ARONEX PHARMACEUTICALS INC
DEF 14A, 1996-06-06
PHARMACEUTICAL PREPARATIONS
Previous: MAF BANCORP INC, 10-C, 1996-06-06
Next: FOUNDERS ASSET MANAGEMENT INC, SC 13G, 1996-06-06



                            SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
                                (Amendment No. )

Filed by the Registrant [X]

Filed by a Party other than the Registrant [    ]

Check the appropriate box:

[  ]   Preliminary Proxy Statement

[  ]   Confidential, for Use of the Commission Only (as permitted by Rule
       14a-6(e)(2))

[ X]   Definitive Proxy Statement

[  ]   Definitive Additional Materials

[  ]   Soliciting Material Pursuant to ss. 240.14a-11(c) or  ss. 240.14a-12


                          ARONEX PHARMACEUTICALS, INC.
              -------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

    ----------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[X]   $125 per Exchange Act Rules 0-11(c)(1)(ii), 14a-6(i)(1), 14a-6(i)(2)
      or Item 22(a)(2) of Schedule 14A.

[ ]   $500 per  each  party  to the  controversy  pursuant  to  Exchange  Act
      Rule 14a-6(i)(3).

[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

       1)     Title of each class of securities to which transaction applies:

              --------------------------------------------------------------

       2)     Aggregate number of securities to which transaction applies:

              --------------------------------------------------------------

       3)     Per unit price or other underlying  value of transaction  computed
              pursuant to Exchange  Act Rule 0-11 (Set forth the amount on which
              the filing fee is calculated and state how it was determined):

              --------------------------------------------------------------

       4)     Proposed maximum aggregate value of transaction:

              --------------------------------------------------------------

       5)     Total fee paid:

              --------------------------------------------------------------

[ ] Fee paid previously with preliminary materials.

[ ] Check box if any part of the fee is offset as provided  by  Exchange  Act
    Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was
    paid  previously.  Identify the previous filing by  registration  statement
    number, or the Form or Schedule and the date of its filing.

       1)     Amount Previously Paid:

              --------------------------------------------------------------

       2)     Form, Schedule or Registration Statement No.:

              --------------------------------------------------------------

       3)     Filing Party:

              --------------------------------------------------------------

       4)     Date Filed:


              --------------------------------------------------------------

<PAGE>  2




                                        [ARONEX PHARMACEUTICALS, INC. LOGO]





                                            3400 Research Forest Drive
                                            The Woodlands, Texas 77381



                                                   June 6, 1996




TO OUR STOCKHOLDERS:

       You  are  cordially   invited  to  attend  the  1996  Annual  Meeting  of
Stockholders  of Aronex  Pharmaceuticals,  Inc. to be held on  Tuesday,  July 9,
1996, at 1:00 p.m., local time, in the Crockett Room of The Woodlands  Executive
Conference Center, 2301 North Millbend Drive, The Woodlands,  Texas. A Notice of
the Annual  Meeting,  Proxy  Statement  and form of proxy are enclosed with this
letter.

       We  encourage  you to read the  Notice of the  Annual  Meeting  and Proxy
Statement  so that you may be  informed  about the  business  to come before the
meeting.  Your participation in the Company's business is important,  regardless
of the number of shares  that you hold.  To ensure  your  representation  at the
meeting,  please  promptly  sign and return the  accompanying  proxy card in the
postage-paid envelope.

       Separately,  I am pleased to inform you that the Company has successfully
completed the public offering of 6,900,000 shares of Common Stock, including the
exercise of the underwriters'  over-allotment  option.  The Company expects that
the net proceeds of approximately $32.1 million from the offering, together with
its  existing  capital  resources,  will  be  sufficient  to  fund  its  capital
requirements  through the end of 1998.  In  connection  with the  offering,  the
Company agreed to seek  stockholder  approval of a one-for-two  reverse split of
the Company's  Common Stock for reasons that included the Company's  belief that
the  reverse  stock  split  would  make its  Common  Stock  more  attractive  to
institutional  investors,  and the advice of the underwriters that they believed
the  marketability  of the Common Stock in the offering would be enhanced by the
reverse split. The reverse split was approved by the stockholders of the Company
at the Special Meeting of Stockholders held on May 24, 1996. The Company intends
to effect the reverse split on July 1, 1996,  following which time  stockholders
will  be  sent  a  transmittal  form  to  be  used  in  forwarding  certificates
representing  pre-split Common Stock for surrender and exchange for certificates
representing  post-split  Common  Stock.  Stockholders  should  not  send  their
certificates until they receive a transmittal form.

        We look forward to seeing you on July 9th.


                                                        Sincerely,



                                                        James M. Chubb
                                                        President


<PAGE>  3





                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                             TO BE HELD JULY 9, 1996

To the Stockholders of Aronex Pharmaceuticals, Inc.:

         The Annual  Meeting of  Stockholders  (the "Annual  Meeting") of Aronex
Pharmaceuticals, Inc. will be held on Tuesday, July 9, 1996, at 1:00 p.m., local
time, in the Crockett Room of The Woodlands  Executive  Conference Center,  2301
North Millbend Drive, The Woodlands, Texas, for the following purposes:

                    1. To elect three Class III  directors of the Company,  each
               to serve until the Company's 1999 Annual Meeting of  Stockholders
               or until their  respective  successors have been duly elected and
               qualified;

                    2. To vote upon a proposal  to amend and  restate the Aronex
               Pharmaceuticals,  Inc. 1993 Non- Employee  Director  Stock Option
               Plan;

                    3. To ratify and approve the  appointment of Arthur Andersen
               LLP as the  Company's  independent  public  accountants  for  its
               fiscal year ending December 31, 1996; and

                    4. To act upon such  other  business  as may  properly  come
               before the meeting or any adjournments thereof.

         Only  stockholders  of record at the close of  business on May 15, 1996
will be entitled to notice of and to vote at the Annual Meeting.

         It is important  that your shares be  represented at the Annual Meeting
regardless of whether you plan to attend. THEREFORE,  PLEASE MARK, SIGN AND DATE
THE  ENCLOSED  PROXY AND  RETURN IT IN THE  ACCOMPANYING  POSTPAID  ENVELOPE  AS
PROMPTLY AS POSSIBLE.  If you are present at the Annual Meeting,  and wish to do
so, you may revoke the proxy and vote in person.

                                            By Order of the Board of Directors,


                                            Terance A. Murnane
                                            Secretary


The Woodlands, Texas
June 6, 1996


<PAGE>  4




                          ARONEX PHARMACEUTICALS, INC.
                           3400 RESEARCH FOREST DRIVE
                           THE WOODLANDS, TEXAS 77381


                                 PROXY STATEMENT
                                       FOR
                         ANNUAL MEETING OF STOCKHOLDERS


                             TO BE HELD JULY 9, 1996



                    SOLICITATION AND REVOCABILITY OF PROXIES

         The accompanying Proxy is solicited by the Board of Directors of Aronex
Pharmaceuticals,  Inc.  (the  "Company"),  to be voted at the Annual  Meeting of
Stockholders  of the  Company to be held on Tuesday,  July 9, 1996 (the  "Annual
Meeting"),  at 1:00 p.m.,  local time,  in the  Crockett  Room of The  Woodlands
Executive  Conference Center,  2301 North Millbend Drive, The Woodlands,  Texas,
for the  purposes  set forth in the  accompanying  Notice of Annual  Meeting  of
Stockholders,   and  at  any  adjournment(s)  of  the  Annual  Meeting.  If  the
accompanying  proxy is properly executed and returned,  the shares it represents
will be voted at the Annual  Meeting in  accordance  with the  directions  noted
thereon  or,  if no  direction  is  indicated,  it will be voted in favor of the
proposals  described in this Proxy  Statement.  In addition,  the proxy  confers
discretionary  authority  to the persons  named in the proxy  authorizing  those
persons to vote, in their discretion, on any other matters properly presented at
the Annual  Meeting.  The Board of Directors is not currently  aware of any such
other matters.

         Each stockholder of the Company has the  unconditional  right to revoke
his Proxy at any time  prior to its  exercise,  either  in person at the  Annual
Meeting or by written  notice to the  Company  addressed  to  Secretary,  Aronex
Pharmaceuticals,  Inc., 3400 Research Forest Drive, The Woodlands,  Texas 77381.
No  revocation by written  notice will be effective  unless such notice has been
received by the Secretary of the Company prior to the day of the Annual  Meeting
or by the inspector of election at the Annual Meeting.

         The  principal  executive  offices of the  Company  are located at 3400
Research Forest Drive, The Woodlands,  Texas 77381. This Proxy Statement and the
accompanying Notice of Annual Meeting of Stockholders and Proxy are being mailed
to the Company's stockholders on or about June 6, 1996.

         In  addition  to the  solicitation  of  proxies  by use of  this  Proxy
Statement,  directors,  officers  and  employees  of the Company may solicit the
return of proxies by mail, personal interview,  telephone or telegraph. Officers
and employees of the Company will not receive additional  compensation for their
solicitation efforts, but they will be reimbursed for any out-of-pocket expenses
incurred.  Brokerage houses and other custodians,  nominees and fiduciaries will
be requested, in connection with the stock registered in their names, to forward
solicitation materials to the beneficial owners of such stock.

         All costs of preparing,  printing, assembling and mailing the Notice of
Annual Meeting of Stockholders, this Proxy Statement, the enclosed form of Proxy
and any  additional  materials,  as well as the cost of forwarding  solicitation
materials to the beneficial owners of stock and all other costs of solicitation,
will be borne by the Company.


                                       -1-

<PAGE>  5



                             PURPOSES OF THE MEETING

         At the Annual  Meeting,  the  Company's  stockholders  will be asked to
consider and act upon the following matters:

                    1. The election of three Class III directors of the Company,
               each  to  serve  until  the  Company's  1999  Annual  Meeting  of
               Stockholders or until their respective  successors have been duly
               elected and qualified;

                    2.  A   proposal   to   amend   and   restate   the   Aronex
               Pharmaceuticals,  Inc. 1993  Non-Employee  Director  Stock Option
               Plan;

                    3. A  proposal  to ratify and  approve  the  appointment  of
               Arthur   Andersen  LLP  as  the  Company's   independent   public
               accountants for its fiscal year ending December 31, 1996; and

                    4. Such  other  business  as may  properly  come  before the
               meeting or any adjournments thereof.


                                QUORUM AND VOTING

         The close of business on May 15, 1996 has been fixed as the record date
(the "Record Date") for the  determination  of stockholders  entitled to vote at
the Annual Meeting and any  adjournment(s)  thereof.  As of the Record Date, the
Company  had issued and  outstanding  21,937,838  shares of Common  Stock and no
shares of the Company's Preferred Stock, par value $.001 per share.

         Each stockholder of record of Common Stock will be entitled to one vote
per share on each matter that is called to vote at the Annual Meeting.

         The presence, either in person or by proxy, of holders of a majority of
the  outstanding  shares of Common Stock is necessary to  constitute a quorum at
the Annual Meeting. Abstentions and broker non-votes are counted for purposes of
determining  whether a quorum is present.  A plurality  vote is required for the
election  of  directors.  Accordingly,  if a quorum  is  present  at the  Annual
Meeting,  the three  persons  receiving  the  greatest  number of votes  will be
elected  to serve as  directors.  Withholding  authority  to vote for a director
nominee and broker  non-votes in the  election of directors  will not affect the
outcome of the election of directors.  The affirmative vote of the holders of at
least a majority of the  outstanding  shares of Common Stock is required for the
approval of the proposal to amend and restate the Aronex  Pharmaceuticals,  Inc.
1993  Non-Employee  Director  Stock Option Plan.  Since  abstentions  and broker
non-votes are not affirmative  votes for such proposal,  they will have the same
effect as votes against such proposal.  All other matters to be voted on will be
decided  by the vote of the  holders  of a  majority  of the  shares  present or
represented  at the Annual  Meeting and entitled to vote on such matter.  On any
such matter,  an  abstention  will have the same effect as a negative  vote but,
because  shares  held by  brokers  will not be  considered  entitled  to vote on
matters as to which the brokers withhold authority,  a broker non-vote will have
no effect on such vote.

