INTERNEURON PHARMACEUTICALS INC
S-8, 1997-04-11
PHARMACEUTICAL PREPARATIONS
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     As filed with the Securities and Exchange Commission on April 11, 1997
                        Registration No. 333- __________
         --------------------------------------------------------------


                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                        Interneuron Pharmaceuticals, Inc.
 -------------------------------------------------------------------------------

             (Exact name of registrant as specified in its charter)

                                    Delaware
 -------------------------------------------------------------------------------

         (State or other jurisdiction of incorporation or organization)

                                    043047911
 -------------------------------------------------------------------------------

                      (I.R.S. employer identification no.)

           One Ledgemont Center, 99 Hayden Avenue, Lexington, MA 02173
 -------------------------------------------------------------------------------

                    (Address of principal executive offices)

                    1994 Long-Term Incentive Plan, as amended
                              (Full title of plan)

                        Glenn L. Cooper, M.D., President
                        Interneuron Pharmaceuticals, Inc.
                              One Ledgemont Center
                                99 Hayden Avenue
                         Lexington, Massachusetts 02173
                     (Name and address of agent for service)

                                 (617) 861-8444
          (Telephone number, including area code, of agent for service)

                                    Copy to:
                               Jill M. Cohen, Esq.
                      Bachner, Tally, Polevoy & Misher LLP
                               380 Madison Avenue
                               New York, NY 10017







                         CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
- -------------------------------------------------------------------------------------------------------------------

                                        Proposed          Proposed
                                        Maximum           Maximum
                                        Offering          Aggregate                               Amount of
Title of Securities                       to be           Price Per        Offering             Registration
 to be Registered                       Registered          Share(1)         Price                   Fee
 ----------------                       ----------          --------         -----                   ---
<S>                                     <C>               <C>              <C>                  <C>
Common Stock, $.001
  par value                             3,000,000         $18.69           $56,070,000          $16,989.21
- -------------------------------------------------------------------------------------------------------------------
</TABLE>

(1)      Estimated  in  accordance  with Rule  457(h)  solely for the purpose of
         calculating the registration fee. The price shown is the average of the
         high and low prices of the Common Stock on April 8, 1997 as reported on
         the Nasdaq National Market.








                                     PART II


               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.        Incorporation of Documents by Reference

               The Registration Statement on Form S-8 (File No. 33-75826), filed
by Interneuron  Pharmaceuticals,  Inc. (the  "Registrant") on July 19, 1995, and
the  documents  listed  below are hereby  incorporated  by  reference  into this
Registration  Statement,  and all documents subsequently filed by the Registrant
pursuant to Sections 13(a),  13(c), 14 and 15(d) of the Securities  Exchange Act
of 1934, as amended,  prior to the filing of a  post-effective  amendment  which
indicates that all securities  offered have been sold or which  deregisters  all
securities  then  remaining  unsold,  shall  be  deemed  to be  incorporated  by
reference in this Registration  Statement and to be part hereof from the date of
filing such documents:

               (a)    The  Registrant's  Annual  Report on Form  10-K  (File No.
                      0-18728) for its fiscal year ending September 30, 1996;

               (b)    The Registrant's definitive Proxy Statement, dated January
                      28,  1997,  as filed  with  the  Securities  and  Exchange
                      Commission  (the  "Commission")  in  connection  with  the
                      Company's Annual Meeting of Stockholders  held on March 5,
                      1997;

               (c)    The  Registrant's  quarterly  report  on Form 10-Q for the
                      quarterly period ended December 31, 1996;

               (d)    The  Registrant's  report  on Form 8-K as  filed  with the
                      Commission on February 18, 1997;

               (e)    The  Registrant's  report  on Form 8-K as  filed  with the
                      Commission on March 14, 1997; and

               (f)    The  Registrant's   Registration  Statement  on  Form  8-A
                      declared   effective   on  March  8,  1990,   as  amended,
                      registering the Common Stock,  $.001 par value,  under the
                      Securities Exchange Act of 1934, as amended.

Item 8.        Exhibits

               5.1    Opinion of  Bachner,  Tally,  Polevoy & Misher  LLP,  with
                      respect  to  the  legality  of  the  Common  Stock  to  be
                      registered hereunder

               10.65  1994 Long-Term Incentive Plan, as amended

               23.1   Consent of Coopers & Lybrand L.L.P.

               23.2   Consent of Bachner, Tally, Polevoy & Misher LLP (contained
                      in Exhibit 5.1)







                                   SIGNATURES

               Pursuant to the  requirements  of the Securities Act of 1933, the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this registration
statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of Lexington, State of Massachusetts, on the 11th day of
April, 1997.

                                           INTERNEURON PHARMACEUTICALS, INC.


                                           By: /s/ Glenn L. Cooper
                                               -------------------------------
                                              Glenn L. Cooper, M.D., President
                                              and Chief Executive Officer
                                              (Principal Executive Officer)


               Pursuant to the  requirements of the Securities Act of 1933, this
registration  statement  has been signed below by the  following  persons in the
capacities and as of the date indicated.

<TABLE>
<CAPTION>
                 <S>                              <C>                                   <C> 
              Signature                          Title                                  Date
              ---------                          -----                                  ----

   /s/ Glenn L. Cooper                      President and Chief Executive               April  11, 1997
- -----------------------------------          Officer and Director
Glenn L. Cooper , M.D.                       (Principal Executive Officer)

                                            Chairman of the Board of                    April    , 1997
- -----------------------------------          Directors
Lindsay A. Rosenwald, M.D.         

