ARONEX PHARMACEUTICALS INC
DEF 14A, 1996-05-10
PHARMACEUTICAL PREPARATIONS
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                          SCHEDULE 14A INFORMATION

                 Proxy Statement Pursuant to Section 14(a)
                   of the Securities Exchange Act of 1934
                              (Amendment No. )

Filed by the Registrant [X]

Filed by a Party other than the Registrant [    ]

Check the appropriate box:

[  ]   Preliminary Proxy Statement

[  ]   Confidential, for Use of the Commission Only (as permitted by 
       Rule 14a-6(e)(2))

[ X]   Definitive Proxy Statement

[  ]   Definitive Additional Materials

[  ]   Soliciting Material Pursuant to Section 240.14a-11(c) or
       Section 240.14a-12

                       ARONEX PHARMACEUTICALS, INC.
              ________________________________________________
              (NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

  ______________________________________________________________________
  (NAME OF PERSON(S) FILING PROXY STATEMENT IF OTHER THAN THE REGISTRANT)

Payment of Filing Fee (Check the appropriate box):

[  ] $125 per Exchange Act Rules 0-11(c)(1)(ii), 14a-6(i)(1), 14a-6(i)(2)
     or Item 22(a)(2) of Schedule 14A.

[  ] $500 per each party to the controversy pursuant to Exchange Act Rule
     14a-6(i)(3).

[  ] Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

       1)     Title of each class of securities to which transaction applies:

              ----------------------------------------------------------- 

       2)     Aggregate number of securities to which transaction applies:

              -----------------------------------------------------------      

3)   Per unit  price  or other  underlying  value of  transaction  computed
     pursuant to Exchange  Act Rule 0-11 (Set forth the amount on which the
     filing fee is calculated and state how it was determined):

               _____________________________________________________________
                                              
       4)     Proposed maximum aggregate value of transaction:


              ______________________________________________________________

        5)     Total fee paid:


              _______________________________________________________________


[  X] Fee paid previously with preliminary materials.

[   ] Check box if any part of the fee is offset as  provided  by Exchange
      Act Rule  0-11(a)(2)  and identify the filing for which the offsetting
      fee was paid previously.  Identify the previous filing by registration
     statement number, or the Form or Schedule and the date of its filing.

       1)     Amount Previously Paid:

              _______________________________________________________________

       2)     Form, Schedule or Registration Statement No.:


              _______________________________________________________________ 

       3)     Filing Party:

              ______________________________________________________________

       4)     Date Filed:

              _______________________________________________________________

<PAGE>  2 


                         ARONEX PHARMACETICALS, INC.
                         3400 Research Forest Drive
                         The Woodlands, Texas 77381



                                                    May 7, 1996




TO OUR STOCKHOLDERS:

     You are cordially  invited to attend a Special Meeting of Stockholders
of Aronex  Pharmaceuticals,  Inc. to be held on Friday,  May 24,  1996,  at
10:00 a.m.,  local time, at the Company's  offices at 3400 Research  Forest
Drive,  The  Woodlands,  Texas.  A Notice  of the  Special  Meeting,  Proxy
Statement and form of proxy are enclosed with this letter.

     We encourage  you to read the Notice of the Special  Meeting and Proxy
Statement so that you may be informed about the business to come before the
meeting.  Your  participation  in  the  Company's  business  is  important,
regardless  of  the  number  of  shares  that  you  hold.  To  ensure  your
representation  at  the  meeting,  please  promptly  sign  and  return  the
accompanying proxy card in the postage-paid envelope.

        We look forward to seeing you on May 24th.


                                            Sincerely,



                                            James M. Chubb
                                            President


<PAGE>  3 

 

                 NOTICE OF SPECIAL MEETING OF STOCKHOLDERS
                          TO BE HELD MAY 24, 1996

To the Stockholders of Aronex Pharmaceuticals, Inc.:

     A Special  Meeting of Stockholders  (the "Special  Meeting") of Aronex
Pharmaceuticals,  Inc. will be held on Friday, May 24, 1996, at 10:00 a.m.,
local time, at the Company's  offices at 3400  Research  Forest Drive,  The
Woodlands, Texas, for the following purposes:

1.   To approve an  amendment  to the  Company's  Amended and Restated
     Certificate  of  Incorporation  to effect a  one-for-two  reverse
     stock split; and

2.   To act upon such  other  business  as may  properly  come  before  the
     Special Meeting or any adjournment(s) thereof.

     Only  stockholders  of record at the close of  business on May 2, 1996
will be entitled to notice of and to vote at the Special Meeting.

     It is important that your shares be represented at the Special Meeting
regardless of whether you plan to attend. THEREFORE,  PLEASE MARK, SIGN AND
DATE THE ENCLOSED PROXY AND RETURN IT IN THE ACCOMPANYING POSTPAID ENVELOPE
AS PROMPTLY AS  POSSIBLE.  If you are present at the Special  Meeting,  and
wish to do so, you may revoke the proxy and vote in person.