         All Proxies that are properly  completed,  signed and returned prior to
the  Annual  Meeting  will be voted.  Any Proxy  given by a  stockholder  may be
revoked at any time before it is  exercised by the  stockholder  (i) filing with
the  Secretary  of the Company an  instrument  revoking it, (ii)  executing  and
returning a Proxy bearing a later date or (iii) attending the Annual Meeting and
expressing a desire to vote his shares of Common Stock in person.  Votes will be
counted by American Stock Transfer & Trust Company, the Company's transfer agent
and registrar.

                                       -2-

<PAGE>  6



                               PROPOSAL NUMBER 1:
                              ELECTION OF DIRECTORS

         The  Company's  Restated  Certificate  of  Incorporation,  as  amended,
provides that the Board of Directors of the Company is divided or  "classified,"
with respect to the time for which they  individually  hold  office,  into three
classes  ("Classes I, II and III"),  with each class consisting of, as nearly as
possible,  one third of the entire Board.  The  Company's  Board of Directors is
currently fixed at eight members.  Each director is elected to hold office for a
term ending on the date of the third annual meeting following the annual meeting
at which such  director  was elected.  The current term for Class III  Directors
will expire at the Annual  Meeting.  The  current  term for Class I and Class II
Directors  will  expire at the 1998 and 1997 Annual  Meetings  of  Stockholders,
respectively.

         The  Board of  Directors  has  nominated  and urges you to vote for the
election of the three  nominees  identified  below,  who have been  nominated to
serve as Class III directors for a three-year term or until their successors are
duly elected and qualified. Each of the nominees listed below is a member of the
Company's present Board of Directors. Proxies solicited hereby will be voted for
all three nominees unless stockholders specify otherwise in their Proxies.

         If, at the time of or prior to the Annual Meeting,  any of the nominees
should be unable or decline to serve, the  discretionary  authority  provided in
the Proxy may be used to vote for a substitute or substitutes  designated by the
Board of  Directors.  The Board of  Directors  has no reason to believe that any
substitute nominee or nominees will be required.

Nominees for Director

         The three  nominees  for  election as Class III  directors  and certain
additional information with respect to each of them, are as follows:


<TABLE>
<CAPTION>
                                                                                            Year First
         Name                      Age             Position with the Company            Became a Director
         ----                      ---             -------------------------            -----------------
<S>                                <C>        <C>                                             <C>    

James M. Chubb, Ph.D.              48         President and Director (Class III)              1995
George B. Mackaness, M.D.          73                Director (Class III)                     1991
Gregory F. Zaic                    48                Director (Class III)                     1995
</TABLE>

     James M. Chubb,  Ph.D. has served as President and as a member of the Board
of Directors of the Company since the consummation of the Company's  acquisition
of  Triplex   Pharmaceutical   Corporation   ("Triplex")  and  Oncologix,   Inc.
("Oncologix") in a three-way merger (the "Mergers") in September 1995. Dr. Chubb
joined Triplex as President and Chief  Executive  Officer in 1990.  From 1978 to
1990, he held a number of positions  with  increasing  responsibility  at Glaxo,
Inc.,  a  major   pharmaceutical   company.  At  Glaxo,  Dr.  Chubb  headed  the
anti-infective,  respiratory, and dermatological development groups and directed
the cardiovascular and gastrointestinal development groups. He held the position
of adjunct  professor at the  University of North  Carolina  College of Pharmacy
from 1986 to 1990. Dr. Chubb is a director of RGene Therapeutics, Inc.

     George B. Mackaness,  M.D. has served as a member of the Board of Directors
since May 1991. Dr.  Mackaness was President of the Squibb Institute for Medical
Research from January 1976 until his retirement in December 1987. He served as a
member of the Board of Directors of Squibb  Corporation from December 1984 until
December 1987.

     Gregory  F. Zaic has  served as a member  of the Board of  Directors  since
1995.  Mr.  Zaic has been an  investor  primarily  focused on  medical  and life
science investment  opportunities  since 1983. He currently is a General Partner
with Prince  Ventures  and has served as acting  president  and director of many
private and public  companies,  including  GenVec,  Inc. and  Strategic  Medical
Information,  Inc.  Before his  investment  career,  Mr.  Zaic served in several
financial,

                                       -3-

<PAGE>  7



technical,  and operational  capacities,  including heading the Special Products
Division  of  Baxter,   a  manufacturer   of  custom  medical  devices  for  the
cardiopulmonary and intravenous solution administration markets.

         The Board of  Directors  recommends  that  stockholders  vote "FOR" the
election of each of the above-named nominees.

Current and Continuing Directors

<TABLE>
<CAPTION>

                  Name              Age                       Position
<S>                                  <C>   <C>   
Martin P. Sutter.................... 41    Chairman of the Board of Directors (Class I)
James M. Chubb, Ph.D................ 48    President and Director (Class III)
Gabriel Lopez-Berestein, M.D.(1).... 47    Director (Class II) and Chief Scientific Advisor
Ronald J. Brenner, Ph.D.(2)......... 62    Director (Class I)
John F. Chappell(3)................. 59    Director (Class II)
Geoffrey F. Cox, Ph.D.(1)........... 52    Director (Class II)
George B. Mackaness, M.D.(2)........ 73    Director (Class III)
Gregory F. Zaic(1).................. 48    Director (Class III)
<FN>
- - ---------------------------
(1)  Member of the Audit Committee of the Board of Directors
(2)  Member of the Compensation Committee of the Board of Directors
(3)  Mr. Chappell has notified the Company that he intends to resign from the 
     Board of Directors effective at the Annual Meeting
</FN>
</TABLE>
     Information  regarding the business  experience of Drs. Chubb and Mackaness
and Mr. Zaic is set forth above under the heading "--Nominees for Director."

     Martin P.  Sutter,  a co-founder  of Aronex,  has served as Chairman of the
Board of Directors of the Company since June 1986.  Since July 1988,  Mr. Sutter
has been the Managing General Partner of The Woodlands Venture Partners, L.P., a
venture  capital firm based in The Woodlands,  Texas and the General  Partner of
The Woodlands Venture Fund, L.P., one of the Company's  principal  stockholders.
In addition, Mr. Sutter has been the General Partner of Woodlands/Essex  Venture
Partners,  L.P. since  September 1994. From January 1985 to July 1988, he served
as  President  of The  Woodlands  Venture  Capital  Company.  Mr.  Sutter is the
chairman  of  Zonagen,  Inc.  and RGene  Therapeutics,  Inc.  and a director  of
LifeCell Corporation, all biotechnology companies based in The Woodlands, Texas.

     Gabriel  Lopez-Berestein,  M.D.,  a co-founder  of Aronex,  has served as a
member of the Board of Directors  and the  Company's  Chief  Scientific  Advisor
since January 1988.  Dr.  Lopez-Berestein  is Professor of Medicine and Chief of
the  Immunobiology  and Drug  Carriers  Section at The  University of Texas M.D.
Anderson Cancer Center ("MD Anderson"),  with which he has been affiliated since
1979. Dr. Lopez-Berestein is the author of over 125 publications in the areas of
macrophage research and drug carrier technology. Dr. Lopez-Berestein is also the
recipient  of a number of grants and awards,  including  a Scholar  Award of the
Leukemia Society of America and various NIH awards.

     Ronald J. Brenner,  Ph.D.  has served as a member of the Board of Directors
since  September  1995.  Since 1988,  Dr.  Brenner has been a Vice  President of
Hillman Medical Ventures, Inc., a venture capital firm, and a general partner of
several  Hillman  investment  partnerships.  From 1984 to 1988,  Dr. Brenner was
President and Chief Executive  Officer of Cytogen  Corporation,  a biotechnology
company.  Prior to 1984, he was Vice President,  Corporate External Research, at
Johnson & Johnson, a major  pharmaceutical  company, and also served as Chairman
of McNeil Pharmaceutical, Ortho

                                       -4-

<PAGE>  8


Pharmaceutical Corp. and the Cilag Companies, all subsidiaries of Johnson &
Johnson.  Dr. Brenner is a director of Cytogen Corporation and several privately
held healthcare and environmental companies.

         John F. Chappell has served as a member of the Board of Directors since
September  1995.  Mr.  Chappell  is  President  of  Plexus  Ventures,  Inc.,  an
investment firm which he founded in 1990. Prior to founding Plexus, Mr. Chappell
was employed for 28 years by SmithKline  Corporation and SmithKline Beecham plc.
From 1989 to 1990, he served as Chairman of SmithKline  Beecham  Pharmaceuticals
and as a director of SmithKline  Beecham plc. He was President of SmithKline and
French Laboratories from 1988 to 1989 and was President of SmithKline and French
International  from 1985 to 1988. Mr.  Chappell has notified the Company that he
intends to resign from the Board of Directors effective at the Annual Meeting.

     Geoffrey  F. Cox,  Ph.D.  has served as a member of the Board of  Directors
since January 1994. Dr. Cox joined Genzyme Corporation in 1984 and was appointed
Managing  Director of Genzyme,  Ltd. (U.K.) in 1986 and Senior Vice President of
worldwide  manufacturing  operations in May 1988.  Dr. Cox also has full product
line  responsibility  for the  pharmaceuticals  and fine  chemicals  division of
Genzyme  Corporation.  Prior to joining  Genzyme,  Dr. Cox served as  production
manager of British  Fermentation  Products,  Ltd.,  a division of  Gist-Brocades
N.V.,  from April 1979 to October 1981 and as plant manager from October 1981 to
June 1984.

         The  Company  and  certain  of  its   stockholders  are  parties  to  a
Stockholders  Agreement  which entitles  certain  former  Triplex  stockholders,
certain  persons  who were  stockholders  of the  Company  prior to the  Mergers
("former Argus stockholders"), Genzyme and certain former Oncologix stockholders
to designate  directors of the Company,  and further provides that the president
of the  Company  elected by the Board and in office from time to time shall be a
director.  Of the  Company's  current  directors,  Ronald  J.  Brenner,  John F.
Chappell and Gregory F. Zaic are designees of the former  Triplex  stockholders,
Gabriel Lopez-Berestein,  George B. Mackaness and Martin P. Sutter are designees
of the former Argus stockholders and Geoffrey F. Cox is the designee of Genzyme;
James M. Chubb serves as a member of the Board as the Company's  President.  The
former Oncologix  stockholders  that have the right to designate a director have
not exercised such right at the present time.

DIRECTORS' MEETINGS AND COMPENSATION

         During 1995,  the Board of  Directors  met seven times and took certain
additional  actions by unanimous  written  consent in lieu of  meetings.  During
1995, no director of the Company  attended fewer than 75 percent of the meetings
of the Board of Directors (during the period served),  with the exception of two
former  directors of the Company,  Thomas G. Ricks (who did not attend either of
the two  meetings  held  during the period  served)  and Marc S.  Sandroff  (who
attended one of the two  meetings  held during the period  served),  and John F.
Chappell (who attended two of the five meetings held during the period served).

         The  Company's  directors  do not  receive  any cash  compensation  for
service on the Board of Directors or any committee.  The directors are, however,
reimbursed  for expenses  incurred in connection  with  attending each board and
committee  meeting.  Directors who are not employees of the Company are entitled
to  participate in the Company's  1993  Non-Employee  Director Stock Option Plan
(the  "Director  Plan").  Under  the  Director  Plan  as  currently  in  effect,
non-employee  directors  receive  an option  to  purchase  30,000  shares of the
Company's  Common Stock upon their  initial  election to the Board of Directors,
vesting in equal increments over a five-year period.  The Board of Directors has
adopted amendments to the Director Plan, subject to stockholder  approval at the
Annual Meeting,  (a) that would provide for (i) the grant of options to purchase
25,000 shares of Common Stock to each of the Company's non-employee directors in
office on November 14, 1995 and  thereafter to each  non-employee  director upon
his  initial  election  to the Board and (ii) the  annual  grant of  options  to
purchase  7,500  shares of Common  Stock to each of the  Company's  non-employee
directors,  and (b)  that  would  permit  discretionary  grants  of  options  to
non-employee  directors  who do not serve on the  Compensation  Committee of the
Board of Directors. The Compensation Committee has granted discretionary options
to Mr. Sutter and Dr.  Lopez-Berestein,  subject to stockholder approval of such
amendments,  entitling  them to  purchase  75,000 and  100,000  shares of Common
Stock, respectively. See "Proposal Number 2:

                                       -5-

<PAGE>  9



Approval of the Amendment and  Restatement of the Aronex  Pharmaceuticals,  Inc.
1993 Non-Employee Director Stock Option Plan."

