INTERNEURON PHARMACEUTICALS INC
SC 13G/A, 1998-02-11
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G
                                 (Rule 13d-102)

           INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO
   RULES 13D-1 (B) AND (C) AND AMENDMENTS THERETO FILED PURSUANT TO 13D-2(B)


                               (Amendment No. 1)(1)



                                Intercardia, Inc.
                ------------------------------------------------
                                (Name of Issuer)




                          Common Stock, $.001 par value
                ------------------------------------------------
                         (Title of Class of Securities)



                                   458 44M 106
                ------------------------------------------------
                                 (CUSIP Number)

                                ----------------


1 The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

<PAGE>   2
- ------------------------------                        -------------------------
CUSIP NO.  458 44M 106                 13G            PAGE    2   OF   5  PAGES
         ---------------------                              -----    -----      
- ------------------------------                        -------------------------

- -------------------------------------------------------------------------------
  (1)     NAME OF REPORTING PERSON                 
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

          Interneuron Phamaceuticals, Inc.
          04-3047911
- -------------------------------------------------------------------------------
  (2)     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*         (A)   [   ]
                                                                    (B)   [   ]

- ------------------------------------------------------------------------------- 
  (3)     SEC USE ONLY

- -------------------------------------------------------------------------------
  (4)     CITIZENSHIP OR PLACE OF ORGANIZATION                      
          Delaware
- -------------------------------------------------------------------------------
                       (5)     SOLE VOTING POWER                    
  NUMBER OF                    4,145,029 
   SHARES              --------------------------------------------------------
 BENEFICIALLY          (6)     SHARED VOTING POWER                  
  OWNED BY                     0
    EACH               --------------------------------------------------------
  REPORTING            (7)     SOLE DISPOSITIVE POWER               
 PERSON WITH                   4,145,029
                       --------------------------------------------------------
                       (8)     SHARED DISPOSITIVE POWER             
                               0
- -------------------------------------------------------------------------------
  (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON         
          4,145,029
- -------------------------------------------------------------------------------
 (10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
          SHARES*                                                         [   ]

- -------------------------------------------------------------------------------
 (11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9           
          61.2%
- -------------------------------------------------------------------------------
 (12)     TYPE OF REPORTING PERSON*
          CO
- -------------------------------------------------------------------------------

                    *SEE INSTRUCTIONS BEFORE FILLING OUT!



                  
                             
<PAGE>   3


                                                                     Page 3 of 5

Item 1(a).     Name of Issuer :

               Intercardia, Inc. (the "Issuer")

Item 1(b).     Address of Issuer's Principal Executive Offices:

               3200 Chapel Hill/Nelson Highway
               Cape Fear Building, Suite 101
               P.O. Box 14287
               Research Triangle Park, North Carolina 27709

Item 2(a).     Name of Person Filing:

               Interneuron Pharmaceuticals, Inc. ("IPI")

Item 2(b).     Address of Principal Business Office or if none, Residence:

               One Ledgemont Center
               99 Hayden Avenue
               Lexington, Massachusetts 02173

Item 2(c).     Citizenship:

               IPI is a corporation organized under the laws of the
               State of Delaware.

Item 2(d).     Title of Class of Securities:

               Common Stock, $.001 par value ("Shares")

Item 2(e).     CUSIP Number:

               458 44M 106

Item 3.        Not Applicable

Item 4.        Ownership as of December 31, 1997:

               (a)    IPI is the beneficial owner of 4,145,029 Shares.

               (b)    The 4,145,029 Shares beneficially owned by IPI constitute
                      61.2% of the Shares of the Issuer outstanding.

               (c)    (i)-(iv) Reference is made to items 5-8 of the cover page.


<PAGE>   4


                                                                     Page 4 of 5

Item 5.        Ownership of Five Percent or Less of a Class:

               Not Applicable

Item 6.        Ownership of More than Five Percent on Behalf of Another Person:

               Not Applicable

Item 7.        Identification and Classification of Subsidiary Which Acquired 
               the Securities:

               Not Applicable

Item 8.        Identification and Classification of Members of the Group:

               Not Applicable

Item 9.        Notice of Dissolution of Group:

               Not Applicable

Item 10.       Certification:

               Not Applicable

               

<PAGE>   5


                                                                     Page 5 of 5

                                   SIGNATURES

                  After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.

Dated:     February 10, 1998          Interneuron Pharmaceuticals, Inc.
           Lexington,
           Massachusetts

                                      By: /s/ Glenn L. Cooper, M.D.
                                         ---------------------------------------
                                         Glenn L. Cooper, M.D., President






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