                                          By Order of the Board of Directors,


                                          Terance A. Murnane
                                          Secretary

The Woodlands, Texas
May 7, 1996

                                     3
<PAGE>  4 

 
                        ARONEX PHARMACEUTICALS, INC.
                         3400 Research Forest Drive
                         The Woodlands, Texas 77381

 
                              PROXY STATEMENT
                                    For
                      SPECIAL MEETING OF STOCKHOLDERS


                          To Be Held May 24, 1996



                  SOLICITATION AND REVOCABILITY OF PROXIES

     The  accompanying  Proxy is  solicited  by the Board of  Directors  of
Aronex  Pharmaceuticals,  Inc. (the "Company"),  to be voted at the Special
Meeting of Stockholders  of the Company to be held on Friday,  May 24, 1996
(the  "Special  Meeting"),  at 10:00  a.m.,  local time,  at the  Company's
offices at 3400  Research  Forest  Drive,  The  Woodlands,  Texas,  for the
purposes  set  forth in the  accompanying  Notice  of  Special  Meeting  of
Stockholders,  and  at any  adjournment(s)  of the  Special  Meeting.  When
Proxies in the accompanying  form are properly  executed and received,  the
shares  represented  thereby  will  be  voted  at the  Special  Meeting  in
accordance  with  the  directions  noted  thereon.  If  no  directions  are
indicated,  the shares will be voted in favor of the  proposal set forth in
this Proxy  Statement  and in the  discretion  of the persons  appointed as
proxies in the accompanying  form of Proxy with respect to any other matter
that is properly brought before the Special Meeting.

     Each stockholder of the Company has the unconditional  right to revoke
his  Proxy at any time  prior to its  exercise,  either  in  person  at the
Special Meeting or by written notice to the Company addressed to Secretary,
Aronex  Pharmaceuticals,  Inc., 3400 Research Forest Drive,  The Woodlands,
Texas 77381. No revocation by written notice will be effective  unless such
notice has been  received by the  Secretary of the Company prior to the day
of the  Special  Meeting or by the  inspector  of  election  at the Special
Meeting.

     The  principal  executive  offices of the  Company are located at 3400
Research Forest Drive, The Woodlands, Texas 77381. This Proxy Statement and
the  accompanying  Notice of Special Meeting of Stockholders  and Proxy are
being mailed to the Company's stockholders on or about May 7, 1996.

     In  addition  to the  solicitation  of  proxies  by use of this  Proxy
Statement, directors, officers and employees of the Company may solicit the
return of proxies by mail,  personal  interview,  telephone  or  telegraph.
Officers  and  employees  of  the  Company  will  not  receive   additional
compensation for their  solicitation  efforts,  but they will be reimbursed
for  any  out-of-pocket  expenses  incurred.  Brokerage  houses  and  other
custodians,  nominees and fiduciaries will be requested, in connection with
the stock registered in their names, to forward  solicitation  materials to
the beneficial owners of such stock.

     All costs of preparing, printing, assembling and mailing the Notice of
Special Meeting of Stockholders, this Proxy Statement, the enclosed form of
Proxy  and any  additional  materials,  as well as the  cost of  forwarding
solicitation  materials  to the  beneficial  owners  of stock and all other
costs of solicitation, will be borne by the Company.


                                     1
<PAGE>  5
                          PURPOSES OF THE MEETING

     At the Special Meeting,  the Company's  stockholders  will be asked to
consider and act upon the following matters:

     1.   A  proposal  to  amend  the   Company's   Amended  and   Restated
          Certificate   of   Incorporation   (the   "Amended  and  Restated
          Certificate of  Incorporation")  to effect a one-for-two  reverse
          stock split of the Company's  Common  Stock,  par value $.001 per
          share (the "Reverse Split"); and

     2.   The  transaction  of any and all other business that may properly
          come before the Special Meeting or any adjournment(s) thereof.

                             QUORUM AND VOTING
 
     The close of business on May 2, 1996 has been fixed as the record date
(the "Record Date") for the determination of stockholders  entitled to vote
at the Special  Meeting and any  adjournment(s)  thereof.  As of the Record
Date, the Company had issued and  outstanding  21,919,115  shares of Common
Stock and no shares of the Company's  Preferred  Stock, par value $.001 per
share.

     Each  stockholder  of record of Common  Stock will be  entitled to one
vote  per  share  on each  matter  that is  called  to vote at the  Special
Meeting.

     The presence,  either in person or by proxy,  of holders of a majority
of the  outstanding  shares of Common Stock is  necessary  to  constitute a
quorum at the Special  Meeting.  Assuming  the  presence  of a quorum,  the
affirmative  vote of the holders of at least a majority of the  outstanding
shares  of  Common  Stock is  required  for the  approval  of the  proposal
described in this Proxy Statement.

