ARONEX PHARMACEUTICALS INC
SC 13D/A, 1997-12-03
PHARMACEUTICAL PREPARATIONS
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                    SECURITIES AND EXCHANGE COMMISSION
                          WASHINGTON, D.C.  20549
                                     
                              SCHEDULE 13D/A
                     (AMENDMENT NO. 1 TO SCHEDULE 13D)
                                     
                 Under the Securities Exchange Act of 1934
                                     
                       ARONEX PHARMACEUTICALS, INC.
- ---------------------------------------------------------------------------
                             (Name of Issuer)
                                     
            Shares of Common Stock, par value $0.001 per share
- ---------------------------------------------------------------------------
                      (Title of Class of Securities)
                                     
                                 042666206
- ---------------------------------------------------------------------------
                              (CUSIP NUMBER)
                                     
        PARAGON ASSOCIATES AND PARAGON ASSOCIATES II JOINT VENTURE
                       THE BRADBURY DYER FOUNDATION
                            500 Crescent Court
                                 Suite 260
                           Dallas, Texas  75201
                         Tel. No.: (214) 871-3700
- ---------------------------------------------------------------------------
               (Name, Address and Telephone Number of Person
             Authorized to Receive Notices and Communications)
                                     
                            - with copies to -
                              Ford Lacy, P.C.
                  Akin, Gump, Strauss, Hauer & Feld, LLP
                      1700 Pacific Avenue, Suite 4100
                         Dallas, Texas 75201-4618
                              (214) 969-2800
                                     
                             November 26, 1997
- ---------------------------------------------------------------------------
          (Date of event which requires filing of this statement)
                                     
                                     
If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is
filing this schedule because of Rule 13d-1(b)(3) or (4) check the following
box [ ]

The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities
Exchange Act of 1934, as amended ("Act"), or otherwise subject to the
liabilities of that section of the Act but shall be subject to all other
provisions of the Act.


CUSIP No. 042666206           13D

1    NAME OF REPORTING PERSONS
     S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

     Paragon Associates and
     Paragon Associates II Joint Venture - 75-1956332

     The Bradbury Dyer Foundation - 75-2629363

2    CHECK THE APPROPRIATE BOX IF A MEMBER OF
     A GROUP*                                         (a) [   ]
                                                      (b) [   ]


3    SEC USE ONLY


4    SOURCE OF FUNDS*

     WC

5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS
     IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e)            [   ]

6    CITIZENSHIP OR PLACE OF ORGANIZATION

     Texas

     NUMBER OF      7    SOLE VOTING POWER           1,015,000
     SHARES
     BENEFICIALLY   8    SHARED VOTING POWER         0
     OWNED BY
     EACH           9    SOLE DISPOSITIVE POWER      1,015,000
     REPORTING
     PERSON WITH    10   SHARED DISPOSITIVE POWER    0

11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,015,000

12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
     CERTAIN SHARES*                                      [   ]

13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     6.58%

14   TYPE OF REPORTING PERSON*

     OO


*SEE INSTRUCTIONS BEFORE FILLING OUT



                AMENDMENT NO. 1 TO SCHEDULE 13D

     This Amendment No. 1 to Schedule 13D is filed as an amendment to the
initial statement on Schedule 13D relating to shares of common stock, par
value $0.001 per share ("Common Stock"), of Aronex Pharmaceuticals, Inc.
(the "Issuer"), as filed with the Securities and Exchange Commission on
October 20, 1997 (the "Initial Schedule 13D").  The Initial Schedule 13D is
hereby amended and supplemented as follows:

ITEM 2.   IDENTITY AND BACKGROUND

     Item 2 of the Initial Schedule 13D is hereby amended and restated in
its entirety to read as follows:

          This Amendment No. 1 Schedule 13D is filed by The Bradbury Dyer
Foundation (the "Foundation") and by a joint venture formed by (i) Paragon
Associates, a Texas limited partnership ("Paragon") and (ii) Paragon
Associates II, a Texas limited partnership ("Paragon II").  Bradbury Dyer
III is the president of the Foundation, the sole general partner of Paragon
and Paragon II and the authorized agent to the joint venture, which is
hereinafter referred to as "Paragon JV."

