NORTH AMERICAN VACCINE INC
DEF 14A, 1998-04-20
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  SCHEDULE 14A

                            SCHEDULE 14A INFORMATION
          Proxy Statement Pursuant to Section 14(a) of the Securities
                              Exchange Act of 1934
                               (Amendment No. __)

Filed by Registrant [X]

Filed by a Party other than the Registrant [   ]

Check the appropriate box:

      [   ] Preliminary Proxy Statement
      [   ] Confidential, for Use of the Commission Only (as permitted by
            Rule 14a-6(e)(2))
      [ X ] Definitive Proxy Statement
      [   ] Definitive Additional Materials
      [   ] Soliciting Material Pursuant to ss.240.14a-11(c) or ss.240.14a-12


                          North American Vaccine, Inc.
               --------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

                          North American Vaccine, Inc.
               --------------------------------------------------
      (Name of Person(s) Filing Proxy Statement, if other than Registrant)

Payment of Filing Fee (Check the appropriate box):

      [ X ] No fee required.
      [   ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and
            0-11:

            1)    Title  of  each  class  of  securities  to  which  transaction
                  applies:
                          ------------------------------------------------------

            2)    Aggregate number of securities to which transaction applies:

                  --------------------------------------------------------------

            3)    Per  unit  price  or other  underlying  value  of  transaction
                  computed  pursuant  to  Exchange  Act Rule 0-11 (set forth the
                  amount on which the filing is calculated and state how it was
                  determined):
                              --------------------------------------------------

            4)    Proposed maximum aggregate value of transaction: 
                                                                  --------------
            5)    Total fee paid:
                                 -----------------------------------------------

      [   ] Fee paid previously with preliminary materials.

      [   ] Check  box if  any part of the fee is offset as provided by Exchange
            Act Rule 0-11(a)(2) and identify the filing for which the offsetting
            fee  was  paid   previously.   Identify  the   previous   filing  by
            registration  statement number, or the Form or Schedule and the date
            of its filing.



<PAGE>


      1)    Amount Previously Paid:
                                   ---------------------------------------------

      2)    Form, Schedule or Registration Statement Number:
                                                            --------------------
      3)    Filing Party:
                         -------------------------------------------------------

      4)    Date Filed:
                       ---------------------------------------------------------






                                      -2-

<PAGE>
                             NORTH AMERICAN VACCINE, INC.
                               12103 INDIAN CREEK COURT
                          BELTSVILLE, MARYLAND 20705 U.S.A.
                              -------------------------

                       NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
                               TO BE HELD MAY 20, 1998
                              -------------------------

      NOTICE IS HEREBY  GIVEN that the 1998 Annual  Meeting of  Shareholders  of
North American Vaccine,  Inc., a Canadian  corporation (the "Company"),  will be
held at 275 Armand-Frappier  Boulevard,  Laval, Quebec, Canada on Wednesday, May
20, 1998 commencing at 9:00 a.m., local time.

      THE PURPOSES of the Annual Meeting will be:

      1.    To elect the Board of Directors for the ensuing year;
      2.    To approve the Company's 1997 Share Option Plan;
      3.    To appoint Arthur Andersen LLP as independent  public accountants of
            the Company; and
      4.    To consider  and act upon any other  matter that may  properly  come
            before,   or  incident  to  the  conduct  of,  the  meeting  or  any
            adjournment thereof.

      All shareholders are cordially  invited to attend the Annual Meeting.  The
record date for determining  those  shareholders  entitled to vote at the Annual
Meeting  is April 1, 1998.  A review of the  Company's  operations  for the year
ended  December 31, 1997 will be presented.  The Company's 1997 Annual Report to
Shareholders  (including audited financial statements) is enclosed.  The meeting
will be subject to adjournment as the shareholders present in person or by proxy
may determine.

                                          By Order of the Board of Directors,

                                          Daniel J. Abdun-Nabi
                                          SECRETARY
April 20, 1998

IMPORTANT--WHETHER  OR NOT YOU PLAN TO ATTEND THE ANNUAL MEETING IN PERSON,  YOU
CAN HELP IN THE PREPARATION FOR THE ANNUAL MEETING BY FILLING IN AND SIGNING THE
ENCLOSED PROXY CARD AND PROMPTLY RETURNING IT IN THE ENCLOSED  ENVELOPE.  IF YOU
ARE UNABLE TO ATTEND,  YOUR SHARES  WILL BE VOTED AS DIRECTED BY YOUR PROXY.  IF
YOU DO ATTEND THE MEETING, YOU MAY VOTE YOUR SHARES EVEN THOUGH YOU HAVE SENT IN
YOUR PROXY CARD.


<PAGE>

                             NORTH AMERICAN VACCINE, INC.
                               12103 INDIAN CREEK COURT
                          BELTSVILLE, MARYLAND 20705  U.S.A.
                                  -------------------
                                    PROXY STATEMENT
                                  -------------------

      THIS PROXY STATEMENT IS FURNISHED IN CONNECTION  WITH THE  SOLICITATION BY
MANAGEMENT OF NORTH AMERICAN  VACCINE,  INC. (THE  "COMPANY") OF PROXIES FOR THE
1998 ANNUAL MEETING OF SHAREHOLDERS  OF THE COMPANY AND ANY ADJOURNMENT  THEREOF
(THE  "MEETING") TO BE HELD AT 275  ARMAND-FRAPPIER  BOULEVARD,  LAVAL,  QUEBEC,
CANADA  COMMENCING AT 9:00 A.M.,  LOCAL TIME, ON WEDNESDAY,  MAY 20, 1998.  This
Proxy  Statement,  together with the  accompanying  proxy and the Company's 1997
Annual Report to Shareholders (including audited financial statements), is first
being sent or given to the Company's  shareholders  on  approximately  April 20,
1998.

      The  cost  of  soliciting  proxies  will  be  borne  by the  Company.  The
solicitation  of proxies by mail may be  followed by  personal  solicitation  of
certain  shareholders  by officers or regular  employees of the  Company.  Proxy
materials  will  also be  distributed  through  brokers,  custodians  and  other
nominees or fiduciaries to beneficial  owners of the Company's Common Stock. The
Company  expects to  reimburse  such  persons for their  charges and expenses in
connection with this distribution.

      Each proxy that is properly  executed  and  returned  will be voted for or
against  or  withheld  from  voting  on any  ballot  that may be  called  for in
accordance with the instructions contained in that proxy. IF NO INSTRUCTIONS ARE
GIVEN,  SUCH PROXY WILL BE VOTED FOR THE ELECTION OF THE COMPANY'S  NOMINEES FOR
DIRECTOR,  THE  APPROVAL  OF THE  COMPANY'S  1997  SHARE  OPTION  PLAN,  AND THE
APPOINTMENT  OF  ARTHUR  ANDERSEN  LLP  AS  THE  COMPANY'S   INDEPENDENT  PUBLIC
ACCOUNTANTS. THE ACCOMPANYING PROXY CONFERS DISCRETIONARY AUTHORITY WITH RESPECT
TO AMENDMENTS OR VARIATIONS TO THE MATTERS  IDENTIFIED IN THE NOTICE CALLING THE
MEETING  OR OTHER  MATTERS  THAT MAY  PROPERLY  COME  BEFORE  THE  MEETING,  AND
ACCORDINGLY,  IN THE EVENT THERE ARE ANY SUCH  AMENDMENTS OR VARIATIONS OR OTHER
MATTERS BROUGHT BEFORE THE MEETING OR ANY  ADJOURNMENT OR POSTPONEMENT  THEREOF,
ALL PROXIES WILL BE VOTED IN  ACCORDANCE  WITH THE JUDGMENT OF THE PERSONS NAMED
AS PROXIES.  A shareholder  may revoke his or her proxy at any time prior to its
exercise by (i) duly filing a written notice of revocation with the Secretary of
the Company,  (ii) duly executing and delivering a proxy bearing a later date to
the  Secretary of the Company,  (iii) voting in person at the Meeting or (iv) in
any other  manner  permitted  by law. For any written  notice of  revocation  or
later-dated  proxy  to be  effective,  it must  be  delivered  to the  Company's
registered  office  at any  time  up to and  including  the  last  business  day
preceding the day of the Meeting, or any adjournment thereof, or to the chairman
of the  Meeting  on the day of the  Meeting,  or any  adjournment  thereof.  The
Company's  registered  office is located at 1 Place  Ville  Marie,  40th  Floor,
Montreal, Quebec H3B 4M4, Canada.

      If a quorum is present,  the  affirmative  vote of a majority of the votes
actually cast at the Meeting,  in person or by proxy, is necessary to elect each
of the nominees for director,  to approve the  Company's  1997 Share Option Plan
and  to  appoint  Arthur  Andersen  LLP  as  the  Company's  independent  public
accountants  for the year ending December 31, 1998. For purposes of tallying the
number of votes  actually  cast at the  Meeting for the  election of  directors,
approval of the Company's 1997 Share Option Plan and  appointment of independent
public accountants, any vote "for," "against" or to "withhold" from voting shall
be tallied as a vote cast at the  Meeting.  Abstentions  and "broker  non-votes"
(I.E.,  shares held by brokers or nominees as to which (i) the broker or nominee

<PAGE>

does not have discretionary voting power under the applicable exchange rules and
(ii)  instructions  have not been  received  from the  beneficial  owners or the
persons entitled to vote such shares) will not be counted as votes actually cast
at the Meeting on any matter to which they relate. Under American Stock Exchange
rules, brokers and nominees will not have discretionary authority to vote on the
proposal to approve the  Company's  1997 Share Option Plan without  instructions
from  beneficial  owners or the persons  entitled to vote such shares.  Finally,
abstentions will, and "broker non-votes" will not, be treated as shares that are
present and  entitled  to vote for  purposes of  determining  the  presence of a
quorum.

      In accordance with the Company's By-laws,  the stock transfer records were
compiled at the close of  business on April 1, 1998,  the record date set by the
Board of Directors for determining the  shareholders  entitled to notice of, and
to vote at, the Meeting and any adjournment  thereof.  On that date,  there were
32,050,618  outstanding shares of the Company's Common Stock. The holders of the
outstanding shares at the close of business on April 1, 1998 will be entitled to
one vote for each share held by them as of such date.

                                 ELECTION OF DIRECTORS
                                   (PROPOSAL  NO. 1)

      Eleven (11)  directors,  comprising the entire  membership of the Board of
Directors  of the  Company,  are to be  elected  at the  Meeting.  The  Board of
Directors has  nominated  the persons  listed below for election as directors of
the  Company.  If a quorum is present,  an  affirmative  vote of the majority of
votes actually cast at the Meeting is required to elect each director.

            Name                       Age(1)        Position
            ----                       ------        --------

          Neil W. Flanzraich........    54      Director; Chairman
          Francesco Bellini, Ph.D...    50      Director; Vice Chairman
          Phillip Frost, M.D........    61      Director; Vice Chairman
          Sharon Mates, Ph.D........    45      Director; President
          Alain Cousineau...........    56      Director
          Jonathan Deitcher.........    51      Director
          Denis Dionne..............    48      Director
          Lyle Kasprick.............    65      Director
          Francois Legault..........    41      Director
          Richard C. Pfenniger, Jr..    42      Director
          Gervais Dionne, Ph.D......    52      Nominee for Director

      --------------------------
      (1)   As of April 1, 1998.

      The  Company's  directors  are  elected  at  each  annual  meeting  of the
Company's  shareholders  and serve until the next annual meeting of shareholders
or until their  respective  successors are duly elected and qualified,  or their
prior resignation or removal. There are no family relationships among any of the
executive  officers  or  directors  of  the  Company.   Under  the  terms  of  a


                                      -2-
<PAGE>

Shareholders'  Agreement,  the Company's  principal  shareholders have agreed to
vote together for directors. See "Certain Transactions."  Background information
regarding each of nominees for director is set forth below.

      NEIL W.  FLANZRAICH:  Director  of the  Company  since  October  1989  and
Chairman since January 1995;  Shareholder with law firm of Heller Ehrman White &
McAuliffe and Chairman of the Life Sciences  Group of that firm since  September
1995;  General Counsel,  Senior Vice President and Secretary of Syntex (U.S.A.),
Inc. (pharmaceutical  company), a subsidiary of Roche Holding Ltd., from January
1995 to August  1995;  General  Counsel  from  January  1992 to  December  1994,
Co-General  Counsel  from  August 1987  through  January  1992,  and Senior Vice
President   from  June  1981  to  December   1994  of  Syntex   Corporation,   a
pharmaceutical  company  acquired  by  Roche  Holding  Ltd.  at the end of 1994;
Director  of IVAX  Corporation  ("IVAX")  (pharmaceutical  company)  since 1997;
Director of Whitman  Educational  Group, Inc. (operator of degree and non-degree
granting  post-secondary schools) since 1997; and Director of LXR Biotechnology,
Inc. (biotechnology company) since 1997.

      FRANCESCO BELLINI,  PH.D.:  Director of the Company since October 1989 and
Vice Chairman since June 1991;  President since September 1986,  Chief Executive
Officer since October 1986 and Director  since  September 1986 of BioChem Pharma
Inc. ("BioChem") (pharmaceutical company).

      PHILLIP FROST,  M.D.:  Director of the Company since October 1989 and Vice
Chairman since December 1990;  Chairman of the Board and Chief Executive Officer
of IVAX since 1987 and  President  from July 1991 to January  1995;  Chairman of
Whitman  Education  Group,  Inc.  since  1992;   Director  of  Northrop  Grumman
Corporation  (aerospace  company)  since 1996;  Vice  Chairman  and  Director of
Continucare  Corp.  (health-care  management)  since  1996;  a  trustee  of  the
University  of Miami since 1983;  and a member of the Board of  Governors of the
American Stock Exchange since 1992.

      SHARON MATES, PH.D.: Director of the Company since October 1989; President
of the Company since  February  1990; and member of the Board of Visitors of the
University of Maryland Biotechnology Institute since 1997.

      ALAIN COUSINEAU:  Director of the Company since October 1989;  Chairman of
the Board of Groupe SECOR Inc.  (management  consultants in corporate  strategic
planning)  since  February 1993 and President  from  September  1985 to February
1993;  Partner of Groupe SECOR Inc.  since July 1983;  Director of Bioniche Inc.
(biopharmaceutical  company) since September 1996 and MPACT Immedia  Corporation
(electronic  commerce software and services company) since January 1997, both of
which are public companies trading on the Toronto and Montreal Stock Exchanges.

      JONATHAN DEITCHER:  Director of the Company since February 1990;  Director
and Vice President of RBC Dominion  Securities  (securities  investment  dealer)
since  May  1984;  and  Director  of  Renaissance   Energy  Ltd.  (oil  and  gas
exploration)  since  1982 and  Vincor  International  Inc.  (wine  producer  and
retailer) since November 1993, both of which are public companies trading on the
Toronto Stock Exchange.

      DENIS DIONNE:  Director of the Company  since  October 1989;  President of
Societe financiere  d'innovation inc.  (Sofinov),  a high technology  investment
fund that is a subsidiary  of La Caisse de depot et  placement du Quebec,  since
April 1996;  and Senior  Vice  President,  Economic  Development  and  Strategic
Investments  from 1995 to March 1996,  and Senior Vice  President,  Security and


                                      -3-
<PAGE>

Investment  from 1988 to March 1996, of Fonds de Solidarite des  Travailleurs du
Quebec, an investment fund.

      LYLE  KASPRICK:  Director of the Company  since  October 1989 and Chairman
from June 1991 to January 1995;  private  investor since March 1988;  and, since
June 1993, a member of the Board of Directors  and the  Investment  Committee of
the University of North Dakota Foundation.