     All Proxies that are properly completed,  signed and returned prior to
the Special Meeting will be voted.  Any Proxy given by a stockholder may be
revoked at any time before it is  exercised by the  stockholder  (i) filing
with the Secretary of the Company an instrument revoking it, (ii) executing
and returning a proxy  bearing a later date or (iii)  attending the Special
Meeting  and  expressing  a desire to vote his  shares  of Common  Stock in
person.  Votes will be counted by American  Stock Transfer & Trust Company,
the Company's  transfer agent and registrar.  With respect to  abstentions,
the  shares  are  considered   present  at  the  meeting  for  purposes  of
determining  a quorum and voting on a  particular  matter.  With respect to
broker  non-votes,  the shares are  considered  present at the  meeting for
purposes  of  determining  a  quorum  but are not  entitled  to vote on the
particular  matter as to which the broker does not have  voting  authority.
Since  abstentions and broker  non-votes are not affirmative  votes for the
matter, they will have the same effect as votes against the matter.




                                     2

<PAGE>  6

       SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

     The  following  table  presents  certain  information   regarding  the
beneficial  ownership of the Company's Common Stock as of March 31, 1996 by
(i) each person who is known by the Company to own  beneficially  more than
five percent of the outstanding  shares of Common Stock, (ii) each director
of the Company, (iii) the Company's chief executive officer and each of the
other executive officers of the Company with annual  compensation in excess
of $100,000  and (iv) all  directors  and  officers  as a group.  Except as
described  below,  each of the persons  listed in the table has sole voting
and investment power with respect to the shares listed.
<TABLE>
<CAPTION>
                                                    Number of       
                                                     Shares of       Percentage 
Name                                               Common Stock      of Shares
                                                   Beneficially    Beneficially
                                                      Owned           Owned             
<S>                                                    <C>             <C>

Amerindo Investment Advisors, Inc. (1)...............  2,015,000        9.3%
   One Embarcadero Center, Suite 2300
   San Francisco, California 94111

Hillman Medical Venture Partnerships (2).............  1,986,540        9.2%
   824 Market Street, Suite 900
   Wilmington, Delaware 19801

HealthCare Ventures Partnerships (3).................  1,917,103       8.8%
   Twin Towers at Metro Bank
   379 Thornall Street
   Edison, New Jersey 08837

The Allstate Corporation (4).........................  1,533,928       7.1%
   2775 Sanders Road
   Northbrook, Illinois 60062

Martin P. Sutter (5).................................    932,704       4.3%
James M. Chubb (6)...................................    232,381       1.1%
Gabriel Lopez-Berestein (7)(11)......................    222,587       1.0%
George B. Mackaness (11).............................     80,000       *

Ronald J. Brenner (8)(11)............................  2,028,410       9.3%
Geoffrey F. Cox (9)(11)..............................    873,611       4.0%
Gregory F. Zaic (10)(11).............................    701,831       3.2%
John F. Chappell (11)................................     36,809       *

Paul A. Cossum (12)..................................     28,140       *

Gillian Ivers-Read (12)..............................     23,750       *

All directors and officers as a group
   (11 persons) (5)-(12).............................  5,174,195      23.8%

       
*      Less than one percent.
<FN>

     (1)  Consists  of  1,917,500  shares  owned  by  Amerindo   Investment
          Advisors,  Inc.  ("Amerindo"),  77,500  shares  owned by Amerindo
          Advisors (U.K.) Limited  ("Amerindo UK"), and 20,000 shares owned
          by  Amerindo   Investment  Advisors  Inc.  Profit  Sharing  Trust
          ("Plan").  The sole  shareholders  and  directors of Amerindo and
          Amerindo UK are Alberto W. Vilar and Gary A. Tanaka, each of whom
          may by deemed to be the beneficial  owner of the 1,995,000 shares
          owned by Amerindo  and  Amerindo UK. Mr. Vilar is sole trustee of
          the  Plan and may be  deemed  to be the  beneficial  owner of the
          20,000 shares owned by the Plan. Based on Schedule 13G, Amendment
          No. 1, dated  February  15, 1996,  of Amerindo,  Amerindo UK, the
          Plan, Mr. Vilar and Mr. Tanaka.
                                     3
<PAGE>  7

