INTERNEURON PHARMACEUTICALS INC
SC 13G/A, 1999-09-01
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                      SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, DC  20549

                                   _________

                                 SCHEDULE 13G
                                (Rule 13d-102)

            INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
          TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED
                           PURSUANT TO RULE 13d-2(b)
                              (AMENDMENT NO.3)/1/




                      Incara Pharmaceuticals Corporation
            -------------------------------------------------------
                               (Name of Issuer)


                         Common Stock, $.001 par value
            -------------------------------------------------------
                        (Title of Class of Securities)


                                  458 44M 106
            -------------------------------------------------------
                                (CUSIP Number)


                       July 15, 1999 and August 8, 1999
            -------------------------------------------------------
            (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

     [_] Rule 13d-1(b)

     [_] Rule 13d-1(c)

     [X] Rule 13d-1(d)


- --------------------
/1/  The remainder of this cover page shall be filled out for a reporting
 person's initial filing on this form with respect to the subject class of
 securities, and for any subsequent amendment containing information which would
 alter the disclosures provided in a prior cover page.

     The information required in the remainder of this cover page shall not be
 deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
 Act of 1934 or otherwise subject to the liabilities of that section of the Act
 but shall be subject to all other provisions of the Act (however, see the
 Notes).
<PAGE>

===============================================================================


  CUSIP NO.  458 44M 106                                      Page 2 of 5 Pages
             ---------

- -------------------------------------------------------------------------------
      NAMES OF REPORTING PERSONS.
 1    I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY).

      Interneuron Pharmaceuticals, Inc. 04-3047911

- ------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
 2                                                              (a) [_]
                                                                (b) [_]

- ------------------------------------------------------------------------------
      SEC USE ONLY
 3


- ------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
      Delaware

- ------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF            281,703

      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6
                          0
     OWNED BY
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING             281,703

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                          0
- ------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
      281,703
- ------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
10
                                                                    [_]

- ------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
11
      Approximately 7.1%

- ------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON
12
      CO

- ------------------------------------------------------------------------------
<PAGE>

                                                               Page 3 of 5 Pages

Item 1(a).  NAME OF ISSUER:

            Incara Pharmaceuticals Corporation
            ----------------------------------

Item 1(b).  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:

            P.O. Box 14287, 3200 East Highway 54,
            Cape Fear Building, Suite 300
            Research Triangle Park, NC  27709
            ---------------------------------

Item 2(a).  NAME OF PERSON FILING:

            Interneuron Pharmaceuticals, Inc. ("IPI")
            -----------------------------------------

Item 2(b).  ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:

            One Ledgemont Center, 99 Hayden Avenue, Lexington, MA 02421
            -----------------------------------------------------------

Item 2(c)  CITIZENSHIP:

            IPI is a corporation organized under the laws of the
            State of Delaware
            -----------------

Item 2(d)   TITLE OF CLASS OF SECURITIES:

            Common Stock, $.001 par value ("Shares")
            ----------------------------------------

Item 2 (e)  CUSIP NUMBER:

            458 44M 106
            -----------

Item 3.     IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), OR 13d-2(b) or
            (c), CHECK WHETHER THE PERSON FILING IS A:

          (a)  __   Broker or dealer registered under Section 15 of the Exchange
                    Act.
          (b)  __   Bank as defined in Section 3(a)(6) of the Exchange Act.
          (c)  __   Insurance company as defined in Section 3(a)(19) of the
                    Exchange Act.
          (d)  __   Investment company registered under Section 8 of the
                    Investment Company Act.
          (e)  __   An investment advisor in accordance with Rule 13d-
                    1(b)(1)(ii)(E);
          (f)  __   An employee benefit plan or endowment fund in accordance
                    with Rule 13d-1(b)(1)(ii)(F);
          (g)  __   A parent holding company or control person in accordance
                    with Rule 13d-1(b)(1)(ii)(G);
          (h)  __   A savings association as defined in Section 3(b) of the
                    Federal Deposit Insurance Act;
          (i)  __   A church plan that is excluded from the definition of an
                    investment company under Section 3(c)(14) of the Investment
                    Company Act of 1940;
          (j)  __   Group, in accordance with Rule 13d-1(b)(1)(ii)(J).
<PAGE>

                                                               Page 4 of 5 Pages

Item 4.  OWNERSHIP.

     Provide the following information regarding the aggregate number and
percentage of the class of securities of the issuer identified in Item 1.

     (a)  AMOUNT BENEFICIALLY OWNED:

          IPI is the beneficial owner of 281,703 Shares

     (b)  PERCENT OF CLASS:

          The 281,703 Shares beneficially owned by IPI constitute approximately
          7.1% of the Shares of the Issuer outstanding

     (c)  (i)-(iv):

          Reference is made to Items 5-8 of the cover page.

Item 5.   OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

     If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities, check the following [  ].

Item 6.   OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.

               Not Applicable

Item 7.   IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
          SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.

               Not Applicable

Item 8.   IDENTIFICATION AND CLASSIFICATION OF SUBSIDIARY WHICH ACQUIRED THE
          SECURITIES.

               Not Applicable

Item 9.   NOTICE OF DISSOLUTION OF GROUP.

               Not Applicable

Item 10.  CERTIFICATION.

               Not applicable.
<PAGE>

                                                               Page 5 of 5 Pages

                                   SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

                       September 1, 1999
                       -----------------
                       (Date)
                       INTERNEURON PHARMACEUTICALS, INC.


                       By: /s/ Glenn L. Cooper, M.D.
                       -----------------------------
                       Glenn L. Cooper, M.D., President

     The original statement shall be signed by each person on whose behalf the
statement is filed or his authorized representative.  If the statement is signed
on behalf of a person by his authorized representative (other than an executive
officer or general partner of the filing person), evidence of the
representative's authority to sign on behalf of such person shall be filed with
the statement, provided, however, that a power of attorney for this purpose
which is already on file with the Commission may be incorporated by reference.
The name and any title of each person who signs the statement shall be typed or
printed beneath his signature.


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