NORTH AMERICAN VACCINE INC
DEF 14A, 1999-02-01
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  SCHEDULE 14A

                            SCHEDULE 14A INFORMATION
           Proxy Statement Pursuant to Section 14(a) of the Securities
                              Exchange Act of 1934
                               (Amendment No. __)

Filed by Registrant [X]

Filed by a Party other than the Registrant [ ]

Check the appropriate box:

      [ ] Preliminary Proxy Statement
      [ ] Confidential, for Use of the Commission Only (as permitted by Rule
          14a-6(e)(2)) 
      [X] Definitive Proxy Statement 
      [ ] Definitive Additional Materials 
      [ ] Soliciting Material Pursuant to Section 240.14a-11(c) or Section 
          240.14a-12


                          North American Vaccine, Inc.
               --------------------------------------------------
                (Name of Registrant as Specified In Its Charter)

                          
               --------------------------------------------------
      (Name of Person(s) Filing Proxy Statement, if other than Registrant)

Payment of Filing Fee (Check the appropriate box):

      [X]   No fee required.
      [ ]   Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and
            0-11:

            1)    Title of each class of securities to which transaction
                  applies:______________________________________________

            2)    Aggregate number of securities to which transaction
                  applies:______________________________________________

            3)    Per unit price or other underlying value of transaction
                  computed pursuant to Exchange Act Rule 0-11 (set forth the
                  amount on which the filing fee is calculated and state how it
                  was determined):______________________________________

            4)    Proposed maximum aggregate value of
                  transaction:__________________________________________

            5)    Total fee paid:_______________________________________

      [ ]   Fee paid previously with preliminary materials.

      [ ]   Check box if any part of the fee is offset as provided by
            Exchange Act Rule 0-11(a)(2) and identify the filing for which the
            offsetting fee was paid previously. Identify the previous filing by
            registration statement number, or the Form or Schedule and the date
            of its filing.



<PAGE>


      1)    Amount Previously Paid:_______________________________________

      2)    Form, Schedule or Registration Statement No.:_________________

      3)    Filing Party:_________________________________________________    

      4)    Date Filed:___________________________________________________    

<PAGE>


                             NORTH AMERICAN VACCINE, INC.
                                10150 OLD COLUMBIA ROAD
                           COLUMBIA, MARYLAND 21046 U.S.A.
                               -------------------------

                       NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
                             TO BE HELD FEBRUARY 23, 1999
                               -------------------------

      NOTICE IS HEREBY  GIVEN that the 1999 Annual  Meeting of  Shareholders  of
North American Vaccine,  Inc., a Canadian  corporation (the "Company"),  will be
held  at 275  Armand-Frappier  Boulevard,  Laval,  Quebec,  Canada  on  Tuesday,
February 23, 1999 commencing at 9:00 a.m., local time.

      THE PURPOSES of the Annual Meeting will be:

      1.    To elect the Board of Directors for the ensuing year;
      2.    To approve  the  Company's  1999  Non-Employee  Director  and Senior
            Executive Stock Option Plan;
      3.    To appoint Arthur Andersen LLP as independent  public accountants of
            the Company; and
      4.    To consider  and act upon any other  matter that may  properly  come
            before,   or  incident  to  the  conduct  of,  the  meeting  or  any
            adjournment thereof.

      All shareholders are cordially  invited to attend the Annual Meeting.  The
record date for determining  those  shareholders  entitled to vote at the Annual
Meeting is January 15, 1999. A review of the Company's  operations  for the year
ended  December 31, 1998 will be presented.  The Company's 1998 Annual Report to
Shareholders  (including audited financial statements) is enclosed.  The meeting
will be subject to adjournment as the shareholders present in person or by proxy
may determine.

                                          By Order of the Board of Directors,


                                          Daniel J. Abdun-Nabi
                                          SECRETARY
February 1, 1999

IMPORTANT--WHETHER  OR NOT YOU PLAN TO ATTEND THE ANNUAL MEETING IN PERSON,  YOU
CAN HELP IN THE PREPARATION FOR THE ANNUAL MEETING BY FILLING IN AND SIGNING THE
ENCLOSED PROXY CARD AND PROMPTLY RETURNING IT IN THE ENCLOSED  ENVELOPE.  IF YOU
ARE UNABLE TO ATTEND,  YOUR SHARES  WILL BE VOTED AS DIRECTED BY YOUR PROXY.  IF
YOU DO ATTEND THE MEETING, YOU MAY VOTE YOUR SHARES EVEN THOUGH YOU HAVE SENT IN
YOUR PROXY CARD.


<PAGE>

                             NORTH AMERICAN VACCINE, INC.
                                10150 OLD COLUMBIA ROAD
                           COLUMBIA, MARYLAND  21046  U.S.A.
                                  -------------------

                                    PROXY STATEMENT
                                  -------------------

      THIS PROXY STATEMENT IS FURNISHED IN CONNECTION  WITH THE  SOLICITATION BY
MANAGEMENT OF NORTH AMERICAN  VACCINE,  INC. (THE  "COMPANY") OF PROXIES FOR THE
1999 ANNUAL MEETING OF SHAREHOLDERS  OF THE COMPANY AND ANY ADJOURNMENT  THEREOF
(THE  "MEETING") TO BE HELD AT 275  ARMAND-FRAPPIER  BOULEVARD,  LAVAL,  QUEBEC,
CANADA COMMENCING AT 9:00 A.M., LOCAL TIME, ON TUESDAY,  FEBRUARY 23, 1999. This
Proxy  Statement,  together with the  accompanying  proxy and the Company's 1998
Annual Report to Shareholders (including audited financial statements), is first
being sent or given to the Company's  shareholders on approximately  February 1,
1999.

      The  cost  of  soliciting  proxies  will  be  borne  by the  Company.  The
solicitation  of proxies by mail may be  followed by  personal  solicitation  of
certain  shareholders  by officers or regular  employees of the  Company.  Proxy
materials  will  also be  distributed  through  brokers,  custodians  and  other
nominees or fiduciaries to beneficial  owners of the Company's Common Stock. The
Company  expects to  reimburse  such  persons for their  charges and expenses in
connection with this distribution.

      Each proxy that is properly  executed  and  returned  will be voted for or
against  or  withheld  from  voting  on any  ballot  that may be  called  for in
accordance with the instructions contained in that proxy. IF NO INSTRUCTIONS ARE
GIVEN,  SUCH PROXY WILL BE VOTED FOR THE ELECTION OF THE COMPANY'S  NOMINEES FOR
DIRECTOR,  THE APPROVAL OF THE COMPANY'S 1999  NON-EMPLOYEE  DIRECTOR AND SENIOR
EXECUTIVE  SHARE OPTION PLAN (THE "1999 SESOP"),  AND THE  APPOINTMENT OF ARTHUR
ANDERSEN LLP AS THE COMPANY'S  INDEPENDENT PUBLIC ACCOUNTANTS.  THE ACCOMPANYING
PROXY CONFERS  DISCRETIONARY  AUTHORITY WITH RESPECT TO AMENDMENTS OR VARIATIONS
TO THE MATTERS  IDENTIFIED  IN THE NOTICE  CALLING THE MEETING OR OTHER  MATTERS
THAT MAY PROPERLY COME BEFORE THE MEETING.  IF THERE ARE ANY SUCH  AMENDMENTS OR
VARIATIONS OR OTHER MATTERS  BROUGHT  BEFORE THE MEETING OR ANY  ADJOURNMENT  OR
POSTPONEMENT  THEREOF, ALL PROXIES WILL BE VOTED IN ACCORDANCE WITH THE JUDGMENT
OF THE PERSONS NAMED AS PROXIES.

      A  shareholder  may  revoke  his or her  proxy  at any  time  prior to its
exercise by (1) duly filing a written notice of revocation with the Secretary of
the Company,  (2) duly  executing and delivering a proxy bearing a later date to
the Secretary of the Company, (3) voting in person at the Meeting, or (4) in any
other  manner  permitted  by law.  For  any  written  notice  of  revocation  or
later-dated  proxy  to be  effective,  it must  be  delivered  to the  Company's
registered  office  at any  time  up to and  including  the  last  business  day
preceding the day of the Meeting, or any adjournment thereof, or to the chairman
of the  Meeting  on the day of the  Meeting,  or any  adjournment  thereof.  The
Company's  registered  office is located at 1 Place  Ville  Marie,  40th  Floor,
Montreal, Quebec H3B 4M4, Canada.

      If a quorum is present,  the  affirmative  vote of a majority of the votes
actually cast at the Meeting,  in person or by proxy, is necessary to elect each
of the nominees for  director,  to approve the 1999 SESOP and to appoint  Arthur
Andersen  LLP  as  the  Company's  independent  public  accountants for the year
ending  December  31, 1999.   For  purposes  of  tallying  the  number  of votes












<PAGE>

actually cast at the Meeting for the election of directors, approval of the 1999
SESOP  and  appointment  of  independent  public  accountants,  any vote  "for,"
"against"  or to  "withhold"  from voting shall be tallied as a vote cast at the
Meeting.

      "Broker  non-votes"  represent  shares  held by brokers or  nominees as to
which (i) the broker or nominee does not have  discretionary  voting power under
the applicable  exchange rules and (ii) instructions have not been received from
the beneficial owners or the persons entitled to vote such shares. The Company's
understanding  is that brokers will have  discretionary  voting authority on all
three proposals before the meeting. Abstentions and broker non-votes will not be
counted  as votes  actually  cast at the  Meeting  on any  matter to which  they
relate.  Finally,  abstentions will, and "broker non-votes" will not, be treated
as shares that are present and entitled to vote for purposes of determining  the
presence of a quorum.

      In accordance with the Company's By-laws,  the stock transfer records were
compiled at the close of business  on January 15,  1999,  the record date set by
the Board of Directors for determining the  shareholders  entitled to notice of,
and to vote at, the Meeting and any  adjournment  thereof.  On that date,  there
were 32,216,106 outstanding shares of the Company's Common Stock. The holders of
the  outstanding  shares at the close of  business  on January  15, 1999 will be
entitled to one vote for each share held by them as of such date.

                                 ELECTION OF DIRECTORS
                                   (PROPOSAL  NO. 1)

      Eleven (11)  directors,  comprising the entire  membership of the Board of
Directors  of the  Company,  are to be  elected  at the  Meeting.  The  Board of
Directors has  nominated  the persons  listed below for election as directors of
the Company.  If a quorum is present, an affirmative vote of a majority of votes
actually cast at the Meeting is required to elect each director.

<TABLE>
<CAPTION>

                      Name                    Age(1)         Position
                      ----                    ---            --------
               <S>                            <C>            <C>

               Neil W. Flanzraich.....    55       Director; Chairman
               Francesco Bellini, Ph.D.   51       Director; Vice Chairman
               Phillip Frost, M.D. ...    62       Director; Vice Chairman
               Alain Cousineau .......    56       Director
               Jonathan Deitcher .....    52       Director
               Denis Dionne ..........    49       Director
               Gervais Dionne, Ph.D. .    52       Director
               Lyle Kasprick .........    66       Director
               Francois Legault.......    42       Director
               Richard C. Pfenniger, Jr.  43       Director
               Randal D. Chase, Ph.D..    49       Nominee for Director; President and Chief
                                                   Executive Officer
               --------------------
               (1)    As of January 1, 1999.
</TABLE>

      The  Company's  directors  are  elected  at  each  annual  meeting  of the
Company's  shareholders  and serve until the next annual meeting of shareholders
or until their  respective  successors are duly elected and qualified,  or their
prior resignation or removal. There are no family relationships among any of the


                                      -2-
<PAGE>

executive  officers  or  directors  of  the  Company.   Under  the  terms  of  a
Shareholders'  Agreement,  the Company's  principal  shareholders have agreed to
vote  together  for the  election  of  directors.  See  "Certain  Transactions."
Background  information regarding each of the Company's nominees for director is
set forth below.

      NEIL W.  FLANZRAICH:  Director  of the  Company  since  October  1989  and
Chairman  since January 1995;  Vice Chairman and President  since May 1998 and a
director  since  1997 of IVAX  Corporation  ("IVAX")  (pharmaceutical  company);
shareholder with law firm of Heller Ehrman White & McAuliffe and Chairman of the
Life Sciences Group of that firm from  September 1995 through May 1998;  General
Counsel,   Senior  Vice  President  and  Secretary  of  Syntex  (U.S.A.),   Inc.
(pharmaceutical  company), a subsidiary of Roche Holding Ltd., from January 1995
to August 1995;  General Counsel from January 1992 to December 1994,  Co-General
Counsel from August 1987 through  January 1992,  and Senior Vice  President from
June 1981 to  December  1994 of Syntex  Corporation,  a  pharmaceutical  company
acquired  by  Roche  Holding  Ltd.  at the  end of  1994;  Director  of  Whitman
Educational   Group,   Inc.   (operator  of  degree  and   non-degree   granting
post-secondary  schools)  since  1997;  Director  of  LXR  Biotechnology,   Inc.
(biotechnology  company)  since 1997;  and Director of  Continucare  Corporation
(health-care management) since January 1998.

      FRANCESCO BELLINI,  PH.D.:  Director of the Company since October 1989 and
Vice Chairman since June 1991;  President from September 1986 to May 1998, Chief
Executive  Officer  since  October 1986 and  Director  since  September  1986 of
BioChem Pharma Inc. ("BioChem") (pharmaceutical company).

      PHILLIP FROST,  M.D.:  Director of the Company since October 1989 and Vice
Chairman since December 1990;  Chairman of the Board and Chief Executive Officer
of IVAX since 1987 and  President  from July 1991 to January  1995;  Chairman of
Whitman  Education  Group,  Inc.  since  1992;   Director  of  Northrop  Grumman
Corporation  (aerospace  company)  since 1996;  Vice  Chairman  and  Director of
Continucare  Corporation  since 1996; a trustee of the University of Miami since
1983;  and a member of the Board of  Governors of the  American  Stock  Exchange
since 1992.

      ALAIN COUSINEAU:  Director of the Company since October 1989;  Chairman of
the Board of Groupe SECOR Inc.  (management  consultants in corporate  strategic
planning)  since  February 1993 and President  from  September  1985 to February
1993;  Partner of Groupe SECOR Inc.  since July 1983;  Director of Bioniche Inc.
(biopharmaceutical  company)  since  September  1996,  which is a public company
trading on the Toronto and Montreal Stock Exchanges.

      JONATHAN DEITCHER:  Director of the Company since February 1990;  Director
and Vice President of RBC Dominion  Securities  (securities  investment  dealer)
since  May  1984;  and  Director  of  Renaissance   Energy  Ltd.  (oil  and  gas
exploration)  since  1982 and  Vincor  International  Inc.  (wine  producer  and
retailer) since November 1993, both of which are public companies trading on the
Toronto Stock Exchange.

      DENIS DIONNE:  Director of the Company  since  October 1989;  President of
Societe financiere  d'innovation inc. ("Sofinov"),  a high technology investment
fund that is a subsidiary  of La Caisse de depot et  placement du Quebec,  since
April 1996;  and Senior  Vice  President,  Economic  Development  and  Strategic
Investments  from 1995 to March 1996,  and Senior Vice  President,  Security and
Investment  from 1988 to March 1996, of Fonds de Solidarite des  Travailleurs du
Quebec, an investment fund.



