including   any   option   with   respect  to  any  of  these
                  transactions); and

         (b)     any combination of these transactions."

(j)  ONE-WAY  TRANSACTION.  Party B agrees that in the event the  parties  enter
into a Transaction, other than a call option transaction written by either Party
A or Party B where the property  underlying the  transaction is the common stock
of Party B, then Party B will enter into a new Master  Agreement with Party A or
will amend this Agreement,  in either case in a form satisfactory to Party A and
Party B.



                                     PART 6
            ADDITIONAL TERMS FOR EQUITY AND EQUITY INDEX TRANSACTIONS

Notwithstanding  anything  to the  contrary  in this  Agreement,  the  following
provisions will apply for the purposes of any Transaction  which is an option on
a single security, a basket of securities or an index, including any Transaction
which  contemplates by its terms the physical delivery of shares,  participation
certificates or other equity securities ("Shares"):

(a)  DIVIDENDS  AND  EXPENSES.  The  following  provision  shall be  included as
Section 2(f):

         "(f) DIVIDENDS AND EXPENSES ON DELIVERY: All dividends on the Shares to
be  delivered  shall be  payable  to and all  costs  and  expenses  incurred  in
connection with the delivery of Shares (including,  without prejudice to Section
2(d),  any Tax or Stamp Tax and any interest or penalties  payable in connection
therewith)  shall be payable  by the party who would  customarily  receive  such
dividend or bear such costs or expenses under a contract for the purchase of the
Shares by the deliveree  through the clearance  system specified in the relevant
Confirmation."

(b)  REPRESENTATIONS.  Each party acknowledges that (i) certain Transactions may
be securities that have not been registered  under the Securities Act of 1933 of
the United States of America,  as amended (the "1933 Act"), or under the laws of
any state,  (ii) no federal or state agency has passed upon such Transactions or
made any finding or  determination  as to the fairness of such  Transactions and
(iii) such  Transactions are intended to be exempt from  registration  under the
1933 Act. In addition to the representations  made pursuant to Section 3 of this
Agreement,each  party  represents  to the other  party with  respect to any such
Transaction that (i) it is an "accredited  investor," as such term is defined in
Regulation  D  promulgated  under the 1933 Act,  (ii) it has had  access to such
information  regarding  such  Transaction  and the other party as it  requested,
(iii) it has knowledge and  experience in financial and business  matters and is
capable of evaluating  the merits and risks of such  Transaction  and is able to
bear the economic risk of its investment,  including without limitation the risk
of  complete  loss on the  investment,  (iv) it  acquired  its  interest in such
Transaction  for its own  account for  investment  and not with a view to, or in
connection  with,  any  distribution  of such  interests,  (v) it will not sell,
transfer,  assign or otherwise  dispose such Transaction or interests herein and
therein in violation of the 1933 Act and the rules and  regulations  promulgated
thereunder,  and (vi) with respect to any Transaction which  contemplates by its
terms the physical  delivery of Shares,  at the time of the delivery of any such
Shares to the other party, it possesses full legal and beneficial  title thereto
and it is delivering the same free and clear of any lien, claim,  encumbrance or
security interest of any kind whatsoever created by the deliveror.


                                        7



                                                                Exhibit 10.90(a)
CONTRACT A-1

                                  CONFIRMATION


Date:                      May 12, 1997

To:                        Interneuron Pharmaceuticals, Inc. ("Party B")

Attention:                 Thomas F. Farb

From:                      Swiss Bank Corporation, London Branch ("Party A")

Re:                        Equity Option Confirmation
                           Reference Number ____________
- -----------------------------------------------------------------------

The purpose of this  communication is to confirm the terms and conditions of the
transaction  (the  "Transaction")  entered  into  between  us on the Trade  Date
specified below. This  Confirmation  constitutes a "Confirmation" as referred to
in the 1992 ISDA Master Agreement specified below.

The  definitions  and  provisions  contained  in the 1991 ISDA  Definitions  (as
published by the International Swaps and Derivatives Association, Inc. (formerly
known  as the  International  Swap  Dealers  Association,  Inc.)  ("ISDA"))  are
incorporated into this Confirmation.  In the event of any inconsistency  between
those definitions and provisions and this  Confirmation,  this Confirmation will
govern.

This Confirmation supplements, forms part of, and is subject to, the ISDA Master
Agreement dated as of May 5, 1997, as amended and supplemented from time to time
(the  "Agreement"),  between  you and Swiss  Bank  Corporation.  All  provisions
contained in the Agreement govern this Confirmation except as expressly modified
below.

The terms of the Transaction to which this Confirmation relates are as follows:

Trade Date                 :        May 9, 1997

Buyer                      :        Party B

Seller                     :        Party A

Option Style               :        European Option

Option Type                :        Capped Call

Shares                     :        Common Stock of Interneuron Pharmaceuticals,
                                    Inc. (Symbol: IPIC)

Number of Options          :        310,000

Contract Multiplier        :        1.00

Strike Price               :        USD 17.75

Cap Price                  :        USD 26.00

Total Premium              :        Call options written by Party B on shares of
                                    Party B's Common Stock.

Premium
Payment Date               :        May 9, 1997

Expiration Date            :        September  24, 1997, or, if that date is not
                                    an Exchange Business Day, the  following day
                                    that is an Exchange Business Day.







Currency
Business Day :             Any  day  on  which  commercial  banks  are  open for
                                    business   (including  dealings  in  foreign
                                    exchange and foreign  currency  deposits) in
                                    the cities from which and in which a payment
                                    is to be made.

Exchange
Business Day :             A day  that  is ( or  but for  the  occurrence  of  a
                                    Market Disruption Event,  would have been) a
                                    trading  day on the  Exchange  (other than a
                                    day on which trading on any such exchange is
                                    scheduled  to  close  prior  to its  regular
                                    weekday closing time, first announced on the
                                    day of such closing).

Normal
Trading Day                :        An Exchange  Business Day on which no Market
                                    Disruption   Event   has   occurred   or  is
                                    continuing.

Market
Disruption  Event          :        The  occurrence or existence on any Exchange
                                    Business Day during the one-half hour period
                                    that  ends at the close of  business  of any
                                    suspension  of  or  limitation   imposed  on
                                    trading  (by  reason of  movements  in price
                                    exceeding  levels  permitted by the relevant
                                    exchange or  otherwise),  provided  that any
                                    such  event is  material  in the  reasonable
                                    determination of the Calculation  Agent, and
                                    agreed to by Party B, on:  (i) the  Exchange
                                    in the  Shares;  or (ii) the  Pacific  Stock
                                    Exchange in options contracts on the Shares.

Exchange                   :        Nasdaq National Market

Clearance System
Business Day               :        Any day on which  the  Clearance  System  is
                                    open for the  acceptance  and  execution  of
                                    settlement instructions.

Clearance System           :        Depository  Trust  Company, or any successor
                                    to or transferee of such clearance system.

Calculation Agent          :        Party A, whose calculations shall be binding
                                    absent manifest error.

Procedure for Exercise
- ----------------------

Exercise Date     :        The Expiration Date.

Expiration Time   :        5:00 p.m. local time in New York City

Automatic  Exercise        :        The   Transaction   will  be  deemed  to  be
                                    automatically    exercised    if    it    is
                                    In-the-Money on the Expiration Date,  unless
                                    (i) the Buyer has notified the Seller or its
                                    agent (by telephone or in writing)  prior to
                                    5:00 p.m. local time in New York City on the
                                    Expiration  Date  that it does  not  wish to
                                    exercise the Transaction (or wishes to delay
                                    the Expiration Date, as set forth below); or
                                    (ii) the Closing  Value cannot be determined
                                    on the Expiration  Date. If the  Transaction
                                    is to be cash settled,  "In-the-Money" means
                                    that the Cash  Settlement  Amount is greater
                                    than  zero.  If  the  Transaction  is  to be
                                    physically  settled,   "In-the-Money"  means
                                    that the Closing  Value is greater  than the
                                    Strike  Price.  "Closing  Value"  means  the
                                    closing price of the Shares,  as reported on
                                    the Exchange, on the Expiration Date.

Telephone
and facsimile number
of Seller's Agent


                                       2







for purposes of
giving notice              :        Telephone:       (312) 554-5249
                                    Fax:             (312) 554-6271
                                    Attention:       David P. Stowell

Settlement Terms
- ----------------

Settlement                 :        The   Transaction   will  be  cash  settled;
                                    provided, however, that Party B may elect to
                                    physically  settle the Transaction by giving
                                    notice to Party A no later than ten Exchange
                                    Business Days before the Expiration Date.

Physical  Settlement       :        If  the  Transaction  is  to  be  physically
                                    settled,  on the Settlement Date, the Seller
                                    shall  deliver  to the Buyer  the  number of
                                    Shares  equal  to  the  Contract  Multiplier
                                    multiplied   by  the   number   of   Options
                                    exercised  against  payment  by the Buyer to
                                    the Seller of an amount equal to the product
                                    of  (a)  the  Strike   Price,   adjusted  as
                                    hereinafter provided,  multiplied by (b) the
                                    Contract  Multiplier  multiplied  by (c) the
                                    number of Options exercised.  If the Closing
                                    Value  exceeds  the Cap  Price,  the  Strike
                                    Price  shall be  increased  by the amount by
                                    which  the  Closing  Value  exceeds  the Cap
                                    Price;  if the Closing  Value is equal to or
                                    less than the Cap Price,  no adjustment will
                                    be made to the Strike  Price.  Such  payment
                                    and such  delivery  will be made through the
                                    Clearance  System at the accounts  specified
                                    below, on a delivery versus payment basis.

Cash  Settlement           :        If the Transaction is to be cash settled, on
                                    the  Settlement  Date,  Party A shall pay to
                                    Party B the Cash Settlement  Amount, if any.
                                    The "Cash  Settlement  Amount"  shall be the
                                    greater  of  (a)  zero  and  (b)  an  amount
                                    calculated by the Calculation Agent equal to
                                    (i) the Contract  Multiplier  multiplied  by
                                    (ii)  the   number  of   Options   exercised
                                    multiplied by (iii) the Price  Differential.
                                    "Price   Differential"   means  (x)  if  the
                                    Reference  Price exceeds the Cap Price,  the
                                    result of subtracting  the Strike Price from
                                    the  Cap  Price,  and  (y) if the  Reference
                                    Price  is  equal  to or  less  than  the Cap
                                    Price,  the result of subtracting the Strike
                                    Price from the Reference Price.

Reference Price            :        (a) If the  Valuation  Period  contains five
                                    Normal  Trading Days,  the  Reference  Price
                                    shall be the arithmetic average of the Share
                                    Prices on those five Normal Trading Days.

                                    (b) If the Valuation Period does not contain
                                    five Normal Trading Days,  Party A and Party
                                    B, shall  jointly  determine the Share Price
                                    for the Valuation  Date and as many Exchange
                                    Business  Days  immediately   preceding  the
                                    Valuation  Date as shall be necessary,  when
                                    such Share  Prices are taken  together  with
                                    the Share Prices on all Normal  Trading Days
                                    occurring  within the Valuation  Period,  to
                                    provide five Share Prices,  and in such case
                                    the Reference  Price shall be the arithmetic
                                    average of those five Share Prices.

Share Price                :        The  volume  weighted  average  price of the
                                    Shares  as  reported  on  Bloomberg  for the
                                    period  from  9:30 a.m.  to 4:30 p.m.  local
                                    time in New York City on the given day.

Valuation  Period          :        The  period  from and  including  the fourth
                                    Exchange Business Day immediately  preceding
                                    the Expiration  Date (the "Initial Date") to
                                    and including the Expiration Date,  provided
                                    that  if any  Exchange  Business  Day in the
                                    Valuation Period as so determined, shall not
                                    be  a  Normal  Trading  Day,  the  Valuation
                                    Period   shall  be   extended  so  that  the


                                       3







                                    Valuation   Period   includes   five  Normal
                                    Trading  Days , but in no  event  shall  the
                                    last day of the  Valuation  Period  be later
                                    than the fifth  Exchange  Business Day after
                                    the  Expiration  Date, and in no event shall
                                    the Valuation  Period include any day before
                                    the Initial Date.