     (2)  Consists of 236,180 shares owned by Hillman Medical Ventures 1989
          L.P.,  738,114 shares owned by Hillman Medical Ventures 1990 L.P.
          and 1,012,246  shares owned by Hillman Medical Ventures 1991 L.P.
          (collectively,  the "Hillman Medical Venture Partnerships").  The
          general partners of the Hillman Medical Venture  Partnerships are
          Cashon  Biomedical  Associates,  L.P. and  Hillman/Dover  Limited
          Partnership.   The  general  partner  of  Hillman/Dover   Limited
          Partnership is a wholly-owned  subsidiary of The Hillman Company,
          a firm engaged in diversified  investments  and  operations.  The
          Hillman Company is controlled by Henry L. Hillman, Elsie Hilliard
          Hillman and C.G.  Grefenstette,  Trustees of the Henry L. Hillman
          Trust,  which Trustees may be deemed the beneficial owners of the
          1,986,540   shares   owned  by  the   Hillman   Medical   Venture
          Partnerships.  Dr.  Brenner,  a director of the  Company,  is the
          managing partner of Cashon Biomedical Associates,  L.P., of which
          the other general partners are Hal S. Broderson, M.D. and Charles
          G. Hadley.  Dr.  Brenner,  Dr.  Broderson  and Mr.  Hadley may be
          deemed to beneficially own such shares.
     (3)  Consists of 489,246 shares owned by HealthCare  Venture  Partners
          L.P.,  382,356  shares owned by  HealthCare  Venture  Partners II
          L.P.,  808,199  shares owned by HealthCare  Venture  Partners III
          L.P. and 237,302 shares owned by HealthCare  Venture  Partners IV
          L.P. (collectively, the "HealthCare Venture Partnerships"). James
          H.  Cavanaugh,  Harold R.  Werner,  John W.  Littlechild,  Ronald
          Shipman  and William  Crouse are general  partners of each of the
          HealthCare Venture Partnerships and may be deemed to beneficially
          own such shares.
     (4)  Consists of 1,533,928 shares owned by Allstate Insurance Company,
          a wholly owned subsidiary of The Allstate  Corporation,  based on
          Schedule  13G,  Amendment  No. 3, dated  February 9, 1996, of The
          Allstate Corporation.
     (5)  Includes  893,704  shares owned by The  Woodlands  Venture  Fund,
          L.P., and 1,000 shares owned by The Woodlands  Venture  Partners,
          L.P. Mr.  Sutter is a general  partner of The  Woodlands  Venture
          Partners,  L.P.,  which is the general  partner of The  Woodlands
          Venture Fund, L.P. Mr. Sutter disclaims  beneficial  ownership of
          the 893,704 shares owned by The Woodlands Venture Fund, L.P. Also
          includes  37,000  shares which may be acquired on the exercise of
          the currently vested portion of stock options.
     (6)  Includes  91,031  shares that may be acquired on the  exercise of
          stock options.
     (7)  Includes  91,364  shares that may be acquired on the  exercise of
          stock options. Includes 55,000 shares that may be acquired on the
          exercise of stock options granted subject to stockholder approval
          prior to issuance.  The Company  intends to seek such approval at
          its 1996 annual meeting of  stockholders.  Excludes 39,394 shares
          held by a  relative  of  Dr. Lopez-Berestein,  but as to which he
          disclaims beneficial ownership.
     (8)  Includes  1,986,540  shares owned by the Hillman  Medical Venture
          Partnerships, of which Dr. Brenner is the managing partner of one
          of the general partners.
     (9)  Includes 846,611 shares owned by Genzyme Corporation.  Dr. Cox is
          Senior Vice  President of Genzyme.  Dr. Cox disclaims  beneficial
          ownership of the shares held by Genzyme.
     (10) Includes  674,831  shares owned by Prince  Venture  Partners III,
          L.P.  Mr.  Zaic is a general  partner of Prince  Ventures,  L.P.,
          which is a general  partner of Prince Venture  Partners III, L.P.
          Mr. Zaic  disclaims  beneficial  ownership  of the shares held by
          Prince Venture Partners III, L.P.
     (11) Includes  25,000  shares that may be acquired on the  exercise of
          stock options  granted  subject to stockholder  approval prior to
          issuance.  The Company  intends to seek such approval at its 1996
          annual meeting of stockholders.
     (12) Represents  shares that may be acquired on the  exercise of stock
          options.
</FN>
</TABLE>

     The  holders of an  aggregate  of  approximately  9,669,616  shares of
Common Stock are parties to a Stockholders  Agreement.  Those  stockholders
include the Hillman Medical Venture  Partnerships,  the HealthCare Ventures
Partnerships,  The Woodlands  Venture  Fund,  L.P.,  The Woodlands  Venture
Partners, L.P., Genzyme Corporation,  Prince Venture Partners III, L.P. and
Gabriel  Lopez-Berestein.  The Stockholders  Agreement  continues in effect
until the later of (i) the  completion  of the  second  annual  meeting  of
stockholders of the Company after September 11, 1995 and (ii) September 11,
1997.



                                     4
<PAGE>  8
                               REVERSE SPLIT

GENERAL

     At the Special Meeting,  the stockholders of the Company will consider
and vote upon a proposal  providing for a one-for-two  Reverse Split of the
Common  Stock.  The Reverse  Split will be effected by an  amendment to the
Company's Amended and Restated  Certificate of Incorporation  (the "Reverse
Split  Amendment")  that is contained in Exhibit A to this Proxy Statement,
which is incorporated by reference herein. The Reverse Split Amendment will
become  effective  upon its filing with the Secretary of State of the State
of Delaware (the "Effective Date").  Fractional shares of Common Stock will
not be issued as a result of the Reverse  Split.  Stockholders  entitled to
receive a fractional  share of Common Stock as a consequence of the Reverse
Split will,  instead,  receive  from the  Company a cash  payment in United
States  dollars equal to such fraction  multiplied by two times the average
closing  price of the Common  Stock on the Nasdaq  National  Market for the
five trading days immediately preceding the Effective Date.

