ARONEX PHARMACEUTICALS INC
S-8, 1996-12-31
PHARMACEUTICAL PREPARATIONS
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    As filed with the Securities and Exchange Commission on December 31, 1996
                                                      Registration No. 333-
- --------------------------------------------------------------------------------

- --------------------------------------------------------------------------------


                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                           ---------------------------


                                    FORM S-8

                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                          ARONEX PHARMACEUTICALS, INC.
             (Exact name of registrant as specified in its charter)


               Delaware                                      76-0196535
    (State or other jurisdiction of                       (I.R.S. Employer
    incorporation or organization)                      Identification No.)

      3400 Research Forest Drive
         The Woodlands, Texas                                  77381
(Address of Principal Executive Offices)                     (Zip Code)

                        1997 EMPLOYEE STOCK PURCHASE PLAN
                            (Full title of the plan)

                              James M. Chubb, Ph.D.
                          Aronex Pharmaceuticals, Inc.
                           3400 Research Forest Drive
                           The Woodlands, Texas 77381
                     (Name and address of agent for service)

                                 (281) 367-1666
          (Telephone number, including area code, of agent for service)

                           ---------------------------

                                    copy to:
                                 Jeffrey L. Wade
                             Andrews & Kurth L.L.P.
                        2170 Buckthorne Place, Suite 150
                           The Woodlands, Texas 77380
                                 (713) 220-4801

                           ---------------------------


                         CALCULATION OF REGISTRATION FEE
<TABLE>
<CAPTION>


                                                          Proposed Maximum    Proposed Maximum
                                            Amount to      Offering Price        Aggregate             Amount of
Title of Securities to be Registered      be Registered     Per Share(1)      Offering Price(1)     Registration Fee
<S>                                      <C>              <C>              <C>                   <C>   
- ---------------------------------------- ---------------  ---------------- --------------------  --------------------
Common Stock, par value $0.001 per share  250,000 Shares        $9.75         $2,437,500               $739
======================================== ===============  ================ ====================  ====================
</TABLE>

(1)      Estimated  solely  for the  purpose  of  calculating  the amount of the
         registration  fee,  based  upon the  average of the high and low prices
         reported on The Nasdaq National Market of the Registrant's Common Stock
         on December 27, 1996, pursuant to Rule 457(c) and (h).
================================================================================



<PAGE>

                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE.

          Aronex  Pharmaceuticals,  Inc. (the "Company")  incorporates herein by
reference the following documents as of their respective dates as filed with the
Securities and Exchange Commission (the "Commission"):

          1. The  Company's  Annual  Report  on Form  10-K  for the  year  ended
     December 31, 1995, as amended.

          2. The Company's Quarterly Reports on Form 10-Q for the quarters ended
     March 31, 1996, June 30, 1996, and September 30, 1996.

          3. The  description  of the Common Stock  contained  in the  Company's
     Registration  Statement  on Form 8-A filed April 23,  1992,  including  any
     amendments and reports filed for the purpose of updating such description.

         All documents filed by the Company  pursuant to Sections 13(a),  13(c),
14 and 15(d) of the Exchange Act after the date of this  Registration  Statement
and prior to the filing of a  post-effective  amendment which indicates that all
securities  offered  hereby  have  been  sold  or  which  deregisters  all  such
securities then remaining unsold shall be deemed to be incorporated by reference
in this  Registration  Statement and to be a part hereof from the date of filing
such documents.

ITEM 4. DESCRIPTION OF SECURITIES.

         The  information   required  by  Item  4  is  not  applicable  to  this
registration statement since the class of securities to be offered is registered
under Section 12 of the Exchange Act.

ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL.

         The  information   required  by  Item  5  is  not  applicable  to  this
registration statement.

ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS.

         Section 145 of the Delaware  General  Corporation  Law ("DGCL"),  inter
alia,  empowers a Delaware  corporation  to indemnify any person who was or is a
party  or is  threatened  to be  made a  party  to any  threatened,  pending  or
completed action, suit or proceeding (other than an action by or in the right of
the  corporation)  by reason of the fact that such  person is or was a director,
officer,  employee  or agent of the  corporation,  or is or was  serving  at the
request of the corporation as a director,  officer, employee or agent of another
corporation or other enterprise,  against expenses (including  attorneys' fees),
judgments, fines and amounts paid in settlement actually and reasonably incurred
by him in  connection  with such action,  suit or proceeding if he acted in good
faith and in a manner he reasonably believed to be in or not opposed to the best
interests  of the  corporation,  and,  with  respect to any  criminal  action or
proceeding, had no reasonable cause to believe his conduct was unlawful. Similar
indemnity is authorized for such persons against expenses (including  attorneys'
fees)  actually  and  reasonably  incurred  in  connection  with the  defense or
settlement of any such  threatened,  pending or completed action or suit if such
person  acted in good faith and in a manner he  reasonably  believed to be in or
not opposed to the best interests of the corporation,  and provided further that
(unless a court of competent  jurisdiction otherwise provides) such person shall
not have been adjudged liable to the corporation.  Any such  indemnification may
be made only as authorized in each  specific  case upon a  determination  by the
stockholders  or  disinterested  directors or by independent  legal counsel in a
written  opinion that  indemnification  is proper because the indemnitee has met
the applicable standard of conduct.

         Section 145 further  authorizes a corporation  to purchase and maintain
insurance on behalf of any person who is or was a director, officer, employee or
agent of the corporation, or is or was serving at the request of the corporation
as a director,  officer, employee or agent of another corporation or enterprise,
against  any  liability  asserted  against  him and  incurred by him in any such
capacity,  or arising out of his status as such,  whether or not the corporation
would  otherwise  have the power to indemnify him under Section 145. The Company
maintains  policies  insuring its and its  subsidiaries' 

                                      II-1

<PAGE>


officers and directors  against  certain  liabilities  for actions taken in such
capacities,  including  liabilities under the Securities Act of 1933, as amended
(the "Securities Act").