Valuation Date             :        The last day of the Valuation Period.

Settlement Date            :        If the  Transaction  is to be cash  settled,
                                    the Settlement  Date shall be three Currency
                                    Business Days after the  Valuation  Date. If
                                    the Transaction is to be physically settled,
                                    the Settlement Date shall be three Clearance
                                    System  Business  Days  after  the  Exercise
                                    Date.

Change in Expiration Date
- -------------------------

Delay or Acceleration
of Expiration Date         :        At any time prior to the day that  otherwise
                                    would have been the  Initial  Date,  Party B
                                    may  notify  Party A that it  would  like to
                                    delay or accelerate the Expiration  Date, as
                                    of a date (the "Termination  Date") not less
                                    than ten  Exchange  Business  Days after the
                                    date  such  notice,  and,  in the  case of a
                                    delay,  not more  than 180  days  after  the
                                    Expiration  Date.  Promptly after receipt of
                                    such notice, Party A shall notify Party B of
                                    the additional  amount,  if any, required to
                                    be paid (the "Settlement Amount") (i) in the
                                    case of a delay of the  Expiration  Date, by
                                    the Buyer of the  Transaction  to compensate
                                    the  Seller  of  the  Transaction  for  such
                                    delay,   or   (ii)   in  the   case   of  an
                                    acceleration of the Expiration  Date, by the
                                    Seller of the  Transaction to compensate the
                                    Buyer   of   the    Transaction   for   such
                                    acceleration. The Settlement Amount shall be
                                    reasonably  determined  by  SBC  based  upon
                                    SBC's then current  methodology  for pricing
                                    options.  Within five Exchange Business Days
                                    after  receipt  of notice of the  Settlement
                                    Amount  from Party A,  Party B shall  notify
                                    Party A whether it agrees to the  Settlement
                                    Amount  (the  date  of  such   notice,   the
                                    "Agreement  Date"). If Party B agrees to the
                                    Settlement  Amount (i) the Termination  Date
                                    shall be  deemed to be the  Expiration  Date
                                    for all purposes of this  Confirmation;  and
                                    (ii) the Settlement  Amount,  which shall be
                                    in addition to any payment or  delivery,  if
                                    any, otherwise required to be made under the
                                    terms of the  Transaction,  shall be paid by
                                    the appropriate  party on the third Currency
                                    Business Day after the  Agreement  Date.  If
                                    Party B does  not  agree  to the  Settlement
                                    Amount,  the  Expiration  Date  shall not be
                                    delayed or accelerated, as the case may be.

Adjustment Events
- -----------------

Adjustments               :         During the life of the  Transaction,  if any
                                    adjustment  is made by The Options  Clearing
                                    Corporation or its successors ("OCC") in the
                                    terms  of  outstanding   OCC-issued  options
                                    ("OCC  Options") on the Shares which are the
                                    subject of the  Transactions,  an equivalent
                                    adjustment shall be made in the terms of the
                                    Transaction.   Except  as  provided  in  the
                                    following  paragraph and in the  "Additional
                                    Adjustment  Provisions" below, no adjustment
                                    shall   be   made  in  the   terms   of  the
                                    Transaction  for any  event  that  does  not
                                    result  in an  adjustment  to the  terms  of
                                    outstanding   OCC  Options  on  the  Shares.
                                    Without   limiting  the  generality  of  the
                                    foregoing,  NO  ADJUSTMENT  SHALL BE MADE IN
                                    THE TERMS OF THE  TRANSACTIONS  FOR ORDINARY
                                    CASH  DIVIDENDS  ON  THE  SHARES  EXCEPT  AS
                                    PROVIDED  IN  THE   "ADDITIONAL   ADJUSTMENT
                                    PROVISIONS" BELOW.


                                       4








                                    If at  any  time  during  the  life  of  the
                                    Transaction  there  shall be no  outstanding
                                    OCC  Options  on the  Shares,  and an  event
                                    shall  occur for which an  adjustment  might
                                    otherwise be made under the By-Laws,  Rules,
                                    and stated policies of the OCC applicable to
                                    the  adjustment  of OCC  Options  (the  "OCC
                                    Adjustment  Rules"),  the parties  shall use
                                    their best efforts,  applying the principles
                                    set forth in the OCC  Adjustment  Rules,  to
                                    jointly  determine  whether  to  adjust  the
                                    terms of the  Transaction  and the nature of
                                    any such adjustment.



Additional
Adjustments               :         Notwithstanding  the foregoing,  if upon the
                                    occurrence  of the  following  events during
                                    the life of the Transaction no adjustment is
                                    required  to be  made  to the  terms  of the
                                    Transaction in accordance with the foregoing
                                    provisions or if an adjustment has been made
                                    but such  adjustment  is, in the  reasonable
                                    determination  of the Calculation  Agent, in
                                    consultation  with Party B,  insufficient to
                                    preserve   the   economic   benefit  of  the
                                    Transaction  for the parties,  the following
                                    additional  adjustments shall be made to the
                                    terms of the Transaction:

                                    (a) If  (i) an  ordinary  cash  dividend  is
                                    declared  or  paid on the  Shares  or (ii) a
                                    special cash dividend is declared or paid on
                                    the   Shares   and  in   either   case   the
                                    Ex-Dividend   Date  with   respect  to  such
                                    dividend  occurs during the period from, and
                                    including,   the  Effective   Date  to,  but
                                    excluding,  the  Expiration  Date  (each,  a
                                    "Dividend Event"),  the Strike Price and the
                                    Contract  Multiplier  shall each be adjusted
                                    for each Dividend  Event in accordance  with
                                    the following formulas:

                                                             SP0 (CP0 - DA)
                                                  SP1    = ------------------  
                                                                  CP0

                                                                SP0
                                                  CM1    = --------------     
                                                                SP1

                                                  Where:

                                    (i)     SP1  =  Strike   Price   after   the
                                                    Dividend Event

                                    (ii)    CM1  = Contract Multiplier after the
                                                   Dividend Event

                                    (iii)   SP0 = Strike  Price on the  Exchange
                                                  Business    Day    immediately
                                                  preceding the Ex-Dividend Date
                                                  with  respect to the  Dividend
                                                  Event

                                    (iv)    CP0 = The   closing  price   of  the
                                                  Shares,  as  reported  on  the
                                                  Exchange,   on  the   Exchange
                                                  Business    Day    immediately
                                                  preceding the Ex-Dividend Date
                                                  with  respect to the  Dividend
                                                  Event

                                    (vi)    DA  = The  amount  of  the  ordinary
                                                  cash  dividend  or the special
                                                  cash dividend, as the case may
                                                  be

                                    (b) If there occurs a tender  offer,  by the
                                    issuer of the  Shares  (the  "Issuer")  or a
                                    third party, for the Shares, and the date of
                                    the    expiration   of   such   offer   (the
                                    "Termination Date") occurs during the period
                                    from, and including,  the Effective Date to,
                                    but  excluding,   the  Expiration  Date  (an
                                    

                                       5





                                    "Adjustment  Event"),  the Strike  Price and
                                    the  Contract   Multiplier   shall  each  be
                                    adjusted  for  each   Adjustment   Event  in
                                    accordance with the following formulas:

                                                             (CP0  x N0)  - C
                                                           --------------------
                                            SP1 =  SP0  x  [ CP0 x (N0  - N1) ]

                                                    SP0
                                            CM1 =  -----
                                                    SP1

                                            Where:

                                    (i)   SP1 =  Strike    Price    after    the
                                                 Adjustment Event

                                    (ii)  CM1 =  Contract  Multiplier  after the
                                                 Adjustment Event

                                    (iii) SP0 =  Strike Price on the  Completion
                                                 Date (as hereinafter defined)

                                    (iv)  CP0 =  The   closing   price   of  the
                                                 Shares,   as  reported  on  the
                                                 Exchange,   on  the  Completion
                                                 Date

                                    (v)   N0  =  Total   number   of  shares  of
                                                 common   stock  of  the  Issuer
                                                 outstanding  on the  Completion
                                                 Date

                                    (vi)  C   =  Price paid by the  offeror  per
                                                 share  of  common  stock of the
                                                 Issuer  multiplied by the total
                                                 number of shares  purchased  by
                                                 the  offeror  pursuant  to  the
                                                 Adjustment Event

                                    (vii) N1  =  Total   number   of  shares  of
                                                 common   stock  of  the  Issuer
                                                 purchased    by   the   offeror
                                                 pursuant   to  the   Adjustment
                                                 Event

                                    (viii) "Completion     Date"    means    the
                                           Termination Date; provided,  however,
                                           that  if  the  period  following  the
                                           Termination    Date   within    which
                                           delivery  of  tendered  shares may be
                                           guaranteed is less than the customary
                                           settlement  period  for a sale of the
                                           Shares executed through the Clearance
                                           System,  the Completion Date shall be
                                           the   date   which    precedes    the
                                           Termination  Date  by the  number  of
                                           Exchange  Business Days equal to such
                                           difference

Miscellaneous
Transfer                  :         Neither party may transfer the  Transaction,
                                    in  whole  or in  part,  without  the  prior
                                    written  consent  of  the   non-transferring
                                    party.

Account Details
- ---------------

Payments and deliveries to Party A:     Previously provided

Payments and deliveries to Party B:     Previously provided


                                       6






Please  confirm  that  the  foregoing  correctly  sets  forth  the  terms of our
agreement by executing the copy of this  Confirmation  enclosed for that purpose
and  returning  it to us or by  sending  to us a letter  or telex  substantially
similar to this letter,  which letter or telex sets forth the material  terms of
the Transaction to which this Confirmation  relates and indicates your agreement
to those terms.

Yours sincerely,

SWISS BANK CORPORATION, LONDON BRANCH


By: /s/ Stewart Macbeth                  By: /s/ Karen Hayes
   ----------------------------             ------------------------
Name: Stewart Macbeth                    Name: Karen Hayes
Title: Director Fx & Derivatives         Title: Associate Director 
                                                SCBW London


Confirmed as of the 12th day
of May, 1997

INTERNEURON PHARMACEUTICALS, INC.



By:  /s/ Thomas F. Farb
Name: Thomas F. Farb
Title: Executive Vice President - Finance


                                       7







                          Appendix to Exhibit 10.90(a)*


The Registrant  and Swiss Bank  Corporation,  London  Branch,  entered into four
transactions  evidenced  by four  confirmations,  relating  to an  aggregate  of
1,240,000  options,  each of which  is  substantially  identical  to the form of
confirmation  filed as  Exhibit  10.90(a),  except  that the Cap  Price  and the
Expiration Dates of the four confirmations are as follows:

                    Expiration Date              Cap Price

Contract A-1        September 24, 1997             $26.00
Contract A-2        March 9, 1998                  $34.00
Contract A-3        May 21, 1998                   $38.00
Contract A-4        August 24, 1998                $40.00


* Pursuant to Instruction 2 to Item 601 of Regulation S-K.
  




CONTRACT B-1
                                  CONFIRMATION


Date:                      May 12, 1997

To:                        Interneuron Pharmaceuticals, Inc. ("Party B")

Attention:                 Thomas F. Farb

From:                      Swiss Bank Corporation, London Branch ("Party A")

Re:                        Equity Option Confirmation
                           Reference Number___________________
- --------------------------------------------------------------------------------
The purpose of this  communication is to confirm the terms and conditions of the
transaction  (the  "Transaction")  entered  into  between  us on the Trade  Date
specified below. This  Confirmation  constitutes a "Confirmation" as referred to
in the 1992 ISDA Master Agreement specified below.

The  definitions  and  provisions  contained  in the 1991 ISDA  Definitions  (as
published by the International Swaps and Derivatives Association, Inc. (formerly
known  as the  International  Swap  Dealers  Association,  Inc.)  ("ISDA"))  are
incorporated into this Confirmation.  In the event of any inconsistency  between
those definitions and provisions and this  Confirmation,  this Confirmation will
govern.