      FRANCOIS LEGAULT:  Executive Vice President,  Investments and Subsidiaries
of BioChem since February 1997; Senior Vice President,  Finance,  Administration
and  Treasurer  of  BioChem,  from  February  1993 to  February  1997;  and Vice
President, Finance and Treasurer of BioChem from 1987 to February 1993.

      RICHARD C.  PFENNIGER,  JR.:  Director  of the Company  since 1992;  Chief
Executive Officer and Vice Chairman of Whitman Education Group, Inc. since March
1997 and Director since 1992;  Chief Operating  Officer of IVAX from May 1994 to
March 1997;  Senior Vice President -- Legal Affairs and General  Counsel of IVAX
from 1989 to May 1994 and  Secretary  from 1990 to April 1994;  and  Director of
NaPro BioTherapeutics Inc. since 1993.

      GERVAIS DIONNE, PH.D.: Executive Vice President,  Research and Development
of BioChem since November 1994; President and Chief Executive Officer of BioChem
Therapeutics Inc.  (pharmaceutical company) from February 1993 to November 1994;
Vice  President,  Research and  Development  of BioChem from  September  1986 to
November 1994; Director of BioChem since 1991; Director of BioChem  Therapeutics
Inc. since 1993; Director of GeneChem  Technologies  (investment fund) since May
1997;  and Director of Briana  Bio-Tech Inc.  since December 1997, a health care
company that is trading on the Vancouver Stock Exchange.

      The Board of Directors has established the following committees. The Board
of Directors has not established a standing nominating committee.

      EXECUTIVE   COMMITTEE  -  The  Executive   Committee  is  responsible  for
exercising the authority of the Board of Directors between meetings of the Board
of Directors consistent with the limitations imposed by law. The current members
of this committee are Neil Flanzraich,  Francesco Bellini, Phillip Frost, Sharon
Mates and Rondi Grey, who is not standing for re-election to the Company's Board
of Directors.

      AUDIT  COMMITTEE - The Audit Committee is responsible for meeting with the
independent public  accountants and  representatives of management to review the
scope and results of audits, the  appropriateness of accounting  principles used
in financial  reporting,  and the adequacy of financial and operating  controls.
The current members of the Audit Committee are: Lyle Kasprick,  Francois Legault
and Richard Pfenniger.

      COMPENSATION  COMMITTEE - The  Compensation  Committee is responsible  for
establishing  executive  compensation  programs,   granting  options  under  the
Company's stock option plans and  interpreting and  administering  the Company's
option plans.  The current  members of the  Compensation  Committee  are:  Alain
Cousineau, Jonathan Deitcher and Denis Dionne.



                                      -4-
<PAGE>

      During 1997, the Board of Directors of the Company held five meetings, the
Executive Committee held no meetings, the Audit Committee held four meetings and
the  Compensation  Committee  held six  meetings.  All  members  of the Board of
Directors  attended at least 75% of their Board and Committee  meetings combined
during the last fiscal year, except for Francesco Bellini and Denis Dionne.

      Additional  nominations  for  director  may be made  from the floor at the
Meeting.  In case any of  these  nominees  should  become  unavailable  for such
election  for  any  reason  presently  unknown,  the  proxy  holders  will  have
discretionary  authority  under  the  proxy  to vote for a  suitable  substitute
nominee.

      COMPENSATION OF DIRECTORS

      Employee directors do not receive  additional  compensation for serving on
the Board of Directors. Non-employee directors received no cash compensation for
their  service  as  directors,  except as  described  below.  Directors  receive
reimbursement  for the expenses that they incur in performing  their services as
directors.

      Non-employee  directors have automatically received annual grants of stock
options  on  January 1 of each year  under the 1995  Non-Employee  Director  and
Senior Executive Stock Option Plan (the "1995 SESOP").  Accordingly,  on January
1, 1997, each non-employee  director  received an option to acquire:  (i) 20,000
shares of the  Company's  Common Stock where the  non-employee  director was the
Chairman of the Board or Vice  Chairman of the Board;  (ii) 5,000  shares of the
Company's  Common Stock for all other  non-employee  directors;  and (iii) 5,000
shares of Company's Common Stock for each committee of the Board of Directors on
which  non-employee  directors (other than the Chairman and Vice Chairman of the
Board) serve.  These options were all granted to such non-employee  directors at
an exercise  price of $24.375 per share,  the fair market value of the Company's
Common Stock on January 1, 1997,  the date of grant.  These options will vest in
three equal annual installments commencing on the January 1st following the date
of the grant.  No current  executive  officer  has  received,  or is entitled to
receive, options under the 1995 SESOP.

      Neil Flanzraich,  the Chairman of the Board,  received a total of $100,000
for the 1997  calendar  year for his  duties  performed  in that  capacity.  The
Company  maintains  on behalf of the  directors  and  officers  of the Company a
directors' and officers'  liability  insurance policy. For the policy year ended
February 28,  1998,  the premium paid by the Company for a policy with a covered
limit of $20 million was  approximately  $331,260,  with a  deductible  of up to
$200,000  per  claim.  No  allocation  of  premium  was made in  respect  of the
directors as a group or the officers as a group.





                                      -5-
<PAGE>



                          IDENTIFICATION OF SENIOR MANAGEMENT

      The following  table  identifies the senior  management of the Company and
the positions  that they hold.  Officers of the Company are elected by the Board
of  Directors at the annual  meeting  thereof to hold office for the term of one
year, and until successors are elected and qualified, or their prior resignation
or removal.

<TABLE>
<CAPTION>


              Name                                   Age(1)                        Position(s)
              ----                                   ------                        -----------
<S>                                                    <C>       <C>                             
       Sharon Mates, Ph.D. (2)(3).................     45        Director; President
       Arthur Y. Elliott, Ph.D. (3)...............     62        Senior Vice President -- Operations and Chief Operating Officer
       Daniel J. Abdun-Nabi (3)...................     43        Senior Vice  President  -- Legal  Affairs  and  General  Counsel;
                                                                 Secretary
       Wayne Morges, Ph.D. (3)....................     51        Vice President -- Quality/Regulatory Affairs
       Stephen N. Keith, M.D., M.S.P.H. (3) ......     45        Vice President -- Marketing and Sales
       Edward Arcuri, Ph.D. ......................     47        Vice President -- Manufacturing Operations
       Iver Heron, M.D., D.Sci....................     56        Vice President -- Research
       Joan D.S. Fusco, Ph.D. ....................     42        Vice President -- Business Development
       Lawrence J. Hineline (3)...................     41        Vice President -- Finance
</TABLE>

       (1)   As of April 1, 1998.
       (2)   See background  description  under heading  "Election of Directors"
             above.
       (3)   These  persons are  "executive  officers" for purposes of the rules
             and regulations of the Securities and Exchange Commission.

      Background  information  regarding each of the Company's senior management
is set forth below.

      ARTHUR Y. ELLIOTT,  PH.D.:  Senior Vice  President -- Operations and Chief
Operating  Officer of the Company since March 1994;  and, from 1978 to 1994, Dr.
Elliott was with Merck & Co. (pharmaceutical  company) holding various positions
including:  Executive  Director,  Biological  Operations;   Executive  Director,
Quality Control; Senior Director, Biologics; Director, Biological Manufacturing;
and Manager, Viral Vaccines and Veterinary Services.

      DANIEL J.  ABDUN-NABI:  Senior Vice President -- Legal Affairs and General
Counsel of the Company since  February  1990;  and Secretary of the Company from
June 1991.

      WAYNE MORGES, PH.D.: Vice President --  Quality/Regulatory  Affairs of the
Company since January 1995;  Vice President --  Manufacturing  Operations of the
Company from June 1994 to January  1995;  and from 1981 to 1994,  Dr. Morges was
with Merck & Co.  holding  various  positions  including:  Senior  Director  and
Responsible  Head,  Biological  Quality Control;  Director,  Biological  Quality


                                      -6-
<PAGE>

Control;  Manager,  Hepatitis  Vaccines and Recombinant  Products;  and Manager,
Biological Quality Control Technical Services.

      STEPHEN N. KEITH, M.D., M.S.P.H.: Vice President -- Marketing and Sales of
the Company since August 1995; from 1990 to 1995, Dr. Keith was with Merck & Co.
holding various positions including:  Senior Director,  Merck-Medco Managed Care
Division;  Senior  Customer  Manager,  U.S.  Human Health  Division;  and Senior
Director, Corporate Public Affairs.

      EDWARD ARCURI,  PH.D.:  Vice President -- Manufacturing  Operations of the
Company  since  January  1995;  and from March  1991 to  December  1994,  Senior
Director, Biological Manufacturing for Merck & Co.

      IVER HERON, M.D., D.SCI.:  Vice President -- Research of the Company since
October  1996;  Director of  International  Medical  Affairs of the Company from
March 1996 to October 1996; Head of Bacterial  Vaccines  Department,  Research &
Development at Statens  Seruminstitut ("SSI") (Denmark's national center for the
prevention  and control of infectious  diseases and congenital  disorders)  from
1993 to  January  1996  and  Scientific  Head  of  Vaccine  Department,  BCG and
Department of Biological Standardization at SSI from 1982 to 1993.

      JOAN D.S.  FUSCO,  PH.D.:  Vice  President -- Business  Development of the
Company since January 1997; Director of Business Development of the Company from
1995 to January 1997;  Manager of Business  Development of the Company from 1993
to 1994; from 1991 to 1992, Dr. Fusco served in various  scientific and research
positions with the Company.

      LAWRENCE J.  HINELINE:  Vice  President  -- Finance of the  Company  since
November 1993; Controller of the Company from December 1990 to November 1993.



                                      -7-
<PAGE>



                       SECURITY OWNERSHIP OF CERTAIN BENEFICIAL
                                 OWNERS AND MANAGEMENT

      The following table sets forth certain information provided to the Company
or contained in filings with the Securities and Exchange  Commission (the "SEC")
regarding the beneficial ownership of shares of the Company's Common Stock as of
February  27,  1998 by (i)  each  person  who is  known  by the  Company  to own
beneficially,  or  exercise  control  or  direction  over,  more  than 5% of the
outstanding  shares of the Company's Common Stock, (ii) all current directors of
the Company,  (iii) all nominees for director,  (iv) each of the Named  Officers
(as  defined  below  in the  section  entitled  "Executive  Compensation-Summary
Compensation Table") and (v) all current directors and executive officers of the
Company as a group. Unless otherwise indicated,  each person has sole voting and
investment  power with respect to the shares  specified  opposite  such person's
name.
<TABLE>
<CAPTION>


       Name Of Beneficial Owner                            Number Of Shares                        Percent Of Class
       ------------------------                            ----------------                        ----------------
       <S>                                                 <C>                                     <C>

BioChem Pharma Inc. ...........................            13,236,926(1)                               38.8%
  275 Armand-Frappier Blvd
  Laval, Quebec H7V 4A7
Frost-Nevada, Limited Partnership .............             3,767,859(2)                               11.1%
  c/o Phillip Frost, M.D
  IVAX Corporation
  4400 Biscayne Blvd
  Miami, Florida 33137
Phillip Frost, M.D. (3)(4) ....................             5,825,276(2)(5)                            17.1%
  c/o IVAX Corporation
  4400 Biscayne Blvd
  Miami, Florida 33137
Delphi Asset Management .......................             2,489,225(6)                                7.8%
  485 Madison Avenue
  New York, New York 10022
Denver Investment Advisors LLC ................             1,768,900(7)                                5.5%
  1225 17th Street, 26th Floor
  Denver, Colorado 80202
Neil W. Flanzraich (3)(4) .....................               241,561(5)(8)                              *
Francesco Bellini, Ph.D. (3)(4) ...............                95,199(5)(9)                              *
Alain Cousineau (3)(4) ........................                39,999(5)                                 *
Jonathan Deitcher (3)(4) ......................                74,999(5)                                 *
Denis Dionne (3)(4) ...........................                29,999(5)(10)                             *
Rondi R. Grey (3) .............................                 9,999(5)                                 *
Lyle Kasprick (3)(4) ..........................               564,993(5)                                1.8%


                                      -8-
<PAGE>

       Name Of Beneficial Owner                            Number Of Shares                        Percent Of Class
       ------------------------                            ----------------                        ----------------

Francois Legault (3)(4) .......................                 3,333(5)(9)                              * 
Richard C. Pfenniger, Jr. (3)(4) ..............                74,685(5)(11)                             * 
Gervais Dionne, Ph.D. (4) .....................                    --(9)                                 * 
Sharon Mates, Ph.D. (3)(4)(12) ................               519,463(5)(13)                            1.6%
Arthur Y. Elliott, Ph.D. (12) .................               163,750(5)(13)                             *
Daniel J. Abdun-Nabi (12) .....................               351,116(5)(13)(14)                        1.1%
Wayne Morges, Ph.D. (12) ......................                63,000(5)(13)                             *
Stephen N. Keith, M.D., M.S.P.H. (12) .........                55,459(5)(13)                             *
All directors and executive officers as a group
  (16 persons) ................................             8,224,475(2)(5)(10)(11)(13)(14)            23.2%
</TABLE>


- -------------------------
       *  Indicates less than one percent.

     (1)  The amount shown includes:  1,000,000 shares of the Company's Series A
          Preferred  Stock,  which are convertible  into 2,000,000 shares of the
          Company's  Common Stock,  and 57,812 shares that may be purchased upon
          the exercise of stock options.

     (2)  1,767,859   of  these  shares  are  held  by   Frost-Nevada,   Limited
          Partnership  ("Frost-Nevada"),  which has sole voting and  dispositive
          power with respect to such shares.  Also includes  1,000,000 shares of
          the Company's  Series A Preferred  Stock,  which are convertible  into
          2,000,000 shares of the Company's Common Stock,  held by Frost-Nevada.
          Dr.  Frost is the sole  shareholder  and a  director  of  Frost-Nevada
          Corporation,  the  general  partner of  Frost-Nevada,  and is the sole
          limited partner of Frost-Nevada. Consequently, Dr. Frost may be deemed
          to be the beneficial owner of all such shares held by Frost-Nevada.

     (3)  A director of the Company.

     (4)  A nominee for director of the Company.

     (5)  Includes,  where  applicable,  shares that may be  purchased  upon the
          exercise of stock options presently  exercisable or exercisable within
          60 days of February 27, 1998 as follows: 59,999 shares with respect to
          Drs. Frost and Bellini;  49,999 shares with respect to Mr. Flanzraich;
          29,999  shares with  respect to each of Messrs.  Cousineau,  Deitcher,
          Denis  Dionne and  Pfenniger;  9,999  shares with respect to Ms. Grey;
          176,999 shares with respect to Mr. Kasprick; 3,333 shares with respect
          to Mr.  Legault;  323,481  shares with respect to Dr.  Mates;  162,500
          shares with respect to Dr. Elliott; 222,133 shares with respect to Mr.
          Abdun-Nabi;  61,918 shares with respect to Dr.  Morges;  54,998 shares
          with  respect to Dr.  Keith;  and 105,000  shares with  respect to one
          unnamed executive officer.



                                      -9-
<PAGE>


  (6) Reflects aggregate  beneficial ownership of shares of the Company's Common
      Stock  held by Delphi  Asset  Management  ("Delphi")  in its  capacity  as
      investment advisor, according to its Schedule 13G dated February 17, 1998.
      Delphi has sole voting power over 1,565,800 shares of the Company's Common
      Stock and sole  dispositive  power over 2,489,225  shares of the Company's
      Common Stock.

 (7)  Reflects aggregate  beneficial ownership of shares of the Company's Common
      Stock held by Denver  Investment  Advisors  LLC ("DIA") in its capacity as
      investment advisor, according to its Schedule 13G dated February 11, 1998.
      DIA has sole voting power over  1,158,600  shares of the Company's  Common
      Stock and sole  dispositive  power over 1,768,900  shares of the Company's
      Common Stock.