                                      -3-
<PAGE>

      GERVAIS DIONNE,  PH.D.:  Director of the Company since May 1998; Executive
Vice  President,  Research  and  Development  of BioChem  since  November  1994;
President   and  Chief   Executive   Officer   of  BioChem   Therapeutics   Inc.
(pharmaceutical  company) from February 1993 to November 1994;  Vice  President,
Research  and  Development  of BioChem  from  September  1986 to November  1994;
Director of BioChem  since 1991;  Director of BioChem  Therapeutics  Inc.  since
1993;  Director of GeneChem  Technologies  (investment fund) since May 1997; and
Director of Briana Bio-Tech Inc. since December 1997, a health care company that
is trading on the Vancouver Stock Exchange.

      LYLE  KASPRICK:  Director of the Company  since  October 1989 and Chairman
from June 1991 to January 1995;  private  investor since March 1988;  and, since
June 1993, a member of the Board of Directors  and the  Investment  Committee of
the University of North Dakota Foundation.

      FRANCOIS LEGAULT:  Director of the Company since June 1996; Executive Vice
President, Corporate Development and Investments of BioChem since February 1997;
Senior Vice President,  Finance,  Administration and Treasurer of BioChem,  from
February 1993 to February  1997;  and Vice  President,  Finance and Treasurer of
BioChem from 1987 to February 1993.

      RICHARD C.  PFENNIGER,  JR.:  Director  of the Company  since 1992;  Chief
Executive Officer and Vice Chairman of Whitman Education Group, Inc. since March
1997 and Director since 1992;  Chief Operating  Officer of IVAX from May 1994 to
March 1997;  and Senior Vice  President -- Legal Affairs and General  Counsel of
IVAX from 1989 to May 1994 and Secretary from 1990 to April 1994.

      RANDAL D.  CHASE,  PH.D.:  President  and Chief  Executive  Officer of the
Company  since October 1998;  President and Chief  Executive  Officer of Pasteur
Merieux-Connaught (Canada) (pharmaceutical company) from January 1996 to October
1998  and also  served  as a  member  of the  Executive  Committee  for  Pasteur
Merieux-Connaught (Worldwide), as Chairman of Pasteur Merieux-Connaught (Mexico)
and a member of the Board of Directors of Rhone-Poulenc Canada (a pharmaceutical
company);  and from July 1993 to January  1996,  Dr. Chase was with Quadra Logic
Technologies (a  biotechnology  company)  holding various  positions  including:
Director,  President and Chief Executive  Officer,  and Vice President and Chief
Operating Officer.

      The Board of Directors has established the following committees. The Board
of Directors has not established a standing nominating committee.

      EXECUTIVE   COMMITTEE  -  The  Executive   Committee  is  responsible  for
exercising the authority of the Board of Directors between meetings of the Board
of Directors consistent with the limitations imposed by law. The current members
of this  committee are Neil  Flanzraich,  Francesco  Bellini,  Phillip Frost and
Gervais Dionne.

      AUDIT  COMMITTEE - The Audit Committee is responsible for meeting with the
independent public  accountants and  representatives of management to review the
scope and results of audits, the  appropriateness of accounting  principles used
in financial  reporting,  and the adequacy of financial and operating  controls.
The current members of the Audit Committee are: Lyle Kasprick,  Francois Legault
and Richard Pfenniger.



                                      -4-
<PAGE>

      COMPENSATION  COMMITTEE - The  Compensation  Committee is responsible  for
establishing  executive  compensation  programs,   granting  options  under  the
Company's stock option plans and  interpreting and  administering  the Company's
option plans.  The current  members of the  Compensation  Committee  are:  Alain
Cousineau, Jonathan Deitcher and Denis Dionne.

      During 1998, the Board of Directors of the Company held ten meetings,  the
Executive Committee held three meetings, the Audit Committee held four meetings,
and the Compensation  Committee held seven meetings. All members of the Board of
Directors  attended at least 75% of their Board and committee  meetings combined
during the last fiscal year.

      Additional  nominations  for  director  may be  made  from  the  floor  by
shareholders  at the  Meeting.  In case  any of  these  nominees  should  become
unavailable  for such  election  for any  reason  presently  unknown,  the proxy
holders will have discretionary authority under the proxy to vote for a suitable
substitute nominee.

      COMPENSATION OF DIRECTORS

      Employee directors do not receive  additional  compensation for serving on
the Board of Directors. Non-employee directors received no cash compensation for
their  service  as  directors,  except as  described  below.  Directors  receive
reimbursement  for the expenses that they incur in performing  their services as
directors.

      Non-employee  directors have automatically received annual grants of stock
options  on  January 1 of each year  under the 1995  Non-Employee  Director  and
Senior Executive Stock Option Plan (the "1995 SESOP").  Accordingly,  on January
1, 1998, each non-employee  director  received an option to acquire:  (i) 20,000
shares of the  Company's  Common Stock where the  non-employee  director was the
Chairman of the Board or Vice  Chairman of the Board;  (ii) 5,000  shares of the
Company's  Common Stock for all other  non-employee  directors;  and (iii) 5,000
shares of Company's Common Stock for each committee of the Board of Directors on
which  non-employee  directors (other than the Chairman and Vice Chairman of the
Board) serve.  These options were all granted to such non-employee  directors at
an exercise price of $24.9375 per share,  the fair market value of the Company's
Common Stock on January 1, 1998,  the date of grant.  These options will vest in
three equal annual installments commencing on the January 1st following the date
of the grant.  No current  executive  officer  has  received,  or is entitled to
receive,  options under the 1995 SESOP. With the automatic grant to non-employee
directors  on  January  1,  1999,  there is an  insufficient  number  of  shares
available under the 1995 SESOP to permit any further automatic grants of options
as described above. In order to continue the policy of compensating non-employee
directors through the automatic grant of stock options,  it is intended that the
1995 SESOP will be succeeded by the 1999 SESOP, subject to shareholder approval.
See Proposal No. 2 - "Approval of the Company's 1999  Non-Employee  Director and
Senior Executive Stock Option Plan."

      Neil Flanzraich,  the Chairman of the Board,  received a total of $100,000
for the 1998  calendar  year for his  duties  performed  in that  capacity.  The
Company  maintains  on behalf of the  directors  and  officers  of the Company a
directors' and officers'  liability insurance policy. For the policy year ending
February 28,  1999,  the premium paid by the Company for a policy with a covered
limit of $30 million was  approximately  $333,134,  with a  deductible  of up to
$200,000  per  claim.  No  allocation  of  premium  was made in  respect  of the
directors as a group or the officers as a group.




                                      -5-
<PAGE>


                          IDENTIFICATION OF SENIOR MANAGEMENT

      The following  table  identifies the senior  management of the Company and
the positions  that they hold.  Officers of the Company are elected by the Board
of Directors at the annual meeting  thereof to hold office until  successors are
elected and qualified, or their prior resignation or removal.

<TABLE>
<CAPTION>
             Name                       Age(1)              Position(s)
             ----                       ------              -----------
        <S>                               <C>    <C>

        Randal D. Chase, Ph.D. (2)(3).    49     President and Chief Executive Officer
        Arthur Y. Elliott, Ph.D. (3)..    62     Senior  Vice  President -- Operations  and  Chief
                                                         Operating Officer
        Daniel J. Abdun-Nabi (3)......    44     Senior Vice President -- Legal Affairs and General
                                                         Counsel; Secretary
        Wayne Morges, Ph.D. (3).......    52     Vice President -- Quality/Regulatory Affairs
        Stephen N. Keith, M.D., M.S.P.H.  46     Vice President -- Marketing and Sales
        Edward Arcuri, Ph.D. .........    48     Vice President -- Manufacturing Operations
        Joan D.S. Fusco, Ph.D. .......    43     Vice President -- Business Development
        Lawrence J. Hineline (3)......    42     Vice President -- Finance

</TABLE>

- ------------------------
      (1)   As of January 1, 1999.
      (2)   See  background  description  under heading  "Election of Directors"
            above.
      (3)   These persons are "executive officers" for purposes of the rules and
            regulations of the Securities and Exchange Commission.

      Background  information  regarding each of the Company's senior management
is set forth below.

      ARTHUR Y. ELLIOTT,  PH.D.:  Senior Vice  President -- Operations and Chief
Operating  Officer of the  Company  since March 1994;  Acting  President  of the
Company from September to October 1998;  and, from 1978 to 1994, Dr. Elliott was
with Merck & Co.  (pharmaceutical  company) holding various positions including:
Executive Director, Biological Operations;  Executive Director, Quality Control;
Senior Director,  Biologics;  Director,  Biological Manufacturing;  and Manager,
Viral Vaccines and Veterinary Services.

      DANIEL J.  ABDUN-NABI:  Senior Vice President -- Legal Affairs and General
Counsel of the Company since  February  1990;  and Secretary of the Company from
June 1991.

      WAYNE MORGES, PH.D.: Vice President --  Quality/Regulatory  Affairs of the
Company since January 1995;  Vice President --  Manufacturing  Operations of the
Company from June 1994 to January  1995;  and from 1981 to 1994,  Dr. Morges was
with Merck & Co.  holding  various  positions  including:  Senior  Director  and
Responsible  Head,  Biological  Quality Control;  Director,  Biological  Quality
Control;  Manager,  Hepatitis  Vaccines and Recombinant  Products;  and Manager,
Biological Quality Control Technical Services.



                                      -6-
<PAGE>

      STEPHEN N. KEITH, M.D., M.S.P.H.: Vice President -- Marketing and Sales of
the Company since August 1995; from 1990 to 1995, Dr. Keith was with Merck & Co.
holding various positions including:  Senior Director,  Merck-Medco Managed Care
Division;  Senior  Customer  Manager,  U.S.  Human Health  Division;  and Senior
Director, Corporate Public Affairs.

      EDWARD ARCURI,  PH.D.:  Vice President -- Manufacturing  Operations of the
Company  since  January  1995;  and from March  1991 to  December  1994,  Senior
Director, Biological Manufacturing for Merck & Co.

      JOAN D.S.  FUSCO,  PH.D.:  Vice  President -- Business  Development of the
Company since January 1997; Director of Business Development of the Company from
1995 to January 1997;  and Manager of Business  Development  of the Company from
1993 to 1994.

      LAWRENCE J.  HINELINE:  Vice  President -- Finance  of the  Company  since
November 1993.













                                      -7-
<PAGE>


                       SECURITY OWNERSHIP OF CERTAIN BENEFICIAL
                                 OWNERS AND MANAGEMENT

      The following table sets forth certain information provided to the Company
or contained in filings with the Securities and Exchange  Commission (the "SEC")
regarding the beneficial ownership of shares of the Company's Common Stock as of
December  31,  1998 by (i)  each  person  who is  known  by the  Company  to own
beneficially,  or  exercise  control  or  direction  over,  more  than 5% of the
outstanding  shares of the Company's Common Stock, (ii) all current directors of
the Company,  (iii) all nominees for director,  (iv) each of the Named  Officers
(as  defined  below  in the  section  entitled  "Executive  Compensation-Summary
Compensation Table") and (v) all current directors and executive officers of the
Company as a group. Unless otherwise indicated,  each person has sole voting and
investment  power with respect to the shares  specified  opposite  such person's
name.

<TABLE>
<CAPTION>

     Name of Beneficial Owner                      Number of Shares                  Percent of Class
     ------------------------                      ----------------                  ----------------
     <S>                                            <C>                                  <C>

     BioChem Pharma Inc.......................      14,371,726 (1)                       40.7%
       275 Armand-Frappier Blvd.
       Laval, Quebec H7V 4A7
     Frost-Nevada, Limited Partnership........       4,265,482 (2)                       12.3%
       c/o Phillip Frost, M.D.
       IVAX Corporation
       4400 Biscayne Blvd.
       Miami, Florida 33137
     Phillip Frost, M.D. (3)..................       6,322,898 (2)(4)                    18.2%
       c/o IVAX Corporation
       4400 Biscayne Blvd.
       Miami, Florida 33137
     Delphi Asset Management..................       2,489,225 (5)                        7.8%
       485 Madison Avenue
       New York, New York  10022
     Denver Investment Advisors LLC...........       1,768,900 (6)                        5.5%
       1225 17th Street, 26th Floor
       Denver, Colorado  80202
     Neil W. Flanzraich (3)...................         261,560 (4)                        *
     Francesco Bellini, Ph.D. (3).............          95,198 (4)(7)                     *
     Alain Cousineau (3)......................          39,999 (4)                        *
     Jonathan Deitcher (3)....................          74,999 (4)                        *
     Denis Dionne (3).........................          29,999 (4)(8)                     *
     Gervais Dionne, Ph.D. (3)................             --  (7)                        *
     Lyle Kasprick (3)........................         456,269 (4)                        1.4%



                                      -8-
<PAGE>


     Name of Beneficial Owner                      Number of Shares               Percent of Class
     ------------------------                      ----------------               ----------------

     Francois Legault (3).....................         9,999 (4)(7)                     *
     Sharon Mates, Ph.D. (3)..................       268,837 (4)(11)(12)                *
     Richard C. Pfenniger, Jr. (3)............        74,685 (4)(9)                     *
     Randal D. Chase, Ph.D. (10)..............            --                            *
     Arthur Y. Elliott, Ph.D. (10)............       189,117 (4)(11)                    *
     Daniel J. Abdun-Nabi (10)................       255,850 (4)(11)(13)                *
     Wayne Morges, Ph.D. (10).................        71,701 (4)(11)                    *
     Edward Arcuri, Ph.D. (10)................        83,333 (4)(11)                    *
     All directors and executive officers as a group
       (17 persons)...........................     8,251,196 (2)(4)(8)(9)(11)(12)     23.1%
</TABLE>
    ------------------- 
    * Indicates less than one percent.

     (1)  As reported in  BioChem's  Amendment  No. 4 to its  Schedule 13D dated
          November 12, 1998, the amount shown includes:  1,000,000 shares of the
          Company's  Series  A  Preferred  Stock,  which  are  convertible  into
          2,000,000 shares of the Company's Common Stock, 57,812 shares that may
          be  purchased  upon the  exercise  of stock  options,  and  $9,000,000
          aggregate  principal amount of 4.5% Convertible  Secured Notes,  which
          are convertible  into 1,053,790  shares of the Company's Common Stock.
          See "Certain Transactions."

     (2)  As reported in  Amendment  No. 2 to Schedule  13D dated  November  12,
          1998,  1,767,859  of these  shares are held by  Frost-Nevada,  Limited
          Partnership  ("Frost-Nevada"),  which has sole voting and  dispositive
          power with respect to such shares.  Also includes  1,000,000 shares of
          the Company's  Series A Preferred  Stock,  which are convertible  into
          2,000,000 shares of the Company's  Common Stock,  held by Frost-Nevada
          and $4,250,000  aggregate principal amount of 4.5% Convertible Secured
          Notes,  which are  convertible  into 497,623  shares of the  Company's
          Common Stock, held by Frost-Nevada.  See "Certain  Transactions."  Dr.
          Frost is the sole shareholder of Frost-Nevada Corporation, the general
          partner  of   Frost-Nevada,   and  is  the  sole  limited  partner  of
          Frost-Nevada.  Consequently,  Dr.  Frost  may  be  deemed  to  be  the
          beneficial owner of all such shares held by Frost-Nevada.

     (3)  A director of the Company.