This Confirmation supplements, forms part of, and is subject to, the ISDA Master
Agreement dated as of May 5, 1997, as amended and supplemented from time to time
(the  "Agreement"),  between  you and Swiss  Bank  Corporation.  All  provisions
contained in the Agreement govern this Confirmation except as expressly modified
below.

The terms of the Transaction to which this Confirmation relates are as follows:

Trade Date                 :        May 9, 1997

Buyer                      :        Party A

Seller                     :        Party B

Option Style               :        European Option

Option Type                :        Call

Shares            :        Common Stock of Interneuron Pharmaceuticals, Inc.  
                           (Symbol: IPIC)

Number of Options          :        1,000,000

Contract Multiplier        :        1.00

Strike Price               :        USD 40.30

Total Premium     :        Call options  written by  Party A on shares of  Party
                           B's Common Stock.

Premium
Payment Date      :        May 9, 1997

Expiration  Date  :        May 21,  1999,  or, if that  date is not an  Exchange
                           Business  Day, the  following day that is an Exchange
                           Business  Day;  provided,  however,  that if  Party B
                           elects to cash settle the  Transaction as hereinafter
                           provided,  the  Expiration  Date shall be extended to
                           the 35th Exchange Business Day after such date.

Currency









Business  Day    :         Any  day on  which  commercial  banks  are  open  for
                           business  (including dealings in foreign exchange and
                           foreign  currency  deposits) in the cities from which
                           and in which a payment is to be made.

Exchange
Business Day     :         A day that is (or but for the  occurrence of a Market
                           Disruption  Event,  would have been) a trading day on
                           the  Exchange  (other than a day on which  trading on
                           any such  exchange is scheduled to close prior to its
                           regular weekday closing time,  first announced on the
                           day of such closing).

Normal
Trading Day     :          An   Exchange   Business   Day  on  which  no  Market
                           Disruption Event has occurred or is continuing.

Market
Disruption Event  :        The occurrence or existence on any Exchange  Business
                           Day during the one-half  hour period that ends at the
                           close of business of any  suspension of or limitation
                           imposed on trading (by reason of  movements  in price
                           exceeding levels  permitted by the relevant  exchange
                           or  otherwise),  provided  that  any  such  event  is
                           material  in  the  reasonable  determination  of  the
                           Calculation  Agent, and agreed to by Party B, on: (i)
                           the Exchange in the Shares; or (ii) the Pacific Stock
                           Exchange in options contracts on the Shares.

Exchange          :        Nasdaq National Market

Clearance System
Business Day      :        Any day on which the Clearance System is open for the
                           acceptance and execution of settlement instructions.

Clearance System  :        Depository  Trust  Company,  or any  successor  to or
                           transferee of such clearance system.

Calculation Agent :        Party A, whose  calculations  shall be binding absent
                           manifest error.

Procedure for Exercise
- ----------------------

Exercise Date     :        The Expiration Date.

Expiration Time   :        5:00 p.m. local time in New York City

                           Automatic  Exercise : The Transaction  will be deemed
                           to be  automatically  exercised if it is In-the-Money
                           on the  Expiration  Date,  unless  (i) the  Buyer has
                           notified  the Seller  (by  telephone  or in  writing)
                           prior to 5:00 p.m. local time in New York City on the
                           Expiration Date that it does not wish to exercise the
                           Transaction (or wishes to delay the Expiration  Date,
                           as set forth below); or (ii) the Closing Value cannot
                           be  determined  on  the   Expiration   Date.  If  the
                           Transaction  is to  be  cash  settled  or  net  share
                           settled,   "In-the-Money"   means   that   the   Cash
                           Settlement  Amount  is  greater  than  zero.  If  the
                           Transaction    is   to   be    physically    settled,
                           "In-the-Money"   means  that  the  Closing  Value  is
                           greater than the Strike Price.  "Closing Value" means
                           the closing  price of the Shares,  as reported on the
                           Exchange, on the Expiration Date.

Seller's telephone
or facsimile number

                                       2






for purposes of
giving notice         :        Telephone:       (617) 861-8444 ext. 607
                                    Fax:             (617) 674-2448
                                    Attention:       Thomas F. Farb



Settlement Terms
- ----------------

Settlement            :    The Transaction will be physically settled; provided,
                           however, that Party B may elect to cash settle or net
                           share  settle  the  Transaction  by giving  notice to
                           Party A no  later  than  30  Exchange  Business  Days
                           before  the  Expiration  Date.   Notwithstanding  the
                           foregoing,  if on or  prior  to  the  fifth  Exchange
                           Business  Day  prior  to  the  Expiration  Date,  the
                           registration  statement referred to in Section 4.1 of
                           the  Agreement  Regarding   Registration  Rights  and
                           Related  Obligations (the  "Registration  Agreement")
                           attached   hereto  as   Exhibit  B  has  not   become
                           effective,  the Transaction  will be cash settled and
                           the parties shall have no further  obligations  under
                           the Registration Agreement.

Physical Settlement   :    If the Transaction is to be physically settled:

                           (a) at such time as Party B requests  but in no event
                           later  than 20  Exchange  Business  Days  before  the
                           Expiration  Date, Party A and Party B will enter into
                           the Registration Agreement attached hereto as Exhibit
                           I; and

                           (b) on the Settlement  Date, the Seller shall deliver
                           to the  Buyer  the  number  of  Shares  equal  to the
                           Contract  Multiplier  multiplied  by  the  number  of
                           Options exercised against payment by the Buyer to the
                           Seller of an amount  equal to the  product of (A) the
                           Strike   Price   multiplied   by  (B)  the   Contract
                           Multiplier  multiplied  by (C) the  number of Options
                           exercised.  Such  payment and such  delivery  will be
                           made  through the  Clearance  System at the  accounts
                           specified below, on a delivery versus payment basis.

Cash Settlement   :        If the Transaction is to be cash settled:

           (a)      within  one  Currency  Business  Day  after  written  notice
                           by  Party  A,  Party  B  will  pay  to  Party  A  the
                           Prepayment Amount.  The "Prepayment  Amount" shall be
                           an amount  calculated by the Calculation  Agent equal
                           to (i) the Contract Multiplier multiplied by (ii) the
                           number of Options to be exercised multiplied by (iii)
                           the result of  subtracting  the Strike Price from the
                           closing  price  of the  Shares,  as  reported  on the
                           Exchange, on the date of such notice by Party A.

           (b)      on the Settlement Date, the following payment shall be made:

                                 (i) if a  Prepayment  Amount  has been  paid by
                                 Party B, then (A) if the Final  Payment  Amount
                                 is a  positive  number,  Party B  shall  pay to
                                 Party A an amount  equal to the  Final  Payment
                                 Amount and (B) if the Final Payment Amount is a
                                 negative  number,  Party A shall pay to Party B
                                 an amount  equal to the  absolute  value of the
                                 Final  Payment   Amount.   The  "Final  Payment
                                 Amount"  shall be an amount,  which may be less
                                 than zero,  calculated by the Calculation Agent
                                 equal to (A) the Cash  Settlement  Amount minus
                                 (B)  the   Prepayment   Amount  minus  


                                       3






                                 (C) the Interest  Amount.  The "Cash Settlement
                                 Amount"  shall be the  greater  of (A) zero and
                                 (B) an  amount  calculated  by the  Calculation
                                 Agent  equal  to (1)  the  Contract  Multiplier
                                 multiplied   by  (2)  the   number  of  Options
                                 exercised  multiplied  by  (3)  the  result  of
                                 subtracting the Strike Price from the Reference
                                 Price. The "Interest Amount" shall be an amount
                                 calculated  by the  Calculation  Agent equal to
                                 the  aggregate  sum of the  amounts of interest
                                 calculated for each day in the period from (and
                                 including)  the date the  Prepayment  Amount is
                                 received  by  Party  A to (but  excluding)  the
                                 Settlement Date, determined as follows: (A) the
                                 Prepayment   Amount   multiplied   by  (B)  the
                                 overnight  Federal  Funds  Rate for such day as
                                 reported   in   Federal   Reserve   Publication
                                 H.15-519 divided by (C) 360.

                                 (ii) if a  Prepayment  Amount has not been paid
                                 by  Party B,  Party B shall  pay to Party A the
                                 Cash Settlement Amount, if any.

Reference Price   :        (a)  If  the  Valuation  Period  contains  35  Normal
                           Trading  Days,  the  Reference  Price  shall  be  the
                           arithmetic  average  of the Share  Prices on those 35
                           Normal Trading Days.

         (b) If the  Valuation  Period does not contain 35 Normal  Trading Days,
                           Party A and  Party B,  shall  jointly  determine  the
                           Share  Price  for  the  Valuation  Date  and as  many
                           Exchange  Business  Days  immediately  preceding  the
                           Valuation Date as shall be necessary, when such Share
                           Prices are taken  together  with the Share  Prices on
                           all  Normal   Trading  Days   occurring   within  the
                           Valuation Period, to provide 35 Share Prices,  and in
                           such case the Reference Price shall be the arithmetic
                           average of those 35 Share Prices.

Share Price      :         The volume  weighted  average  price of the Shares as
                           reported on  Bloomberg  for the period from 9:30 a.m.
                           to 4:30 p.m. local time in New York City on the given
                           day.

Valuation Period :         The  period  from and  including  the  34th  Exchange
                           Business Day  immediately  preceding  the  Expiration
                           Date  (the  "Initial  Date")  to  and  including  the
                           Expiration  Date,   provided  that  if  any  Exchange
                           Business   Day  in  the   Valuation   Period   as  so
                           determined,  shall not be a Normal  Trading  Day, the
                           Valuation  Period  shall  be  extended  so  that  the
                           Valuation Period includes 35 Normal Trading Days, but
                           in no  event  shall  the  last  day of the  Valuation
                           Period be later than the 35th  Exchange  Business Day
                           after the Expiration  Date, and in no event shall the
                           Valuation  Period  include any day before the Initial
                           Date.

Valuation Date    :   The last day of the Valuation Period.

Net Share
Settlement        :        If a Transaction is to be net share settled,

                           (a) no later than 20  Exchange  Business  Days before
                           the Expiration  Date,  Party A and Party B will enter
                           into the  Registration  Agreement  attached hereto as
                           Exhibit I; and

                (b) on the Settlement Date, Party B shall deliver to Party A the
                           number  of whole  Shares  (the  "Settlement  Shares")
                           equal to (i) the Cash  Settlement  Amount  divided by
                           (ii)  the  Closing  Value,  plus  cash in lieu of any
                           fractional  Shares.  If within 


                                       4






                           ten Exchange Business Days after the Settlement Date,
                           Party A resells all or any portion of the  Settlement
                           Shares and the net  proceeds  received by the Party A
                           upon resale of such Shares exceed the Cash Settlement
                           Amount (or if less than all of the Settlement  Shares
                           are resold,  the  applicable  pro rata portion of the
                           Cash  Settlement  Amount),  Party  A  shall  promptly
                           refund  in cash  such  difference  to Party B. In the
                           event that such net  proceeds  are less than the Cash
                           Settlement  Amount  (or  if  less  than  all  of  the
                           Settlement Shares are resold, the applicable pro rata
                           portion of the Cash Settlement Amount), Party B shall
                           pay in cash or additional Shares such difference (the
                           "Make-whole   Amount")  to  Party  A  promptly  after
                           receipt of notice thereof.  In the event that Party B
                           elects to pay the  Make-whole  Amount  in  additional
                           Shares,  Party B shall  deliver to Party A the number
                           of whole Shares (the  "Make-whole  Shares")  equal to
                           (i) the Make-whole Amount divided by (ii) the closing
                           price of the Shares as  reported  on the  Exchange on
                           the  Exchange  Business Day prior to delivery of such
                           Shares.  If within ten Exchange  Business  Days after
                           the  delivery  of the  Make-whole  Shares to Party A,
                           Party A resells all or any portion of such Shares and
                           the net  proceeds  received  by Party A exceed or are
                           less than the Make-whole  Amount (or if less than all
                           of the Make-whole  Shares are resold,  the applicable
                           pro  rata  portion  of the  Make-whole  Amount),  the
                           provisions set forth above with respect to payment of
                           the   Settlement   Payment   in   Shares,   including
                           Make-whole requirements, shall apply.