 (8)  Although an officer of the general partner of Frost-Nevada, Mr. Flanzraich
      disclaims beneficial ownership of the shares of the Company's Common Stock
      beneficially owned by Frost-Nevada.

 (9)  Although  a  director  and/or  officer of  BioChem,  the named  individual
      disclaims beneficial ownership of the shares of the Company's Common Stock
      beneficially owned by BioChem.

 (10) 26,666 stock  options are subject to a prior  agreement  between Mr. Denis
      Dionne and his former  employer,  whereby Mr. Dionne must  exercise  these
      options  at  his  former  employer's   direction  and  then  transfer  the
      underlying  shares of Company Common Stock to his former  employer at cost
      (exercise price).

(11)  Includes 34,686 shares held jointly by Mr. Pfenniger and his wife.

(12)  A Named Officer of the Company.

(13)  Includes, where applicable,  approximately 2,515, 1,250, 2,411, 1,083, 461
      and 1,444  shares  issued under the  Company's  401(k) Plan and Trust as a
      matching  contribution  by the Company to the  retirement  accounts of Dr.
      Mates, Dr. Elliott, Mr. Abdun-Nabi,  Dr. Morges, Dr. Keith and one unnamed
      executive officer, respectively.

(14)  Includes  40,000  shares held by Mr.  Abdun-Nabi's  spouse,  for which Mr.
      Abdun-Nabi disclaims beneficial ownership.


SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

      Section  16(a) of the  Securities  Exchange  Act of 1934,  as amended (the
"1934 Act"),  requires the  Company's  executive  officers  and  directors,  and
persons who own more than ten percent of the  Company's  Common  Stock,  to file
initial  reports of ownership  and reports of changes in ownership  with the SEC
and the  American  Stock  Exchange  (the  "AMEX"),  the  exchange  on which  the
Company's Common Stock is listed for trading. Executive officers,  directors and
greater than ten-percent  shareholders  (collectively,  the "Reporting Persons")
are  required  by SEC  regulations  to furnish  the  Company  with copies of all
Section 16(a) forms they file.



                                      -10-
<PAGE>

      Based  solely on  review of the  copies  of such  forms  furnished  to the
Company,  and written  representations  by the  Reporting  Persons,  the Company
believes that during the year ended  December 31, 1997, all Section 16(a) filing
requirements  applicable  to the  Reporting  Persons  were met,  except that one
monthly  report,  covering four  transactions,  was not timely filed by Jonathan
Deitcher, a director of the Company.

COMPARATIVE STOCK PERFORMANCE

      The graph below  compares the  cumulative  total  return of the  Company's
Common Stock (as traded on the AMEX) against the cumulative  total return of the
S&P 500  Composite  Stock  Index and the AMEX  Biotechnology  Index for the five
years ended December 31, 1997.

      The phrase  "total  cumulative  return"  assumes that $100 was invested on
December 31, 1992 in the  Company's  Common Stock and in each index and that all
dividends were reinvested during the specified periods. The price performance of
the Company's  Common Stock shown below should not be viewed as being indicative
of future performance.


                 COMPARISON OF FIVE-YEAR CUMULATIVE TOTAL RETURN
                     NORTH AMERICAN VACCINE, INC., S&P 500
                          AND AMEX BIOTECHNOLOGY INDEX

[STOCK PERFORMANCE GRAPH INDICATING THE PLOT POINTS LISTED BELOW:

                             1992   1993  1994  1995  1996   1997
                             ----   ----  ----  ----  ----   ----

North American Vaccine, Inc. 100    109    83   140   241    246
S&P 500 Composite Index      100    110   112   153   189    252
AMEX Biotechnology Index     100     68    48    78    85     95]

      The  graph  above  shall  not  be  deemed  to be  soliciting  material  or
incorporated by reference by any general  statement  incorporating  by reference
this  Proxy  Statement  into any filing  under the  Securities  Act of 1933,  as
amended (the "1933 Act"), or the 1934 Act, except to the extent that the Company
specifically  incorporates  this  information by reference,  and it shall not be
otherwise deemed filed under such acts.



                                      -11-
<PAGE>



                            EXECUTIVE COMPENSATION

SUMMARY COMPENSATION TABLE

      The following table sets forth the cash and non-cash compensation for each
of the last three fiscal years  awarded to (1) the  President,  as the Company's
chief  executive  officer,  and (2)  the  four  other  most  highly  compensated
executive  officers  of the  Company  for  the  year  ended  December  31,  1997
(collectively, the "Named Officers").

<TABLE>
<CAPTION>
                                                                                                   Long-Term
                                                                                                 Compensation
                                                                                                 ------------
                                                             Annual Compensation                    Awards
                                                    -------------------------------------           ------
                                                                                                   Securities
                                                                                 Other Annual      Underlying            
    Name and                                        Salary         Bonus        Compensation(1)     Options          All Other
Principal Position                   Year            ($)            ($)               ($)             (#)          Compensation(2)
- ------------------                   ----            ---            ---               ---             ---          ---------------
<S>                                  <C>            <C>            <C>               <C>             <C>              <C>

Sharon Mates, Ph.D.                    1997        $350,000(3)        --               --            80,000            $5,374
  President                            1996         283,920         $50,000(4)         --               -0- (5)         5,224
                                       1995         273,000           --               --            75,000             4,754

Arthur Y. Elliott, Ph.D.               1997         283,000           --               --            37,500             5,374
  Senior Vice President-               1996         262,080           --               --               -0-             5,224
  Operations & Chief Operating         1995         252,000           --               --            75,000             4,754
  Officer

Daniel J. Abdun-Nabi                   1997         224,100           --               --            37,500(6)          5,374
  Senior Vice President-               1996         207,480           --               --               -0-             5,224
  Legal Affairs & General              1995         199,500           --               --            50,000             4,754
  Counsel

Wayne Morges, Ph.D.                    1997         215,700           --               --            25,000             5,374
  Vice President-                      1996         199,680           --               --               -0-             5,224
  Quality/Regulatory Affairs           1995         192,000           --               --            25,000             4,754

Stephen N. Keith, M.D., M.S.P.H.       1997         207,800           --               --            25,000             5,374
  Vice President-                      1996         192,400           --               --               -0-             5,224
  Marketing & Sales                    1995          67,242  (7)      --               --            70,000               172
</TABLE>


- -------------------------

(1)   For 1997,  1996 and  1995,  the  aggregate  amount  of such  Other  Annual
      Compensation  for each  Named  Officer is not  reportable  under SEC rules
      because  such  amount is the lesser of either  $50,000 or 10% of the total
      annual salary for each such Named Officer.



                                      -12-
<PAGE>

(2)   Amounts  of  All  Other   Compensation  for  1997  includes  (i)  matching
      contributions  made by the Company in fiscal  1997 to the Named  Officer's
      retirement account under the North American Vaccine,  Inc.  Retirement and
      Savings 401(k) Plan and Trust ($4,750 for each Named Officer) and (ii) the
      Company's cost  allocation of  supplemental  term life insurance ($624 for
      each Named Officer).  The matching 401(k)  contributions have been made in
      the form of the Company's Common Stock and are included in the table under
      the  heading  "Security   Ownership  of  Certain   Beneficial  Owners  and
      Management."

(3)   Includes  $35,000  adjustment  to 1997 salary that was  determined
      and paid during 1998.

(4)   Bonus determined and paid in 1997 for performance during 1996.

(5)   In 1996,  Dr.  Mates was granted an  18-month  extension  of a  previously
      granted option to purchase  270,000  shares of the Company's  Common Stock
      under the Company's  former Share Option Plan, which option was originally
      scheduled to expire on October 30, 1996. No other terms of the option were
      changed. The extension was effective as of April 14, 1996.

(6)   In addition to the grant of a new option to purchase  37,500 shares of the
      Company's  Common Stock under the  Company's  1995 Share Option Plan,  Mr.
      Abdun-Nabi  was  granted a five-year  extension  of a  previously  granted
      option to purchase  150,000 shares of the Company's Common Stock under the
      Company's former Share Option Plan, which option was originally  scheduled
      to expire on March 18,  1997.  No other terms of the option were  changed.
      The extension was effective as of March 6, 1997.

(7)   Dr. Keith was first employed with the Company in August 1995.






                                      -13-
<PAGE>



OPTION GRANTS IN LAST FISCAL YEAR

      The following table sets forth certain information  concerning  individual
grants and  extensions  of stock options made to the Named  Officers  during the
year ended December 31, 1997. The Company has not granted any stock appreciation
rights ("SARs").

<TABLE>
<CAPTION>
                                                 INDIVIDUAL  GRANTS                             
                         ----------------------------------------------------------------          POTENTIAL REALIZABLE VALUE
                                                                                                     AT ASSUMED ANNUAL RATES
                          NUMBER OF          PERCENT OF                                            OF STOCK PRICE APPRECIATION
                         SECURITIES         TOTAL OPTIONS                                               FOR OPTION TERM(1)
                         UNDERLYING          GRANTED TO          EXERCISE                          ---------------------------
                          OPTIONS           EMPLOYEES IN         OR BASE        EXPIRATION
   NAME                  GRANTED(2)         FISCAL YEAR           PRICE           DATE                  5%               10%
   ----                  ----------         -----------           -----           ----                  --               ---
                            (#)                                   ($/SH)
<S>                         <C>                   <C>            <C>            <C>                <C>               <C>

Sharon Mates                 80,000               12.3%           $19.00        07/09/2007        $  955,920        $2,422,489

Arthur Y. Elliott            37,500                5.8%            20.25        04/14/2007           477,567         1,210,248

Daniel J                    150,000(3)(4)         23.1%            11.125       03/18/2002         3,187,392         6,063,845
   Abdun-Nabi                37,500                5.8%            20.25        04/14/2007           477,567         1,210,248
                            -------               -----                                            ----------        ----------
                            187,500               28.8%                                            3,664,959         7,274,093

Wayne Morges                 25,000                3.8%            20.25        04/14/2007           318,378           806,832
  
Stephen N. Keith             25,000                3.8%            20.25        04/14/2007           318,378           806,832
</TABLE>

- --------------------

    (1)   Gains are reported net of the option exercise price,  but before taxes
          associated  with exercise.  These amounts  represent  certain  assumed
          rates of appreciation only, based on the per share market price on the
          date of grant and an annual  appreciation  at the rate stated  through
          the  expiration  date of the option.  Actual  gains,  if any, on stock
          option  exercises  are  dependent  on the  future  performance  of the
          Company's   Common   Stock,   overall   market   conditions   and  the
          optionholder's  continued  employment  through the vesting period. The
          amounts reflected in this table may not necessarily be achieved.

    (2)   Except for the extension of the option for 150,000  shares  previously
          granted to Mr.  Abdun-Nabi  (see footnote 3), all options were granted
          under the  Company's  1995 Share  Option Plan at fair market value and
          vest in three equal installments commencing one year after the date of
          grant.



                                      -14-
<PAGE>

    (3)   This  represents  a  five-year  extension  of a  previously
          granted  option  under the  Company's  former  Share Option
          Plan,  which was  originally  scheduled  to expire on March
          18, 1997.  No other terms of the option were  changed.  The
          option  is   exercisable   in  full.   The   extension  was
          effective  as of March 6, 1997 and the fair market value of
          the Company's Common Stock was $19.875 as of such date.

    (4)   This  option is  governed  by the  Company's  former  Share
          Option  Plan.  In  accordance  with the terms of that plan,
          upon   the   occurrence   of   certain   major    corporate
          transactions  in which the Company is not the  surviving or
          acquiring  corporation,  or in which the Company  becomes a
          wholly-owned  subsidiary  of  another  corporation,  if any
          option   granted   thereunder  is  then   outstanding   and
          unexercised and the shares  thereunder are not converted or
          exchanged for  securities of another  corporation,  then an
          optionholder  is entitled to receive,  in exchange  for the
          cancellation of an option,  a cash payment equal to the net
          difference  between the fair market value of the  Company's
          Common Stock and the option  exercise  price.  On the other
          hand,  if the  transaction  specifically  provides  for the
          conversion or exchange of the shares under any  outstanding
          and  unexercised  portion  of an option for  securities  of
          another corporation,  the Company's Compensation Committee,
          in its sole discretion,  may either (i) permit, in exchange
          for the  cancellation of an option, a cash payment equal to
          net  difference  between  the  fair  market  value  of  the
          Company's  Common  Stock and the option  exercise  price or
          (ii) adjust the shares  issuable under any  outstanding and
          unexercised  options in a manner not inconsistent  with the
          terms of the transaction.






                                      -15-
<PAGE>



AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
AND FISCAL YEAR-END OPTION VALUES

  The  following  table  summarizes  the  value  realized  by any  of the  Named
Officers,  who exercised options under the Company's former Share Option Plan in
fiscal 1997, as well as the number and value of unexercised options held by each
Named  Officer as of December 31, 1997.  As the Company has not issued any SARs,
no SARs were exercised.

<TABLE>
<CAPTION>
                                                            NUMBER OF SECURITIES                   VALUE OF UNEXERCISED
                                                           UNDERLYING UNEXERCISED                  IN-THE-MONEY OPTIONS
                                                         OPTIONS AT FISCAL YEAR-END                AT FISCAL YEAR-END (1)
                       SHARES                         -------------------------------        ------------------------------
                     ACQUIRED ON        VALUE
  NAME                 EXERCISE        REALIZED       EXERCISABLE       UNEXERCISABLE        EXERCISABLE      UNEXERCISABLE
  ----                 --------        --------       -----------       -------------        -----------      -------------
                         (#)              ($)            (#)               (#)                   ($)              ($)
<S>                     <C>              <C>            <C>               <C>                   <C>               <C>

  Sharon Mates           100,963     $1,173,002           319,037        105,000              $3,978,244           $751,563

  Arthur Y. Elliott           -0-            -0-          150,000         62,500               1,684,375            452,344

  Daniel J.
    Abdun-Nabi            23,700        327,363           219,633         54,167               2,966,553            360,160

  Wayne Morges                -0-            -0-           53,585         33,334                 740,460            209,382

  Stephen N. Keith            -0-            -0-           46,665         48,335                 603,728            419,084
</TABLE>

- ---------------------
    (1)   Values  based only on (i) the number of options for which the exercise
          price was equal to or less than  $24.9375  (the  closing  price of the
          Company's  Common Stock on the AMEX on December 31, 1997) and (ii) the
          difference  between  such  closing  price and such  options'  exercise
          price.


COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

      The following report of the Company's  Compensation Committee shall not be
deemed to be  soliciting  material or  incorporated  by reference by any general
statement  incorporating by reference this Proxy Statement into any filing under
the 1933 Act or the 1934 Act, except to the extent that the Company specifically
incorporates this information by reference, and it shall not be otherwise deemed
filed under such acts.




                                      -16-
<PAGE>



To the Company's Shareholders:

      The Compensation  Committee of the Company's Board of Directors is charged
with  reviewing  and  approving  the  compensation  of the  Company's  executive
officers,  as well as any  other  employees  earning  $130,000  or more per year
thereafter  (individually,   a  "Senior  Manager"  and,  collectively,   "Senior
Management");  provided,  however,  that the  President's  cash  compensation is
subject to final approval of the entire Board of Directors.  For these purposes,
compensation includes salaries,  benefits,  stock options and any other forms of
remuneration  approved by the  Compensation  Committee.  The  objectives  of the
Compensation  Committee's  compensation  program are  three-fold:  (i) to create
incentives to achieve outstanding corporate and individual performance,  (ii) to
align Senior  Management's  interests  with those of the Company's  stockholders
through  potential stock ownership and (iii) to assist the Company in attracting
and  retaining   qualified   management  by  providing   competitive  levels  of
compensation.