 /s/ Harry J. Gray                          Director                                    April  11, 1997
- -----------------------------------
Harry J. Gray

 /s/ Alexander M. Haig                      Director                                    April  11, 1997
- -----------------------------------
Alexander M. Haig, Jr.

 /s/ Peter Barton Hutt                      Director                                    April  11, 1997
- -----------------------------------
Peter Barton Hutt

 /s/ Malcolm Morville                       Director                                    April  11, 1997
- -----------------------------------
Malcolm Morville, Ph.D.

 /s/ Robert K. Mueller                      Director                                    April  11, 1997
- -----------------------------------
Robert K. Mueller







 /s/ Lee J. Schroeder                       Director                                    April  11, 1997
- -----------------------------------
Lee J. Schroeder

 /s/ David B. Sharrock                      Director                                    April  11, 1997
- -----------------------------------
David B. Sharrock

 /s/ Richard Wurtman                        Director                                    April  11, 1997
- -----------------------------------
Richard Wurtman, M.D.

/s/ Dale Ritter                              Vice President, Corporate Controller       April  11, 1997
- -----------------------------------          and Chief Accounting Officer
Dale Ritter                                  (Principal Accounting Officer)

</TABLE>








                                INDEX TO EXHIBITS
                        INTERNEURON PHARMACEUTICALS, INC.


Exhibit
  No.             Description
  ---             -----------

5.1               Opinion of Bachner, Tally, Polevoy & Misher LLP,
                  with respect to the legality of the Common
                  Stock to be registered hereunder

10.65             1994 Long-Term Incentive Plan, as amended

23.1              Consent of Coopers & Lybrand L.L.P.

23.2              Consent of Bachner, Tally, Polevoy & Misher LLP
                  (contained in Exhibit 5)






                                                                     Exhibit 5.1




           2172

                                                  April 10, 1997

Interneuron Pharmaceuticals, Inc.
One Ledgemont Center
99 Hayden Avenue, Suite 340
Lexington, Massachusetts  02173

                  RE:     REGISTRATION STATEMENT ON FORM S-8
                          ----------------------------------

Ladies and Gentlemen:

                  We  have  served  as  your  counsel  in  connection  with  the
preparation  of your  Registration  Statement  on Form  S-8  (the  "Registration
Statement") to be filed with the Securities  and Exchange  Commission  under the
Securities  Act of 1933, as amended,  representing  the offering and issuance to
certain persons under the 1994 Long-Term Incentive Plan, as amended (the "Plan")
of 3,000,000 shares of your common stock, $.001 par value (the "Common Stock").

                  We have examined such corporate records, documents and matters
of law as we have considered appropriate for the purposes of this opinion.

                  Based upon such examination, it is our opinion that the Common
Stock,  when issued in the manner described in the manner described in the Plan,
will be validly issued, fully paid and non-assessable.

                  We  consent  to  the  reference   made  to  our  firm  in  the
Registration  Statement  and to the filing of this  opinion as an exhibit to the
Registration Statement.


                  Very truly yours,

                  /s/ Bachner, Tally, Polevoy & Misher LLP

                  BACHNER, TALLY, POLEVOY
                     & MISHER LLP


                                                                               
                                       -1-


                                                                   Exhibit 10.65


                    1994 LONG-TERM INCENTIVE PLAN, AS AMENDED


1.            Purpose.

              The purpose of this plan (the "Plan") is to secure for INTERNEURON
PHARMACEUTICALS,  INC. (the "Company") and its stockholders the benefits arising
from capital  stock  ownership by  employees,  officers  and  directors  of, and
consultants  or advisors to, the Company who are expected to  contribute  to the
Company's  future  growth  and  success.  Except  where  the  context  otherwise
requires,  the term "Company" shall include all present and future  subsidiaries
of the Company as defined in Sections 424(e) and 424(f) of the Internal  Revenue
Code of 1986,  as  amended or  replaced  from time to time (the  "Code").  Those
provisions  of the Plan which make express  reference to Section 422 shall apply
only to Incentive Stock Options (as that term is defined in the Plan).

2.            Type of Options and Administration.

              (a) Types of Options.  Options granted  pursuant to the Plan shall
be authorized by action of the Board of Directors of the Company (or a committee
designated by the Board of Directors) and may be either  incentive stock options
("Incentive  Stock Options") meeting the requirements of Section 422 of the Code
or  non-statutory  options  which are not intended to meet the  requirements  of
Section 422 of the Code.

              (b)  Administration.  The Plan will be administered by a committee
(the  "Committee")  appointed by the Board of  Directors  of the Company,  whose
construction and interpretation of the terms and provisions of the Plan shall be
final  and  conclusive.  The  delegation  of powers  to the  Committee  shall be
consistent with applicable laws or regulations  (including,  without limitation,
applicable  state  law and Rule  16b-3  ("Rule  16b-3")  promulgated  under  the
Securities  Exchange Act of 1934 (the "Exchange  Act"), or any successor  rule).
The Committee may in its sole discretion grant options to purchase shares of the
Company's  Common Stock,  $.001 par value per share  ("Common  Stock") and issue
shares upon  exercise of such  options as  provided in the Plan.  The  Committee
shall have authority, subject to the express provisions of the Plan, to construe
the respective option  agreements and the Plan, to prescribe,  amend and rescind
rules  and  regulations  relating  to the  Plan,  to  determine  the  terms  and
provisions of the respective option agreements, which need not be identical, and
to make all other  determinations in the judgment of the Committee  necessary or
desirable  for the  administration  of the Plan.  The  Committee may correct any
defect or supply any omission or reconcile any  inconsistency  in the Plan or in
any option  agreement in the manner and to the extent it shall deem expedient to
carry the Plan into effect and it shall be the sole and final judge

                                                                              
                                       -2-





of such expediency. No director or person acting pursuant to authority delegated
by the Committee shall be liable for any action or determination  under the Plan
made in good faith.  Subject to adjustment as provided in Section 15 below,  the
aggregate  number of  shares of Common  Stock  that may be  subject  to  Options
granted  to any person in a  calendar  year shall not exceed 25% of the  maximum
number of shares  which may be issued and sold  under the Plan,  as set forth in
Section 4 hereof, as such section may be amended from time to time.

              (c)  Applicability  of Rule 16b-3.  Those  provisions  of the Plan
which make  express  reference  to Rule 16b-3 shall apply to the Company only at
such time as the Company's  Common Stock is  registered  under the Exchange Act,
subject to the last sentence of Section  3(b),  and then only to such persons as
are  required  to file  reports  under  Section  16(a)  of the  Exchange  Act (a
"Reporting Person").

3.            Eligibility.

              (a)  General.  Options  may be granted to persons  who are, at the
time of grant,  employees,  officers or directors of, or consultants or advisors
to, the Company or any subsidiaries of the Company as defined in Sections 424(e)
and 424(f) of the Code ("Participants")  provided,  that Incentive Stock Options
may only be granted to individuals  who are employees of the Company (within the
meaning of Section 3401(c) of the Code). A person who has been granted an option
may, if he or she is otherwise  eligible,  be granted  additional options if the
Committee shall so determine.

              (b) Grant of Options to  Reporting  Persons.  The  selection  of a
director or an officer who is a Reporting  Person (as the terms  "director"  and
"officer"  are defined for  purposes of Rule 16b-3) as a recipient of an option,
the timing of the option grant,  the exercise price of the option and the number
of shares  subject to the option shall be determined  either (i) by the Board of
Directors,  (ii) by a committee  consisting of two or more directors having full
authority to act in the matter or (iii)  pursuant to  provisions  for  automatic
grants set forth in Section 3(c) below.

              (c)  Directors'  Options.  Directors  of the  Company  who are not
employees and who are not  stockholders  of the Company  beneficially  owning in
excess  of  5% of  the  outstanding  Common  Stock  of  the  Company  ("Eligible
Directors") will receive an option ("Director Option") to purchase 20,000 shares
of Common  Stock on the date that such  person is first  elected or  appointed a
director  ("Initial  Director  Option").   Commencing  on  the  day  immediately
following  the date of the annual  meeting  of  stockholders  for the  Company's
fiscal year ending  September 30, 1996,  each Eligible  Director will receive an
automatic  grant  ("Automatic  Grant") of a Director  Option to  purchase  5,000
shares of Common Stock,  other than  Eligible  Directors who received an Initial
Director  Option since the most recent  Automatic  Grant, on the day immediately
following  the date of each  annual  meeting  of  stockholders,  as long as such
director  is a member of the Board of  Directors.  The  exercise  price for each
share  subject to a Director  Option  shall be equal to the fair market value of
the Common Stock on the date of grant. Director Options shall become exercisable
in four equal annual installments

                                                                               
                                       -3-





commencing  one year from the date the  option is  granted  and will  expire the
earlier of 10 years after the date of grant or 90 days after the  termination of
the director's service on the Board.

4.            Stock Subject to Plan.

              The stock  subject  to  options  granted  under the Plan  shall be
shares of  authorized  but  unissued  or  reacquired  Common  Stock.  Subject to
adjustment  as  provided in Section 15 below,  the  maximum  number of shares of
Common  Stock of the  Company  which  may be issued  and sold  under the Plan is
6,000,000 shares. If an option granted under the Plan shall expire, terminate or
is  cancelled  for any  reason  without  having  been  exercised  in  full,  the
unpurchased  shares  subject  to  such  option  shall  again  be  available  for
subsequent option grants under the Plan.

5.            Forms of Option Agreements.

              As a  condition  to the  grant of an option  under the Plan,  each
recipient  of an  option  shall  execute  an option  agreement  in such form not
inconsistent  with the Plan as may be approved by the Board of  Directors.  Such
option agreements may differ among recipients.

6.            Purchase Price.

              (a)  General.  The purchase  price per share of stock  deliverable
upon the exercise of an option shall be  determined by the Board of Directors at
the time of  grant of such  option;  provided,  however,  that in the case of an
Incentive  Stock Option,  the exercise  price shall not be less than 100% of the
Fair Market Value (as  hereinafter  defined) of such stock, at the time of grant
of such  option,  or less  than 110% of such  Fair  Market  Value in the case of
options  described in Section  11(b).  "Fair Market  Value" of a share of Common
Stock of the Company as of a specified  date for the  purposes of the Plan shall
mean  the  closing  price  of a  share  of the  Common  Stock  on the  principal
securities  exchange (including the Nasdaq National Market) on which such shares
are traded on the day  immediately  preceding  the date as of which Fair  Market
Value is being  determined,  or on the next  preceding date on which such shares
are traded if no shares were traded on such immediately preceding day, or if the
shares are not traded on a  securities  exchange,  Fair  Market  Value  shall be
deemed to be the  average of the high bid and low asked  prices of the shares in
the  over-the-counter  market on the day  immediately  preceding  the date as of
which Fair Market Value is being  determined  or on the next  preceding  date on
which such high bid and low asked  prices were  recorded.  If the shares are not
publicly traded, Fair Market Value of a share of Common Stock (including, in the
case of any repurchase of shares,  any distributions  with respect thereto which
would be  repurchased  with the shares) shall be determined in good faith by the
Board of Directors. In no case shall Fair Market Value be determined with regard
to restrictions other than restrictions which, by their terms, will never lapse.

              (b)  Payment of Purchase Price. Options granted under the Plan may
provide for the payment of the exercise  price by delivery of cash or a check to
the order of the Company

                                                                               
                                       -4-





in an amount equal to the exercise price of such options,  or by any other means
which the Board of Directors  determines are consistent  with the purpose of the
Plan and with applicable laws and regulations  (including,  without  limitation,
the provisions of Rule 16b-3 and Regulation T promulgated by the Federal Reserve
Board).

7.            Option Period.

              Subject to  earlier  termination  as  provided  in the Plan,  each
option and all rights  thereunder shall expire on such date as determined by the
Board of Directors and set forth in the applicable option  agreement,  provided,
that such date  shall not be later  than (10) ten years  after the date on which
the option is granted.

8.            Exercise of Options.

                  Each option granted under the Plan shall be exercisable either
in full or in installments at such time or times and during such period as shall
be set forth in the option  agreement  evidencing  such  option,  subject to the
provisions of the Plan. Subject to the requirements in the immediately preceding
sentence, if an option is not at the time of grant immediately exercisable,  the
Board of Directors may (i) in the agreement evidencing such option,  provide for
the  acceleration  of the exercise date or dates of the subject  option upon the
occurrence  of specified  events,  and/or (ii) at any time prior to the complete
termination of an option, accelerate the exercise date or dates of such option.

9.            Transferability of Options.

              No  incentive  stock  option  granted  under  this  Plan  shall be
assignable or otherwise  transferable  by the optionee  except by will or by the
laws of descent and distribution or pursuant to a qualified  domestic  relations
order  as  defined  in the  Code or Title I of the  Employee  Retirement  Income
Security Act, or the rules  thereunder.  The Committee  may, in its  discretion,
authorize  all or a portion  of any  non-statutory  options  to be granted to an
optionee  to be on terms  which  permit  transfer  by such  optionee  to (i) the
spouse,  children or grandchildren of the optionee ("Immediate Family Members"),
(ii) a trust or  trusts  for the  exclusive  benefit  of such  Immediate  Family
Members,  or (iii) a partnership in which such Immediate  Family Members are the
only partners,  provided that (w) the options must be held by the optionee for a
period  of  at  least  one  month  prior  to  transfer,  (x)  there  may  be  no
consideration for any such transfer,  (y) the stock option agreement pursuant to
which such  options are granted  must be  approved  by the  Committee,  and must
expressly provide for  transferability in a manner consistent with this Section,
and (z) subsequent  transfers of transferred  options shall be prohibited except
by will or the laws of descent  and  distribution  or  pursuant  to a  qualified
domestic  relations  order as  defined  in the  Code or Title I of the  Employee
Retirement Income Security Act, or the rules thereunder. Following transfer, any
such options  shall  continue to be subject to the same terms and  conditions as
were applicable immediately prior to transfer, provided that for purposes of the
Plan the term "optionee" shall be deemed to refer to the transferee.  The events
of  termination  of employment of Section 10 hereof shall continue to be applied
with respect to the original

                                                                              
                                       -5-





optionee. An option may be exercised during the lifetime of the optionee only by
the original  optionee.  In the event an optionee dies during his  employment by
the  Company  or any of its  subsidiaries,  or  during  the  three-month  period
following  the  date  of  termination  of  such  employment,  his  option  shall
thereafter be exercisable,  during the period specified in the option agreement,
by his executors or  administrators  to the full extent to which such option was
exercisable  by the  optionee  at the time of his death  during the  periods set
forth in Section 10 or 11(d).

10.           Effect of Termination of Employment or Other Relationship.

              Except as  provided  in Section  11(d) with  respect to  Incentive
Stock Options and except as otherwise determined by the Committee at the date of
grant of an Option,  and subject to the  provisions of the Plan, an optionee may
exercise an option at any time within six (6) months  following the  termination
of the optionee's  employment or other  relationship  with the Company or within
one (1)  year if such  termination  was due to the  death or  disability  of the
optionee but, except in the case of the optionee's death, in no event later than
the  expiration  date  of the  Option.  If  the  termination  of the  optionee's
employment is for cause or is otherwise attributable to a breach by the optionee
of an employment or  confidentiality  or  non-disclosure  agreement,  the option
shall expire  immediately  upon such  termination.  The Board of Directors shall
have the power to determine what constitutes a termination for cause or a breach
of an employment or  confidentiality  or  non-disclosure  agreement,  whether an
optionee has been  terminated  for cause or has breached such an agreement,  and
the date upon  which  such  termination  for cause or  breach  occurs.  Any such
determinations shall be final and conclusive and binding upon the optionee.

11.           Incentive Stock Options.

              Options  granted under the Plan which are intended to be Incentive
Stock Options shall be subject to the following additional terms and conditions:

              (a) Express Designation. All Incentive Stock Options granted under
the Plan shall, at the time of grant, be specifically  designated as such in the
option agreement covering such Incentive Stock Options.

              (b) 10%  Stockholder.  If any employee to whom an Incentive  Stock
Option  is to be  granted  under  the Plan is,  at the time of the grant of such
option, the owner of stock possessing more than 10% of the total combined voting
power of all classes of stock of the  Company  (after  taking  into  account the
attribution of stock  ownership  rules of Section 424(d) of the Code),  then the
following  special  provisions shall be applicable to the Incentive Stock Option
granted to such individual:

                   (i) The purchase  price per share of the Common Stock subject
              to such Incentive  Stock Option shall not be less than 110% of the
              Fair  Market  Value of one  share of  Common  Stock at the time of
              grant; and

                                                                               
                                       -6-





                   (ii) The option  exercise  period shall not exceed five years
              from the date of grant.

              (c) Dollar  Limitation.  For so long as the Code shall so provide,
options  granted to any employee under the Plan (and any other  incentive  stock
option plans of the Company)  which are intended to constitute  Incentive  Stock
Options  shall not  constitute  Incentive  Stock Options to the extent that such
options,  in the  aggregate,  become  exercisable  for the first time in any one
calendar year for shares of Common Stock with an aggregate Fair Market Value, as
of the respective date or dates of grant, of more than $100,000.

              (d) Termination of Employment,  Death or Disability.  No Incentive
Stock Option may be exercised unless, at the time of such exercise, the optionee
is,  and has been  continuously  since  the date of grant of his or her  option,
employed by the Company, except that:

                   (i) an Incentive  Stock  Option may be  exercised  within the
              period of three months after the date the optionee ceases to be an
              employee of the  Company  (or within such lesser  period as may be
              specified in the applicable option agreement),  provided, that the
              agreement  with  respect  to such  option may  designate  a longer
              exercise  period  and that the  exercise  after  such  three-month
              period shall be treated as the exercise of a non-statutory  option
              under the Plan;

                   (ii) if the optionee dies while in the employ of the Company,
              or within three  months  after the  optionee  ceases to be such an
              employee,  the  Incentive  Stock  Option may be  exercised  by the
              person to whom it is  transferred  by will or the laws of  descent
              and  distribution  within the period of one year after the date of
              death (or within such  lesser  period as may be  specified  in the
              applicable option agreement); and

                   (iii) if the optionee becomes disabled (within the meaning of
              Section 22(e)(3) of the Code or any successor  provisions thereto)
              while in the employ of the Company, the Incentive Stock Option may
              be  exercised  within  the  period of one year  after the date the
              optionee ceases to be such an employee  because of such disability
              (or  within  such  lesser  period  as  may  be  specified  in  the
              applicable option agreement).

For all  purposes  of the Plan and any option  granted  hereunder,  "employment"
shall be defined in accordance with the provisions of Section  1.421-7(h) of the
Income Tax  Regulations  (or any  successor  regulations).  Notwithstanding  the
foregoing  provisions,  no Incentive  Stock  Option may be  exercised  after its
expiration date.

12.           Additional Provisions.

              (a) Additional Option  Provisions.  The Board of Directors may, in
its sole discretion, include additional provisions in option agreements covering
options granted under the

                                                                               
                                       -7-





Plan, including without limitation restrictions on transfer,  repurchase rights,
rights of first refusal,  commitments to pay cash bonuses,  to make, arrange for
or guaranty  loans or to transfer  other  property to optionees upon exercise of
options,  or such  other  provisions  as shall  be  determined  by the  Board of
Directors;  provided,  that such additional provisions shall not be inconsistent
with any other  term or  condition  of the Plan and such  additional  provisions
shall not cause any  Incentive  Stock Option  granted  under the Plan to fail to
qualify as an Incentive  Stock  Option  within the meaning of Section 422 of the
Code.

              (b) Acceleration,  Extension,  Etc. The Board of Directors may, in
its sole  discretion,  (i)  accelerate  the  date or  dates on which  all or any
particular  option or options  granted  under the Plan may be  exercised or (ii)
extend the dates during which all, or any particular,  option or options granted
under the Plan may be exercised; provided, however, that no such extension shall
be  permitted  if it would cause the Plan to fail to comply with  Section 422 of
the Code or with Rule 16b-3 (if applicable).

13.           General Restrictions.

              (a)  Investment  Representations.  The  Company  may  require  any
optionee,  as a condition of exercising such option, to give written  assurances
in substance and form satisfactory to the Company to the effect that such person
is acquiring the Common Stock subject to the option or award, for his or her own
account  for  investment  and not with  any  present  intention  of  selling  or
otherwise  distributing the same, and to such other effects as the Company deems
necessary or appropriate  in order to comply with federal and  applicable  state
securities  laws, or with  covenants or  representations  made by the Company in
connection with any public offering of its Common Stock, including any "lock-up"
or other restriction on transferability.

              (b) Compliance  With  Securities Law. Each Option shall be subject
to the requirement that if, at any time,  counsel to the Company shall determine
that the listing,  registration or  qualification  of the shares subject to such
option or award upon any securities  exchange or automated  quotation  system or
under any state or federal  law, or the consent or approval of any  governmental
or regulatory  body, or that the  disclosure  of non-public  information  or the
satisfaction  of any other  condition  is  necessary  as a  condition  of, or in
connection  with the  issuance  of shares  thereunder,  such  option  may not be
exercised,   in  whole  or  in  part,   unless   such   listing,   registration,
qualification, consent or approval, or satisfaction of such condition shall have
been  effected or obtained on  conditions  acceptable to the Board of Directors.
Nothing  herein shall be deemed to require the Company to apply for or to obtain
such listing, registration or qualification, or to satisfy such condition.

14.           Rights as a Stockholder.

              The holder of an option shall have no rights as a stockholder with
respect to any shares covered by the option (including,  without limitation, any
rights to receive  dividends  or  non-cash  distributions  with  respect to such
shares) until the date of issue of a stock certificate to

                                                                               
                                       -8-





him or her for such shares.  No adjustment  shall be made for dividends or other
rights for which the record date is prior to the date such stock  certificate is
issued.

15.           Adjustment Provisions for  Recapitalizations,  Reorganizations and
Related Transactions.

              (a) Recapitalizations and Related Transactions.  If, through or as
a result of any recapitalization, reclassification, stock dividend, stock split,
reverse stock split or other similar transaction,  (i) the outstanding shares of
Common Stock are  increased,  decreased or exchanged  for a different  number or
kind of shares or other securities of the Company,  or (ii) additional shares or
new or different shares or other non-cash assets are distributed with respect to
such  shares  of  Common  Stock  or  other   securities,   an  appropriate   and
proportionate  adjustment  shall be made in (x) the  maximum  number and kind of
shares reserved for issuance under or otherwise referred to in the Plan, (y) the
number and kind of shares or other  securities  subject to any then  outstanding
options  under the Plan,  and (z) the price for each  share  subject to any then
outstanding  options under the Plan,  without  changing the  aggregate  purchase
price  as  to  which  such  options  remain  exercisable.   Notwithstanding  the
foregoing,  no  adjustment  shall be made  pursuant  to this  Section 15 if such
adjustment  (i) would cause the Plan to fail to comply  with  Section 422 of the
Code or with Rule 16b-3 or (ii) would be  considered  as the  adoption  of a new
plan requiring stockholder approval.

              (b)   Reorganization,   Merger  and  Related   Transactions.   All
outstanding  Options under the Plan shall become fully  exercisable for a period
of sixty (60) days following the occurrence of any Trigger Event, whether or not
such  Options  are then  exercisable  under  the  provisions  of the  applicable
agreements relating thereto.  For purposes of the Plan, a "Trigger Event" is any
one of the following events:

                   (i) the  date on which  shares  of  Common  Stock  are  first
         purchased pursuant to a tender offer or exchange offer (other than such
         an offer by the Company,  any Subsidiary,  any employee benefit plan of
         the Company or of any  Subsidiary or any entity holding shares or other
         securities  of the  Company for or pursuant to the terms of such plan),
         whether or not such offer is  approved  or opposed by the  Company  and
         regardless of the number of shares purchased pursuant to such offer;

                   (ii) the date the Company acquires  knowledge that any person
         or group  deemed a person  under  Section  13(d)-3 of the  Exchange Act
         (other than the Company,  any Subsidiary,  any employee benefit plan of
         the Company or of any Subsidiary or any entity holding shares of Common
         Stock or other  securities  of the Company for or pursuant to the terms
         of any such plan or any  individual  or  entity  or group or  affiliate
         thereof which acquired its beneficial  ownership  interest prior to the
         date the Plan was adopted by the Board),  in a transaction or series of
         transactions,  has become the beneficial owner,  directly or indirectly
         (with beneficial ownership determined as provided in Rule 13d-3, or any
         successor  rule,  under the Exchange Act), of securities of the Company
         entitling the person or group to 30% or more of all votes

                                                                             
                                       -9-





         (without  consideration  of the  rights  of any class or stock to elect
         directors by a separate  class vote) to which all  shareholders  of the
         Company  would be  entitled in the  election of the Board of  Directors
         were an election held on such date;

                   (iii) the date,  during any period of two consecutive  years,
         when  individuals  who at the beginning of such period  constitute  the
         Board of Directors of the Company cease for any reason to constitute at
         least a majority  thereof,  unless the election,  or the nomination for
         election by the  stockholders of the Company,  of each new director was
         approved by a vote of at least  two-thirds of the directors  then still
         in office who were directors at the beginning of such period; and

                   (iv) the date of approval by the  stockholders of the Company
         of an agreement (a "reorganization agreement") providing for:

                                    (A)  The  merger  or  consolidation  of  the
                  Company with another corporation where the stockholders of the
                  Company, immediately prior to the merger or consolidation,  do
                  not  beneficially   own,   immediately  after  the  merger  or
                  consolidation,  shares  of the  corporation  issuing  cash  or
                  securities  in the  merger  or  consolidation  entitling  such
                  stockholders   to  65%  or   more   of  all   votes   (without
                  consideration  of the  rights  of any  class of stock to elect
                  directors by a separate class vote) to which all  shareholders
                  of such  corporation  would be  entitled  in the  election  of
                  directors  or where the members of the Board of  Directors  of
                  the Company, immediately prior to the merger or consolidation,
                  do  not,   immediately  after  the  merger  or  consolidation,
                  constitute  a  majority  of  the  Board  of  Directors  of the
                  corporation  issuing  cash  or  securities  in the  merger  or
                  consolidation; or

                                    (B) The sale or other  disposition of all or
                  substantially all the assets of the Company.

                  (c) Board Authority to Make Adjustments. Any adjustments under
this Section 15 will be made by the Board of Directors,  whose  determination as
to what adjustments,  if any, will be made and the extent thereof will be final,
binding and  conclusive.  No fractional  shares will be issued under the Plan on
account of any such adjustments.

16.               Merger, Consolidation, Asset Sale, Liquidation, etc.

                  (a) General. In the event of a consolidation or merger or sale
of all or  substantially  all of the assets of the Company in which  outstanding
shares of Common Stock are exchanged for  securities,  cash or other property of
any other corporation or business entity or in the event of a liquidation of the
Company, the Board of Directors of the Company, or the board of directors of any
corporation  assuming the  obligations of the Company,  may, in its  discretion,
take any one or more of the following actions, as to outstanding options: (i) in
the event of a merger  under the terms of which  holders of the Common  Stock of
the Company will receive upon consummation thereof a cash payment for each share
surrendered in the merger (the

                                                                               
                                      -10-





"Merger  Price"),  make or provide for a cash payment to the optionees  equal to
the difference between (A) the Merger Price times the number of shares of Common
Stock subject to such  outstanding  options (to the extent then  exercisable  at
prices not in excess of the Merger Price) and (B) the aggregate  exercise  price
of all such outstanding options in exchange for the termination of such options,
and (ii) in the event the provisions of Section 15 are not  applicable,  provide
that all or any outstanding options shall become exercisable in full immediately
prior to such event and upon written notice to the  optionees,  provide that all
unexercised options will terminate immediately prior to the consummation of such
transaction unless exercised by the optionee within a specified period following
the date of such notice.

              (b)  Substitute  Options.  The Company may grant options under the
Plan in  substitution  for options held by employees of another  corporation who
become employees of the Company,  or a subsidiary of the Company,  as the result
of a merger or consolidation of the employing  corporation with the Company or a
subsidiary of the Company,  or as a result of the acquisition by the Company, or
one of its subsidiaries,  of property or stock of the employing corporation. The
Company  may  direct  that  substitute  options  be  granted  on such  terms and
conditions as the Board of Directors considers appropriate in the circumstances.

17.           No Special Employment Rights.

              Nothing  contained  in the Plan or in any option shall confer upon
any optionee any right with respect to the continuation of his or her employment
by the Company or interfere in any way with the right of the Company at any time
to terminate such employment or to increase or decrease the  compensation of the
optionee.

18.           Other Employee Benefits.

              Except as to plans which by their terms  include  such  amounts as
compensation,  the  amount  of any  compensation  deemed  to be  received  by an
employee as a result of the exercise of an option or the sale of shares received
upon such exercise will not  constitute  compensation  with respect to which any
other  employee  benefits of such employee are  determined,  including,  without
limitation, benefits under any bonus, pension, profit-sharing, life insurance or
salary  continuation  plan, except as otherwise  specifically  determined by the
Board of Directors.

19.           Amendment of the Plan.

              (a) The Board of Directors may at any time, and from time to time,
modify or amend the Plan in any respect; provided,  however, that if at any time
the approval of the stockholders of the Company is required under Section 422 of
the Code or any successor  provision with respect to Incentive Stock Options, or
under Rule 16b-3,  the Board of Directors  may not effect such  modification  or
amendment without such approval;  and provided,  further, that the provisions of
Section 3(c) hereof shall not be amended more than once every six months,

                                                                               
                                      -11-





other than to comport with changes in the Code, the Employer  Retirement  Income
Security Act of 1974, as amended, or the rules thereunder.

              (b) The  modification or amendment of the Plan shall not,  without
the consent of an optionee,  affect his or her rights under an option previously
granted to him or her. With the consent of the optionee  affected,  the Board of
Directors may amend  outstanding  option agreements in a manner not inconsistent
with the Plan.  The Board of  Directors  shall have the right to amend or modify
(i) the terms and provisions of the Plan and of any outstanding  Incentive Stock
Options  granted  under the Plan to the extent  necessary  to qualify any or all
such options for such favorable federal income tax treatment (including deferral
of taxation  upon  exercise) as may be afforded  incentive  stock  options under
Section 422 of the Code and (ii) the terms and provisions of the Plan and of any
outstanding  option to the extent  necessary to ensure the  qualification of the
Plan under Rule 16b-3.

20.           Withholding.

              (a) The Company  shall have the right to deduct  from  payments of
any kind otherwise due to the optionee any federal,  state or local taxes of any
kind  required  by law to be  withheld  with  respect to any shares  issued upon
exercise  of  options  under the Plan.  Subject  to the  prior  approval  of the
Company,  which may be  withheld  by the  Company  in its sole  discretion,  the
optionee  may elect to satisfy  such  obligations,  in whole or in part,  (i) by
causing  the  Company to  withhold  shares of Common  Stock  otherwise  issuable
pursuant  to the  exercise  of an option or (ii) by  delivering  to the  Company
shares of Common Stock already owned by the optionee. The shares so delivered or
withheld shall have a Fair Market Value equal to such withholding  obligation as
of the date  that the  amount  of tax to be  withheld  is to be  determined.  An
optionee  who has made an  election  pursuant  to this  Section  20(a)  may only
satisfy his or her withholding  obligation with shares of Common Stock which are
not subject to any repurchase,  forfeiture, unfulfilled vesting or other similar
requirements.

