ARONEX PHARMACEUTICALS INC
SC 13D, 1999-03-05
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934




                          Aronex Pharmaceuticals, Inc.
- - - - - - - - - - - - - --------------------------------------------------------------------------------
                                (Name of Issuer)

                     Common Stock, Par Value $.001 Per Share
- - - - - - - - - - - - - --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   042666 20 6
                    ----------------------------------------
                                 (CUSIP Number)

                                Martin P. Sutter
                   Essex Woodlands Health Ventures IV, L.L.C.
                        2170 Buckthorne Place, Suite 170
                           The Woodlands, Texas 77380
                                 (281) 367-9999
- - - - - - - - - - - - - --------------------------------------------------------------------------------
   (Name, Address and Telephone Number of Person Authorized to Receive Notices
                               and Communications)

                                February 23, 1999
             -----------------------------------------------------
                  (Date of Event which Requires Filing of this
                                   Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following box
/_/.

NOTE:  Schedules  filed in paper format shall include a signed original and five
copies of the  schedule,  including  all  exhibits.  See Rule 13d-7(b) for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



<PAGE>





                                  SCHEDULE 13D

- - - - - - - - - - - - - --------------------------------                   -----------------------------
CUSIP No.          042666 20 6                           Page 2 of 8 Pages
- - - - - - - - - - - - - --------------------------------                   -----------------------------

- - - - - - - - - - - - - --------------------------------------------------------------------------------
1      NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
          Essex Woodlands Health Ventures IV, LLC 
          Federal ID number:  76-0573196
- - - - - - - - - - - - - --------------------------------------------------------------------------------
2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)    /_/
                                                                               
                                                                    (b)    /x/ 
- - - - - - - - - - - - - --------------------------------------------------------------------------------
3      SEC USE ONLY
- - - - - - - - - - - - - --------------------------------------------------------------------------------
4      SOURCE OF FUNDS*
                WC
- - - - - - - - - - - - - --------------------------------------------------------------------------------
5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
       ITEMS 2(d) OR  2(e)                                                 /_/
- - - - - - - - - - - - - --------------------------------------------------------------------------------
6      CITIZENSHIP OR PLACE OF ORGANIZATION
                   U.S.A.
- - - - - - - - - - - - - --------------------------------------------------------------------------------
           NUMBER OF            7        SOLE VOTING POWER
            SHARES                             -0-
         BENEFICIALLY           ------------------------------------------------
           OWNED BY             8        SHARED VOTING POWER
             EACH                  2,285,715 shares of Common Stock (1)
           REPORTING            ------------------------------------------------
            PERSON              9        SOLE DISPOSITIVE POWER
             WITH                                -0-
                                ------------------------------------------------
                                10       SHARED DISPOSITIVE POWER
                                         2,285,715 shares of Common Stock (1)
- - - - - - - - - - - - - --------------------------------------------------------------------------------
11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  2,285,715 shares of Common Stock (1)
- - - - - - - - - - - - - --------------------------------------------------------------------------------
12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES* 
                                                                         /_/
- - - - - - - - - - - - - --------------------------------------------------------------------------------
13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                   10.2%
- - - - - - - - - - - - - --------------------------------------------------------------------------------
14      TYPE OF REPORTING PERSON
                   OO; Limited Liability Company
- - - - - - - - - - - - - --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

(1)  Includes  2,285,715  shares of Common Stock owned by Essex Woodlands Health
     Ventures Fund IV, L.P., of which Essex Woodlands Health Ventures IV, LLC is
     the general partner.



<PAGE>





SCHEDULE 13D

- - - - - - - - - - - - - --------------------------------                       -------------------------
CUSIP No.          042666 20 6                             Page 3 of 8 Pages
- - - - - - - - - - - - - --------------------------------                       -------------------------

- - - - - - - - - - - - - --------------------------------------------------------------------------------
1         NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                   Essex Woodlands Health Ventures Fund IV, L.P.   
                   Federal ID number:    76-0573196
- - - - - - - - - - - - - --------------------------------------------------------------------------------
2         CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*       (a)     /_/