     The Company has a consulting agreement with Gabriel Lopez-Berestein,  M.D.,
whereby the Company is committed to pay consulting fees of $144,000 and $156,000
for 1996 and 1997,  respectively.  The Company paid Dr. Lopez-Berestein $132,000
under the agreement during the year ended December 31, 1995.

BOARD COMMITTEES

         The  Company's  Board  of  Directors  has  an  Audit  Committee  and  a
Compensation  Committee.  The  Board of  Directors  does  not have a  Nominating
Committee.  The  Audit  Committee's  functions  include  making  recommendations
concerning the engagement of independent public accountants,  reviewing with the
independent public accountants the plan and results of the auditing  engagement,
approving  professional  services provided by the independent public accountants
and reviewing the adequacy of the Company's internal  accounting  controls.  The
Compensation Committee makes recommendations concerning compensation,  including
incentive  arrangements,  for the Company's officers. The Compensation Committee
also administers the Company's  Amended and Restated 1989 Stock Option Plan (the
"Employee Option Plan").

         During  1995,  the Audit  Committee  did not meet and the  Compensation
Committee met one time.  During 1995, no director of the Company  attended fewer
than 75 percent of the number of meetings of committees on which he served.

                               PROPOSAL NUMBER 2:
                  APPROVAL OF THE AMENDMENT AND RESTATEMENT OF
                        THE ARONEX PHARMACEUTICALS, INC.
                  1993 NON-EMPLOYEE DIRECTOR STOCK OPTION PLAN

GENERAL

         On  November  14,  1995,   the  Board,   subject  to  approval  by  the
stockholders  of the  Company,  approved  the  amendment  and  restatement  (the
"Amendment")  of the Aronex  Pharmaceuticals,  Inc. 1993  Non-Employee  Director
Stock Option Plan (the  "Director  Plan").  The purpose of the Director Plan, as
originally  approved  by the  Company's  stockholders  in 1993 and after  giving
effect to the Amendment,  is to promote and advance the interests of the Company
by aiding  the  Company  in  attracting  and  retaining  qualified  non-employee
directors  and to further align the  interests of such  directors  with those of
stockholders through stock options. An additional purpose of the Amendment is to
recognize and reward the  contributions of directors who, although not employees
of the  Company,  are  actively  involved in aspects of the  Company's  business
beyond their role as directors. A copy of the Amendment is included as Exhibit A
to this Proxy  Statement and the following  summary is qualified in its entirety
by reference to the complete text of Exhibit A.

         The Amendment provides for the following  modifications to the Director
Plan:

         (i) The number of shares of Common Stock  authorized to be issued under
the Director Plan would be increased to 600,000 shares from 250,000 shares under
the Director Plan as currently in effect.

         (ii)     With respect to formula grants of options:

                  (A) Each non-employee director in office on November 14, 1995,
         the date of the  initial  Board  approval  of the  Amendment,  and each
         non-employee  director  thereafter  elected  to the Board for the first
         time would receive an option to purchase 25,000 shares of Common Stock.
         Under the  Director  Plan as  currently  in effect,  each  non-employee
         director  elected to the Board for the first time receives an option to
         purchase 30,000 shares of Common Stock.

                                       -6-

<PAGE>  10



                  (B) All such  options  would be  vested in full on the date of
         grant.  Under the Director  Plan as  currently in effect,  such options
         vest over a five-year period.

                  (C) All  non-employee  directors  appointed  or elected to the
         Board would be eligible to receive  such  options.  Under the  Director
         Plan as  currently  in  effect,  non-employee  directors  appointed  or
         elected  to  the  Board  in  connection  with  or as a  result  of  the
         completion of a financing, acquisition or other similar transaction are
         not eligible to receive such options.

                  (D) Each  person  serving as a director  on December 31 of any
         year would receive an option to purchase  7,500 shares of Common Stock.
         The  Director  Plan as  currently in effect does not provide for annual
         grants of options.

         (iii) Discretionary grants of options to certain non-employee directors
would be authorized, with the number of shares subject to options, option prices
and other terms to be determined  by the  Compensation  Committee.  The Director
Plan as currently in effect does not authorize discretionary grants of options.

         (iv) The period  during which  options  granted under the Director Plan
may be exercised after a non-employee  director's  resignation would be extended
to 24 months from the 90 days  provided for by the Director Plan as currently in
effect.

Summary of the Director Plan

         The  Director   Plan,   as   originally   approved  by  the   Company's
stockholders,  is a "formula" plan for purposes of Rule 16b-3  promulgated under
the Securities  Exchange Act of 1934, as amended,  pursuant to which options for
shares  of  Common  Stock  are   automatically   granted  to  certain   eligible
non-employee directors of the Company as of specified dates. No person exercises
any  discretion  with respect to persons  eligible to receive  formula grants of
options under the Director Plan or the amount of formula grants thereunder.  The
Amendment   would   authorize   discretionary   grants  of  options  to  certain
non-employee  directors  in  addition  to  the  formula  grants  for  which  all
non-employee directors are eligible.

         Eligibility.  Persons who are non-employee directors of the Company are
eligible to participate  in the Director  Plan. The Company  presently has seven
such directors. Options granted under the Director Plan are transferable only at
the death of a  non-employee  director.  The  Director  Plan sets forth  various
restrictions  upon  the  exercise  of  options  following  the  date on  which a
non-employee  director ceases to be a director.  Discretionary grants of options
to non-employee  directors will be subject to the Company's  determination  that
such grants will not prevent  the  members of the  Compensation  Committee  from
constituting "disinterested persons" within the meaning of Rule 16b-3.

         Shares Subject to Director Plan. The maximum number of shares of Common
Stock in respect of which  options  may be granted  under the  Director  Plan as
currently in effect is 250,000,  which will be increased to 600,000 after giving
effect to the Amendment,  subject in each case to appropriate  adjustment upon a
reorganization,  stock split,  recapitalization or other change in the Company's
capital structure.

          Option Period.  Options  granted to  non-employee  directors under the
Director Plan have a term of ten years from the date of grant.

         Amendment. The Board may amend the Director Plan at any time, including
amendments allowed without shareholder approval as provided under Rule 16b-3, as
that rule may be amended  from time to time,  except  that the Board must obtain
stockholder  approval of any amendment  that would  increase the total number of
shares  reserved  for  issuance  (except for  adjustments  necessary  to reflect
changes  in  capitalization),  materially  modify  eligibility  requirements  or
materially  increase the benefits  accruing to  participants.  The Board may not
amend provisions in the Director Plan regarding eligibility and automatic grants
of options more than once every six months, except to the extent

                                       -7-

<PAGE>  11



necessary to comply with applicable  provisions of the Internal  Revenue Code of
1986, as amended, or regulations promulgated thereunder.

          Non-Qualified   Options.   Options  issued  under  the  Director  Plan
constitute non-qualified stock options.

         Automatic  Grant of Options.  In general,  under the  Director  Plan as
currently in effect,  each  non-employee  director  who is first  elected to the
Board (except for  non-employee  directors  appointed or elected to the Board in
connection  with  or as a  result  of  the  completion  of  certain  financings,
acquisitions or other similar  transactions) is entitled to receive an option to
purchase  30,000  shares of Common Stock on the date on which he first becomes a
non-employee  director.  If the stockholders approve the Amendment at the Annual
Meeting,  each non-employee director in office on November 14, 1995 (the date of
initial approval of the Amendment) and each  non-employee  director who is first
elected  to the  Board  thereafter  (whether  or not  appointed  or  elected  in
connection  with or as a result of the completion of a financing  acquisition or
similar  transaction)  will be entitled to receive an option to purchase  25,000
shares of Common Stock effective on such date. In addition,  if the Amendment is
approved,  each  non-employee  director  in  office on  December  31 of any year
commencing  with December 31, 1996,  provided that such director has served as a
Director for at least six months prior to the date of grant, will be entitled to
receive options  annually on such date to purchase 7,500 shares of Common Stock.
The amounts of all such option grants are subject to appropriate adjustment upon
a reorganization, stock split, recapitalization or other change in the Company's
capital structure.

         Discretionary  Grant  of  Options.  If  the  stockholders  approve  the
Amendment at the Annual Meeting,  non-employee  directors who are not members of
the Compensation  Committee will be eligible to receive  discretionary grants of
options, with the number of shares for which such options may be exercised,  the
exercise  price  of such  options  and the  other  terms of such  options  to be
determined within the discretion of the Compensation Committee.

         Exercisability. Under the Director Plan as currently in effect, options
become  exercisable in 20% increments that vest on each  anniversary of the date
of grant  until the  option is 100%  vested.  If the  stockholders  approve  the
Amendment at the Annual  Meeting,  all options  granted  under the Director Plan
subsequent to the Board's  initial  approval of the Amendment  will be vested in
full at the date of grant, except that the Compensation  Committee may establish
vesting  requirements in its discretion with respect to discretionary  grants of
options. The exercise price for options must be paid in cash.

         Change in Capital  Structure.  Upon a change in the  Company's  capital
structure as a result of a stock split, dividend or recapitalization, the number
of shares  subject to  outstanding  options and reserved under the Director Plan
and the exercise price of outstanding options shall be appropriately adjusted to
reflect  the number and class of shares  that would have been  issuable  if such
shares had been outstanding  immediately  prior to such event.  Upon the merger,
liquidation or sale of  substantially  all of the assets of the Company,  or the
purchase of 50% or more of the Company's  outstanding  Common Stock,  holders of
outstanding  stock options under the Director Plan shall be entitled to receive,
upon exercise of such options, the stock,  securities or other property to which
they would have been entitled had such options been exercised  immediately prior
to such event.

         Option   Exercise   Price.   The  exercise  price  of  options  granted
automatically  under the  Director  Plan is 100% of the fair market value of the
Common  Stock on the date of  grant.  The  exercise  price  of  options  granted
pursuant to the Compensation  Committee's  discretion shall be determined by the
Compensation  Committee,  which may be less than, equal to or more than the fair
market value of the Common Stock on the date of grant.  The "fair market  value"
of a share of Common Stock means,  on any given date,  the closing  price of the
Common  Stock on the Nasdaq  Stock Market or, if the Common Stock is listed on a
national securities exchange, the closing price on the exchange on such date.


                                       -8-

<PAGE>  12



FEDERAL INCOME TAX CONSEQUENCES OF THE DIRECTOR PLAN

         General. A non-employee  director will not recognize any taxable income
at the time an  option is  granted.  Ordinary  income  will be  recognized  by a
non-employee  director at the time of exercise in an amount  equal to the excess
of the fair market value of the shares of Common Stock  received over the option
price for such  shares.  However,  if other  shares of  Common  Stock  have been
purchased  by a  non-employee  director  within six months of the exercise of an
option,  recognition  of the  income  attributable  to such  exercise  may under
certain  circumstances  be  postponed  for a period of up to six months from the
date of such  purchase of such other  shares of Common Stock due to liability to
suit under Section 16(b) of the  Securities and Exchange Act of 1934, as amended
(the " Exchange Act"). If applicable,  one effect of any such postponement would
be to  measure  the  amount of the  non-employee  director's  taxable  income by
reference to the fair market value of such shares at the time such  liability to
suit under Section  16(b) of the Exchange Act no longer  exists  (rather than at
the earlier date of the exercise of the option). The non-employee  director will
generally  recognize a capital gain or loss upon a subsequent sale of the shares
of Common Stock.

         Deductibility.  Upon a  non-employee  director's  exercise of an option
granted  under  the  Director  Plan,  the  Company  may  claim a  deduction  for
compensation  paid at the same time and in the same amount as ordinary income is
recognized by the non-employee director.