AMENDMENT TO THE AMENDED AND RESTATED CERTIFICATE OF INCORPORATION

     The Reverse Split  Amendment  will amend Article IV of the Amended and
Restated  Certificate  of  Incorporation  to add a new  Section  D.  At the
Effective  Date,  without  further action on the part of the Company or the
stockholders, each share of Common Stock will be converted into one-half of
a share of Common Stock.  The Reverse Split Amendment will become effective
upon its filing with the Secretary of State of the State of Delaware.

     A vote for the Reverse Split  proposal will include  authorization  of
the Company's Board of Directors not to file the Reverse Split Amendment in
the event the Board of Directors  determines  that filing the Reverse Split
Amendment would not be in the best interest of the Company's  stockholders.
Factors leading to such determination  could include,  without  limitation,
abandonment of the proposed  Offering  discussed  below under "--Reasons for
the Reverse Split."

VOTE NEEDED FOR APPROVAL

     The proposed Reverse Split and the related  amendment to the Company's
Amended and Restated  Certificate of Incorporation  must be approved by the
holders of at least a majority of the outstanding shares of Common Stock.
    
     THE BOARD OF DIRECTORS HAS  UNANIMOUSLY  ADOPTED A RESOLUTION  SETTING
FORTH THE PROPOSED REVERSE SPLIT AMENDMENT,  AND HEREBY RECOMMENDS THAT THE
STOCKHOLDERS OF THE COMPANY VOTE FOR THE PROPOSED AMENDMENT.
                                 ---

EFFECT OF THE PROPOSED REVERSE SPLIT

     The proposed  Reverse  Split will be effected by means of an amendment
to the Amended and Restated  Certificate of  Incorporation.  Under Delaware
law, no appraisal  rights are  available to dissenting  stockholders.  Each
stockholder  who owns fewer  than two shares of Common  Stock will have his
fractional  share of Common Stock  converted into the right to receive cash
as set forth  below in  "--Exchange  of Stock  Certificates  and Payment for
Fractional  Shares." The interest of such  stockholder  in the Company will
thereby be terminated,  and such stockholder will have no right to share in
the assets or future growth of the Company.  Each  stockholder who owns two
or more shares of Common Stock will  continue to own shares of Common Stock
and will  share in the  assets  and  future  growth  of the  Company.  Such
interest will be represented by one-half as many shares as such stockholder
owned before the Reverse  Split,  except that no fractional  shares will be
issued.

     The  following  schedule  of  stockholders'  equity  sets  forth as of
December 31, 1995, on a pro forma basis,  the effect of the adoption of the
Reverse Split proposal.  Adoption of the Reverse Split proposal will result
in a one-for-two reverse split of the Common Stock.

                                     5

<PAGE>  9
                 PRO FORMA SCHEDULE OF STOCKHOLDERS' EQUITY
                ASSUMING ADOPTION OF REVERSE SPLIT PROPOSAL
                                (UNAUDITED)
                       (IN THOUSANDS, EXCEPT SHARES)

 
<TABLE>
<CAPTION>
                                                                      Pro     Adjusted 
                                                      Historical     Forma     Balance
                                                      December 31,   Adjust-  December 31, 
                                                          1995       ments(1)    1995
                                                                                     
<S>                                                   <C>           <C>       <C>

Stockholders' equity:
 Preferred stock $.001 par value, 10,000,000 shares
  authorized, none issued and outstanding........    $      -       $     -   $     -
Common stock $.001 par value, 75,000,000 shares
  authorized, 20,760,112 shares issued and
  outstanding pre-split; 10,380,056 shares issued
  and outstanding post-split.......................        21           (10)         11
Additional paid-in capital.........................    56,331            10      56,341
Common stock warrants..............................     1,488            -        1,488
Treasury stock.....................................       (11)           -          (11)
Deferred compensation..............................    (1,536)           -       (1,536)
Unrealized loss on available-for-sale securities...      (116)           -         (116)
Deficit accumulated during development stage.......   (44,183)           -      (44,183)
                                                       ----------     --------  ---------
  Total stockholders' equity....................... $  11,994       $     -   $  11,994
                                                       ==========     ========   =========
 <FN>

- ---------
     (1)  Represents  the proposed  one-for-two  Common Stock reverse stock
          split which results in a net  reduction of  10,380,056  shares of
          Common  Stock  outstanding  assuming  no  fractional  shares  are
          purchased.
</FN>

</TABLE>
     Adoption of the Reverse Split proposal as of January 1, 1995 would not
have had an effect on net  income for the fiscal  year ended  December  31,
1995. However, net loss per share would have been proportionately increased
from $(1.34) to $(2.68).  No adjustment  has been made for the reduction in
the number of shares of Common Stock resulting from the payment of cash for
fractional  shares.  The  Company  does not  believe  that  adoption of the
Reverse Split will adversely affect the continued  listing of the Company's
Common Stock on the Nasdaq National Market.