      COMPONENTS  OF  SENIOR  MANAGEMENT  COMPENSATION.  Consistent  with  these
objectives  and the  long-term  focus  required  at this stage of the  Company's
development,  the Compensation  Committee  adheres to the position that a Senior
Manager's  compensation  should  consist  of a  reasonable  cash  salary  to  be
supplemented by meaningful equity incentives in the form of stock option grants,
whose ultimate  value is tied to long-term  corporate  development  and enhanced
shareholder value.

      Salaries for Senior Management are determined  initially by evaluating the
responsibilities  of the position held and the experience of the individual,  as
well as by reference  to the  competitive  marketplace  for  management  talent.
Thereafter,  the  President,  with the  assistance  of other  members  of Senior
Management,  makes annual salary  recommendations for each Senior Manager to the
Compensation Committee.  The Compensation Committee reviews such recommendations
and makes such modifications as it deems appropriate. The Compensation Committee
sets final annual salaries, which take effect as of January 1 of each year.

      All Senior  Managers  establish  annual goals and  objectives  (subject to
their respective  supervisor's  approval) against which they are evaluated.  The
Compensation  Committee  also measures the  performance  of each Senior  Manager
against any increased  responsibilities assumed. Further adjustments are made to
reflect an assessment of the Company's  performance in relation to its strategic
and  operational  goals,  as well as with its economic  performance,  giving due
consideration to its stage of development. This assessment considers the quality
and measured  progress of the Company's  research and development  program,  its
manufacturing and related operations,  and regulatory approval process, together
with the success of strategic actions such as corporate financings, research and
development agreements, corporate alliances and similar relationships.  Based on
the  foregoing,  the  Compensation  Committee  agreed that salary  increases for
Senior  Managers  (other  than  the  Company's   President)  should  not  exceed
approximately  8.0% percent for fiscal 1997,  with one  exception to reflect the
assumption of increased responsibilities. Except as described below with respect
to the President's  compensation package, the Compensation Committee has not, to
date,  established specific performance goals or tied executive  compensation to
the achievement of specific performance goals.

      Stock option grants  represent a long-term  incentive  program designed to
link  Senior  Management  compensation  with  stockholder  value over  time.  In
recognition of the long time horizons  required for returns on  investments  and


                                      -17-
<PAGE>

strategic  decisions  in  development-stage  companies  competing in the vaccine
business,  these grants also serve to focus Senior Management's attention on the
Company's  long-term  needs.  Generally,  stock  options  are  awarded to Senior
Managers at the time that they join the Company and periodically thereafter. The
Compensation  Committee's intent is to immediately align the interests of Senior
Management  with those of the Company's  shareholders  through the initial stock
option  grant  and  then to  grant  options  only on an  intermittent  basis  in
furtherance of this philosophy,  taking into account the number of stock options
then held by each  Senior  Manager.  If  necessary  to retain a member of Senior
Management,  stock  option  grants  may  also  be  made in  amounts  that,  when
aggregated with the other forms of compensation mentioned above, will be, in the
Compensation Committee's subjective judgment, fair and competitive.

      Grants of stock options are generally made upon the recommendations of the
President;  however, the actual number of stock options granted is determined by
the  Compensation  Committee's  subjective  analyses  of each  Senior  Manager's
function, salary, length of service,  performance and value to the Company, with
no specific  weighting  given as to any of such factors.  All options granted to
Senior Managers are made at the then current market price. Options granted under
the 1995 Share Option Plan  generally  first become  exercisable  one year after
grant and vest over a three-year  period and expire ten years following the date
of grant. Generally, options may be exercised only so long as the optionee is an
employee of the Company or within the twelve-month period following  termination
of employment.

      As a matter of policy,  the Company  generally does not alter the terms of
previously granted options;  however, the Compensation Committee,  under unusual
circumstances  and  on  a  case-by-case   basis,   occasionally   considers  the
advisability of granting extensions of an option's exercise period. With this in
mind,  the  Compensation  Committee  did  extend  in  March  1997 the term of an
expiring  stock  option  for  150,000  shares  of  the  Company's  Common  Stock
previously  granted to the  Company's  Senior Vice  President -- Legal Affairs &
General  Counsel for an  additional  five years.  As the  exercise  price of the
option was below the  then-current  market price for the Company's Common Stock,
the extension  caused the Company to recognize a one-time,  non-cash  expense of
approximately $1.3 million for financial,  but not tax, reporting  purposes.  In
the  judgment of the  Compensation  Committee,  the  five-year  extension of the
option's  term  was  appropriate  given  the  officer's  long-term  service  and
substantial contributions to the Company.

      PRESIDENT'S COMPENSATION. These same compensation policies were applied by
the  Compensation  Committee  for Dr.  Sharon  Mates,  who,  in the  capacity of
President,  serves as the Company's chief executive  officer.  In 1997 and 1998,
the Compensation Committee approved (1) a 1997 salary of $350,000, (2) a $50,000
cash  bonus for  performance  during  1996,  and (3) the grant of an option  for
80,000 shares of Common  Stock.  The  Compensation  Committee  recommended  this
compensation   after   evaluating,   among   other   things,   (i)  Dr.   Mates'
accomplishments during 1996 and 1997, (ii) the Company's performance in relation
to its strategic,  operational and economic  goals,  including the status of FDA
approval  for  Certiva(TM),  (iii) the  compensation  packages of officers  with
similar  responsibilities at selected biotechnology  companies as described in a
compensation consultant's report, adjusted to reflect aged data, (iv) the number
of options available for grant under the plan, and (v) past option awards to Dr.
Mates, with no specific weighting given to any of such factors.

      The  Company  is  generally  denied a  deduction  for  federal  income tax
purposes  for  compensation  over $1  million  paid in any  taxable  year to the
Company's  President or any of its four other most highly compensated  executive


                                      -18-
<PAGE>

officers. However, qualifying performanced-based  compensation is not subject to
the limitation if certain  requirements are satisfied.  Based on the rules under
the new law, the Company believes that compensation expenses associated with the
Company's  former  Share  Option Plan,  which  expired by its terms in 1995,  is
exempt from this $1 million cap. The  Company's  1995 Share Option Plan and 1995
Non-Employee  Director and Senior  Executive  Stock Option Plan,  as well as the
Company's  1997 Share Option Plan,  which will be considered for approval by the
Company's  shareholders  at the Meeting,  have been  designed to comply with the
requirements for deductibility under Section 162(m) of the Internal Revenue Code
of 1986, as amended.  Accordingly,  the Company does not expect  compensation to
any individual to be in excess of $1 million in fiscal 1997 for purposes of this
tax law. While the Company does not have a policy that requires all compensation
payable in fiscal 1998 and thereafter to be deductible under Section 162(m), the
Company does not expect  compensation  to any  individual  to be in excess of $1
million for fiscal 1998 and will endeavor,  whenever possible without distorting
incentives  for  performance  to  enhance  the  value of the  Company,  to cause
compensation to be structured so that all of it will be tax deductible.

      As the  Compensation  Committee  considers  it  important  to  retain  the
flexibility  to design  compensation  programs that are in the best interests of
the  Company  and  its   shareholders,   it  is  continually   evaluating  those
compensation   programs  and  procedures  with  respect  to  Senior  Management.
Accordingly, the Compensation Committee has engaged a compensation consultant to
advise the committee on, among other things,  a complete  compensation  program,
system and package for future compensation  determinations for Senior Management
as well as for directors.

April 2, 1998                             Compensation Committee

                                          Jonathan Deitcher, Chairman
                                          Alain Cousineau
                                          Denis Dionne


COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

      Through  January 29, 1997, the members of the  Compensation  Committee for
the Company's Board of Directors were Jonathan Deitcher,  Rondi Grey and Richard
Pfenniger.  After that date,  Alain  Cousineau  and Denis Dionne served with Mr.
Deitcher  on the  committee  for  the  remainder  of  fiscal  1997.  None of the
individuals  listed  above was or is a current  employee  or a former or current
officer of the Company or any of its subsidiaries.  Rondi Grey was the Corporate
Affairs Advisor to the President of BioChem until June 1997.  Richard  Pfenniger
served as the Chief Operating  Officer of IVAX through March 1997 and thereafter
as Chief Executive  Officer and Vice Chairman of Whitman  Education Group,  Inc.
("Whitman").

      Dr. Bellini is the President and Chief Executive  Officer,  as well as a
director,  of BioChem and serves as a member of BioChem's  Human Resources and
Compensation Committee.  Mr. Legault is Executive Vice President,  Investments
and  Subsidiaries  of  BioChem.  Dr.  Frost is the  Chairman  of the Board and
Chief  Executive  Officer of IVAX,  Mr.  Flanzraich is a director of IVAX, and
Mr.  Kasprick was a director of IVAX through  September 1997. Dr. Frost is the
Chairman,  and  Mr.  Flanzraich  is  a  director,  of  Whitman.  See  "Certain
Transactions"  for a description  of certain  transactions  relating to, among
others, Dr. Frost, IVAX, BioChem and the Company.



                                      -19-
<PAGE>



                              CERTAIN TRANSACTIONS

      The  transaction,  whereby  certain  vaccine  technologies  of BioChem and
American  Vaccine  Corporation,   the  predecessor  to  the  Company  ("American
Vaccine"),  were combined into the Company, was consummated on February 28, 1990
(the "Merger").  As a result of the Merger, BioChem currently holds Common Stock
of the Company, Series A Preferred Stock of the Company, and options to purchase
Common Stock,  which  options may only be exercised  when and to the extent that
the matching  options  issued to former option  holders of American  Vaccine are
first exercised.  In the Merger, BioChem issued shares to the Company,  together
with cash and  certain  vaccine  technologies.  In the  Merger,  the Company and
BioChem  granted  to each  other a  one-time  demand  registration  right  (with
expenses to be paid by the party exercising the registration  right) and certain
piggy-back  registration  rights. The piggy-back  registration rights expired on
January 17,  1995 and the demand  registration  right,  which was  scheduled  to
expire as of January 17, 1998,  was amended in January 1998 to extend that right
until January 17, 2001.

      A  shareholders'  agreement (the  "Shareholders'  Agreement") was executed
between Dr. Frost,  Frost-Nevada and IVAX (collectively,  the "Frost Group") and
BioChem as part of the Merger. Under the Shareholders' Agreement, both the Frost
Group and BioChem  agreed to nominate an equal number of directors  for election
to the Board of  Directors  of the Company,  and such  nominees  then select one
additional nominee satisfactory to both groups of nominees.  The Frost Group and
BioChem  agreed to vote all of their  respective  shares of Common  Stock of the
Company to elect to the Board of Directors all of the nominees so selected.  The
combination  of the  voting  power of the  Frost  Group  and  BioChem  under the
Shareholders'  Agreement gives them effective control of the Company and enables
them to determine  the policies and direct the  operations  of the Company.  The
Shareholders' Agreement also grants the Frost Group and BioChem mutual rights of
first refusal with respect to the sale, transfer or other similar disposition of
any of their  shares of the  Company's  Common  Stock,  the  Company's  Series A
Preferred  Stock or other  securities of the Company held directly or indirectly
by either of them.  Such  rights of first  refusal  do not  apply,  however,  to
transfers of such  securities by the Frost Group or BioChem to their  respective
affiliates.  The Shareholders' Agreement will terminate on February 28, 2000. In
addition,  in the event that either BioChem or the Frost Group ceases to hold an
aggregate of 50% or more of the Company's  Common Stock,  the Company's Series A
Preferred Stock and other Company  securities  owned by it on February 28, 1990,
the selling party will lose its rights of first refusal under the  Shareholders'
Agreement and the provisions thereunder regarding the nomination and approval of
nominees to the Board of Directors of the Company will lapse.

      In connection  with the Merger,  Frost-Nevada,  IVAX and a former  officer
(collectively, the "Indemnitees"),  all of whom beneficially owned, at the time,
more than 5% of the outstanding capital stock of American Vaccine,  entered into
an Indemnification Agreement with the Company (the "Indemnification Agreement"),
pursuant to which the Company  agreed to indemnify the  Indemnitees  against any
United States  federal,  state and local income tax  liabilities  that may arise
under  prescribed  "gain  recognition  agreements"  that  the  Indemnitees  were
required to file with the United States Internal  Revenue Service and that would
require the Indemnitees to recognize gain upon the occurrence of certain events.
Such gain  recognition  agreements  generally would require that the Indemnitees
recognize  gain (and file  amended tax  returns) if the Company  sells  American
Vaccine stock that it acquired as a result of the Merger or if American  Vaccine
sells all or substantially  all of its assets (other than in the ordinary course
of business)  during the period  commencing on the date of  consummation  of the


                                      -20-
<PAGE>

Merger and ending December 31, 2000. Under the  Indemnification  Agreement,  the
Company  agreed to (i) lend the  Indemnitees on an  interest-free  and after-tax
basis, an amount equal to the taxes to be paid with the amended tax returns, and
(ii) pay the Indemnitees, on an after-tax basis, any interest and penalties with
respect to the taxes to be paid with the amended returns. However,  repayment of
these  loans  will  only be  required  at the  time and to the  extent  that the
Indemnitees  receive  benefit  from the  resulting  increase in the tax basis of
their Common Stock or Series A Preferred  Stock.  There can be no assurance that
any such benefit  will be received.  Under the  Indemnification  Agreement,  the
Company's  directors  nominated  by the Frost Group,  with the  exception of Dr.
Frost, will not be precluded from voting upon a transaction that could give rise
to the Company's indemnification obligations to the Indemnitees. The affirmative
vote of 75% of all of the Company's  directors,  excluding  Dr.  Frost,  will be
required  to approve  any  transaction  that could  require  the  payment of any
indemnity  pursuant  to the  Indemnification  Agreement.  No  payments  would be
triggered under the Indemnification Agreement arising out of a tender offer for,
or a business combination involving, all of the Company's Common Stock.

      In 1997, the Company was  represented by law firm of Heller Ehrman White
& McAuliffe in certain matters.  Mr. Flanzraich,  Chairman of the Board of the
Company, is a member of that firm.


                APPROVAL OF THE COMPANY'S 1997 SHARE OPTION PLAN
                                (PROPOSAL NO. 2)

      The  Company's  1997 Share Option Plan (the "1997 Share Option  Plan") was
adopted by the Company's  Board of Directors at its regular  meeting on December
9, 1997, subject to the approval of the Company's  shareholders.  If a quorum is
present,  an  affirmative  vote of the  majority of votes  actually  cast at the
Meeting is required to approve the 1997 Share Option Plan.

      The 1997 Share Option Plan is designed to comply with the  requirements of
Rule 16b-3  promulgated under the 1934 Act, and the Company intends that options
granted  under the 1997 Share  Option Plan will  qualify for an exception to the
rule limiting the deductibility of executive  compensation  under Section 162(m)
of the Internal  Revenue Code of 1986, as amended (the "Code").  Section  162(m)
limits the  deductibility of compensation  over $1 million paid to the Company's
President and its four other most highly  compensated  executive officers unless
that  compensation  is   performanced-based   and  the  plans  under  which  the
compensation is paid are approved by the shareholders.  Shareholder  approval of
the 1997 Share Option Plan should permit  deductibility  under Section 162(m) of
the Code of compensation  attributable  to stock options.  The 1997 Share Option
Plan will not be put into effect if shareholder approval is not obtained.

      A summary  of the  essential  features  of the 1997 Share  Option  Plan is
provided  below,  but is qualified in its entirety by reference to the full text
of the 1997 Share  Option  Plan,  which is  attached  as Exhibit A to this Proxy
Statement.




