ARONEX PHARMACEUTICALS INC
SC 13G/A, 1997-02-13
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G/A 

                   Under the Securities Exchange Act of 1934
                              (Amendment No.  2 )

                           ARONEX PHARMACEUTICALS INC.
                    ---------------------------------------
                                (Name of Issuer)

                                  COMMON STOCK
                    ---------------------------------------
                         (Title of Class of Securities)

                                    042666107
                               ------------------
                                 (CUSIP Number)


Check the following box if a fee is being paid with this statement [ ].  (A fee
is not required only if the filing person:  (1) has a previous statement on
file reporting beneficial ownership of more than five percent of the class of
securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of such class.)
(See Rule 13d-7.)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).


                       (Continued on following pages(s))
<PAGE>
                                  SCHEDULE 13G/A 
CUSIP NO. 042666107
- --------------------------------------------------------------------------------

1)   Name of Reporting Person           
     S.S. or I.R.S Identification

     AMERINDO INVESTMENT ADVISORS INC., a California corporation, AMERINDO 
     INVESTMENT ADVISORS, INC., a Panama corporation, the AMERINDO INVESTMENT
     ADVISORS INC. PROFIT SHARING TRUST, ALBERTO W. VILAR and GARY A. TANAKA, 
     who disaffirm the existence of any group and who are sometimes 
     collectively referred to as the "Reporting Persons."

- --------------------------------------------------------------------------------

2)   Check the Appropriate Box                    (a)
     if a Member of a Group                       ----------------------------
     (See Instructions)                           (b)
                                                  ----------------------------

- --------------------------------------------------------------------------------

3)   SEC Use Only

- --------------------------------------------------------------------------------

4)   Citizenship or Place of Organization                  

     See Item 4 of separate cover pages for Reporting Persons

- --------------------------------------------------------------------------------

Number of Shares    (5)  Sole Voting Power                          
Beneficially Owned  
by Each Reporting   10,000 shares in the aggregate for all Reporting Persons and
Person with         as to all but a portion of which beneficial ownership is
                    disclaimed  

                    (6)  Shared Voting Power
   
                    1,031,250 shares in the aggregate for all Reporting Persons
                    and as to all of which beneficial ownership is disclaimed

                    (7)  Sole Dispositive Power                     

                    10,000 shares in the aggregate for all Reporting Persons and
                    as to all but a portion of which beneficial ownership is 
                    disclaimed

                    (8)  Shared Dispositive Power                    

                    1,031,250 shares in the aggregate for all Reporting Persons
                    and as to all of which beneficial ownership is disclaimed

- -------------------------------------------------------------------------------

9)   Aggregate Amount Beneficially
     Owned by Each Reporting Person

     1,041,250 shares in the aggregate for all Reporting Persons and as to
     all but up to 10,000 of which beneficial ownership is disclaimed

- --------------------------------------------------------------------------------

10)  Check if the Aggregate Amount                                          [X]
     in Row 9 Excludes Certain
     Shares (See Instructions)

- --------------------------------------------------------------------------------

11)  Percent of Class Represented
     by Amount in Row 9                                                    7.15%

- --------------------------------------------------------------------------------

12)  Type of Reporting Person                                        IA, EP, IN
     (See Instructions)

- --------------------------------------------------------------------------------
<PAGE>

                                  SCHEDULE 13G/A 

CUSIP NO.   042666107

- --------------------------------------------------------------------------------

1)   Name of Reporting Person           
     S.S. or I.R.S Identification

     AMERINDO INVESTMENT ADVISORS INC.

- --------------------------------------------------------------------------------

2)   Check the Appropriate Box                    (a)
     if a Member of a Group                       ----------------------------
     (See Instructions)                           (b)
                                                  ----------------------------

- --------------------------------------------------------------------------------

3)   SEC Use Only

- --------------------------------------------------------------------------------

4)   Citizenship or Place of Organization                  

     California
- --------------------------------------------------------------------------------

Number of Shares    (5)  Sole Voting Power                           None
Beneficially Owned  
by Each Reporting   (6)  Shared Voting Power                         
Person with         
                    1,010,000 shares, as to all of which beneficial ownership 
                    is disclaimed

                    (7)  Sole Dispositive Power                      None

                    (8)  Shared Dispositive Power                    

                    1,010,000 shares, as to all of which beneficial ownership
                    is disclaimed

- -------------------------------------------------------------------------------

9)   Aggregate Amount Beneficially
     Owned by Each Reporting Person                                  

     1,010,000 shares, as to all of which beneficial ownership is disclaimed

- --------------------------------------------------------------------------------

10)  Check if the Aggregate Amount                                          [X]
     in Row 9 Excludes Certain
     Shares (See Instructions)

- --------------------------------------------------------------------------------

11)  Percent of Class Represented
     by Amount in Row 9                                                    6.94%

- --------------------------------------------------------------------------------

12)  Type of Reporting Person                                                IA
     (See Instructions)

- --------------------------------------------------------------------------------
<PAGE>


                                  SCHEDULE 13G/A 

CUSIP NO.   042666107

- --------------------------------------------------------------------------------

1)   Name of Reporting Person        
     S.S. or I.R.S Identification

     AMERINDO INVESTMENT ADVISORS, INC.

- --------------------------------------------------------------------------------

2)   Check the Appropriate Box                    (a)
     if a Member of a Group                       ----------------------------
     (See Instructions)                           (b)
                                                  ----------------------------

- --------------------------------------------------------------------------------

3)   SEC Use Only

- --------------------------------------------------------------------------------

4)   Citizenship or Place of Organization                  

     Panama
- --------------------------------------------------------------------------------

Number of Shares    (5)  Sole Voting Power                           None
Beneficially Owned  
by Each Reporting   (6)  Shared Voting Power                         
Person with
                    21,250 shares, as to all of which beneficial ownership is
                    disclaimed
                             
                    (7)  Sole Dispositive Power                      None

                    (8)  Shared Dispositive Power                    
                    
                    21,250 shares, as to all of which beneficial ownership is
                    disclaimed

- -------------------------------------------------------------------------------

9)   Aggregate Amount Beneficially
     Owned by Each Reporting Person                                  

     21,250 shares, as to all of which beneficial ownership is disclaimed

- --------------------------------------------------------------------------------

10)  Check if the Aggregate Amount                                          [X]
     in Row 9 Excludes Certain
     Shares (See Instructions)

- --------------------------------------------------------------------------------

11)  Percent of Class Represented
     by Amount in Row 9                                                   0.14%

- --------------------------------------------------------------------------------

12)  Type of Reporting Person                                                IA
     (See Instructions)

- --------------------------------------------------------------------------------
<PAGE>


                                  SCHEDULE 13G/A 

CUSIP NO.   042666107

- --------------------------------------------------------------------------------

1)   Name of Reporting Person        
     S.S. or I.R.S Identification

     AMERINDO INVESTMENT ADVISORS INC. PROFIT SHARING TRUST

- --------------------------------------------------------------------------------

2)   Check the Appropriate Box                    (a)
     if a Member of a Group                       ----------------------------
     (See Instructions)                           (b)
                                                  ----------------------------

- --------------------------------------------------------------------------------

3)   SEC Use Only

- --------------------------------------------------------------------------------

4)   Citizenship or Place of Organization                  

     Florida
- --------------------------------------------------------------------------------

Number of Shares    (5)  Sole Voting Power                           
Beneficially Owned
by Each Reporting   10,000 shares, as to all of which beneficial ownership is
Person with         disclaimed

                    (6)  Shared Voting Power                        None
                             
                    (7)  Sole Dispositive Power                      

                    10,000 shares, as to all of which beneficial ownership is
                    disclaimed

                    (8)  Shared Dispositive Power                    None

- -------------------------------------------------------------------------------

9)   Aggregate Amount Beneficially
     Owned by Each Reporting Person                                  

     10,000 shares, as to all of which beneficial ownership is disclaimed

- --------------------------------------------------------------------------------

10)  Check if the Aggregate Amount                                          [X]
     in Row 9 Excludes Certain
     Shares (See Instructions)

- --------------------------------------------------------------------------------

11)  Percent of Class Represented
     by Amount in Row 9                                                   0.07%

- --------------------------------------------------------------------------------

12)  Type of Reporting Person                                                EP
     (See Instructions)

- --------------------------------------------------------------------------------



<PAGE>


                                  SCHEDULE 13G/A 

CUSIP NO.   042666107

- --------------------------------------------------------------------------------

1)   Name of Reporting Person        
     S.S. or I.R.S Identification

     ALBERTO W. VILAR

- --------------------------------------------------------------------------------

2)   Check the Appropriate Box                    (a)
     if a Member of a Group                       ----------------------------
     (See Instructions)                           (b)
                                                  ----------------------------

- --------------------------------------------------------------------------------