     (4)  Includes,  where  applicable,  shares that may be  purchased  upon the
          exercise of stock options presently  exercisable or exercisable within
          60 days of December 31, 1998 as follows: 59,998 shares with respect to
          Drs. Frost and Bellini and Mr. Flanzraich;  29,999 shares with respect
          to each of Messrs.  Cousineau,  Deitcher,  Denis Dionne and Pfenniger;
          39,999 shares with respect to Mr. Kasprick;  9,999 shares with respect
          to Mr.  Legault;  76,666  shares with  respect to Dr.  Mates;  187,500
          shares with respect to Dr. Elliott; 212,500 shares with respect to Mr.
          Abdun-Nabi;  70,252 shares with respect to Dr.  Morges;  83,333 shares
          with  respect to Dr.  Arcuri;  and 15,000  shares with  respect to one
          unnamed executive officer.



                                      -9-
<PAGE>

     (5)  Reflects aggregate  beneficial ownership of the Company's Common Stock
          held  by  Delphi  Asset  Management  ("Delphi")  in  its  capacity  as
          investment  advisor,  according to its Schedule 13G dated February 17,
          1998.  Delphi  reports  that it has sole voting  power over  1,565,800
          shares of the Company's Common Stock and sole  dispositive  power over
          2,489,225 shares of the Company's Common Stock.

     (6)  Reflects aggregate  beneficial ownership of the Company's Common Stock
          held by Denver  Investment  Advisors  LLC  ("DIA") in its  capacity as
          investment  advisor,  according to its Schedule 13G dated February 11,
          1998. DIA reports that it has sole voting power over 1,158,600  shares
          of  the  Company's  Common  Stock  and  sole  dispositive  power  over
          1,768,900 shares of the Company's Common Stock.

     (7)  Although a director  and/or officer of BioChem,  the named  individual
          disclaims   beneficial   ownership  of  the  Company's   Common  Stock
          beneficially owned by BioChem.

     (8)  20,000  stock  options  are subject to a prior  agreement  between Mr.
          Denis Dionne and his former employer, whereby Mr. Dionne must exercise
          these options at his former employer's direction and then transfer the
          underlying shares of the Company's Common Stock to his former employer
          at cost (exercise  price).  Although an officer of Sofinov,  Mr. Denis
          Dionne disclaims  beneficial  ownership of the shares of the Company's
          Common Stock beneficially  owned by Sofinov.  Sofinov holds $6,250,000
          aggregate  principal amount of 4.5% Convertible  Secured Notes,  which
          are convertible into 731,798 shares of the Company's Common Stock.

     (9)  Includes 19,686 shares held jointly by Mr. Pfenniger and his wife.

     (10) Chief  executive  officer or one of the four most  highly  compensated
          executive officers of the Company.

     (11) Includes,  where applicable,  approximately 2,771, 1,617, 2,778, 1,449
          and 1,752 shares issued under the Company's 401(k) Plan and Trust as a
          matching contribution by the Company to the retirement accounts of Dr.
          Mates,  Dr.  Elliott,  Mr.  Abdun-Nabi,  Dr.  Morges  and one  unnamed
          executive officer, respectively.

     (12) Reflects aggregate  beneficial ownership of the Company's Common Stock
          held by Dr. Mates as reported in her most recent Form 4 (Statement  of
          Changes in  Beneficial  Ownership)  dated January 11, 1999 provided to
          the Company. Dr. Mates is the former President of the Company.

     (13) Includes 40,000 shares held by Mr. Abdun-Nabi's  spouse, for which Mr.
          Abdun-Nabi disclaims beneficial ownership.



                                      -10-
<PAGE>


SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

       Section  16(a) of the  Securities  Exchange Act of 1934,  as amended (the
"1934 Act"),  requires the  Company's  executive  officers  and  directors,  and
persons who own more than ten percent of the  Company's  Common  Stock,  to file
initial  reports of ownership  and reports of changes in ownership  with the SEC
and the  American  Stock  Exchange  (the  "AMEX"),  the  exchange  on which  the
Company's Common Stock is listed for trading. Executive officers,  directors and
greater than ten-percent  shareholders  (collectively,  the "Reporting Persons")
are  required  by SEC  regulations  to furnish  the  Company  with copies of all
Section 16(a) forms they file.

       Based  solely on review of the  copies  of such  forms  furnished  to the
Company, and written  representations by the Reporting Persons received to date,
the Company  believes that with respect to the year ended December 31, 1998, all
Section 16(a) filing requirements  applicable to the Reporting Persons were met,
except that (i) one monthly report, covering twelve transactions, was not timely
filed by Sharon Mates, a director and the former  President of the Company whose
employment  with the Company  terminated in September 1998, and (ii) one initial
report,  covering one  transaction  relating to the hiring of Randal D. Chase as
President  and Chief  Executive  Officer was filed late.  As of the date of this
proxy statement,  the Company is not aware of any other exceptions;  however, it
should  be noted  that  the  filing  date for  annual  statement  of  beneficial
statements  on Form 5 is  February  14,  1999,  which is  after  the date of the
mailing of this proxy statement.









                                      -11-
<PAGE>


COMPARATIVE STOCK PERFORMANCE

       The graph below  compares the  cumulative  total return of the  Company's
Common Stock (as traded on the AMEX) against the cumulative  total return of the
S&P 500  Composite  Stock  Index and the AMEX  Biotechnology  Index for the five
years ended December 31, 1998.

       The phrase "total  cumulative  return"  assumes that $100 was invested on
December 31, 1993 in the  Company's  Common Stock and in each index and that all
dividends were reinvested during the specified periods. The price performance of
the Company's  Common Stock shown below should not be viewed as being indicative
of future performance.

[LINEGRAPH: COMPARATIVE STOCK PERFORMANCE GRAPH PLOT POINTS:

                               1993    1994     1995     1996     1997    1998
                               ----    ----     ----     ----     ----    ----

North American Vaccine, Inc.    100      76      128      222      227      81
S&P 500 Composite Index         100     101      139      171      229     294
AMEX Biotechnology Index        100      70      115      124      140     160]


       The  graph  above  shall  not be  deemed  to be  soliciting  material  or
incorporated by reference by any general  statement  incorporating  by reference
this  Proxy  Statement  into any filing  under the  Securities  Act of 1933,  as
amended (the "1933 Act"), or the 1934 Act, except to the extent that the Company
specifically  incorporates  this  information by reference,  and it shall not be
otherwise deemed filed under such acts.



                                      -12-
<PAGE>


                                EXECUTIVE COMPENSATION

SUMMARY COMPENSATION TABLE

       The  following  table sets forth the cash and non-cash  compensation  for
each of the last  three  fiscal  years  awarded to (1) the  President  and Chief
Executive Officer, (2) the four other most highly compensated executive officers
of the Company for the year ended December 31, 1998 and (3) the Company's former
president (collectively, the "Named Officers").

<TABLE>
<CAPTION>

                                                                            LONG-TERM
                                            ANNUAL COMPENSATION           COMPENSATION
                                 ---------------------------------------  ------------
                                                                             AWARDS
                                                                             ------
                                                                            SECURITIES
                                                           OTHER ANNUAL     UNDERLYING       ALL OTHER
    NAME AND                            SALARY    BONUS   COMPENSATION(1)     OPTIONS      COMPENSATION(2)
PRINCIPAL POSITION               YEAR    ($)       ($)          ($)            (#)              ($)
- ------------------               ----   ------    ------  ---------------   -----------    --------------
<S>                              <C>    <C>           <C>        <C>        <C>               <C>

Randal D. Chase, Ph.D.           1998   $32,778 (3)    --         --         250,000            $104
  President & Chief Executive    1997      --          --         --             --              --
  Officer                        1996      --          --         --             --              --

Arthur Y. Elliott, Ph.D.         1998   283,000        --         --          37,500           5,623
  Senior Vice President -        1997   283,000        --         --          37,500           5,374
  Operations & Chief Operating   1996   262,080        --         --             --            5,224
  Officer

Daniel J. Abdun-Nabi             1998   224,100        --         --          25,000           5,623
  Senior Vice President -        1997   224,100        --         --          37,500 (4)       5,374
  Legal Affairs & General        1996   207,480        --         --             --            5,224
  Counsel

Wayne Morges, Ph.D.              1998   215,700        --         --          25,000           5,623
  Vice President -               1997   215,700        --         --          25,000           5,374
  Quality/Regulatory Affairs     1996   199,680        --         --             --            5,224

Edward Arcuri, Ph.D.             1998   213,400        --         --          25,000             623
  Vice President -               1997   213,400        --         --          25,000             624
  Manufacturing Operations       1996   197,600        --         --             --              474

Sharon Mates, Ph.D. (5)          1998   269,554       --         --              --            4,223
  Former President               1997   350,000 (6)   --         --           80,000           5,374
                                 1996   283,920    $50,000 (7)   --              --  (8)       5,224
</TABLE>

- -------------------



                                      -13-
<PAGE>


(1)   For 1998, 1997 and 1996, the aggregate  amount of  perquisites,  and other
      personal  benefits,  securities  or property for each Named Officer is not
      reportable  under SEC rules  because  such  amount is the lesser of either
      $50,000 or 10% of the total annual salary for each such Named Officer.

(2)   Amounts  of  All  Other   Compensation  for  1998  includes  (i)  matching
      contributions  made by the Company in fiscal  1998 to the Named  Officer's
      retirement account under the North American Vaccine,  Inc.  Retirement and
      Savings 401(k) Plan and Trust ($5,000 for Drs.  Elliott and Morges and Mr.
      Abdun-Nabi  and  $3,750  for  Dr.  Mates)  and  (ii)  the  Company's  cost
      allocation of supplemental  term life insurance ($104 for Dr. Chase,  $623
      for Drs.  Elliott,  Morges  and Arcuri  and Mr.  Abdun-Nabi,  $468 for Dr.
      Mates).  The matching 401(k)  contributions  have been made in the form of
      the Company's Common Stock and are included in the table under the heading
      "Security Ownership of Certain Beneficial Owners and Management."

(3)   Dr. Chase was first employed by the Company in November  1998.  Represents
      salary earned in 1998 and paid in 1999.

(4)   In addition to the grant of a new option to purchase  37,500 shares of the
      Company's  Common Stock under the  Company's  1995 Share Option Plan,  Mr.
      Abdun-Nabi  was  granted a five-year  extension  of a  previously  granted
      option to purchase  150,000 shares of the Company's Common Stock under the
      Company's former Share Option Plan, which option was originally  scheduled
      to expire on March 18,  1997.  No other terms of the option were  changed.
      The extension was effective as of March 6, 1997.

(5)   Dr. Mates was removed as President as of September 23, 1998.

(6)   Includes  $35,000  adjustment to 1997 salary that was  determined and paid
      during 1998.

(7)   Bonus determined and paid in 1997 for performance during 1996.

(8)   In 1996,  Dr.  Mates was granted an  18-month  extension  of a  previously
      granted option to purchase  270,000  shares of the Company's  Common Stock
      under the Company's  former Share Option Plan, which option was originally
      scheduled to expire on October 30, 1996. No other terms of the option were
      changed. The extension was effective as of April 14, 1996.






                                      -14-
<PAGE>


OPTION GRANTS IN LAST FISCAL YEAR

      The following table sets forth certain information  concerning  individual
grants and  extensions  of stock options made to the Named  Officers  during the
year ended December 31, 1998. The Company has not granted any stock appreciation
rights ("SARs").

<TABLE>
<CAPTION>
                                       INDIVIDUAL GRANTS                     POTENTIAL REALIZABLE VALUE
                     ----------------------------------------------------      AT ASSUMED ANNUAL RATES
                     NUMBER OF        % OF                                   OF STOCK PRICE APPRECIATION
                     SECURITIES    TOTAL OPTIONS                                 FOR OPTION TERM(1)
                     UNDERLYING     GRANTED TO     EXERCISE                  ---------------------------
                      OPTIONS      EMPLOYEES IN    OR BASE     EXPIRATION
     NAME           GRANTED(2)(3)  FISCAL YEAR      PRICE        DATE             5%           10%
     ----           ------------   ------------     -----      ----------    ---------------------------
                        (#)          ($/sh)
<S>                    <C>            <C>         <C>         <C>            <C>           <C>       

     Randal D. Chase   250,000        26.6%       $10.625     10/13/2008     $1,670,500    $4,233,378

     Arthur Y. Elliott  37,500         4.0%        $8.75      12/09/2008        206,356       522,947

     Daniel J.
       Abdun-Nabi       25,000         2.7%        $8.75      12/09/2008        137,571       348,631

     Wayne Morges       25,000         2.7%        $8.75      12/09/2008        137,571       348,631

     Edward Arcuri      25,000         2.7%        $8.75      12/09/2008        137,571       348,631

     Sharon Mates          --          --           --            --               --            --
</TABLE>

- ----------------------
    (1)   Gains are reported net of the option exercise price,  but before taxes
          associated  with exercise.  These amounts  represent  certain  assumed
          rates of appreciation only, based on the per share market price on the
          date of grant and an annual  appreciation  at the rate stated  through
          the  expiration  date of the option.  Actual  gains,  if any, on stock
          option  exercises  are  dependent  on the  future  performance  of the
          Company's   Common   Stock,   overall   market   conditions   and  the
          optionholder's  continued  employment  through the vesting period. The
          amounts reflected in this table may not necessarily be achieved.

    (2)   All options were granted under the Company's 1997 Share Option Plan at
          fair  market  value  and  vest  in  three  equal  annual  installments
          commencing one year after the date of grant.



                                      -15-
<PAGE>

    (3)   In the event of a change of control of the Company, the exercisability
          of each option shall be  automatically  accelerated  so that each such
          option outstanding shall, immediately prior to the specified effective
          date of a change of control,  becomes fully exercisable for all shares
          subject to the option.  The events that trigger an acceleration of the
          options'  exercisability  are:  (i) a third party  acquires  direct or
          indirect  ownership  of fifty  percent  (50%) or more of the  combined
          voting  power of the  Company's  then  outstanding  securities  of the
          Company;  (ii) any  election  has  occurred of persons to the Board of
          Directors of the Company that causes two-thirds of the Company's Board
          of  Directors  to consist of persons  other than (A)  persons who were
          members of the Company's Board of Directors on January 1, 1997 and (B)
          persons who were  nominated by the  Company's  Board of Directors  for
          election as members of the Company's Board of Directors at a time when
          two-thirds  of the Company's  Board of Directors  consisted of persons
          who were  members of the  Company's  Board of  Directors on January 1,
          1997; provided, however, that any person nominated for election by the
          Board  of  Directors  of the  Company  at  least  two-thirds  of  whom
          constituted  persons  described  in clauses (A) and/or (B) above or by
          persons who were  themselves  nominated by such Board shall,  for this
          purpose,  be deemed  to have been  nominated  by a Board  composed  of
          persons  described in clause (A) above;  or (iii) the  shareholders of
          the  Company  approve  (A)  any  statutory  consolidation,  merger  or
          amalgamation  of the Company in which the Company is not the surviving
          corporation  (other  than a merger or  amalgamation  of the Company in
          which the holders of shares of Common Stock  immediately  prior to the
          merger or amalgamation  have the same  proportionate  ownership of the
          surviving  corporation  immediately after the merger or amalgamation),
          or (B) any sale, lease, exchange or other transfer (in one transaction
          or a series of related  transactions) of all, or substantially all, of
          the  assets of the  Company  to an entity  that is not a  wholly-owned
          subsidiary of the Company.