OPTION GRANTS UNDER DIRECTOR PLAN

         The  following  table sets  forth the number of shares of Common  Stock
subject to, and the exercise  prices of, options granted under the Director Plan
subject to stockholder approval of the Amendment at the Annual Meeting.
<TABLE>
<CAPTION>

                                                 NEW PLAN BENEFITS

                                                              NUMBER OF            EXERCISE PRICE
                         NAME                            OPTIONS GRANTED(1)          PER SHARE
                         ----                            ------------------          ---------
<S>                                                          <C>                       <C>   

Martin P. Sutter.......................................       100,000(2)               $2.75
Gabriel Lopez-Berestein, M.D...........................       125,000(3)               $2.75
Ronald J. Brenner, Ph.D................................        25,000                  $2.75
John F. Chappell.......................................        25,000                  $2.75
Geoffrey F. Cox, Ph.D..................................        25,000                  $2.75
George B. Mackaness, M.D...............................        25,000                  $2.75
Gregory F. Zaic........................................        25,000                  $2.75
Non-employee directors as a group (7 persons)..........       350,000                  $2.75
<FN>
- - ---------------------------

(1)  Except as otherwise indicated, represents options to purchase 25,000 shares
     of Common Stock granted to all non-employee  directors on November 14, 1995
     at an exercise price of $2.75 per share,  which exercise price was equal to
     the fair market  value of the Common  Stock on the date of grant.  The fair
     market value of the Common Stock on May 31, 1996 was $6.50 per share.
(2)  Includes  options to purchase  30,000 shares of Common Stock granted to Mr.
     Sutter on March 8, 1996,  and options to purchase  45,000  shares of Common
     Stock  granted  to Mr.  Sutter  on April  12,  1996,  in each  case with an
     exercise  price of $2.75 per  share.  Such  shares  vest  over a  four-year
     period.  The fair  market  value of the  Common  Stock on March 8, 1996 was
     $5-15/16 per share and on April 12, 1996 was $4-7/8 per share.
(3)  Includes  options to purchase  30,000 shares of Common Stock granted to Dr.
     Lopez-Berestein  on March 8, 1996, and options to purchase 70,000 shares of
     Common Stock granted to Dr. Lopez-Berestein on April 12, 1996, in each case
     with an  exercise  price  of $2.75  per  share.  Such  shares  vest  over a
     four-year  period.  The fair market  value of the Common  Stock on March 8,
     1996 was $5-15/16 per share and on April 12, 1996 was $4-7/8 per share.
</FN>
</TABLE>

     THE BOARD OF DIRECTORS  RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" APPROVAL OF
THE AMENDMENT AND  RESTATEMENT OF THE DIRECTOR  PLAN,  AND PROXIES  EXECUTED AND
RETURNED WILL BE SO VOTED UNLESS CONTRARY INSTRUCTIONS ARE INDICATED THEREON.

                                       -9-

<PAGE>  13




                               PROPOSAL NUMBER 3:
           RATIFICATION AND APPROVAL OF INDEPENDENT PUBLIC ACCOUNTANTS

     The Board of Directors has appointed the firm of Arthur Andersen LLP as the
Company's  independent public accountants to make an examination of the accounts
of the  Company  for the  fiscal  year  ending  December  31,  1996,  subject to
ratification by the Company's  stockholders.  Representatives of Arthur Andersen
LLP will be present at the Annual Meeting and will have an opportunity to make a
statement,  if they desire to do so. They will also be  available  to respond to
appropriate questions from stockholders attending the Annual Meeting.

     The Board of Directors recommends that stockholders vote "FOR" ratification
and approval of Arthur  Andersen  LLP's  appointment,  and Proxies  executed and
returned will be so voted unless contrary instructions are indicated thereon.

         REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS

     The Compensation  Committee (the  "Committee") of the Board of Directors of
the Company  currently  consists of Ronald J. Brenner,  George B.  Mackaness and
Gregory F. Zaic,  none of whom are officers or  employees  of the  Company.  The
Committee  is  responsible   for  evaluating  the   performance  of  management,
determining the compensation for certain  executive  officers of the Company and
administering the Company's  Employee Option Plan under which grants may be made
to employees of the Company. The Committee has furnished the following report on
executive compensation for 1995:

     Under the  supervision  of the  Committee,  the  Company  has  developed  a
compensation  policy which is  designated  to attract and retain key  executives
responsible  for the success of the Company and motivate  management  to enhance
long-term  stockholder  value.  The annual  compensation  package for  executive
officers   primarily   consists  of  (i)  a  cash  salary  which   reflects  the
responsibilities  relating to the  position  and  individual  performance,  (ii)
variable   performance  awards  payable  in  cash  or  stock  and  tied  to  the
individual's  or the Company's  achievement  of certain goals or milestones  and
(iii) long-term stock based incentive  awards which  strengthen the mutuality of
interests between the executive officers and the Company's stockholders.

     In determining  the level and  composition of  compensation  of each of the
Company's  executive   officers,   the  Committee  takes  into  account  various
qualitative and quantitative indicators of corporate and individual performance.
Although no specific target has been established,  the Committee generally seeks
to set salaries  comparable  to those of peer group  companies.  In setting such
salaries,  the Committee considers its peer group to be certain companies in the
biotechnology  industries  with  market  capitalizations  similar to that of the
Company.  Such  competitive  group does not  necessarily  include the  companies
comprising the Nasdaq Pharmaceutical Index reflected in the performance graph in
this Proxy Statement,  which is the industry categorization the Company has been
placed  in by its  investment  bankers.  Because  the  Company  is  still in the
development stage, the use of certain traditional  performance  standards (e.g.,
profitability  and return on equity) is not currently  appropriate in evaluating
the performance of the Company's executive officers. Consequently, in evaluating
the  performance  of management  the  Committee  takes into  consideration  such
factors as the Company's achieving specified milestones or goals in its clinical
development  and  research  programs.  In  addition,  the  Committee  recognizes
performance and  achievements  that are more difficult to quantify,  such as the
successful  supervision of major  corporate  projects,  demonstrated  leadership
ability and contributions to the industry and community  development.  For 1995,
the Committee  included in its evaluation the  significant  progress made by the
Company,   including  the  continuing  advancement  of  the  Company's  clinical
development of its products.

     Base compensation is established  through  negotiation  between the Company
and the  executive  officer  at the  time  the  executive  is  hired,  and  then
subsequently adjusted when such officer's base compensation is subject to review
or  reconsideration.  While the Company has entered into  employment  agreements
with  certain of its  executive  officers,  such  agreements  provide  that base
salaries  after the  initial  year will be  determined  by the  Committee  after
review.  When  establishing  or  reviewing  base  compensation  levels  for each
executive officer, the Committee, in accordance with its

                                      -10-

<PAGE>  14



general   compensation  policy,   considers  numerous  factors,   including  the
responsibilities  relating to the position,  the qualifications of the executive
and the relevant  experience  the  individual  brings to the Company,  strategic
goals for which the executive has  responsibility,  and  compensation  levels of
companies at a comparable  stage of development who compete with the Company for
business,  scientific,  and executive talents.  As stated above, such comparable
companies are generally  those with similar market  capitalizations  and are not
necessarily  among the  companies  comprising  the Nasdaq  Pharmaceutical  Index
reflected in the performance  graph in this Proxy Statement.  No  pre-determined
weights  are  given  to any one of  such  factors.  The  base  salaries  for the
executive officers generally, and the Chief Executive Officer specifically,  for
fiscal 1995 were comparable to the Company's peer group companies.

     In addition to each executive  officer's base  compensation,  the Committee
may award cash bonuses and/or grant awards under the Company's  Employee  Option
Plan to chosen  executive  officers  depending  on the  extent to which  certain
defined personal and corporate  performance  goals are achieved.  Such corporate
performance  goals  are the  same as  discussed  above.  Because  the  Company's
products are still in the early stages of  development,  the Company has granted
minimal bonuses to its executive officers.

     All  employees  of the  Company,  including  its  executive  officers,  are
eligible to receive  long-term stock based incentive  awards under the Company's
Employee Option Plan as a means of providing such  individuals with a continuing
proprietary  interest in the  Company.  Such grants  further  the  mutuality  of
interest  between the  Company's  employees  and its  stockholders  by providing
significant incentives for such employees to achieve and maintain high levels of
performance.  The Company's  Employee Option Plan enhances the Company's ability
to attract and retain the services of qualified individuals.  Factors considered
in  determining  whether such awards are granted to an executive  officer of the
Company include the executive's  position in the Company, his or her performance
and responsibilities, the amount of stock options, if any, currently held by the
officer,  the vesting schedules of any such options and the executive  officer's
other  compensation.   While  the  Committee  does  not  adhere  to  any  firmly
established  formulas or schedules for the issuance of awards such as options or
restricted  stock,  the Committee  will  generally  tailor the terms of any such
grant to achieve  its goal as a long-term  incentive  award by  providing  for a
vesting  schedule  encompassing  several  years or tying  the  vesting  dates to
particular corporate or personal milestones. For example, Gillian Ivers-Read was
granted options to acquire an aggregate of 33,750 shares of Common Stock in 1995
in  recognition  of her  continuing  contributions  to the Company  (see "Option
Grants in 1995" in this Proxy Statement).

     The annual base  salary of James M.  Chubb,  Ph.D.,  the  President  of the
Company,  was  initially  set at $212,000  pursuant to an  employment  agreement
effective  September  11, 1995.  Dr. Chubb  received a grant of 50,000 shares of
Common  Stock upon the  commencement  of his  employment  with the  Company,  in
connection  with which the Company  agreed to reimburse Dr. Chubb for his income
taxes  incurred  with respect to such grant.  Additionally,  Dr. Chubb  received
options to purchase 250,000 shares of Common Stock in September 1995.

     Section  162(m) of the  Internal  Revenue  Code of 1986,  as  amended  (the
"Code"),  added by the Revenue  Reconciliation  Act of 1993, places a $1 million
cap on the  deductible  compensation  that can be paid to certain  executives of
publicly-traded  corporations.  Amounts  that  qualify  as  "performance  based"
compensation under Section  162(m)(4)(c) of the Code are exempt from the cap and
do not count toward the $1 million limit. Generally,  stock options will qualify
as performance  based  compensation.  The Committee has discussed and considered
and will  continue to evaluate  the  potential  impact of Section  162(m) on the
Company in making  compensation  determinations,  but has not  established a set
policy with respect to future compensation determinations.

     The foregoing report is given by the following  members of the Compensation
Committee:

                                Ronald J. Brenner
                               George B. Mackaness
                                 Gregory F. Zaic

     The report of the Compensation  Committee shall not be deemed  incorporated
by  reference by any general  statement  incorporating  by reference  this Proxy
Statement into any filing under the Securities Act of 1933, as amended, or under

                                      -11-

<PAGE>  15



the  Exchange  Act,   except  to  the  extent  that  the  Company   specifically
incorporates  this  information by reference,  and shall not otherwise be deemed
filed under such Acts.


                             EXECUTIVE COMPENSATION

EXECUTIVE OFFICERS

     Set forth below is certain information concerning the executive officers of
the  Company,  including  the business  experience  of each during the past five
years.
<TABLE>
<CAPTION>

         Name                    Age            Position with the Company
         ----                    ---            -------------------------
<S>                              <C>    <C>  
James M. Chubb, Ph.D...........  48     President and Director (Class III)
Gillian Ivers-Read.............  43     Vice President, Pharmaceutical Development
Paul A. Cossum, Ph.D...........  43     Vice President, Preclinical Research and Development
Terance A. Murnane.............  45     Controller and Secretary
</TABLE>

     Information  regarding  the business  experience  of Dr. Chubb is set forth
above under the heading "Proposal Number 1: Election of Directors--Nominees  for
Director."