REASONS FOR THE REVERSE SPLIT

     Management of the Company  believes  that it may be more  difficult to
attract new  investors to the Company  because the Common Stock trades at a
relatively  low price  (the  closing  price on May 2, 1996 was  $6.125  per
share).  Institutional  investors  typically  are  unwilling  to  invest in
companies  whose stock  trades at less than $5, or, in some cases,  $10 per
share.  Stockbrokers also are sometimes subject to internal restrictions on
their ability to recommend stocks trading at less than $5 per share because
of the general  presumption that such stock may be highly  speculative.  In
addition,  stock which trades in the trading range of the Company's  Common
Stock  may  not  be  marginable   under  the  internal   policies  of  some
stockbrokers.

     In addition,  the Company has filed a  registration  statement on Form
S-3  related to a proposed  public  offering  by the  Company of  6,000,000
shares of Common Stock (the  "Offering").  The underwriters  engaged by the
Company in connection  with the Offering have advised the Company that they
believe the  marketability of the Common Stock for purposes of the Offering
would be enhanced by the Reverse Split.

     It is  anticipated  that  following  the  consummation  of the Reverse
Split,  the shares of Common  Stock will trade at a price per share that is
significantly higher than the current market price.  However,  there can be
no assurance that,  after the consummation of the Reverse Split, the shares
of Common  Stock  will  trade at two times the  market  price of the Common
Stock prior to the Reverse Split.
                                     6

<PAGE> 10

EXCHANGE OF STOCK CERTIFICATES AND PAYMENT FOR FRACTIONAL SHARES

     The  exchange  of shares of Common  Stock will occur on the  Effective
Date  without  any action on the part of  stockholders  of the  Company and
without regard to the date  certificates  representing  pre-split shares of
Common  Stock are  physically  surrendered  for  certificates  representing
post-split  shares of Common  Stock.  The  Company's  Transfer  Agent  will
exchange certificates. In the event that the number of shares of post-split
Common Stock includes a fraction,  the Company will pay to the stockholder,
in lieu of the issuance of fractional shares of the Company,  a cash amount
in  United  States  dollars  which  will  be  equal  to the  same  fraction
multiplied  by two times the average  closing  price of the Common Stock on
the Nasdaq National Market for the five trading days immediately  preceding
the  Effective  Date.  The closing  price of the Common  Stock  ranged from
$5.375 to $6.50 from April 26 to May 2, 1996, with an average closing price
of $6.00. A change in the closing price of the Common Stock will affect the
amount received for a fractional share by a stockholder.

     As soon as practicable  after the Effective  Date,  transmittal  forms
will be mailed to each  holder of  record  of  certificates  for  shares of
Common Stock to be used in forwarding their  certificates for surrender and
exchange for  certificates  representing the number of shares of post-split
Common Stock such  stockholders are entitled to receive as a consequence of
the Reverse  Split.  After receipt of such  transmittal  form,  each holder
should surrender the certificates  representing  pre-split shares of Common
Stock of the Company. Each holder who surrenders  certificates will receive
new  certificates  representing  the whole  number of shares of  post-split
Common  Stock to which he is  entitled  and any cash  payable  in lieu of a
fractional share. The transmittal forms will be accompanied by instructions
specifying  other  details of the  exchange.  STOCKHOLDERS  SHOULD NOT SEND
THEIR CERTIFICATES UNTIL THEY RECEIVE A TRANSMITTAL FORM.

     After the Effective  Date,  each  certificate  representing  pre-split
shares of Common Stock will,  until  surrendered and exchanged as described
above, be deemed, for all corporate purposes,  to evidence ownership of the
whole number of post-split shares of Common Stock, and the right to receive
from the Company the amount of cash for any fractional  shares,  into which
the shares evidenced by such  certificate have been converted,  except that
the holder of such unexchanged certificates will not be entitled to receive
any  dividends  or other  distributions  payable by the  Company  after the
Effective Date,  until the  certificates  representing  pre-split shares of
Common Stock have been surrendered.  Such dividends and  distributions,  if
any,  will  be  accumulated,  and  at the  time  of  the  surrender  of the
certificates  for pre-split  shares  of  Common  Stock,  all such  unpaid
dividends or distributions will be paid without interest.

FEDERAL INCOME TAX CONSEQUENCES

     The  following   discussion   describes  certain  federal  income  tax
consequences  of the  Reverse  Split.  This  discussion  is based  upon the
Internal  Revenue  Code  of  1986  (the  "Code"),   existing  and  proposed
regulations  thereunder,  reports  of  congressional  committees,  judicial
decisions and current administrative rulings and practices,  all as amended
and in  effect  on the  date  hereof.  Any of  these  authorities  could be
repealed,  overruled  or  modified at any time.  Any such  change  could be
retroactive  and,  accordingly,  could cause the tax  consequences  to vary
substantially  from the  consequences  described  below. No ruling from the
Internal Revenue Service (the "IRS") with respect to the matters  discussed
herein has been  requested,  and there is no  assurance  that the IRS would
agree with the conclusions set forth in this discussion.