                                      -16-
<PAGE>


AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
AND FISCAL YEAR-END OPTION VALUES

  The following table summarizes the value realized by any of the Named Officers
who exercised  options  under the  Company's  former Share Option Plan in fiscal
1998, as well as the number and value of unexercised  options held by each Named
Officer as of December 31, 1998. As the Company has not issued any SARs, no SARs
were exercised.

<TABLE>
<CAPTION>
                                                    NUMBER OF SECURITIES                VALUE OF UNEXERCISED
                                                   UNDERLYING UNEXERCISED               IN-THE-MONEY OPTIONS
                                                OPTIONS AT FISCAL YEAR-END               AT FISCAL YEAR-END (1)
                       SHARES                   --------------------------              -----------------------
                      ACQUIRED ON    VALUE
     NAME              EXERCISE    REALIZED    EXERCISABLE  UNEXERCISABLE EXERCISABLE     UNEXERCISABLE
     ----             -----------  --------    -----------  ------------- -----------     -------------
                         (#)          ($)          (#)          (#)          ($)               ($)
<S>                      <C>      <C>            <C>            <C>       <C>             <C>

     Randal D. Chase    --        $   --           --           250,000   $   --          $  --

     Arthur Y. Elliott  --            --         187,500         62,500       --           4,688

     Daniel J.
       Abdun-Nabi      10,000      106,250       212,500         50,000       --           3,125

     Wayne Morges       --            --          70,252         41,667       --           3,125

     Edward Arcuri      --            --          83,333         41,667       --           3,125

     Sharon Mates     219,037      974,317        76,666          --          --             --
</TABLE>

- ---------------------------
    (1) Values  based only on (i) the number of options  for which the  exercise
        price  was  equal  to or less  than  $8.875  (the  closing  price of the
        Company's  Common  Stock on the AMEX on December  31, 1998) and (ii) the
        difference between such closing price and such options' exercise price.





                                      -17-
<PAGE>


COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

      The following report of the Company's  Compensation Committee shall not be
deemed to be  soliciting  material or  incorporated  by reference by any general
statement  incorporating by reference this Proxy Statement into any filing under
the 1933 Act or the 1934 Act, except to the extent that the Company specifically
incorporates this information by reference, and it shall not be otherwise deemed
filed under such acts.

To the Company's Shareholders:

      The Compensation  Committee of the Company's Board of Directors is charged
with  reviewing  and  approving  the  compensation  of the  Company's  executive
officers,  as well as any  other  employees  earning  $130,000  or more per year
(individually,  a "Senior  Manager"  and,  collectively,  "Senior  Management").
However,  the President's cash  compensation is subject to final approval of the
entire Board of Directors.  For these purposes,  compensation includes salaries,
benefits,  stock  options  and any other forms of  remuneration  approved by the
Compensation   Committee.   The  objectives  of  the  Compensation   Committee's
compensation program are three-fold:

      o     to create incentives to achieve outstanding corporate and individual
            performance,
      o     to align Senior  Management's  interests with those of the Company's
            stockholders through potential stock ownership, and
      o     to  assist  the  Company  in  attracting  and  retaining   qualified
            management by providing competitive levels of compensation.

      COMPONENTS  OF  SENIOR  MANAGEMENT  COMPENSATION.  Consistent  with  these
objectives  and the  long-term  focus  required  at this stage of the  Company's
development,  the  Compensation  Committee  believes  that  a  Senior  Manager's
compensation  should consist of a reasonable  cash salary and meaningful  equity
incentives in the form of stock option grants, because the ultimate value of the
options is tied to long-term  corporate  development  and  enhanced  shareholder
value.

      Salaries for Senior Management are initially  determined by evaluating the
responsibilities of the position held and the experience of the individual.  The
competitive  marketplace for management  talent is also considered.  Thereafter,
the President, with the assistance of other members of Senior Management,  makes
annual  salary  recommendations  for each  Senior  Manager  to the  Compensation
Committee.  The Compensation  Committee reviews these  recommendations and makes
appropriate modifications. The Compensation Committee sets final annual salaries
for Senior Management.

      Senior Managers  establish  annual goals and objectives  (subject to their
respective  supervisor's  approval)  against  which  they  are  evaluated.   The
Compensation  Committee  also measures the  performance  of each Senior  Manager
against any increased  responsibilities assumed. Further adjustments are made to
reflect an assessment of the Company's  performance in relation to its strategic
and  operational  goals,  as well as with its economic  performance,  giving due
consideration to its stage of development. This assessment considers the quality
and measured progress of the Company's:





                                      -18-
<PAGE>



      o     research and development program,
      o     manufacturing and related operations,
      o     regulatory approval process, and
      o     success  with  strategic  actions  such  as  corporate   financings,
            research and development agreements, corporate alliances and similar
            relationships.

      Based on the foregoing,  principally the  later-than-expected  approval of
Certiva(TRADEMARK)  (the Company's unique triple toxoid diphtheria,  tetanus and
acellular  pertussis  vaccine),  the Compensation  Committee did not approve any
increases in 1998 salaries for Senior Management. Except as described below with
respect to the compensation  package for the Company's  current and former chief
executive  officers,  the Compensation  Committee has not, to date,  established
specific performance goals or tied executive  compensation to the achievement of
specific performance goals.

      Stock option grants  represent a long-term  incentive  program designed to
link over time Senior Management compensation with stockholder value. Because of
the long time  horizons  required  for  returns  on  investments  and  strategic
decisions in  companies  competing  in the vaccine  business,  these grants also
serve to focus Senior  Management's  attention on the Company's long-term needs.
Generally,  stock  options are awarded to Senior  Managers at the time that they
join the Company  and  periodically  thereafter.  The  Compensation  Committee's
intent is to immediately  align the interests of Senior Management with those of
the Company's  shareholders  through the initial stock option grant. Options are
only  granted  subsequently  on an  intermittent  basis in  furtherance  of this
philosophy,  taking into  account the number of stock  options then held by each
Senior  Manager.  If  necessary to retain a member of Senior  Management,  stock
option grants may also be made in amounts that,  when  aggregated with the other
forms of compensation mentioned above, will be, in the Compensation  Committee's
subjective judgment, fair and competitive.

      Grants of stock options are generally made upon the recommendations of the
chief executive officer.  However, the actual number of stock options granted is
determined by the Compensation  Committee's  subjective  analyses of each Senior
Manager's  function,  salary,  length of service,  performance  and value to the
Company.  No specific  weight is given as to any of these  factors.  All options
granted to Senior  Managers are made at the then current  market price.  Options
granted under the Company's  current share option plans  generally  first become
exercisable  one year  after  grant  and vest  over a  three-year  period.  They
generally expire ten years following the date of grant.  Generally,  options may
be  exercised  only so long as the  optionee  is an  employee  of the Company or
within the twelve-month period following termination of employment.

      CHIEF EXECUTIVE OFFICER'S  COMPENSATION.  These same compensation policies
were applied by the  Compensation  Committee to Dr.  Sharon  Mates,  who, in the
capacity of President,  served as the Company's chief executive  officer through
September  23, 1998.  The  Compensation  Committee  did not approve for 1998 any
increase  in Dr.  Mates'  salary or the  grant of any  additional  options.  The
Compensation  Committee  recommended this action after  evaluating,  among other
things,  Dr.  Mates'  accomplishments  for  1997  and  1998,  and the  Company's
performance  in relation  to its  strategic,  operational  and  economic  goals,
including  the timing of FDA  approval  for  Certiva(TRADEMARK).  In April 1998,
however, the Company made a loan to Dr. Mates in connection with the exercise of
expiring stock options,  which had been extended previously for an additional 18
months. The loan was comprised of approximately $1.0 million for the exercise of
the options and $217,000 for payment of withholding  taxes. The loan was made on
a full  recourse  basis,  was for a  six-month  period,  was  collateralized  by
approximately 94,000 shares of Company's Common Stock, which at the time of the


                                      -19-
<PAGE>


loan had a fair market value of 125% of the  principal  amount of the loan.  The
loan  accrued  interest  at a fair market  rate.  The loan was repaid in full at
maturity during October, 1998, and the collateral has been released. As a matter
of policy,  the Company generally does not extend loans to executive officers of
the Company for any purpose,  including the exercise of stock options.  However,
the Compensation  Committee,  under unusual  circumstances and on a case-by-case
basis,  occasionally will consider the advisability of extending such loans. The
loan to Dr. Mates was extended to permit her to exercise the options prior their
expiration and pay the associated tax obligations  without having to sell shares
of Common Stock in the open market.

      In October 1998,  the Company  appointed Dr. Randal Chase as the Company's
President  and Chief  Executive  Officer  (see the  biography of Dr. Chase above
under  "Election  of  Directors").  At that  time,  the  Compensation  Committee
approved the following compensation package for Dr. Chase:

      o     an annual salary of $200,000,
      o     an annual bonus  targeted at $80,000 to be based on his  performance
            in meeting  specific goals  established by Dr. Chase and approved by
            the Compensation Committee,
      o     the grant of an option to purchase  250,000  shares of the Company's
            Common Stock,
      o     a cash bonus to be paid if the Company is sold,  which bonus  amount
            is  based  on  the  per  share  value  of  the  stock  in  any  sale
            transaction, up to $1,000,000, and
      o     certain other perquisites,  including,  among other things, housing,
            moving and car allowances.

      If Dr. Chase is taxed by both Canadian and U.S.  authorities,  the Company
will pay Dr.  Chase any excess tax paid above  taxes  payable  based on Canadian
rates. The Compensation  Committee  recommended this compensation  package after
evaluating   (i)  Dr.   Chase's   skill  and   experience  in  the  vaccine  and
pharmaceutical  industry  and (ii) the  compensation  packages of officers  with
similar  responsibilities  at selected  biotechnology  companies.  The  selected
companies,  which  are  not  necessarily  representative  of  the  biotechnology
industry  as a whole  or  companies  similarly  situated  to the  Company,  were
subjectively  selected by the  Compensation  Committee  based on factors such as
size in terms of assets, employees and market capitalization,  status of product
pipeline,  and such other factors as the Compensation  Committee determined,  in
its subjective judgment, to be appropriate.

      The  Company  is  generally  denied a  deduction  for  federal  income tax
purposes  for  compensation  over $1  million  paid in any  taxable  year to the
Company's  chief  executive  officer  or any  of  its  four  other  most  highly
compensated   executive   officers.   However,   qualifying   performanced-based
compensation  is not  subject  to the  limitation  if certain  requirements  are
satisfied. Based on the rules under the law, the Company believes that grants of
options under the  Company's  stock option plans are exempt from this $1 million
cap. Accordingly,  the Company does not expect compensation to any individual to
be in excess of $1 million in fiscal 1999 for  purposes  of this tax law.  While
the Company  does not have a policy that  requires all  compensation  payable in
fiscal 1999 and thereafter to be deductible  under Section  162(m),  the Company
does not expect compensation to any individual to be in excess of $1 million for
fiscal 1999 and will endeavor,  whenever possible without distorting  incentives
for performance to enhance the value of the Company, to cause compensation to be
structured so that all of it will be tax deductible.




                                      -20-
<PAGE>


      As the  Compensation  Committee  considers  it  important  to  retain  the
flexibility  to design  compensation  programs that are in the best interests of
the  Company  and  its   shareholders,   it  is  continually   evaluating  those
compensation programs and procedures with respect to Senior Management.


January 22, 1999                    Compensation Committee

                                    Jonathan Deitcher, Chairman
                                    Alain Cousineau
                                    Denis Dionne

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

      The current members of the Compensation  Committee for the Company's Board
of Directors are Jonathan Deitcher (Chairman), Alain Cousineau and Denis Dionne.
No member of the  Compensation  Committee  is a current  employee or a former or
current officer of the Company or any of its  subsidiaries.  Denis Dionne is the
president of Sofinov,  which purchased the aggregate  principal  amount of $6.25
million of the 4.5%  Convertible  Secured  Notes in the  Company's  $25  million
financing  completed  in November  1998.  See  "Certain  Transactions  - Private
Placement of Convertible Secured Notes."


                                 CERTAIN TRANSACTIONS
MERGER

      The  transaction,  whereby  certain  vaccine  technologies  of BioChem and
American  Vaccine  Corporation,   the  predecessor  to  the  Company  ("American
Vaccine"),  were combined into the Company, was consummated on February 28, 1990
(the "Merger").  As a result of the Merger, BioChem currently holds Common Stock
of the Company, Series A Preferred Stock of the Company, and options to purchase
Common Stock,  which  options may only be exercised  when and to the extent that
the matching  options  issued to former option  holders of American  Vaccine are
first exercised.  In the Merger, BioChem issued shares to the Company,  together
with cash and  certain  vaccine  technologies.  In the  Merger,  the Company and
BioChem  granted  to each  other a  one-time  demand  registration  right  (with
expenses to be paid by the party exercising the registration  right) and certain
piggy-back  registration  rights. The piggy-back  registration rights expired on
January 17,  1995 and the demand  registration  right,  which was  scheduled  to
expire as of January 17, 1998,  was amended in January 1998 to extend that right
until January 17, 2001.

      A  shareholders'  agreement (the  "Shareholders'  Agreement") was executed
between Dr. Frost,  Frost-Nevada and IVAX (collectively,  the "Frost Group") and
BioChem as part of the Merger. Under the Shareholders' Agreement, both the Frost
Group and BioChem  agreed to nominate an equal number of directors  for election
to the Board of  Directors  of the Company,  and such  nominees  then select one
additional nominee satisfactory to both groups of nominees.  The Frost Group and
BioChem agreed to vote all of their  respective  shares of the Company's  Common
Stock to elect to the Board of Directors  all of the  nominees so selected.  The
combination  of the  voting  power of the  Frost  Group  and  BioChem  under the
Shareholders'  Agreement gives them effective control of the Company and enables
them to determine  the policies and direct the  operations  of the Company.  The


                                      -21-
<PAGE>

Shareholders' Agreement also grants the Frost Group and BioChem mutual rights of
first refusal with respect to the sale, transfer or other similar disposition of
any of their  shares of the  Company's  Common  Stock,  the  Company's  Series A
Preferred  Stock or other  securities of the Company held directly or indirectly
by either of them.  Such  rights of first  refusal  do not  apply,  however,  to
transfers of such  securities by the Frost Group or BioChem to their  respective
affiliates.  The Shareholders' Agreement will terminate on February 28, 2000. In
addition,  in the event that either BioChem or the Frost Group ceases to hold an
aggregate of 50% or more of the Company's  Common Stock,  the Company's Series A
Preferred Stock and other Company  securities  owned by it on February 28, 1990,
the selling party will lose its rights of first refusal under the  Shareholders'
Agreement and the provisions thereunder regarding the nomination and approval of
nominees to the Board of Directors of the Company will lapse.

      In connection  with the Merger,  Frost-Nevada,  IVAX and a former  officer
(collectively, the "Indemnitees"),  all of whom beneficially owned, at the time,
more than 5% of the outstanding capital stock of American Vaccine,  entered into
an Indemnification Agreement with the Company (the "Indemnification Agreement"),
pursuant to which the Company  agreed to indemnify the  Indemnitees  against any
United States  federal,  state and local income tax  liabilities  that may arise
under  prescribed  "gain  recognition  agreements"  that  the  Indemnitees  were
required to file with the United States Internal  Revenue Service and that would
require the Indemnitees to recognize gain upon the occurrence of certain events.
Such gain  recognition  agreements  generally would require that the Indemnitees
recognize  gain (and file  amended tax  returns) if the Company  sells  American
Vaccine stock that it acquired as a result of the Merger or if American  Vaccine
sells all or substantially  all of its assets (other than in the ordinary course
of business)  during the period  commencing on the date of  consummation  of the
Merger and ending December 31, 2000. Under the  Indemnification  Agreement,  the
Company  agreed to (i) lend the  Indemnitees on an  interest-free  and after-tax
basis, an amount equal to the taxes to be paid with the amended tax returns, and
(ii) pay the Indemnitees, on an after-tax basis, any interest and penalties with
respect to the taxes to be paid with the amended returns. However,  repayment of
these  loans  will  only be  required  at the  time and to the  extent  that the
Indemnitees  receive  benefit  from the  resulting  increase in the tax basis of
their Common Stock or Series A Preferred  Stock.  There can be no assurance that
any such benefit  will be received.  Under the  Indemnification  Agreement,  the
Company's  directors  nominated  by the Frost Group,  with the  exception of Dr.
Frost, will not be precluded from voting upon a transaction that could give rise
to the Company's indemnification obligations to the Indemnitees. The affirmative
vote of 75% of all of the Company's  directors,  excluding  Dr.  Frost,  will be
required  to approve  any  transaction  that could  require  the  payment of any
indemnity  pursuant  to the  Indemnification  Agreement.  No  payments  would be
triggered under the Indemnification Agreement arising out of a tender offer for,
or a business combination involving, all of the Company's Common Stock.

PRIVATE PLACEMENT OF CONVERTIBLE SECURED NOTES

      In November 1998, the Company  completed a $25 million  financing  through
the private placement of 4.5% Convertible Secured Notes ("4.5% Notes").  BioChem
and Dr. Frost, affiliates of the Company,  purchased 4.5% Notes in the aggregate
principal  amount of $9 million and $4.25  million,  respectively.  In addition,
Sofinov purchased 4.5% Notes in the aggregate principal amount of $6.25 million.
Denis Dionne, a director of the Company, is the President of Sofinov.

      The 4.5% Notes were sold at par,  mature on November  13, 2003 and provide
for  interest  payable  semi-annually  on May 13 and  November  13 of each  year
commencing on May 13, 1999. The 4.5% Notes are convertible, in whole or in part,
by the holder(s) at any time prior to maturity  (unless  previously  redeemed or
repurchased)  into shares of the Company's Common Stock at a conversion price of


                                      -22-
<PAGE>

approximately $8.54 per share. The conversion price was set based on the average
closing  price of the  Company's  Common  Stock for the twenty (20) trading days
preceding the date of the announcement of the agreement-in-principle between the
Company and prospective  purchasers.  The measurement period for determining the
conversion  price began on August 26, 1998 and terminated on September 23, 1998.
The closing prices of the Company's  Common Stock during that period ranged from
a low of $6.875  and a high of  $11.25.  The 4.5%  Notes are  secured by certain
assets of the Company,  are  otherwise  subordinated  in right of payment to all
existing and future  senior  indebtedness  of the  Company,  do not restrict the
incurrence  of  future  senior  or other  indebtedness  of the  Company  and are
redeemable,  in whole or in part,  at the option of the  Company on or after one
year from the date of issuance at par, plus accrued  interest to the  redemption
date. Upon a change in control, the Company is required to offer to purchase all
of the 4.5% Notes then  outstanding  at a  purchase  price  equal to 100% of the
principal amount thereof, plus interest. The repurchase price will be payable in
cash or, at the option of the Company,  in shares of the Company's  Common Stock
(valued at 95% of the average closing prices of the Common Stock for a specified
period prior to the repurchase date).

      The 4.5%  Notes are not  registered  under the 1933 Act or any  applicable
state or  foreign  securities  laws,  and were sold in  reliance  on  prescribed
exemptions from  registrations  under the 1933 Act and other applicable state or
foreign securities laws.

      On November  12, 1998,  the date on which the 4.5% Notes were issued,  the
closing price of the Company's Common Stock was $12.625.  As this price exceeded
the conversion price for the 4.5% Notes, the Company recognized an approximately
$12 million beneficial conversion feature, which was recorded as paid-in capital
in the  fourth  quarter of 1998.  The amount  recorded  to paid-in  capital  was
calculated  by  multiplying  the  total  number  of shares  then  issuable  upon
conversion of the 4.5% Notes by the difference  between the closing price on the
issuance date and the conversion  price.  This discount also was deemed to be an
increase in the  effective  interest rate of the 4.5% Notes to be reflected as a
charge to interest  expense and amortized over the period from the issuance date
to the date the 4.5% Notes first become  convertible.  Given that the 4.5% Notes
are immediately  convertible,  the Company  recognized a corresponding  one-time
interest charge of approximately $12 million in the fourth quarter of 1998. This
interest expense is not deductible for U.S. or Canadian income tax purposes.

      On November 2, 1998,  Sharon Mates,  Ph.D.,  a director of the Company and
the Company's former president,  initiated  litigation in United States District
Court,  District of Maryland  (Civil  Action No. AW 98-3678)  (the  "Complaint")
against the Company,  two of its directors and BioChem.  The claims  against the
Company seek principally the following:  declaratory  relief against the Company
regarding  the approval and  consummation  of the private  placement of the 4.5%
Notes;  injunctive  relief seeking to prevent the Company from  consummating the
private  placement  of the 4.5%  Notes;  injunctive  relief  against the Company
relating to Dr.  Mates' access to Company books and records and to her continued
service  as  a  director;   declaratory  relief  regarding  the  termination  of
employment  and removal as  president  of the  Company;  and claims  against the
Company  alleging  abusive  discharge and  defamation.  The Complaint also seeks
actual and punitive  damages  against the Company in an unspecified  amount.  In
addition,  the Complaint  seeks  declaratory  and injunctive  relief against Dr.
Frost  and  BioChem   arising  out  of  alleged   violations  of  the  reporting
requirements of Sections 13(d) and Rule 13d-1(a) of the 1934 Act and unspecified
damages from  BioChem and Drs.  Frost and  Francesco  Bellini  (chief  executive
officer of BioChem) for tortious interference with Dr. Mates' business relations
with the Company.



                                      -23-
<PAGE>

      In December  1998,  the Company filed a motion to dismiss the Complaint in
its  totality.  BioChem and Drs.  Frost and Bellini  have also filed  motions to
dismiss Dr. Mates' claims. The Company intends to continue to vigorously contest
and defend against the claims in this litigation.  The Company believes that the
claims against it are without merit,  that the Company has meritorious  defenses
available to it, and that certain claims may be covered by insurance.  Under the
terms of the Company's  By-laws and  indemnification  agreements with directors,
the Company is obligated to indemnify  directors  against  certain  claims.  The
Company is presently  evaluating the extent of its  indemnification  obligations
and available  insurance  coverage.  In the opinion of management,  this lawsuit
will not have a material adverse effect on the Company. If, however,  litigation
costs,  including  indemnification   obligations,   and  judgments  against  the
defendants exceed the Company's available  insurance  coverage,  this litigation
could have a material  adverse effect on the Company's  financial  condition and
results of operations.

OTHER MATTERS

      In April 1998,  the  Company  extended a loan to its then  president,  Dr.
Mates, in connection  with the exercise of expiring stock options.  The loan was
comprised  of  approximately  $1.0  million for the  exercise of the options and
$217,000 for payment of withholding  taxes. The loan was made on a full recourse
basis, was for a six-month period,  was  collateralized by approximately  94,000
shares  of  Company's  Common  Stock,  which  at the time of the loan had a fair
market  value of 125% of the  principal  amount  of the loan.  The loan  accrued
interest at a fair market rate.  The loan was repaid in full at maturity  during
October, 1998, and the collateral has been released.


                            APPROVAL OF THE COMPANY'S
        1999 NON-EMPLOYEE DIRECTOR AND SENIOR EXECUTIVE STOCK OPTION PLAN
                                (PROPOSAL NO. 2)

      The Company's 1999 Non-Employee Director and Senior Executive Stock Option
Plan (the "1999 SESOP") is being  proposed to  shareholders  to replace the 1995
SESOP,  which,  following the automatic  grant of shares on January 1, 1999, now
has  insufficient  number  of  authorized  shares  to  continue  the  policy  of
compensating  non-employee  directors  through  the  automatic  grant  of  stock
options.  The Board of Directors  adopted the 1999 SESOP at a meeting on January
25, 1999, subject to the approval of the Company's shareholders.  If a quorum is
present,  an  affirmative  vote of the  majority of votes  actually  cast at the
Meeting is required to approve the 1999 SESOP.

      The 1999 SESOP is designed to comply with the  requirements  of Rule 16b-3
promulgated  under the 1934 Act, and the Company  intends  that options  granted
under the 1999 SESOP will  qualify for an  exception  to the rule  limiting  the
deductibility  of executive  compensation  under Section  162(m) of the Internal
Revenue  Code of 1986,  as  amended  (the  "Code").  Section  162(m)  limits the
deductibility  of compensation  over $1 million paid to the Company's  President
and its four  other most  highly  compensated  executive  officers  unless  that
compensation is performanced-based and the plans under which the compensation is
paid are approved by the  shareholders.  Shareholder  approval of the 1999 SESOP
should permit  deductibility  under Section  162(m) of the Code of  compensation
attributable  to stock  options.  The 1999 SESOP will not be put into  effect if
shareholder approval is not obtained.



                                      -24-
<PAGE>

      A summary of the essential  features of the 1999 SESOP is provided  below,
but is  qualified  in its  entirety  by  reference  to the full text of the 1999
SESOP, which is attached as Exhibit A to this Proxy Statement.

DESCRIPTION OF 1999 SESOP

      PURPOSE.  The purpose of the 1999 SESOP is to attract,  keep and  motivate
the Company's  non-employee  directors and Senior  Executives (as defined below)
who are  residents  of Canada.  The 1999 SESOP is not  qualified  under  Section
401(a)  of the  Code,  and is not  subject  to any  provisions  of the  Employee
Retirement Income Security Act of 1974, as amended ("ERISA").

      SHARES  AVAILABLE  FOR  ISSUANCE.  The total  number of shares that may be
issued under stock options granted  pursuant to the 1999 SESOP is 650,000 shares
of the Company's Common Stock,  which may be newly issued or treasury shares. As
of January 25, 1999,  the 650,000  shares  reserved for issuance  under the 1999
SESOP had an aggregate market value of $4,550,000 (based on the closing price of
the Company's Common Stock on the AMEX as of such date). No Senior Executive may
receive stock options under the 1999 SESOP in any calendar year to purchase more
than one percent the shares of Common  Stock  issued and  outstanding  as of the
first day of that  calendar  year.  If an option  should  expire,  terminate  or
otherwise become  unexercisable  for any reason without having been exercised in
full, the unpurchased  shares will become  available for further grant under the
1999 SESOP.

      ADMINISTRATION. The 1999 SESOP is administered by a committee of the Board
of Directors (the "Committee"), which must consist of at least two directors who
are  "non-employee  directors" as defined under Rule 16b-3 promulgated under the
1934 Act and who are  "outside  directors"  as defined  for  purposes of Section
162(m) of the Code. Currently, the Compensation Committee of the Company's Board
of Directors administrates the 1999 SESOP.

      Subject to the  provisions of the 1999 SESOP,  the Committee is authorized
to  interpret  the 1999  SESOP,  to  prescribe,  amend,  and  rescind  rules and
regulations  relating  to the 1999 SESOP,  and to make all other  determinations
necessary or advisable for the  administration of the 1999 SESOP. This includes,
without limitation,  (i) accelerating the vesting of any option already granted,
(ii)  determining  whether the exercise  price of or taxes relating to an option
may be paid in already owned shares of the Company's  Common Stock and/or shares
then issuable upon the exercise of the option,  (iii)  determining the terms and
provisions  of each  option  granted  under the 1999  SESOP  (which  need not be
identical), (iv) waiving or amend any and all restrictions and conditions of any
options,  including,  without limitation,  extending the term of any option, and
(v)  authorizing  any person to execute on behalf of the Company any  instrument
required  to  effectuate  the  grant  of an  option  previously  granted  by the
Committee.  All decisions,  determinations and  interpretations of the Committee
are  final,  conclusive  and  binding  on each  optionee.  Grants of  options to
residents of certain  Canadian  provinces  will require  regulatory  approval in
those provinces.

      TERM.  The 1999 SESOP will  continue in effect  until  January  25,  2009,
unless  earlier   terminated  by  the  Committee.   Each  option  granted  to  a
non-employee  director  will have a term of ten years.  The term of each  option
granted to a Senior  Executive  shall be set by the Committee but may not exceed
ten years.



                                      -25-
<PAGE>

      AUTOMATIC  GRANTS TO NON-EMPLOYEE  DIRECTORS.  Each member of the Board of
Directors  of the  Company  who is not an  employee of the Company or any of its
subsidiaries  qualifies  as a  non-employee  director.  Under  the  1999  SESOP,
non-employee  directors will receive automatic grants of options without further
action or  authorization  required by the Board of Directors or the Committee on
each January 1, commencing with January 1, 2000. Each non-employee director will
receive  automatically an option to acquire:  (i) 20,000 shares of the Company's
Common Stock if the  non-employee  director is the Chairman of the Board or Vice
Chairman of the Board;  (ii) 5,000 shares of the Company's  Common Stock for all
other non-employee  directors;  and (iii) 5,000 shares of Company's Common Stock
for each  committee of the Board of Directors  on which  non-employee  directors
(other than the Chairman and Vice Chairman of the Board) serve.

      OPTION GRANTS TO SENIOR EXECUTIVES.  Within the parameters  established by
the 1999 SESOP, the Committee  selects the Senior  Executives of the Company who
will be granted options,  the time at which an option may be granted, the number
of shares for which an option is granted,  the vesting  schedule for the option,
the term of the option and the exercise price per share of the option.  The 1999
SESOP  defines the term "Senior  Executive"  to mean any person  exercising  the
function of  president,  vice-president,  secretary,  treasurer,  controller  or
general  manager or similar  functions,  but shall not include a person who is a
director.  Only Senior  Executives  who are  residents of Canada are eligible to
receive options under the 1999 SESOP.

      OPTION PRICE.  The minimum option price for the purchase of stock pursuant
to any option granted to a Senior  Executive is 100% of the fair market value of
the stock at the time the option is granted.  The per share  option price for an
option  granted to a  non-employee  director is 100% of the fair market value of
the stock at the time the option is granted.  Fair  market  value is the closing
sale price of the Common Stock on the principal  securities exchange (or Nasdaq,
if  applicable)  on which the Common  Stock is then trading on the date of grant
or, if the there were no sales reported on that date, then on the last preceding
date on which the securities  exchange (or Nasdaq,  if applicable)  was open for
trading.  The  optionee  is  required  to pay for the  shares to be issued  upon
exercise of an option in cash or by check or by such other  consideration and in
such other manner as the Committee may accept,  which may include  shares of the
Company's Common Stock owned by the optionee.

      VESTING. Options automatically granted to non-employee directors will vest
in three equal annual  installments  commencing on the January 1 first following
the date of grant of the option.  Options granted to Senior Executives will vest
in accordance with the vesting schedule established by the Committee at the time
of grant.