     Gillian  Ivers-Read  joined the  Company as Vice  President  of  Regulatory
Affairs  in  April  1994  and  assumed  the   position  of  Vice   President  of
Pharmaceutical  Development of the Company in September  1995.  Prior to joining
the  Company,  she  worked  for  Marion  Merrell  Dow,  where she most  recently
concentrated  on  regulatory  affairs in the anti-  viral,  anti-infective,  and
oncology therapeutic areas. She has been in the pharmaceutical industry for over
20 years,  having  worked for three major  companies  during  that time  (Marion
Merrell  Dow,  Wyeth  and  Rhone  Poulenc).  In  addition,  Mrs.  Ivers-Read  is
experienced  in  international  drug  development,  having  worked in the United
Kingdom  until  her  transfer  to the  United  States  in  1987.  She  has  been
responsible for  Investigational  New Drug applications  ("INDs") as well as New
Drug Applications ("NDAs") internationally.

     Paul A. Cossum,  Ph.D.  joined  Triplex as Vice  President  of  Preclinical
Development  in 1993 and assumed the position of Vice  President of  Preclinical
Research and Development of the Company in September 1995 upon the  consummation
of  the  Mergers.  From  1992  to  1993,  he was  the  Director  of  Preclinical
Development at Isis Pharmaceuticals.  While at Isis, he implemented  preclinical
programs to support the  development of INDs for two anti-viral  oligonucleotide
compounds.  Prior to his employment at Isis, Dr. Cossum worked in the Department
of Pharmacological Sciences at Genentech,  Inc., where he filed several INDs and
obtained an NDA for certain endocrine, cardiovascular and neurologic therapeutic
proteins.  He has published widely in the fields of metabolism and toxicology of
oligonucleotides, recombinant proteins, and conventional drugs.

     Terance A. Murnane joined the Company in May 1990 as its Controller and was
appointed Secretary in January 1992. Mr. Murnane was a self-employed  accountant
from  February  1988 until April 1990.  From October 1987 to February  1988,  he
served as the  accountant  for Eads  Company,  a wholesale  vendor of industrial
products based in Houston,  Texas. Prior to that time, he spent ten years in the
Private  Business/Audit  Department  at  KPMG  Peat  Marwick,  an  international
accounting  firm,  serving most  recently as Senior  Manager.  Mr.  Murnane is a
Certified Public Accountant.


                                      -12-

<PAGE>  16



COMPENSATION OF EXECUTIVE OFFICERS

     Summary Compensation Table

     The  following  table  provides  certain  summary  information   concerning
compensation  paid or  accrued  during  the last  three  years to the  Company's
President and to each of the other executive officers of the Company, determined
as of the end of the  last  fiscal  year,  whose  annual  compensation  exceeded
$100,000 (the "Named Executive Officers"):


<TABLE>
                                                                               LONG-TERM
                                                 ANNUAL COMPENSATION          COMPENSATION
                                                 -------------------          ------------
<CAPTION>
                                                                          RESTRICTED
                                                                           STOCK                      ALL OTHER
                                     YEAR     SALARY         BONUS         AWARDS        OPTIONS     COMPENSATION
                                     ----     ------         -----         ------        -------     ------------
<S>                                  <C>    <C>           <C>            <C>            <C>       <C>

James M. Chubb, Ph.D .............   1995   $ 61,833(1)       --         $106,250(2)    250,000   $ 42,075(3)
   President
Gillian Ivers-Read ...............   1995   $127,789          --             --          33,750       --
   Vice President, Development ...   1994   $ 94,718      $ 34,000(4)    $ 28,291(5)     50,000       --
Paul A. Cossum, Ph.D .............   1995   $ 46,667(6)       --             --          40,000   $ 17,000(7)
   Vice President, Preclinical R&D
David M. Leech(8) ................   1995   $126,570          --             --            --     $186,000(9)
   Former President and Chief ....   1994   $186,000      $ 23,000           --            --         --
   Executive Officer .............   1993   $178,750      $ 65,000(10)       --            --         --
<FN>

- - ----------------                                                                                              

(1)  Dr. Chubb  joined the Company as  President in September  1995 at an annual
     salary of $212,000.
(2)  Represents  a stock  bonus of 50,000  shares of Common  Stock  issued  upon
     commencement of employment and recorded at fair market value at the time of
     issuance.
(3)  Represents  the estimated  amount of federal  income taxes  incurred by Dr.
     Chubb in  connection  with the grant of 50,000  shares of Common Stock that
     the Company has agreed to reimburse in 1996.
(4)  Represents  a  $25,000  cash  signing  bonus  paid  to  Ms.  Ivers-Read  on
     commencement of her employment and a 1994 cash performance  bonus of $9,000
     accrued at December 31, 1994.
(5)  Represents  moving and  relocation  expenses  related  to Ms.  Ivers-Read's
     employment agreement.
(6)  Dr.  Cossum  joined the Company as Vice  President in September  1995 at an
     annual salary of $160,000.
(7)  Represents  the  forgiveness  of a portion of the  balance of a loan to Dr.
     Cossum.
(8)  Mr. Leech resigned as President of the Company in September 1995.
(9)  Represents  severance  paid  in  accordance  with  Mr.  Leech's  employment
     agreement.
(10) Represents a 1992 cash performance  bonus of $25,000 paid in April 1993 and
     a 1993 cash performance bonus of $40,000 accrued at December 31, 1993.

</FN>
</TABLE>


                                      -13-

<PAGE>  17



     Option Grants in 1995

         The  following  table  provides  certain  information  with  respect to
options  granted to the  President and to each of the Named  Executive  Officers
during the fiscal year ended  December 31, 1995 under the  Company's  1989 Stock
Option Plan:

<TABLE>
<CAPTION>
                                                                      Potential Realizable
                                                                        Value at Assumed
                                                                    Annual Rates of Stock Price
                                       Individual Grants           Appreciation for Option Term(1)
                                       -----------------           -------------------------------
                              Percent 
                              of Total 
                              Options              
                             Granted to           Market
                             Employees          Price on  Expir-
                    Options  in Fiscal  Exercise Date of  ation
Name                Granted    Year      Price    Grant   Date       0%      5%        10% 
- - ----                -------    ----      -----    -----   ----       --      --        ---
<S>               <C>         <C>        <C>      <C>    <C>      <C>       <C>       <C>
    
James M. Chubb    250,000(2)  26.4% $    2.12$    3.62   9/28/02  $376,250  $744,444  $1,223,396

Gillian            33,750(3)   3.6% $    2.12$    3.88   9/21/02   $59,231  $112,372   $ 181,484
 Ivers-Read 
Paul A. Cossum     40,000(3)   4.2% $    2.12$    3.88   9/21/02   $70,200  $133,182   $ 215,092
</TABLE>
- - ----------
(1)     The  Securities  and  Exchange  Commission  requires  disclosure  of the
        potential   realizable  value  or  present  value  of  each  grant.  The
        disclosure  assumes the options will be held for the full  ten-year term
        prior to exercise.  Such  options may be  exercised  prior to the end of
        such ten-year term. The actual value,  if any, an executive  officer may
        realize will depend upon the excess of the stock price over the exercise
        price on the date the  option is  exercised.  There can be no  assurance
        that the stock price will appreciate at the rates shown in the table.
(2)     These options vest in equal monthly installments over four years.
(3)     These options vest in equal annual installments over four years.



                                      -14-

<PAGE>  18



Performance Graph

         The  following  performance  graph  compares  the  performance  of  the
Company's  Common Stock to the Nasdaq Composite Index and to the Nasdaq Index of
Pharmaceutical  Companies.  The graph  covers the period from July 10, 1992 (the
date on which the Company's  Common Stock was registered  under Section 12(g) of
the Exchange Act), to December 31, 1995. The graph assumes that the value of the
investment in the Company's Common Stock and each index was 100 at July 10, 1992
and that all dividends were reinvested.


                    PERFORMANCE GRAPH APPEARS HERE PLOTTED
                    BASED UPON THE NUMBERS SET FORTH BELOW.
                    
                           7/10/92   12/31/92   12/31/93   12/31/94   12/31/95
Aronex                      100.00    120.69       68.97     29.31      60.34
Nasdaq Composite Index      100.00    121.12      139.04    135.91     192.05
Nasdaq Pharmaceutical Index 100.00    114.59      102.14     76.89     140.44

         The foregoing stock price  performance  comparisons shall not be deemed
incorporated by reference by any general  statement  incorporating  by reference
this  Proxy  Statement  into any filing  under the  Securities  Act of 1933,  as
amended,  or under the  Exchange  Act,  except to the  extent  that the  Company
specifically  incorporates  this graph by reference,  and shall not otherwise be
deemed filed under such acts.

         There can be no assurance  that the Company's  stock  performance  will
continue into the future with the same or similar  trends  depicted in the graph
above.  The Company will not make or endorse any  predictions as to future stock
performance.


                                      -15-

<PAGE>  19



EMPLOYMENT AGREEMENTS

         The Company has entered into employment  agreements with Dr. Chubb, Ms.
Ivers-Read, Dr. Cossum and a senior director-clinical research which provide for
current salaries of $212,000, $135,000, $160,000 and $127,000,  respectively. In
addition,   these  agreements  also  provide  for  the  payment  of  such  bonus
compensation  as  may be  awarded  by the  Board  of  Directors  and  for  their
participation  in all employee  benefit  plans  sponsored  by the  Company.  The
employment  agreements  for Drs.  Chubb and Cossum have a primary term ending in
September 1996 and November 1996,  respectively,  with automatic  annual renewal
unless  terminated by either party.  The  employment  agreements  for the senior
director-clinical  research and Ms. Ivers-Read have primary terms of three years
ending in April and May  1997,  respectively,  with  automatic  annual  renewals
unless terminated by either party. All of such agreements provide for payment of
an amount equal to one year's annual base salary and the provision of employment
benefits  following  termination  other than for cause.  The agreement  with Dr.
Chubb requires the Company to purchase  $960,000 in term life insurance  payable
to a  beneficiary  of his choosing and to pay his annual dues to a country club.
Dr. Cossum's  agreement  provided for the forgiveness of one half of the balance
of a loan from the Company in January 1996 and provides for the  forgiveness  of
the remaining balance  (approximately  $17,000 as of March 31, 1996) in the next
two years, subject to the accomplishment of agreed upon goals.

401(K) PLAN

         The Company maintains a retirement  savings plan,  effective as amended
on January 1, 1991,  in which any employee of the Company who has  completed one
month of employment may elect to participate.  The plan is an individual account
plan providing for deferred  compensation  as described in Section 401(k) of the
Internal  Revenue  Code of 1986,  as amended (the "Code") and is subject to, and
intended to comply with, the Employee Retirement Income Security Act of 1974, as
amended.  Each  eligible  employee is permitted to  contribute  up to 20% of his
annual salary up to the applicable statutory maximum prescribed in the Code. The
Company may, in its  discretion,  contribute  an amount equal to the  employee's
contribution,  but such Company  contribution  may not exceed an amount equal to
six percent of the employee's  compensation.  A participant is 50% vested in the
accrued  benefits derived from the Company's  contributions  after completion of
one year of employment  following his election to  participate  in the plan, and
100% vested in such  contributions  after  completion of two years of employment
following such election. Participants may receive hardship loans under the terms
of the plan.  The plan  provides for  distributions  in the event a  participant
dies, reaches the age of 65, becomes disabled or terminates his employment prior
to the age of 65. The Company made contributions of approximately  $26,000 under
the 401(k) plan in 1995.

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

         Martin P.  Sutter,  the  Chairman  of the Board and  co-founder  of the
Company,  served on the Compensation  Committee of the Board of Directors during
the year ended December 31, 1995.  Mr. Sutter served as the Company's  President
from its inception to October 1988.

         Ronald J.  Brenner and Gregory F. Zaic,  each of whom has served on the
Compensation  Committee since 1995, are general partners of limited partnerships
that, in turn, are the general partners of limited  partnerships  that received,
in  exchange  for  preferred  stock of Triplex  in the  Triplex  merger,  (i) an
aggregate  of  1,986,540  and  674,831  shares of the  Company's  Common  Stock,
respectively,  and (ii) the right to receive  additional  shares of Common Stock
contingent upon the occurrence of certain events.