                                      -21-
<PAGE>



DESCRIPTION OF THE 1997 SHARE OPTION PLAN

      PURPOSE.  The 1997 Share  Option  Plan is intended  to  contribute  to the
Company's  ability  to  attract  and retain  the best  available  personnel  for
positions of substantial responsibility,  to provide additional incentive to the
employees of the Company and its  subsidiaries  as well as  directors  and other
individuals who perform services for the Company,  and to promote the success of
the  Company's  business.  The 1997 Share  Option  Plan is not  qualified  under
Section 401(a) of the Code, and is not subject to any provisions of the Employee
Retirement Income Security Act of 1974, as amended ("ERISA").

      SHARES  AVAILABLE FOR ISSUANCE.  The 1997 Share Option Plan authorizes the
granting of options to purchase up to 5,000,000  shares of the Company's  Common
Stock (all or any of which may be incentive stock options). As of April 6, 1998,
the 5,000,000  shares reserved for issuance under the 1997 Share Option Plan had
an aggregate  market  value of  $83,437,500  (based on the closing  price of the
Company's  Common  Stock on the AMEX as of such date).  The shares  issued under
options  pursuant to the 1997 Share Option Plan will be newly issued or treasury
shares of Common  Stock.  No employee may receive  stock  options under the 1997
Share Option Plan in any calendar  year to purchase more than one percent of the
shares of Common  Stock  issued  and  outstanding  as of the  beginning  of that
calendar  year.  If an option  should  expire,  terminate  or  otherwise  become
unexercisable  for any  reason  without  having  been  exercised  in  full,  the
unpurchased  shares will become available for further grant under the 1997 Share
Option Plan.

      ADMINISTRATION.  The 1997 Share Option Plan is administered by a committee
of the Board of Directors (the "Committee"),  which must consist of at least two
directors  who  are  "non-employee   directors"  as  defined  under  Rule  16b-3
promulgated  under the 1934 Act and who are "outside  directors"  as defined for
purposes of Section  162(m) of the Code.  Subject to the  provisions of the 1997
Share Option Plan, the Committee has the  authority,  in its  discretion,  among
other  things,  (1) to grant  incentive  stock  options or  non-qualified  stock
options;  (2) to determine the fair market value of the Company's  Common Stock;
(3) to establish the duration of each Option  granted;  (4) to determine the per
share  exercise  price of each option  granted;  (5) to determine the persons to
whom, and the time or times at which, options shall be granted and the number of
shares  represented  by each option;  (6) to determine  the vesting  schedule of
options to be  granted  and to  accelerate  the  vesting  of any option  already
granted; (7) to determine whether the exercise price of or taxes relating to any
option may be paid in already owned shares and/or shares of the Company's Common
Stock then issuable upon the exercise of the option; (8) to prescribe, amend and
rescind  rules and  regulations  relating to the 1997 Share Option Plan;  (9) to
determine  the terms and  provisions of each option  granted  (which need not be
identical); (10) to accelerate or defer the exercise date of any option; (11) to
waive  or  amend  any  and  all  restrictions  and  conditions  of any  options,
including,  without  limitation,  extending  the  term  of any  option;  (12) to
authorize any person to execute on behalf of the Company any instrument required
to effectuate the grant of an option  previously  granted by the Committee;  and
(13) to interpret  the 1997 Share Option Plan and make all other  determinations
deemed  necessary or advisable for the  administration  of the 1997 Share Option
Plan. All decisions,  determinations  and  interpretations  of the Committee are
final and binding on all optionees.

      AWARD LIMITATIONS. The 1997 Share Option Plan provides for the issuance of
options  intended to be incentive  stock options  within Section 422 of the Code
and nonqualified  stock options not intended to meet the requirements of Section
422 of the Code.  Incentive  stock  options  may only be granted  to  employees,
including employees of the Company's subsidiaries,  and nonqualified options may


                                      -22-
<PAGE>

be granted to employees,  non-employee  directors,  independent  contractors and
agents of the Company and its subsidiaries;  provided,  however,  the Company is
not  permitted to grant  options  under the 1997 Share Option Plan to any person
who is a non-employee  director if such grant does not comply with Rule 16b-3 of
the  1934 Act or to any  person  who is a  Canadian  resident.  Incentive  stock
options that first  become  exercisable  in any calendar  year for shares with a
fair  market  value on the date of grant in excess of  $100,000  are  treated as
nonqualified stock options to the extent of such excess.

      TERM. The 1997 Share Option Plan will continue in effect until December 9,
2007, unless earlier terminated by the Committee. Each option granted may have a
term  of up to 10  years,  or such  shorter  time  as may be  determined  by the
Committee.  However,  with  respect to an incentive  stock option  granted to an
employee who,  immediately before the granting of the option, owns more than 10%
of the voting  power of all classes of stock,  the term of the  incentive  stock
option shall not exceed five years, or such shorter time as may be determined by
the Committee.

      OPTION  PRICE.  The per  share  exercise  price for the  shares  under the
options (both  incentive stock options and  nonqualified  stock options) will be
determined by the Committee;  however,  it may not be less than 100% of the fair
market  value of the Common  Stock on the date of grant  (except with respect to
substitute options issued with certain corporate transactions). Nonetheless, the
exercise price of any incentive  stock option granted to the holder of more than
10% of the voting  power of all classes of shares of the Company may not be less
than 110% of the fair market  value on the date of grant.  Fair market  value is
defined as the closing  price of the  Company's  Common  Stock on the  principal
securities exchange on which such stock is traded on the date of grant or, if no
sales were  reported on that date,  then on the last  preceding  date on which a
sale was  reported.  The optionee is required to pay for the shares to be issued
upon exercise of an option in cash,  check, or such other form and in such other
manner as the  Committee may accept,  which may include  shares of the Company's
Common Stock owned by the optionee. The options are exercisable at such time and
in accordance with the procedures specified in the option agreement.

      TERMINATION OF EMPLOYMENT.  In general, all outstanding options granted to
an employee  terminate  three months after the optionee ceases to be an employee
(or such longer period as determined by the Committee), except that such options
terminate (i) immediately (unless otherwise  determined by the Committee) if the
optionee's employment is terminated for willful or gross misconduct,  including,
without  limitation,   breach  of  fiduciary  duty  and  (ii)  36  months  after
retirement. With respect to options granted to persons other than employees, the
Committee  shall have the  authority  to determine  in its sole  discretion  the
ability of that optionee to exercise an option  following  termination of his or
her relationship with the Company.

      The  options  granted  under  the  1997  Share  Option  Plan  may  not  be
transferred  in any  manner  other  than  by will or the  laws  of  descent  and
distribution or pursuant to a qualified  domestic  relations order as defined by
the Code or Title I of ERISA, and, during the optionee's  lifetime,  the options
may be exercised only by the optionee or his or her legal representative. In the
event that an optionee  dies,  an option may be  subsequently  exercised  by the
legal  representatives of the optionee's estate during the remaining term of the
option, but only to the extent the optionee was entitled to exercise such option
as of the date of death.



                                      -23-
<PAGE>

      ADJUSTMENTS.  The number of shares of Common Stock covered by  outstanding
options,  the number of shares of Common  Stock  available  to be granted in the
future  under  the 1997  Share  Option  Plan,  the  exercise  price per share of
outstanding  options  and the  maximum  number of shares  of Common  Stock  with
respect to which  options may be granted to any  employee in any  calendar  year
will be  proportionately  adjusted for any increase or decrease in the number of
issued shares of Common Stock  resulting from a stock split or stock dividend or
any other  increase or decrease in the number of issued  shares of Common  Stock
effected  without  receipt  of  consideration  by the  Company.  In  event  of a
dissolution or liquidation, outstanding options will terminate upon consummation
of such transaction, unless otherwise provided by the Committee. In addition, in
the event of an  acquisition  by the  Company of another  corporation  where the
Company  assumes under the 1997 Share Option Plan  outstanding  stock options or
similar  obligations of such  corporation,  the number of shares available under
the 1997 Share  Option  Plan shall be  appropriately  increased  to reflect  the
number of shares under such options or other obligations assumed.

      CHANGE OF CONTROL. In the event of a change of control of the Company, the
exercisability  of each option shall be  automatically  accelerated so that each
such option outstanding shall, immediately prior to the specified effective date
of a change of control,  becomes fully exercisable for all shares subject to the
option.  The events that trigger an acceleration of the options'  exercisability
are: (i) a third party  acquires  direct or indirect  ownership of fifty percent
(50%) or more of the combined  voting power of the  Company's  then  outstanding
securities  of the  Company;  (ii) any  election  has occurred of persons to the
Board of Directors of the Company that causes  two-thirds of the Company's Board
of  Directors  to consist of persons  other than (A) persons who were members of
the  Company's  Board of  Directors  on January 1, 1997 and (B) persons who were
nominated by the  Company's  Board of  Directors  for election as members of the
Company's Board of Directors at a time when two-thirds of the Company's Board of
Directors  consisted  of  persons  who were  members of the  Company's  Board of
Directors on January 1, 1997; provided,  however,  that any person nominated for
election by the Board of  Directors of the Company at least  two-thirds  of whom
constituted  persons described in clauses (A) and/or (B) above or by persons who
were themselves  nominated by such Board shall,  for this purpose,  be deemed to
have been  nominated  by a Board  composed  of persons  described  in clause (A)
above;  or (iii) the  shareholders  of the  Company  approve  (A) any  statutory
consolidation, merger or amalgamation of the Company in which the Company is not
the surviving corporation (other than a merger or amalgamation of the Company in
which the holders of shares of Common Stock  immediately  prior to the merger or
amalgamation have the same proportionate  ownership of the surviving corporation
immediately after the merger or amalgamation),  or (B) any sale, lease, exchange
or other transfer (in one  transaction or a series of related  transactions)  of
all, or substantially all, of the assets of the Company to an entity that is not
a wholly-owned subsidiary of the Company.

      AMENDMENTS  TO THE PLAN AND OPTIONS.  The  Committee  may amend,  suspend,
discontinue or terminate the 1997 Share Option Plan in such respects as it deems
advisable,  but will not be able to amend the 1997  Share  Option  Plan  without
shareholder approval where such approval is required in order to comply with the
Canada Business  Corporations Act, the rules of the exchange on which the Common
Stock is  listed,  Section  162(m) of the  Code,  or any  other  requirement  of
applicable  law  or  regulation.  In  addition,  the  Committee  may  waive  any
conditions or rights under,  or amend,  suspend,  discontinue or terminate,  any
option and/or the terms of any  corresponding  option  agreement.  No amendment,
suspension,  discontinuance  or termination of the 1997 Share Option Plan or any
option granted thereunder shall,  without an optionee's  consent,  impair any of
the rights of the optionee  under any option  previously  granted under the 1997
Share Option Plan.



                                      -24-
<PAGE>

      EFFECTIVE  DATE OF THE PLAN.  The 1997 Share Option Plan is subject to the
approval by the  affirmative  vote of a majority of the votes  actually cast, in
person or by proxy,  at the Meeting.  If the 1997 Share Option Plan is approved,
it will become effective as of December 9, 1997, the date of its adoption by the
Board of  Directors.  The 1997 Share  Option  Plan will  terminate  if it is not
approved by the shareholders within twelve months after the date of its adoption
by the Company's  Board of Directors.  All options  granted prior to shareholder
approval are granted  conditional upon shareholder  approval of the Plan, except
to the extent that any option agreement  expressly  provides for the continuance
of the options granted as non-plan,  nonqualified  options  notwithstanding  the
termination of the Plan.

SUMMARY OF U.S. FEDERAL INCOME TAX CONSEQUENCES

      INCENTIVE STOCK OPTIONS.  The Company intends that certain options granted
under the 1997 Share Option Plan will qualify as incentive stock options meeting
the requirements of Section 422 of the Code. The tax  consequences  attendant to
the grant and exercise of incentive stock options are discussed in general terms
below.

      The grant of an incentive stock option has no immediate federal income tax
consequences to the optionee or to the Company. In addition,  the exercise of an
incentive  stock option  generally  has no  immediate  tax  consequences  to the
Company or to the optionee.  Under the alternative minimum tax provisions of the
Code,  however,  the  exercise of an  incentive  stock option would result in an
increase in the  optionee's  alternative  minimum  taxable  income  equal to the
excess of the fair market  value of the shares at the time of exercise  over the
exercise price.

      If an optionee  holds the shares  acquired  pursuant to the exercise of an
incentive stock option for the required  holding period (I.E.,  the later of two
years  from the  date of grant  and one  year  from the date of  exercise),  the
optionee generally  recognizes  long-term capital gain or loss upon a subsequent
sale of the shares in the amount of the difference  between the amount  realized
upon the sale and the exercise price of the option.  The Company is not entitled
to a deduction in connection  with the grant or exercise of the incentive  stock
option or the sale of shares acquired pursuant to such exercise.

      If,  however,  an optionee  exercises an incentive  stock option more than
three months after termination of employment (twelve months after termination in
the case of disability) or disposes of the shares prior to the expiration of the
required  holding  period,  the option  will be treated  for tax  purposes  as a
nonqualified stock option, such that the optionee generally  recognizes ordinary
income (subject to wage withholding and employment taxes) equal to the excess of
the fair market  value of the shares on the date of exercise (or the proceeds of
disposition,  if less) over the exercise price, and the Company is entitled to a
corresponding  deduction  if  the  compensation   constitutes  an  ordinary  and
necessary business expense, the limitations of Section 162(m) of the Code do not
apply,  and  applicable  reporting  requirements  are  satisfied.  If the amount
realized upon such a disposition  exceeds the fair market value of the shares on
the date of  exercise,  the excess  generally  would be treated as  long-term or
short-term capital gain.

      NONQUALIFIED  STOCK OPTIONS.  The grant of a nonqualified stock option has
no immediate  federal  income tax  consequences  to the optionee or the Company.
Upon the  exercise of a  nonqualified  stock  option,  the  optionee  recognizes
ordinary income (subject to wage withholding and employment  taxes) in an amount
equal to the  excess  of the fair  market  value  of the  shares  on the date of


                                      -25-
<PAGE>

exercise over the exercise price, and the Company is entitled to a corresponding
deduction if the  compensation  constitutes  an ordinary and necessary  business
expense,  the  limitations  of  Section  162(m)  of the Code do not  apply,  and
applicable reporting requirements are satisfied. The optionee's tax basis in the
shares is the exercise  price plus the amount of ordinary  income  recognized by
the optionee,  and the  optionee's  holding period will commence on the date the
shares are  received.  Upon a  subsequent  sale of the  shares,  any  difference
between the  optionee's  tax basis in the shares and the amount  realized on the
sale generally is treated as capital gain or loss.

      TAXATION OF  LONG-TERM  CAPITAL  GAINS.  The  Taxpayer  Relief Act of 1997
substantially  changed the tax treatment of capital gains for  individuals.  For
capital assets (including stock received upon exercise of options) held for more
than 18 months,  the maximum rate of tax on net capital gains is 20%. A 10% rate
applies to taxpayers in the 15% ordinary  income tax bracket.  Capital  gains on
assets  held for more than 12 months  but less than 18 months are taxed at a 28%
rate. For holding periods  beginning  after December 31, 2000,  gains on capital
assets held for more than five years are subject to a reduced rate.  The 20% and
10% rates discussed above are reduced to 18% and 8%, respectively.

      The foregoing summary of the effect of U.S. federal income taxation to the
optionee and the Company under the 1997 Share Option Plan does not purport to be
complete.  In  addition,  this summary  does not discuss the  provisions  of the
income tax laws of any state or foreign  country  in which the  participant  may
reside.  Participants should consult their own tax advisors to determine the tax
consequences to them of participating in the 1997 Share Option Plan.