      TERMINATION  OF  EMPLOYMENT  OR SERVICE.  Upon a  non-employee  director's
resignation or termination from the Board of Directors,  any option held by that
director is generally  exercisable,  to the extent that it is vested on the date
of resignation or  termination,  at any time prior to the expiration date of the
option.

      Upon  a  Senior  Executive's  resignation  or  termination  of  employment
(including  death),  any  option  held by that  Senior  Executive  is  generally
exercisable,  to the  extent  that it is  vested on the date of  resignation  or
termination,  for twelve  months after he or she ceases to be an employee of the
Company.  Notwithstanding  the foregoing,  (1) if any  non-employee  director or
Senior  Executive  is  terminated  or removed for  willful or gross  misconduct,
including,  without  limitation,  breach of fiduciary duty, then any outstanding
options granted to such optionee shall terminate  immediately  (unless otherwise
determined  by the  Committee),  and (2) if,  during the time period in which an
optionee's  options are exercisable after the optionee resigns or terminates his
or her employment with the Company,  the optionee  engages in deliberate  action
that, as determined by the Committee (whose  determination is final, binding and


                                      -26-
<PAGE>

conclusive),  causes  substantial  harm  to  the  interests  of the  Company  or
constitutes  a breach of any  obligation  of the optionee to the  Company,  then
those options shall terminate  immediately and automatically at the time of such
deliberate action.

      The options  granted  under the 1999 SESOP may not be  transferred  in any
manner other than by will or the laws of descent and distribution or pursuant to
a qualified domestic relations order as defined by the Code or Title I of ERISA.
During the optionee's lifetime, the option may be exercised only by the optionee
or his or her legal representative. If an optionee dies, an option generally may
be subsequently  exercised by the legal representatives of the optionee's estate
during the remaining term of the option, but only to the extent the optionee was
entitled to exercise such option as of the date of death.

      ADJUSTMENTS.  The number of shares of Common Stock covered by  outstanding
options,  the number of shares of Common Stock authorized for issuance under the
1999 SESOP,  the maximum  number of shares of Common Stock with respect to which
options  may be granted to any  employee  in any  calendar  year,  the number of
shares of Common Stock  automatically  granted to  non-employee  directors  each
year,   and  the  exercise  price  per  share  of   outstanding   options,   are
proportionately  adjusted  for any  increase or decrease in the number of issued
shares of Common Stock resulting from a stock split or stock dividend.  In event
of a  dissolution  or  liquidation  of the  Company,  outstanding  options  will
terminate upon  consummation of such transaction,  unless otherwise  provided by
the Committee.

      CHANGE OF CONTROL.  Options  granted under the 1999 SESOP to  non-employee
directors become immediately  exercisable in the event of a change of control of
the  Company.  For this  purpose,  a change of control  occurs if (1) any person
acquires  direct or indirect  ownership  of 50% of more of the  combined  voting
power of the then outstanding  voting securities of the Company as a result of a
tender or exchange offer, open market purchases,  privately negotiated purchases
or otherwise, (2) any election has occurred of persons to the Company's Board of
Directors that causes  two-thirds of the Company's Board of Directors to consist
of persons  other than (A) persons who were  directors of the Company on January
1, 1999 or (B) persons who were nominated for election to the Company's Board of
Directors  at a time when  two-thirds  of the Board of  Directors  consisted  of
persons who were directors of January 1, 1999, or (3) the Company's shareholders
approve (a) a statutory consolidation,  merger or amalgamation of the Company in
which the  Company  is not the  surviving  corporation  (other  than a merger or
amalgamation of the Corporation in which the holders of Common Stock immediately
prior to the merger or amalgamation have the same proportionate ownership of the
surviving corporation immediately after the merger or amalgamation),  or (b) any
sale,  lease,  exchange or other transfer of all, or  substantially  all, of the
Company's  assets  to an entity  that is not a wholly  owned  subsidiary  of the
Company.

      If any of the foregoing  change of control events  occurs,  a non-employee
director of the Company has the right,  for a period of sixty days following the
later of (1) the date of the event or (2) the  expiration of six months from the
date of  grant,  to  elect  to  surrender  his or her  unexercised  options  for
cancellation  and receive,  in the  discretion of the  Committee,  either a cash
payment or Common  Stock  equal to the  difference  between the  aggregate  fair
market  value of the  unexercised  shares  remaining  under the  option  and the
aggregate exercised price for such shares.

      In  addition,   if  a  transaction,   such  as  a  merger,   amalgamation,
reorganization,  consolidation, share exchange, transfer of assets, in which the
Corporation is not the surviving  corporation or pursuant to which a majority of
the shares of Company's  Common Stock are exchanged  for, or converted  into, or
otherwise become (A) securities of another  corporation or entity,  or (B) other


                                      -27-
<PAGE>

consideration,  the Committee  shall have the sole  discretion to determine that
(i) the  surviving,  continuing,  successor or purchasing  corporation  or other
entity,  as the case may be (the  "Acquiror"),  will either assume the Company's
rights and obligations under outstanding options granted under the 1999 SESOP or
substitute  options in  respect of the  Acquiror's  securities  for  outstanding
options  granted under the 1999 SESOP or (ii) the  outstanding  options shall be
canceled in exchange  for such  consideration  as the  Committee  shall  approve
(based on the value of the consideration  received in the transaction by holders
of the Company's Common Stock).

      AMENDMENTS  TO THE PLAN AND OPTIONS.  The  Committee  may amend,  suspend,
discontinue or terminate the 1999 SESOP in such respects as it deems  advisable,
but will not be able to amend the 1999 SESOP without shareholder  approval where
such  approval  is  required  in  order  to  comply  with  the  Canada  Business
Corporations  Act, the  Securities  Act  (Quebec),  the rules of the exchange on
which  the  Common  Stock is  listed,  Section  162(m)  of the Code or any other
requirement of applicable law or regulation.  Notwithstanding the foregoing, the
change-of-control  provisions  described  above that  relate to options  held by
non-employee  directors  may  not be  amended  or  terminated  at any  time.  In
addition,  the  Committee may waive any  conditions  or rights under,  or amend,
suspend,  discontinue  or terminate,  any option  granted to a Senior  Executive
and/or the terms of any corresponding option agreement. However, no amendment to
the 1999 SESOP or any option  granted  thereunder  shall,  without an optionee's
consent,  impair any of the rights of the optionee  under any option  previously
granted under the 1999 SESOP.

      EFFECTIVE  DATE OF THE PLAN.  The 1999 SESOP is subject to the approval by
the  affirmative  vote of a majority of the votes actually cast, in person or by
proxy, at the Meeting.  If the 1999 SESOP is approved,  it will become effective
as of January 25, 1999. The 1999 SESOP and any options  granted  thereunder will
terminate  and  become  null and void if the 1999 SESOP is not  approved  by the
shareholders  within  twelve  months  after  the  date  of its  adoption  by the
Company's Board of Directors.

SUMMARY OF U.S. AND CANADIAN FEDERAL INCOME TAX CONSEQUENCES

      U.S.  FEDERAL  INCOME TAX  CONSEQUENCES.  The  options  granted  and to be
granted under the 1999 SESOP will be treated as  non-qualified  stock options to
U.S.  taxpayers.  The grant of a  nonqualified  stock  option  has no  immediate
federal  income  tax  consequences  to the  optionee  or the  Company.  Upon the
exercise of a nonqualified stock option, the optionee recognizes ordinary income
(subject to wage  withholding  and  employment  taxes) in an amount equal to the
excess of the fair market  value of the shares on the date of exercise  over the
exercise price, and the Company is entitled to a corresponding  deduction if the
compensation  constitutes  an  ordinary  and  necessary  business  expense,  the
limitations of Section 162(m) of the Code do not apply, and applicable reporting
requirements  are  satisfied.  The  optionee's  tax  basis in the  shares is the
exercise  price plus the amount of ordinary  income  recognized  by the optionee
with respect to the option,  and the optionee's  holding period will commence on
the date the shares are  received.  Upon a  subsequent  sale of the shares,  any
difference  between  the  optionee's  tax  basis in the  shares  and the  amount
realized on the sale generally is treated as capital gain or loss.

      For capital  assets  (including  stock  received upon exercise of options)
held for more than 12 months,  the maximum  rate of tax on net capital  gains is
20%. A 10% rate applies to taxpayers in the 15% ordinary income tax bracket. For
holding periods  beginning after December 31, 2000, gains on capital assets held
for more than five years are  subject to a reduced  rate.  The 20% and 10% rates
discussed above are reduced to 18% and 8%, respectively.



                                      -28-
<PAGE>

      In  addition,   upon  the  occurrence  of  certain   "change  in  control"
transactions,  all outstanding options held by non-employee  directors under the
1999  SESOP  become  immediately   exercisable.   Under  certain  circumstances,
compensation  payments attributable to such options may be treated as "parachute
payments"  under  the Code,  in which  case a portion  of such  payments  may be
nondeductible  to the Company and the  recipient  may be subject to a 20% excise
tax.

      CANADIAN  FEDERAL INCOME TAX  CONSEQUENCES.  The following  summarizes the
principal Canadian federal income tax considerations  generally applicable under
the Income Tax Act  (Canada)  (the "ITA") and the  regulations  thereunder  (the
"Regulations")  to the grant and exercise of stock options under the 1999 SESOP.
The following  discussion is applicable only to an individual who is an employee
of the Company for purposes of the ITA and acquires stock options in respect of,
in the course of, or by virtue of such  employment  and who, for purposes of the
ITA,  is a resident of Canada,  deals at arm's  length with the Company and will
hold any Common Stock acquired pursuant to the stock option as capital property.
This summary is based on the provisions of the ITA and the  Regulations  and all
proposals  to  amend  the ITA  and the  Regulations  publicly  announced  by the
Department  of  Finance  prior  to the  date  hereof  and on the  administrative
practice  of  Revenue  Canada,  Customs,  Excise  and  Taxation.  Except for the
foregoing,  this summary does not take into account or anticipate any changes to
the ITA, the  Regulations or  administrative  practice  whether by  legislative,
governmental  or judicial  action.  This  summary does not take into account the
effect, if any, of the alternative minimum tax. For purposes of this summary all
amounts and values are assumed to be expressed in Canadian dollars.

      The grant of an option and the vesting of such option under the 1999 SESOP
will generally not give rise to any tax consequences to the participant.

      The amount (the "Benefit") by which the fair market value (at the date the
shares are acquired) of the shares  acquired  pursuant to the option exceeds the
option exercise price with respect to such shares will be included in the income
from  employment  of the  participant  for the  year in  which  the  shares  are
acquired. The ITA requires,  under certain circumstances,  the Company to deduct
and withhold amounts because of the payment of applicable income taxes, and this
may apply to the Benefit.

      Provided the option exercise price  (determined  without  reference to any
change in the value of U.S.  dollars  relative  to Canadian  dollars  during the
period  between  the grant of the option and the  exercise of the option) is not
less  than the  fair  market  value of the  shares  at the  date of  grant,  the
participant  should be entitled to deduct,  in computing his taxable  income for
the year, an amount equal to  one-fourth  of the Benefit  included in his income
for such year with respect to the exercise of such option.

      The  participant  will be entitled to add to the adjusted cost base of the
Common  Stock  acquired  upon the  exercise of the option an amount equal to the
Benefit in respect  thereof.  Upon a subsequent  disposition,  other than to the
Company,  of  the  Common  Stock  acquired  upon  exercise  of  an  option,  the
participant will generally realize a capital gain (or capital loss) equal to the
amount, if any, by which the proceeds of disposition exceed (or are exceeded by)
the aggregate of the adjusted cost base of such Common Stock to such participant
immediately prior to such disposition and any reasonable costs of disposition.

      The Company will not be entitled to any  deduction in computing its income
under the ITA as a result of the grant or exercise of a stock  option  under the
1999 SESOP.



                                      -29-
<PAGE>

      The foregoing  summary of the effect of Canadian and U.S.  federal  income
taxation upon the optionee and the Company under the 1999 SESOP does not purport
to be complete. In addition, this summary does not discuss the provisions of the
income  tax  laws of any  state,  province  or  foreign  country  in  which  the
participant  may reside.  Participants  should consult their own tax advisors to
determine the tax consequences to them of participating in the 1999 SESOP.

CURRENT PARTICIPATION UNDER THE 1999 SESOP

      As of January 25, 1999,  no options had been granted  under the 1999 SESOP
so all 650,000 reserved  thereunder  remained eligible for grant. Except for the
automatic grants to non-employee directors of the Company, it is not possible to
identify  the persons  who will be granted  options  under the 1999  SESOP,  the
number of shares  subject  to any  option,  or the terms and  conditions  of any
option, because these matters will be determined by the Committee in the future.
As of January 25, 1999 11  non-employee  directors are eligible to receive stock
options  under the 1999 SESOP and no  employee  of the  Company  qualified  as a
Senior Executive under the 1999 SESOP.

      THE BOARD OF  DIRECTORS  RECOMMENDS A VOTE FOR PROPOSAL 2 (APPROVAL OF THE
      COMPANY'S 1999  NON-EMPLOYEE  DIRECTOR AND SENIOR  EXECUTIVE  STOCK OPTION
      PLAN).


                     APPOINTMENT OF INDEPENDENT PUBLIC ACCOUNTANTS
                                   (PROPOSAL NO. 3)

      The Board of Directors has  recommended  that the  Company's  shareholders
appoint  Arthur  Andersen  LLP as the  independent  public  accountants  for the
Company to examine its  consolidated  financial  statements  for the year ending
December  31,  1999.  Arthur  Andersen  LLP  was  previously  appointed  by  the
shareholders as the independent public accountants for the Company for the years
ended December 31, 1989 through 1998. The Company's audited consolidated balance
sheets as of December 31, 1998 and 1997 and audited  consolidated  statements of
operations, shareholders' equity and cash flows for the years ended December 31,
1998, 1997 and 1996 have been submitted to the  shareholders as part of the 1998
Annual   Report  to   Shareholders   accompanying   this  Proxy   Statement.   A
representative of Arthur Andersen LLP will be present at the Meeting,  will have
the right to make a statement  if he or she so desires and will be  available to
respond to appropriate questions by the shareholders.

      THE BOARD OF DIRECTORS  RECOMMENDS A VOTE FOR PROPOSAL 3  (APPOINTMENT  OF
      ARTHUR ANDERSEN LLP AS INDEPENDENT PUBLIC ACCOUNTANTS).







                                      -30-
<PAGE>


                                    OTHER BUSINESS

      The  Company is not aware of any other  matters  that may come  before the
Meeting.  It is the intention of the persons named in the enclosed proxy to vote
the proxy in  accordance  with  their  best  judgment  if any other  matters  do
properly  come  before the  Meeting.  Whether  or not you attend the  Meeting in
person, please fill in, date and sign the enclosed proxy and return it promptly.
If you attend the Meeting,  you may, of course, vote your shares even though you
may have previously sent in your proxy.

                                  2000 ANNUAL MEETING

      In the event that  shareholders of the Company intend to make proposals to
be presented at the Company's 2000 Annual Meeting of  Shareholders to be held in
May 2000 (or such date as shall be designated by the Board of  Directors),  such
proposals, to be included in the 2000 Proxy Statement and form of proxy, must be
received  by the  Company at its  principal  executive  offices by no later than
December 31, 1999.