         Article VIII of the Amended and Restated  Certificate of  Incorporation
of the  Company  and  Article  VII of the  Bylaws  of the  Company  provide  for
indemnification  of the directors of the Company to the full extent permitted by
law, as now in effect or later  amended.  Article VII of the Bylaws also permits
the  indemnification to the same extent of officers,  employees or agents of the
Company  if,  and to the  extent,  authorized  by the  Board  of  Directors.  In
addition, the Bylaws provide for indemnification  against expenses incurred by a
director to be paid by the  Company at  reasonable  intervals  in advance of the
final  disposition  of  such  action,  suit or  proceeding  upon  receipt  of an
undertaking  by or on behalf of the  director or officer to repay such amount if
it shall be ultimately  determined  that he is not entitled to be indemnified by
the Company. The Bylaws further provide for a contractual cause of action on the
part of directors of the Company for  indemnification  claims that have not been
paid by the Company.

         The Company also has provided liability insurance for each director and
officer for certain  losses  arising  from claims or charges  made  against them
while acting in their capacities as directors or officers of the Company.

         Article  VII of the  Company's  Amended  and  Restated  Certificate  of
Incorporation,  as amended,  limits under certain circumstances the liability of
the Company's directors for a breach of their fiduciary duty as directors. These
provisions  do not eliminate the liability of a director (i) for a breach of the
director's duty of loyalty to the Company or its stockholders,  (ii) for acts or
omissions not in good faith or that involve intentional  misconduct or a knowing
violation  of  law,  (iii)  under  Section  174 of  the  DGCL  (relating  to the
declaration  of dividends  and purchase or  redemption of shares in violation of
the  DGCL) or (iv) for any  transaction  from  which  the  director  derived  an
improper personal benefit.

ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED.

         Information  required by Item 7 is not applicable to this  Registration
Statement.


                                      II-2

<PAGE>



ITEM 8. EXHIBITS.

Exhibit
Number                             Description

4.1       Amended and Restated Certificate of Incorporation, as amended. Exhibit
          3.1 to the Company's  Quarterly  Report on Form 10-Q for the quarterly
          period ended June 30, 1996 is incorporated herein by reference.

4.2       Restated Bylaws.  Exhibit 3.2 to the Company's  Registration Statement
          on Form S-1 (No.  33-47418),  declared  effective by the Commission on
          July 10, 1992, is incorporated herein by reference.

4.3       Specimen  certificate for shares of Common Stock,  par value $.001 per
          share.  Exhibit 4.1 to the Company's Quarterly Report on Form 10-Q for
          the  quarterly  period ended June 30, 1996 is  incorporated  herein by
          reference.

5.1*      Opinion  of  Andrews  &  Kurth  L.L.P.,  as to  the  legality  of  the
          securities being registered.

23.1*     Consent of Arthur Andersen LLP

23.2*     Consent of Andrews & Kurth L.L.P.  (included  in the opinion  filed as
          Exhibit 5.1 to this Registration Statement).

24.1*     Power of Attorney (set forth on the signature  page  contained in Part
          II of this Registration Statement).

99.1*     Aronex Pharmaceuticals, Inc. 1997 Employee Stock Purchase Plan

- ---------------------------
*Filed with this Registration Statement.

ITEM 9. UNDERTAKINGS.

         The undersigned Registrant hereby undertakes:

         (a)      The undersigned Registrant hereby undertakes:

                  (1) To file,  during any  period in which  offers or sales are
         being made, a post-effective amendment to this registration statement:

                    (i) To include any prospectus  required by Section  10(a)(3)
               of the Securities Act of 1933; 

                    (ii) To  reflect  in the  prospectus  any  facts  or  events
               arising after the effective  date of the  registration  statement
               (or the most  recent  post-effective  amendment  thereof)  which,
               individually or in the aggregate,  represent a fundamental change
               in the  information  set  forth  in the  registration  statement.
               Notwithstanding the foregoing, any increase or decrease in volume
               of  securities  offered (if the total dollar value of  securities
               offered  would not  exceed  that  which was  registered)  and any
               deviation  from  the low or  high  end of the  estimated  maximum
               offering  range may be reflected in the form of prospectus  filed
               with the Commission pursuant to Rule 424(b) if, in the aggregate,
               the  changes  in  volume  and price  represent  no more than a 20
               percent change in the maximum aggregate  offering price set forth
               in the  "Calculation of Registration  Fee" table in the effective
               registration statement;


                    (iii) To include any  material  information  with respect to
               the  plan  of  distribution  not  previously   disclosed  in  the
               registration statement or any material change to such information
               in the registration statement;


                                       II-3

<PAGE>


                  Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do
         not apply if the  registration  statement  is on Form S-3,  Form S-8 or
         Form  F-3,   and  the   information   required  to  be  included  in  a
         post-effective  amendment by those  paragraphs is contained in periodic
         reports  filed with or furnished to the  Commission  by the  Registrant
         pursuant to Section 13 or Section  15(d) of the  Exchange  Act that are
         incorporated by reference in the registration statement.

                  (2) That, for the purpose of determining  any liability  under
         the Securities Act, each such post-effective  amendment shall be deemed
         to be a new registration  statement  relating to the securities offered
         therein,  and the  offering  of such  securities  at that time shall be
         deemed to be the initial bona fide offering thereof.