Settlement Date     :      If  the  Transaction  is  to  be  cash  settled,  the
                           Settlement Date shall be three Currency Business Days
                           after the Valuation Date. If the Transaction is to be
                           physically   settled  or  net  share   settled,   the
                           Settlement  Date  shall  be  three  Clearance  System
                           Business Days after the Exercise Date.

Change in Expiration Date
- -------------------------

Delay or Acceleration
of Expiration Date  :      At any time  prior to the day  that  otherwise  would
                           have been the Initial Date,  Party B may notify Party
                           A that it  would  like to  delay  or  accelerate  the
                           Expiration  Date,  as  of a  date  (the  "Termination
                           Date") not less than ten Exchange Business Days after
                           the date such  notice,  and,  in the case of a delay,
                           not more  than 180 days  after the  Expiration  Date.
                           Promptly after receipt of such notice,  Party A shall
                           notify  Party  B of the  additional  amount,  if any,
                           required to be paid (the "Settlement  Amount") (i) in
                           the case of a delay of the  Expiration  Date,  by the
                           Buyer of the  Transaction to compensate the Seller of
                           the  Transaction  for such delay, or (ii) in the case
                           of an  acceleration  of the  Expiration  Date, by the
                           Seller of the  Transaction to compensate the Buyer of
                           the Transaction for such acceleration. The Settlement
                           Amount  shall  be  reasonably  determined  by Party A
                           based upon  Party A's then  current  methodology  for
                           pricing options.  Within five Exchange  Business Days
                           after receipt of notice of the Settlement Amount from
                           Party A,  Party B shall  notify  Party A  whether  it
                           agrees  to the  Settlement  Amount  (the date of such
                           notice,  the "Agreement  Date"). If Party B agrees to
                           the Settlement  Amount (i) the Termination Date shall
                           be deemed to be the Expiration  Date for all purposes
                           of this Confirmation; and (ii) the Settlement Amount,
                           which   shall  be  in  addition  to  any  payment  or
                           delivery, if any, otherwise required to be made under
                           the  terms of the  Transaction,  shall be paid by the
                           appropriate  party on the third Currency Business Day
                           after the  Agreement  Date. If Party B does not agree
                           to the Settlement  Amount,  the Expiration Date shall
                           not be delayed or accelerated, as the case may 


                                       5





                           be.

Adjustment Events
- -----------------

Adjustments        :       During the life of the Transaction, if any adjustment
                           is made by The Options  Clearing  Corporation  or its
                           successors   ("OCC")  in  the  terms  of  outstanding
                           OCC-issued  options  ("OCC  Options")  on the  Shares
                           which  are  the  subject  of  the  Transactions,   an
                           equivalent  adjustment  shall be made in the terms of
                           the Transaction.  Except as provided in the following
                           paragraph   and   in   the   "Additional   Adjustment
                           Provisions" below, no adjustment shall be made in the
                           terms of the  Transaction for any event that does not
                           result in an adjustment  to the terms of  outstanding
                           OCC  Options  on the  Shares.  Without  limiting  the
                           generality of the foregoing,  NO ADJUSTMENT  SHALL BE
                           MADE IN THE TERMS OF THE  TRANSACTIONS  FOR  ORDINARY
                           CASH  DIVIDENDS  ON THE SHARES  EXCEPT AS PROVIDED IN
                           THE "ADDITIONAL ADJUSTMENT PROVISIONS" BELOW.

                           If at any time  during  the  life of the  Transaction
                           there  shall be no  outstanding  OCC  Options  on the
                           Shares,  and  an  event  shall  occur  for  which  an
                           adjustment might otherwise be made under the By-Laws,
                           Rules,  and stated  policies of the OCC applicable to
                           the  adjustment  of OCC Options (the "OCC  Adjustment
                           Rules"),  the parties  shall use their best  efforts,
                           applying  the   principles   set  forth  in  the  OCC
                           Adjustment  Rules,  to jointly  determine  whether to
                           adjust the terms of the Transaction and the nature of
                           any such adjustment.

Additional
Adjustments        :       Notwithstanding the foregoing, if upon the occurrence
                           of  the  following  events  during  the  life  of the
                           Transaction  no  adjustment is required to be made to
                           the terms of the  Transaction in accordance  with the
                           foregoing  provisions  or if an  adjustment  has been
                           made  but  such  adjustment  is,  in  the  reasonable
                           determination   of   the   Calculation    Agent,   in
                           consultation  with Party B,  insufficient to preserve
                           the  economic  benefit  of the  Transaction  for  the
                           parties, the following  additional  adjustments shall
                           be made to the terms of the Transaction:

                           (a) If (i) an ordinary  cash  dividend is declared or
                           paid on the Shares or (ii) a special cash dividend is
                           declared or paid on the Shares and in either case the
                           Ex-Dividend Date with respect to such dividend occurs
                           during the period from, and including,  the Effective
                           Date to, but excluding,  the Expiration Date (each, a
                           "Dividend Event"),  the Strike Price and the Contract
                           Multiplier  shall each be adjusted for each  Dividend
                           Event in accordance with the following formulas:

                                               SP0 (CP0 - DA)
                                   SP1    =  ------------------         
                                                    CP0

                                                 SP0
                                   CM1    =  ------------  
                                                 SP1

                                   Where:

                           (i)     SP1 = Strike Price after the Dividend Event

                           (ii)    CM1 = Contract Multiplier after the Dividend 
                                         Event

 
                                        6






                           (iii)   SP0 = Strike Price on the  Exchange  Business
                                         Day    immediately     preceding    the
                                         Ex-Dividend  Date with  respect  to the
                                         Dividend Event

                           (iv)    CP0 = The  closing  price of the  Shares,  as
                                         reported  on  the   Exchange,   on  the
                                         Exchange   Business   Day   immediately
                                         preceding  the  Ex-Dividend  Date  with
                                         respect to the Dividend Event

                           (vi)    DA =  The   amount  of  the   ordinary   cash
                                         dividend or the special cash  dividend,
                                         as the case may be

                           (b) If there occurs a tender offer,  by the issuer of
                           the Shares (the  "Issuer") or a third party,  for the
                           Shares,  and the date of the expiration of such offer
                           (the  "Termination  Date")  occurs  during the period
                           from,  and  including,  the  Effective  Date to,  but
                           excluding,   the  Expiration   Date  (an  "Adjustment
                           Event"), the Strike Price and the Contract Multiplier
                           shall each be adjusted for each  Adjustment  Event in
                           accordance with the following formulas:

                                                    (CP0  x N0)  - C
                                                  --------------------
                                  SP1  =  SP0  x  [ CP0 x (N0  - N1) ]

                                           SP0
                                  CM1  =  ----- 
                                           SP1

                                  Where:

                           (i)    SP1 = Strike Price after the Adjustment Event

                           (ii)   CM1 = Contract Multiplier after the Adjustment
                                        Event

                           (iii)  SP0 = Strike Price on the  Completion Date (as
                                        hereinafter defined)

                           (iv)   CP0 = The  closing  price  of the  Shares,  as
                                        reported   on  the   Exchange,   on  the
                                        Completion Date

                           (v)     N0 = Total  number of shares of common  stock
                                        of  the   Issuer   outstanding   on  the
                                        Completion Date

                           (vi)    C  = Price paid by the  offeror  per share of
                                        common stock of the Issuer multiplied by
                                        the total number of shares  purchased by
                                        the offeror  pursuant to the  Adjustment
                                        Event

                           (vii)   N1 = Total  number of shares of common  stock
                                        of the Issuer  purchased  by the offeror
                                        pursuant to the Adjustment Event

                           (viii)  "Completion Date" means the Termination Date;
                                   provided,   however,   that  if  the   period
                                   following the  Termination  Date within which
                                   delivery of tendered shares may be guaranteed
                                   is less than the customary  settlement period
                                   for a sale of the Shares executed through the
                                   Clearance  System,  the Completion Date shall
                                   be the date which  precedes  the  Termination
                                   Date by the number of Exchange  Business Days
                                   equal to such difference


                                       7




Miscellaneous
- -------------

Transfer           :       Neither party may transfer the Transaction,  in whole
                           or in part,  without the prior written consent of the
                           non-transferring party.

Account Details
- ---------------

Payments and deliveries to Party A:     Previously provided

Payments and deliveries to Party B:     Previously provided


                                       8






Please  confirm  that  the  foregoing  correctly  sets  forth  the  terms of our
agreement by executing the copy of this  Confirmation  enclosed for that purpose
and  returning  it to us or by  sending  to us a letter  or telex  substantially
similar to this letter,  which letter or telex sets forth the material  terms of
the Transaction to which this Confirmation  relates and indicates your agreement
to those terms.

Yours sincerely,

SWISS BANK CORPORATION, LONDON BRANCH


By: /s/ Stewart Macbeth                  By: /s/ Karen Hayes
   ----------------------------             ------------------------
Name: Stewart Macbeth                    Name: Karen Hayes
Title: Director Fx & Derivatives         Title: Associate Director 
                                                SCBW London


Confirmed as of the 12th day
of May, 1997

INTERNEURON PHARMACEUTICALS, INC.



By:  /s/ Thomas F. Farb
Name: Thomas F. Farb
Title: Executive Vice President - Finance



                                       9





                          Appendix to Exhibit 10.90(b)*


The  Registrant  and Swiss Bank  Corporation,  London  Branch  entered  into two
confirmations,  relating to an aggregate of 2,000,000  options each  relating to
1,000,000 options and substantially  identical to the form of confirmation filed
as Exhibit  10.90(b),  except  that the  Expiration  Dates are May 21,  1999 for
contract B-1 and May 24, 1999 for contract B-2.


* Pursuant to section 2 to Item 601 of regulation S-K.



                                                                              
                                                                   EXHIBIT 10.91



                               AGREEMENT REGARDING
                   REGISTRATION RIGHTS AND RELATED OBLIGATIONS

         This Agreement  Regarding  Registration  Rights and Related Obligations
(this  "Agreement")  is  entered  into this _____ day of  _____________,  199__,
between  Interneuron   Pharmaceuticals,   Inc.,  a  Delaware   corporation  (the
"Company"), and Swiss Bank Corporation,  a Swiss banking corporation,  acting by
and through its London Branch ("SBC").

         WHEREAS, on  _______________,  1997, the Company issued to SBC, and SBC
acquired from the Company,  the Call Warrant,  as defined in Section 1.1 hereof,
in  consideration  of a capped  call  option  issued  on that date by SBC to the
Company,  as well as the other  undertakings  and obligations of the Company set
forth in the Call Warrant; and

         WHEREAS,  pursuant to the terms and conditions of the Call Warrant,  on
____________,  199__ or such later date as is  established  pursuant to the Call
Warrant (the "Maturity  Date"),  SBC has the right to purchase from the Company,
and, upon exercise of that right by SBC, the Company has the obligation,  at its
election,  either (i) to sell to SBC, at the exercise  price provided for in the
Call  Warrant,  the number of shares of the Company's  common  stock,  par value
$.001 per share (the "Common  Stock"),  underlying  the Call Warrant  ("Physical
Settlement")  or (ii) to pay to SBC an amount of cash  calculated as provided in
the Call Warrant ("Cash Settlement"); and

         WHEREAS,  pursuant to the terms and conditions of the Call Warrant,  in
the event the Company elects to discharge its obligations thereunder by Physical
Settlement, the Company and SBC shall enter into this Agreement; and

         WHEREAS, the Company has elected to discharge its obligations under the
Call Warrant by Physical Settlement;

         NOW,  THEREFORE,  in  consideration of the foregoing and other good and
valuable consideration, the Company and SBC hereby agree as follows:


                              ARTICLE I DEFINITIONS

         For  purposes of this  Agreement,  the  following  terms shall have the
following meanings:







         1.1 Call  Warrant.  "Call  Warrant"  shall mean the warrant to purchase
Common Stock  issued by the Company to SBC pursuant to the terms and  conditions
of the Confirmation.