APPROVAL BY THE BOARD OF DIRECTORS

THE CONTENTS AND SENDING OF THIS PROXY STATEMENT HAVE BEEN APPROVED BY THE BOARD
OF DIRECTORS OF NORTH AMERICAN VACCINE, INC.



/s/ Daniel J. Abdun-Nabi
- ---------------------------------
Daniel J. Abdun-Nabi, Secretary



                                      -31-
<PAGE>


                                                                    EXHIBIT A

                          NORTH AMERICAN VACCINE, INC.
                         1999 NON-EMPLOYEE DIRECTOR AND
                       SENIOR EXECUTIVE STOCK OPTION PLAN

      This 1999  Non-Employee  Director and Senior  Executive  Stock Option Plan
(the  "Plan") of North  American  Vaccine,  Inc.,  a Canadian  corporation  (the
Corporation"),  is effective as of January 25, 1999.  The purpose of the Plan is
to help attract, keep and motivate the Corporation's  Non-Employee Directors and
Senior Executives, as those terms are defined in the Plan.

                                   ARTICLE I
                            STOCK SUBJECT TO OPTION
                            -----------------------

      The total  number  of shares  which  may be  issued  under  stock  options
("options")  granted pursuant to the Plan is 650,000 shares of the Corporation's
Common Stock, no par value per share ("Common  Stock").  The shares issued under
options shall be newly issued or treasury  shares of Common Stock.  The grant of
an option pursuant to the Plan shall reduce the number of shares of Common Stock
that  thereafter  may be available for future  grants under the Plan;  provided,
however,  that  if an  option  should  expire,  terminate  or  otherwise  become
unexercisable  for any  reason  without  having  been  exercised  in  full,  the
unpurchased  shares that were subject thereto shall,  unless the Plan shall have
been terminated,  become available for further grant under the Plan. Exercise of
an option in any manner  shall  result in a decrease  in the number of shares of
Common Stock that  thereafter  may be available for purchase under the option by
the number of shares of Common Stock as to which the option is exercised.

                                  ARTICLE II
                            ADMINISTRATION OF PLAN
                            ----------------------

      SECTION  2.1 The Plan shall be  administered  at all times by a  committee
appointed  by the  Corporation's  Board  of  Directors  (the  "Committee").  The
Committee  shall consist of not less than two members of the Board of Directors,
each of whom is a "non-employee  director" as defined in Rule 16b-3  promulgated
under the Securities  Exchange Act of 1934, as amended (the "1934 Act"),  and an
"outside  director"  as defined for  purposes of Section  162(m) of the Internal
Revenue Code of 1986, as amended (the "Code").

      SECTION  2.2  Subject to the  provisions  of the Plan,  the  Committee  is
authorized to interpret the Plan,  to  prescribe,  amend,  and rescind rules and
regulations relating to the Plan, and to make all other determinations necessary
or advisable for the administration of the Plan, including,  without limitation,
(i) to accelerate the vesting of any option already  granted,  (ii) to determine
whether  the  exercise  price of or taxes  relating  to an option may be paid in
already  owned  shares of Common  Stock  and/or  shares then  issuable  upon the
exercise of the option,  (iii) to  determine  the terms and  provisions  of each
option  granted under the Plan (which need not be  identical),  (iv) to waive or

<PAGE>

amend any and all restrictions and conditions of any options, including, without
limitation, extending the term of any option, and (v) to authorize any person to
execute on behalf of the Corporation  any instrument  required to effectuate the
grant of an option previously  granted by the Committee.  The Board of Directors
may in its  discretion at any time and from time to time alter the membership of
the Committee consistent with the requirements set forth in Section 2.1.

      SECTION 2.3 Any  interpretation  issued by the  Committee  shall be final,
conclusive and binding on each optionee.  No member of the Board of Directors or
the Committee shall be liable for any action or determination made in good faith
with respect to the Plan or any option agreement.

                                  ARTICLE III
             AUTOMATIC GRANT OF OPTIONS TO NON-EMPLOYEE DIRECTORS
             ----------------------------------------------------

      SECTION 3.1 Each member of the Board of Directors of the  Corporation  who
is  not  an  employee  of  the  Corporation  or  any  of  its   subsidiaries  (a
"Non-Employee  Director") shall automatically receive options in accordance with
the provisions of Section 3.2 below, without any further action or authorization
required by the Board of Directors or the Committee.

      SECTION 3.2 (a) On each  January 1,  commencing  on January 1, 2000,  each
Non-Employee  Director  who holds  office as of the  relevant  January  1, shall
automatically receive an option to acquire:

                  (i) 20,000  shares of the  Corporation's  Common  Stock if the
Non-Employee  Director  is the  Chairman  of the Board or  Vice-Chairman  of the
Board; or

                  (ii) 5,000  shares of the  Corporation's  Common Stock for all
other Non-Employee Directors.

            (b)  On  each  January  1,  commencing  on  January  1,  2000,  each
Non-Employee  Director  (other than the Chairman and Vice Chairman of the Board)
of the Corporation who holds office as of the relevant  January 1 and who serves
on a committee of the Board of  Directors  as of the  relevant  January 1, shall
automatically  receive  an  option,  in  addition  to the  grant of the  options
prescribed  in  Section  3.2(a)(ii),  above,  to  acquire  5,000  shares  of the
Corporation's Common Stock for each committee of the Board of Directors on which
he or she serves.

      SECTION 3.3 Each option automatically granted under this Article III shall
be exercisable in accordance with the following schedule:

            (a) each option shall first become exercisable to purchase one-third
of the shares  under such option on the first  January 1  following  the date of
grant of the option;


                                      -2-
<PAGE>

            (b) each  option  shall  first  become  exercisable  to  purchase an
additional  one-third  of the shares  under such option on the second  January 1
following the date of grant of the option; and

            (c) each  option  shall first  become  exercisable  to purchase  the
remaining  one-third  of the  shares  under such  option on the third  January 1
following the date of grant of the option.


                                  ARTICLE IV
                     GRANT OF OPTIONS TO SENIOR EXECUTIVES
                     -------------------------------------

      SECTION  4.1  Subject to the  provisions  of,  and  within the  parameters
established in, the Plan, the Committee shall have the exclusive power to select
the Senior Executives, as defined in Section 4.2, of the Corporation who will be
granted options, the time or times at which an option may be granted, the number
of shares for which an option is granted,  the vesting schedule for the options,
the term of the option,  and the  exercise  price per share of the options to be
granted;  provided,  however, that subject to the provisions of Article X of the
Plan, the maximum number of shares of Common Stock with respect to which options
may be granted  under the Plan to any Senior  Executive in any calendar  year is
one percent (1%) of the shares of Common Stock issued and  outstanding as of the
first day of such calendar year.

      SECTION 4.2 All Senior  Executives of the Corporation who are residents of
Canada  shall be eligible to receive  options to purchase  stock under the Plan.
The term  "Senior  Executive"  for  purposes  of the Plan  shall mean any person
exercising  the function of  president,  vice-president,  secretary,  treasurer,
controller or general  manager,  or similar  functions but shall not include any
person who is a director of the  Corporation,  whether or not such person  would
otherwise qualify as a Senior Executive. Senior Executives who are not residents
of Canada are not eligible to receive options to purchase Common Stock under the
Plan.

                                   ARTICLE V
                                 OPTION PRICE
                                 ------------

      For options  granted to Non-Employee  Directors,  the option price for the
purchase of any Common Stock  pursuant to any option  granted  under Article III
shall  be 100% of the fair  market  value  of the  Common  Stock at the time the
option is granted. For options granted to Senior Executives,  the minimum option
price for the purchase of any Common Stock  pursuant to any option granted under
Article IV shall be 100% of the fair  market  value of the  Common  Stock at the
time the option is granted. The fair market value thereof shall be determined by
the Committee;  provided,  however,  that where there is a public market for the
Common Stock, the fair market value per share shall be the closing sale price of
the Common Stock on the principal securities exchange (or Nasdaq, if applicable)
on which the Common  Stock is trading on the date of grant,  or if there were no
sales reported as of such date,  then the last date preceding such date on which
a sale was reported,  or if any such  exchange or quotation  system is closed on
that date, then on the last preceding date on which the securities  exchange (or
Nasdaq, if applicable) was open for trading.



                                      -3-
<PAGE>

                                  ARTICLE VI
                       TERM OF PLAN; VESTING OF OPTIONS
                       --------------------------------

      SECTION 6.1 The Plan shall be effective as of the date first above written
and shall expire on, and all options  authorized  under the Plan must be granted
on or before, January 25, 2009.

      SECTION  6.2 Each  option  granted  under  Article  III of the Plan  shall
provide that it is to be  exercised  within a period of ten (10) years after the
date the option is  granted  and shall be  exercisable  in  accordance  with the
vesting  schedule set forth in Section 3.3. Each option granted under Article IV
of the Plan shall  provide  that it is to be  exercisable  within a period to be
determined by the Compensation Committee,  which shall not exceed ten (10) years
after the date the option is granted,  and shall be  exercisable by the optionee
at such  time or times  as  shall be  prescribed  and  specified  in the  option
agreement  with  each  such  optionee.  Options  granted  under  the Plan may be
exercised  by the optionee in whole or in part or in  installments.  Options may
not be exercised for a fraction of a share.

      SECTION 6.3 (a) The  exercisability  of each option  granted under Article
III of the Plan  shall be  automatically  accelerated  so that each such  option
outstanding shall,  immediately prior to the specified  effective date of any of
the following events,  become fully exercisable with respect to the total number
of shares subject to such option and may be  exercisable  for all or any portion
of such shares, in the event that:

                        (i)  any  person  (as  defined  for  purposes of Section
13(d) and 14(d) of the 1934 Act, but  excluding the  Corporation  and any of its
wholly-owned  subsidiaries)  acquires  direct  or  indirect  ownership  of fifty
percent  (50%) or more of the  combined  voting  power  of the then  outstanding
voting  securities of the Corporation as a result of a tender or exchange offer,
open market purchases, privately negotiated purchases or otherwise;

                        (ii)  any  election has occurred of persons to the Board
of Directors of the  Corporation  that causes  two-thirds  of the  Corporation's
Board of Directors to consist of persons other than (A) persons who were members
of the  Corporation's  Board of Directors on January 1, 1999 and (B) persons who
were nominated by the  Corporation's  Board of Directors for election as members
of the  Corporation's  Board  of  Directors  at a time  when  two-thirds  of the
Corporation's  Board of  Directors  consisted of persons who were members of the
Corporation's Board of Directors on January 1, 1999; provided, however, that any
person  nominated for election by the Board of Directors of the  Corporation  at
least two-thirds of whom constituted persons described in clauses (A) and/or (B)
above or by persons who were themselves  nominated by such Board shall, for this
purpose,  be  deemed to have  been  nominated  by a Board  composed  of  persons
described in clause (A) above; or

                        (iii) the  shareholders of the  Corporation  approve (A)
any statutory consolidation,  merger or amalgamation of the Corporation in which
the  Corporation  is not the  surviving  corporation  (other  than a  merger  or
amalgamation of the Corporation in which the holders of Common Stock immediately
prior to the merger or amalgamation have the same proportionate ownership of the

                                      -4-
<PAGE>

surviving corporation immediately after the merger or amalgamation),  or (B) any
sale,  lease,  exchange or other  transfer  (in one  transaction  or a series of
related  transactions)  of all,  or  substantially  all,  of the  assets  of the
Corporation  to  an  entity  that  is  not  a  wholly-owned  subsidiary  of  the
Corporation.


      (b) If one of the events  cited in Section  6.3(a)  occurs,  any  optionee
granted  an option  pursuant  to Article  III of the Plan has the  right,  for a
period of sixty (60) days  following  the later of (i) the date of such event or
(ii) the  expiration of six (6) months from the date of grant of an option under
the Plan,  to elect to surrender for  cancellation  any option to the extent not
exercised and the optionee will be entitled to receive,  in the sole  discretion
of the Committee,  either a cash payment,  or Common Shares having a fair market
value,  equal to (A) the aggregate fair market value of the  unexercised  shares
remaining under the option surrendered for cancellation,  less (B) the aggregate
exercise price for such optioned shares;  provided,  however, if, in the opinion
of the Corporation's  counsel,  such discretion by the Committee would cause the
members of the Committee to cease to be  "non-employee  directors" as defined in
Rule 16b-3 of the 1934 Act or "outside  directors"  as defined  for  purposes of
Section  162(m) of the Code,  then such optionee shall receive only Common Stock
upon the surrender for cancellation of such option. For purposes of this Section
6.3(b),  fair market value shall be  determined  pursuant to Article V as of the
date on which an event  cited in  Section  6.3(a)  occurs.  Notwithstanding  the
foregoing,  an optionee  shall not be entitled to the  benefits of this  Section
6.3(b) where such event is solely attributable to the event described in Section
6.3(a)(i)  and the  optionee  is the  person  (or is a member  of a group  which
comprises the person) who acquires  beneficial  ownership of fifty percent (50%)
or more of the combined voting power of the then  outstanding  securities of the
Corporation.

                                  ARTICLE VII
                           TERMINATION OF EMPLOYMENT
                           -------------------------

      SECTION 7.1 (a) Except as noted in Section 7.2, upon a Senior  Executive's
resignation  from or  termination  of employment  with the  Corporation  for any
reason whatsoever  (including,  without  limitation,  death), any option held by
such person  shall be  exercisable  within  twelve (12) months after the date of
such  resignation  or  termination  (or such  shorter  or  longer  period as the
Committee  shall  determine)  to the extent such person was entitled to exercise
such option as of the date of such resignation or termination.

            (b) Except as noted in Section 7.2, upon a  Non-Employee  Director's
resignation or  termination  from the  Corporation's  Board of Directors for any
reason whatsoever  (including,  without  limitation,  death), any option held by
such person  shall be  exercisable,  to the extent  such person was  entitled to
exercise such option as of the date of such  resignation or termination,  at any
time prior to the expiration date of the option.

      SECTION 7.2  Notwithstanding  the provisions of Section 7.1, if any Senior
Executive or  Non-Employee  Director is terminated or removed by the Corporation
for  willful  or gross  misconduct,  including,  without  limitation,  breach of
fiduciary  duty (the  Committee's  determination  in this regard shall be final,
binding and conclusive), any and all options held by such person shall terminate
immediately and automatically at the time of his or her termination,  unless the
Committee  provides  for an earlier or later  time for the  termination  of such


                                      -5-
<PAGE>

option(s),  and  such  option(s)  will not be  exercisable  after  such  time of
termination unless otherwise determined by the Committee.

      SECTION 7.3 Subject to the  provisions of the Plan,  any option held by an
optionee at the time of his or her death may be  exercised  subsequently  by the
legal  representative of such optionee's estate during the remaining term of the
option,  but only to the extent such  optionee  was  entitled  to exercise  such
option  as of the  date  of his or her  death,  unless  the  Committee  provides
otherwise.  In the event of the death of an optionee  during the final three (3)
months of the time  period  specified  in  Section  7.1(a),  the  option  may be
exercised,  at any time within three (3) months following the date of his or her
death, by the optionee's estate or by a person or persons who acquired the right
to  exercise  the option by bequest or  inheritance,  but only to the extent the
optionee  was  entitled  to  exercise  such  option as of the date of his or her
death, unless the Committee provides for a longer or shorter period.