                  (3) To remove from  registration by means of a  post-effective
         amendment any of the securities being registered which remain unsold at
         the termination of the offering.

                  (b) The undersigned  registrant  hereby  undertakes  that, for
purposes of determining  any liability  under the  Securities Act of 1933,  each
filing of the  registrant's  annual report pursuant to Section 13(a) or 15(d) of
the Securities  Exchange Act of 1934 that is  incorporated  by reference in this
Registration  Statement  shall  be  deemed  to be a new  registration  statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

                  (c) Insofar as indemnification  for liabilities  arising under
the  Securities  Act of  1933  may  be  permitted  to  directors,  officers  and
controlling persons of the registrant pursuant to the foregoing  provisions,  or
otherwise, the registrant has been advised that in the opinion of the Securities
and  Exchange  Commission  such  indemnification  is  against  public  policy as
expressed in the Securities Act of 1933 and is, therefore, unenforceable. In the
event that a claim for indemnification  against such liabilities (other than the
payment by the registrant of expenses incurred or paid by a director, officer or
controlling  person of the registrant in the  successful  defense of any action,
suit or proceeding) is asserted by such director,  officer or controlling person
in connection with the securities being registered,  the registrant will, unless
in the  opinion  of its  counsel  the matter  has been  settled  by  controlling
precedent,  submit to a court of appropriate  jurisdiction  the question whether
such  indemnification  by it is  against  public  policy  as  expressed  in  the
Securities  Act of 1933 and will be governed by the final  adjudication  of such
issue.


                                      II-4

<PAGE>


                                   SIGNATURES

         Pursuant to the  requirements  of the Securities  Exchange Act of 1933,
the Registrant certifies that is has reasonable grounds to believe that it meets
all of the  requirements  for  filing  on  Form  S-8 and has  duly  caused  this
Registration Statement to be signed on its behalf by the undersigned,  thereunto
duly authorized,  in The Woodlands,  State of Texas on the 30th day of December,
1996.

                                         ARONEX PHARMACEUTICALS, INC.

                                         By:      /s/ James M. Chubb
                                            --------------------------------
                                                  James M. Chubb
                                                  President

         KNOW ALL MEN BY THESE PRESENTS,  that each of the undersigned  officers
and directors of Aronex Pharmaceuticals, Inc. (the "Company") hereby constitutes
and appoints James M. Chubb and Terance A. Murnane, or either of them (with full
power to each of them to act alone),  his true and lawful  attorney-in-fact  and
agent,  with full power of substitution and  resubstitution,  for him and on his
behalf and in his name,  place and stead,  in any and all  capacities,  to sign,
execute and file this  Registration  Statement under the Securities Act of 1933,
as  amended,  and  any  or  all  amendments   (including,   without  limitation,
post-effective amendments), with all exhibits and any and all documents required
to be filed with respect thereto, with the Securities and Exchange Commission or
any regulatory authority,  granting unto such  attorneys-in-fact and agents, and
each of them acting  alone,  full power and authority to do and perform each and
every act and thing requisite and necessary to be done in and about the premises
in order to  effectuate  the same,  as fully to all intents  and  purposes as he
himself might or could do if personally present, hereby ratifying and confirming
all that such  attorneys-in-fact and agents, or any of them, or their substitute
or substitutes, may lawfully do or cause to be done.

         PURSUANT  TO THE  REQUIREMENTS  OF THE  SECURITIES  ACT OF  1933,  THIS
REGISTRATION  STATEMENT  HAS  BEEN  SIGNED  BY  THE  FOLLOWING  PERSONS  IN  THE
CAPACITIES AND ON THE DATES INDICATED.

<TABLE>
<CAPTION>

Signature                                   Title                                        Date
- ---------                                   -----                                        ----
<S>                               <C>                                            <C>   

/s/ James M. Chubb                President and Director                         December 30, 1996
- -----------------------------     (Principal Executive Officer)                         
James M. Chubb                  

/s/ Terance A. Murnane            Controller                                     December 30, 1996
- -----------------------------     (Principal Financial and Accounting Officer)
Terance A. Murnane              

/s/ Martin P. Sutter              Chairman of the Board of Directors             December 30, 1996
- -----------------------------
Martin P. Sutter                
                                  Director                                       December   , 1996
- -----------------------------                                               
Gabriel Lopez-Berestein
                                  Director                                       December   , 1996 
- ----------------------------- 
Donald J. Brenner                                            

/s/ Geoffrey F. Cox               Director                                       December 30, 1996        
- -----------------------------                                               
Geoffrey F. Cox

/s/ George B. Mackaness           Director                                       December 30, 1996     
- -----------------------------    
George B. Mackaness
                                  Director                                       December   , 1996
- -----------------------------                                                    
Gregory F. Zaic

</TABLE>

                                      II-5

<PAGE>



                                  EXHIBIT INDEX

Exhibit
Number                             Description

4.1       Amended and Restated Certificate of Incorporation, as amended. Exhibit
          3.1 to the Company's  Quarterly  Report on Form 10-Q for the quarterly
          period ended June 30, 1996 is incorporated herein by reference.

4.2       Restated Bylaws.  Exhibit 3.2 to the Company's  Registration Statement
          on Form S-1 (No.  33-47418),  declared  effective by the Commission on
          July 10, 1992, is incorporated herein by reference.

4.3       Specimen  certificate for shares of Common Stock,  par value $.001 per
          share.  Exhibit 4.1 to the Company's Quarterly Report on Form 10-Q for
          the  quarterly  period ended June 30, 1996 is  incorporated  herein by
          reference.

5.1*      Opinion  of  Andrews  &  Kurth  L.L.P.,  as to  the  legality  of  the
          securities
          being registered.