CURRENT PARTICIPATION UNDER THE 1997 SHARE OPTION PLAN

      As of April 6, 1998,  no  options  had been  granted  under the 1997 Share
Option Plan, so all 5,000,000 shares reserved  thereunder  remained eligible for
grant.  It is not possible to identify  the persons who will be granted  options
under the 1997 Share Option Plan, the number of shares subject to any option, or
the terms and conditions of any option, because these matters will be determined
by the Committee in the future.  As of April 6, 1998,  six  executive  officers,
approximately 270 employees,  four non-employee  directors who are not residents
of Canada,  and an  indeterminate  number of independent  contractors and agents
were eligible to receive stock options under the 1997 Share Option Plan.

      THE BOARD OF  DIRECTORS  RECOMMENDS A VOTE FOR PROPOSAL 2 (APPROVAL OF THE
      COMPANY'S 1997 SHARE OPTION PLAN).


                  APPOINTMENT OF INDEPENDENT PUBLIC ACCOUNTANTS
                                (PROPOSAL NO. 3)

      The Board of Directors has  recommended  that the  Company's  shareholders
appoint  Arthur  Andersen  LLP as the  independent  public  accountants  for the
Company to examine its  consolidated  financial  statements  for the year ending
December  31,  1998.  Arthur  Andersen  LLP  was  previously  appointed  by  the
shareholders as the independent public accountants for the Company for the years
ended December 31, 1989 through 1997. The Company's audited consolidated balance
sheets as of December 31, 1997 and 1996 and audited  consolidated  statements of
operations, shareholders' equity and cash flows for the years ended December 31,
1997, 1996 and 1995 have been submitted to the  shareholders as part of the 1997
Annual   Report  to   Shareholders   accompanying   this  Proxy   Statement.   A
representative of Arthur Andersen LLP will be present at the Meeting,  will have


                                      -26-
<PAGE>

the right to make a statement  if he or she so desires and will be  available to
respond to appropriate questions by the shareholders.

      THE BOARD OF DIRECTORS  RECOMMENDS A VOTE FOR PROPOSAL 3  (APPOINTMENT  OF
      ARTHUR ANDERSEN LLP AS INDEPENDENT PUBLIC ACCOUNTANTS).


                                 OTHER BUSINESS

      The  Company is not aware of any other  matters  that may come  before the
Meeting.  It is the intention of the persons named in the enclosed proxy to vote
the proxy in  accordance  with  their  best  judgment  if any other  matters  do
properly  come  before the  Meeting.  Whether  or not you attend the  Meeting in
person, please fill in, date and sign the enclosed proxy and return it promptly.
If you attend the Meeting,  you may, of course, vote your shares even though you
may have previously sent in your proxy.


                               1999 ANNUAL MEETING

      In the event that  shareholders of the Company intend to make proposals to
be presented at the Company's 1999 Annual Meeting of  Shareholders to be held in
May 1999 (or such date as shall be designated by the Board of  Directors),  such
proposals, to be included in the 1999 Proxy Statement and form of proxy, must be
received  by the  Company at its  principal  executive  offices by no later than
December 31, 1998.


APPROVAL BY THE BOARD OF DIRECTORS

The contents and sending of this Proxy Statement have been approved by the Board
of Directors of North American Vaccine, Inc.



/S/ DANIEL J. ABDUN-NABI
- ----------------------------------
DANIEL J. ABDUN-NABI, SECRETARY



                                      -27-
<PAGE>



                                                                      EXHIBIT A

                          NORTH AMERICAN VACCINE, INC.
                             1997 SHARE OPTION PLAN


      1. PURPOSES.  The purposes of this 1997 Share Option Plan (the "Plan") are
to attract and retain the best available  personnel for positions of substantial
responsibility,  to provide additional incentive to the Employees of the Company
or its Subsidiaries or Parent, as well as to directors and other individuals who
perform services for the Company or its  Subsidiaries or Parent,  and to promote
the success of the Company's  business.  Options granted hereunder may be either
Incentive Stock Options or Nonqualified Stock Options,  at the discretion of the
Committee and as reflected in the terms of the written Option agreement.

      2. DEFINITIONS. As used herein, the following definitions shall apply:

      "CODE" shall mean the Internal  Revenue Code of 1986, as amended,  and all
rules and regulations promulgated thereunder,  as each of the statute, rules and
regulations may be amended from time to time.

      "COMMON  SHARES"  shall mean the  common  shares,  no par value,  of the
Company.

      "COMPANY"   shall  mean  North  American   Vaccine,   Inc.,  a  Canadian
corporation.

      "COMMITTEE"  shall mean the committee  appointed by the Company's Board of
Directors in accordance with Section 4(a) of the Plan.

      "CONTINUOUS  STATUS  AS  AN  EMPLOYEE"  shall  mean  the  absence  of  any
interruption  or termination  of service as an Employee.  Service as an Employee
shall not be  considered  interrupted  for purposes of the Plan,  in the case of
sick leave,  military  leave,  or any other  personal,  family and medical leave
permitted and duly approved in accordance with the Company's  written  policies,
as well as any other bona fide leave of absence approved by the Committee.

      "EMPLOYEE" shall mean any person,  other than a resident of Canada, who is
employed by the Company or any Parent or Subsidiary. The payment of a director's
fee by the Company shall not be sufficient  to  constitute  "employment"  by the
Company.

      "EXCHANGE  ACT"  shall  mean the  Securities  Exchange  Act of 1934,  as
amended.

      "FAIR MARKET  VALUE" of a Common  Share shall mean,  as of any given date,
the closing sales price of a Common Share on such date on the principal national
securities exchange on which the Common Shares are then traded or, if the Common
Shares are not then traded on a national securities exchange, the average of the
high and low trading prices of the Common Shares on such date as reported on the
Nasdaq;  provided,  however,  that,  if there were no sales  reported as of such
date,  Fair Market  Value shall be computed as of the last date  preceding  such
date on which a sale was reported; provided, further, that, if any such exchange
or  quotation  system is closed on any day on which Fair  Market  Value is to be
determined,  Fair  Market  Value  shall  be  determined  as of  the  first  date
immediately  preceding such date on which such exchange or quotation  system was



<PAGE>

open for trading.  In the event the Common Shares are not admitted to trade on a
securities exchange or quoted on Nasdaq, the Fair Market Value of a Common Share
as of any given date shall be as determined in good faith by the Committee.

      "INCENTIVE  STOCK OPTION" shall mean a share option intended to qualify as
an "incentive stock option" within the meaning of Section 422 of the Code.

      "NONQUALIFIED  STOCK  OPTION"  shall mean a share  option not  intended to
qualify as an "incentive  stock option" within the meaning of Section 422 of the
Code.

      "OPTION" shall mean an option to purchase  Common Shares granted  pursuant
to the Plan.

      "OPTIONED SHARES" shall mean the Common Shares subject to an Option.

      "OPTIONEE" shall mean the recipient of an Option.

      "PARENT" shall mean a "parent corporation" of the Company,  whether now or
hereafter existing, as defined in Section 424(e) of the Code.

      "RULE 16B-3" shall mean Rule 16b-3 promulgated by the U.S.  Securities and
Exchange Commission under the Exchange Act or any successor rule.

      "SHARE" shall mean a Common Share,  as adjusted in accordance with Article
12 of the Plan.

      "SUBSIDIARY" shall mean a "subsidiary corporation" of the Company, whether
now or hereafter existing, as defined in Section 424(f) of the Code.

      3.  SHARES.  Subject to the  provisions  of  Article  12 of the Plan,  the
maximum  aggregate  number  of  Shares  that  may be  issued  under  the Plan is
5,000,000  (any or all of which may be Incentive  Stock  Options).  The Optioned
Shares shall be newly issued or treasury  Common Shares.  The grant of an Option
pursuant to the Plan shall  reduce the number of Shares that  thereafter  may be
available for future grants under the Plan; provided, however, that if an Option
should  expire,  terminate  or  otherwise  become  unexercisable  for any reason
without having been exercised in full, the unpurchased  Shares that were subject
thereto shall, unless the Plan shall have been terminated,  become available for
further  grant under the Plan.  Exercise of an Option in any manner shall result
in a  decrease  in a number of  Shares  that  thereafter  may be  available  for
purchase  under  the  Option by the  number of Shares as to which the  Option is
exercised.

      4.    ADMINISTRATION.

      (a) COMMITTEE.  The Plan at all times shall be administered by a Committee
appointed by the Company's  Board of Directors.  The Committee  shall consist of
not less than two members of the Company's Board of Directors, each of whom is a
"non-employee  director"  as defined in Rule 16b-3 and an "outside  director" as
defined for purposes of Section 162(m) of the Code.



                                      -2-
<PAGE>

      (b) POWERS OF THE  COMMITTEE.  Subject to the  provisions of the Plan, the
Committee shall have the authority,  in its  discretion:  (i) to grant Incentive
Stock Options or Nonqualified  Stock Options;  (ii) to determine the Fair Market
Value of the Common  Shares;  (iii) to  establish  the  duration  of each Option
granted;  (iv) to determine  the  exercise  price per Share of the Options to be
granted;  (v) to determine the persons to whom,  and the time or times at which,
Options  shall be  granted  and the number of Shares to be  represented  by each
Option;  (vi) to determine the vesting  schedule of Options to be granted and to
accelerate the vesting of any Option already granted; (vii) to determine whether
the  exercise  price of or taxes  relating  to an Option  may be paid in already
owned Shares and/or Shares then issuable upon the exercise of the Option; (viii)
to prescribe, amend and rescind rules and regulations relating to the Plan; (ix)
to determine  the terms and  provisions  of each Option  granted  under the Plan
(which need not be  identical);  (x) to accelerate or defer the exercise date of
any Option;  (xi) to waive or amend any and all  restrictions  and conditions of
any Options,  including,  without limitation,  extending the term of any Option;
(xii) to authorize any person to execute on behalf of the Company any instrument
required  to  effectuate  the  grant  of an  Option  previously  granted  by the
Committee;  and (xiii) to interpret  the Plan and make all other  determinations
deemed necessary or advisable for the administration of the Plan.

      (c) EFFECT OF THE COMMITTEE'S DECISION. All decisions,  determinations and
interpretations of the Committee shall be final and binding on all Optionees. No
member of the Company's  Board of Directors or the Committee shall be liable for
any action or  determination  made in good faith with respect to the Plan or any
Option agreement.

      5. ELIGIBILITY.  Incentive Stock Options may be granted only to Employees.
Nonqualified Stock Options may be granted to Employees,  non-employee  directors
and  independent  contractors  and  agents  of  the  Company  or any  Parent  or
Subsidiary; provided, however, that Options may not be granted under the Plan to
(i) a  non-employee  director if such grant does not comply with  provisions  of
Rule 16b-3,  or (ii) any persons or entities  that are Canadian  residents.  Any
person who has been  granted an Option  may,  if he is  otherwise  eligible,  be
granted an additional Option or Options. Subject to the provisions of Article 12
of the Plan,  the maximum  number of Shares with respect to which Options may be
granted  under the Plan to any Employee in any calendar year is one percent (1%)
of the Common Shares issued and outstanding as of the beginning of such calendar
year.

      Except  as  otherwise  provided  under the Code,  to the  extent  that the
aggregate Fair Market Value of Common Shares for which  Incentive  Stock Options
(under all share  option  plans of the Company and of any Parent or  Subsidiary)
are  exercisable  for the first time by an  Employee  during any  calendar  year
exceeds One Hundred  Thousand U.S. Dollars  (US$100,000),  such Options shall be
treated as Nonqualified Stock Options. For purposes of this limitation,  (a) the
Fair Market Value of Common  Shares is  determined  as of the time the Option is
granted and (b) the limitation is applied by taking into account  Options in the
order in which they were granted.

      6. TERM OF PLAN. The Plan shall become  effective upon its adoption by the
Board of Directors of the Company; provided that, if the Plan is not approved by
the shareholders of the Company in accordance with Article 17 of the Plan within
twelve  (12)  months  after  the  date of  adoption  by the  Company's  Board of
Directors,  the Plan and any Options  granted  thereunder  shall  terminate  and
become null and void,  except to the extent that any Option agreement  expressly
provides  for the  continuance  of the Options  granted  thereby  (as  non-plan,
nonqualified options) notwithstanding the termination of the Plan. Unless sooner
terminated in accordance  with Article 14 of the Plan, the Plan shall  terminate
on  December  9,  2007,  except  that  the Plan  and the  Committee's  authority
thereunder  shall continue with respect to any Options then  outstanding.  After
such date, no further Options shall be granted under the Plan.



                                      -3-
<PAGE>

      7. TERM OF OPTION. The term of each Option granted to an Employee shall be
ten (10) years from the date of grant  thereof  or such  shorter  time as may be
determined by the Committee and set forth in the Option  agreement.  In the case
of Options granted to individuals who are not Employees, the term of each Option
shall be such term as may be determined by the Committee, not to exceed ten (10)
years.  However, in the case of an Incentive Stock Option granted to an Employee
who,  immediately  before the  Incentive  Stock  Option is granted,  owns shares
representing  more than ten percent  (10%) of the  combined  voting power of all
classes of shares of the  Company or any Parent or  Subsidiary,  the term of the
Incentive Stock Option shall be five (5) years from the date of grant thereof or
such shorter time as may be  determined  by the  Committee  and set forth in the
Option agreement.

      8.    EXERCISE PRICE AND CONSIDERATION.

      (a) The per Share exercise  price for the Shares to be issued  pursuant to
exercise of an Option shall be such price as is determined by the Committee, but
shall be subject to the following:

            (i) In the case of an  Incentive  Stock  Option:  (A)  granted to an
Employee who,  immediately before the grant of such Incentive Stock Option, owns
shares  representing  more than ten  percent  (10%) of the  voting  power of all
classes  of shares of the  Company or any  Parent or  Subsidiary,  the per Share
exercise  price shall be no less than one hundred ten percent (110%) of the Fair
Market  Value  per  Share on the date of  grant;  and (B)  granted  to any other
Employee,  the per Share  exercise  price  shall be no less than the Fair Market
Value per Share on the date of grant.

            (ii) In the  case of a  Nonqualified  Stock  Option,  the per  Share
exercise price shall be no less than the Fair Market Value per Share on the date
of grant.

      (b)  Notwithstanding  Section  8(a) of the Plan,  in the event the Company
substitutes an Option to replace a share option issued by another corporation in
connection  with  a  corporate  transaction,  such  as a  merger,  amalgamation,
consolidation,  acquisition  of  property  or  stock,  separation  (including  a
spin-off or other distribution of stock or property), reorganization (whether or
not such reorganization  comes within the definition of such term in Section 368
of the Code) or partial or complete  liquidation  involving the Company and such
other  corporation,  the  Committee  may  grant  substituted  Options  under the
provisions  of the Plan  replacing  old options  granted under a plan of another
party to such transaction.  The foregoing  adjustments and manner of application
of the  foregoing  provisions  shall be  determined by the Committee in its sole
discretion  (subject to the provisions of Section 424(a) of the Code in the case
of an Option that was intended to qualify as an  Incentive  Stock  Option).  Any
such adjustments may provide for the elimination of any fractional Common Shares
that might otherwise become subject to any Options.