              (b) The  acceptance  of shares of Common Stock upon exercise of an
Incentive  Stock  Option  shall  constitute  an agreement by the optionee (i) to
notify the Company if any or all of such shares are  disposed of by the optionee
within two years  from the date the  option was  granted or within one year from
the date the shares were issued to the optionee  pursuant to the exercise of the
option, and (ii) if required by law, to remit to the Company, at the time of and
in the case of any  such  disposition,  an  amount  sufficient  to  satisfy  the
Company's  federal,  state and local withholding tax obligations with respect to
such  disposition,  whether or not, as to both (i) and (ii),  the optionee is in
the employ of the Company at the time of such disposition.

              (c)  Notwithstanding  the  foregoing,  in the case of a  Reporting
Person whose  options have been granted in  accordance  with the  provisions  of
Section  3(b) herein,  no election to use shares for the payment of  withholding
taxes  shall  be  effective  unless  made  in  compliance  with  any  applicable
requirements of Rule 16b-3.


                                                                               
                                      -12-





21.           Cancellation and New Grant of Options, Etc.

              The Board of Directors shall have the authority to effect,  at any
time and from time to time, with the consent of the affected optionees,  (i) the
cancellation of any or all  outstanding  options under the Plan and the grant in
substitution  therefor  of new  options  under  the  Plan  covering  the same or
different  numbers of shares of Common Stock and having an option exercise price
per share which may be lower or higher than the exercise  price per share of the
cancelled  options or (ii) the amendment of the terms of any and all outstanding
options  under the Plan to provide an option  exercise  price per share which is
higher  or  lower  than  the  then-current  exercise  price  per  share  of such
outstanding options.

22.           Effective Date and Duration of the Plan.

              (a) Effective  Date. The Plan shall become  effective when adopted
by the Board of Directors,  but no Incentive Stock Option granted under the Plan
shall become  exercisable  unless and until the Plan shall have been approved by
the Company's stockholders.  If such stockholder approval is not obtained within
twelve  months  after the date of the Board's  adoption of the Plan,  no options
previously  granted under the Plan shall be deemed to be Incentive Stock Options
and no Incentive  Stock Options shall be granted  thereafter.  Amendments to the
Plan not requiring  stockholder  approval shall become effective when adopted by
the Board of Directors;  amendments requiring  stockholder approval (as provided
in Section 21) shall become  effective  when adopted by the Board of  Directors,
but no Incentive  Stock Option  granted after the date of such  amendment  shall
become  exercisable  (to the extent that such amendment to the Plan was required
to enable the  Company  to grant such  Incentive  Stock  Option to a  particular
optionee)  unless  and until such  amendment  shall  have been  approved  by the
Company's  stockholders.  If such  stockholder  approval is not obtained  within
twelve months of the Board's  adoption of such  amendment,  any Incentive  Stock
Options  granted on or after the date of such amendment  shall  terminate to the
extent  that such  amendment  to the Plan was  required to enable the Company to
grant such option to a particular optionee. Subject to this limitation,  options
may be granted  under the Plan at any time after the  effective  date and before
the date fixed for termination of the Plan.

              (b)  Termination.  Unless sooner  terminated  in  accordance  with
Section  16,  the Plan  shall  terminate  upon the  earlier  of (i) the close of
business  on the day next  preceding  the tenth  anniversary  of the date of its
adoption  by the  Board of  Directors,  or (ii) the  date on  which  all  shares
available  for  issuance  under the Plan shall have been issued  pursuant to the
exercise  or  cancellation  of options  granted  under the Plan.  If the date of
termination is determined under (i) above, then options outstanding on such date
shall continue to have force and effect in accordance with the provisions of the
instruments evidencing such options.

23.           Provision for Foreign Participants.

              The Board of Directors  may,  without  amending  the Plan,  modify
awards or options granted to participants who are foreign  nationals or employed
outside the United States

                                                                                
                                      -13-





to recognize differences in laws, rules,  regulations or customs of such foreign
jurisdictions  with respect to tax,  securities,  currency,  employee benefit or
other matters.

24.           Governing Law.

              The  provisions  of this Plan shall be governed  and  construed in
accordance  with  the  laws of the  State  of  Delaware  without  regard  to the
principles of conflicts of laws.

              Adopted by the Board of Directors on September  23, 1994;  amended
by the Board of Directors December 18, 1996.



                                                                               
                                      -14-




                                                                   EXHIBIT  23.1


                       CONSENT OF INDEPENDENT ACCOUNTANTS

                  We  consent  to  the   incorporation   by  reference  in  this
Registration Statement of Interneuron  Pharmaceuticals,  Inc. on Form S-8 of our
report  dated  November  8,  1996 on our  audits of the  consolidated  financial
statements  of  Interneuron  Pharmaceuticals,  Inc. as of September 30, 1996 and
1995 and for the three years in the period ended  September 30, 1996,  appearing
in the Annual  Report on Form 10-K for the fiscal year ended  September 30, 1996
(SEC File No. 0- 18728) of  Interneuron  Pharmaceuticals,  Inc.  filed  with the
Securities and Exchange  Commission  pursuant to the Securities  Exchange Act of
1934, as amended.


                                                        COOPERS & LYBRAND L.L.P.

Boston, Massachusetts
April 9, 1997


                                                                               


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