23.1*     Consent of Arthur Andersen LLP

23.2*     Consent of Andrews & Kurth L.L.P.  (included  in the opinion  filed as
          Exhibit 5.1 to this Registration Statement).

24.1*     Powerof Attorney (set forth on the signature  page  contained in Part
          II of this Registration Statement).

99.1* Aronex Pharmaceuticals, Inc. 1997 Employee Stock Purchase Plan

- ---------------------------
*Filed with this Registration Statement.




                                                                  EXHIBIT 5.1


                                                    December 31, 1996



Board of Directors
Aronex Pharmaceuticals, Inc.
3400 Research Forest Drive
The Woodlands, Texas 77381

Ladies and Gentlemen:

                  We have acted as counsel to Aronex Pharmaceuticals,  Inc. (the
"Company") in connection with the Company's  Registration  Statement on Form S-8
(the "Registration Statement") relating to the registration under the Securities
Act of 1933, as amended,  of the issuance of up to 250,000 shares (the "Shares")
of the Company's common stock,  $0.001 par value (the "Common Stock"),  pursuant
to the Aronex  Pharmaceuticals,  Inc.  1997  Employee  Stock  Purchase Plan (the
"Plan").

                  In  connection  herewith,  we  have  examined  copies  of such
statutes, regulations,  corporate records and documents,  certificates of public
and  corporate  officials  and  other  agreements,   contracts,   documents  and
instruments  as we have deemed  necessary  as a basis for the opinion  hereafter
expressed.  In  such  examination,  we  have  assumed  the  genuineness  of  all
signatures,  the authenticity of all documents  submitted to us as originals and
the conformity with the original  documents of all documents  submitted to us as
copies.  We have also relied,  to the extent we deem such reliance proper,  upon
information  supplied by officers  and  employees of the Company with respect to
various factual matters material to our opinion.

                  Based upon the  foregoing and having due regard for such legal
considerations  as we deem relevant,  we are of the opinion that the Shares have
been duly authorized,  and that such Shares will, when issued in accordance with
the terms of the Plan, be legally issued, fully paid and nonassessable.

                  We hereby  consent to the use of this opinion as an exhibit to
the Registration Statement.

                                                     Very truly yours,

                                                     ANDREWS & KURTH L.L.P.

2365/1096





                                                              EXHIBIT 23.2

                       CONSENT OF INDEPENDENT ACCOUNTANTS

         As   independent   public   accountants,   we  hereby  consent  to  the
incorporation by reference in this Registration  Statement on Form S-8 of Aronex
Pharmaceuticals,  Inc.  of our report  dated  March 7, 1996  included  in Aronex
Pharmaceuticals, Inc.'s Form 10-K/A for the year ended December 31, 1995.


ARTHUR ANDERSEN LLP



The Woodlands, Texas
December 31, 1996





                                                                  EXHIBIT 99.1


                          ARONEX PHARMACEUTICALS, INC.

                        1997 EMPLOYEE STOCK PURCHASE PLAN


1.       PURPOSE.

         (a) The purpose of the Aronex Pharmaceuticals, Inc. 1997 Employee Stock
Purchase  Plan (the  "Plan") is to provide a means by which  employees of Aronex
Pharmaceuticals,   Inc.,  a  Delaware  corporation  (the  "Company"),   and  its
"Affiliates" (as defined in subparagraph 1(b)), which are designated as provided
in  subparagraph  2(b),  may be given an  opportunity  to purchase  stock of the
Company.

         (b)  The  word  "Affiliate"  as  used  in the  Plan  means  any  parent
corporation or subsidiary corporation of the Company, as those terms are defined
in Sections 424(e) and (f), respectively,  of the Internal Revenue Code of 1986,
as amended (the "Code").

         (c) The Company,  by means of the Plan, seeks to retain the services of
its  employees,  to secure and  retain the  services  of new  employees,  and to
provide  incentives for such persons to exert maximum efforts for the success of
the Company.

         (d) The  Company  intends  that the  rights  to  purchase  stock of the
Company  granted under the Plan be considered  options issued under an "employee
stock purchase plan" as that term is defined in Section 423(b) of the Code.

2.       ADMINISTRATION.

         (a) The Plan  shall be  administered  by the  Board of  Directors  (the
"Board") of the Company unless and until the Board delegates  administration  of
the Plan to a committee,  as provided in Subparagraph  2(c).  Whether or not the
Board has delegated  administration of the Plan to a committee,  the Board shall
have the final power to determine  all questions of policy and  expediency  that
may arise in the administration of the Plan.

          (b) The Board  shall  have the  power,  subject  to,  and  within  the
limitations of, the express provisions of the Plan:

                    (i) to  determine  when and how rights to purchase  stock of
               the Company shall be granted and the  provisions of each offering
               of such rights (which need not be identical);

                    (ii) to designate from time to time which  Affiliates of the
               Company shall be eligible to participate in the Plan;

                    (iii) to construe and interpret the Plan and rights  granted
               under  it,  and  to   establish,   amend  and  revoke  rules  and
               regulations for its administration. The Board, in the exercise of
               this power, may correct any defect,  omission or inconsistency in
               the Plan,  in a manner and to the extent it shall deem  necessary
               or expedient to make the Plan fully effective;

                    (iv) to amend the Plan as provided in paragraph 13; and

                    (v)  generally,  to exercise such powers and to perform such
               acts as the Board deems  necessary,  or  expedient to promote the
               best interests of the Company.