         1.2 Commission.  "Commission"  shall mean the United States  Securities
and Exchange Commission or any successor agency thereto.

         1.3 Confirmation.  "Confirmation"  shall mean the confirmation  setting
forth  the  terms of the  Call  Warrant,  together  with  the  Master  Agreement
incorporated therein, dated as of _________________.

         1.4  Exchange  Act.   "Exchange  Act"  shall  mean  the  United  States
Securities Exchange Act of 1934, as amended.

         1.5 Local Business Day.  "Local Business Day" shall mean a day on which
commercial banks are open for business  (including  dealings in foreign exchange
and foreign currency deposits) in New York, New York.

         1.6 Preliminary  Prospectus.  "Preliminary  Prospectus"  shall mean any
preliminary  prospectus,  including  all  documents  incorporated  by  reference
therein,  included in the  Registration  Statement or filed with the  Commission
pursuant to Rule 424(a) of the rules and regulations of the Commission under the
Securities  Act; any reference to any amendment or supplement to the Preliminary
Prospectus shall be deemed to include any documents filed under the Exchange Act
after the date of such  Preliminary  Prospectus  and  incorporated  by reference
therein;  and  any  reference  to  the  Preliminary  Prospectus  as  amended  or
supplemented shall be deemed to include the Preliminary Prospectus as amended or
supplemented  by any such documents  filed under the Exchange Act after the date
of such Preliminary Prospectus and incorporated by reference therein.

         1.7 Prospectus.  "Prospectus" shall mean any prospectus,  including all
documents  incorporated by reference  therein,  (i) included in the Registration
Statement as of the time that the Registration  Statement is declared  effective
or (ii) filed with the Commission in connection with the Registration  Statement
pursuant to Rule 424(b) of the rules and regulations of the Commission under the
Securities  Act; any reference to any amendment or supplement to the  Prospectus
shall be deemed to include any documents  filed under the Exchange Act after the
date of such Prospectus and incorporated by reference therein; and any reference
to the  Prospectus  as amended or  supplemented  shall be deemed to include  the
Prospectus  as amended or  supplemented  by any such  documents  filed under the
Exchange Act after the date of such  Prospectus  and  incorporated  by reference
therein.

         1.8  Registration  Statement.  "Registration  Statement"  shall  mean a
registration  statement on Form S-3 (or any  applicable  successor  form then in
effect;  provided that if, at the time a registration  statement is to be filed,
the Company is not eligible to use Form


                                        2






S-3 or applicable  successor form for a primary  offering by or on behalf of the
Company,  "Registration  Statement" shall mean a registration  statement on such
form as is then  available  to the  Company),  which  is to be  filed  with  the
Commission  pursuant to Section 4.1  hereof,  covering  the resale of the Shares
from time to time, including all exhibits thereto and all documents incorporated
by reference in the Prospectus  contained in such Registration  Statement at the
time it is  declared  effective,  each as amended  at the time the  Registration
Statement is declared effective.

         1.9  Securities  Act.  "Securities  Act" shall  mean the United  States
Securities Act of 1933, as amended.

         1.10 Shares.  "Shares"  shall mean the shares of Common Stock  issuable
upon exercise of the Call Warrant.

         1.11  Termination  Date.  "Termination  Date"  shall  mean  the  second
anniversary of the Maturity Date.


            ARTICLE II REPRESENTATIONS AND WARRANTIES OF THE COMPANY

         The Company  represents and warrants to SBC that the following are true
and correct as of the date hereof and as of the "Settlement  Date" (as that term
is defined in the Confirmation):

         2.1  Organization  and  Existence of the Company.  The Company has been
duly  incorporated  and is validly  existing as a  corporation  in good standing
under the laws of the State of Delaware, with power and authority (corporate and
other) to own its  properties  and conduct its business as described in the 1934
Act  Reports,  and has been  duly  qualified  as a foreign  corporation  for the
transaction  of business  and is in good  standing  under the laws of each other
jurisdiction in which the ownership or leasing of properties,  or the conduct of
its business requires such qualification, except to the extent the failure to be
so  qualified  would not have a material  adverse  effect on the Company and its
subsidiaries, taken as a whole; and each subsidiary of the Company has been duly
incorporated  and is validly  existing as a corporation  and is in good standing
under the laws of its jurisdiction of incorporation, except where the failure to
be so  would  not  have a  material  adverse  effect  on  the  Company  and  the
subsidiaries taken as a whole.

         2.2  Authorization  of  Transactions  and  Agreement.   The  execution,
delivery and  performance  of this  Agreement  have been duly  authorized by the
board of directors of the Company.  Assuming the due  execution  thereof by SBC,
this  Agreement  constitutes  the legal,  valid and  binding  obligation  of the
Company, enforceable against the Company in accordance with its terms (except as
such  enforceability  may  be  limited  by  applicable  bankruptcy,  insolvency,
reorganization,  moratorium or other laws of general application  relating to or
affecting enforcement of creditors' rights and the application of equitable


                                        3





principles in any action, legal or equitable,  and except as rights to indemnity
or contribution may be limited by applicable law). The Company has the corporate
power to execute and deliver this Agreement and to consummate  the  transactions
contemplated herein.

         2.3 Capitalization. (a) As of __________, 199__, the authorized capital
stock of the Company consists of (i) ___________ shares of Common Stock and (ii)
_________  shares of preferred  stock, par value $.001 per share (the "Preferred
Stock"). As of _______,  199__,  ______________ shares of Common Stock (of which
__________  shares are treasury  shares) and _________ shares of Preferred Stock
were issued and outstanding. In addition, as of __________, 199__, the following
shares of Common  Stock  were  reserved  for  issuance  upon  [SPECIFY  RESERVED
SHARES].

         (b) The  outstanding  shares of Common Stock have been duly and validly
authorized  and  issued  and are fully paid and  non-assessable.  The  Company's
stockholders  have no preemptive  rights with respect to the Shares.  All of the
issued  shares of capital  stock of each  subsidiary  of the  Company  that is a
"significant  subsidiary" (as defined in Rule 12b-2 under the Exchange Act) have
been duly and validly authorized and issued, are fully paid and  non-assessable,
and all such shares that are owned  directly  or  indirectly  by the Company are
owned free and clear of all liens,  encumbrances,  equities or claims, with such
exceptions  as  would  not  have a  material  adverse  effect  on the  Company's
ownership interest in a significant subsidiary.

         (c) The Shares have been duly authorized and, when issued and delivered
upon  exercise of the Call Warrant in accordance  with the terms and  conditions
thereof, will be validly issued, fully paid and nonassessable.

         2.4  SEC  Filings  and  Financial  Statements.   (a)  The  Company  has
heretofore  delivered to SBC copies of the  Company's  (i) Annual Report on Form
10-K for the fiscal year ended [THEN MOST RECENTLY ENDED FISCAL YEAR],  and (ii)
the proxy statement for its 199__ Annual Meeting of Stockholders,  in each case,
substantially   in  the  form  filed  by  the   Company   with  the   Commission
(collectively,  together  with any other reports  filed,  as of the date of this
Agreement,  by the Company under the Exchange Act and the rules and  regulations
of the  Commission  since [TWO YEARS  BEFORE  DATE IN CLAUSE (I)] (the "1934 Act
Reports").  All of the 1934 Act Reports have complied in all material  respects,
as of their  respective  filing dates,  with all applicable  requirements of the
Exchange  Act and the  related  rules and  regulations  thereunder.  As of their
respective  filing  dates,  none of the 1934 Act  Reports  contained  any untrue
statement of a material  fact or omitted to state a material fact required to be
stated therein or necessary to make the statements  therein, in the light of the
circumstances  under  which  they  were  made,  not  misleading.  Any  amending,
correcting or superseding statement made in any subsequent 1934 Act Report shall
be  effective  for this purpose only with respect to the period after the filing
of such subsequent 1934 Act Report.


                                        4





         (b) The audited consolidated financial statements and unaudited interim
financial  statements of the Company  contained or  incorporated by reference in
the Company's  1934 Act Reports have been prepared in accordance  with generally
accepted accounting  principles applied on a consistent basis and, together with
the notes thereto,  present fairly the  consolidated  financial  position of the
Company and its subsidiaries at the dates shown and the consolidated  results of
their operations, changes in stockholders' equity and cash flows for the periods
then ended.

         2.5 No  Material  Adverse  Change.  Neither  the Company nor any of its
significant  subsidiaries  has  sustained  since the date of the latest  audited
financial  statements  included or  incorporated  by  reference  in the 1934 Act
Reports  any  material  loss  or  interference  with  its  business  from  fire,
explosion, flood or other calamity, whether or not covered by insurance, or from
any labor dispute or court or governmental  action,  order or decree,  otherwise
than as set forth or contemplated in the 1934 Act Reports. Since the date of the
latest audited financial statements included or incorporated by reference in the
1934 Act Reports, and except as may be set forth or contemplated in the 1934 Act
Reports,  there has not been (i) any material change in the capital stock of the
Company  (other than a change solely  attributable  to, or resulting  from,  the
issuance  of Common  Stock  pursuant to a  director,  officer or employee  stock
option,  benefit  or  compensation  plan),  (ii) any  material  increase  in the
short-term or long-term  consolidated  debt of the Company and its  consolidated
subsidiaries on a consolidated  basis or (iii) any material  adverse change,  or
any development  involving a prospective material adverse change, in the general
affairs,  management,  financial  position,  stockholders'  equity or results of
operations  of the Company and its  subsidiaries,  taken as a whole,  that could
reasonably  be expected to require  disclosure in a primary  public  offering of
Common Stock by the Company under the Securities Act.

         2.6 No Conflicts.  The execution and delivery of this Agreement and the
consummation of the transactions  herein  contemplated will not conflict with or
result  in a breach  or  violation  of any of the  terms or  provisions  of,  or
constitute  a  default   under,   any  indenture,   mortgage,   deed  of  trust,
sale/leaseback  agreement,  loan  agreement,   similar  financing  agreement  or
instrument  or other  agreement or instrument to which the Company or any of its
significant  subsidiaries  is a party  or by  which  the  Company  or any of its
significant  subsidiaries  is bound or to which any of the property or assets of
the Company or any of its significant  subsidiaries is subject,  except for such
conflicts, breaches or violations as would not have a material adverse effect on
the  Company  and its  subsidiaries,  taken as a whole,  or on the  transactions
contemplated by this Agreement or the Confirmation; nor will such actions result
in any  violation of the  provisions  of the  Certificate  of  Incorporation  or
by-laws of the  Company or any statute  applicable  to the Company or any of its
significant subsidiaries or any order, judgment, decree, rule or


                                        5





regulation  applicable to the Company or any of its significant  subsidiaries of
any court or governmental agency or body having jurisdiction over the Company or
any of its significant subsidiaries or any of their properties;  and no consent,
approval,  authorization,  order,  registration or  qualification of or with any
such court or  governmental  agency or body is required for the  consummation by
the Company of the transactions  contemplated by this Agreement,  except such as
may be required  under the  Securities Act prior to the resale of Shares and any
such consents, approvals, authorizations, registrations or qualifications as may
be  required  under state  securities  or Blue Sky laws in  connection  with the
resale of Shares.

         2.7 Litigation. Other than as set forth or contemplated in the 1934 Act
Reports,  there are no legal or  governmental  proceedings  pending to which the
Company or any of its  subsidiaries  is a party or of which any  property of the
Company or any of its subsidiaries is the subject which, if determined adversely
to  the  Company  or  any  of its  subsidiaries,  would  individually  or in the
aggregate have a material adverse effect on the consolidated financial position,
stockholders'   equity  or  results  of   operations  of  the  Company  and  its
subsidiaries; and to the Company's knowledge, no such proceedings are threatened
or contemplated by governmental authorities or threatened by others.