3)   SEC Use Only

- --------------------------------------------------------------------------------

4)   Citizenship or Place of Organization                  

     United States
- --------------------------------------------------------------------------------

Number of Shares    
Beneficially Owned  (5)  Sole Voting Power                            
by Each Reporting
Person with         10,000 shares, as to only a portion of which beneficial
                    ownership is affirmed

                    (6)  Shared Voting Power

                    1,031,250 shares, as to all of which beneficial ownership
                    is disclaimed

                    (7)  Sole Dispositive Power                       

                    10,000 shares, as to only a portion of which beneficial
                    ownership is affirmed

                    (8)  Shared Dispositive Power                    

                    1,031,250 shares, as to all of which beneficial ownership 
                    is disclaimed

- -------------------------------------------------------------------------------

9)   Aggregate Amount Beneficially
     Owned by Each Reporting Person                                  

     1,041,250 shares, as to all but a portion of which beneficial ownership 
     is disclaimed

- --------------------------------------------------------------------------------

10)  Check if the Aggregate Amount                                          [X]
     in Row 9 Excludes Certain
     Shares (See Instructions)

- --------------------------------------------------------------------------------

11)  Percent of Class Represented
     by Amount in Row 9                                                    7.15%

- --------------------------------------------------------------------------------

12)  Type of Reporting Person                                                IN
     (See Instructions)

- --------------------------------------------------------------------------------
<PAGE>

                                  SCHEDULE 13G/A

CUSIP NO.   042666107

- --------------------------------------------------------------------------------

1)   Name of Reporting Person        
     S.S. or I.R.S Identification

     GARY A. TANAKA

- --------------------------------------------------------------------------------

2)   Check the Appropriate Box                    (a)
     if a Member of a Group                       ----------------------------
     (See Instructions)                           (b)
                                                  ----------------------------

- --------------------------------------------------------------------------------

3)   SEC Use Only

- --------------------------------------------------------------------------------

4)   Citizenship or Place of Organization                  

     United States
- --------------------------------------------------------------------------------

Number of Shares    (5)  Sole Voting Power                           None
Beneficially Owned  
by Each Reporting   (6)  Shared Voting Power                         
Person with         
                    1,031,250 shares, as to all of which beneficial ownership 
                    is disclaimed

                    (7)  Sole Dispositive Power                      None

                    (8)  Shared Dispositive Power                    

                    1,031,250 shares, as to all of which beneficial ownership 
                    is disclaimed

- -------------------------------------------------------------------------------

9)   Aggregate Amount Beneficially
     Owned by Each Reporting Person                                  

     1,031,250 shares, as to all of which beneficial ownership is disclaimed

- --------------------------------------------------------------------------------

10)  Check if the Aggregate Amount                                          [X]
     in Row 9 Excludes Certain
     Shares (See Instructions)

- --------------------------------------------------------------------------------

11)  Percent of Class Represented
     by Amount in Row 9                                                    7.08%

- --------------------------------------------------------------------------------

12)  Type of Reporting Person                                                IN
     (See Instructions)

- --------------------------------------------------------------------------------
<PAGE>





Item 1.
- ------

     (a) The name of issuer as to whose securities this statement relates is
Aronex Pharmaceuticals Inc. (the "Issuer").

     (b) The address of Issuer's principal place of business is 3400 Research
Forest Drive, The Woodlands, TX 77381.


Item 2.
- -------

     (a-c) This statement is being filed by Amerindo Investment Advisors Inc., a
California corporation whose principal executive offices are located at One
Embarcadero Center, Suite 2300, San Francisco, California, 94111 ("Amerindo"),
Amerindo Investment Advisors, Inc., a Panama corporation, whose principal 
executive offices are located at Edificio Sucre, Calle 48 Este, Bella Vista, 
Apartado 6277, Panama 5, Panama ("Amerindo Panama"), the Amerindo Investment
Advisors Inc. Profit Sharing Trust, whose address is 2655 Le Jeune Road, Coral
Gables, Florida 33134 (the "Plan"), Alberto W. Vilar and Gary A. Tanaka 
(sometimes hereinafter collectively referred to as the "Reporting Persons").  
Although this statement is being made jointly by the Reporting Persons, each of 
them expressly disaffirms membership in any group under Rule 13d-5 under the 
Securities Exchange Act of 1934, as amended (the "Exchange Act"), or 
otherwise.  Amerindo and Amerindo Panama are sometimes hereinafter collectively 
referred to as the "Advisor Entities."

           Each of the Advisor Entities is an investment advisor, and all of the
subject securities have been purchased by the Advisor Entities (or, in the case
of securities held, by the Plan) in the ordinary course of their respective
businesses as investment advisors and not with the purpose of effecting
change or influencing the control of the issuer or in connection with or as a
participant in any transaction having such purpose or effect, including any
transaction subject to Rule 13d-3(b) under the Exchange Act.  Amerindo is
registered as an investment advisor under the Investment Advisors Act of 1940,
as amended.  Messrs. Vilar and Tanaka are the sole shareholders and directors 
of each of the Advisor Entities, and Mr. Vilar is sole trustee of the Plan
(which is a qualified employee benefit plan).  Because each of the Advisor 
Entities is obligated to act in the best interests of its respective clients 
and in accordance with the respective mandates of those clients, and because
the trustee of the Plan is required to act in the best interest of the
beneficiaries thereof, there is no agreement between or among any of the 
Reporting Persons to act together with respect to the issuer or its 
securities, except that they may, from time to time and provided that 
transactions are otherwise being effected at the same time, aggregate orders 
for client accounts in order to receive more favorable trading terms.

     (d-e) This statement is being filed as to the Common Stock of 
Aronex Pharmaceuticals Inc., Cusip Number 042666107.

<PAGE>

Item 3.  If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b),
- ------   check whether the person filing is a:

     (a-g) Inapplicable.

     (h)   This statement is being filed jointly by the Reporting Persons, 
although each of them expressly disaffirms membership in any group under Rule
13d-5 under the Exchange Act.

Item 4.  Ownership.
- ------   ---------

     (a-c) The following table sets forth for each of the Advisor Entities and
for the Plan the aggregate number of shares of the Common Stock of the Issuer
beneficially owned by such person as of December 31, 1996, and the percentage
which such shares constitute of the total number of shares outstanding, as
reflected on the Issuer's Form 10Q for the Quarter ended September 30, 1996
(with beneficial ownership determined as set forth in Rule 13d-3 under the
Exchange Act, but with beneficial ownership being expressly disclaimed). Messrs.
Vilar and Tanaka, as the sole shareholders and directors of the Advisor
Entities, share with each other investment and dispositive power as to all
of the shares shown as owned by the Advisor Entities, who otherwise have sole 
investment and dispositive power with respect thereto, except that each client 
of the Advisor Entities has the unilateral right to terminate the advisory 
agreement with the Advisor Entity in question on notice which typically need 
not exceed 30 days.  Mr. Vilar is sole trustee of the Plan.


Name                         No. of Shares                   Percent of Class
- ----                         -------------                   ----------------

Amerindo                       1,010,000                            6.94%

Amerindo Panama                   21,250                            0.14%

Plan                              10,000                            0.07%

Alberto W. Vilar               1,041,250                            7.15%

Gary A. Tanaka                 1,031,250                            7.08%




<PAGE>


Item 5.  Ownership of Five Percent or Less of a Class.
- ------   --------------------------------------------

         Inapplicable.


Item 6.  Ownership of More Than Five Percent on Behalf of Another Person.
- ------   ---------------------------------------------------------------

         The subject shares are all owned by clients of the Advisor Entities 
or by the Plan.  No such person's interest in the securities included in this 
report exceeds 5% of the class outstanding.

Item 7.  Identification and Classification of the Subsidiary Which
- ------   ---------------------------------------------------------
         Acquired the Security Being Reported on By the Parent Holding
         -------------------------------------------------------------
         Company.
         -------

         Inapplicable.


Item 8.  Identification and Classification of Members of the Group.
- ------   ---------------------------------------------------------

    (a-c) This statement is being filed by Amerindo Investment Advisors Inc., a
California corporation whose principal executive offices are located at One
Embarcadero Center, Suite 2300, San Francisco, California, 94111 ("Amerindo"),
Amerindo Investment Advisors, Inc., a Panama corporation, whose principal 
executive offices are located at Edificio Sucre, Calle 48 Este, Bella Vista, 
Apartado 6277, Panama 5, Panama ("Amerindo Panama"), the Amerindo Investment
Advisors Inc. Profit Sharing Trust, whose address is 2655 Le Jeune Road, Coral
Gables, Florida 33134 (the "Plan"), Alberto W. Vilar and Gary A. Tanaka 
(sometimes hereinafter collectively referred to as the "Reporting Persons").  
Although this statement is being made jointly by the Reporting Persons, each of 
them expressly disaffirms membership in any group under Rule 13d-5 under the 
Securities Exchange Act of 1934, as amended (the "Exchange Act"), or 
otherwise.  Amerindo and Amerindo Panama are sometimes hereinafter collectively 
referred to as the "Advisor Entities."

           Each of the Advisor Entities is an investment advisor, and all of the
subject securities have been purchased by the Advisor Entities (or in the case
of securities held, by the Plan) in the ordinary course of their respective 
businesses as investment advisors and not with the purpose of effecting change 
or influencing the control of the issuer or in connection with or as a 
participant in any transaction having such purpose or effect, including any 
transaction subject to Rule 13d-3(b) under the Exchange Act.  Amerindo is 
registered as an investment advisor under the Investment Advisors Act of 1940, 
as amended.  Messrs. Vilar and Tanaka are the sole shareholders and directors 
of each of the Advisor Entities, and Mr. Vilar is sole trustee of the Plan 
(which is a qualified employee benefits plan).  Because each of the Advisor 
Entities is obligated to act in the best interests of its respective clients 
and in accordance with the respective mandates of those clients to act in the 
best interest of the beneficiaries thereof, and because the trustee of the Plan
is required to act in the best interest of the beneficiaries thereof, there is 
no agreement between or among any of the Reporting Persons to act together with 
respect to the issuer or its securities, except that they may, from time to 
time and provided that transactions are otherwise being effected at the same 
time, aggregate orders for client accounts in order to receive more favorable 
trading terms.

     (d-e) This statement is being filed as to the Common Stock of 
Aronex Pharmaceuticals Inc., Cusip Number 042666107.


Item 9.   Notice of Dissolution of Group.
- ------    ------------------------------

          Inapplicable.

<PAGE>

Item 10.  Certification.
- -------   -------------

     By signing below, the undersigned certify that, to the best of their 
knowledge and belief, the securities referred to above were acquired in the 
ordinary course of business and were not acquired for the purpose of and do 
not have the effect of changing or influencing the control of the issuer of 
such securities and were not acquired in connection with or as a participant 
in any transaction having such purpose or effect.


                                 SIGNATURES

          After reasonable inquiry and to the best of the knowledge and belief
of the undersigned, we certify that the information set forth in this
statement is true, complete and correct.

                                         AMERINDO INVESTMENT ADVISORS INC., 
                                         a California corporation


                                         By: /s/ Alberto W. Vilar
                                             -------------------------------
                                             ALBERTO W. VILAR, PRESIDENT

 
                                         AMERINDO INVESTMENT ADVISORS, INC.,
                                         a Panama corporation


                                         By: /s/ Alberto W. Vilar
                                             ------------------------------
                                             ALBERTO W. VILAR, DIRECTOR
  
         
                                         AMERINDO INVESTMENT ADVISORS INC.
                                         PROFIT SHARING TRUST

                                         By: /s/ Alberto W. Vilar
                                             ------------------------------
                                             ALBERTO W. VILAR, TRUSTEE 

                                      

                                         By: /s/ Alberto W. Vilar
                                             ------------------------------
                                             ALBERTO W. VILAR

                                             /s/ Gary A. Tanaka
                                             ------------------------------
                                             GARY A. TANAKA

<PAGE>

                                    EXHIBIT A

                            ARONEX PHARMACEUTICALS INC.

                                  COMMON STOCK

                                   042666107

                                        
We hereby agree that the within Statement on Schedule 13G/A regarding our 
beneficial ownership of Common Stock is filed on behalf of each of us.


                                        AMERINDO INVESTMENT ADVISORS INC.,
                                        a California corporation

                                        By:  /s/ Alberto W. Vilar
                                            ---------------------------------
                                             ALBERTO W. VILAR, PRESIDENT


                                        AMERINDO INVESTMENT ADVISORS, INC.,
                                        a Panama corporation

                                        By:  /s/ Alberto W. Vilar
                                            ---------------------------------
                                             ALBERTO W. VILAR, DIRECTOR


                                        AMERINDO INVESTMENT ADVISORS INC.
                                        PROFIT SHARING TRUST

                                        By:  /s/ Alberto W. Vilar
                                            ---------------------------------
                                             ALBERTO W. VILAR, TRUSTEE


                                        By: /s/ Alberto W. Vilar
                                            ---------------------------------
                                            ALBERTO W. VILAR

                                            /s/ Gary A. Tanaka
                                            ---------------------------------
                                            GARY A. TANAKA



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