      (c)  During the period  when an Option is  exercisable,  the Option may be
exercised,  in whole or in part,  by giving  written  notice of  exercise to the
Company (in form  acceptable to the Company)  specifying the number of Shares to
be  purchased.  Such  notice  shall be  accompanied  by  payment  in full of the
aggregate  exercise  price  of  the  Shares  to  be  purchased  in  cash,  check
(including,  without limitation,  payment in accordance with a cashless exercise
program under which,  if so  instructed  by the  Optionee,  Common Shares may be
issued directly to the Optionee's  broker or dealer upon receipt of the purchase
price in cash from the  broker or  dealer)  or such other form and in such other
manner as the  Committee  may  accept.  If and to the extent  determined  by the
Committee in its sole  discretion at or after grant,  payment in full or in part
may also be made in the form of Common  Shares duly owned by the  Optionee  (and
for  which  the  Optionee  has good  title,  free and  clear  of any  liens  and


                                      -4-
<PAGE>

encumbrances)  or by reduction in the number of Common Shares issuable upon such
exercise  based,  in each case, on the Fair Market Value of the Common Shares on
the date the  Option is  exercised.  No  Common  Shares  shall be  issued  until
payment, as provided herein, therefor has been made.

      9.    EXERCISE OF OPTION.

      (a)  PROCEDURE  FOR  EXERCISE.  Any  Option  granted  hereunder  shall  be
exercisable  at such  times and  under  such  conditions  as  determined  by the
Committee, including performance criteria with respect to the Company and/or the
Optionee, and as shall be permissible under the terms of the Plan. An Option may
not be  exercised  for a fraction  of a Share.  An Option  shall be deemed to be
exercised  when written  notice of such  exercise (in a form  acceptable  to the
Company)  has been  given to the  Company  in  accordance  with the terms of the
Option by the person  entitled to exercise  the Option and full  payment for the
Shares with  respect to which the Option is exercised  has been  received by the
Company.  Full  payment  may, as  authorized  by the  Committee,  consist of any
consideration and method of payment allowable under Section 8(c) of the Plan.

      (b) RIGHTS AS A SHAREHOLDER. Until the issuance, which in no event (except
as  provided  in Article 15 of the Plan) will be delayed  more than  thirty (30)
days  from the date that the  Company  receives  payment  in full  after  proper
exercise of the Option,  of the share  certificate  evidencing  the Shares to be
issued (as evidenced by the appropriate  entry on the books of the Company or of
a duly authorized transfer agent of the Company), no right to vote or to receive
dividends or any other rights as a  shareholder  shall exist with respect to the
Optioned Shares,  notwithstanding the exercise of the Option. No adjustment will
be made for a dividend  or other right for which the record date is prior to the
date the share certificate is issued, except as provided in the Plan.

      10.   TERMINATION OF EMPLOYMENT.

      (a) TERMINATION OF STATUS AS AN EMPLOYEE.  If any Employee ceases to be in
Continuous Status as an Employee,  other than (i) by reason of retirement,  (ii)
death, or (iii) as a result of a termination by the Company for willful or gross
misconduct,   including,  without  limitation,  breach  of  fiduciary  duty,  as
determined by the Committee  (whose  determination  shall be final,  binding and
conclusive),  any Option held by such Employee shall be exercisable within three
(3) months  after the date he ceases to be in  Continuous  Status as an Employee
(or  such  longer  period  as the  Committee  shall  determine,  in its sole and
absolute  discretion)  to the extent the Employee was entitled to exercise  such
Option as of the date of his  termination  of  employment,  unless the Committee
provides  for a shorter or longer  period.  Notwithstanding  the  foregoing,  in
granting  Incentive Stock Options,  the Committee,  in its sole discretion,  may
elect to limit the period that an Employee may exercise an Option  following his
termination to the periods prescribed by Section 422 of the Code (or any shorter
periods as the Committee shall determine).

      (b)  RETIREMENT  OF OPTIONEE.  If any Employee  ceases to be in Continuous
Status as an Employee by reason of such Employee's  retirement,  any Option held
by such Employee shall be exercisable  within  thirty-six  (36) months after the
date he ceases to be in  Continuous  Status as an Employee to the extent that he
was entitled to exercise  such Option as of the date of his  retirement,  unless
the Committee provides for a shorter or longer period. For purposes of the Plan,
"retirement" means voluntary  termination of services as an Employee at or after
age  sixty-five  (65) other  than as a result of  willful  or gross  misconduct,
unless determined otherwise by the Committee.



                                      -5-
<PAGE>

      (c) TERMINATION FOR MISCONDUCT. If any Employee ceases to be in Continuous
Status as an Employee as a result of a termination by the Company for willful or
gross misconduct,  including, without limitation,  breach of fiduciary duty (the
Committee's   determination   in  this  regard  shall  be  final,   binding  and
conclusive),  any  and  all  Options  held  by  such  Employee  shall  terminate
immediately  and  automatically  at the time of his  termination as an Employee,
unless the Committee  provides for an earlier or later time for the  termination
of such Option(s), and such Option(s) will not be exercisable after such time of
termination, unless otherwise determined by the Committee.

      (d) DEATH OF OPTIONEE.  Subject to the  provisions of the Plan, any Option
held by an Optionee at the time of his death may be  exercised  subsequently  by
the legal  representative  of the Optionee's estate during the remaining term of
the Option,  but only to the extent the Optionee  was entitled to exercise  such
Option as of the date of his death,  unless the Committee  provides for a longer
or shorter  period.  In the event of the death of an  Optionee  during the final
three (3) months of the time  period  specified  in Section  10(a) or 10(b),  as
applicable,  the Option may be  exercised,  at any time within  three (3) months
following  the date of his  death,  by the  Optionee's  estate or by a person or
persons who acquired the right to exercise the Option by bequest or inheritance,
but only to the extent the Optionee  was entitled to exercise  such Option as of
the date of his death,  unless the  Committee  provides  for a longer or shorter
period.

      (e)  EXPIRATION  OF OPTIONS.  None of the events  described  above in this
Article 10 shall extend the period of  exercisability  of the Option  beyond the
expiration  date  thereof.  To the extent that an Optionee  was not  entitled to
exercise  an  Option  on the date he  ceased  to be in  Continuous  Status as an
Employee or the date of the  Optionee's  death,  or if he does not exercise such
Option (which he was entitled to exercise)  within the time period  specified in
this  Article  10,  the  Option  shall  terminate  and  become  null  and  void.
Notwithstanding  the provisions of Section 10(a), 10(b) or 10(d) of the Plan, no
Options shall be exercisable after an Optionee ceases to be in Continuous Status
as an Employee in the event the Optionee  shall have,  during the time period in
which his  Options  are  exercisable,  engaged in  deliberate  action  that,  as
determined by the Committee in its sole discretion (whose determination shall be
final, binding and conclusive),  causes substantial harm to the interests of the
Company  or  constitutes  a breach  of any  obligation  of the  Optionee  to the
Company. In such event, the Optionee shall forfeit all rights to any unexercised
Option as of the date of such deliberate action and all such unexercised Options
shall  terminate  immediately and  automatically  at the time of such deliberate
action.

      (f)  NON-EMPLOYEE  DIRECTORS,  INDEPENDENT  CONTRACTORS  AND  AGENTS.  The
Committee  shall have the authority to determine in its sole  discretion  (whose
determination shall be final, binding and conclusive) the ability of an Optionee
who is not an Employee to exercise an Option following termination of his or her
relationship with the Company and its Parent and Subsidiaries.

      11.  NON-TRANSFERABILITY  OF OPTIONS.  An Option may not be sold, pledged,
assigned, hypothecated,  transferred, or disposed of in any manner other than by
will or by the laws of descent  and  distribution  or  pursuant  to a  qualified
domestic  relations  order as  defined  in the  Code or Title I of the  Employee
Retirement  Income  Security Act of 1974, as amended,  or the rules  thereunder,
and, except with respect to a qualified  domestic  relations order as aforesaid,
may be exercised,  during the lifetime of the Optionee,  only by the Optionee or
his legal representative.




                                      -6-
<PAGE>



      12.   ADJUSTMENTS  UPON  CHANGES  IN  CAPITALIZATION;  CHANGE IN  CONTROL;
            DISSOLUTION.

      (a) Subject to any  required  action by the  shareholders  of the Company,
each of (i) the number of Common Shares covered by each outstanding Option, (ii)
the number of Common  Shares that have been  authorized  for issuance  under the
Plan but as to which no Options have yet been granted or that have been returned
to the Plan upon cancellation, termination or expiration of an Option, (iii) the
exercise price per Share covered by each such outstanding  Option,  and (iv) the
maximum  number of Shares  with  respect to which  Options may be granted to any
Employee  in any  calendar  year,  shall  be  proportionately  adjusted  for any
increase or  decrease in the number of issued  Common  Shares  resulting  from a
stock split or the payment of a stock dividend with respect to the Common Shares
or any other increase or decrease in the number of issued Common Shares effected
without receipt of consideration  by the Company;  provided,  however,  that (A)
each such adjustment with respect to an Incentive Stock Option shall comply with
the rules of Section 424(a) of the Code (or any successor  provision) and (B) in
no event shall any  adjustment  be made that would  render any  Incentive  Stock
Option granted hereunder to be treated other than as an "incentive stock option"
as defined in Section  422 of the Code;  and  provided  further,  however,  that
conversion of any  convertible  securities of the Company shall not be deemed to
have been "effected without receipt of consideration."  Such adjustment shall be
made by the  Committee,  whose  determination  in that  respect  shall be final,
binding and conclusive.  Except as expressly provided herein, no issuance by the
Company of shares of any class,  or  securities  convertible  into shares of any
class,  shall affect,  and no  adjustment  by reason  thereof shall be made with
respect to, the number or exercise price of Common Shares subject to an Option.

      (b) In the event of a  dissolution  or  liquidation  of the  Company,  all
outstanding Options will terminate upon the consummation of such action,  unless
otherwise provided by the Committee.

      (c) The  exercisability of each Option shall be automatically  accelerated
so that each such Option outstanding  shall,  immediately prior to the specified
effective date of any of the following  events,  become fully  exercisable  with
respect  to the  total  number  of  Shares  subject  to such  Option  and may be
exercisable for all or any portion of such Shares, in the event that:

            (i) any person (as defined for  purposes of Section  13(d) and 14(d)
of the  Exchange  Act,  but  excluding  the Company and any of its  wholly-owned
subsidiaries)  acquires  direct or indirect  ownership of fifty percent (50%) or
more of the combined  voting  power of the then  outstanding  securities  of the
Company  as a result of a tender  or  exchange  offer,  open  market  purchases,
privately negotiated purchases or otherwise;

            (ii) any  election has occurred of persons to the Board of Directors
of the Company that causes  two-thirds  of the  Company's  Board of Directors to
consist of persons  other than (A)  persons  who were  members of the  Company's
Board of Directors on January 1, 1997 and (B) persons who were  nominated by the
Company's  Board of Directors for election as members of the Company's  Board of
Directors  at a  time  when  two-thirds  of the  Company's  Board  of  Directors
consisted  of persons who were  members of the  Company's  Board of Directors on
January 1, 1997;  provided,  however,  that any person nominated for election by
the Board of Directors of the Company at least  two-thirds  of whom  constituted
persons  described  in  clauses  (A)  and/or  (B) above or by  persons  who were
themselves  nominated by such Board shall,  for this purpose,  be deemed to have
been nominated by a Board composed of persons described in clause (A) above; or



                                      -7-
<PAGE>

            (iii) the  shareholders  of the Company  approve  (A) any  statutory
consolidation, merger or amalgamation of the Company in which the Company is not
the surviving corporation (other than a merger or amalgamation of the Company in
which  the  holders  of  Common  Shares  immediately  prior  to  the  merger  or
amalgamation have the same proportionate  ownership of the surviving corporation
immediately after the merger or amalgamation),  or (B) any sale, lease, exchange
or other transfer (in one  transaction or a series of related  transactions)  of
all, or substantially all, of the assets of the Company to an entity that is not
a wholly-owned subsidiary of the Company.

      (d) In the event of an acquisition  by the Company of another  corporation
where the Company  assumes under the Plan  outstanding  stock options or similar
obligations of such  corporation,  the number of Shares available under the Plan
shall be  appropriately  increased  to reflect  the number of shares  under such
options or other obligations assumed.

      (e) Adjustments and determinations  under this Article 12 shall be made by
the  Committee,  upon the advice of  counsel,  whose  decisions  shall be final,
binding and conclusive.

      13. TIME FOR GRANTING OPTIONS. The date of grant of an Option shall be the
date on which the Committee makes the determination granting such Option or such
later date as the Committee may specify.  Notice of the  determination  shall be
given to each Employee to whom an Option is so granted within a reasonable  time
after the date of such grant.

      14.  AMENDMENT  AND  TERMINATION  OF THE PLAN AND OPTIONS.  Subject to the
provisions of this Article 14, the Plan may be amended, suspended,  discontinued
or terminated at any time by the Committee without the approval of the Company's
shareholders  in such respects as the  Committee may deem  advisable so that the
Plan  and/or  Options  may  conform  to any  changes  in the law or in any other
respect which the Committee may deem to be in the best interests of the Company,
other than any amendments  required to be approved by shareholders under (i) the
Canada Business  Corporation  Act, (ii) the rules of the securities  exchange or
Nasdaq on which the Common  Shares are listed,  or (iii)  Section  162(m) of the
Code, or any other requirement of applicable law or regulation. No Option may be
granted  during  any  suspension  or  discontinuance  of the Plan or  after  its
termination.  Amendments  to the Plan also  shall be  subject  to any  approvals
required under  applicable laws or regulations or under the applicable  rules of
any stock exchange or Nasdaq on which the Common Shares are listed. In addition,
subject  to the  provisions  of this  Article  14, the  Committee  may waive any
conditions or rights under,  or amend,  suspend,  discontinue or terminate,  any
Option and/or the terms of any corresponding Option agreement; provided, however
that the Committee  may amend any Option  and/or the terms of any  corresponding
Option  agreement  only  to the  extent  that  the  Option  and/or  such  Option
agreement,  as either may be amended,  could have been  granted  pursuant to the
Plan with such  amended  terms.  No amendment of an Option shall be deemed to be
the grant of a new Option for purposes of the Plan.  In addition,  no amendment,
suspension,  discontinuation  or  termination  of the Plan or any Option  shall,
without an Optionee's  consent,  impair any of such Optionee's  rights under any
Option theretofore granted to such Optionee.

      15.   CONDITIONS UPON ISSUANCE OF SHARES.

      (a)  Shares  shall not be issued  pursuant  to the  exercise  of an Option
unless the  exercise of such Option and the issuance and delivery of such Shares
pursuant  thereto shall comply with all relevant  provisions of law,  including,
without limitation,  the Canadian Business  Corporations Act, the Securities Act
(Quebec),  the Securities  Act of 1933, as amended,  the Exchange Act, the rules
and  regulations  promulgated  thereunder,  and the  requirements  of any  stock


                                      -8-
<PAGE>

exchange  upon  which the  Shares  may then be listed  or  Nasdaq,  and shall be
further  subject to the advice of counsel for the Company  with  respect to such
compliance. As a condition to the exercise of an Option, the Company may require
the  person  exercising  such  Option  to  complete  a  questionnaire  in a form
acceptable  to the Company and to make certain  representations  and  warranties
required or desirable (in the opinion of the Company or its counsel), including,
without  limitation,  any representations and warranties required by law, in the
opinion of counsel,  regarding  investment intent. If, in the opinion of counsel
for the Company,  such a representation is required by any of the aforementioned
relevant  provisions  of laws,  certificates  representing  Shares  issued  upon
exercise of the Option shall bear a legend  prohibiting  transfer of such Shares
unless,  in the opinion of such counsel,  such transfer is not inconsistent with
any of the requirements of any applicable  Canadian and United States securities
laws.

      (b) Inability of the Company to obtain  authority from any regulatory body
having  jurisdiction,  which authority is deemed by the Company's  counsel to be
necessary to the lawful issuance and sale of any Shares hereunder, shall relieve
the Company of any  liability in respect of failure to issue or sell such Shares
as to which such requisite authority shall not have been obtained.