                              CERTAIN TRANSACTIONS

         The Company has a consulting  agreement  with Gabriel  Lopez-Berestein,
M.D.,  whereby the Company is committed to pay  consulting  fees of $144,000 and
$156,000 for 1996 and 1997,  respectively.  The Company paid Dr. Lopez-Berestein
$132,000 under the agreement during the year ended December 31, 1995.


                                      -16-

<PAGE>  20



         The Company and its  predecessor  Triplex  paid  $46,033 and $66,500 to
Plexus Ventures, Inc. ("Plexus") for 1994 and 1995, respectively,  in connection
with the Company's location of development and merger partners.  The Company had
a consulting  agreement with Plexus  Ventures,  Inc. which terminated on October
31, 1996  whereby the Company is  committed  to pay a fee to Plexus in the event
the Company  enters into a  development  collaboration  for  NyotranTM  prior to
October  31,  1996 with a company  identified  by Plexus.  John F.  Chappell,  a
director of the Company,  is the sole  shareholder and has been the President of
Plexus since 1990.

         Certain other  transactions  with related  parties are described  under
"Compensation Committee Interlocks and Insider Participation."

         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

         The  following  table  presents  certain   information   regarding  the
beneficial  ownership of the Company's  Common Stock as of March 31, 1996 by (i)
each  person  who is known by the  Company  to own  beneficially  more than five
percent of the  outstanding  shares of Common  Stock,  (ii) each director of the
Company, (iii) the Company's chief executive officer and each of the other Named
Executive  Officers and (iv) all directors  and  executive  officers as a group.
Except as  described  below,  each of the  persons  listed in the table has sole
voting and investment power with respect to the shares listed.
<TABLE>
<CAPTION>
                                                                      
                                                                          
                                                 Number of Shares  Percentage of
 Shares                                           of Common Stock      Shares
                                                  Beneficially      Beneficially
Name                                                 Owned             Owned
- - ----                                                 -----             -----
<S>                                                   <C>                 <C>   
Amerindo Investment Advisors, Inc. (1).............   2,015,000           9.3%
   One Embarcadero Center, Suite 2300
   San Francisco, California 94111
Hillman Medical Venture Partnerships (2)...........   1,986,540           9.2%
   824 Market Street, Suite 900
   Wilmington, Delaware 19801
HealthCare Ventures Partnerships (3)...............   1,917,103           8.8%
   Twin Towers at Metro Bank
   379 Thornall Street
   Edison, New Jersey 08837
The Allstate Corporation (4).......................   1,533,928           7.1%
   2775 Sanders Road
   Northbrook, Illinois 60062
Martin P. Sutter (5) (11)..........................     932,704           4.3%
James M. Chubb (6).................................     232,381           1.1%
Gabriel Lopez-Berestein (7)(11)....................     222,587           1.0%
George B. Mackaness (11)...........................      80,000              *
Ronald J. Brenner (8)(11)..........................   2,028,410           9.3%
Geoffrey F. Cox (9)(11)............................     873,611           4.0%
Gregory F. Zaic (10)(11)...........................     701,831           3.2%
John F. Chappell (11)..............................      36,809              *
Paul A. Cossum (12)................................      28,140              *
Gillian Ivers-Read (12)............................      23,750              *
All directors and officers as a group
   (11 persons) (5)-(12)...........................   5,174,195          23.8%
</TABLE>
- - ---------------------------

*      Less than one percent.

(1)  Consists of 1,917,500 shares owned by Amerindo  Investment  Advisors,  Inc.
     ("Amerindo"),  77,500  shares  owned by Amerindo  Advisors  (U.K.)  Limited
     ("Amerindo  UK"), and 20,000 shares owned by Amerindo  Investment  Advisors
     Inc. Profit Sharing Trust ("Plan").  The sole shareholders and directors of
     Amerindo and  Amerindo UK are Alberto W. Vilar and Gary A. Tanaka,  each of
     whom may by deemed to be the beneficial owner of the 1,995,000 shares owned
     by Amerindo  and Amerindo UK. Mr. Vilar is sole trustee of the Plan and may
     be deemed


                                      -17-

<PAGE>  21



     to be the  beneficial  owner of the 20,000 shares owned by the Plan.  Based
     on Schedule  13G,  Amendment  No. 1, dated  February  15,  1996,  of 
     Amerindo, Amerindo UK, the Plan, Mr. Vilar and Mr. Tanaka.
(2)  Consists of 236,180  shares owned by Hillman  Medical  Ventures  1989 L.P.,
     738,114  shares owned by Hillman  Medical  Ventures 1990 L.P. and 1,012,246
     shares  owned by Hillman  Medical  Ventures  1991 L.P.  (collectively,  the
     "Hillman  Medical  Venture  Partnerships").  The  general  partners  of the
     Hillman Medical Venture Partnerships are Cashon Biomedical Associates, L.P.
     and Hillman/Dover Limited Partnership. The general partner of Hillman/Dover
     Limited Partnership is a wholly-owned  subsidiary of The Hillman Company, a
     firm engaged in diversified investments and operations. The Hillman Company
     is  controlled  by  Henry  L.  Hillman,  Elsie  Hilliard  Hillman  and C.G.
     Grefenstette, Trustees of the Henry L. Hillman Trust, which Trustees may be
     deemed the beneficial  owners of the 1,986,540  shares owned by the Hillman
     Medical Venture  Partnerships.  Dr. Brenner, a director of the Company,  is
     the managing partner of Cashon  Biomedical  Associates,  L.P., of which the
     other general  partners are Hal S.  Broderson,  M.D. and Charles G. Hadley.
     Dr. Brenner, Dr. Broderson and Mr. Hadley may be deemed to beneficially own
     such shares.
(3)  Consists of 489,246  shares  owned by  HealthCare  Venture  Partners  L.P.,
     382,356 shares owned by HealthCare Venture Partners II L.P., 808,199 shares
     owned by HealthCare  Venture  Partners III L.P. and 237,302 shares owned by
     HealthCare Venture Partners IV L.P. (collectively,  the "HealthCare Venture
     Partnerships").  James H. Cavanaugh, Harold R. Werner, John W. Littlechild,
     Ronald  Shipman  and  William  Crouse are  general  partners of each of the
     HealthCare Venture  Partnerships and may be deemed to beneficially own such
     shares.
(4)  Consists of 1,533,928 shares owned by Allstate  Insurance Company, a wholly
     owned  subsidiary  of The  Allstate  Corporation,  based on  Schedule  13G,
     Amendment No. 3, dated February 9, 1996, of The Allstate Corporation.
(5)  Includes  893,704  shares owned by The Woodlands  Venture Fund,  L.P.,  and
     1,000 shares owned by The Woodlands Venture Partners,  L.P. Mr. Sutter is a
     general  partner of The  Woodlands  Venture  Partners,  L.P.,  which is the
     general partner of The Woodlands  Venture Fund,  L.P. Mr. Sutter  disclaims
     beneficial  ownership of the 893,704 shares owned by The Woodlands  Venture
     Fund,  L.P.  Also  includes  37,000  shares  which may be  acquired  on the
     exercise of the currently vested portion of stock options.
(6)  Includes  91,031  shares  that may be  acquired  on the  exercise  of stock
     options.
(7)  Includes  91,364  shares  that may be  acquired  on the  exercise  of stock
     options.  Includes  55,000  shares that may be acquired on the  exercise of
     stock options  granted  subject to stockholder  approval prior to issuance.
     The Company  intends to seek such  approval  at its 1996 annual  meeting of
     stockholders.   Excludes   39,394   shares   held  by  a  relative  of  Dr.
     Lopez-Berestein, but as to which he disclaims beneficial ownership.
(8)  Includes   1,986,540   shares   owned  by  the  Hillman   Medical   Venture
     Partnerships,  of which Dr.  Brenner is the managing  partner of one of the
     general partners.
(9)  Includes  846,611  shares owned by Genzyme  Corporation.  Dr. Cox is Senior
     Vice President of Genzyme.  Dr. Cox disclaims  beneficial  ownership of the
     shares held by Genzyme.
(10) Includes 674,831 shares owned by Prince Venture Partners III, L.P. Mr. Zaic
     is a general partner of Prince  Ventures,  L.P., which is a general partner
     of  Prince  Venture  Partners  III,  L.P.  Mr.  Zaic  disclaims  beneficial
     ownership of the shares held by Prince Venture Partners III, L.P.
(11) Includes  25,000  shares  that may be  acquired  on the  exercise  of stock
     options  granted  subject to  stockholder  approval of the Amendment to the
     Director Plan at the Annual Meeting.
(12) Represents shares that may be acquired on the exercise of stock options.

     The holders of an aggregate  of  approximately  9,669,616  shares of Common
Stock are parties to a Stockholders  Agreement.  Those stockholders  include the
Hillman Medical Venture Partnerships,  the HealthCare Ventures Partnerships, The
Woodlands  Venture Fund, L.P., The Woodlands  Venture  Partners,  L.P.,  Genzyme
Corporation, Prince Venture Partners III, L.P. and Gabriel Lopez-Berestein.  The
Stockholders Agreement continues in effect until the later of (i) the completion
of the second annual meeting of  stockholders of the Company after September 11,
1995 and (ii) September 11, 1997.

                          COMPLIANCE WITH SECTION 16(a)

     Section 16(a) of the Securities Exchange Act of 1934, as amended,  requires
the Company's  directors and officers,  and persons who own more than 10% of the
Common  Stock,  to file initial  reports of ownership  and reports of changes in
ownership  (Forms 3, 4, and 5) of Common Stock with the  Securities and Exchange
Commission  (the "SEC") and The Nasdaq Stock  Market.  Officers,  directors  and
greater  than 10%  stockholders  are required by SEC  regulation  to furnish the
Company with copies of all such forms that they file.

     To the Company's  knowledge,  based solely on the  Company's  review of the
copies of such reports received by the Company and on written representations by
certain reporting  persons that no reports on Form 5 were required,  the Company
believes that during the fiscal year ended  December 31, 1995, all Section 16(a)
filing requirements applicable

                                      -18-

<PAGE>  22



to its officers,  directors and 10% stockholders  were complied with in a timely
manner, with the exception of one late filing on Form 4 by Geoffrey F. Cox.

                            PROPOSAL OF STOCKHOLDERS

     Any proposal of a  stockholder  intended to be presented at the next annual
meeting must be received at the Company's  principal  executive offices no later
than February 1, 1997, if the proposal is to be considered  for inclusion in the
Company's Proxy Statement relating to such meeting.

                              FINANCIAL INFORMATION

     A COPY OF THE COMPANY'S ANNUAL REPORT ON FORM 10-K, INCLUDING ANY FINANCIAL
STATEMENTS AND SCHEDULES AND EXHIBITS THERETO, MAY BE OBTAINED WITHOUT CHARGE BY
WRITTEN  REQUEST  TO  TERANCE  A.  MURNANE,  CONTROLLER  AND  SECRETARY,  ARONEX
PHARMACEUTICALS, INC., 3400 RESEARCH FOREST DRIVE, THE WOODLANDS, TEXAS 77381.


                                        By Order of the Board of Directors


                                        Terance A. Murnane
                                        Secretary



June 6, 1996
The Woodlands, Texas

<PAGE>  23

                          ARONEX PHARMACEUTICALS, INC.
           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                             TO BE HELD JULY 9, 1996

     The undersigned hereby appoints James M. Chubb and Terance A. Murnane,  and
each of them,  as proxies,  each with the power to appoint his  substitute,  and
hereby authorizes them to represent and vote, as designated on the reverse side,
all of the  shares of the  common  stock of Aronex  Pharmaceuticals,  Inc.  (the
"Company")  held of  record by the  undersigned  on May 15,  1996 at the  Annual
Meeting (the  "Annual  Meeting")  of  Stockholders  of the Company to be held on
Tuesday,  July 9, 1996,  at 1:00 p.m.,  local time,  in the Crockett Room of The
Woodlands Executive Conference Center, 2301 North Millbend Drive, The Woodlands,
Texas, and any adjournment(s) thereof.

