INTERNEURON PHARMACEUTICALS INC
SC 13D/A, 1998-01-08
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                                        
                          (Amendment No. 21)**
                          --------------------



                        Interneuron Pharmaceuticals, Inc.
              -----------------------------------------------------
                                (Name of Issuer)

                          Common Stock, $.001 par value
            --------------------------------------------------------
                         (Title of Class of Securities)

                                  460573108
           ----------------------------------------------------------
                                 (CUSIP Number)

                Nadine Shaoul, D.H. Blair Investment Banking Corp.
                44 Wall Street, New York, NY  10005 (212) 495-4163
         ------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                 Authorized to Receive Notices and Communications)

                                 December 30, 1997
          -----------------------------------------------------------
            (Date of Event which Requires FIling of this Statement)


If the filing  person has  previously  filed a statement on Schedule 13G to
report the acquisition  which is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1(b) (3) or (4), check the following box [ ].

 
Check the following box if a fee is being paid with this statement [ ].(A fee
is not required only if the reporting person:  (1) has a previous  statement
on file reporting beneficial ownership of more than five percent of the class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting beneficial ownership of five percent or less of such class.)
(See Rule 13d-7.)

Note: Six copies of this statement, including all exhibits, should be filed
with the Commission.  See Rule 13d-1(a) for other parties to whom copies are
to be sent.


*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                             Page 1 of 4 pages
_________________________
** This Amendment is filed solely to amend Item 5. (c) of the previously
filed Schedule 13D, Amendment No. 20.
                         

<PAGE>

CUSIP No.  460573108                 13D                   Page 2 of 4 Pages



- --------------------------------------------------------------------------------
   1   NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       J. Morton Davis


- --------------------------------------------------------------------------------
   2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                             (a)  [  ]
                                                             (b)  [  ]


- --------------------------------------------------------------------------------
   3   SEC USE ONLY


- -------------------------------------------------------------------------------
   4   Source of Funds

       See Item #3 herein.

- -------------------------------------------------------------------------------
   5   Check Box if Disclosure of Legal Proceedings is required pursuant to
       Items 2(d) or 2(e)


- -------------------------------------------------------------------------------
   6   CITIZENSHIP OR PLACE OF ORGANIZATION

       United States

- --------------------------------------------------------------------------------
   NUMBER OF      7    SOLE VOTING POWER
     SHARES            8,965,793
  BENEFICIALLY    --------------------------------------------------------------
    OWNED BY      8    SHARED VOTING POWER
      EACH             0
   REPORTING      --------------------------------------------------------------
     PERSON       9    SOLE DISPOSITIVE POWER
      WITH             8,965,793
                 --------------------------------------------------------------
                  10   SHARED DISPOSITIVE POWER
                       0
- --------------------------------------------------------------------------------
   11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      10,466,958
- --------------------------------------------------------------------------------
  12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                       
- --------------------------------------------------------------------------------
  13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                         25.5%
- --------------------------------------------------------------------------------
  14   TYPE OF REPORTING PERSON*
                    IN

- --------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT


<PAGE>

CUSIP No.  460573108                 13D           Page 3 of 4 Pages


 
- --------------------------------------------------------------------------------
   1   NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       D.H. Blair Investment Banking Corp.


- --------------------------------------------------------------------------------
   2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                             (a)  [  ]
                                                             (b)  [  ]


- --------------------------------------------------------------------------------
   3   SEC USE ONLY


- -------------------------------------------------------------------------------
   4   Source of Funds

       See Item #3 herein.

- -------------------------------------------------------------------------------
   5   Check Box if Disclosure of Legal Proceedings is required pursuant to
       Items 2(d) or 2(e)

       
- -------------------------------------------------------------------------------
   6   CITIZENSHIP OR PLACE OF ORGANIZATION

       Delaware

- --------------------------------------------------------------------------------
   NUMBER OF      7    SOLE VOTING POWER
     SHARES            0
  BENEFICIALLY    --------------------------------------------------------------
    OWNED BY      8    SHARED VOTING POWER
      EACH             8,711,337
   REPORTING      --------------------------------------------------------------
     PERSON       9    SOLE DISPOSITIVE POWER
      WITH             0
                  --------------------------------------------------------------
                  10   SHARED DISPOSITIVE POWER
                       8,711,337
- --------------------------------------------------------------------------------
   11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      8,711,337
- --------------------------------------------------------------------------------
  12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                      
- --------------------------------------------------------------------------------
  13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                    21.2%
- --------------------------------------------------------------------------------
  14   TYPE OF REPORTING PERSON*
                    BD

- --------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT
<PAGE>
                                                            Page 4 of 4 Pages

          J.  Morton  Davis and  D.H.  Blair  Investment  Banking  Corp.
          ("Blair Investment"), (together,  the "Reporting Parties") hereby
          amend the following  item in their statement on Schedule 13D relating
          to the  common  stock,  $.001  par  value  ("shares")  of  Interneuron
          Pharmaceuticals, Inc. (the "Issuer") as follows:

Item 5. (c) is hereby amended by deleting the first paragraph and substituting
         the following paragraph thereto:

          On December  30,  1997,  Blair  Investment  made gifts of 300,000
          shares,   100,000  shares,   100,000   shares,   and  100,000  shares,
          respectively,  to  each  of  four  charitable  foundations, the 
          trustees, officers and directors of which are various family
          members of J. Morton Davis.  Three of the four charitable foundations
          have given a proxy to vote and dispose of any shares held by them to a
          third party. J. Morton Davis expressly disclaims beneficial ownership
          of all securities held by these four charitable foundations for any
          purpose. No other transactions were made in the Issuer's shares by the
          Reporting Parties in the previous sixty days.



                                                 
                                                   

                                   SIGNATURES

 After reasonable inquiry and to the best of my knowledge and belief, we 
certify that the information set forth in this statement is true, complete 
and correct.


 
                                              /s/ J. Morton Davis
Date:    January 8, 1998                   _____________________________
         New York, New York                  J. Morton Davis
                                        




 


                                       D.H. BLAIR INVESTMENT BANKING CORP.


 
                                              /s/ David Nachamie
Date:    January 8, 1998                  by_____________________________
         New York, New York                     David Nachamie
                                                Treasurer




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