     This discussion is for general  information  only and does not address
the federal  income tax  consequences  that may be  relevant to  particular
stockholders in light of their personal  circumstances  or to certain types
of  stockholders  (such as  dealers  in  securities,  insurance  companies,
foreign  individuals and entities,  financial  institutions  and tax-exempt
entities) who may be subject to special  treatment under the federal income
tax laws. This discussion also does not address any tax consequences  under
state, local or foreign laws.

     STOCKHOLDERS  ARE  URGED  TO  CONSULT  THEIR  TAX  ADVISORS  AS TO THE
PARTICULAR TAX  CONSEQUENCES TO THEM OF PARTICIPATION IN THE REVERSE SPLIT,
INCLUDING THE

                                     7
<PAGE>  11

APPLICABILITY  OF  ANY  STATE,  LOCAL  OR  FOREIGN  TAX  LAWS,  CHANGES  IN
APPLICABLE TAX LAWS AND ANY PENDING OR PROPOSED LEGISLATION.

     The Company  should not  recognize any gain or loss as a result of the
Reverse  Split.  No gain or loss should be recognized by a stockholder  who
receives only Common Stock upon the Reverse Split.  The aggregate tax basis
of post-split  Common Stock  received by such a  stockholder  in connection
with the Reverse Split will equal the stockholder's  aggregate tax basis in
the  pre-split  Common  Stock  exchanged  therefor  and  generally  will be
allocated  among  post-split  Common  Stock  received  on a pro rata basis.
Stockholders who have used the specific  identification  method to identify
their basis in pre-split  Common  Stock  surrendered  in the Reverse  Split
should  consult  their own tax  advisors  to  determine  their basis in the
post-split  Common Stock received in exchange  therefor.  A stockholder who
receives cash in lieu of a fractional  share of Common Stock that otherwise
would be held as a capital asset generally should recognize capital gain or
loss on the  receipt  of such  cash in an  amount  equal to the  difference
between the cash received and his basis in such fractional  share of Common
Stock. For this purpose, a stockholder's  basis in such fractional share of
Common Stock will be determined  as if the  stockholder  actually  received
such fractional share.

                             OTHER INFORMATION

ADDITIONAL MATTERS

     While the notice for the Special  Meeting calls for the transaction of
any other business as may be properly presented, management is not aware of
any business to be submitted at the Special Meeting not referred to in this
Proxy Statement. If any further business is presented, the persons named in
the  Proxy  will act  according  to their  best  judgment  on behalf of the
stockholders they represent.

SUBMISSION OF STOCKHOLDER PROPOSALS

     Any  stockholder  who wishes to  present a proposal  for action at the
1996 Annual Meeting of Stockholders  and who wishes to have it set forth in
the  proxy  statement  and  identified  in the  form of proxy  prepared  by
management must have notified management of the Company in such a manner so
that such notice was  received by  management  by February 1, 1996,  and in
such form as required  under the rules and  regulations  promulgated by the
Securities and Exchange Commission.

                                          By Order of the Board of Directors



                                          Terance A. Murnane
                                          Secretary


May 7, 1996
The Woodlands, Texas

                                     8
<PAGE>  12
                                                         EXHIBIT A


                          CERTIFICATE OF AMENDMENT
                                     OF
             AMENDED AND RESTATED CERTIFICATE OF INCORPORATION
                                     OF
                        ARONEX PHARMACEUTICALS, INC.


     Aronex  Pharmaceuticals,  Inc.  (the  "Corporation"),   organized  and
existing under and by virtue of the General Corporation Law of the State of
Delaware (the "DGCL") does hereby certify:

     FIRST:  That the Board of  Directors of the  Corporation  duly adopted
resolutions  setting  forth the  following  amendment  to the  Amended  and
Restated Certificate of Incorporation of the Corporation (the "Amendment"),
declaring the  Amendment to be advisable and calling for the  submission of
the  proposed   Amendment  to  the  stockholders  of  the  Corporation  for
consideration  thereof. The resolution setting forth the proposed Amendment
is as follows:

     ARTICLE IV of the Amended and Restated Certificate of Incorporation of
Aronex Pharmaceuticals,  Inc., a Delaware corporation, is hereby amended by
adding thereto new Section D to read as follows:

     D.       Reverse Split

     (i)  Effective  immediately  upon the filing of this  Amendment to the
Amended and  Restated  Certificate  of  Incorporation  in the office of the
Secretary  of State of the State of  Delaware,  each  outstanding  share of
previously  existing Common Stock shall be and hereby is converted into and
reclassified  as one-half of a share of Common  Stock;  provided,  however,
that  fractional  shares of Common Stock will not be issued and each holder
of a fractional  share of Common Stock shall receive in lieu thereof a cash
payment from the  Corporation  determined by  multiplying  such  fractional
share of Common Stock by two times the average  closing price of a share of
previously existing Common Stock on the Nasdaq National Market for the five
trading days immediately  preceding the effective date, and upon such other
terms as the officers of the Corporation, in their sole discretion, deem to
be advisable and in the best interests of the Corporation.

     (ii) Certificates representing reclassified shares are hereby canceled
and upon presentation of the canceled certificates to the Corporation,  the
holders  thereof shall be entitled to receive  certificate(s)  representing
the new shares into which such canceled shares have been converted.

     SECOND:  That  thereafter  pursuant  to a  resolution  of the Board of
Directors,  a special  meeting of the  stockholders  of the Corporation was
duly called and held,  upon notice in  accordance  with  Section 222 of the
DGCL at which meeting the necessary number of shares as required by statute
were voted in favor of the Amendment.

     THIRD:  That the  Amendment  was duly adopted in  accordance  with the
provisions of Section 242 of the DGCL.

     FOURTH:  That the  Amendment  shall  be  effective  on the  date  this
Certificate of Amendment is filed and accepted by the Secretary of State of
the State of Delaware.


                                    A-1
<PAGE>  13

     IN WITNESS WHEREOF,  the Corporation has caused this certificate to be
signed by James M.  Chubb,  its  President,  and  attested  by  Terance  A.
Murnane, its Secretary, this 24th day of May, 1996.


                                    ARONEX PHARMACEUTICALS, INC.


                                    By:    -----------------------------
                                           James M. Chubb  
                                           President


ATTEST:           ----------------------------------
                  Terance A. Murnane
                  Secretary

                                    A-2
<PAGE>  14

   P                                           ARONEX PHARMACEUTICALS, INC.
   R
   O                                            3400 Research Forest Drive
   X                                            The Woodlands, Texas 77381
   Y

        THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

     THE UNDERSIGNED HEREBY APPOINTS JAMES M. CHUBB AND TERANCE A. MURNANE,
AND  EACH OF  THEM,  AS  PROXIES,  EACH  WITH  THE  POWER  TO  APPOINT  HIS
SUBSTITUTE, AND HEREBY AUTHORIZES THEM TO REPRESENT AND VOTE, AS DESIGNATED
ON THE REVERSE SIDE, ALL OF THE SHARES OF THE COMMON STOCK, PAR VALUE $.001
PER SHARE, OF ARONEX PHARMACEUTICALS,  INC. (THE "COMPANY"), HELD OF RECORD
BY THE  UNDERSIGNED  ON MAY 2, 1996,  AT THE SPECIAL  MEETING (THE "SPECIAL
MEETING") OF  STOCKHOLDERS  OF THE COMPANY TO BE HELD ON MAY 24, 1996,  AND
ANY ADJOURNMENT(S) THEREOF.
 
                                                               --------------
                                                                SEE REVERSE
            (TO BE DATED AND SIGNED ON REVERSE SIDE)                 SIDE
                                                               --------------

         





|X|    PLEASE MARK VOTES
       AS IN THIS EXAMPLE.



THIS PROXY,  WHEN PROPERLY  EXECUTED AND DATED, WILL BE VOTED IN THE MANNER
DIRECTED HEREIN BY THE UNDERSIGNED STOCKHOLDER(S). IF NO DIRECTION IS MADE,
THIS PROXY WILL BE VOTED FOR  PROPOSAL  1, AND THE  PROXIES  WILL USE THEIR
DISCRETION WITH RESPECT TO ANY MATTERS REFERRED TO IN PROPOSAL 2.


                                            
     1.   PROPOSAL    TO    APPROVE   AN    
          AMENDMENT  TO  THE   COMPANY'S
          AMENDED      AND      RESTATED
          CERTIFICATE  OF  INCORPORATION
          TO   EFFECT   A    ONE-FOR-TWO
          REVERSE  STOCK  SPLIT  OF  THE
          COMPANY'S  COMMON  STOCK,  PAR
          VALUE  $.001  PER  SHARE,   AS        FOR  AGAINST   ABSTAIN
          DESCRIBED  IN  THE   COMPANY'S
          PROXY  STATEMENT  RELATING  TO        /  /   /  /      /  /
          THE SPECIAL MEETING.


     2.   IN   THEIR   DISCRETION,   THE
          PROXIES ARE AUTHORIZED TO VOTE
          UPON SUCH  OTHER  BUSINESS  AS
          MAY  PROPERLY  COME BEFORE THE       /  /   /  /      /  /      
          SPECIAL    MEETING   AND   ANY
          ADJOURNMENT(S) THEREOF.


                                                   MARK HERE FOR
                                                   ADDRESS CHANGE      /  /
                                                   AND NOTE AT LEFT



 Please execute this Proxy as your name appears hereon. When shares
 are held by joint tenants, both should sign. When signing as attorney,
 executor, administrator, trustee or guardian, please give full title as
 such. If a corporation, please sign in full corporate name by the
 president or other authorized officer. If a partnership, please sign in
 partnership name by authorized person.


PLEASE MARK, SIGN,
DATE AND RETURN THIS
PROXY PROMPTLY USING      Signature:                          Date           
THE ENCLOSED ENVELOPE.
                    
                          Signature:                          Date           

                                    A-3



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