                                     (To be Dated and Signed On Reverse Side)



<PAGE>  24                                                     

                                                                 WITHOLD
1.   To elect three Class III  directors  of the         FOR    AUTHORITY
     Company each to serve until the Company's
     1999 Annual  Meeting of  Stockholders               [  ]     [  ]
     or until their  respective  successors
     successors have been duly elected and qualified.
INSTRUCTION:  To withhold  authority is vote for any individual  nominee,  write
such name or names in the space provided below.]

                               Nominees:  Gregory F. Zaic  
- - ---------------------------               James M. Chubb, Ph.D.
                                          George B. Mackaness, M.D.



2.   To vote upon a proposal ro amend and  restate    FOR   AGAINST  ABSTAIN
     the Aronex  Pharmaceuticals, Inc. 1993           [  ]    [  ]     [  ]
     Non-Employee Director Stock Option Plan;


3.   To  ratify  and  approve  the  appointment       [  ]    [  ]     [  ]
     of Arthur  Andersen  LLP as the Company's 
     independent  public  accountants  for  its 
     fiscal year ending December 31, 1996; and


4.   To act upon such other business as may promptly
     come before the meeting or any adjournments thereof.

     Only  stockholders  of record at the close of business on May 15, 1996 will
be entitled to notice of and to vote at the Annual Meeting. 

     It is  important  that your  shares be  represented  at the Annual  Meeting
regardless of whether you plan to attend. THEREFORE,  PLEASE MARK, DATE AND SIGN
THIS PROXY AND RETURN IT IN THE  ACCOMPANYING  POSTPAID  ENVELOPE AS PROMPTLY AS
POSSIBLE.  If you are present at the Annual Meeting,  and wish to do so, you may
revoke the Proxy and vote in person.


SIGNATURE------------------------------------------- DATE ---------------- 

SIGNATURE------------------------------------------- DATE ---------------- 
                    Signature if held jointly

Note:  Please  execute this Proxy as your name appears  hereon.  When shares are
       held by joint  tenants,  both  should  sign.  When  signing as  attorney,
       executor,  administrator,  trustee or guardian, please give full title as
       such.  If a  corporation,  please  sign  in  full  corporate  name by the
       president or other authorized officer.  If a partnership,  please sign in
       partnership name by authorized person.






                                      -19-

<PAGE>  25


                                                            EXHIBIT A

                          ARONEX PHARMACEUTICALS, INC.
                     1993 AMENDED AND RESTATED NON-EMPLOYEE
                           DIRECTOR STOCK OPTION PLAN


         Aronex  Pharmaceuticals,  Inc., a Delaware  Corporation (the "Company")
hereby  amends and restates  its 1993  Non-Employee  Director  Stock Option Plan
(this  "Plan"),  effective  as of  November  14,  1995,  subject to  stockholder
approval.

                  1.       PURPOSE.

                  The  purpose  of  this  Plan is to  promote  and  advance  the
interests  of the  Company by aiding the  Company in  attracting  and  retaining
qualified  directors of the Company who, at the time of their  service,  are not
employees of the Company or any of its subsidiaries  ("Non-Employee Directors"),
and to further align the interests of such Non-Employee  Directors with those of
stockholders  through stock  options.  An additional  purpose of this Plan is to
recognize  and  reward  the  contributions  of  Non-Employee  Directors  who are
actively  involved in aspects of the  Company's  business  beyond  their role as
directors.

                  2.       ADMINISTRATION.

                  This Plan shall be administered by the Compensation  Committee
of the Board of Directors of the Company (the "Committee"),  which shall consist
of not less than two members of the Board of  Directors,  each of whom will be a
"disinterested  person"  within the meaning of Rule 16b-3 of the  Securities and
Exchange Commission (or any successor rule to the same effect) as in effect from
time to time and an "outside  director"  within the meaning of Section 162(m) of
the Internal Revenue Code of 1986, as amended.  For the purposes of this Plan, a
majority  of the  members of the  Committee  shall  constitute  a quorum for the
transaction of business,  and the vote of a majority of those members present at
any meeting shall decide any question brought before that meeting.  No member of
the Committee shall be liable for any act or omission of any other member of the
Committee  or for  any  act or  omission  on his own  part,  including  (without
limitation)  the  exercise  of any power or  discretion  given to him under this
Plan,   except  those  resulting  from  his  own  gross  negligence  or  willful
misconduct.  All questions of interpretation and application of this Plan, or as
to  options  granted  hereunder  (the  "Options"),   shall  be  subject  to  the
determination,  which  shall be final and  binding,  of a majority  of the whole
Committee.

                  3.       OPTION SHARES.

                  The stock subject to the Options and other  provisions of this
Plan shall be shares of the Company's  Common  Stock,  par value $.001 per share
(the "Common Stock"). The total amount of the Common Stock with respect to which
Options  may be  granted  shall not  exceed  600,000  shares  in the  aggregate;
provided,  that the class and aggregate number of shares which may be subject to
the Options granted  hereunder shall be subject to adjustment in accordance with
the provisions of Section 11 of this Plan. Such shares may be treasury shares or
authorized but unissued shares.

                  If any  outstanding  Option  for any  reason  shall  expire or
terminate  by reason of the death of the  optionee or the fact that the optionee
ceases to be a director,  the surrender of any such Option,  or any other cause,
the shares of Common Stock allocable to the  unexercised  portion of such Option
may again be subject to an Option under this Plan.

                  4.       GRANT OF OPTIONS.

                  (a)      Formula Grants.

                           (i) Directors on the Effective  Date of the Amendment
                  and  Restatement  of this Plan.  Subject to the  provisions of
                  Section 15 hereof,  there  shall be granted to each person who
                  is a  Non-Employee  Director,  upon the effective  date of the
                  amendment and  restatement of this Plan, an Option to purchase
                  25,000  shares of the Common Stock at a per share Option Price
                  equal to the fair  market  value  (as  defined  in  Subsection
                  4(a)(iv) below) of a share of Common Stock on such date.


                                         A-1

<PAGE>  26



                           (ii)  Directors  Elected after the Effective  Date of
                  the Amendment  and  Restatement  of this Plan.  Subject to the
                  provisions  of Section 15 hereof,  for so long as this Plan is
                  in effect and shares  are  available  for the grant of Options
                  hereunder, each person who is not otherwise an employee of the
                  Company,  and who is first  elected to the Board of  Directors
                  after the effective  date of the amendment and  restatement of
                  this Plan, shall be granted,  on the date of his election,  an
                  Option to purchase  25,000 shares of Common Stock (such number
                  of shares being subject to the adjustments provided in Section
                  11 of this Plan) at a per share Option Price equal to the fair
                  market value of a share of Common Stock on such date.

                           (iii) Annual Grants. On December 31 of each year that
                  this Plan is in effect  (commencing  with  December 31, 1996),
                  each  Non-Employee  Director  who is in  office  on  that  day
                  (provided  that such  Non-Employee  Director  has  served as a
                  director  for at least six months  prior to such  date)  shall
                  automatically  receive an Option to purchase  7,500  shares of
                  Common  Stock  (such  number of shares  being  subject  to the
                  adjustments  provided  in  Section  11 of this  Plan) at a per
                  share  Option  Price equal to the fair market value of a share
                  of Common Stock on such date.

                           (iv) Fair Market Value.  For purposes of this Section
                  4, the "fair  market  value" of a share of Common  Stock as of
                  any  particular  date shall  mean (i) if the  Common  Stock is
                  listed or admitted to trading on any securities exchange or on
                  the National  Association  of Securities  Dealers (the "NASD")
                  Automated  Quotation System  ("Nasdaq")  National Market,  the
                  closing price on such day on the principal securities exchange
                  or on the Nasdaq  National Market on which the Common Stock is
                  traded or quoted, or if such day is not a trading day for such
                  securities exchange or the Nasdaq National Market, the closing
                  price on the first  preceding day that was a trading day, (ii)
                  if the Common  Stock is not then listed or admitted to trading
                  on any securities  exchange or on the Nasdaq National  Market,
                  the closing bid price on such day as reported by the NASD,  or
                  if no such  price is  reported  by the NASD for such day,  the
                  closing  bid  price  as  reported  by the  NASD  on the  first
                  preceding day for which such price is available,  and (iii) if
                  the Common  Stock is not then listed or admitted to trading on
                  any securities  exchange or on the Nasdaq  National Market and
                  no  such  closing  bid  price  is  reported  by the  NASD,  as
                  determined by the Committee in good faith.

                           (v) No Discretion with Respect to Formula Grants. The
                  selection of Non-Employee  Directors to whom Options are to be
                  granted  pursuant to this Section  4(a),  the number of shares
                  subject to any such  Option,  the  exercise  price of any such
                  Option and the term of any such  Option  shall be as  provided
                  herein and the  Committee  shall have no discretion as to such
                  matters.

                  (b) Discretionary  Grants. The Committee may from time to time
authorize grants to any Non-Employee  Director  (provided that no such grant may
be made to a Non-Employee Director who is a member of the Committee, and that no
such grant may be made that would  prevent  the  members of the  Committee  from
constituting  "disinterested  persons"  within  the  meaning  of Rule  16b-3) of
Options to purchase  shares of Common Stock upon such terms and conditions as it
may determine in accordance with the following provisions:

                         (i) Each  grant  will  specify  the number of shares of
                    Common Stock to which the Option granted pertains.

                         (ii) Each grant will  specify  the Option  Price of the
                    Option, which may be less than, equal to or greater than the
                    fair market value of a share of Common Stock on the date of
                  grant.

                         (iii) Each grant may  specify  the  required  period or
                    periods  of  continuous  service  by the  grantee  with  the
                    Company  and/or the other  conditions  of  vesting  (if any)
                    before  the  Option  or  installments  thereof  will  become
                    exercisable.

                  (c) Outstanding Options. The amendment and restatement of this
Plan shall not affect the terms and conditions of any Options  (including  terms
relating  to the vesting and term  thereof)  outstanding  under this Plan on the
effective date of such amendment and restatement.


                                       A-2

<PAGE>  27




                  5.       VESTING AND TERM OF OPTIONS.

                  Each Option granted under Section 4(a) of this Plan shall vest
in full and be exercisable to purchase all of the shares of Common Stock subject
to the  Option on the date on which the  Option  was  granted,  and each  Option
granted  under  Section  4(b) of this  Plan  shall  vest and be  exercisable  to
purchase the number of shares  subject to the Option at such times and upon such
conditions as may be established by the Committee on the date of grant,  subject
in each case to earlier  termination as provided in Section 8 of this Plan. Each
Option granted under this Plan shall expire on the tenth anniversary of the date
on which the Option was granted.

                  6.       EXERCISE OF OPTIONS.

                  An  optionee  may  exercise  his Option by  delivering  to the
Company a written notice stating (a) that such optionee  wishes to exercise such
Option on the date  such  notice is so  delivered,  (b) the  number of shares of
Common Stock with  respect to which such Option is to be  exercised  and (c) the
address to which the  certificate  representing  such shares of stock  should be
mailed. To be effective,  such written notice shall be accompanied by payment of
the Option Price of each of such shares of Common Stock. Each such payment shall
be made by cash,  cashier's  check or bank  draft  drawn on a  national  banking
association  or postal  or  express  money  order,  payable  to the order of the
Company in United States dollars.

                  Any  Option  granted  under  the  Plan may be  exercised  by a
broker-dealer  acting on  behalf of an  optionee  if (i) the  broker-dealer  has
received from the optionee or the Company a duly endorsed  agreement  evidencing
such Option and  instructions  signed by the optionee  requesting the Company to
deliver the shares of Common Stock  subject to such Option to the  broker-dealer
on behalf of the  Participant  and specifying the account into which such shares
should be deposited,  (ii) adequate  provision has been made with respect to the
payment  of  any   withholding   taxes  due  on  such  exercise  and  (iii)  the
broker-dealer and the optionee have otherwise complied with Section  220.3(e)(4)
of Regulation T, 12 CFR Part 220.

