ARONEX PHARMACEUTICALS INC
DEF 14A, 1998-04-29
PHARMACEUTICAL PREPARATIONS
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                            SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934


                          Filed by the Registrant [X]

Filed by a Party other than the Registrant [    ]

Check the appropriate box:

[ ]   Preliminary Proxy Statement

[ ]   Confidential,  for Use of the  Commission  Only  (as  permitted  by Rule
       14a-6(e)(2))

[X]   Definitive Proxy Statement

[ ]   Definitive Additional Materials

[ ]   Soliciting Material Pursuant to ss. 240.14a-11(c) or ss. 240.14a-12

                          ARONEX PHARMACEUTICALS, INC.
                (Name of Registrant as Specified In Its Charter)


     (Name of Person(s) Filing Proxy Statement if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[X]  No fee required.

[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

     1)   Title of each class of securities to which transaction applies:

     2)   Aggregate number of securities to which transaction applies:

     3)   Per unit  price  or other  underlying  value of  transaction  computed
          pursuant to Exchange  Act Rule 0-11 (Set forth the amount on which the
          filing fee is calculated and state how it was determined):

     4)   Proposed maximum aggregate value of transaction:

     5)   Total fee paid:



[ ] Fee paid previously with preliminary materials.  

[ ] Check box if any part of the fee is offset as provided  by  Exchange  Act
    Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was
    paid  previously.  Identify the previous filing by  registration  statement
    number, or the Form or Schedule and the date of its filing.

     1)   Amount Previously Paid:

     2)   Form, Schedule or Registration Statement No.:

     3)   Filing Party:

     4)   Date Filed:




<PAGE>




                                [GRAPHIC OMITTED]





                          8707 Technology Forest Place
                         The Woodlands, Texas 77381-1191






                                 April 30, 1998




TO OUR STOCKHOLDERS:

       You  are  cordially   invited  to  attend  the  1998  Annual  Meeting  of
Stockholders of Aronex  Pharmaceuticals,  Inc. to be held on Thursday,  June 11,
1998, at 1:30 p.m., local time, at The Woodlands  Executive  Conference  Center,
2301 North Millbend Drive, The Woodlands, Texas. A Notice of the Annual Meeting,
Proxy Statement and form of proxy are enclosed with this letter.

       We  encourage  you to read the  Notice of the  Annual  Meeting  and Proxy
Statement  so that you may be  informed  about the  business  to come before the
meeting.  Your participation in the Company's business is important,  regardless
of the number of shares  that you hold.  To ensure  your  representation  at the
meeting,  please  promptly  sign and return the  accompanying  proxy card in the
postage-paid envelope.

        We look forward to seeing you on June 11, 1998.


                                             Sincerely,



                                             Geoffrey F. Cox, Ph.D.
                                             Chief Executive Officer


<PAGE>





                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                            TO BE HELD JUNE 11, 1998


To the Stockholders of Aronex Pharmaceuticals, Inc.:

         The Annual  Meeting of  Stockholders  (the "Annual  Meeting") of Aronex
Pharmaceuticals,  Inc. (the "Company") will be held on Thursday,  June 11, 1998,
at 1:30 p.m., local time, at The Woodlands  Executive  Conference  Center,  2301
North Millbend Drive, The Woodlands, Texas, for the following purposes:

                  1. To elect  two Class I  directors  of the  Company,  each to
         serve until the Company's 2001 Annual Meeting of  Stockholders or until
         their respective successors have been duly elected and qualified;

                  2.  To  vote  upon  a  proposal   to  approve  and  adopt  the
         Aronex Pharmaceuticals, Inc. 1998 Stock Option Plan;

                  3. To ratify and approve the  appointment  of Arthur  Andersen
         LLP as the Company's independent public accountants for its fiscal year
         ending December 31, 1998; and

                  4. To act upon such other business as may properly come before
         the meeting or any adjournments thereof.

         Only  stockholders of record at the close of business on April 15, 1998
will be entitled to notice of and to vote at the Annual Meeting.

         It is important  that your shares be  represented at the Annual Meeting
regardless of whether you plan to attend. THEREFORE,  PLEASE MARK, SIGN AND DATE
THE ENCLOSED PROXY AND RETURN IT IN THE  ACCOMPANYING  POSTAGE-PAID  ENVELOPE AS
PROMPTLY AS POSSIBLE.  If you are present at the Annual Meeting,  and wish to do
so, you may revoke the proxy and vote in person.

                                             By Order of the Board of Directors,


                                             Terance A. Murnane
                                             Secretary

The Woodlands, Texas
April 30, 1998


<PAGE>



                          ARONEX PHARMACEUTICALS, INC.
                          8707 Technology Forest Place
                         The Woodlands, Texas 77381-1191

                           ---------------------------


                                 PROXY STATEMENT
                                       FOR
                         ANNUAL MEETING OF STOCKHOLDERS


                            To Be Held June 11, 1998



                    SOLICITATION AND REVOCABILITY OF PROXIES

         The accompanying Proxy is solicited by the Board of Directors of Aronex
Pharmaceuticals,  Inc.  (the  "Company")  to be voted at the  Annual  Meeting of
Stockholders of the Company to be held on Thursday, June 11, 1998, at 1:30 p.m.,
local time, at The Woodlands  Executive  Conference Center,  2301 North Millbend
Drive,  The  Woodlands,  Texas,  for the purposes set forth in the  accompanying
Notice of Annual  Meeting  of  Stockholders,  and at any  adjournment(s)  of the
Annual Meeting. If the accompanying Proxy is properly executed and returned, the
shares it represents  will be voted at the Annual Meeting in accordance with the
directions  noted thereon or, if no direction is indicated,  it will be voted in
favor of the proposals described in this Proxy Statement. In addition, the Proxy
confers  discretionary  authority to the persons named in the Proxy  authorizing
those  persons  to vote,  in their  discretion,  on any other  matters  properly
presented at the Annual  Meeting.  The Board of Directors is not currently aware
of any such other matters.

         Each stockholder of the Company has the  unconditional  right to revoke
his Proxy at any time  prior to its  exercise,  either  in person at the  Annual
Meeting or by written  notice to the  Company  addressed  to  Secretary,  Aronex
Pharmaceuticals,  Inc.,  8707  Technology  Forest Place,  The  Woodlands,  Texas
77381-1191. No revocation by written notice will be effective unless such notice
has been received by the Secretary of the Company prior to the day of the Annual
Meeting or by the inspector of election at the Annual Meeting.

         The  principal  executive  offices of the  Company  are located at 8707
Technology Forest Place, The Woodlands,  Texas 77381-1191.  This Proxy Statement
and the  accompanying  Notice of Annual  Meeting of  Stockholders  and Proxy are
being mailed to the Company's stockholders on or about April 30, 1998.

         In  addition  to the  solicitation  of  proxies  by use of  this  Proxy
Statement,  directors,  officers  and  employees  of the Company may solicit the
return of proxies by mail, personal interview,  telephone or telegraph. Officers
and employees of the Company will not receive additional  compensation for their
solicitation efforts, but they will be reimbursed for any out-of-pocket expenses
incurred.  Brokerage houses and other custodians,  nominees and fiduciaries will
be requested, in connection with the stock registered in their names, to forward
solicitation materials to the beneficial owners of such stock.

         All costs of preparing,  printing, assembling and mailing the Notice of
Annual Meeting of Stockholders, this Proxy Statement, the enclosed form of Proxy
and any  additional  materials,  as well as the cost of forwarding  solicitation
materials to the beneficial owners of stock and all other costs of solicitation,
will be borne by the Company.


                                                        -1-

<PAGE>



                             PURPOSES OF THE MEETING

         At the Annual  Meeting,  the  Company's  stockholders  will be asked to
consider and act upon the following matters:

          1.   The  election of two Class I directors  of the  Company,  each to
               serve until the Company's 2001 Annual Meeting of  Stockholders or
               until  their  respective  successors  have been duly  elected and
               qualified;

          2.   A proposal to approve and adopt the Aronex Pharmaceuticals,  Inc.
               1998 Stock Option Plan;

          3.   A  proposal  to ratify  and  approve  the  appointment  of Arthur
               Andersen LLP as the Company's  independent public accountants for
               its fiscal year ending December 31, 1998; and

          4.   Such other  business as may  properly  come before the meeting or
               any adjournments thereof.


                                QUORUM AND VOTING

         The close of  business  on April 15,  1998 has been fixed as the record
date (the "Record Date") for the determination of stockholders  entitled to vote
at the Annual Meeting and any adjournment(s) thereof. As of the Record Date, the
Company  had issued and  outstanding  15,467,281  shares of Common  Stock and no
shares of the Company's Preferred Stock, par value $.001 per share.

         Each stockholder of record of Common Stock will be entitled to one vote
per share on each matter that is called to vote at the Annual Meeting.

         The  presence,  either  in  person or by  proxy,  of the  holders  of a
majority of the outstanding  shares of Common Stock is necessary to constitute a
quorum at the Annual Meeting.  Abstentions and broker  non-votes are counted for
purposes  of  determining  whether  a quorum is  present.  A  plurality  vote is
required for the election of directors.  Accordingly,  if a quorum is present at
the Annual Meeting,  the two persons receiving the greatest number of votes will
be elected to serve as directors.  Withholding  authority to vote for a director
nominee and broker  non-votes in the  election of directors  will not affect the
outcome of the election of  directors.  All other matters to be voted on will be
decided  by the vote of the  holders  of a  majority  of the  shares  present or
represented  at the Annual  Meeting and entitled to vote on such matter.  On any
such matter,  an  abstention  will have the same effect as a negative  vote but,
because  shares  held by  brokers  will not be  considered  entitled  to vote on
matters as to which the brokers withhold authority,  a broker non-vote will have
no effect on such vote.

         All Proxies that are properly  completed,  signed and returned prior to
the  Annual  Meeting  will be voted.  Any Proxy  given by a  stockholder  may be
revoked at any time before it is  exercised by the  stockholder  (i) filing with
the  Secretary  of the Company an  instrument  revoking it, (ii)  executing  and
returning a Proxy bearing a later date or (iii) attending the Annual Meeting and
expressing a desire to vote his shares of Common Stock in person.  Votes will be
counted by American Stock Transfer & Trust Company, the Company's transfer agent
and registrar.




                                                        -2-

<PAGE>



                               PROPOSAL NUMBER 1:
                              ELECTION OF DIRECTORS

         The  Company's  Restated  Certificate  of  Incorporation,  as  amended,
provides that the Board of Directors of the Company is divided or  "classified,"
with respect to the time for which they  individually  hold  office,  into three
classes  ("Classes I, II and III"),  with each class consisting of, as nearly as
possible,  one third of the entire Board.  The  Company's  Board of Directors is
currently  fixed at six members.  Each  director is elected to hold office for a
term ending on the date of the third annual meeting following the annual meeting
at which such director was elected.  The current term for Class I Directors will
expire  at the  Annual  Meeting.  The  current  terms for Class II and Class III
Directors  will  expire at the 2000 and 1999 Annual  Meetings  of  Stockholders,
respectively.

         The  Board of  Directors  has  nominated  and urges you to vote for the
election of the two nominees  identified below, who have been nominated to serve
as Class I directors for a three-year  term or until their  successors  are duly
elected and  qualified.  Each of the  nominees  listed  below is a member of the
Company's present Board of Directors. Proxies solicited hereby will be voted for
both nominees unless stockholders specify otherwise in their Proxies.

         If, at the time of or prior to the Annual Meeting,  any of the nominees
should be unable or decline to serve, the  discretionary  authority  provided in
the Proxy may be used to vote for a substitute or substitutes  designated by the
Board of  Directors.  The Board of  Directors  has no reason to believe that any
substitute nominee or nominees will be required.

Nominees for Director

         The two  nominees  for  election  as  Class  I  directors  and  certain
additional information with respect to each of them, are as follows:

<TABLE>
<CAPTION>
                                                                                                     Year First
                Name                      Age             Position with the Company               Became a Director
<S>                                       <C>             <C>                                     <C>   
                ----                      ---             -------------------------               -----------------
Martin P. Sutter.....................     43                 Director (Class I)                         1986
Ronald J. Brenner, Ph.D..............     64                 Director (Class I)                         1995
</TABLE>

         Martin P. Sutter, a co-founder of the Company, has served as a Director
of the Company  since June 1986 and served as Chairman of the Board of Directors
of the  Company  from 1986 to 1997.  Since  July 1988,  Mr.  Sutter has been the
Managing  General  Partner of The Woodlands  Venture  Partners,  L.P., a venture
capital  firm based in The  Woodlands,  Texas,  and the  General  Partner of The
Woodlands Venture Fund, L.P., one of the Company's  principal  stockholders.  In
addition,  Mr.  Sutter  has been a General  Partner  of Essex  Woodlands  Health
Ventures,  L.P. since  September 1994. From January 1985 to July 1988, he served
as  President  of The  Woodlands  Venture  Capital  Company.  Mr.  Sutter is the
Chairman of the Board of Directors of Zonagen,  Inc.,  a  biotechnology  company
based in The Woodlands,  Texas, and a director of Targeted Genetics  Corporation
and several privately held healthcare and biotechnology companies.

     Ronald J. Brenner,  Ph.D.  has served as a member of the Board of Directors
since  September  1995.  Since 1988,  Dr.  Brenner has been a Vice  President of
Hillman Medical Ventures, Inc., a venture capital firm, and a general partner of
several  Hillman  investment  partnerships.  From 1984 to 1988,  Dr. Brenner was
President and Chief Executive  Officer of Cytogen  Corporation,  a biotechnology
company.  Prior to 1984, he was Vice President,  Corporate External Research, at
Johnson & Johnson, a major  pharmaceutical  company, and also served as Chairman
of McNeil  Pharmaceutical,  Ortho  Pharmaceutical Corp. and the Cilag Companies,
all  subsidiaries  of Johnson & Johnson.  Dr.  Brenner is a director  of Cytogen
Corporation and several privately held healthcare and environmental companies.

         The Board of  Directors  recommends  that  stockholders  vote "FOR" the
election of each of the above-named nominees.

                                                        -3-

<PAGE>



Current and Continuing Directors
<TABLE>

<CAPTION>

                         Name                            Age                           Position
<S>        
<S>                                                       <C>   <C>                                                 
Geoffrey F. Cox, Ph.D. (3)............................    54    Chairman of the Board of Directors (Class II) and
                                                                Chief Executive Officer
Gabriel Lopez-Berestein, M.D.(1)......................    50    Director (Class II) and Chief Scientific Advisor
Ronald J. Brenner, Ph.D...............................    64    Director (Class I)
James R. Butler(1) (3)................................    57    Director (Class III)
Martin P. Sutter(2) (3)...............................    43    Director (Class I)
Gregory F. Zaic(2)....................................    50    Director (Class III)
</TABLE>

- ---------------------------

(1)  Member of the Audit Committee of the Board of Directors

(2)  Member of the Compensation Committee of the Board of Directors

(3)  Member of the Nominating Committee of the Board of Directors

     Information regarding the business experience of Mr. Sutter and Dr. Brenner
is set forth above under the heading "-- Nominees for Director."

     Geoffrey  F. Cox,  Ph.D.  joined the  Company as  Chairman of the Board and
Chief Executive Officer in November 1997 and has served as a member of the Board
of Directors since January 1994. Dr. Cox joined Genzyme Corporation in 1984, was
appointed  Managing  Director  of  Genzyme,  Ltd.  (U.K.) in 1986,  Senior  Vice
President of worldwide  manufacturing  operations in May 1988 and Executive Vice
President in 1996,  with  responsibility  for  manufacturing  operations and the
Pharmaceuticals,  Diagnostic  Products and Genetic Diagnostic  Products units of
Genzyme.

     Gabriel Lopez-Berestein, M.D., a co-founder of the Company, has served as a
member of the Board of Directors  and the  Company's  Chief  Scientific  Advisor
since January 1988.  Dr.  Lopez-Berestein  is Professor of Medicine and Chief of
the  Immunobiology  and Drug  Carriers  Section at The  University of Texas M.D.
Anderson  Cancer  Center,  with which he has been  affiliated  since  1979.  Dr.
Lopez-Berestein  is  the  author  of  over  125  publications  in the  areas  of
macrophage research and drug carrier technology. Dr. Lopez-Berestein is also the
recipient  of a number of grants and awards,  including  a Scholar  Award of the
Leukemia Society of America and various NIH awards.

     James R. Butler has served as a member of the Board of Directors since June
1997.  Mr.  Butler is  Senior  Vice  President,  Sales  and  Marketing  for ALZA
Corporation,  a California-based  pharmaceutical company developing therapeutics
using its  proprietary  drug  delivery  systems.  Mr.  Butler has overseen  ALZA
Pharmaceuticals  since August 1993. ALZA  Pharmaceuticals has responsibility for
domestic sales and marketing,  government affairs, ex-U.S.  commercialization of
ALZA products,  new product  planning,  and ALZA scientific.  ALZA scientific is
responsible for all aspects of the ALZET(R)  product line. Prior to joining ALZA
in 1993,  Mr.  Butler was Vice  President  and General  Manager of Glaxo  Inc.'s
Corporate  Division.  Mr.  Butler held numerous  sales and  marketing  positions
during his 23- year tenure at Glaxo.

         Gregory F. Zaic has served as a member of the Board of Directors  since
September 1995. Mr. Zaic has been an investor  primarily  focused on medical and
life  science  investment  opportunities  since 1983.  He currently is a General
Partner of Prince  Ventures and has served as acting  president  and director of
many private and public companies,  including GenVec, Inc., Thiktilos,  Inc. and
Xylos  Corporation.  Before his  investment  career,  Mr. Zaic served in several
financial, technical, and operational capacities,  including heading the Special
Products  Division of Baxter,  a manufacturer  of custom medical devices for the
cardiopulmonary and intravenous solution administration markets.

                                                        -4-

<PAGE>





Directors' Meetings and Compensation

         During 1997,  the Board of  Directors  met eight times and took certain
additional  actions by unanimous  written  consent in lieu of  meetings.  During
1997, no director of the Company  attended fewer than 75 percent of the meetings
of the Board of  Directors,  with the  exception  of George  B.  Mackaness,  who
attended two of the three meetings held while he was a director.

         The  Company's  directors  do not  receive  any cash  compensation  for
service on the Board of Directors or any committee.  The directors are, however,
reimbursed  for expenses  incurred in connection  with  attending each Board and
committee  meeting.  Directors who are not employees of the Company are entitled
to participate in the Company's Amended and Restated 1993 Non-Employee  Director
Stock  Option  Plan  (the  "Director  Plan").  Under  the  Director  Plan,  each
non-employee  director  receives  (i) a grant of an  option to  purchase  25,000
shares of Common  Stock upon  their  initial  election  to the Board and (ii) an
annual  grant of an option to purchase  7,500 shares of Common Stock on December
31 of each year  provided  that such  director  has served as a director  for at
least  six  months  prior to the date of the  grant.  In  addition,  each of the
Company's  non-employee  directors  received  a grant of an option  to  purchase
16,250  shares of Common Stock in 1997 in  connection  with the amendment of the
Director Plan. The Director Plan also permits discretionary grants of options to
non-employee  directors  who do not serve on the  Compensation  Committee of the
Board of Directors.  In 1997, Mr. Sutter  received,  prior to his appointment to
the Compensation  Committee,  discretionary  grants of options  entitling him to
purchase 15,000 shares of Common Stock.

         The Company has a consulting  agreement  with Gabriel  Lopez-Berestein,
M.D., whereby the Company is committed to pay annual consulting fees of $156,000
for 1998,  1999 and 2000,  one-half of which is payable in cash and  one-half of
which is payable in shares of  restricted  Common  Stock.  The Company  paid Dr.
Lopez-Berestein  $156,000 in cash under a predecessor  agreement during the year
ended December 31, 1997.

Board Committees

         The Board of Directors  established a Nominating Committee in 1998. The
Company's  Board  of  Directors  has  an  Audit  Committee  and  a  Compensation
Committee.  The  Audit  Committee's  functions  include  making  recommendations
concerning the engagement of independent public accountants,  reviewing with the
independent public accountants the plan and results of the auditing  engagement,
approving  professional  services provided by the independent public accountants
and reviewing the adequacy of the Company's internal  accounting  controls.  The
Compensation Committee makes recommendations concerning compensation,  including
incentive  arrangements,  for the Company's officers. The Compensation Committee
also  administers the Company's  Amended and Restated 1989 Stock Option Plan and
will  administer  the  Company's  1998  Stock  Option  Plan if  approved  by the
Company's stockholders at the Annual Meeting.

         During  1997,  the Audit  Committee  met one time and the  Compensation
Committee met four times. During 1997, no director of the Company attended fewer
than 75 percent  of the number of  meetings  of  committees  on which he served,
except for one audit Committee  member,  Geoffrey F. Cox, who did not attend the
Audit Committee meeting.




                                                        -5-

<PAGE>



                               PROPOSAL NUMBER 2:
            APPROVAL AND ADOPTION OF THE ARONEX PHARMACEUTICALS, INC.
                             1998 STOCK OPTION PLAN

General

         The  Company  uses  stock-based   awards  as  a  part  of  its  overall
compensation  program in order to align the long-term interests of its employees
with those of its stockholders.  The Company presently maintains the Amended and
Restated 1989 Stock Option Plan under which employees,  consultants and advisors
of the Company are eligible to receive  grants of stock  options and  restricted
stock.  As of March 19,  1998,  however,  the Company had granted or proposed to
grant  stock  options  and  restricted  stock in excess of the  number of shares
authorized under the Amended and Restated 1989 Stock Option Plan.

         Accordingly, on March 19, 1998, the Compensation Committee approved the
establishment  of a new stock option plan under which options will be granted to
employees,  consultants and advisors of the Company.  The 1998 Stock Option Plan
(the  "1998  Plan")  was  subsequently  approved  and  adopted  by the  Board of
Directors on March 19, 1998, subject to approval by the Company's  stockholders.
The 1998 Plan  authorizes  the grant of options  ("Options")  to  purchase up to
750,000  shares of Common  Stock,  of which  Options to purchase an aggregate of
400,000  shares have been granted  subject to  stockholder  approval of the 1998
Plan. The terms of the 1998 Plan are  summarized  below.  In addition,  the full
text of the 1998 Plan is set forth in  Exhibit A to this  Proxy  Statement.  The
following  summary is  qualified in its entirety by reference to the text of the
1998 Plan.

Summary of the 1998 Plan

         Purpose.  The purpose of the 1998 Plan is to advance the best interests
of the Company and its  stockholders by providing those  employees,  consultants
and  advisors  of the  Company  who  have  substantial  responsibility  for  the
management  and  growth  of  the  Company  with  additional  incentives  and  an
opportunity  to obtain or increase  their  proprietary  interest in the Company,
thereby encouraging them to continue in the employ of the Company.

         Effective Date of 1998 Plan. The 1998 Plan became effective as of March
19, 1998, subject to stockholder  approval at the Annual Meeting.  No Option may
be granted pursuant to the 1998 Plan after March 19, 2008.

         Eligibility.  The  individuals  who will be eligible to receive Options
will  be  those  employees,  consultants  and  advisors  of the  Company  as the
Compensation  Committee may determine  from time to time.  The maximum number of
shares  subject to  Options  which may be issued to any person who is granted an
Option  under  the  1998  Plan  (an  "Optionee")  during  any  period  of  three
consecutive years is 250,000 shares.

         Reserved  Shares.  The total  number of  shares  of Common  Stock  with
respect to which Options may be granted under the 1998 Plan is 750,000 shares of
Common Stock.  The shares reserved for issuance upon the exercise of Options may
be treasury shares or authorized but unissued shares.

         Administration.  To comply with  Section  162(m) of the Code,  the 1998
Plan will be administered by the Compensation Committee, which will be comprised
solely of two or more Directors who are "outside  directors"  within the meaning
of the Treasury  Regulations  promulgated  under Section  162(m) of the Internal
Revenue Code of 1986, as amended (the "Code").  To comply with the  requirements
of Rule 16b-3 of the Securities  Exchange Act of 1934, as amended (the "Exchange
Act"), the 1998 Plan provides that the Compensation  Committee will be comprised
solely of two or more  Directors  who are  "non-employee  directors"  within the
meaning of Rule 16b-3.  All questions of  interpretation  and application of the
1998 Plan and Options will be subject to the  determination  of the Compensation
Committee.  The 1998 Plan will be administered in such a manner as to permit the
Options granted under it which are designated to be Incentive Options to qualify
as Incentive  Options.  The  Compensation  Committee  has complete  authority to
construe,  interpret  and  administer  provisions of the 1998 Plan, to determine
which persons are to be granted

                                                        -6-

<PAGE>



Options,   the  terms  and  conditions  of  Options,   and  to  make  all  other
determinations  necessary or deemed advisable in the  administration of the 1998
Plan.

         Incentive  Options and Nonqualified  Options.  The 1998 Plan authorizes
the grant of "Incentive  Options" (any Option  granted under the 1998 Plan which
is designated as an "Incentive Option" and satisfies the requirements of Section
422 of the Code)  and"Nonqualified  Options" (any Option  granted under the 1998
Plan other than an  Incentive  Option).  To the extent that the  aggregate  fair
market value  (determined as of the time an Incentive  Option is granted) of the
Common Stock with respect to which Incentive Options first become exercisable by
an  Optionee  during  any  calendar  year  (under  the 1998  Plan and any  other
incentive  stock  option  plan(s)  of  the  Company  or any  affiliate)  exceeds
$100,000,   the  Incentive   Options  of  such  Optionees  will  be  treated  as
Nonqualified  Options. In making this  determination,  Incentive Options will be
taken into account in the order in which they were granted.

         Exercise Price. The 1998 Plan provides that the exercise price at which
Common Stock may be purchased  under an Option will not be less than 100% of the
fair market  value of the Common Stock on the date of grant,  and provided  that
the exercise  price at which  shares of Common  Stock may be purchased  under an
Incentive Option granted to any 10% holder of Common Stock will not be less than
110% of the fair  market  value of the  Common  Stock on the date the  Incentive
Option is granted.

         Exercise  of  Options  and  Amount  Exercisable.  Each  Option  may  be
exercised  from time to time,  in whole or in part, in the manner and subject to
the conditions the Compensation Committee,  in its sole discretion,  may provide
in the written option agreement, as long as the Option is valid and outstanding.
The  exercise  price  must be paid in  full  in cash at the  time an  Option  is
exercised  or,  if  permitted  by the  Compensation  Committee,  by  means  of a
"cashless exercise" through a broker, by tendering Common Stock already owned by
the participant, or any combination of the foregoing. The Compensation Committee
will determine the period over which individual Options become exercisable.

         Expiration or Earlier  Termination  of Options.  The 1998 Plan provides
that no Option may be exercisable after the expiration of 10 years from the date
the Option is granted,  and that no Incentive  Option granted to a 10% holder of
Common Stock shall be  exercisable  after the  expiration of five years from the
date the Incentive Option is granted.
Unless otherwise provided by the Compensation Committee:

                  (a) Upon the termination of the employment or engagement of an
         Optionee by the Company  for any reason  other than cause,  disability,
         the  voluntary  retirement  of the  Optionee  in  accordance  with  the
         Company's  retirement  policy  as then in  effect  or the  death of the
         Optionee: (i) Options granted to such Optionee, to the extent that they
         were  exercisable  at  the  time  of  such  termination,  shall  remain
         exercisable until the expiration of 90 days after such termination,  on
         which  date  they  shall  expire,  and  (ii)  Options  granted  to such
         Optionee,  to the extent that they were not  exercisable at the time of
         such termination,  shall expire at the close of business on the date of
         such termination.

                  (b) Upon the termination of the employment or engagement of an
         Optionee by the  Company on account of the  disability,  the  voluntary
         retirement of the Optionee in accordance with the Company's  retirement
         policy  as then in effect or the  death of the  Optionee:  (i)  Options
         granted to such Optionee,  to the extent that they were  exercisable at
         the  time of such  termination,  shall  remain  exercisable  until  the
         expiration of one year after such termination, on which date they shall
         expire,  and (ii) Options granted to such Optionee,  to the extent that
         they were not exercisable at the time of such termination, shall expire
         at the close of business on the date of such termination.

                  (c) If an  Optionee's  employment  or engagement is terminated
         for Cause,  all  outstanding  Options  granted to such  Optionee  shall
         expire at the commencement of business on the date of such termination.

 Notwithstanding  the  foregoing,  no  Option  shall be  exercisable  after  the
expiration of its term.


                                                        -7-

<PAGE>



         Non-Transferability and No Rights as Stockholder.  Options shall not be
transferable by the Optionee otherwise than by will or under the laws of descent
and distribution and shall be exercisable,  during the Optionee's lifetime, only
by him. No Optionee will have any rights as a stockholder with respect to Common
Stock  covered by any Option held by him until the date a stock  certificate  is
issued for the Common Stock acquired on exercise of an Option.

         Changes in the Company's Capital  Structure.  In the event of any stock
dividend,  recapitalization,  reorganization,  merger,  consolidation  or  other
extraordinary  event,  the  Compensation  Committee  may,  to the extent  deemed
necessary to preserve the  benefits  under the 1998 Plan,  adjust the number and
kind of shares which  thereafter may be made the subject of Options,  the number
and kind of shares subject to outstanding  Options,  and the grant,  exercise or
conversion   price  with  respect  to  any  of  the  foregoing  and,  if  deemed
appropriate,  make  provision  for cash  payments  to  participants.  Subject to
certain  limitations,  the Board of Directors is authorized to amend, suspend or
terminate  the 1998 Plan to meet any  changes in legal  requirements  or for any
other purpose permitted by law.

         Changes of Control. In the event of a change of control of the Company,
the  Compensation  Committee  may, in its  discretion,  at the time an Option is
granted or any time  thereafter:(i)  provide  for the  acceleration  of any time
period relating to the exercise of the Option,  (ii) provide for the purchase of
the Option upon the  Optionee's  request for an amount of cash or other property
that could have been  received  upon the  exercise  of the Option had the Option
been then  currently  exercisable,  (iii)  adjust  the terms of the  Option in a
manner  determined  by the  Compensation  Committee  to  reflect  the  change of
control,  (iv)  cause  the  Option  to be  assumed,  or new  rights  substituted
therefore,  by  another  entity,  or  (v)  make  such  other  provisions  as the
Compensation  Committee  may consider  equitable and in the best interest of the
Company.

         Amendment or  Termination  of the 1998 Plan.  The Board of Directors of
the Company may amend,  terminate  or suspend the 1998 Plan at any time,  in its
sole and absolute discretion;  provided, however, that to the extent required to
maintain the status of any  Incentive  Option under the Code,  the Board may not
approve any amendment  that would (i) change the  aggregate  number of shares of
Common Stock which may be issued under Incentive Options,  (ii) change the class
of  employees  eligible to receive  Incentive  Options,  or (iii)  decrease  the
exercise  price for Incentive  Options below the fair market value of the Common
Stock  at the  time  it is  granted,  without  the  approval  of  the  Company's
stockholders.

         Tax  Withholding.  The  Company  shall be entitled to deduct from other
compensation  payable to each Optionee any sums required by federal,  state,  or
local tax law to be withheld with respect to the grant or exercise of an Option.
In the  alternative,  the  Company may require  the  Optionee  (or other  person
exercising  the Option) to pay the sum directly to the Company.  If the Optionee
(or other  person  exercising  the Option) is required to pay the sum  directly,
payment in cash or by check of such sums for taxes shall be delivered within ten
days after the date of exercise or lapse of restrictions. The Company shall have
no  obligation  upon  exercise of any Option  until  payment has been  received,
unless withholding (or offset against a cash payment) as of or prior to the date
of exercise is sufficient  to cover all sums due with respect to that  exercise.
The Company shall not be obligated to advise an Optionee of the existence of the
tax or the amount which the employer corporation will be required to withhold.

         Tax  Treatment of the Optionee.  The Optionee will  recognize no income
upon the grant of an  Incentive  Option and will  generally  incur no tax on its
exercise,  subject to the alternative minimum tax provisions of the Code. If the
Optionee  holds the stock  acquired  upon  exercise of an Incentive  Option (the
"Incentive  Option Shares") for more than one year after the date the option was
exercised and for more than two years after the date the option was granted, the
Optionee  generally  will  realize  long-term  capital gain or loss (rather than
ordinary income or loss) upon disposition of the Incentive  Option Shares.  This
gain or loss will be equal to the  difference  between the amount  realized upon
such disposition and the amount paid for the shares.

         The  Optionee  will not  recognize  any  taxable  income  at the time a
Nonqualified Option is granted. However, upon exercise of a Nonqualified Option,
the  Optionee  will  include in income as  compensation  an amount  equal to the
difference  between the fair market  value of the shares on the date of exercise
and the amount paid for that stock upon exercise of the Nonqualified Option. The
included amount will be treated as ordinary income by the Optionee and will

                                                        -8-

<PAGE>



be subject to income tax  withholding by the Company  (either by payment in cash
by the Optionee or withholding from the Optionee's  salary).  Upon resale of the
shares by the Optionee, any subsequent appreciation or depreciation in the value
of the shares will be treated as capital gain or loss.

         Tax  Treatment  of the  Company.  The  Company  will be  entitled  to a
deduction in connection with the exercise of a Nonqualified Option by a domestic
Optionee to the extent that the Optionee recognizes ordinary income. The Company
will be entitled to a deduction in connection  with the disposition of Incentive
Option Shares only to the extent that the Optionee recognizes ordinary income on
a disqualifying disposition of the Incentive Option Shares.

Option Grants under 1998 Plan

         The  following  table sets  forth the number of shares of Common  Stock
subject to, and the exercise  prices of,  options  granted  under the 1998 Plan,
which  are  subject  to  stockholder  approval  of the 1998  Plan at the  Annual
Meeting.

                                                 New Plan Benefits
<TABLE>

<CAPTION>
                                                              Number of                    Exercise Price
                         Name                            Options Granted(2)                  Per Share
<S>                                                             <C>                            <C>  
David S. Gordon, M.D...................................         80,000                         $3.88
Paul A. Cossum, Ph.D...................................         80,000                         $3.88
Praveen Tyle, Ph.D.....................................         80,000                         $3.88
Terance A. Murnane.....................................         80,000                         $3.88
                                                        --------------
Total(1)...............................................        320,000
                                                        ==============
</TABLE>
- ---------------------------

     (1) No executive  officer  other than those listed above or other  employee
has been granted options under the 1998 Plan. 

     (2) Except as otherwise  indicated,  represents  options to purchase 80,000
shares of Common Stock granted to certain executive  officers other than Dr. Cox
on March 19, 1998 at an exercise price of $3.88 per share,  which exercise price
was equal to the fair market value of the Common Stock on the date of grant.  As
of April 15, 1998,  the closing  sales price of the  Company's  Common Stock was
$3.13, as reported by The Nasdaq  National Stock Market.  The options granted to
each individual are subject to the following vesting provisions:

                  (i) Each option vests and becomes  exercisable with respect to
         10,000  shares of Common Stock if the Common  Stock  reaches or exceeds
         the stock  price  target  specified  for a given year  (based  upon the
         average  closing price per share of the  Company's  Common Stock during
         any period of 30 consecutive days within that year) until it has vested
         and become  exercisable  with respect to an aggregate of 40,000 shares.
         The stock  price  targets  for the first five years of the  options are
         $10.00 for 1998, $15.00 for 1999, $20.00 for 2000, $30.00 for 2001, and
         $38.00 for 2002;

                  (ii) Each option vests and becomes exercisable with respect to
         5,000  shares of Common Stock in each of the years 1998 through 2002 if
         the optionee  achieves  personal goals established for that year by the
         Compensation Committee;

                  (iii) Each option vests and becomes  exercisable  with respect
         to 5,000  shares of Common Stock in each of the years 1998 through 2002
         if the Company  achieves  corporate goals  established for that year by
         the Compensation Committee; and

                  (iv) Each option vests and becomes exercisable with respect to
         all of the shares not  theretofore  vested on  January  18,  2008 (nine
         years  and  ten  months  following  the  grant  date),  subject  to the
         optionee's continued employment with the Company.


     The Board of Directors recommends that stockholders vote "FOR" the approval
and adoption of the Aronex Pharmaceuticals, Inc. 1998 Stock Option Plan.

                                                        -9-

<PAGE>



                               PROPOSAL NUMBER 3:
           RATIFICATION AND APPROVAL OF INDEPENDENT PUBLIC ACCOUNTANTS

     The Board of Directors has appointed the firm of Arthur Andersen LLP as the
Company's  independent public accountants to make an examination of the accounts
of the  Company  for the  fiscal  year  ending  December  31,  1998,  subject to
ratification by the Company's  stockholders.  Representatives of Arthur Andersen
LLP will be present at the Annual Meeting and will have an opportunity to make a
statement,  if they desire to do so. They will also be  available  to respond to
appropriate questions from stockholders attending the Annual Meeting.

     The Board of Directors recommends that stockholders vote "FOR" ratification
and  approval  of the  appointment  of  Arthur  Andersen  LLP  as the  Company's
independent  public accountants for the fiscal year ended December 31, 1998, and
Proxies executed and returned will be so voted unless contrary  instructions are
indicated thereon.



                                                       -10-

<PAGE>



         REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS

     The Compensation  Committee (the  "Committee") of the Board of Directors of
the Company currently  consists of Martin P. Sutter and Gregory F. Zaic, neither
of whom are officers or employees of the Company.  The Committee is  responsible
for evaluating the performance of management,  determining the  compensation for
certain  executive  officers  of the  Company and  administering  the  Company's
Amended and Restated 1989 Stock Option Plan (the  "Employee  Option Plan") under
which grants may be made to employees,  consultants and advisors of the Company.
The  Committee  will also  administer  the 1998 Plan,  if it is  approved by the
Company's  stockholders.  The Committee  has  furnished the following  report on
executive compensation for 1997:

     Under the  supervision  of the  Committee,  the  Company  has  developed  a
compensation  policy  which is  designed  to attract  and retain key  executives
responsible  for the success of the Company and motivate  management  to enhance
long-term  stockholder  value.  The annual  compensation  package for  executive
officers   primarily   consists  of  (i)  a  cash  salary  which   reflects  the
responsibilities  relating to the  position  and  individual  performance,  (ii)
variable   performance  awards  payable  in  cash  or  stock  and  tied  to  the
individual's  or the Company's  achievement  of certain goals or milestones  and
(iii) long-term  stock-based  incentive awards which strengthen the mutuality of
interests between the executive officers and the Company's stockholders.

     In determining  the level and  composition of  compensation  of each of the
Company's  executive   officers,   the  Committee  takes  into  account  various
qualitative and quantitative indicators of corporate and individual performance.
Although no specific target has been established,  the Committee generally seeks
to set salaries  comparable  to those of peer group  companies.  In setting such
salaries,  the Committee considers its peer group to be certain companies in the
biotechnology  industry  with  market  capitalizations  similar  to  that of the
Company.  Such  comparative  group does not  necessarily  include the  companies
comprising the Nasdaq Pharmaceutical Index reflected in the performance graph in
this Proxy Statement,  which is the industry categorization the Company has been
placed  in by its  investment  bankers.  Because  the  Company  is  still in the
development stage, the use of certain traditional  performance  standards (e.g.,
profitability  and return on equity) is not currently  appropriate in evaluating
the performance of the Company's executive officers. Consequently, in evaluating
the  performance  of management,  the Committee  takes into  consideration  such
factors as the  Company's  achievement  of specified  milestones or goals in its
clinical development programs. In addition, the Committee recognizes performance
and  achievements  that are more  difficult to quantify,  such as the successful
supervision of major corporate  projects,  demonstrated  leadership  ability and
contributions to the industry and community development. For 1997, the Committee
included  in its  evaluation  the  significant  progress  made  by the  Company,
including the continuing  advancement of the Company's  clinical  development of
its products.

     Base compensation is established  through  negotiation  between the Company
and the  executive  officer  at the  time  the  executive  is  hired,  and  then
subsequently adjusted when such officer's base compensation is subject to review
or  reconsideration.  While the Company has entered into  employment  agreements
with its executive  officers,  such agreements  provide that base salaries after
the  initial  year  will be  determined  by the  Committee  after  review.  When
establishing or reviewing base compensation  levels for each executive  officer,
the Committee,  in accordance with its general  compensation  policy,  considers
numerous factors,  including the responsibilities  relating to the position, the
qualifications  of the  executive  and the relevant  experience  the  individual
brings  to  the  Company,   strategic   goals  for  which  the   executive   has
responsibility,  and  compensation  levels of companies at a comparable stage of
development who compete with the Company for business, scientific, and executive
talents.  No  pre-determined  weights are given to any one of such factors.  The
Committee believes that the base salaries for the executive officers  generally,
and the Chief Executive Officer specifically, for fiscal 1997 were comparable to
the Company's peer group companies.

     In addition to each executive  officer's base  compensation,  the Committee
may award cash bonuses and/or grant awards under the Company's  employee  option
plans to chosen  executive  officers  depending  on the extent to which  certain
defined personal and corporate  performance  goals are achieved.  Such corporate
performance goals are the same as discussed above.


                                                       -11-

<PAGE>



     All  employees  of the  Company,  including  its  executive  officers,  are
eligible to receive long-term  stock-based  incentive awards under the Company's
employee option plans as a means of providing such individuals with a continuing
proprietary  interest in the  Company.  Such grants  further  the  mutuality  of
interest  between the  Company's  employees  and its  stockholders  by providing
significant incentives for such employees to achieve and maintain high levels of
performance.  The Company's  employee option plans enhance the Company's ability
to attract and retain the services of qualified individuals.  Factors considered
in  determining  whether such awards are granted to an executive  officer of the
Company include the executive's  position in the Company, his or her performance
and responsibilities, the amount of stock options, if any, currently held by the
officer,  the vesting schedules of any such options and the executive  officer's
other  compensation.   While  the  Committee  does  not  adhere  to  any  firmly
established  formulas or schedules for the issuance of awards such as options or
restricted  stock,  the Committee  will  generally  tailor the terms of any such
grant to achieve  its goal as a long-term  incentive  award by  providing  for a
vesting  schedule  encompassing  several  years or tying  the  vesting  dates to
specific corporate or personal milestones.

Compensation of Chief Executive Officer

     Geoffrey F. Cox,  Ph.D.  became the Company's  Chief  Executive  Officer in
November  1997.  His base  annual  salary was set at  $300,000  pursuant  to his
employment  agreement  with  the  Company,   effective  November  3,  1997  (the
"Employment  Agreement").  In setting  this initial base salary for Dr. Cox, the
Committee  evaluated the  compensation  package for chief executive  officers of
peer group  biotechnology  companies  with similar market  capitalizations.  The
Committee  expects that when it  reevaluates  Dr. Cox's base salary level in the
future,   it  will   consider  a  variety  of  factors,   including   Dr.  Cox's
responsibilities,  his general background and qualifications, his achievement of
various  corporate and personal  milestones  set by the  Committee  from time to
time, and compensation  levels for executives in Dr. Cox's position and with his
background  at  peer  group  companies.  The  Committee  has  not  attached  any
particular  relative  weighting to the  foregoing  factors (or any other factors
which the Committee may also consider in reaching compensation decisions for the
Company's executive officers).

     Dr. Cox received a sign-on bonus of $220,000, $110,000 of which was paid to
him in cash.  He received the  remaining  $110,000 as a  restricted  stock award
under the Employee  Option Plan,  and  accordingly,  received  17,278  shares of
Common  Stock,  which grant was  calculated  based on the average  closing sales
price of the Company's Common Stock for the thirty-day period preceding November
3, 1997,  $5.44 per share.  Under the terms of Dr. Cox's  Employment  Agreement,
these shares were fully vested on the date of grant.  The  Employment  Agreement
provides that Dr. Cox is eligible to receive future incentive bonus awards in an
amount up to 33% of his base annual salary. The Committee will retain discretion
to determine the amount of any future  incentive  bonus awards to be paid to Dr.
Cox,  and the  Committee  expects  that it will  evaluate a number of factors in
reaching this decision,  including the Company's  strategic  goals for which Dr.
Cox  has  responsibility,  his  other  responsibilities,   his  initiatives  and
contributions  to the Company's  achievement of various  corporate and strategic
goals, and his own achievement of certain  personal  milestones as determined by
the Committee from time to time.

     Dr. Cox was  granted a stock  option to purchase  500,000  shares of Common
Stock at an exercise price of $4.25 per share.  This option grant was negotiated
by the Company and Dr. Cox as part of the Employment  Agreement and the exercise
price  was the  fair  market  value  of the  Company's  stock  specified  in the
Employment Agreement, which was September 3, 1997 the date of a letter agreement
pursuant  to which Dr.  Cox agreed to enter into  employment  with the  Company.
Twenty percent of the underlying shares vested on the date of grant, and as long
as he continues  in the employ of the  Company,  Dr. Cox will be vested in 8,333
shares per month for the remaining 80% of the stock option grant.  The Committee
expects that Dr. Cox will  participate  in the Employee  Option Plan on the same
general  terms as other  participants  in the Plan with  respect to future stock
option  grants that he may be granted from time to time,  although the amount of
shares underlying  option grants to Dr. Cox will be potentially  larger than for
other employees as a result of his position.

     The Employment  Agreement  also provides that for the next four years,  Dr.
Cox will be  eligible  to receive  an annual  restricted  stock  grant of 25,000
shares of Common Stock if certain  stock price  objectives  are achieved  during
such fiscal years. The Employment Agreement  contemplates that these shares will
be fully-vested on issuance.

                                                       -12-

<PAGE>



     The Company paid its former president,  James M. Chubb, Ph.D.,  $235,000 in
annual base salary during 1997.  Dr.  Chubb's  initial base salary was $212,000,
which salary was increased to $235,000 in 1996. The Committee based its decision
to increase  Dr.  Chubb's  salary on a  combination  of factors,  including  Dr.
Chubb's  responsibilities  as the Company's  president,  the corporate goals for
which he had  responsibility,  his  contribution  to the  achievement of certain
corporate  and personal  milestones,  and the base salary paid to  presidents of
comparable peer group companies.

     Dr.  Chubb  received a cash bonus of  $58,750  for 1997.  The amount of Dr.
Chubb's 1997 bonus was based on the  Company's  achievements  in  advancing  the
clinical  development  of its  lead  products  and Dr.  Chubb's  achievement  of
personal goals,  including the successful recruitment and integration of key new
management personnel. During 1997, Dr. Chubb did not receive any stock option or
restricted  stock  grants under the  Employee  Option  Plan.  Dr. Chubb left the
Company's employ in January 1998. Dr. Chubb's severance  agreement obligated the
Company to continue to pay Dr. Chubb his base annual salary of $235,000  through
January 1999. The Company also agreed to continue certain employee  benefits for
Dr. Chubb and his dependents  through  January 1999. The Committee also approved
the extension of the vesting period of, and the  exercisability  period for, all
of Dr. Chubb's outstanding stock options as part of his severance package.

     Section  162(m) of the Code,  added by the  Revenue  Reconciliation  Act of
1993, places a $1 million cap on the deductible compensation that can be paid to
certain  executives  of  publicly-traded  corporations.  Amounts that qualify as
"performance  based"  compensation  under Section  162(m)(4)(c)  of the Code are
exempt  from the cap and do not count  toward the $1 million  limit.  Generally,
stock options will qualify as performance based compensation.  The Committee has
discussed and considered  and will continue to evaluate the potential  impact of
Section 162(m) on the Company in making compensation determinations, but has not
established a set policy with respect to future compensation determinations.

     The foregoing report is given by the following  members of the Compensation
Committee:


                                Martin P. Sutter
                                Gregory F. Zaic

     The report of the Compensation  Committee shall not be deemed  incorporated
by  reference by any general  statement  incorporating  by reference  this Proxy
Statement into any filing under the Securities Act of 1933, as amended, or under
the  Exchange  Act,   except  to  the  extent  that  the  Company   specifically
incorporates  this  information by reference,  and shall not otherwise be deemed
filed under such Acts.




                                                       -13-

<PAGE>



                             EXECUTIVE COMPENSATION

Executive Officers

     Set forth below is certain information concerning the executive officers of
the  Company,  including  the business  experience  of each during the past five
years.
<TABLE>


<CAPTION>
                   Name                            Age                        Position with the Company
                   ----                            ---                        -------------------------
<S>                                                <C>        <C>                                                 
Geoffrey F. Cox, Ph.D......................        54         Chairman of the Board of Directors (Class II) and
                                                              Chief Executive Officer
David S. Gordon, M.D.......................        56         Senior Vice President of Medical Affairs and Chief
                                                              Medical Officer
Paul A. Cossum, Ph.D.......................        45         Vice President, Preclinical Development
Praveen Tyle, Ph.D.........................        38         Vice President, Pharmaceutical Development and
                                                              Operations
Janet M. Walter............................        35         Vice President, Marketing and Business Development
Terance A. Murnane.........................        47         Controller and Secretary
</TABLE>

     Information regarding the business experience of Dr. Cox is set forth above
under the heading "Current and Continuing Directors."

     David S. Gordon,  M.D.  joined the Company in April 1997 as its Senior Vice
President of Medical Affairs and Chief Medical  Officer.  Dr. Gordon has over 20
years  experience  in  internal  medicine,  oncology  and  hematology,  clinical
research   and  the   pharmaceutical   industry.   He  has  held   clinical  and
administrative   positions  with  The  Liposome   Company  and  the  RW  Johnson
Pharmaceutical  Research  Institute of Johnson & Johnson.  Prior to positions in
the  pharmaceutical  industry,  Dr. Gordon held a number of academic  positions,
including  Professor of Medicine  (Hematology  & Oncology)  at Emory  University
School of  Medicine  and  Director,  Division of  Immunology  at the Centers for
Disease  Control,  both in  Atlanta,  Georgia.  He serves as a director of Hycor
Biomedical,  Inc. Dr. Gordon is board certified in Internal Medicine and Medical
Oncology.  He has  published  over 100 articles  and  abstracts in the fields of
cancer, infectious disease and immunology.

     Paul  A.  Cossum,   Ph.D.   joined  Triplex   Pharmaceuticals   Corporation
("Triplex") as Vice President of Preclinical Development in 1993 and assumed the
position  of  Vice  President  of  Preclinical  Development  of the  Company  in
September 1995 upon the  consummation of the Company's  mergers with Triplex and
Oncologix,  Inc.  From  1992  to  1993,  he  was  the  Director  of  Preclinical
Development at Isis Pharmaceuticals.  While at Isis, he implemented  preclinical
programs to support the  development of  Investigational  New Drug  Applications
("INDs") for two anti-viral  oligonucleotide  compounds. Prior to his employment
at Isis,  Dr. Cossum worked in the  Department  of  Pharmacological  Sciences at
Genentech,  Inc.,  where he  participated  in the filing of several INDs and New
Drug Applications ("NDAs") for certain endocrine,  cardiovascular and neurologic
therapeutic  proteins.  He has published  widely in the fields of metabolism and
toxicology of oligonucleotides, recombinant proteins and conventional drugs.

     Praveen  Tyle,  Ph.D.  joined  the  Company  in  February  1997 as its Vice
President of Pharmaceutical  Development and Operations.  Dr. Tyle has more than
14 years of worldwide pharmaceutical industry experience,  serving most recently
as Senior Director, Pharmaceutical Development at Agouron Pharmaceuticals, Inc.,
where  he was  responsible  for the  development  of  preclinical  and  clinical
products and their preparation toward commercialization.  From 1984 to 1991, Dr.
Tyle held  product  development  positions  at  American  Cyanamid  Company  and
Novartis  (formerly Sandoz  Pharmaceuticals  Corporation).  Dr. Tyle serves as a
member  of the  Scientific  Advisory  Board of a French  biotechnology  company,
Biovector  Therapeutics,  S.A., and is a scientific  advisor to Warner  Chilcott
Laboratories  in New Jersey.  Dr. Tyle also  serves as an adjunct  Professor  of
Pharmaceutical  Sciences at the  University  of Houston.  He holds  several U.S.
patents in the areas of drug development and delivery systems.

     Janet M.  Walter  joined  the  Company  in August  1997 as Vice  President,
Marketing and Business  Development.  Ms. Walter, who has more than ten years of
oncology marketing experience, served most recently as Director, Global
                                                       -14-

<PAGE>



Marketing at Schering-Plough Pharmaceuticals, Inc. where she was responsible for
the  worldwide  development  of  INTRON(R)A.  She also served as Senior  Product
Manager for Bristol-Myers  Squibb Oncology  Division,  where she was responsible
for the launch of TAXOL(R) in several different markets,  and Product Manager at
US Bioscience.  In addition, Ms. Walter has several years of prior experience in
oncology clinical research and field sales.

     Terance A. Murnane joined the Company in May 1990 as its Controller and was
appointed Secretary in January 1992. Mr. Murnane was a self-employed  accountant
from  February  1988 until April 1990.  From October 1987 to February  1988,  he
served as the Controller for a privately-held  wholesale company.  Prior to that
time, he spent ten years in the Private  Business/Audit  Department at KPMG Peat
Marwick,  an  international  accounting  firm,  serving most  recently as Senior
Manager. Mr. Murnane is a Certified Public Accountant.

Compensation of Executive Officers

     Summary Compensation Table

     The  following  table  provides  certain  summary  information   concerning
compensation  paid or accrued during the last three years to the Company's Chief
Executive  Officer,  to its former  President and to each of the other executive
officers of the Company, determined as of the end of the last fiscal year, whose
annual compensation exceeded $100,000 (the "Named Executive Officers"):
<TABLE>
<CAPTION>

                                                                                          Long-Term
                                                 Annual Compensation                     Compensation
                                                                                  Restricted      Securities
                                                                                     Stock      Underlying         All Other
      Name and Principal Position        Year        Salary          Bonus          Awards        Options (#)    Compensation
- -------------------------------------- -------- ---------------- -------------  --------------  -----------------------------
<S>                                      <C>    <C>              <C>            <C>              <C>          <C>         
Geoffrey F. Cox, Ph.D.................   1997   $   50,000(1)    $ 110,000(2)    $  93,992(3)     500,000      $     134(4)
   Chief Executive Officer
David S. Gordon, M.D..................   1997   $  146,208(5)    $  28,400             --         125,000      $  21,360(6)
   Senior Vice President of Medical
   Affairs and Chief Medical Officer
Paul A. Cossum, Ph.D..................   1997   $  168,000       $  33,600             --          41,000      $   1,302(8)
   Vice President, Preclinical           1996   $  163,000       $   2,000             --          44,800      $   1,292(8)
   Development                           1995   $   46,667(7)           --             --          20,000      $  17,000(9)
Praveen Tyle, Ph.D....................   1997   $  147,377(10)   $  30,100      $   36,250(11)    125,000      $  77,956(12)
   Vice President, Pharmaceutical
   Development and Operations
Janet M. Walter.......................   1997   $   60,000(13)   $  12,000             --         100,000      $   8,974(14)
   Vice President, Marketing and
   Business Development
James M. Chubb, Ph.D..................   1997   $  235,000       $  58,750                            --       $   8,339(15)
   Former President                      1996   $  221,583       $  10,000             --         208,000      $  32,389(16)
                                         1995   $   61,833(17)          --      $  106,250(18)    125,000      $  42,075(19)
</TABLE>
- ---------------------------

(1)  Dr. Cox joined the Company as Chief  Executive  Officer and Chairman of the
     Board in November 1997 at an annual base salary of $300,000.
(2)  Represents a cash bonus paid upon commencement of employment.
(3)  Represents  a stock  bonus of 17,278  shares of Common  Stock  issued  upon
     commencement of employment and recorded at fair market value at the time of
     issuance.
(4)  Represents taxable life insurance.
(5)  Dr. Gordon joined the Company as Senior Vice  President of Medical  Affairs
     and  Chief  Medical  Officer  in April  1997 at an  annual  base  salary of
     $213,000.
(6)  Represents  (i)  $6,952  in  relocation  costs,  (ii)  $12,250  in  housing
     allowance,  (iii)  $1,158 in  taxable  life  insurance  and (iv)  $1,000 in
     matching contributions to the Company's 401(k) savings plan. 
(7)  Dr. Cossum joined the Company as Vice President of Preclinical  Development
     in  September  1995 at an annual  base  salary of  $160,000.  Dr.  Cossum's
     current annual base salary is $168,000.
(8)  Represents  (i) $1,000 in matching
     contributions  to the  Company's  401(k)  savings  plan in 1996  and  1997,
     respectively,  and (ii) taxable life insurance of $292 and $302 in 1996 and
     1997,  respectively.  
(9)  Represents  the  forgiveness of a portion of the
     balance of a loan to Dr.  Cossum.  
(10) Dr. Tyle joined the Company as Vice
     President of Pharmaceutical  Development and Operations in February 1997 at
     an annual base salary of $168,000. Dr. Tyle's current annual base salary is
     $176,400.

                                                        -15-

<PAGE>



(11) Represents  a stock  bonus of 5,000  shares of  Common  Stock  issued  upon
     commencement of employment and recorded at fair market value at the time of
     issuance.

(12) Represents  (i) $46,386 in  relocation  costs,  (ii)  $30,397 in  estimated
     federal  income  taxes  relating  to  such  relocation  costs,   which  are
     reimbursable  by the Company in 1998,  (iii) $173 in taxable life insurance
     and (iv) $1,000 in matching  contributions  to the Company's 401(k) savings
     plan. 
(13) Janet M. Walter joined the Company as Vice President,  Marketing
     and  Business  Development  in  August  1997 at an  annual  base  salary of
     $160,000.  
(14)  Represents  (i) $7,924 in  relocation  costs,  (ii) $50 in
     taxable life  insurance and (iii) $1,000 in matching  contributions  to the
     Company's  401(k) savings plan.  
(15) Represents (i) $7,339 in taxable life
     and   long-term   disability   insurance   and  (ii)   $1,000  in  matching
     contributions  to the Company's  401(k) savings plan.  
(16) Represents  (i)$25,695  in federal  income  taxes  incurred by Dr. Chubb in
     connection  with the 1996 grant of 25,000  shares of Common  Stock that the
     Company  reimbursed  in 1997,  (ii)  $5,694 in taxable  life and  long-term
     disability  insurance  and (iii)  $1,000 in matching  contributions  to the
     Company's 401(k) savings plan.
(17) Dr. Chubb  joined the Company as  President in September  1995 at an annual
     base salary of $212,000.
(18) Represents  a stock  bonus of 25,000  shares of Common  Stock  issued  upon
     commencement of employment and recorded at fair market value at the time of
     issuance.
(19) Represents  the estimated  amount of federal  income taxes  incurred by Dr.
     Chubb in  connection  with the grant of 25,000  shares of Common Stock that
     the Company reimbursed in 1996.

     Option Grants in 1997

         The  following  table  provides  certain  information  with  respect to
options  granted  to the  Chief  Executive  Officer  and to  each  of the  Named
Executive  Officers  during the fiscal  year ended  December  31, 1997 under the
Company's Employee Option Plan:

<TABLE>
<CAPTION>

                                             Individual Grants
                    Number of    Percent of                                               Potential Realizable Value at
                    Securities  Total Options                   Market                       Assumed Annual Rates of
                    Underlying   Granted to     Exercise       Price on                      Stock Price Appreciation
                      Options   Employees in    Price per       Date of     Expiration           for Option Term(1)
       Name         Granted (#)  Fiscal Year      Share          Grant         Date              5%              10%
       ----         -----------  -----------      -----          -----         ----              --              ---
<S>                  <C>            <C>       <C>           <C>             <C>   <C>    <C>              <C>           
Geoffrey F. Cox      500,000        41.3%     $    4.25     $     4.25      09/03/04     $    865,088     $    1,986,602
David S. Gordon      125,000        10.3%     $    5.13     $     5.13      04/28/04     $    261,053     $      599,486
Paul A. Cossum        31,000         2.6%     $    4.75     $     4.75      05/14/04     $     59,946     $      137,660
                      10,000         0.8%     $    4.75     $     4.75      12/09/04     $     19,337     $       44,406
Praveen Tyle         100,000         8.3%     $    7.25     $     7.25      02/21/04     $    295,148     $      677,782
                      25,000         2.1%     $    4.75     $     4.75      12/09/04     $     48,343     $      111,016
Janet M. Walter      100,000         8.3%     $    4.50     $     4.50      08/18/04     $    183,195     $      420,692
James M. Chubb            --           --            --             --         --                  --                 --
</TABLE>

(1)      The  Securities  and Exchange  Commission  requires  disclosure  of the
         potential  realizable  value  or  present  value  of  each  grant.  The
         disclosure  assumes  the options  will be held for the full  seven-year
         term prior to exercise.  Such options may be exercised prior to the end
         of such seven-year term. The actual value, if any, an executive officer
         may  realize  will  depend  upon the excess of the stock price over the
         exercise  price on the date the  option is  exercised.  There can be no
         assurance  that the stock price will  appreciate  at the rates shown in
         the table.

     Year-End Option Values

        The  following  table sets forth certain  information  regarding (i) the
number of shares of Common  Stock  underlying  unexercised  options  held by the
Chief  Executive  Officer and each Named  Executive  Officer as of December  31,
1997;  (ii) the value,  at December 31, 1997, of exercisable  and  unexercisable
"in-the-money"  stock options held by the Chief Executive Officer and each Named
Executive  Officer.  Neither  the Chief  Executive  Officer  nor any other Named
Executive Officer exercised any stock options during the year ended December 31,
1997.



                                                        -16-

<PAGE>


<TABLE>
<CAPTION>


                                       1997 Option Values

                                        Number of Securities            Value of Unexercised
                                       Underlying Unexercised           In-the-Money Options
                                   Options at Fiscal Year-End (#)     at Fiscal Year End ($)(1)


              Name                  Exercisable     Unexercisable    Exercisable   Unexercisable
- ---------------------------------   ------------  ---------------- -------------- --------------
<S>                                  <C>               <C>         <C>            <C>        
Geoffrey F. Cox, Ph.D............    149,155           383,345     $       --     $        --
David S. Gordon, M.D.............     42,000            83,000     $       --     $        --
Paul A. Cossum, Ph.D.............     45,306            72,489     $   42,922     $       100
Praveen Tyle, Ph.D...............     49,500            75,500     $       --     $        --
Janet M. Walter..................     35,932            64,068     $       --     $        --
James. M. Chubb, Ph.D............    158,460           199,224     $   99,514     $       548
</TABLE>

(1)       A stock option is  "in-the-money"  if the closing  market price of the
          Company's  Common  Stock  exceeds  the  exercise  price of such  stock
          option.  The value of  "in-the-money"  unexercised  stock  options set
          forth in the foregoing  table  represents the  difference  between the
          exercise  price of such  options  and the  closing  sales price of the
          Company's Common Stock on December 31, 1997, as reported by the Nasdaq
          Stock Market, $4.25 per share.

Performance Graph

         The  following  performance  graph  compares  the  performance  of  the
Company's  Common Stock to the Nasdaq Composite Index and to the Nasdaq Index of
Pharmaceutical  Companies.  The graph  covers the period from July 10, 1992 (the
date on which the Company's  Common Stock was registered  under Section 12(g) of
the Exchange Act), to December 31, 1997. The graph assumes that the value of the
investment in the Company's Common Stock and each index was 100 at July 10, 1992
and that all dividends were reinvested.

[GRAPHIC OMITTED]
<TABLE>
<CAPTION>
                                              12/31/92      12/31/93       12/31/94      12/31/95       12/31/96       12/31/97
<S>                                            <C>            <C>            <C>           <C>            <C>            <C>  
Aronex Pharmaceuticals, Inc.                   100.00        57.14          24.29         50.00          53.57          24.29
Nasdaq Composite Index                         100.00       114.79         112.21        158.69         195.18         239.57
Nasdaq Pharmaceutical Index                    100.00        89.13          67.08        122.72         123.08         127.09

</TABLE>


         The foregoing stock price  performance  comparisons shall not be deemed
incorporated by reference by any general  statement  incorporating  by reference
this  Proxy  Statement  into any filing  under the  Securities  Act of 1933,  as
amended,  or under the  Exchange  Act,  except to the  extent  that the  Company
specifically  incorporates  this graph by reference,  and shall not otherwise be
deemed filed under such acts.

         There can be no assurance  that the Company's  stock  performance  will
continue into the future with the same or similar  trends  depicted in the graph
above.  The Company will not make or endorse any  predictions as to future stock
performance.


                                                        -17-

<PAGE>



Employment Agreements

         The Company has entered into  employment  agreements  with Dr. Cox, Dr.
Gordon,  Dr. Cossum,  Dr. Tyle, Ms. Walter and Mr. Murnane which establish their
annual base salaries and provide for the payment of such bonus  compensation  as
may be  awarded by the Board of  Directors  and for their  participation  in all
employee  benefit plans sponsored by the Company.  The employment  agreement for
Dr. Cox has a primary  term  ending in 2000,  with  automatic  monthly  renewals
starting in May 1999 for an on-going eighteen months unless terminated by either
party.  All other  employment  agreements  are for a one year  period  and renew
automatically  for one year  periods  unless  terminated  by either  party.  All
agreements  provide that if the employee is terminated for any reason other than
cause,  the Company is  obligated  to pay to the employee an amount equal to one
year's annual base salary and continue the provision of employment  benefits for
one year following termination.

 401(k) Plan

         The Company maintains a retirement  savings plan,  effective as amended
on January 1, 1991,  in which any employee of the Company who has  completed one
month of employment may elect to participate.  The plan is an individual account
plan providing for deferred  compensation  as described in Section 401(k) of the
Code and is subject to, and  intended to comply with,  the  Employee  Retirement
Income Security Act of 1974, as amended.  Each eligible employee is permitted to
contribute up to 20% of his annual salary up to the applicable statutory maximum
prescribed in the Code. The Company may, in its discretion, contribute an amount
equal to the  employee's  contribution,  but such Company  contribution  may not
exceed  an  amount  equal  to six  percent  of the  employee's  compensation.  A
participant  is 50% vested in the accrued  benefits  derived from the  Company's
contributions after completion of one year of employment  following his election
to  participate  in the  plan,  and  100%  vested  in such  contributions  after
completion of two years of employment following such election.  Participants may
receive  hardship  loans  under  the terms of the plan.  The plan  provides  for
distributions  in the event a participant  dies,  reaches the age of 65, becomes
disabled or terminates his  employment  prior to the age of 65. The Company made
contributions of approximately $45,700 under the 401(k) plan in 1997.


                              CERTAIN TRANSACTIONS

         The Company has a consulting  agreement  with Gabriel  Lopez-Berestein,
M.D., whereby the Company is committed to pay annual consulting fees of $156,000
for 1998,  1999 and 2000,  one-half of which is payable in cash and  one-half of
which is payable in shares of  restricted  Common  Stock.  The Company  paid Dr.
Lopez-Berestein  $156,000 in cash under a predecessor  agreement during the year
ended December 31, 1997.



                                                        -18-

<PAGE>



         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

         The  following  table  presents  certain   information   regarding  the
beneficial  ownership of the  Company's  Common Stock as of February 28, 1998 by
(i) each person who is known by the Company to own  beneficially  more than five
percent of the  outstanding  shares of Common  Stock,  (ii) each director of the
Company, (iii) the Company's chief executive officer and each of the other Named
Executive  Officers and (iv) all directors  and  executive  officers as a group.
Except as  described  below,  each of the  persons  listed in the table has sole
voting and investment power with respect to the shares listed.
<TABLE>
<CAPTION>

                                Number of Shares
                                                              of Common Stock                Percentage of Shares
Name                                                          Beneficially Owned             Beneficially Owned

<S>                                                             <C>                                 <C> 
Paragon Associates and Paragon Associates II (1).....           1,351,000                           8.7%
   Joint Venture and the Bradbury Dyer Foundation
   500 Crescent Court, Suite 260
   Dallas, Texas 75201
Hillman Medical Venture Partnerships (2).............           1,187,925                           7.7%
   824 Market Street, Suite 900
   Wilmington, Delaware 19801
Amerindo Investment Advisors, Inc. (3)...............           1,023,750                           6.6%
   One Embarcadero Center, Suite 2300
   San Francisco, California 94111
HealthCare Ventures Partnerships (4).................             977,825                           6.3%
   Twin Towers at Metro Bank
   379 Thornall Street
   Edison, New Jersey 08837
The Allstate Corporation (5).........................             810,962                           5.2%
   2775 Sanders Road
   Northbrook, Illinois 60062
Martin P. Sutter (6).................................             550,883                           3.5%
Geoffrey F. Cox (7)..................................             200,767                           1.3%
Gabriel Lopez-Berestein (8)..........................             142,889                              *
Ronald J. Brenner (9)................................           1,238,013                           8.0%
Gregory F. Zaic (10).................................             445,239                           2.9%
James R. Butler (11).................................              30,500                              *
Paul A. Cossum (12)..................................              57,952                              *
Praveen Tyle (13)....................................              66,081                              *
David S. Gordon (14).................................              57,333                              *
Janet M. Walter (15).................................              41,800                              *
James M. Chubb (16)..................................             278,627                           1.8%
All directors and officers as a group
   (11 persons) (6)-(15).............................           2,860,415                          18.4%

- ---------------------------
</TABLE>

*      Less than one percent.

(1)  Consists of 1,331,000 shares  beneficially  owned by Paragon  Associates II
     Joint  Venture   ("Paragon  JV"),  which  includes   ownership  of  Paragon
     Associates  and  Paragon  Associates  II,  and 20,000  shares  owned by the
     Bradbury  Dyer  Foundation  ("Foundation").  The sole  general  partner  of
     Paragon  Associates and Paragon JV,  Bradbury Dyer III, may be deemed to be
     the beneficial ownership of 1,351,000 shares.
(2)  Consists of 141,232  shares owned by Hillman  Medical  Ventures  1989 L.P.,
     441,383  shares  owned by Hillman  Medical  Ventures  1990 L.P. and 605,310
     shares  owned by Hillman  Medical  Ventures  1991 L.P.  (collectively,  the
     "Hillman  Medical  Venture  Partnerships").  The  general  partners  of the
     Hillman Medical Venture Partnerships are Cashon Biomedical Associates, L.P.
     and Hillman/Dover Limited Partnership. The general partner of Hillman/Dover
     Partnership is a  wholly-owned  subsidiary of The Hillman  Company,  a firm
     engaged in diversified  investments and operations.  The Hillman Company is
     controlled  by  Henry  L.  Hillman,   Elsie   Hilliard   Hillman  and  C.G.
     Grefenstette, Trustees of the Henry L. Hillman Trust, which Trustees may be
     deemed the beneficial  owners of the 1,187,925  shares owned by the Hillman
     Medical Venture  Partnerships.  Dr. Brenner, a director of the Company,  is
     the managing partner of Cashon  Biomedical  Associates,  L.P., of which the
     other general  partners are Hal S.  Broderson,  M.D. and Charles G. Hadley.
     Dr. Brenner, Dr. Broderson and Mr. Hadley may be deemed to beneficially own
     such shares.
<PAGE>

(3)  Consists of 1,006,250 shares owned by Amerindo  Investment  Advisors,  Inc.
     ("Amerindo"),  7,500 shares  owned by Amerindo  Advisors,  Inc.  ("Amerindo
     Panama"),  and 10,000  shares owned by Amerindo  Investment  Advisors  Inc.
     Profit  Sharing  Trust  ("Plan").  The sole  shareholders  and directors of
     Amerindo and Amerindo Panama are Alberto W. Vilar and Gary A. Tanaka,  each
     of whom may by deemed to be the  beneficial  owner of the 1,013,750  shares
     owned by Amerindo  and  Amerindo  Panama.  Mr. Vilar is sole trustee of the
     Plan and may be  deemed to be the  beneficial  owner of the  10,000  shares
     owned by the Plan.  Based on Schedule 13G,  Amendment No. 3, dated February
     13, 1998, of Amerindo, Amerindo Panama, the Plan, Mr. Vilar and Mr. Tanaka.
(4)  Consists of 255,132  shares owned by HealthCare  Ventures I, L.P.,  199,391
     shares  owned by  HealthCare  Ventures II,  L.P.,  404,651  shares owned by
     HealthCare  Ventures  III,  L.P.  and 118,651  shares  owned by  HealthCare
     Ventures IV, L.P.  (collectively,  the "HealthCare Venture  Partnerships").
     James H.  Cavanaugh,  Ph.D.,  Harold R. Werner,  John W.  Littlechild,  and
     William W. Crouse are general  partners of each of the  HealthCare  Venture
     Partnerships and may be deemed to beneficially own such shares.
(5)  Consists of 810,962 shares owned by Allstate  Insurance  Company,  a wholly
     owned  subsidiary  of The  Allstate  Corporation,  based on  Schedule  13G,
     Amendment No. 5, dated February 10, 1998, of The Allstate Corporation.
(6)  Includes  463,883  shares owned by The  Woodlands  Venture  Fund,  L.P. Mr.
     Sutter is a general partner of The Woodlands Venture Partners,  L.P., which
     is the general  partner of The  Woodlands  Venture  Fund,  L.P. Mr.  Sutter
     disclaims beneficial ownership of the 463,883 shares owned by The Woodlands
     Venture Fund, L.P. Also includes 85,750 shares which may be acquired on the
     exercise of the currently vested portion of stock options.
(7)  Includes  182,489  shares  that may be  acquired  on the  exercise of stock
     options. Also includes 17,278 shares owned by Dr. Cox's spouse which may be
     considered to be beneficially owned.
(8)  Includes  65,000  shares  that may be  acquired  on the  exercise  of stock
     options.  Excludes 19,697 shares held by a relative of Dr. Lopez-Berestein,
     to which he disclaims beneficial ownership.
(9)  Includes   1,187,925   shares   owned  by  the  Hillman   Medical   Venture
     Partnerships,  of which Dr. Brenner is the managing  general partner of one
     of the general partners.  Also includes 40,000 shares which may be acquired
     on the exercise of the currently vested portion of stock options.
(10) Includes 403,539 shares owned by Prince Venture Partners III, L.P. Mr. Zaic
     is the general partner of Prince Ventures, L.P., which is a general partner
     of  Prince  Venture  Partners  III,  L.P.  Mr.  Zaic  disclaims  beneficial
     ownership of the shares held by Prince  Venture  Partners  III,  L.P.  Also
     includes  40,000  shares  which  may be  acquired  on the  exercise  of the
     currently vested portion of stock options. 
(11) Includes  25,000  shares that may be acquired on the  exercise of currently
     vested stock  options.  Also includes 3,000 shares owned through The Butler
     Living Trust and 2,500  shares owned by the spouse of Mr.  Butler which may
     be considered to be beneficially owned.
(12) Includes  52,287  shares  that  may  be  acquired  on the  exercise  of the
     currently vested portion of stock options. Also includes 1,000 shares owned
     by two daughters of Dr.  Cossum which may be considered to be  beneficially
     owned.
(13) Includes  56,967  shares  that  may  be  acquired  on the  exercise  of the
     currently vested portion of stock options.
(14) Includes  50,500  shares  that  may  be  acquired  on the  exercise  of the
     currently vested portion of stock options. Also includes 3,000 shares owned
     by Gordon  Strategic,  Inc.  which is wholly  owned by Dr.  Gordon  and 500
     shares  owned  by  Dr.  Gordon's  spouse  which  may  be  considered  to be
     beneficially owned.
(15) Represents  shares that may be acquired on the exercise of currently vested
     stock options.
(16) Includes  186,165  shares  that  may be  acquired  on the  exercise  of the
     currently vested portion of stock options.


                                                        -20-

<PAGE>



                          COMPLIANCE WITH SECTION 16(a)

     Section 16(a) of the Securities Exchange Act of 1934, as amended,  requires
the Company's  directors and officers,  and persons who own more than 10% of the
Common  Stock,  to file initial  reports of ownership  and reports of changes in
ownership  (Forms 3, 4, and 5) of Common Stock with the  Securities and Exchange
Commission (the "SEC").  Officers,  directors and greater than 10%  stockholders
are  required by SEC  regulation  to furnish the Company with copies of all such
forms that they file.

     To the Company's  knowledge,  based solely on the  Company's  review of the
copies of such reports received by the Company and on written representations by
certain reporting  persons that no reports on Form 5 were required,  the Company
believes that during the fiscal year ended  December 31, 1997, all Section 16(a)
filing requirements  applicable to its officers,  directors and 10% stockholders
were  complied  with in a timely  manner,  with the exception of late filings on
Form 4 covering two  transactions by David S. Gordon and on an amended Form 3 by
James R. Butler.

                            PROPOSAL OF STOCKHOLDERS

     Any proposal of a  stockholder  intended to be presented at the next annual
meeting must be received at the Company's  principal  executive offices no later
than February 1, 1999, if the proposal is to be considered  for inclusion in the
Company's Proxy Statement relating to such meeting.

                              FINANCIAL INFORMATION

     A copy of the Company's Annual Report on Form 10-K, including any financial
statements and schedules and exhibits thereto, may be obtained without charge by
written  request  to  Terance  A.  Murnane,  Controller  and  Secretary,  Aronex
Pharmaceuticals,  Inc.,  8707  Technology  Forest Place,  The  Woodlands,  Texas
77381-1191.


                                             By Order of the Board of Directors



                                             Terance A. Murnane
                                             Secretary


April 30, 1998
The Woodlands, Texas

                                                        -21-

<PAGE>



                                                                       EXHIBIT A
                          ARONEX PHARMACEUTICALS, INC.
                             1998 STOCK OPTION PLAN

                                    ARTICLE I

                                      PLAN

         1.1 PURPOSE.  This Plan is a plan for employees and  consultants of the
Company and its  Affiliates and is intended to advance the best interests of the
Company,  its  Affiliates,  and its  stockholders by providing those persons who
have substantial responsibility for the management and growth of the Company and
its  Affiliates  with  additional  incentives  and an  opportunity  to obtain or
increase their proprietary interest in the Company,  thereby encouraging them to
continue in the employ of the Company or any of its Affiliates.

         1.2 EFFECTIVE DATE OF PLAN. This Plan shall be effective March 19, 1998
(the  "Effective  Date"),  if within  one year of that  date it shall  have been
approved  by at least a  majority  vote of  stockholders  voting in person or by
proxy  at a  duly  held  stockholders'  meeting,  or if  the  provisions  of the
corporate  charter,  by-laws or applicable state law prescribes a greater degree
of  stockholder  approval for this  action,  the approval by the holders of that
percentage,  at a duly held meeting of stockholders.  No Option shall be granted
pursuant to this Plan after March 19, 2008.


                                   ARTICLE II

                                   DEFINITIONS

         The words and phrases  defined in this  Article  shall have the meaning
set out in these  definitions  throughout this Plan, unless the context in which
any such word or phrase  appears  reasonably  requires a broader,  narrower,  or
different meaning.

         2.1  "AFFILIATE"  means  any  parent  corporation  and  any  subsidiary
corporation. The term "parent corporation" means any corporation (other than the
Company) in an unbroken chain of corporations ending with the Company if, at the
time of the  action or  transaction,  each of the  corporations  other  than the
Company owns stock  possessing 50% or more of the total combined voting power of
all  classes of stock in one of the other  corporations  in the chain.  The term
"subsidiary  corporation"  means any corporation  (other than the Company) in an
unbroken chain of corporations beginning with the Company if, at the time of the
action or transaction,  each of the corporations other than the last corporation
in the unbroken  chain owns stock  possessing  50% or more of the total combined
voting  power of all  classes of stock in one of the other  corporations  in the
chain.

         2.2  "BOARD OF DIRECTORS" means the board of directors of the Company.

         2.3  "CAUSE,"  when  used in  connection  with  the  termination  of an
Employee's employment or Consultant's  engagement by the Company,  means (i) any
material  failure of the Employee or  Consultant to perform his duties under any
employment or consulting agreement with the Company (other than any such failure
resulting  from the  Employee or  Consultant's  incapacity  due to  Disability),
subject to any  written  notice and  opportunity  to cure  provided  for by such
employment  or consulting  agreement,  (ii) the Employee or  Consultant's  gross
negligence or willful or  intentional  wrongdoing or misconduct  relating to his
employment or engagement by the Company, (iii) a material breach by the Employee
or  Consultant of any  proprietary  information,  inventions or  non-competition
agreement  between the Employee or Consultant  and the Company,  (iv) a material
breach by the Employee or Consultant of any insider trading,  business ethics or
similar policy of the Company,  or (iv) conviction of the Employee or Consultant
of a felony offense or a crime involving moral turpitude.


                                                         A-1

<PAGE>



         2.4      "CHANGE OF CONTROL" means:

                  (i)  the   acquisition   after  the  Effective   Date  by  any
      individual,  entity or group  (within the  meaning of Section  13(d)(3) or
      14(d)(2) of the Securities  Exchange Act of 1934, as amended) (a "Person")
      of  beneficial  ownership  of 30  percent  or more of either  (i) the then
      outstanding shares of common stock of the Company (the "Outstanding Common
      Stock") or (ii) the combined voting power of the then  outstanding  voting
      securities  of the Company  entitled to vote  generally in the election of
      directors  (the  "Outstanding  Voting  Securities"),   provided  that  for
      purposes of this  subsection  (i), the  following  acquisitions  shall not
      constitute  a Change of Control:  (A) any  acquisition  directly  from the
      Company,  (B) any  acquisition by the Company,  (C) any acquisition by any
      employee  benefit plan (or related  trust)  sponsored or maintained by the
      Company  or  any  corporation  controlled  by  the  Company,  or  (D)  any
      acquisition by any  corporation  pursuant to a transaction  which complies
      with clauses (A), (B) and (C) of subsection (iii) hereof; or

                  (ii)  individuals,  who, as of the Effective Date,  constitute
      the Board (the  "Incumbent  Board")  cease for any reason to constitute at
      least a majority of the Board,  provided  that any  individual  becoming a
      director subsequent to the Effective Date whose nomination or election, or
      nomination for election by the Company's  stockholders,  was approved by a
      vote of at least a majority of the directors then comprising the Incumbent
      Board shall be  considered as though such  individual  was a member of the
      Incumbent  Board,  but excluding,  for this purpose,  any such  individual
      whose  initial  assumption  of  office  occurs as a result of an actual or
      threatened  election  contest  with  respect to the election or removal of
      directors  or other  actual  or  threatened  solicitation  of  proxies  or
      consents by or on behalf of a Person other than the Board; or

                  (iii)   consummation   after   the   Effective   Date   of   a
      reorganization,  merger or consolidation  or sale or other  disposition of
      all or  substantially  all of the  assets  of the  Company  (a  "Corporate
      Transaction") unless, in each case, following such Corporate  Transaction,
      (A) (1) all or  substantially  all of the persons who were the  beneficial
      owners of the Outstanding Common Stock immediately prior to such Corporate
      Transaction beneficially own, directly or indirectly, more than 60 percent
      of the  then  outstanding  shares  of  common  stock  of  the  corporation
      resulting from such Corporate  Transaction,  and (2) all or  substantially
      all of the  persons  who were the  beneficial  owners  of the  Outstanding
      Voting  Securities   immediately  prior  to  such  Corporate   Transaction
      beneficially  own  directly  or  indirectly,  more than 60  percent of the
      combined voting power of the then outstanding  voting securities  entitled
      to  vote  generally  in the  election  of  directors  of  the  corporation
      resulting from such Corporate Transaction (including,  without limitation,
      a corporation  which as a result of such  transaction  owns the Company or
      all or  substantially  all of the  Company's  assets  either  directly  or
      through one or more subsidiaries) in substantially the same proportions as
      their ownership of the Outstanding Common Stock and the outstanding Voting
      Securities  immediately prior to such Corporate  Transaction,  as the case
      may be, (B) no Person  (excluding (1) any corporation  resulting from such
      Corporate  Transaction or any employee  benefit plan (or related trust) of
      the Company or such corporation  resulting from such Corporate Transaction
      and (2) any Person  approved by the Incumbent  Board)  beneficially  owns,
      directly or indirectly,  20 percent or more of the then outstanding shares
      of  common  stock  of  the  corporation   resulting  from  such  Corporate
      Transaction or the combined  voting power of the then  outstanding  voting
      securities of such  corporation  except to the extent that such  ownership
      existed prior to such Corporate Transaction and (C) at least a majority of
      the members of the board of directors of the  corporation  resulting  from
      such Corporate Transaction were members of the Incumbent Board at the time
      of the  execution  of the initial  agreement or of the action of the Board
      providing for such Corporate Transaction.

         2.5  "CODE" means the internal Revenue Code of 1986, as amended.

         2.6  "COMMITTEE"  means  the  Compensation  Committee  of the Board of
     Directors or such other committee designated by the Board of Directors. The
     Committee  shall be  comprised  solely of at least two members who are Non-
     Employee Directors and Outside Directors.

         2.7  "COMPANY"   means  Aronex   Pharmaceuticals,   Inc.,  a  Delaware
     corporation.

         2.8  "CONSULTANT"  means a person who is engaged by the  Company or any
     Affiliate to render consulting services and to whom an Option is granted.

                                                         A-2

<PAGE>



         2.9  "DISABILITY"  means a physical or mental  infirmity  which, in the
opinion of a physician selected by the Committee,  shall prevent the Employee or
Consultant  from  earning  a  reasonable  livelihood  with  the  Company  or any
Affiliate  and which can be  expected  to result in death or which has lasted or
can be expected to last for a  continuous  period of not less than 12 months and
which:  (a) was not  contracted,  suffered  or  incurred  while the  Employee or
Consultant was engaged in, or did not result from having engaged in, a felonious
criminal  enterprise;  (b)  did not  result  from  alcoholism  or  addiction  to
narcotics;  and (c) did not result from an injury incurred while a member of the
Armed Forces of the United States for which the Employee or Consultant  receives
a military pension.

         2.10  "EMPLOYEE"  means  a  person  employed  by  the  Company  or  any
Affiliate to whom an Option is granted.

         2.11 "FAIR MARKET VALUE" of the Stock as of any date means (a) the last
sale price of the Stock on that date (or, if there was no sale on such date, the
next preceding date on which there was such a sale) as reported on the principal
securities  exchange  on which the Stock is  listed;  or (b) if the Stock is not
listed on a securities  exchange,  the last sale price of the Stock on that date
(or, if there was no sale on such date,  the next  preceding date on which there
was such a sale) as reported on the Nasdaq Stock Market;  or (c) if the Stock is
not  listed on the  Nasdaq  Stock  Market,  the  average of the high and low bid
quotations  for the Stock on that date as  reported  by the  National  Quotation
Bureau Incorporated; or (d) if none of the foregoing is applicable, an amount at
the election of the Committee  equal to (x) the average  between the closing bid
and ask  prices  per share of Stock on the last  preceding  date on which  those
prices were reported or (y) an amount as determined by the Committee in its sole
discretion.

         2.12  "INCENTIVE  OPTION" means an Option granted under this Plan which
is designated as an "Incentive Option" and satisfies the requirements of Section
422 of the Code.

         2.13  "NON-EMPLOYEE  DIRECTOR" means a "non-employee  director" as that
term is defined in Rule 16b- 3 under the  Securities  Exchange  Act of 1934,  as
amended.

         2.14  "NONQUALIFIED  OPTION"  means an Option  granted  under this Plan
other than an Incentive Option.

         2.15 "OPTION" means either an Incentive Option or a Nonqualified Option
granted under this Plan to purchase shares of Stock.

         2.16 "OPTION  AGREEMENT" means the written agreement which sets out the
terms of an Option.

         2.17  "OPTIONEE"  means a person who is  granted  an Option  under this
Plan.

         2.18  "OUTSIDE  DIRECTOR"  means a member  of the  Board  of  Directors
serving on the Committee  who  satisfies  the criteria of Section  162(m) of the
Code.

         2.19 "PLAN" means the Aronex  Pharmaceuticals,  Inc.  1998 Stock Option
Plan, as set out in this document and as it may be amended from time to time.

         2.20 "STOCK" means the common stock of the Company, par value $.001 per
share,  or, in the event that the  outstanding  shares of common stock are later
changed into or exchanged  for a different  class of stock or  securities of the
Company or another corporation, that other stock or security.

         2.21 "10% STOCKHOLDER"  means an individual who, at the time the Option
is granted,  owns stock  possessing  more than 10% of the total combined  voting
power of all classes of stock of the Company or of any Affiliate.  An individual
shall be considered as owning the stock owned, directly or indirectly, by or for
his  brothers  and  sisters  (whether  by the  whole  or  half  blood),  spouse,
ancestors, and lineal descendants;  and stock owned, directly or indirectly,  by
or for a  corporation,  partnership,  estate,  or trust,  shall be considered as
being  owned   proportionately   by  or  for  its   stockholders,   partners  or
beneficiaries.



                                                         A-3

<PAGE>



                                   ARTICLE III

                                   ELIGIBILITY

         The  individuals  who shall be  eligible to receive  Incentive  Options
shall be those key  employees  of the  Company or any of its  Affiliates  as the
Committee  shall  determine  from  time to time.  The  individuals  who shall be
eligible  to  receive  Nonqualified  Options  shall be those key  employees  and
consultants  of the  Company or any of its  Affiliates  as the  Committee  shall
determine  from time to time.  No member of the  Committee  shall be eligible to
receive any Option or to receive  stock,  stock options,  or stock  appreciation
rights under any other plan of the Company or any of its Affiliates, if to do so
would  cause the  individual  not to be a  Non-Employee  Director  or an Outside
Director. The Board of Directors may designate one or more individuals who shall
not be  eligible to receive  any Option  under this Plan or under other  similar
plans of the Company.


                                   ARTICLE IV

                     GENERAL PROVISIONS RELATING TO OPTIONS

         4.1  AUTHORITY  TO GRANT  OPTIONS.  The  Committee  may  grant to those
individuals,  as it shall from time to time  determine,  Options under the terms
and conditions of this Plan. Subject only to any applicable  limitations set out
in this  Plan,  the  number of shares of Stock to be covered by any Option to be
granted to an Employee  or  Consultant  of the Company or any of its  Affiliates
shall be as determined by the Committee.

         4.2 DEDICATED SHARES.  The total number of shares of Stock with respect
to which Options may be granted under the Plan shall be 750,000 shares of Stock.
The shares may be treasury shares or authorized but unissued  shares.  The total
number of shares of Stock with respect to which Incentive Options may be granted
under the Plan shall be 750,000 shares.  The maximum number of shares subject to
Options which may be issued to any Optionee  under the Plan during any period of
three consecutive  years is 250,000 shares.  The number of shares stated in this
Section 4.2 shall be subject to adjustment in accordance  with the provisions of
Section 4.5.

         In the event that any outstanding  Option shall expire or terminate for
any reason or any Option is  surrendered,  the shares of Stock  allocable to the
unexercised  portion of that Option may again be subject to an Option  under the
Plan.

         4.3  NON-TRANSFERABILITY.  Options  shall  not be  transferable  by the
Optionee  otherwise  than  (i)  by  will  or  under  the  laws  of  descent  and
distribution or (ii) pursuant to a qualified domestic relations order as defined
in the Code, in Title I of the Employee  Retirement  Income  Security Act, or in
the rules and regulations as may be in effect from time to time thereunder,  and
shall be exercisable, during the Optionee's lifetime, only by him.

         4.4  REQUIREMENTS  OF LAW. The Company shall not be required to sell or
issue any Stock  under any Option if  issuing  that Stock  would  constitute  or
result in a violation  by the  Optionee or the Company of any  provision  of any
law,  statute,  or regulation of any governmental  authority.  Specifically,  in
connection   with  any  applicable   statute  or  regulation   relating  to  the
registration of securities,  upon exercise of any Option,  the Company shall not
be  required  to issue any Stock  unless the  Committee  has  received  evidence
satisfactory  to it to the  effect  that  the  holder  of that  Option  will not
transfer the Stock except in accordance with applicable law,  including  receipt
of an opinion  of counsel  satisfactory  to the  Company to the effect  that any
proposed  transfer  complies  with  applicable  law.  The  determination  by the
Committee on this matter  shall be final,  binding and  conclusive.  The Company
may, but shall in no event be obligated  to,  register any Stock covered by this
Plan  pursuant to  applicable  securities  laws of any country or any  political
subdivision.  In the event the Stock  issuable  on  exercise of an Option is not
registered,  the Company may imprint on the certificate evidencing the Stock any
legend that counsel for the Company  considers  necessary or advisable to comply
with  applicable  law.  The  Company  shall not be  obligated  to take any other
affirmative  action in order to cause the exercise of an Option and the issuance
of shares  thereunder,  to comply with any law or regulation of any governmental
authority.

         4.5  CHANGES IN  THE COMPANY'S CAPITAL  STRUCTURE.   The  existence  of
outstanding  Options  shall  not  affect  in any way the  right  or power of the
Company or its stockholders to make or authorize any adjustments,

                                                         A-4

<PAGE>



recapitalizations,  reorganizations  or other changes in the  Company's  capital
structure or its business, or any merger or consolidation of the Company, or any
issue of bonds,  debentures,  preferred  or prior  preference  stock ahead of or
affecting the Stock or its rights,  or the  dissolution  or  liquidation  of the
Company,  or any sale or transfer of all or any part of its assets or  business,
or any other  corporate  act or  proceeding,  whether of a similar  character or
otherwise.

         If the Company shall effect a subdivision or consolidation of shares or
other capital  readjustment,  the payment of a stock dividend, or other increase
or reduction of the number of shares of the Stock outstanding, without receiving
compensation for it in money,  services or property then (a) the number,  class,
and per share price of shares of Stock subject to outstanding Options under this
Plan shall be appropriately  adjusted in such a manner as to entitle an Optionee
to  receive  upon  exercise  of  an  Option,   for  the  same   aggregate   cash
consideration,  the  equivalent  total  number and class of shares he would have
received  had he  exercised  his Option in full  immediately  prior to the event
requiring the  adjustment;  and (b) the number and class of shares of Stock then
reserved to be issued under the Plan shall be adjusted by  substituting  for the
total number and class of shares of Stock then  reserved,  that number and class
of shares of Stock that would have been received by the owner of an equal number
of  outstanding  shares  of such  class  of  Stock as the  result  of the  event
requiring the adjustment.

         If the Company is merged or consolidated  with another  corporation and
the Company is not the surviving corporation, or if the Company is liquidated or
sells or otherwise  disposes of substantially  all its assets while  unexercised
Options  remain  outstanding  under this Plan,  (a) subject to the provisions of
clause  (c)  below,  after  the  effective  date of the  merger,  consolidation,
liquidation,  sale or other  disposition,  as the case may be, each holder of an
outstanding  Option shall be entitled,  upon exercise of the Option, to receive,
in lieu of shares of Stock,  the  number and class or classes of shares of stock
or other securities or property to which the holder would have been entitled if,
immediately  prior  to the  merger,  consolidation,  liquidation,  sale or other
disposition,  the  holder had been the holder of record of a number of shares of
Stock  equal  to the  number  of  shares  as to  which  the  Option  shall be so
exercised;  (b) the Committee  shall waive any limitations set out in or imposed
under  this  Plan so that  all  Options,  from  and  after a date  prior  to the
effective  date  of  the  merger,  consolidation,  liquidation,  sale  or  other
disposition,  as  the  case  may  be,  specified  by  the  Committee,  shall  be
exercisable  in full;  and (c) all  outstanding  Options  may be canceled by the
Committee as of the effective  date of any merger,  consolidation,  liquidation,
sale or other disposition,  if (i) notice of cancellation shall be given to each
holder of an Option  and (ii) each  holder of an Option  shall have the right to
exercise that Option in full (without  regard to any  limitations  set out in or
imposed under this Plan or the Option  Agreement  granting that Option) during a
period  set by  the  Committee  preceding  the  effective  date  of the  merger,
consolidation,  liquidation,  sale or other disposition and, if in the event all
outstanding  Options may not be  exercised in full under  applicable  securities
laws  without  registration  of the shares of Stock  issuable on exercise of the
Options,  the  Committee  may limit the exercise of the Options to the number of
shares of Stock,  if any, as may be issued without  registration.  The method of
choosing  which Options may be exercised,  and the number of shares of Stock for
which  Options may be exercised,  shall be solely  within the  discretion of the
Committee.

         The issue by the Company of shares of stock of any class, or securities
convertible  into  shares of stock of any class,  for cash or  property,  or for
labor or services  either  upon  direct  sale or upon the  exercise of rights or
warrants to subscribe for them, or upon  conversion of shares or  obligations of
the Company  convertible into shares or other securities,  shall not affect, and
no  adjustment  by reason of such  issuance  shall be made with  respect to, the
number, class, or price of shares of Stock then subject to outstanding Options.

         4.6  CHANGES  OF  CONTROL.  In the  event of a Change of  Control,  the
Committee may, in its  discretion,  at the time an Option is granted or any time
thereafter:  (i) provide for the acceleration of any time period relating to the
exercise of the  Option,  (ii)  provide for the  purchase of the Option upon the
Optionee's  request for an amount of cash or other property that could have been
received  upon the  exercise  of the Option had the Option  been then  currently
exercisable,  (iii) adjust the terms of the Option in a manner determined by the
Committee to reflect the Change of Control, (iv) cause the Option to be assumed,
or new rights substituted  therefore,  by another entity, or (v) make such other
provisions as the  Committee may consider  equitable and in the best interest of
the Company.



                                                         A-5

<PAGE>



                                    ARTICLE V

                                     OPTIONS

         5.1 TYPE OF OPTION.  The Committee shall specify whether a given Option
shall constitute an Incentive Option or a Nonqualified Option.

         5.2 OPTION  PRICE.  The price at which Stock may be purchased  under an
Option  shall not be less than the greater of: (a) 100% of the Fair Market Value
of the shares of Stock on the date the  Option is  granted or (b) the  aggregate
par value of the shares of Stock on the date the Option is granted.  In the case
of any 10%  Stockholder,  the price at which  shares  of Stock may be  purchased
under an  Incentive  Option shall not be less than 110% of the Fair Market Value
of the Stock on the date the Incentive Option is granted.

         5.3 DURATION OF OPTIONS;  TERMINATION.  No Option shall be  exercisable
after the  expiration  of 10 years from the date the Option is  granted.  In the
case of a 10% Stockholder,  no Incentive  Option shall be exercisable  after the
expiration of five years from the date the Incentive  Option is granted.  Unless
otherwise provided in the Option Agreement or by the Committee:

                  (a) If the  employment  or  engagement  of an  Optionee by the
      Company shall terminate for any reason other than Cause,  Disability,  the
      voluntary  retirement  of the Optionee in  accordance  with the  Company's
      retirement  policy as then in effect  or the  death of the  Optionee:  (i)
      Options granted to such Optionee, to the extent that they were exercisable
      at the  time of such  termination,  shall  remain  exercisable  until  the
      expiration  of 90 days  after such  termination,  on which date they shall
      expire, and (ii) Options granted to such Optionee, to the extent that they
      were not exercisable at the time of such termination,  shall expire at the
      close of business on the date of such termination; provided, however, that
      no Option shall be exercisable after the expiration of its term.

                  (b) If the  employment  or  engagement  of an  Optionee by the
      Company  shall  terminate  on account  of the  Disability,  the  voluntary
      retirement  of the Optionee in accordance  with the  Company's  retirement
      policy as then in effect or the death of the Optionee: (i) Options granted
      to such Optionee,  to the extent that they were exercisable at the time of
      such  termination,  shall remain  exercisable  until the expiration of one
      year after such  termination,  on which date they shall  expire,  and (ii)
      Options  granted  to such  Optionee,  to the  extent  that  they  were not
      exercisable at the time of such termination,  shall expire at the close of
      business  on the  date of such  termination;  provided,  however,  that no
      Option shall be exercisable after the expiration of its term.

                  (c)  In  the  event  of  the   termination  of  an  Optionee's
      employment or engagement for Cause,  all  outstanding  Options  granted to
      such Optionee shall expire at the  commencement of business on the date of
      such termination.

         5.4 AMOUNT EXERCISABLE. Each Option may be exercised from time to time,
in whole or in part, in the manner and subject to the  conditions the Committee,
in its sole  discretion,  may  provide in the Option  Agreement,  as long as the
Option is valid and  outstanding.  To the extent that the aggregate  Fair Market
Value  (determined  as of the time an Incentive  Option is granted) of the Stock
with respect to which Incentive Options first become exercisable by the Optionee
during any calendar year (under this Plan and any other  incentive  stock option
plan(s) of the Company or any Affiliate) exceeds $100,000, the Incentive Options
shall  be  treated  as  Nonqualified  Options.  In  making  this  determination,
Incentive  Options  shall be taken into  account in the order in which they were
granted.

         5.5 EXERCISE OF OPTIONS. Each Option shall be exercised by the delivery
of written  notice to the Company,  to the attention of its  Secretary,  setting
forth the  number of shares of Stock  with  respect to which the Option is to be
exercised,  together with: (a) cash, wire transfer, certified check, bank draft,
or postal or express  money  order  payable to the order of the  Company  for an
amount  equal to the  option  price of the  shares,  or (b) if  approved  by the
Committee,  Stock at its Fair Market Value on the date of  exercise,  and/or any
other form of payment which is acceptable to the  Committee,  and specifying the
address to which the  certificates  for the shares are to be mailed.  Subject to
Sections  4.4 and 8.3,  as  promptly  as  practicable  after  receipt of written
notification and payment, the Company shall deliver to the Optionee certificates
for the number of shares  with  respect to which the Option has been  exercised,
issued in the

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Optionee's  name. If shares of Stock are used in payment of the exercise  price,
the aggregate Fair Market Value of the shares of Stock tendered must be equal to
or less than the aggregate  exercise  price of the shares being  purchased  upon
exercise  of the  Option,  and any  difference  must be paid by cash,  certified
check,  bank draft,  or postal or express  money order  payable to the  Company.
Delivery of the shares shall be deemed  effected  for all purposes  when a stock
transfer  agent of the Company  shall have  deposited  the  certificates  in the
United States mail,  addressed to the Optionee,  at the address specified by the
Optionee.

         Whenever an Option is exercised by exchanging  shares of Stock owned by
the Optionee, the Optionee shall deliver to the Company certificates  registered
in the name of the Optionee representing a number of shares of Stock legally and
beneficially owned by the Optionee,  free of all liens, claims, and encumbrances
of every kind,  accompanied by stock powers duly endorsed in blank by the record
holder of the shares represented by the certificates (with signature  guaranteed
by a commercial bank or trust company or by a brokerage firm having a membership
on a registered national stock exchange).  The delivery of certificates upon the
exercise of Options is subject to the condition  that the person  exercising the
Option  provide the Company with the  information  the Company might  reasonably
request pertaining to exercise, sale or other disposition of an Option.

         5.6 SUBSTITUTION  OPTIONS.  Options may be granted under this Plan from
time to time in  substitution  for  stock  options  held by  employees  of other
corporations who are about to become employees of or affiliated with the Company
or any  Affiliate as the result of a merger or  consolidation  of the  employing
corporation with the Company or any Affiliate, or the acquisition by the Company
or any Affiliate of the assets of the employing corporation,  or the acquisition
by the Company or any  Affiliate of stock of the  employing  corporation  as the
result of which it becomes an Affiliate of the Company. The terms and conditions
of the substitute Options granted may vary from the terms and conditions set out
in this Plan  (including,  without  limitation,  the terms and  conditions  with
respect  to the price at which  Stock may be  purchased  under an Option) to the
extent the Committee,  at the time of grant, may deem appropriate to conform, in
whole or in part, to the  provisions of the stock  options in  substitution  for
which they are granted.

         5.7 NO RIGHTS AS  STOCKHOLDER.  No Optionee  shall have any rights as a
stockholder  with respect to Stock  covered by his Option until the date a stock
certificate is issued for the Stock.


                                   ARTICLE VI

                                 ADMINISTRATION

         This Plan shall be  administered  by the  Committee.  All  questions of
interpretation  and application of this Plan and Options shall be subject to the
determination of the Committee. A majority of the members of the Committee shall
constitute a quorum.  All  determinations  of the  Committee  shall be made by a
majority of its members.  Any decision or  determination  reduced to writing and
signed by a majority of the members shall be as effective as if it had been made
by a majority  vote at a meeting  properly  called and held.  This Plan shall be
administered  in such a manner as to permit the Options  granted  under it which
are  designated  to be  Incentive  Options to qualify as Incentive  Options.  In
carrying out its authority  under this Plan,  the Committee  shall have full and
final  authority  and  discretion,  including  but not limited to the  following
rights, powers and authorities, to:

     (a)  determine  the persons to whom and the time or times at which  Options
will be made,

     (b) determine the number of shares and the purchase  price of Stock covered
in each Option, subject to the terms of the Plan,

     (c) determine the terms,  provisions and  conditions of each Option,  which
need not be identical,

     (d) accelerate the time at which any outstanding Option may be exercised,

     (e)  define the  effect,  if any,  on an Option of the  death,  disability,
retirement, or termination of employment of the Optionee,

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     (f)  prescribe,  amend  and  rescind  rules  and  regulations  relating  to
administration of this Plan, and

     (g) make  all  other  determinations  and take  all  other  actions  deemed
necessary, appropriate, or advisable for the proper administration of this Plan.

The  actions of the  Committee  in  exercising  all of the rights,  powers,  and
authorities  set out in this Article and all other  Articles of this Plan,  when
performed in good faith and in its sole judgment, shall be final, conclusive and
binding on all parties.


                                   ARTICLE VII

                        AMENDMENT OR TERMINATION OF PLAN

         The Board of Directors  of the Company may amend,  terminate or suspend
this Plan at any time, in its sole and absolute discretion;  provided,  however,
that to the extent required to maintain the status of any Incentive Option under
the Code, no amendment  that would (a) change the aggregate  number of shares of
Stock  which may be issued  under  Incentive  Options,  (b)  change the class of
employees  eligible to receive Incentive  Options,  or (c) decrease the exercise
price for Incentive Options below the Fair Market Value of the Stock at the time
it is granted, shall be made without the approval of the Company's stockholders.
Subject to the  preceding  sentence,  the Board shall have the power to make any
changes in this Plan and in the regulations and administrative  provisions under
it or in any outstanding  Incentive  Option as in the opinion of counsel for the
Company  may be  necessary  or  appropriate  from  time to time  to  enable  any
Incentive  Option granted under this Plan to continue to qualify as an incentive
stock option or such other stock  option as may be defined  under the Code so as
to receive preferential Federal income tax treatment.


                                                    ARTICLE VIII

                                                    MISCELLANEOUS

         8.1 NO  ESTABLISHMENT  OF A TRUST FUND. No property  shall be set aside
nor shall a trust  fund of any kind be  established  to secure the rights of any
Optionee under this Plan. All Optionees  shall at all times rely solely upon the
general  credit of the  Company for the  payment of any  benefit  which  becomes
payable under this Plan.

         8.2 NO  EMPLOYMENT  OBLIGATION.  The  granting of any Option  shall not
constitute  an  employment  contract,  express or  implied,  nor impose upon the
Company or any  Affiliate  any  obligation  to employ or  continue to employ any
Optionee.  The right of the Company or any Affiliate to terminate the employment
of any person shall not be  diminished or affected by reason of the fact that an
Option has been granted to him.

         8.3 TAX WITHHOLDING.  The Company or any Affiliate shall be entitled to
deduct from other  compensation  payable to each  Optionee any sums  required by
federal,  state,  or local tax law to be withheld  with  respect to the grant or
exercise of an Option. In the alternative,  the Company may require the Optionee
(or other person  exercising the Option) to pay the sum directly to the employer
corporation. If the Optionee (or other person exercising the Option) is required
to pay the sum  directly,  payment  in cash or by check of such  sums for  taxes
shall be  delivered  within  ten days  after  the date of  exercise  or lapse of
restrictions.  The Company shall have no obligation  upon exercise of any Option
until payment has been received,  unless  withholding  (or offset against a cash
payment) as of or prior to the date of exercise is  sufficient to cover all sums
due with respect to that exercise.  The Company and its Affiliates  shall not be
obligated to advise an Optionee of the  existence of the tax or the amount which
the employer corporation will be required to withhold.

         8.4  WRITTEN  AGREEMENT.  Each  Option  shall be  embodied in a written
Option Agreement which shall be subject to the terms and conditions of this Plan
and shall be  signed by the  Optionee  and by a member of the  Committee  and an
officer of the Company on behalf of the  Committee  and the Company.  The Option
Agreement may contain any other  provisions that the Committee in its discretion
shall deem advisable which are not inconsistent with the terms of this Plan.

                                                         A-8

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     8.5  INDEMNIFICATION  OF THE  COMMITTEE  AND THE BOARD OF  DIRECTORS.  With
respect to administration of this Plan, the Company shall indemnify each present
and future member of the Committee and the Board of Directors against,  and each
member of the  Committee  and the Board of Directors  shall be entitled  without
further  action  his  part to  indemnity  from the  Company  for,  all  expenses
(including  attorneys'  fees, the amount of judgments and the amount of approved
settlements  made with a view to the  curtailment of costs of litigation,  other
than  amounts  paid  to  the  Company  itself)  reasonably  incurred  by  him in
connection  with or arising out of any action,  suit,  or proceeding in which he
may be involved by reason of his being or having been a member of the  Committee
and/or the Board of Directors, whether or not he continues to be a member of the
Committee   and/or  the  Board  of  Directors  at  the  time  of  incurring  the
expenses--including, without limitation, matters as to which he shall be finally
adjudged  in any  action,  suit or  proceeding  to have been  found to have been
negligent in the  performance of his duty as a member of the Committee or of the
Board of  Directors.  However,  this  indemnity  shall not include any  expenses
incurred by any member of the Committee and/or the Board of Directors in respect
of matters  as to which he shall be  finally  adjudged  in any  action,  suit or
proceeding to have been guilty of gross negligence or willful  misconduct in the
performance  of his duty as a member of the Committee or the Board of Directors.
In addition,  no right of indemnification  under this Plan shall be available to
or enforceable by any member of the Committee or the Board of Directors  unless,
within 60 days after  institution of any action,  suit or  proceeding,  he shall
have offered the Company, in writing,  the opportunity to handle and defend same
at its own expense.  This right of indemnification shall inure to the benefit of
the heirs,  executors or  administrators of each member of the Committee and the
Board of  Directors  and shall be in  addition  to all  other  rights to which a
member of the  Committee  and the Board of Directors may be entitled as a matter
of law, contract, or otherwise.

         8.6 GENDER. If the context  requires,  words of one gender when used in
this Plan shall  include  the others  and words used in the  singular  or plural
shall include the other.

         8.7  HEADINGS.  Headings of Articles  and  Sections  are  included  for
convenience of reference only and do not constitute  part of this Plan and shall
not be used in construing the terms of this Plan.

         8.8 OTHER  COMPENSATION  PLANS.  The  adoption  of this Plan  shall not
affect any other stock option,  incentive or other compensation or benefit plans
in effect for the Company or any  Affiliate,  nor shall this Plan  preclude  the
Company from establishing any other forms of incentive or other compensation for
employees of the Company or any Affiliate.

         8.9 OTHER  OPTIONS.  The grant of an Option  shall not  confer  upon an
Optionee  the right to  receive  any  future or other  Options  under this Plan,
whether or not Options may be granted to similarly  situated  Optionees,  or the
right to receive  future Options upon the same terms or conditions as previously
granted.

         8.10  ARBITRATION  OF  DISPUTES.  Any  controversy  arising  out  of or
relating to the Plan or an Option  Agreement  shall be  resolved by  arbitration
conducted  pursuant  to  the  arbitration  rules  of  the  American  Arbitration
Association. The arbitration shall be final and binding on the parties.

     8.11  GOVERNING  LAW.  The  provisions  of this  Plan  shall be  construed,
administered, and governed under the laws of the State of Delaware.



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