                                                                  (b)     /x/
- - - - - - - - - - - - - --------------------------------------------------------------------------------
3         SEC USE ONLY
- - - - - - - - - - - - - --------------------------------------------------------------------------------
4         SOURCE OF FUNDS*
                   WC
- - - - - - - - - - - - - --------------------------------------------------------------------------------
5         CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT 
          TO ITEMS 2(d) OR  2(e)                                          /_/
- - - - - - - - - - - - - --------------------------------------------------------------------------------
6         CITIZENSHIP OR PLACE OF ORGANIZATION
                   U.S.A.
- - - - - - - - - - - - - --------------------------------------------------------------------------------
           NUMBER OF            7        SOLE VOTING POWER
            SHARES                                -0-
         BENEFICIALLY           ------------------------------------------------
           OWNED BY             8        SHARED VOTING POWER
             EACH                         2,285,715 shares of Common Stock
           REPORTING            ------------------------------------------------
            PERSON              9        SOLE DISPOSITIVE POWER
             WITH                                  -0-
                                ------------------------------------------------
                                10       SHARED DISPOSITIVE POWER
                                         2,285,715 shares of Common Stock     
- - - - - - - - - - - - - --------------------------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                  2,285,715 shares of Common Stock
- - - - - - - - - - - - - --------------------------------------------------------------------------------
12       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES* 
                                                                             /_/
- - - - - - - - - - - - - --------------------------------------------------------------------------------
13        PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
                   10.2%
- - - - - - - - - - - - - --------------------------------------------------------------------------------
14        TYPE OF REPORTING PERSON
                   PN
- - - - - - - - - - - - - --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!




<PAGE>
                                                              Page4 of 8 Pages


                         ORIGINAL REPORT ON SCHEDULE 13D


Item 1.      Security and Issuer

       This  statement  relates to the shares of common  stock,  par value $.001
("Common Stock"), of Aronex  Pharmaceuticals,  Inc., a Delaware corporation (the
"Corporation"),  which has its principal  executive  offices at 8707  Technology
Forest Place, The Woodlands, Texas 77381-1191.

Item 2.      Identity and Background

       (a) This  statement  is being  filed  jointly by Essex  Woodlands  Health
Ventures  IV, LLC, a Delaware  limited  liability  company  and Essex  Woodlands
Health  Ventures  Fund IV, L.P.,  a Delaware  limited  partnership  ("Fund IV").
Information  provided in this  Schedule  13D is as of the date of filing  unless
otherwise specified below.

       (b) Essex  Woodlands  Health  Ventures IV, LLC.  The business  address of
Essex Woodlands Health Ventures IV, LLC is 2170 Buckthorne Place, Suite 170, The
Woodlands,  Texas 77380.  Essex Woodlands  Health Ventures IV, LLC is engaged in
the business of managing an investment portfolio.

       Information concerning each controlling persons of Essex Woodlands Health
Ventures  IV,  LLC,  which  information  is  disclosed  in response to Item 2 of
General Instruction C to Schedule 13D, is attached hereto as Appendix A.

       (c) Essex Woodlands Health Ventures Fund IV, L.P. The business address of
Fund IV is 2170 Buckthorne Place, Suite 170, The Woodlands, Texas 77380. Fund IV
is  engaged  in the  business  of  investing  in  healthcare  and  biotechnology
companies.  Essex  Woodlands  Health  Ventures IV, LLC is the general partner of
Fund IV.

       (d) During the last five years,  neither Essex Woodlands  Health Ventures
IV, LLC or Fund IV, nor any of the  individuals  listed on Appendix A, have been
convicted in any criminal  proceeding  (excluding traffic violations and similar
misdemeanors).

       (e) During the last five years,  neither Essex Woodlands  Health Ventures
IV, LLC or Fund IV, nor any of the individuals listed on Appendix A, have been a
party to a civil  proceeding of a judicial or  administrative  body of competent
jurisdiction and as a result of such proceeding was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, federal or state securities laws or finding any
violation with respect to such laws.


Item 3.      Source and Amount of Funds or Other Consideration

       Essex Woodlands  Health Ventures IV, LLC and Fund IV acquired  beneficial
ownership of 2,285,715  shares of Common Stock on Februrary 23, 1999 for $2.1875
per share in connection with the Corporation's  registered public offering of an
aggregate of 6,000,000 shares of Common Stock.





<PAGE>


                                                            Page 5 of 8 Pages

Item 4.      Purpose of Transaction

       Essex  Woodlands  Health Ventures IV, LLC and Fund IV acquired the shares
of Common Stock reported herein solely for the purpose of investment by Fund IV.
Essex  Woodlands  Health  Ventures  IV,  LLC  and  Fund IV may  make  additional
purchases  of shares of Common  Stock  either in the open  market or in  private
transactions  depending on the Corporation's  business,  prospects and financial
condition,  the market for the Common Stock, general economic conditions,  money
and stock market conditions and other future developments.

Item 5.      Interest in Securities of the Company

       There were 22,415,664  shares of Common Stock  outstanding as of February
23, 1999,  the closing date of the  Corporation's  public  offering of 6,000,000
shares of Common Stock.

       Essex Woodlands  Health Ventures IV, LLC and Fund IV are deemed to be the
beneficial owners of the 2,285,715 shares of Common Stock owned directly by Fund
IV,  which  shares  constitute  approximately  10.2%  of the  total  issued  and
outstanding Common Stock as of February 23, 1999.

       (a) The number of shares of Common  Stock as to which there is sole power
to  vote or to  direct  the  vote,  sole  power  to  dispose  or to  direct  the
disposition,  or shared  power to dispose or direct  the  disposition  for Essex
Woodlands Health Ventures IV, LLC and Fund IV is set forth on the cover pages of
this Statement on Schedule 13D, and such  information is incorporated  herein by
reference.

       (b) There have been no reportable transactions with respect to the Common
Stock  within the last 60 days by Essex  Woodlands  Health  Ventures IV, LLC and
Fund IV except for the acquisition of beneficial ownership of Common Stock being
reported on this Schedule 13D.

       (c) Essex Woodlands Health Ventures IV, LLC and Fund IV have the right to
receive  distributions  from,  and the proceeds from the sale of, the respective
shares of Common Stock  reported as owned  directly by such persons on the cover
pages of this Statement on Schedule 13D.

       (d) Not applicable.

Item 6.      Contracts, Arrangements, Understandings or Relationships with 
             respect to Securities of the Company

       There are no contracts,  arrangements,  understandings  or  relationships
among Essex  Woodlands  Health  Ventures  IV, LLC and Fund IV and between  Essex
Woodlands Health Ventures IV, LLC and Fund IV and any person with respect to any
securities of Aronex Pharmaceuticals, Inc.

Item 7.      Material to be filed as Exhibits

       There are no written agreements, contracts, arrangements, understandings,
plans or  proposals  relating  to (i) the  borrowing  of funds  to  finance  the
purchase of shares of Common  Stock,  (ii) the  acquisition  of issuer  control,
liquidation,  sale of  assets,  merger,  or  change  in  business  or  corporate
structure  and (iii) the  transfer  or  voting  of the  shares of Common  Stock,
finder's  fees,  joint  ventures,  options,  puts,  calls,  guarantees of loans,
guarantees against loss or of profit, or the giving or withholding of an proxy.

       Exhibit 99.1 -- Agreement pursuant to Rule 13d-1(k)(1)(iii)




<PAGE>


                                                           Page 6 of 8 Pages

                                    SIGNATURE

       After reasonable inquiry and to the best of my knowledge and belief, each
of the  undersigned  certify that the information set forth in this statement is
true, complete and correct.

Date: March 5, 1999



                            ESSEX WOODLANDS HEALTH VENTURES IV, LLC



                            By:    /s/ Martin P. Sutter
                                   -------------------------------------------
                                     Name:  Martin P. Sutter
                                     Title:  Managing Director


                            ESSEX WOODLANDS HEALTH VENTURES FUND IV, L.P.

                            By:    Essex Woodlands Health Ventures IV, LLC,
                                   its General Partner


                                       By:  /s/ Martin P. Sutter
                                           ----------------------------------
                                            Name:  Martin P. Sutter
                                            Title:  Managing Director







<PAGE>


                                                             Page 7 of 8 Pages


                                   APPENDIX A

Essex Woodlands Health Ventures IV, L.L.C.

Executive Officers
- - - - - - - - - - - - - ------------------

James L. Currie                     Managing Director
Marc S. Sandroff                    Managing Director
Martin P. Sutter                    Managing Director


The address of James L. Currie is 190 South LaSalle Street, Suite 2800, Chicago,
IL 60603.

The address of Marc S. Sandroff is 20 East Cedar, Atp. #14C, Chicago, IL 60611.

The  address of Martin P.  Sutter is c/o Essex  Woodlands  Health  Ventures  IV,
L.L.C., 2170 Buckthorne Place, Suite 170, The Woodlands, Texas 77380.

Each of the executive offices above are citizens of the United States.

Although each of the Managing Directors above owns a one-third interest in Essex
Woodlands Health Ventures IV, L.L.C., none of such persons  individually control
Essex Woodlands Health Ventures IV, L.L.C.





<PAGE>


                                                          Page 8 of 8 Pages

EXHIBIT 99.1


         Pursuant to Rule 13d-1(k)(1)(iii) under Regulation 13D-G of the General
Rules and  Regulations  of the  Securities  and  Exchange  Commission  under the
Securities  Exchange Act of 1934,  as amended,  each of the  undersigned  hereby
agrees  that the  Schedule  13D to which this  Agreement  is  attached,  and any
amendments thereto, may be filed on behalf of such person.

         This Agreement may be executed in any number of  counterparts,  each of
which shall be deemed an original,  but all of which together  shall  constitute
one and the same instrument.

Dated:   March 5, 1999


                                ESSEX WOODLANDS HEALTH VENTURES IV, LLC



                                 By:    /s/ Martin P. Sutter
                                        ------------------------------------
                                        Name:  Martin P. Sutter
                                        Title:  Managing Director


                                ESSEX WOODLANDS HEALTH VENTURES FUND IV, L.P.

                                 By:    Essex Woodlands Health Ventures IV, LLC,
                                        its General Partner



                                 By:    /s/ Martin P. Sutter
                                        -------------------------------------
                                        Name:  Martin P. Sutter
                                        Title:  Managing Director







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