                  As promptly as  practicable  after the receipt by the Company,
in the form required by the foregoing  provisions of this Section 6, of (a) such
written  notice from the optionee  and (b)  payment,  of the Option Price of the
shares of stock  with  respect  to which  such  Option is to be  exercised,  the
Company shall deliver to such optionee a certificate  representing the number of
shares  of  stock  with  respect  to which  such  Option  has been so  exercised
registered in the name of such  optionee,  provided that such delivery  shall be
considered  to have  been made when such  certificate  shall  have been  mailed,
postage prepaid,  to such optionee at the address  specified for such purpose in
such written notice from the optionee to the Company.

                  7.       TRANSFERABILITY OF OPTIONS.

                  Options shall not be  transferable  by the optionee  otherwise
than by will or under the laws of descent and distribution.

                  8.       TERMINATION.

                  Except as may be otherwise  expressly provided in this Plan or
otherwise  determined by the Committee,  each Option, to the extent it shall not
have  been  exercised  previously,  shall  terminate  on  the  earliest  of  the
following:

                           (a) On the last day of the 24 month period commencing
                  on the date on which the optionee ceases to be a member of the
                  Company's  Board of  Directors,  for any reason other than the
                  death of the optionee,  during which period the optionee shall
                  be entitled to exercise  all Options  held by the  optionee on
                  the date on which  the  optionee  ceased to be a member of the
                  Company's  Board of Directors  which could have been exercised
                  on such date;

                           (b)  On  the  last  day  of  the   six-month   period
                  commencing on the date of the  optionee's  death while serving
                  as a member of the Company's Board of Directors,  during which
                  period the executor or administrator of the optionee's  estate
                  or the person or persons to whom the  optionee's  Option shall
                  have  been  transferred  by will or the  laws  of  descent  or
                  distribution,  shall be entitled  to  exercise  all Options in
                  respect of the number of shares that the  optionee  would have
                  been  entitled to purchase  had the  optionee  exercised  such
                  Options on the date of his death; or


                                       A-3

<PAGE>  28




                         (c) Ten years after the date of grant of such Option.

                  9.       Requirements of Law.

                  The Company  shall not be required to sell or issue any shares
under any Option if the issuance of such shares shall  constitute a violation by
the optionee or the Company of any  provisions  of any law or  regulation of any
governmental authority.  Each Option granted under this Plan shall be subject to
the  requirement  that,  if at any time the Board of Directors of the Company or
the  Committee   shall   determine  that  (i)  the  listing,   registration   or
qualification  of the shares  subject  thereto upon any  securities  exchange or
under any state or federal law of the United  States or of any other  country or
governmental   subdivision  thereof,   (ii)  the  consent  or  approval  of  any
governmental  regulatory  body,  or (iii)  the  making  of  investment  or other
representations,  are  necessary or desirable  in  connection  with the issue or
purchase of shares subject thereto,  no such Option may be exercised in whole or
in part unless such listing, registration,  qualification,  consent, approval or
representation  shall have been effected or obtained free of any  conditions not
acceptable to the Board of Directors.  Any  determination  in this connection by
the Committee shall be final, binding and conclusive.  If the shares issuable on
exercise of an Option are not  registered  under the Securities Act of 1933, the
Company may imprint on the certificate  for such shares the following  legend or
any legend  which  counsel for the Company  considers  necessary or advisable to
comply with the Securities Act of 1933:

         THE  SHARES  OF STOCK  REPRESENTED  BY THIS  CERTIFICATE  HAVE NOT BEEN
         REGISTERED  UNDER THE  SECURITIES  ACT OF 1933 OR UNDER THE  SECURITIES
         LAWS OF ANY STATE AND MAY NOT BE SOLD OR  TRANSFERRED  EXCEPT UPON SUCH
         REGISTRATION  OR UPON  RECEIPT  BY THE  CORPORATION  OF AN  OPINION  OF
         COUNSEL  SATISFACTORY  TO  THE  CORPORATION,   IN  FORM  AND  SUBSTANCE
         SATISFACTORY TO THE CORPORATION,  THAT REGISTRATION IS NOT REQUIRED FOR
         SUCH SALE OR TRANSFER.

The Company may, but shall in no event be obligated to,  register any securities
covered  hereby  pursuant to the  Securities Act of 1933 (as now in effect or as
hereinafter  amended)  and,  if any shares are so  registered,  the  Company may
remove any legend on certificates  representing  such shares.  The Company shall
not be obligated to take any other  affirmative  action to cause the exercise of
an Option or the issuance of shares  pursuant  thereto to comply with any law or
regulation or any governmental authority.

                  10.      NO RIGHTS AS STOCKHOLDER.

                  No optionee shall have rights as a stockholder with respect to
shares  covered by his Option until the date of issuance of a stock  certificate
for such  shares;  and,  except as otherwise  provided in Section 11 hereof,  no
adjustment  for  dividends,  or  otherwise,  shall  be made if the  record  date
therefor is prior to the date of issuance of such certificate.

                  11.      CHANGES IN THE COMPANY'S CAPITAL STRUCTURE.

                  The existence of  outstanding  Options shall not affect in any
way the right or power of the Company or its  stockholders  to make or authorize
any of all adjustments,  recapitalizations,  reorganizations or other changes in
the Company's  capital  structure or its business or any merger or consolidation
of the Company, or any issue of bonds, debentures, preferred or prior preference
stock  ahead of or  affecting  the Common  Stock or the rights  thereof,  or the
dissolution or liquidation of the Company, or any sale or transfer of all or any
part of its  assets or  business,  or any  other  corporate  act or  proceeding,
whether of a similar character or otherwise.

                  If the Company shall effect a subdivision or  consolidation of
shares or other capital  readjustment,  the payment of a stock dividend or other
increase or reduction  of the number of shares of the Common Stock  outstanding,
without receiving  consideration  therefor in money, services or property,  then
(a) the  number,  class  and per  share  price of  shares  of stock  subject  to
outstanding  Options hereunder shall be appropriately  adjusted in such a manner
as to entitle an optionee to receive  upon  exercise of an Option,  for the same
aggregate  cash  consideration,  the same  total  number and class or classes of
shares as he would have received had he exercised his Option in full immediately
prior to the event  requiring  the  adjustment;  and (b) the number and class of
shares then reserved for issuance under this Plan and the number of shares to be
subject to the grants to be made pursuant to Section 4(a)(ii) and (iii) shall be
adjusted by substituting  for the total number and class of shares of stock then
reserved or subject to grant the number and class or


                                       A-4

<PAGE>  29



classes  or shares of stock that  would  have been  received  by the owner of an
equal  number of  outstanding  shares of Common Stock as the result of the event
requiring the adjustment, disregarding any fractional shares.

                  If  the   Company   merges  or   consolidates   with   another
corporation,  whether or not the Company is a surviving  corporation,  or if the
Company is liquidated or sells or otherwise disposes of substantially all of its
assets while unexercised  Options remain  outstanding under this Plan, or if any
"person" (as that term is used in Section  13(d) and 14(d)(2) of the  Securities
Exchange  Act  of  1934)  is  or  becomes  the  beneficial  owner,  directly  or
indirectly,  of securities of the Company  representing  greater than 50% of the
combined voting power of the Company's then  outstanding  securities,  after the
effective  date of  such  merger,  consolidation,  liquidation,  sale  or  other
disposition,  as the case may be, each holder of an outstanding  Option shall be
entitled,  upon exercise of such Option, to receive, in lieu of shares of Common
Stock,  the  number  and  class or  classes  of  shares  of such  stock or other
securities  or  property  to which  such  holder  would have been  entitled  if,
immediately  prior to such  merger,  consolidation,  liquidation,  sale or other
disposition,  such holder had been the holder of record of a number of shares of
Common  Stock  equal to the  number  of shares as to which  such  Option  may be
exercised.

                  Except as otherwise expressly provided in this Plan, the issue
by the Company of shares of stock of any class, or securities  convertible  into
shares of stock of any class,  for cash or  property,  or for labor or  services
either upon direct sale or upon the  exercise of rights or warrants to subscribe
therefor, or upon conversion of shares or obligations of the Company convertible
into such shares or other  securities,  shall not affect,  and no  adjustment by
reason  thereof  shall be made with respect to, the number or price of shares of
Common Stock then subject to outstanding Options.

                  12.      AMENDMENT OR TERMINATION OF PLAN.

                  The Board of Directors  may modify,  revise or terminate  this
Plan at any time and from time to time;  provided,  however,  that  without  the
further approval of the holders of at least a majority of the outstanding shares
of voting  stock,  or if the  provisions  of the  corporate  charter,  bylaws or
applicable  state law prescribes a greater  degree of  stockholder  approval for
this action, without the degree of stockholder approval thus required, the Board
of  Directors  may  not  (a)  materially   increase  the  benefits  accruing  to
participants  under this Plan; (b)  materially  increase the number of shares of
Common Stock that may be issued under this Plan;  or (c)  materially  modify the
requirements as to eligibility for  participation in this Plan,  unless, in each
such case,  the Board of Directors of the Company shall have obtained an opinion
of legal counsel to the effect that stockholder approval of the amendment is not
required (x) by law, (y) by the rules and regulations of, or any agreement with,
the National Association of Securities Dealers, Inc. or (z) to make available to
the optionee with respect to any Option  granted under this Plan the benefits of
Rule 16b-3 under the  Securities  Exchange Act of 1934 (the "1934 Act"),  or any
similar or successor  rule. In addition,  this Plan may not be amended more than
once every six months with  respect to the plan  provisions  referred to in Rule
16b-3(c)(2)(ii)(A)  under the 1934 Act other than to comport with changes in the
Internal  Revenue  Code of 1986,  as amended,  the  Employee  Retirement  Income
Security Act of 1974, as amended,  or the rules thereunder.  All Options granted
under this Plan shall be  subject to the terms and  provisions  of this Plan and
any amendment,  modification  or revision of this Plan shall be deemed to amend,
modify or revise  all  Options  outstanding  under this Plan at the time of such
amendment, modification or revision. If this Plan is terminated by action of the
Board of Directors, all outstanding Options may be terminated.

                  13.      WRITTEN AGREEMENT.

                  Each Option granted  hereunder  shall be embodied in a written
option agreement,  which shall be subject to the terms and conditions prescribed
above, and shall be signed by the optionee and by the appropriate officer of the
Company  for and in the  name  and on  behalf  of the  Company.  Such an  option
agreement shall contain such other provisions as the Committee in its discretion
shall deem advisable.

                  14.      INDEMNIFICATION OF COMMITTEE AND BOARD OF DIRECTORS.

                  The Company  shall,  to the fullest  extent  permitted by law,
indemnify,  defend and hold harmless any person who at any time is a party or is
threatened to be made a party to any  threatened,  pending or completed  action,
suit or proceeding (whether civil, criminal, administrative or investigative) in
any way relating to or arising out of this Plan or any Option or Options granted
hereunder  by  reason  of the  fact  that  such  person  is or was at any time a
director of the Company or a member of the Committee against  judgments,  fines,
penalties,  settlements  and reasonable  expenses  (including  attorney's  fees)
actually  incurred  by such  person  in  connection  with such  action,  suit or
proceeding.  This right of  indemnification  shall  inure to the  benefit of the
heirs, executors and administrators of each such person and is


                                       A-5

<PAGE>  30


in addition  to all other  rights to which such person may be entitled by virtue
of the bylaws of the Company or as a matter of law, contract or otherwise.

                  15.      Effective Date of Amended and Restated Plan.

                  The  amendment  and  restatement  of this  Plan  shall  become
effective,  subject to stockholder approval, on November 14, 1995. The amendment
and restatement of this Plan, and all Options granted  pursuant to the amendment
and restatement of this Plan prior to stockholder approval, shall be void and of
no further force and effect unless the  amendment and  restatement  of this Plan
shall have been approved by the requisite vote of the  stockholders  entitled to
vote at a meeting of the  stockholders  of the Company  called for such  purpose
prior to July 30, 1996. In the event such stockholder  approval is not obtained,
this Plan shall  continue in existence  with the terms and  conditions in effect
prior to the  effective  date of the  amendment  and  restatement  provided  for
hereby.  No Option shall be granted  pursuant to this Plan on or after September
30, 2003.


                                       A-6







© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission