NORTH AMERICAN VACCINE INC
POS AM, 1998-06-24
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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As filed with the Securities and Exchange Commission on June 24, 1998
                                                     Registration No. 333-8851

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                         _______________________________

                         POST-EFFECTIVE AMENDMENT NO. 2
                                       TO
                                    FORM S-3
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                        _______________________________

                          NORTH AMERICAN VACCINE, INC.
             (Exact name of registrant as specified in its charter)

       Canada                                98-0121241
(State or other jurisdiction of              (I.R.S. Employer
incorporation or organization)               Identification No.)

                            12103 Indian Creek Court
                           Beltsville, Maryland 20705
                                 (301) 419-8400
          (Address, including zip code, and telephone number, including
            area code, of registrant's principal executive offices)


                           Daniel J. Abdun-Nabi, Esq.
                      Senior Vice President - Legal Affairs
                               and General Counsel
                          North American Vaccine, Inc.
                            12103 Indian Creek Court
                           Beltsville, Maryland 20705
                                 (301) 419-8500

            (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)

                          Copies of correspondence to:
                           Thomas F. Cooney, III, Esq.
                           Sidney R. Smith, III, Esq.
                           Kirkpatrick & Lockhart LLP
                         1800 Massachusetts Avenue, N.W.
                                  Second Floor
                           Washington, D.C. 20036-1800



<PAGE>



                                EXPLANATORY NOTE


      North  American   Vaccine,   Inc.  (the   "Registrant")   is  filing  this
registration statement to de-register  $46,175,000 in aggregate principal amount
of 6.50%  Convertible  Subordinated  Notes ("Notes")  issued under an Indenture,
dated May 7, 1996,  between the  Registrant  and Marine Midland Bank, as Trustee
(the "Trustee") and an indeterminate number of shares of the Registrant's no par
value  common stock  ("Shares")  issuable  upon  conversion  of such Notes.  The
Registrant  initially registered the Notes and an indeterminate number of Shares
pursuant to a  registration  statement on Form S-3 filed with the Securities and
Exchange Commission on November 1, 1996 ("Registration Statement").  The Company
registered  $86.25  million in  aggregate  principal  amount of the Notes and an
indeterminate  number of Shares issuable upon conversion of the Notes for resale
under the Registration Statement.

      The Company wishes to de-register  the remaining Notes and Shares issuable
thereunder  as the Notes and the Shares became  eligible for resale  pursuant to
Rule 144(k) of the Securities Act of 1933, as amended ("Securities Act"), on May
7, 1998.

















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<PAGE>


                                   SIGNATURES

      Pursuant to the requirements of the Securities Act of 1933, the Registrant
has duly caused this post-effective  amendment to its Registration  Statement to
be signed on its behalf by the undersigned,  thereunto duly  authorized,  in the
City of Beltsville, State of Maryland, on June 24, 1998.

                                          NORTH AMERICAN VACCINE, INC.


                                          By:    /s/ Sharon Mates
                                                 -----------------
                                          Name:  Sharon Mates
                                          Title: President

      Pursuant to the  requirements  of the  Securities Act of 1933, as amended,
this post-effective  amendment to the Registration  Statement has been signed by
the following persons or by their designated  attorney-in-fact in the capacities
and on the dates indicated.


SIGNATURE                     TITLE                       DATE


/s/ Sharon Mates
- ------------------------      President                   June 24, 1998
Sharon Mates, Ph.D.


/s/ Lawrence J. Hineline
- ------------------------      Vice President-Finance      June 24, 1998
Lawrence J. Hineline


Majority of the Board of Directors


- ------------------------                                  June __, 1998
Francesco Bellini, Ph.D.*


- ------------------------
Alain Cousineau*                                          June __, 1998



- ------------------------
Jonathan Deitcher*                                        June __, 1998



- ------------------------
Denis Dionne*                                             June __, 1998



- ------------------------
Neil W. Flanzraich*                                       June __, 1998


- ------------------------
Phillip Frost, M.D.*                                      June __, 1998


- ------------------------ 
Lyle Kasprick*                                            June __, 1998  


                                       3

<PAGE>


                                                                         
                                                                         
- ------------------------ 
Sharon Mates, Ph.D.                                       June __, 1998  
                                                                         

- ------------------------ 
Francois Legault*                                         June __, 1998  
                                                                         
                                                                         
- ------------------------                                  
Gervais Dionne                                            June __, 1998  
                                                                         
                                                                         
- ------------------------                                  
Richard C. Pfenniger, Jr.*                                June __, 1998  
                                                          
                                                                         
                                                                         
                                                                         
                                                          

*By:/s/ Sharon Mates
    -----------------------
    Sharon Mates, Ph.D, as
    attorney-in-fact






















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