          The business address of the Foundation, Paragon, Paragon II,
Paragon JV and Mr. Dyer is 500 Crescent Court, Suite 260, Dallas, Texas
75201.  The Foundation is a charitable, tax-free foundation.  The principal
business of Paragon JV is the joint management of the assets and activities
of Paragon and Paragon II.  The principal business of Paragon and Paragon
II is investment in and trading of capital stocks, warrants, bonds, notes,
debentures and other securities.  The present principal occupations or
employments of Mr. Dyer are management of his personal investments,
president of the Foundation, general partner of Paragon and Paragon II, and
agent for Paragon JV.  Mr. Dyer is a citizen of the United States.

          Neither the Foundation, Paragon, Paragon II, Paragon JV nor Mr.
Dyer has, during the past five years, been convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or been a
party to a civil proceeding of a judicial or an administrative body of
competent jurisdiction and as a result of such proceeding was or is subject
to a judgment, decree or final order enjoining future violations of, or
prohibiting or mandating activities subject to, federal or state securities
laws or finding any violation with respect to such laws.

ITEM 3.   SOURCE AND AMOUNT OF FUNDS

     Item 3 of the Initial Schedule 13D is hereby amended and restated in
its entirety to read as follows:

          As of December 2, 1997, the Foundation and Paragon JV had
invested $5,121,732 in shares of Common Stock of Aronex Pharmaceuticals,
Inc. (the "Issuer") as described below in Item 5. The source of these funds
was the respective working capital of the Foundation and Paragon JV.

ITEM 4.   PURPOSE OF THE TRANSACTION

     Item 4 of the Initial Schedule 13D is hereby amended and restated in
its entirety to read as follows:

          The Foundation and Paragon JV acquired shares of the Issuer's
Common Stock for investment purposes and do not have any present plans or
proposals that relate to or would result in any change in the business,
policies, management, structure or capitalization of the Issuer, but the
Foundation and Paragon JV reserve the right to consider or make such plans
and/or proposals in the future.  The Foundation and Paragon JV reserve the
right to acquire, or dispose of, additional securities of the Issuer, in
the ordinary course of business, to the extent deemed advisable in light of
their general investment and trading policies, market conditions or other
factors.  While not currently anticipated, the Foundation and Paragon JV
may in the future contact other shareholders regarding potential strategies
to increase shareholder value.  Other than as described above, the
Foundation and Paragon JV have no present plans or proposals which would
result in any of the following:

             1)       any extraordinary corporate transaction, such as a merger,
         reorganization or liquidation, involving the Issuer or any of its
         subsidiaries;

             2)       any sale or transfer of a material amount of assets of 
         the Issuer or any of its subsidiaries;

             3)       any change in the present board of directors or managers 
         of the Issuer;

             4)       any material change in the present capitalization or 
         dividend policy of the Issuer;

             5)       any other material change in the Issuer's business or 
         corporate structure;

             6)       any change in the Issuer's charter, by-laws or instruments
         corresponding thereto or other actions which may impede the acquisition
         of control of the Issuer by any person;

             7)       causing a class of securities of the Issuer to be delisted
         from a national securities exchange or to cease to be authorized to be
         quoted in an interdealer quotation system of a registered national 
         securities association;

             8)       causing a class of securities of the Issuer to become 
         eligible for termination of registration pursuant to Section 12(g)(4) 
         of the Act; or

             9)       any action similar to any of those enumerated above.

ITEM 5.   INTEREST IN SECURITIES OF THE ISSUER

     Item 5 of the Initial Schedule 13D is hereby amended by amending and
restating Items 5(a), (b) and (c) as follows:

          (a) As of September 30, 1997, and according to the Issuer's most
recent Quarterly Report on Form 10-Q, there were issued and outstanding
15,421,809 shares of Common Stock.  As of the date hereof, Paragon JV (in
carrying out the purposes of Paragon and Paragon II) has beneficial
ownership of 1,000,000 such shares, representing approximately 6.48% of the
Common Stock of the Issuer.  Under the terms of the joint venture agreement
of Paragon JV, a copy of which is herewith filed as Annex A and
incorporated herein by reference, Paragon and Paragon II have beneficial
ownership of such shares in proportion to their respective accounts in the
joint venture.  As of the date hereof, the Foundation has beneficial
ownership of 15,000 shares of the Insurer's Common Stock, representing
approximately 0.10% of the Common Stock of the Issuer.  Mr. Dyer does not
have direct beneficial ownership of any of the foregoing shares; however,
Mr. Dyer, as president of the Foundation, sole general partner of Paragon
and Paragon II, and agent for Paragon JV, may be deemed, for purposes of
determining beneficial ownership pursuant to Rule 13d-3, to have indirect
beneficial ownership of such shares.

          (b) Paragon JV has the sole power to vote or to direct the vote
of and the sole power to dispose or to direct the disposition of a total of
1,000,000 shares of Common Stock of the Issuer; however, Paragon and
Paragon II, as co-venturers in Paragon JV, each hold an undivided interest
in such shares based on their respective accounts in Paragon JV, and may be
deemed, for purposes of determining beneficial ownership pursuant to Rule
13d-3, to have shared power with Paragon JV to vote or to direct the vote
of and to dispose or to direct the disposition of such shares.  The
Foundation has sole power to vote or direct the vote of and the sole power
to dispose or to direct the disposition of a total of 15,000 shares of
Common Stock of the Issuer. Mr. Dyer, as president of the Foundation, sole
general partner of Paragon and Paragon II and managing agent for Paragon
JV, may be deemed, for purposes of determining beneficial ownership
pursuant to Rule 13d-3, to have shared power with Paragon JV and the
Foundation to vote or to direct the vote of and to dispose or to direct the
disposition of such shares.

          (c) The transactions in the Issuer's securities by the Foundation
and Paragon JV during the period of October 10, 1997 to December 2, 1997
are listed as Annex B attached hereto and made apart hereof.

                                     
                                  ANNEX A


                            JOINT OPERATION AND
                      ACCOUNTING PROCEDURES AGREEMENT

     AGREEMENT dated as of January 1, 1984 by and among Bradbury Dyer III
(hereinafter called "Dyer"), an individual residing in Dallas, Texas,
Paragon Associates (hereinafter called "Old Paragon"), a Texas limited
partnership of which Dyer is the general partner, and Paragon Associates II
(hereinafter called "Paragon II"), a Texas limited partnership of which
Dyer is the general partner.  The address of Dyer, Old Paragon and Paragon
II is Suite 2340, One Dallas Centre, 350 North St. Paul, Dallas, Texas
75201.



     Note:  The Introductory Statement to this Agreement has been deleted
     because it does not govern the terms of the joint operation of the
     parties hereto and does contain certain information which the
     reporting persons desire to hold in confidence.















                                 AGREEMENT

     1.   Old Paragon and Paragon II hereby form a joint venture for the
purpose of jointly carrying out the purposes set forth in the Limited
Partnership Agreements of Old Paragon and Paragon II and accounting for
their commingled assets and liabilities exclusive of the contingent
liabilities of the Metropolitan Claims which shall be retained by, and
remain solely the obligation of, Old Paragon.  Each party hereto may
withdraw from the joint venture its share of the assets subject to its
share of the liabilities at any time.

     2.   Old Paragon confirms to Paragon II that Old Paragon intends
solely to retain and does retain any and all liability which it might have
with respect to the Metropolitan Claims and Old Paragon hereby indemnifies
the joint venture and Paragon II and each person or entity who is at any
time a limited partner of Paragon II against any loss or liability with
respect to, or resulting from, the Metropolitan Claims and any and all
costs and expenses, including attorney's fees, which any of them may incur
in connection with the defense thereof or the enforcement of this
provision.  Dyer will not permit capital withdrawals from Old Paragon which
would impair its ability to satisfy any liability which it might have with
respect to the Metropolitan Claims or with respect to obligations under
this paragraph 2.

     3.   Dyer, as agent for the joint venture, hereby is authorized to
open any and all bank, brokerage or other accounts necessary or useful for
the joint operation of Old Paragon and Paragon II.  Any bank, broker or
other person may conclusively rely on this agreement as evidence of Dyer's
authority to so act.

     4.   Old Paragon shall have a _______% interest in the joint venture
and Paragon II shall have a ________% interest in the joint venture.  Such
interests are based upon Old Paragon's net worth (net of withdrawals) at
December 31, 1983 of $_______________ and Paragon II's net worth as of
January 1, 1984 of $______________.  These sharing ratios will be adjusted
to reflect any contributions or withdrawals by either Old Paragon or
Paragon II.  Each of Old Paragon and Paragon II hereby assumes through the
joint venture a pro rata interest in each contributed asset and liability
of the other, it is being understood and agreed that no liability with
respect to the Metropolitan Claims is being assumed through the joint
venture or otherwise. Further, Old Paragon and Paragon II each agree that
any gain or loss realized for federal income tax purposes which is
attributable to unrealized gain or loss existing on January 1, 1984 shall
be included in the gain or loss of the contributing party.

     5.   Old Paragon and Paragon II agree that each will separately
account for its interest in the joint venture and each will separately
prepare and file all appropriate tax returns.

     6.   Dyer, as agent for the joint venture, will make any and all tax
filings and elections for the joint venture as appropriate to reflect the
separate and distinct nature of the interests of Old Paragon and Paragon II
in the joint venture.

     7.   The authority of Dyer, as agent for the accounts of the joint
venture, shall be the same as his authority with respect to the separate
assets and liabilities of Old Paragon and Paragon II under the Limited
Partnership Agreement for Paragon Associates (as amended) and the Limited
Partnership Agreement for Paragon Associates II.

     8.   This Agreement shall be effective as of January 1, 1984.  Any
activity in any account of Old Paragon or Paragon II since that date will
be deemed to be for the account of the joint venture.

     9.   Paragraph 2 of this Agreement may not be amended or terminated
without the prior written consent of each person or entity which becomes a
limited partner of Paragon II any time on or after January 1, 1984.

     10.  Nothing in this Agreement shall prevent Bradbury Dyer III from
causing the termination of the joint venture when there is no longer
pending or threatened against Bradbury Dyer III or Paragon Associates any
Metropolitan Claim.

                         [SIGNATURE PAGE FOLLOWS]
                                     

     EXECUTED at Dallas, Texas as of the day and year first above written.

                                   PARAGON ASSOCIATES

                                   By:/S/ BRADBURY DYER III
                                      ----------------------------
                                        Bradbury Dyer III
                                        General Partner


                                   PARAGON ASSOCIATES II

                                   By:/S/ BRADBURY DYER III
                                      ----------------------------
                                        Bradbury Dyer III
                                        General Partner


                                   /S/ BRADBURY DYER III
                                   ----------------------------
                                   BRADBURY DYER III


                                  ANNEX B

                                PARAGON JV

 Transaction         Buy/Sell     Quantity     Price per
     Date                         (shares)     Share ($)
 ------------       ---------    ---------     ---------
   
   10/27/97           Buy         20,000          5.65
   11/03/97           Buy          3,000          5.31
   11/07/97           Buy         10,000          5.63
   11/12/97           Buy         15,000          5.31
   11/13/97           Buy         20,000          5.38
   11/14/97           Buy         10,000          5.44
   11/17/97           Buy         20,000          5.27
   11/18/97           Buy         10,000          5.25
   11/19/97           Buy         20,000          5.31
   11/21/97           Buy         10,000          5.38
   11/25/97           Buy         15,000          5.25
   11/26/97           Buy         30,000          5.09
   11/28/97           Buy          5,000          5.06
   12/01/97           Buy          3,500          5.13
                                 -------
                                 191,500
                                 =======




                              THE FOUNDATION

 Transaction         Buy/Sell     Quantity     Price per
     Date                         (shares)     Share ($)
 ------------       ---------    ---------     ---------
   
   12/01/97           Buy          5,000          5.13
   12/02/97           Buy         10,000          5.13
                                  ------
                                  15,000
                                  ======
   


                                 SIGNATURE

    After reasonable inquiry and to the best of my knowledge and belief,
the undersigned certifies that the information set forth in this statement
is true, complete and correct.


Dated: December 2, 1997



                              Paragon Associates and Paragon Associates II
                              Joint Venture


                              By:  /S/ BRADBURY DYER III
                                 -----------------------------------
                                 Bradbury Dyer III, Authorized Agent


                              The Bradbury Dyer Foundation


                              By:  /S/ BRADBURY DYER III
                                 -----------------------------------
                                 Bradbury Dyer III, President





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