         2.8 Independence of Public Accountants. Coopers & Lybrand LLP, who have
audited  certain  financial  statements  of the  Company  and  its  consolidated
subsidiaries,  are independent  public accountants as required by the Securities
Act and  the  Exchange  Act and the  rules  and  regulations  of the  Commission
thereunder.

         2.9  Not an  Investment  Company.  The  Company  is not an  "investment
company" as such term is defined  under the  Investment  Company Act of 1940, as
amended.

         2.10 No  Registration  Rights.  Except as  provided  in  Schedule  2.10
hereto,  or in other  agreements with SBC, no person has any right to request or
demand to have any shares of Common  Stock or other  securities  of the  Company
registered  pursuant  to the  Registration  Statement  or  another  registration
statement pursuant to the Securities Act.

         2.11  Registrant  Requirements  for Form  S-3.  The  Company  meets the
registrant  requirements  of  General  Instruction  I.A.  of Form S-3  under the
Securities Act, as in effect on the date of this Agreement.

                ARTICLE III REPRESENTATIONS AND WARRANTIES OF SBC

         SBC  represents and warrants to the Company that the following are true
and correct as of the date hereof and as of the Settlement Date:


                                        6





         3.1  Organization  and  Existence of SBC. SBC is a banking  corporation
organized under the laws of Switzerland, with power and authority (corporate and
other) to own its properties and conduct its business.

         3.2  Authorization  of  Transactions  and  Agreement.   The  execution,
delivery and  performance of this  Agreement  have been duly  authorized by SBC.
Assuming the due execution  thereof by the Company,  this Agreement  constitutes
the legal,  valid and  binding  obligation  of SBC,  enforceable  against SBC in
accordance  with its terms  (except  as such  enforceability  may be  limited by
applicable bankruptcy, insolvency,  reorganization,  moratorium or other laws of
general  application  relating to or affecting  enforcement of creditors' rights
and the application of equitable  principles in any action,  legal or equitable,
and except as rights to indemnity or  contribution  may be limited by applicable
law).  SBC has the corporate  power to execute and deliver this Agreement and to
consummate the transactions contemplated herein.

         3.3 No Conflicts.  The execution and delivery of this Agreement and the
consummation of the transactions  herein  contemplated will not conflict with or
result  in a breach  or  violation  of any of the  terms or  provisions  of,  or
constitute a default under,  any agreement or instrument to which SBC is a party
or by which  SBC is bound or to which  any of the  property  or assets of SBC is
subject,  nor will such action result in any violation of the charter or by-laws
of SBC or any statute or any order, judgment,  decree, rule or regulation of any
court or governmental  agency or body having jurisdiction over SBC or any of its
properties,  except for such conflicts, breaches or violations as would not have
a material adverse effect on the transactions  contemplated by this Agreement or
the Confirmation; and no consent, approval,  authorization,  order, registration
or  qualification  of or with any such court or  governmental  agency or body is
required for the  consummation by SBC of the  transactions  contemplated by this
Agreement,  except such as may be required under the Securities Act prior to the
resale of Shares and any such consents, approvals, authorizations, registrations
or  qualifications as may be required under state securities or Blue Sky laws in
connection with the resale of Shares.


                      ARTICLE IV AGREEMENTS OF THE COMPANY

         The Company  agrees,  with respect to the period  beginning on the date
hereof through and including the earlier of the Termination  Date or the date on
which the Company  receives  written notice from SBC that all of the Shares have
been resold (except that the provisions of Section 4.9 may continue by its terms
after such date), as follows:

         4.1 Filing of  Registration  Statement.  (a) The  Company  has filed or
shall expeditiously file with the Commission a registration statement,  covering
the resale of the Shares from time to time by SBC and such  affiliated  entities
as SBC may designate on


                                        7





securities  exchanges or  over-the-counter or in such other lawful manner as SBC
may specify, in a form previously reviewed by SBC.

         (b) If such registration  statement has not yet become  effective,  the
Company  shall use its best  efforts to cause  such  registration  statement  to
become  effective no later than the Maturity Date. The Company shall (i) use its
best efforts to cause such registration  statement to remain in effect until the
earlier  of the  Termination  Date or the date on  which  the  Company  receives
written notice from SBC that all of the Shares have been resold, (ii) inform SBC
promptly upon notice from the  Commission  that the  Registration  Statement has
been declared effective,  (iii) advise SBC promptly of any proposed amendment or
supplement to the  Prospectus  after the effective  date thereof and furnish SBC
with a draft  prior to the filing  thereof,  (iv) for so long as  delivery  of a
prospectus  is required in  connection  with the  offering or sale of any of the
Shares, (A) unless the Company is legally required to so amend or supplement the
Prospectus, make no further amendment or any supplement to the Prospectus (other
than any such  amendment or supplement  resulting  from the filing of reports or
statements  under the  Exchange Act which are  incorporated  by reference in the
Prospectus)  after the effective  date thereof to which SBC  reasonably  objects
within two business days after  receipt of a draft of the proposed  amendment or
supplement  and (B)  file  promptly  all  reports  and any  definitive  proxy or
information  statements  required to be filed by the Company pursuant to Section
13(a),  13(c),  14 or 15(d) of the  Exchange  Act,  (v) during such same period,
advise SBC, promptly after the Company receives notice thereof,  (A) of the time
when any  amendment  to the  Registration  Statement  has been  filed or becomes
effective or any supplement to the Prospectus or any amended Prospectus has been
filed with the  Commission,  (B) of the issuance by the  Commission  of any stop
order  or of any  order  preventing  or  suspending  the  use of any  prospectus
relating to the Shares, (C) of the suspension of the qualification of the Shares
for offering or sale in any  jurisdiction,  (D) of the initiation or threatening
of any proceeding for any such purpose,  or (E) of any request by the Commission
for  the  amending  or  supplementing  of  the  Registration  Statement  or  the
Prospectus or for additional information,  and (vi) in the event of the issuance
of any such stop order or of any such order  preventing or suspending the use of
any prospectus relating to the Shares or suspending any such qualification,  use
promptly its best efforts to obtain the  withdrawal  of such order.  The Company
shall not include in the  Registration  Statement any securities  other than the
Shares.

         4.2  Qualification  of the Shares  under  State  Securities  Laws.  The
Company  shall  promptly  take,  from  time  to  time,  such  action  as SBC may
reasonably  request  to  qualify  the  Shares  for  offering  and sale under the
securities  laws of such of the United  States as SBC may  request and to comply
with such laws so as to permit the continuance of sales and dealings  therein in
such jurisdictions for as long as may be necessary to complete the resale of the
Shares (but not to exceed the period  specified  in the first  paragraph of this
Article IV);  provided that, in connection  therewith,  the Company shall not be
required to

                                        8





qualify  as a foreign  corporation  or to file a general  consent  to service of
process in any jurisdiction.

         4.3 Preparation of Registration  Statement;  Reasonable  Investigation.
The Company shall (a) give SBC, its designated affiliated entities,  counsel and
accountants   the   opportunity  to  participate  in  the   preparation  of  the
Registration  Statement  and,  to the  extent  practicable,  each  amendment  or
supplement thereto and document incorporated by reference therein which is filed
with the Commission after the filing of the Registration Statement, (b) give SBC
and its  representatives  such  reasonable  access  to the  books,  records  and
properties of the Company and its subsidiaries (to the extent  customarily given
to  those  who  are   underwriters   of  the  Company's   securities)  and  such
opportunities  to discuss the  business of the Company with its officers and the
independent public  accountants who have certified its financial  statements and
will have such  officers and  accountants  supply such  information  as shall be
reasonably  requested  by  SBC  or  its  representatives  in  connection  with a
"reasonable investigation" within the meaning of Section 11(b) of the Securities
Act and (c)  furnish  SBC with  copies  of any  press  release  or other  public
announcement  which it intends  to issue,  or any  report or  document  which it
intends to file under the Exchange Act with the  Commission or other  regulatory
agency,  insofar as such press  release,  public  announcement,  report or other
document   regards  this  Agreement  and  the  Call  Warrant   promptly   (where
practicable, at least two business days prior to the proposed issuance or filing
thereof),  and consider in good faith any comments  received from SBC concerning
the timing and content of such press  release,  public  announcement,  report or
other document.

         4.4 Compliance with Applicable Law and Commission Requirements. (a) The
Registration  Statement and Prospectus and all amendments or supplements thereto
shall conform in all material respects to the requirements of the Securities Act
and the rules and regulations of the Commission  thereunder and shall not, as of
the applicable effective date as to the Registration Statement and any amendment
thereto and as of the applicable filing date of the Prospectus and any amendment
or supplement thereto, contain an untrue statement of a material fact or omit to
state a material  fact  required to be stated  therein or  necessary in order to
make the statements made therein,  in the light of the circumstances under which
they were made, not misleading;  provided, however, that this covenant shall not
apply to any  statements  or omissions  made in reliance  upon and in conformity
with information furnished in writing to the Company by SBC expressly for use in
the Prospectus or any amendment or supplement thereto.

         (b) All of the documents  incorporated by reference in the Registration
Statement  and  Prospectus,  or any  amendment or  supplement  thereto,  whether
previously filed with the Commission or filed with the Commission  following the
date hereof,  at their respective  times of filing,  (i) shall have conformed or
shall conform,  as applicable,  in all material  respects to the requirements of
the  Securities  Act or the  Exchange  Act,  as  applicable,  and the  rules and
regulations of the Commission thereunder and (ii) shall not have contained


                                        9





or shall not contain,  as applicable,  an untrue statement of a material fact or
omit to state a material  fact  required to be stated  therein or  necessary  in
order to make the  statements  made therein,  in the light of the  circumstances
under  which  they were  made,  not  misleading;  provided,  however,  that this
representation  and warranty  shall not apply to (A) any statements or omissions
made in reliance upon and in conformity with information furnished in writing to
the Company by or on behalf of SBC  expressly  for use in the  Prospectus or any
amendment or supplement  thereto or (B)  statements or omissions  that have been
superseded or otherwise  corrected by an  amendment,  supplement or other filing
under  the  Exchange  Act  but  only  with  respect  to the  period  after  such
correction.

         4.5  Furnishing of  Prospectuses;  Notice to SBC of Need for Amendment.
The  Company  shall  furnish SBC with copies of the  Prospectus,  including  any
amendments or supplements  thereto,  in such  quantities as SBC may from time to
time reasonably request. If, while the Registration Statement is effective,  the
delivery of a prospectus is required at any time during the period  specified in
the first  paragraph of this Article IV in connection with the offering and sale
of the Shares by SBC and if, at such time,  any event  shall have  occurred as a
result of which the  Prospectus,  including  the  Prospectus  as then amended or
supplemented,  would  include an untrue  statement of a material fact or omit to
state any material fact  necessary in order to make the statements  therein,  in
the light of the  circumstances  under which they were made when such Prospectus
is delivered, not misleading,  or, if for any other reason it shall be necessary
during such same period to amend or supplement  the  Prospectus or to file under
the Exchange Act any document  incorporated  by reference in the  Prospectus  in
order to comply with the  Securities  Act or the Exchange Act, the Company shall
notify SBC in writing and, as promptly as  reasonably  possible,  provided  that
where such report is required  under this  Section 4.5 solely to comply with the
periodic  reporting  provisions  under the Exchange Act, such report need not be
filed sooner than required by such  provisions and no such written notice to SBC
shall be  required,  shall  amend or  supplement  the  Prospectus  or file  such
document so as to correct such  statement or omission or effect such  compliance
and shall  prepare and  furnish to SBC without  charge as many copies as SBC may
from time to time reasonably  request of any amended Prospectus or supplement to
the Prospectus.

         4.6 Listing of the Shares.  The Company  shall use its best  efforts to
have the Shares  approved for quotation on the Nasdaq  National Market or listed
on such other  exchange as the Company Common Stock is listed as of the Maturity
Date.