          (c) The Board may delegate  administration  of the Plan to a committee
composed  of not fewer than two (2) members of the Board (the  "Committee").  If
administration  of the Plan is delegated to the Committee,  the Committee  shall
have, in connection with the  administration of the Plan, the powers theretofore
possessed by the Board, subject, however, to such resolutions,  not inconsistent
with the  provisions  of the Plan,  as may be  adopted  from time to time by the
Board.  The Board may abolish the  Committee at any time and revest in the Board
the administrative duties of the Plan.



<PAGE>

3.       SHARES SUBJECT TO THE PLAN.

         (a) Subject to the  provisions of paragraph 12 relating to  adjustments
upon  changes in stock,  the stock that may be sold  pursuant to rights  granted
under the Plan shall not exceed in the  aggregate  two  hundred  fifty  thousand
(250,000)  shares of the  Company's  common stock (the "Common  Stock").  If any
right granted under the Plan shall for any reason terminate  without having been
exercised,  the Common Stock not  purchased  under such right shall again become
available for the Plan.

          (b) The stock subject to the Plan may be unissued shares or reacquired
shares, bought on the market or otherwise.

4.       GRANT OF RIGHTS; OFFERING.

         The Board or the  Committee  may from time to time grant or provide for
the grant of rights to purchase  Common  Stock of the Company  under the Plan to
eligible  employees (an "Offering") on a date or dates (the "Offering  Date(s)")
selected by the Board or the Committee.  Each Offering shall be in such form and
shall contain such terms and conditions as the Board or the Committee shall deem
appropriate.  If an employee has more than one right outstanding under the Plan,
unless  he or  she  otherwise  indicates  in  agreements  or  notices  delivered
hereunder:  (1) each  agreement  or notice  delivered by that  employee  will be
deemed to apply to all of his or her rights under the Plan, and (2) a right with
a  lower  exercise  price  (or an  earlier-granted  right,  if two  rights  have
identical  exercise  prices) will be exercised  to the fullest  possible  extent
before a right with a higher  exercise price (or a  later-granted  right, if two
rights have  identical  exercise  prices) will be exercised.  The  provisions of
separate  Offerings  need not be  identical,  but each  Offering  shall  include
(through  incorporation  of the  provisions  of this  Plan by  reference  in the
Offering or otherwise) the substance of the provisions contained in paragraphs 5
through 8, inclusive.

5.       ELIGIBILITY.

         (a) Rights may be granted  only to  employees of the Company or, as the
Board or the  Committee  may  designate  as provided in  subparagraph  2(b),  to
employees of any  Affiliate of the Company.  Except as provided in  subparagraph
5(b),  an employee of the Company or any  Affiliate  shall not be eligible to be
granted rights under the Plan,  unless,  on the Offering Date, such employee has
been in the employ of the Company or any  Affiliate for such  continuous  period
preceding such grant as the Board or the Committee may require,  but in no event
shall the required  period of continuous  employment be equal to or greater than
two (2) years.  In addition,  unless  otherwise  determined  by the Board or the
Committee and set forth in the terms of the applicable Offering,  no employee of
the Company or any  Affiliate  shall be eligible to be granted  rights under the
Plan,  unless, on the Offering Date, such employee's  customary  employment with
the Company or such  Affiliate is at least 20 hours per week,  and at least five
(5) months per calendar year.

         (b) The Board or the  Committee  may  provide  that,  each  person who,
during the course of an  Offering  first  becomes an  eligible  employee  of the
Company  or  designated  Affiliate  will,  on a date or dates  specified  in the
Offering,  which coincides with the day on which such person becomes an eligible
employee  occurs  thereafter,  receive a right under that Offering,  which right
shall thereafter be deemed to be a part of that Offering.  Such right shall have
the same  characteristics  as any rights originally granted under that Offering,
as described herein, except that:

                    (i) the date on which  such  right is  granted  shall be the
               "Offering  Date"  of  such  right  for  all  purposes,  including
               determination of the exercise price of such right;

                    (ii) the  Offering  Period for such right shall begin on its
               Offering  Date  and  end  simultaneously  with  the  end of  such
               Offering; and

                    (iii) the Board or the  Committee  may provide  that if such
               person  first  becomes an  eligible  employee  within a specified
               period of time before the end of the Offering, he or she will not
               receive any right under that Offering.

          (c) No employee  shall be eligible  for the grant of any rights  under
the Plan if,  immediately after any such rights are granted,  such employee owns
stock possessing five percent (5%) or more of the total combined voting power or
value of all classes of stock of the Company or of an Affiliate. For purposes of
this  subparagraph  5(c), the rules of Section 424(d) of the Code shall apply in
determining the stock  ownership of any employee,  and stock which such employee
may purchase under all outstanding  rights and options shall be treated as stock
owned by such employee.



<PAGE>

         (d) An eligible  employee may be granted  rights under the Plan only if
such  rights,  together  with any other rights  granted  under  "employee  stock
purchase  plans" of the  Company and any  Affiliates,  as  specified  by Section
423(b)(8) of the Code, do not permit such employee's rights to purchase stock of
the  Company  or any  Affiliate  to accrue at a rate which  exceeds  twenty-five
thousand dollars ($25,000) of the fair market value of such stock (determined at
the time such rights are  granted) for each  calendar  year in which such rights
are outstanding at any time.

         (e)  Officers  of the  Company and any  designated  Affiliate  shall be
eligible to participate in Offerings under the Plan, provided, however, that the
Board  may  provide  in an  Offering  that  certain  employees  who  are  highly
compensated  employees  within the meaning of Section  423(b)(4)(D)  of the Code
shall not be eligible to participate.

6.       RIGHTS; PURCHASE PRICE.

         (a) On each  Offering  Date,  each  eligible  employee,  pursuant to an
Offering  made under the Plan,  shall be granted the right to purchase up to the
number of shares of Common  Stock of the Company  purchasable  with a percentage
designated by the Board or the Committee not exceeding  fifteen percent (15%) of
such  employee's  Earnings (as defined in Section  7(a)) during the period which
begins on the  Offering  Date (or such later date as the Board or the  Committee
determines  for a  particular  Offering)  and  ends on the  date  stated  in the
Offering,  which date shall be no more than 12 months  after the  Offering  Date
(the "Offering Period").  In connection with each Offering made under this Plan,
the Board or the Committee shall specify a maximum number of shares which may be
purchased by any employee as well as a maximum  aggregate number of shares which
may be  purchased  by all  eligible  employees  pursuant  to such  Offering.  In
addition,  in  connection  with  each  Offering  which  contains  more  than one
"Purchase  Date" (as defined in the  Offering),  the Board or the  Committee may
specify a maximum  aggregate  number of  shares  which may be  purchased  by all
eligible  employees  on any  given  Purchase  Date  under the  Offering.  If the
aggregate  purchase of shares upon exercise of rights granted under the Offering
would exceed any such maximum aggregate number, the Board or the Committee shall
make a pro rata allocation of the shares available in as nearly a uniform manner
as shall be practicable and as it shall deem to be equitable.

         (b) The purchase  price of stock  acquired  pursuant to rights  granted
under the Plan shall be not less than the lesser of:

                    (i) an amount equal to eighty-five percent (85%) of the fair
               market value of the stock on the Offering Date; or

                    (ii) an amount  equal to  eighty-five  percent  (85%) of the
               fair market value of the stock on the Purchase Date.

7.       PARTICIPATION; WITHDRAWAL; TERMINATION.

         (a) An eligible  employee  may become a  participant  in an Offering by
delivering a participation agreement to the Company within the time specified in
the Offering,  in such form as the Company  provides.  Each such agreement shall
authorize payroll  deductions of up to the maximum  percentage  specified by the
Board or the Committee of such employee's  "Earnings" (as  hereinafter  defined)
during the Offering Period. "Earnings" is defined as the total compensation paid
to an employee,  including all salary,  wages  (including  amounts elected to be
deferred by the employee, that would otherwise have been paid, under any cash or
deferred  arrangement  established by the Company),  overtime pay,  commissions,
bonuses,  and other  remuneration  paid directly to the employee,  but excluding
profit sharing, the cost of employee benefits paid for the Company, education or
tuition reimbursements, imputed income arising under any Company group insurance
or  benefit   program,   traveling   expenses,   business  and  moving   expense
reimbursements,  income received in connection with stock options, contributions
made by the Company  under any  employee  benefit  plan,  and  similar  items of
compensation. The payroll deductions made for each participant shall be credited
to an account for such  participant  under the Plan and shall be deposited  with
the general funds of the Company.  A participant  may reduce,  increase or begin
such payroll  deductions  after the  beginning  of any  Offering  Period only as
provided for in the Offering.  A participant may make  additional  payments into
his or her account only if specifically provided for in the Offering and only if
the  participant  has not had the maximum  amount  withheld  during the Offering
Period. 

          (b) At any time during an Offering Period, a participant may terminate
his or her payroll  deductions under the Plan and may withdraw from the Offering
by  delivering to the Company a notice of withdrawal in such form as the Company
provides.  Such  withdrawal  may be  elected at any time prior to the end of the
Offering  Period  except  as  provided  by the  Board  or the  Committee  in the
Offering.  Upon such withdrawal from the Offering by a participant,  the Company
shall distribute to such


<PAGE>


participant all of his or her  accumulated  payroll  deductions  (reduced to the
extent,  if any,  such  deductions  have  been  used to  acquire  stock  for the
participant)  under  the  Offering,  without  interest,  and such  participant's
interest in that Offering shall be  automatically  terminated.  A  participant's
withdrawal  from  an  Offering  will  have no  effect  upon  such  participant's
eligibility  to  participate  in any  other  Offerings  under  the Plan but such
participant will be required to deliver a new  participation  agreement in order
to participate in subsequent Offerings under the Plan.

         (c)  Rights  granted  pursuant  to any  Offering  under the Plan  shall
terminate immediately upon cessation of any participating  employee's employment
with the Company and any designated  Affiliate,  for any reason, and the Company
shall  distribute  to such  terminated  employee  all of his or her  accumulated
payroll  deductions  (reduced to the extent,  if any, such  deductions have been
used to acquire stock for the terminated employee),  under the Offering, without
interest.

         (d) Rights granted under the Plan shall not be transferable,  and shall
be exercisable only by the person to whom such rights are granted.

8.       EXERCISE.

         (a) On each  Purchase  Date,  each  participant's  accumulated  payroll
deductions  and  other  additional  payments  specifically  provided  for in the
Offering  (without any increase for interest) will be applied to the purchase of
whole  shares  of stock of the  Company,  up to the  maximum  number  of  shares
permitted pursuant to the terms of the Plan and the applicable Offering,  at the
purchase price specified in the Offering.  No fractional  shares shall be issued
upon the  exercise of rights  granted  under the Plan.  The  amount,  if any, of
accumulated payroll deductions remaining in each participant's account after the
purchase of shares which is less than the amount  required to purchase one share
of stock on the final  Purchase  Date of an Offering  shall be held in each such
participant's  account for the purchase of shares under the next Offering  under
the Plan in which the participant enrolled, unless (i) the participant withdraws
from such next  Offering  under the Plan in which the  participant  is enrolled,
(ii) such  participant  withdraws  from  such  next  Offering,  as  provided  in
subparagraph  7(b), or (iii) the participant is no longer eligible to be granted
rights  under the Plan,  as provided in  paragraph  5, in which case such amount
shall be distributed to the participant after said final Purchase Date,  without
interest. The amount, if any, of accumulated payroll deductions remaining in any
participant's  account after the purchase of shares which is equal to the amount
required  to purchase a whole  share of stock on the final  Purchase  Date of an
Offering  shall be distributed  in full to the  participant  after such Purchase
Date, without interest.

         (b) No rights  granted  under the Plan may be  exercised  to any extent
unless the Plan (including rights granted thereunder) is covered by an effective
registration  statement  pursuant to the Securities Act of 1933, as amended (the
"Securities  Act"). If on a Purchase Date of any Offering  hereunder the Plan is
not so  registered,  no rights granted under such Offering shall be exercised on
said  Purchase  Date and the  Purchase  Date shall be delayed  until the Plan is
subject to such an effective  registration  statement,  except that the Purchase
Date shall not be delayed more than two (2) months and the  Purchase  Date shall
in no event be more than 12 months from the  Offering  Date.  If on the Purchase
Date of any Offering  hereunder,  as delayed to the maximum extent  permissible,
the Plan is not  registered,  no rights  granted  under such  Offering  shall be
exercised  and all payroll  deductions  accumulated  during the Offering  Period
(reduced to the extent, if any, such deductions have been used to acquire stock)
shall be distributed to the participants, without interest.

9.       COVENANTS OF THE COMPANY.

         (a) During the terms of the rights  granted under the Plan, the Company
shall  keep  available  at all times the number of shares of stock  required  to
satisfy such rights.

         (b) The Company shall seek to obtain from each regulatory commission or
agency having  jurisdiction  over the Plan such  authority as may be required to
issue and sell  shares of stock upon  exercise of the rights  granted  under the
Plan.  If, after  reasonable  efforts,  the Company is unable to obtain from any
such regulatory commission or agency the authority which counsel for the Company
deems  necessary for the lawful  issuance and sale of stock under the Plan,  the
Company shall be relieved from any liability for failure to issue and sell stock
upon exercise of such rights unless and until such authority is obtained.

10.      USE OF PROCEEDS FROM STOCK.

         Proceeds  from the sale of stock  pursuant to rights  granted under the
Plan shall constitute general funds of the Company.

<PAGE>


11.      RIGHTS AS A STOCKHOLDER.

         A  participant  shall not be deemed to be the holder of, or to have any
of the rights of a holder with respect to, any shares  subject to rights granted
under the Plan unless and until the  participant's  shareholdings  acquired upon
exercise of rights hereunder are recorded in the books of the Company.

12.      ADJUSTMENTS UPON CHANGES IN STOCK.

         (a) If any change is made in the stock  subject to the Plan, or subject
to  any  rights   granted  under  the  Plan  (through   merger,   consolidation,
reorganization,  recapitalization,  stock  dividend,  dividend in property other
than cash, stock split, liquidating dividend, combination of shares, exchange of
shares,  change in corporate  structure or otherwise),  the Plan and outstanding
rights will be  appropriately  adjusted in the class(es)  and maximum  number of
shares  subject to the Plan and the class(es) and number of shares and price per
share of stock subject to outstanding rights.

         (b) In the event of: (1) a dissolution  or  liquidation of the Company;
(2) a  merger  or  consolidation  in  which  the  Company  is not the  surviving
corporation;  (3) a  reverse  merger  in  which  the  Company  is the  surviving
corporation but the shares of the Company's Common Stock outstanding immediately
preceding the merger are converted by virtue of the merger into other  property,
whether in the form of securities,  cash or otherwise;  or (4) any other capital
reorganization  in which  more than  fifty  percent  (50%) of the  shares of the
Company entitled to vote are exchanged,  then, as determined by the Board in its
sole discretion (i) any surviving  corporation may assume  outstanding rights or
substitute  similar  rights  for  those  under the Plan,  (ii) such  rights  may
continue in full force and effect, or (iii)  participants'  accumulated  payroll
deductions  may be  used to  purchase  Common  Stock  immediately  prior  to the
transaction  described  above and the  participants'  rights  under the  ongoing
Offering terminated.

13.      AMENDMENT OF THE PLAN.

         (a) The Board at any time,  and from time to time,  may amend the Plan.
However, except as provided in paragraph 12 relating to adjustments upon changes
in stock, no amendment shall be effective unless approved by the stockholders of
the Company  within 12 months  before or after the  adoption  of the  amendment,
where the amendment will:

                    (i) increase the number of shares  reserved for rights under
               the Plan;

                    (ii)   modify  the   provisions   as  to   eligibility   for
               participation  in the  Plan  (to  the  extent  such  modification
               requires  stockholder  approval  in order  for the Plan to obtain
               employee stock  purchase plan treatment  under Section 423 of the
               Code or to comply with the requirements of Rule 16b-3 promulgated
               under the  Securities  Exchange  Act of 1934,  as amended  ("Rule
               16b-3")); or

                    (iii)  modify  the  Plan  in any  way if  such  modification
               requires  stockholder  approval  in order  for the Plan to obtain
               employee stock  purchase plan treatment  under Section 423 of the
               Code or to comply with the requirements of Rule 16b-3.

It is  expressly  contemplated  that the Board may amend the Plan in any respect
the Board deems  necessary or advisable to provide  eligible  employees with the
maximum benefits provided or to be provided under the provisions of the Code and
the regulations promulgated thereunder relating to employee stock purchase plans
and/or  to bring  the  Plan  and/or  rights  granted  under  it into  compliance
therewith.

         (b) Rights and obligations under any rights granted before amendment of
the Plan shall not be altered or impaired by any  amendment of the Plan,  except
with the  consent of the person to whom such  rights  were  granted or except as
necessary to comply with any laws or governmental regulation.

14.      DESIGNATION OF BENEFICIARY.

         (a) A participant  may file a written  designation of a beneficiary who
is to receive any shares and cash, if any, from the participant's  account under
the Plan in the event of such participant's death subsequent to a purchase under
the Offering but prior to delivery to him of such shares and cash.  In addition,
a participant may file a written  designation of a beneficiary who is to receive
any cash  from the  participant's  account  under  the Plan in the event of such
participant's death prior to the end of an Offering.

<PAGE>


         (b) Such  designation of beneficiary  may be changed by the participant
at any time by written notice. In the event of the death of a participant and in
the absence of a beneficiary  validly designated under the Plan who is living at
the time of such  participant's  death,  the Company  shall  deliver such shares
and/or cash to the executor or  administrator  of the estate of the participant,
or if no such executor or administrator  has been appointed (to the knowledge of
the Company),  the Company,  in its  discretion,  may deliver such shares and/or
cash  to the  spouse  or to any  one or  more  dependents  or  relatives  of the
participant,  or if no spouse,  dependent  or relative is known to the  Company,
then to such other person as the Company may designate.

15.      TERMINATION OR SUSPENSION OF THE PLAN.

         (a) The Board may  suspend or  terminate  the Plan at any time.  Unless
sooner terminated,  the Plan shall terminate on December 31, 2006. No rights may
be granted under the Plan while the Plan is suspended or after it is terminated.

         (b) Rights and  obligations  under any rights granted while the Plan is
in effect shall not be altered or impaired by suspension or  termination  of the
Plan,  except with the consent of the person to whom such rights were granted or
except as necessary to comply with any laws or governmental regulation.

16.      EFFECTIVE DATE OF PLAN.

         The Plan shall become  effective  as  determined  by the Board,  but no
rights  granted under the Plan shall be exercised  unless and until the Plan has
been approved by the stockholders of the Company.



<PAGE>



                          ARONEX PHARMACEUTICALS, INC.
                        1997 EMPLOYEE STOCK PURCHASE PLAN
                   FORM OF ENROLLMENT/CHANGE/WITHDRAWAL NOTICE
              (Please type or use ballpoint pen and print clearly)


I.       ENROLLMENT AND PAYROLL DEDUCTION PERCENTAGE

II.      CHANGE IN PAYROLL DEDUCTION PERCENTAGE

III.     ELECTION TO WITHDRAW


EMPLOYEE DATA:

Shares  purchased  under  Aronex  Pharmaceuticals,  Inc.  (the  "Company")  1997
Employee Stock Purchase Plan (the "Plan") will be registered as shown below.

Name:
     ------------------------------------------------------------------------- 
                           Last             First             M.I.

Address:
     -------------------------------------------------------------------------
         Street               City            State or Country        Zip

         Social Security No. ____________________  Date of Hire _______________

              SECTION I - ENROLLMENT & PAYROLL DEDUCTION PERCENTAGE

|_| I wish to  participate  in the  Plan and  offerings  thereunder  and  hereby
authorize payroll deductions as indicated below.

         Percentage of base pay to be deducted:

               |_|      |_|      |_|     |_|      |_|      |_|      |_|
                1%       2%       3%      4%       5%       6%       7%

               |_|      |_|      |_|     |_|      |_|      |_|      |_|    |_|
                8%       9%      10%     11%      12%      13%      14%    15%

         I understand  that deductions will begin as soon as permitted under the
Plan and the  applicable  Offering  and that my  participation  in the Plan will
continue as set forth in any applicable  Offering under the Plan until such time
as I elect to withdraw from the Plan.

         In the  event of my  death,  I hereby  designate  the  following  as my
beneficiary(ies) to receive all payments and shares due me under the Plan:



<PAGE>


Name:  (Please Print)
                     ---------------------------------------------------------
                           rst)              (Middle)               (Last)


       Relationship:
                    ---------------------------------------------------------

                    --------------------------------------------------------
                                                                   (Address)

               SECTION II - CHANGE IN PAYROLL DEDUCTION PERCENTAGE

|_|  I wish to change my current payroll deduction percentage to the following
     indicated percentage:

         |_|      |_|      |_|     |_|      |_|      |_|      |_|      |_|
          0%       1%       2%      3%       4%       5%       6%       7%

         |_|      |_|      |_|     |_|      |_|      |_|      |_|      |_|
          8%       9%      10%     11%      12%      13%      14%      15%

                  SECTION III - ELECTION TO WITHDRAW FROM PLAN

|_|  I wish to stop my payroll deductions and to withdraw from the Plan 
     effective immediately.

         I  understand  that all of my  accumulated  deductions  (reduced to the
extent such  deductions  have been used to acquire stock) will be distributed to
me without interest.  I understand that I must complete a new enrollment form to
rejoin the Plan and that I may only rejoin the Plan at the beginning of the next
Offering.

         I hereby  authorize  the  Company  to enroll  me in the  Plan,  to make
regular deductions in the amount indicated above, and to purchase shares for me.
If I have  elected  to  withdraw  from the Plan,  I  authorize  the  Company  to
distribute  my  accumulated  deductions  to me. Any  authorization  for  payroll
deductions  will continue until  cancelled or changed by me on a form prescribed
by the Company.  Deductions  will cease upon the termination of my employment or
termination  of the Plan or if I have elected to withdraw from the Plan. I agree
to be bound by the  terms  and  provisions  of the  Plan,  as  described  in the
official text of the Plan, and any applicable Offering document.


- ---------------------------------------         -------------------------------
Signature of Employee                           Date



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