      (c)  In  the  event  that  any  Option  is  exercised  by  the  executors,
administrators,  legatees or distributees of the estate of a deceased  Optionee,
the Company shall be under no obligation  to issue stock  thereunder  unless and
until the Company is satisfied that the person or persons  exercising the Option
are the duly appointed legal  representatives of the deceased  Optionee's estate
or the proper legatees or distributees thereof.

      16.  OPTION  AGREEMENTS.  Options  shall be  evidenced  by written  Option
agreements in such form as the Committee shall approve from time to time.

      17. SHAREHOLDER  APPROVAL.  The effectiveness of the Plan shall be subject
to approval by the  shareholders  of the  Company,  in a separate  vote,  within
twelve (12) months after the date the Plan is adopted. Such shareholder approval
shall be obtained, at a duly held shareholders' meeting, by the affirmative vote
of a majority of the votes actually cast, in person or by proxy, at such meeting
on a separate  proposal  to  approve  the Plan.  All  Options  granted  prior to
shareholder  approval are granted  conditional upon shareholder  approval of the
Plan, except to the extent that any Option agreement  expressly provides for the
continuance of the Options granted thereby (as non-plan,  nonqualified  options)
notwithstanding the termination of the Plan.

      18. INDEMNIFICATION OF COMMITTEE MEMBERS. In addition to such other rights
of indemnification as they may have members of the Company's Board of Directors,
the members of the  Committee  shall be, to the extent  permitted by  applicable
law,  indemnified by the Company  against,  and the Company shall  advance,  the
reasonable expenses, including attorneys' fees actually and necessarily incurred
in  connection  with  the  defense  of any  action,  suit or  proceeding,  or in
connection with any appeal therein,  to which they or any of them may be a party
by reason of any action taken or failure to act under or in connection  with the
Plan or any Option granted  thereunder,  and against all amounts paid by them in
settlement  thereof (provided such settlement is approved to the extent required
by and in the manner provided by the Articles of Incorporation and Bylaws of the
Company), or paid by them in satisfaction of a judgment in any such action, suit
or proceeding, except in relation to matters as to which it shall be adjudged in
such action,  suit or proceeding that such Committee  member did not act in good
faith and in a manner he reasonably  believed to be in the best interests of the
Company.  Within sixty (60) days after  institution of any such action,  suit or
proceeding,  a Committee  member shall notify the Company of the  institution of
the suit  and  grant to the  Company  in  writing  the  opportunity,  at its own
expense, to handle and defend the same. Failure to provide such notice and grant


                                      -9-
<PAGE>

shall, at the option of the Company,  relieve the Company of the indemnification
obligations set forth in this Article 18.

      19. OTHER  COMPENSATION  PLANS.  The adoption of the Plan shall not affect
any other share option or incentive  or other  compensation  plans in effect for
the Company or any Subsidiary or Parent, nor shall the Plan preclude the Company
from  establishing  any  other  forms of  incentive  or other  compensation  for
employees and directors of the Company or any Subsidiary or Parent.

      20.  HEADINGS.  Headings of Articles and Sections  hereof are inserted for
convenience and reference; they constitute no part of the Plan.

      21. RESERVATION OF SHARES. The Company,  during the term of the Plan, will
at all  times  reserve  and keep  available  such  number  of Shares as shall be
sufficient to satisfy the requirements of the Plan.

      22.  APPLICATION OF FUNDS.  The proceeds  received by the Company from the
sale of Common  Shares  pursuant to Options  will be used for general  corporate
purposes.

      23.  UNFUNDED PLAN.  The Plan shall be unfunded.  The Company shall not be
required  to  establish  any  special  or  separate  fund or to make  any  other
segregation  of assets to assure the  issuance  of Shares  under the Plan or the
payment of monies  under the Plan and the  issuance of Shares and the payment of
monies to  Optionees  under the Plan shall be  subordinate  to the claims of the
Company's general creditors.

      24. TAXES.  The Company  shall be entitled to withhold (or secure  payment
from the Optionee in lieu of withholding) the amount of any withholding or other
tax  required by law to be withheld or paid by the Company  with  respect to any
Shares  issuable  under  such  Optionee's   Option,   or  upon  a  disqualifying
disposition of Shares  received  pursuant to the exercise of an Incentive  Stock
Option,  and the Company may defer issuance of Shares upon the grant or exercise
of an Option unless  indemnified to its  satisfaction  against any liability for
any such tax. The amount of such  withholding or tax payment shall be determined
by the Company and shall be payable by the  Optionee at such time as the Company
determines.  The Committee  may  prescribe in each Option  agreement one or more
methods  by  which  the  Optionee  will  be  permitted  to  satisfy  his  or her
withholding or tax obligation,  which methods may include,  without  limitation,
(i) the  payment of cash by the  Optionee  to the  Company,  (ii) the payment in
Common Shares already owned by Optionee,  based on the Fair Market Value of such
Common  Shares  on the date  that the  withholding  or tax  obligation  is to be
determined,  to satisfy  such  withholding  or tax  requirements,  and (iii) the
withholding  from the Option,  at the  appropriate  time,  of a number of Shares
sufficient, based upon the Fair Market Value of such Shares on the date that the
withholding or tax obligation is to be determined,  to satisfy such  withholding
or tax requirements.

      25.  INCENTIVE  STOCK  OPTIONS.  In the  case of any  grant  of an  Option
intended to be an Incentive Stock Option,  whenever possible,  each provision in
the Plan and in any related Option  agreement  (other than those relating to the
exercise of Options following termination of employment) shall be interpreted in
such a manner as to  entitle  the  Optionee  to the tax  treatment  afforded  by
Section  422 of the Code and, if any such  provision  of the Plan or such Option
agreement  shall be held not to comply with  requirements  necessary  to entitle
such Option to such tax treatment,  then (a) such  provision  shall be deemed to
have  contained  from the outset such  language as shall be necessary to entitle


                                      -10-
<PAGE>

the Option to the tax treatment  afforded under Section 422 of the Code, and (b)
all other  provisions  of the Plan and the  Option  agreement  relating  to such
Option shall remain in full force and effect.  If any Option agreement  covering
an Option  designated by the Committee to be an Incentive Stock Option shall not
explicitly  include any terms required to entitle such Incentive Stock Option to
the tax treatment afforded by Section 422 of the Code (other than those relating
to the exercise of Options following termination of employment),  all such terms
shall be deemed implicit in the designation of such Option as an Incentive Stock
Option and the Option shall be deemed to have been  granted  subject to all such
terms.

      26. NO RIGHT TO  OPTION;  NO RIGHT TO  EMPLOYMENT.  No  employee  or other
person shall have any claim or right to be granted an Option. The Plan shall not
confer upon any Optionee any right with respect to continuation of employment by
the Company or its  Subsidiaries  or Parent,  nor shall it  interfere in any way
with his  right or the  right of the  Company,  its  Subsidiaries  or  Parent to
terminate his employment at any time.

      27. ACCEPTANCE OF PLAN. By accepting any Option or other benefit under the
Plan,  each  Optionee,  for  himself  and for his  successors,  assigns,  heirs,
beneficiaries  and personal  and legal  representatives,  shall be  conclusively
deemed to have indicated his acceptance and ratification of, and consent to, any
action  taken under the Plan by the Company,  the  Committee  and the  Company's
Board of Directors.

      28. OPTIONS NOT INCLUDABLE FOR BENEFIT  PURPOSES.  Income recognized by an
Optionee  pursuant  to the  provisions  of the Plan shall not be included in the
determination  of benefits under any employee pension benefit plan (as such term
is defined in Section 3(2) of the  Employee  Retirement  Income  Security Act of
1974, as amended,  or the rules  thereunder) or group insurance or other benefit
plans  applicable to the Optionee  that are  maintained by the Company or any of
its  Subsidiaries,  except as may be  provided  under the terms of such plans or
determined by resolution of the Company's Board of Directors.

      29. GOVERNING LAW. The Plan and all determinations  made and actions taken
pursuant  to the Plan shall be  governed  by the laws of the State of  Delaware,
except that the  issuance of Shares by the Company  upon the exercise of Options
shall be governed by the Canada Business Corporations Act.

      30.  NO  STRICT  CONSTRUCTION.  No rule of  strict  construction  shall be
implied  against  the  Company,  the  Committee,  or  any  other  person  in the
interpretation  of any of the terms of the Plan,  any Option  granted  under the
Plan or any rule or procedure established by the Committee.

      31. SEVERABILITY.  Whenever possible, each provision in the Plan and every
Option at any time granted under the Plan shall be interpreted in such manner as
to be effective and valid under applicable law, but if any provision of the Plan
or any Option at any time granted  under the Plan shall be held to be prohibited
by or invalid  under  applicable  law, then (a) such  provision  shall be deemed
amended to accomplish the  objectives of the provision as originally  written to
the fullest extent permitted by law and (b) all other provisions of the Plan and
every other Option at any time granted under the Plan shall remain in full force
and effect.




                                      -11-
<PAGE>
                          NORTH AMERICAN VACCINE, INC.
              PROXY FOR ANNUAL MEETING OF SHAREHOLDERS MAY 20, 1998

      The  undersigned  hereby names,  constitutes and appoints Sharon Mates and
Neil Flanzraich,  or either of them acting in the absence of the other, with the
power of substitution,  the undersigned's  true and lawful attorney and proxy to
attend,  act and vote for and on behalf of the undersigned at the ANNUAL MEETING
OF  SHAREHOLDERS OF NORTH AMERICAN  VACCINE,  INC. (THE "COMPANY") TO BE HELD AT
275 ARMAND-FRAPPIER BOULEVARD,  LAVAL, QUEBEC, CANADA ON WEDNESDAY, MAY 20, 1998
COMMENCING AT 9:00 A.M.  (LOCAL TIME),  and at any adjournment  thereof,  and to
vote  all  the  shares  of  common  stock  held  of  record  in the  name of the
undersigned in the manner  specified on the reverse side, with all of the powers
that the undersigned would possess if the undersigned were personally present.

      THE UNDERSIGNED  RESERVES THE RIGHT TO REVOKE THIS PROXY AT ANY TIME PRIOR
TO ITS  EXERCISE  BY (i) DULY  FILING A WRITTEN  NOTICE OF  REVOCATION  WITH THE
SECRETARY OF THE COMPANY,  (ii) DULY  EXECUTING AND DELIVERING A PROXY BEARING A
LATER DATE TO THE SECRETARY OF THE COMPANY, (iii) VOTING IN PERSON AT THE ANNUAL
MEETING OR (iv) IN ANY OTHER MANNER  PERMITTED BY LAW. FOR ANY WRITTEN NOTICE OF
REVOCATION OR  LATER-DATED  PROXY TO BE  EFFECTIVE,  IT MUST BE DELIVERED TO THE
COMPANY'S  REGISTERED  OFFICE AT ANY TIME UP TO AND  INCLUDING THE LAST BUSINESS
DAY PRECEDING THE DAY OF THE ANNUAL MEETING,  OR ANY ADJOURNMENT  THEREOF, OR TO
THE  CHAIRMAN  OF THE ANNUAL  MEETING ON THE DAY OF THE ANNUAL  MEETING,  OR ANY
ADJOURNMENT THEREOF. THE COMPANY'S REGISTERED OFFICE IS LOCATED AT 1 PLACE VILLE
MARIE, 40TH FLOOR, MONTREAL, QUEBEC H3B 4M4, CANADA.

      THE  UNDERSIGNED  MAY APPOINT A PROXYHOLDER,  OTHER THAN THE  PROXYHOLDERS
IDENTIFIED ABOVE, TO ATTEND AND ACT ON THE UNDERSIGNED'S  BEHALF AT THE MEETING.
TO DO SO,  STRIKE  THE NAME OF THE  PROXYHOLDERS  ABOVE  AND  SPECIFY  ABOVE THE
STRICKEN NAMES THE NAME(S) OF THE PERSON(S) SO APPOINTED.

      THIS PROXY IS BEING  SOLICITED  ON BEHALF OF  MANAGEMENT  OF THE  COMPANY.
UNLESS A CONTRARY  DIRECTION IS INDICATED IN THIS PROXY, THE SHARES  REPRESENTED
BY THIS PROXY WILL BE VOTED FOR: (1) ALL NOMINEES FOR DIRECTORS NAMED BELOW, (2)
APPROVAL OF THE COMPANY'S  1997 SHARE OPTION PLAN AND (3)  APPOINTMENT OF ARTHUR
ANDERSEN LLP AS  INDEPENDENT  PUBLIC  ACCOUNTANTS  OF THE  COMPANY.  IF SPECIFIC
INSTRUCTIONS  ARE  INDICATED,  THIS PROXY WILL BE VOTED IN ACCORDANCE  WITH SUCH
INSTRUCTIONS.  THIS  PROXY  CONFERS  DISCRETIONARY  AUTHORITY  WITH  RESPECT  TO
AMENDMENTS  OR VARIATIONS  TO THE MATTERS  IDENTIFIED IN THE NOTICE  CALLING THE
ANNUAL  MEETING  OR OTHER  MATTERS  THAT MAY  PROPERLY  COME  BEFORE  THE ANNUAL
MEETING,  AND  ACCORDINGLY,  IN THE EVENT THERE ARE ANY SUCH AMENDMENTS OR OTHER
MATTERS  BROUGHT  BEFORE THE ANNUAL MEETING OR ANY  ADJOURNMENT OR  POSTPONEMENT
THEREOF,  THIS  PROXY  WILL BE VOTED IN  ACCORDANCE  WITH  THE  JUDGMENT  OF THE
PROXYHOLDERS.

PLEASE VOTE, DATE AND SIGN THIS PROXY AND RETURN IT AT ONCE,  WHETHER OR NOT YOU
EXPECT TO ATTEND THE ANNUAL MEETING. YOU MAY VOTE IN PERSON IF YOU DO ATTEND THE
ANNUAL  MEETING.  IF THIS PROXY IS NOT DATED IN THE SPACE PROVIDED  BELOW, IT IS
DEEMED TO BEAR THE DATE ON WHICH IT IS MAILED TO SHAREHOLDERS.

                         (TO BE SIGNED ON REVERSE SIDE)


<PAGE>


         Please mark your
 /X/     votes as in this
         example.

<TABLE>
<CAPTION>

                     FOR      WITHHOLD     Nominees:                                                  FOR      AGAINST      ABSTAIN
<S>                  <C>      <C>          <C>                        <C>                             <C>      <C>          <C>

1. Election of       /  /       /  /       Neil W. Flanzraich         2. Approval of the Company's
    Directors.                             Francesco Bellini             1997 Share Option Plan.      / /         / /          / /  
                                           Phillip Frost
FOR, except vote withheld from the         Alain Cousineau            3. Appointment of Independent   / /         / /          / /
following nominee(s):                      Jonathan Deitcher             Accountants.
                                           Denis Dionne
                                           Lyle Kasprick              4. Upon such other  matters as may properly
- -----------------------------------        Francois Legault              come before,  or incident to the conduct
                                           Sharon Mates                  of,  the  meeting  or  any   adjournment
                                           Richard C. Pfenniger, Jr.     thereof   in   such    manner   as   the
                                           Gervais Dionne                proxyholders determine to be in the best
                                                                         interests of the Company.  Management is
                                                                         not presently  aware of any such matters
                                                                         to  be  presented   for  action  at  the
                                                                         meeting.
</TABLE>


SIGNATURE(S)                                          DATE
            --------------------------------------         --------------------

NOTE:      PLEASE SIGN EXACTLY AS NAME APPEARS HEREON.  JOINT OWNERS SHOULD EACH
           SIGN. WHEN SIGNING AS ATTORNEY, EXECUTOR,  ADMINISTRATOR,  TRUSTEE OR
           GUARDIAN, PLEASE GIVE FULL TITLE AS SUCH.




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