         4.7 Delivery of Opinion and Comfort  Letter.  On the effective  date of
the Registration  Statement,  the Company shall cause to be furnished to SBC (i)
an opinion or opinions of counsel for the Company, addressed to SBC and dated as
of the effective date of the Registration  Statement,  in substantially the form
of  Exhibit  A hereto,  and (ii) a letter  signed  by  Coopers  &  Lybrand  LLP,
addressed  to  SBC  and  dated  as of the  effective  date  of the  Registration
Statement, in substantially the form set forth in Exhibit B hereto, provided SBC
provides Coopers & Lybrand LLP with an appropriate request.


                                       10





         4.8  Furnishing  of  Additional  Information.  Until the earlier of the
Termination  Date or  completion  of resale of the  Shares,  the  Company  shall
furnish  to SBC  copies of all  reports or other  communications  (financial  or
other) generally  furnished to stockholders  and, as soon as they are available,
copies of any reports and  financial  statements  furnished to or filed with the
Commission or any national  securities exchange on which the Shares or any class
of  securities of the Company are listed (such  financial  statements to be on a
consolidated   basis  to  the  extent  the  accounts  of  the  Company  and  its
subsidiaries are consolidated in reports furnished to its stockholders generally
or to the Commission).

         4.9 Payment of Expenses.  The Company shall pay or cause to be paid the
following: (i) the fees, disbursements and expenses of the Company's counsel and
accountants  in  connection  with the  registration  of the Shares and all other
expenses  in  connection  with  the  preparation,  printing  and  filing  of the
Registration  Statement,  the  Prospectus  and any  amendments  and  supplements
thereto and the mailing and delivering of copies thereof, (ii) any fees incurred
in connection  with any stock exchange  listing or approval for quotation of the
Shares on the Nasdaq National Market,  (iii) all expenses in connection with the
qualification of the Shares for offering and sale under Section 4.2 hereof, (iv)
the cost of preparing  certificates for the Shares,  (v) the cost and charges of
any transfer agent or registrar or dividend disbursing agent, and (vi) all other
costs incident to the performance of the Company's  obligations under Article IV
hereof which are not otherwise  specifically provided for in this Section. It is
understood,  however,  that except as provided in this Section 4.9, SBC will pay
all of its own  costs  and  expenses,  including  the  fees of its  counsel  and
brokerage fees and commissions and transfer taxes on resale of any of the Shares
by SBC.


                           ARTICLE V AGREEMENTS OF SBC

         SBC agrees,  with  respect to the period  beginning  on the date hereof
through and including the Termination Date, as follows:

         5.1 Information  for Use in the Prospectus.  As soon as practicable but
in no event later than the third business day following the receipt of a written
request from the Company,  SBC shall  furnish the Company with such  information
regarding  SBC and its proposed  dispositions  of Shares as the Company may from
time to time reasonably request for use in preparing the Registration  Statement
and Prospectus, including any amendments or supplements thereto.

         5.2 Suspension of Disposition of Shares. Upon receipt of written notice
from the Company  pursuant to Section 4.5 that an event has occurred as a result
of which, or that the Company has discovered that, the Prospectus, including the
Prospectus as then amended or  supplemented,  includes an untrue  statement of a
material fact or omits to state any material fact necessary in order to make the
statements therein, in the light of the


                                       11





circumstances under which they were made, not misleading,  SBC shall immediately
discontinue  disposition of the Shares  pursuant to the  Registration  Statement
until such time as SBC shall have received  copies of an amended or supplemented
Prospectus  or until it receives  notice from the Company that  dispositions  of
Shares may be resumed without amendment or supplementation of the Prospectus.

         5.3 Notice of  Completion.  SBC shall  notify the Company  within three
business days of completion of its disposition of the Shares.

         5.4  Resales of Shares.  SBC agrees  that it will not offer,  transfer,
sell, pledge,  hypothecate or otherwise dispose of any of the Shares (or solicit
any  offers  to buy,  purchase  or  otherwise  acquire  or take a pledge  of any
Shares),  except  in  compliance  with  the  Securities  Act and the  rules  and
regulations  of the Commission  thereunder,  and in compliance  with  applicable
state securities or Blue Sky laws.


                           ARTICLE VI INDEMNIFICATION

         The Company and SBC further agree as follows:

         6.1 Indemnification with Respect to the Registration Statement. (a) The
Company will indemnify and hold harmless SBC against any losses, claims, damages
or liabilities,  joint or several,  to which SBC may become  subject,  under the
Securities Act, the Exchange Act or otherwise,  insofar as such losses,  claims,
damages or liabilities (or actions in respect thereof) arise out of or are based
upon an  untrue  statement  or  alleged  untrue  statement  of a  material  fact
contained in any Preliminary Prospectus,  any preliminary prospectus supplement,
the  Registration  Statement,  the  Prospectus  or any  amendment or  supplement
thereto,  or arise out of or are based upon the omission or alleged  omission to
state therein a material fact required to be stated therein or necessary to make
the  statements  therein,  in light of the  circumstances  under which they were
made,  not  misleading,  and will  reimburse SBC for any legal or other expenses
reasonably  incurred by SBC in connection  with  investigating  or defending any
such action or claim as such expenses are incurred;  provided, however, that the
Company  shall not be liable in any such case to the extent  that any such loss,
claim, damage or liability arises out of or is based upon an untrue statement or
alleged untrue statement or omission or alleged omission made in any Preliminary
Prospectus,  any supplement thereto, the Registration Statement,  the Prospectus
or any amendment or supplement  thereto in reliance upon and in conformity  with
written  information  furnished to the Company by or on behalf of SBC  expressly
for use therein.

         (b) SBC will  indemnify  and hold  harmless  the  Company  against  any
losses,  claims, damages or liabilities to which the Company may become subject,
under the Securities Act, the Exchange Act or otherwise, insofar as such losses,
claims, damages


                                       12




or liabilities (or actions in respect thereof) arise out of or are based upon an
untrue statement or alleged untrue statement of a material fact contained in any
Preliminary Prospectus,  any preliminary prospectus supplement, the Registration
Statement,  the Prospectus and any amendment or supplement thereto, or arise out
of or are  based  upon the  omission  or  alleged  omission  to state  therein a
material fact required to be stated  therein or necessary to make the statements
therein,  in  light  of the  circumstances  under  which  they  were  made,  not
misleading, in each case to the extent, but only to the extent, that such untrue
statement or alleged untrue  statement or omission or alleged  omission was made
in any  Preliminary  Prospectus,  any  preliminary  prospectus  supplement,  the
Registration Statement, the Prospectus or any amendment or supplement thereto in
reliance  upon and in  conformity  with  written  information  furnished  to the
Company by or on behalf of SBC expressly for use therein and will  reimburse the
Company for any legal or other  expenses  reasonably  incurred by the Company in
connection  with  investigating  or  defending  any such action or claim as such
expenses are incurred.

         (c) Promptly after receipt by an indemnified party under subsection (a)
or (b) above of notice of the commencement of any action, such indemnified party
shall,  if a claim in respect  thereof is to be made  against  the  indemnifying
party under such  subsection,  notify the  indemnifying  party in writing of the
commencement thereof; but the omission so to notify the indemnifying party shall
not relieve it from any  liability  which it may have to any  indemnified  party
otherwise than under such  subsection.  In case any such action shall be brought
against any indemnified party and it shall notify the indemnifying  party of the
commencement  thereof,  the indemnifying  party shall be entitled to participate
therein  and,  to the  extent  that  it  shall  wish,  jointly  with  any  other
indemnifying  party  similarly  notified,  to assume the defense  thereof,  with
counsel  satisfactory to such indemnified  party (who shall not, except with the
consent of the indemnified  party, be counsel to the indemnifying  party),  and,
after  notice  from  the  indemnifying  party to such  indemnified  party of its
election so to assume the defense thereof,  the indemnifying  party shall not be
liable to such indemnified party under such subsection for any legal expenses of
other counsel or any other expenses,  in each case subsequently incurred by such
indemnified  party, in connection with the defense thereof other than reasonable
costs of investigation.

         (d)  If  the  indemnification  provided  for  in  this  Section  6.1 is
unavailable  to or  insufficient  to hold  harmless an  indemnified  party under
subsection  (a) or (b)  above in  respect  of any  losses,  claims,  damages  or
liabilities  (or actions in respect  thereof)  referred  to  therein,  then each
indemnifying  party  shall  contribute  to the  amount  paid or  payable by such
indemnified party as a result of such losses, claims, damages or liabilities (or
actions in respect  thereof) in such proportion as is appropriate to reflect the
relative fault of the Company on the one hand and SBC on the other in connection
with the statements or omissions which resulted in such losses,  claims, damages
or liabilities  (or actions in respect  thereof),  as well as any other relevant
equitable  considerations.  The relative  fault shall be determined by reference
to,  among other  things,  whether the untrue or alleged  untrue  statement of a
material fact or the omission or alleged omission to state a material


                                       13




fact  relates to  information  supplied by the Company on the one hand or SBC on
the other and the parties' relative intent, knowledge, access to information and
opportunity  to correct or prevent such  statement or omission.  The Company and
SBC agree that it would not be just and  equitable if  contribution  pursuant to
this  subsection  (d) were  determined  by pro rata  allocation  or by any other
method of allocation which does not take account of the equitable considerations
referred  to above in this  subsection  (d).  The  amount  paid or payable by an
indemnified party as a result of the losses,  claims, damages or liabilities (or
actions in respect  thereof)  referred to above in this  subsection (d) shall be
deemed  to  include  any legal or other  expenses  reasonably  incurred  by such
indemnified party in connection with  investigating or defending any such action
or claim. No person guilty of fraudulent  misrepresentation  (within the meaning
of Section 11(f) of the Securities Act) shall be entitled to  contribution  from
any person who was not guilty of such fraudulent misrepresentation.

         (e) The  obligations  of the Company under this Section 6.1 shall be in
addition to any liability which the Company may otherwise have and shall extend,
upon the same terms and  conditions,  to each  "affiliate" (as defined under the
Securities  Act) of SBC,  to each  director  and each  officer of SBC and of its
affiliates,  to each person,  if any, who controls SBC or any of its  affiliates
within the meaning of the Securities  Act; and the obligations of SBC under this
Section 6.1 shall be in addition to any liability  which SBC may otherwise  have
and shall  extend,  upon the same  terms and  conditions,  to each  officer  and
director of the Company and to each  person,  if any,  who  controls the Company
within the meaning of the Securities Act.


                               ARTICLE VII GENERAL

         7.1 Notices.  (a) Any notice or other  communication in respect of this
Agreement  may be given in any manner set forth  below to the  address or number
specified in paragraph  (b) of this Section 7.1 and will be deemed  effective as
indicated:  (i) if in writing and delivered in person or by courier, on the date
it is  delivered;  (ii) if sent by  facsimile  transmission,  on the  date  that
transmission  is received by a responsible  employee of the recipient in legible
form (it being  agreed that the burden of proving  receipt will be on the sender
and will not be met by a transmission report generated by the sender's facsimile
machine);  or (iii) if sent by certified or  registered  mail or the  equivalent
(return receipt  requested),  on the date that mail is delivered or its delivery
is attempted;  unless that delivery (or attempted  delivery) or that receipt, as
applicable, is not on a Local Business Day or occurs after the close of business
on a Local  Business  Day, in which case that notice or  communication  shall be
deemed given and effective on the first  following day that is a Local  Business
Day.

         (b)  Notices  shall be  given to the  addresses  or  facsimile  numbers
reflected below:


                                       14





If to SBC, to:                      Swiss Bank Corporation, London Branch
                                    c/o SBC Warburg Inc.
                                    141 West Jackson Boulevard
                                    Chicago, Illinois 60604

                                    Attention:       Legal Department
                                    Facsimile:       (312) 554-5734
                                    Telephone:       (312) 554-5376

If to the Company, to:              Interneuron Pharmaceuticals, Inc.
                                    99 Heyden Ave.
                                    Lexington, MA 02173

                                    Attention:       Chief Financial Officer
                                    Facsimile:       617-674-2448
                                    Telephone:       617-861-8444

         (c)  Either  party may by notice to the other  change  the  address  or
facsimile number at which notices or other communications are to be given to it.

         7.2 Entire Agreement.  This Agreement,  together with the Confirmation,
constitute the entire agreement and understanding of the parties with respect to
their subject  matter and supersede all oral  communications  and prior writings
with respect thereto.

         7.3  Governing  Law and  Jurisdiction.  (a)  This  Agreement  shall  be
governed by and construed in accordance with New York law (without  reference to
choice of law doctrine).

         (b) With respect to any suit,  action or  proceedings  relating to this
Agreement   ("Proceedings"),   each  party   irrevocably   (i)  submits  to  the
non-exclusive jurisdiction of the courts of the State of New York and the United
States  District Court located in the Borough of Manhattan in New York City, and
(ii) waives any  objection  which it may have at any time to the laying of venue
of any  Proceedings  brought  in any such  court,  waives  any  claim  that such
Proceedings  have been brought in an  inconvenient  forum and further waives the
right to object, with respect to such Proceedings, that such court does not have
any  jurisdiction  over such party.  Nothing in this Agreement  precludes either
party from bringing Proceedings in any other jurisdiction, nor will the bringing
of  Proceedings  in any one or  more  jurisdictions  preclude  the  bringing  of
Proceedings in any other jurisdiction.

         (c) SBC hereby appoints Swiss Bank  Corporation,  New York Branch,  222
Broadway, New York, New York 10038, Attention: Legal Affairs, to receive, for it
and  on  its  behalf,  service  of  process  of  any  Proceedings.  The  parties
irrevocably consent to


                                       15





service of process  given in the manner  provided  for  notices in Section  7.1.
Nothing in this Agreement will affect the right of either party to serve process
in any other manner permitted by law.

         7.4 Amendments  and Waivers.  No amendment,  modification  or waiver in
respect of this Agreement  shall be effective  unless in writing and executed by
each of the  parties.  A failure  or delay in  exercising  any  right,  power or
privilege  in respect of this  Agreement  shall not be presumed to preclude  any
subsequent or further exercise of that right, power or privilege or the exercise
of any other right, power or privilege.

         7.5 Remedies Cumulative.  The rights,  powers,  remedies and privileges
provided in this  Agreement  are  cumulative  and not  exclusive  of any rights,
powers, remedies and privileges provided by law.

         7.6 Headings.  The headings used in this Agreement are for  convenience
of  reference  only and shall not affect the  construction  of, or be taken into
consideration in interpreting, this Agreement.

         7.7 No  Third-Party  Beneficiaries.  Except as  expressly  provided  in
Section  6.1(e),  nothing in this Agreement is intended or shall be construed to
confer upon any person other than the parties hereto any right,  remedy or claim
under or by reason of this Agreement.

         7.8  Survival.   The  representations,   warranties,   indemnities  and
agreements  contained in this  Agreement  shall remain in full force and effect,
regardless of any  investigation by or on behalf of any party, and shall survive
delivery of the Shares to SBC and resale of the Shares by SBC or any  affiliated
entity.

         7.9  Counterparts.  This  Agreement  may be  executed  in  one or  more
counterparts  with the same effect as if the signatures to each counterpart were
upon the same instrument.

         7.10  Assignability.  This  Agreement is not assignable by either party
without the prior  written  consent of the other;  provided that the Company may
assign this  Agreement to a successor in interest  pursuant to a transfer of all
or substantially all of its assets or pursuant to a consolidation or merger.



                                       16





         IN WITNESS WHEREOF,  Interneuron  Pharmaceuticals,  Inc. and Swiss Bank
Corporation,  London Branch, have executed this Agreement as of the day and year
first written above.


                                         INTERNEURON PHARMACEUTICALS, INC.


                                         By:    ___________________________
                                         Title: ___________________________


                                         SWISS BANK CORPORATION,
                                         LONDON BRANCH


                                         By:   ___________________________ 
                                         Title:___________________________ 
                                               

                                         By:   ___________________________ 
                                         Title:___________________________ 
                                               


                                       17




                                                                       EXHIBIT A

                           Form of Opinion of Counsel
                    In Connection With Registration Statement


         Counsel reasonably  satisfactory to SBC shall have furnished to SBC his
or  their  written  opinion,  dated  the  effective  date  of  the  Registration
Statement,  in form and substance reasonably  satisfactory to SBC, to the effect
that:

         (i) The Company has been duly incorporated and is validly existing as a
corporation  in good  standing  under  the laws of the State of  Delaware,  with
corporate  power and authority to own its properties and conduct its business as
described  in the  prospectus;  and each  subsidiary  of the  Company  that is a
"significant  subsidiary"  (as defined in Rule 12b-2 under the Exchange Act) has
been duly  incorporated  and is validly existing as a corporation and is in good
standing under the laws of its jurisdiction of  incorporation,  except where the
failure to be so would not have a material adverse effect on the Company and its
significant subsidiaries taken as a whole;

         (ii) The Company has been duly qualified as a foreign  corporation  for
the  transaction  of  business  and is in good  standing  under the laws of each
jurisdiction  other than the State of Delaware in which the ownership or leasing
of its properties, or the conduct of its business,  requires such qualification,
except to the extent the failure to be so  qualified in any  jurisdiction  would
not  have  a  material  adverse  effect  on  the  Company  and  its  significant
subsidiaries taken as a whole (such counsel being entitled to rely in respect of
the  opinion in this clause  upon  opinions  of local  counsel and in respect of
matters of fact upon certificates of officers of the Company, provided that such
counsel  shall state that they believe  that both SBC and they are  justified in
relying upon such opinions and certificates);

         (iii) The  Company's  authorized  capital  stock  conforms  as to legal
matters  in all  material  respects  to the  description  thereof  set  forth or
incorporated  by reference in the  Prospectus,  and all of the issued  shares of
capital stock of the Company  (including the Shares delivered in exercise of the
Call Warrant and registered for resale pursuant to the  Registration  Statement)
have  been  duly and  validly  authorized  and  issued  and are  fully  paid and
non-assessable;  all of the issued  shares of capital  stock of the  significant
subsidiaries  held  directly or  indirectly  by the  Company  have been duly and
validly  authorized  and  issued,  are fully  paid and  non-assessable;  and the
Company's  stockholders  have no  preemptive  rights with  respect to the Shares
delivered in exercise of the Call Warrant (such  counsel being  entitled to rely
in respect of the opinion in this clause upon  opinions of local  counsel and in
respect of matters of fact upon  certificates  of officers of the Company or its
subsidiaries, provided that such counsel shall state that they believe that both
SBC and they are justified in relying upon such opinions and certificates);






         (iv) To the best of such  counsel's  knowledge  and  other  than as set
forth or  incorporated  by  reference in the  Prospectus,  there are no legal or
governmental  proceedings pending to which the Company or any of its significant
subsidiaries  is a party or of which any  property  of the Company or any of its
significant  subsidiaries is the subject which,  if determined  adversely to the
Company or any of its  significant  subsidiaries,  would  individually or in the
aggregate  have  a  material   adverse   effect  on  the  business   operations,
consolidated  financial position,  shareholders' equity or results of operations
of the Company and its significant subsidiaries,  taken as a whole; and, to such
counsel's  knowledge,   no  such  proceedings  are  threatened  by  governmental
authorities  or  threatened by others,  provided that such counsel  expresses no
opinion on any such  matter  relating to the U.S.  Food and Drug  Administration
("FDA");

         (v) The documents  incorporated  by reference in the Prospectus  (other
than the financial statements, related schedules and other financial information
therein, as to which such counsel need express no opinion), when they were filed
with  the  Commission  complied  as to form in all  material  respects  with the
requirements of the Exchange Act and the rules and regulations of the Commission
thereunder; and

         (vi) The  Registration  Statement  and the  Prospectus  (other than the
financial statements, related schedules and other financial information therein,
as to which  such  counsel  need  express no  opinion)  comply as to form in all
material  respects with the requirements of the Securities Act and the rules and
regulations  thereunder;  and such  counsel do not know of any  amendment to the
Registration  Statement required to be filed or any contracts or other documents
of a character required to be filed as an exhibit to the Registration  Statement
or required to be  incorporated  by reference into the Prospectus or required to
be described in the Registration Statement or the Prospectus which are not filed
or incorporated by reference or described as required.

         In  addition to the matters  set forth  above,  the opinion  shall also
contain a statement to the effect that while such counsel are not passing  upon,
and do not assume responsibility for, the accuracy,  completeness or fairness of
the   Registration   statement  or  the  Prospectus,   including  the  documents
incorporated by reference therein, based upon the procedures referred to in such
opinion  nothing has come to the  attention of such  counsel  which leads him or
them to believe (i) that the Registration  Statement as of its effective date or
the  Prospectus  as of its date (other than the  financial  statements,  related
schedules and other financial  information therein as to which such counsel need
express no belief)  contains an untrue  statement of a material fact or omits to
state a material  fact  required to be stated  therein or  necessary to make the
statements  therein,  in light of the circumstances  under which they were made,
not  misleading or (ii) that any of the documents  incorporated  by reference in
the Prospectus which were filed with the Commission prior to such effective time
(other than the financial  statements,  related  schedules  and other  financial
information therein, as to which such counsel need express no belief), as of the
respective dates when they were filed with the Commission in each


                                        2




case  after  excluding  any  statement  in any  such  document  which  does  not
constitute part of the Registration Statement or the Prospectus pursuant to Rule
412 of Regulation C under the Securities Act and after substituting therefor any
statement modifying or superseding such excluded statement,  contained an untrue
statement of a material  fact or omitted to state a material  fact  necessary in
order to make the statements  therein,  in the light of the circumstances  under
which they were made when such documents were so filed, not misleading, provided
in each case that such counsel expresses no opinion as to FDA or patent matters.



                                        3




<TABLE> <S> <C>

<ARTICLE>                     5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL  INFORMATION EXTRACTED FROM THE BALANCE
SHEET AND STATEMENT OF OPERATIONS  AND IS QUALIFIED IN ITS ENTIRETY BY REFERENCE
TO SUCH FINANCIAL STATEMENTS
</LEGEND>
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                              Sep-30-1997
<PERIOD-END>                                   Mar-31-1997
<CASH>                                         93,414,000
<SECURITIES>                                   29,471,000
<RECEIVABLES>                                  1,926,000
<ALLOWANCES>                                   0
<INVENTORY>                                    6,356,000
<CURRENT-ASSETS>                               137,128,000
<PP&E>                                         5,391,000
<DEPRECIATION>                                 (2,367,000)
<TOTAL-ASSETS>                                 177,792,000
<CURRENT-LIABILITIES>                          25,142,000
<BONDS>                                        0
                          0
                                    3,500,000
<COMMON>                                       41,000
<OTHER-SE>                                     128,880,000<F1>
<TOTAL-LIABILITY-AND-EQUITY>                   177,792,000
<SALES>                                        14,173,000
<TOTAL-REVENUES>                               37,466,000
<CGS>                                          12,302,000
<TOTAL-COSTS>                                  52,992,000
<OTHER-EXPENSES>                               0
<LOSS-PROVISION>                               0
<INTEREST-EXPENSE>                             152,000
<INCOME-PRETAX>                                (10,781,000)
<INCOME-TAX>                                   0
<INCOME-CONTINUING>                            (10,781,000)
<DISCONTINUED>                                 0
<EXTRAORDINARY>                                0
<CHANGES>                                      0
<NET-INCOME>                                   (10,781,000)
<EPS-PRIMARY>                                  (0.26)
<EPS-DILUTED>                                  0
<FN>
<F1>   Additional paid - in capital - $249,020,000
       Accumulated Deficit - $ (117,559,000)
       FAS 115 Securities Adjustment - $(218,000)
       Treasury Stock - $(2,363,000)
</FN>
        



</TABLE>


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