      SECTION 7.4 None of the events  described in this Article VII shall extend
the period of  exercisability  of an option beyond the  expiration  date thereof
prescribed  under  Section  6.2 above,  notwithstanding  the  intervention  of a
succeeding  vesting date or an event described in Section 6.3(a).  To the extent
that an  optionee  was not  entitled to exercise an option on the date of his or
her resignation or termination of employment with the Corporation for any reason
whatsoever  (including,  without  limitation,  death),  or if the  option is not
exercised within the time period specified in this Article VII, the option shall
terminate and become null and void, unless the Committee determines otherwise at
the time of or after the grant of the option.  Notwithstanding the provisions of
Sections 7.1 and 7.3 hereof,  no options shall be exercisable  after an optionee
resigns or terminates  his or her employment  with the  Corporation in the event
the optionee shall have,  during the time period in which his or her options are
exercisable,  engaged in deliberate action which, as determined by the Committee
in its  sole  discretion  (whose  determination  shall  be  final,  binding  and
conclusive),  causes  substantial  harm to the interests of the  Corporation  or
constitutes a breach of any  obligation of the optionee to the  Corporation.  In
such event,  the optionee shall forfeit all rights to any unexercised  option as
of the date of such  deliberate  action and all such  unexercised  options shall
terminate immediately and automatically at the time of such deliberate action.

      SECTION 7.5 The granting of an option to an optionee does not alter in any
way the Corporation's  existing rights to terminate such person's  employment or
position  with the  Corporation  at any time for any reason,  nor does it confer
upon such person any rights or privileges except as specifically provided for in
the Plan.



                                      -6-
<PAGE>

                                 ARTICLE VIII
                              NONTRANSFERABILITY
                              ------------------

      Options  granted under the Plan may not be sold,  assigned or transferred,
other than by will or by the laws of descent and  distribution  or pursuant to a
qualified  domestic  relations  order as  defined  in the Code or Title I of the
Employee  Retirement Income Security Act of 1974, as amended  ("ERISA"),  or the
rules  thereunder,  and, except with respect to a qualified  domestic  relations
order as aforesaid,  may be exercised during the lifetime of the optionee,  only
by such optionee or his or her legal representative.

                                  ARTICLE IX
                              METHOD OF EXERCISE
                              ------------------

      SECTION  9.1 During the period when an option is  exercisable,  the option
may be exercised,  in whole or in part, by giving  written notice of exercise to
the Corporation (in form acceptable to the Corporation) specifying the number of
shares of Common  Stock to be  purchased.  Such notice shall be  accompanied  by
payment in full of the aggregate exercise price of the shares to be purchased in
cash,  check  (including,  without  limitation,  payment  in  accordance  with a
cashless exercise program under which, if so instructed by the optionee,  Common
Stock may be issued directly to the optionee's  broker or dealer upon receipt of
the purchase  price in cash from the broker or dealer) or such other form and in
such other manner as the Committee may accept.  If and to the extent  determined
by the Committee in its sole discretion at or after grant, payment in full or in
part may also be made in the form of Common  Stock  duly  owned by the  optionee
(and for  which the  optionee  has good  title,  free and clear of any liens and
encumbrances)  or by reduction in the number of shares of Common Stock  issuable
upon such exercise  based,  in each case, on the fair market value of the Common
Stock on the date the option is exercised. In the event the purchase price of an
option  is paid in whole or in part  through  the  delivery  of shares of Common
Stock issuable in connection  with the exercise of the option,  an optionee will
be determined to have exercised the option with respect to those shares.  In the
event shares of Common Stock are surrendered to the  Corporation,  they shall be
canceled by the  Corporation.  Fair market  value of such Common  Stock shall be
determined as provided in Article V herein.

      SECTION 9.2 An option shall be deemed to be exercised  when written notice
of such exercise has been given to the  Corporation in accordance with the terms
of the option by the person entitled to exercise the option and full payment for
the shares with  respect to which the option is exercised  has been  received by
the  Corporation.  Until the issuance (as evidenced by the appropriate  entry on
the  books of the  Corporation  or of a duly  authorized  transfer  agent of the
Corporation)  of the share  certificate  evidencing the shares to be issued,  no
right to vote or receive  dividends or any other rights as a  shareholder  shall
exist with respect to the optioned shares,  notwithstanding  the exercise of the
option.  No adjustment  will be made for a dividend or other right for which the
record  date is prior to the date the share  certificate  is  issued,  except as
provided in the Plan.

      SECTION  9.3 As a condition  to the  exercise of any portion of an option,
the Corporation  may require the person  exercising such option to make whatever
provision is required,  in the reasonable opinion of the Corporation,  to ensure


                                      -7-
<PAGE>

that any  withholding or tax  obligations  required by United States or Canadian
federal, state/provincial,  or local law as a result of the granting or exercise
of such option are  withheld or paid in  accordance  with such  applicable  law.
Provisions  for addressing the  withholding or tax  obligations  pursuant to the
preceding sentence may include, but shall not be limited to, (i) full payment of
the  withholding  or  tax  obligations  by the  person  exercising  such  option
simultaneously with exercise of the option, (ii) the payment in shares of Common
Stock already owned by optionee,  based on the fair market value (as  determined
pursuant  to Article V) of such shares on the date that the  withholding  or tax
obligation is to be determined, to satisfy such withholding or tax requirements,
(iii) the withholding from the option,  at the appropriate  time, of a number of
shares  of  Common  Stock  sufficient,  based  upon the fair  market  value  (as
determined  pursuant  to  Article  V) of  such  shares  on  the  date  that  the
withholding or tax obligation is to be determined,  to satisfy such  withholding
or tax requirements,  and (iv) an agreement by the person exercising such option
that  such  withholding  or tax  obligations  may be  withheld  in full from any
compensation payable to such person.

      SECTION 9.4 (a) Shares shall not be issued  pursuant to the exercise of an
option  granted  under the Plan  unless  the  exercise  of such  option  and the
issuance  and  delivery of the shares  pursuant  thereto  shall  comply with all
relevant  provisions  of Canadian  and Unites  States laws,  including,  without
limitation,  Canada Business Corporations Act, the Securities Act (Quebec),  the
Securities  Act of 1933,  as amended,  the 1934 Act,  the rules and  regulations
promulgated  thereunder,  and the  requirements of any securities  exchange upon
which the shares may then be listed or Nasdaq,  and shall be further  subject to
the approval of counsel for the Corporation with respect to such compliance.  As
a condition to the exercise of an option, the Corporation may require the person
exercising such option to complete a  questionnaire  in a form acceptable to the
Corporation  and to make  certain  representations  and  warranties  required or
desirable (in the opinion of the Corporation or its counsel), including, without
limitation,  any  representations and warranties required by law, in the opinion
of counsel,  regarding  investment intent. If, in the opinion of counsel for the
Corporation,  such a  representation  is required  by any of the  aforementioned
relevant  provisions  of laws,  certificates  representing  shares  issued  upon
exercise of the option shall bear a legend  prohibiting  transfer of such shares
unless,  in the opinion of such counsel,  such transfer is not inconsistent with
any of the requirements of any applicable  Canadian and United States securities
laws.

            (b)  Inability  of the  Corporation  to  obtain  authority  from any
regulatory  body  having   jurisdiction,   which  authority  is  deemed  by  the
Corporation's  counsel to be  necessary  to the lawful  issuance and sale of any
shares  hereunder,  shall relieve the Corporation of any liability in respect of
the  failure to issue or sell such shares as to which such  requisite  authority
shall not have been obtained.

            (c) In the event  that any  option is  exercised  by the  executors,
administrators,  legatees or distributees of the estate of a deceased  optionee,
the Corporation  shall be under no obligation to issue stock  thereunder  unless
and until the Corporation is satisfied that the person or persons exercising the
option are the duly appointed legal  representatives of the deceased  optionee's
estate or the proper legatees or distributees thereof.



                                      -8-
<PAGE>

                                   ARTICLE X
               ADJUSTMENT OF NUMBER OF SHARES IN CERTAIN EVENTS
               ------------------------------------------------

      SECTION  10.1 Subject to any required  action by the  shareholders  of the
Corporation,  each of (i) the number of shares of Common  Stock  covered by each
outstanding  option,  (ii) the  number of shares of Common  Stock that have been
authorized  for issuance under the Plan but as to which no options have yet been
granted or that have been returned to the Plan upon cancellation, termination or
expiration of an option, (iii) the exercise price per share covered by each such
outstanding  option,  (iv) the  number of  shares  of Common  Stock set forth in
Section 3.2 and (v) the maximum  number of shares with respect to which  options
may  be  granted  to any  Senior  Executive  in  any  calendar  year,  shall  be
proportionately  adjusted  for any  increase or decrease in the number of issued
shares of Common  Stock  resulting  from a stock split or the payment of a stock
dividend  with respect to the Common Stock or any other  increase or decrease in
the  number  of issued  shares  of Common  Stock  effected  without  receipt  of
consideration  by the  Corporation;  provided,  however,  that conversion of any
convertible  securities  of the  Corporation  shall  not be  deemed to have been
"effected  without receipt of  consideration."  Such adjustment shall be made by
the Committee,  whose determination in that respect shall be final,  binding and
conclusive.  Except as expressly provided herein, no issuance by the Corporation
of shares of any class,  or  securities  convertible  into  shares of any class,
shall affect, and no adjustment by reason thereof shall be made with respect to,
the number or exercise price of shares of Common Stock subject to an option.

      SECTION  10.2  In  the  event  of a  dissolution  or  liquidation  of  the
Corporation,  all  outstanding  options will terminate upon the  consummation of
such action, unless otherwise provided by the Committee.

      SECTION  10.3 In the  event  of a  merger,  amalgamation,  reorganization,
consolidation,  share exchange,  transfer of assets or other transaction  having
similar effect  involving the  Corporation  in which the  Corporation is not the
surviving  corporation or pursuant to which a majority of the shares that are of
the same class as the shares that are  subject to  outstanding  options  granted
under the Plan are  exchanged  for,  or  converted  into,  or  otherwise  become
securities  of  another  corporation  or  entity,  or other  consideration,  the
Committee  shall have the sole  discretion to determine  that (i) the surviving,
continuing, successor or purchasing corporation or other entity, as the case may
be (the "Acquiror"), will either assume the Corporation's rights and obligations
under  outstanding  options  granted  under the Plan or  substitute  options  in
respect of the Acquiror's  securities for outstanding  options granted under the
Plan or (ii) the  outstanding  options  shall be canceled  in exchange  for such
consideration  as  the  Committee  shall  approve  (based  on the  value  of the
consideration received in the transaction by holders of the same class of shares
that are subject to outstanding options).

      SECTION 10.4 Adjustments and determinations  under this Article X shall be
made by the  Committee,  upon the advice of counsel,  whose  decisions  shall be
final, binding and conclusive.


                                      -9-
<PAGE>

                                  ARTICLE XI
                         AMENDMENT OF PLAN AND OPTIONS
                         -----------------------------

      SECTION 11.1 Subject to the provisions of Sections 11.3 and 11.4, the Plan
may be amended,  altered,  suspended,  discontinued or terminated at any time by
the Committee  without the approval of the  Corporation's  shareholders  in such
respects as the Committee may deem advisable so that the Plan and/or the options
granted  hereunder may conform to any changes in the law or in any other respect
which the  Committee  may deem to be in the best  interests of the  Corporation,
other than any  amendments  required to be approved  by  shareholders  under the
Canada Business  Corporation Act, the Securities Act (Quebec),  the rules of the
securities  exchange or Nasdaq on which the Common Stock is listed,  or in order
to  comply  with  Section  162(m)  of the  Code,  or any  other  requirement  of
applicable law or regulation.  No option may be granted during any suspension or
discontinuation  of the Plan or after its  termination.  Amendments  to the Plan
also  shall be  subject  to any  approvals  required  under  applicable  laws or
regulations  or under the  applicable  rules of any stock  exchange or Nasdaq on
which the Common Stock is listed.

      SECTION  11.2 Subject to the  provisions  of Sections  11.3 and 11.4,  the
Committee may waive any conditions or rights under,  or amend,  alter,  suspend,
discontinue  or terminate,  any option granted to a Senior  Executive  under the
Plan and/or any  corresponding  option  agreement;  provided,  however  that the
Committee  may amend any  option  and/or the terms of any  corresponding  option
agreement  only to the extent that the option and/or such option  agreement,  as
either may be amended,  could have been  granted  pursuant to the Plan with such
amended  terms.  No  amendment of an option shall be deemed to be the grant of a
new option for purposes of the Plan.

      SECTION 11.3 No amendment,  suspension,  discontinuation or termination of
the Plan or any option granted hereunder shall,  without an optionee's  consent,
impair any of the rights of the optionee under any option theretofore granted to
such  optionee  under the Plan.  The foregoing  shall not limit the  Committee's
rights to make determinations under Sections 7.2, 7.4 and 10.3 hereof.

      SECTION  11.4  Notwithstanding  the  provisions  of Section 11.1 and 11.2,
Section  6.3 shall not be  amended  or  terminated  at any  time.  Further,  any
amendment or termination of the Plan prior to a transaction described in Section
6.3  which:  (a) was at the  request  of a third  party  who  has  indicated  an
intention or taken steps reasonably  calculated to effect such  transaction;  or
(b) otherwise arose in connection  with or in anticipation of such  transaction,
shall be null and void and shall have no effect whatsoever.


                                  ARTICLE XII
                      RESERVATION AND ISSUANCE OF SHARES
                      ----------------------------------

      The  Corporation,  during the term of the Plan,  will at all times reserve
and keep  available  such number of shares as shall be sufficient to satisfy the
requirements  of the Plan and the options  granted  hereunder.  The  issuance of
shares  of Common  Stock  upon the  exercise  (in  accordance  with the Plan) of


                                      -10-
<PAGE>

options  granted  hereunder  as fully paid and  non-assessable  shares is hereby
authorized.

                                 ARTICLE XIII
                               OPTION AGREEMENT
                               ----------------

      Options  shall be evidenced by written  option  agreements  in the form or
forms approved by the Committee.

                                  ARTICLE XIV
                             SHAREHOLDER APPROVAL
                             --------------------

      The  effectiveness  of the  Plan  shall  be  subject  to  approval  by the
shareholders of the Corporation,  in a separate vote,  within twelve (12) months
after the date the Plan is adopted. Such shareholder approval shall be obtained,
at a duly held shareholders'  meeting,  by the affirmative vote of a majority of
the votes  actually  cast, in person or by proxy,  at such meeting on a separate
proposal to approve the Plan. All options granted prior to shareholder  approval
are granted conditional upon shareholder approval of the Plan.

                                  ARTICLE XV
                           MISCELLANEOUS PROVISIONS
                           ------------------------

      SECTION 15.1 NO RIGHTS AS A SHAREHOLDER.  An optionee shall have no rights
as a shareholder  with respect to any shares  covered by his or her option until
the date of the issuance of a share certificate to him or her for such shares.

      SECTION 15.2 NO RIGHT TO OPTION;  NO RIGHT TO  EMPLOYMENT.  No employee or
other person shall have any claim or right to be granted an option.  Neither the
Plan nor any action  taken  hereunder  shall be  construed  as giving any Senior
Executive  any right to be retained in the employ of the  Corporation  or any of
its subsidiaries.

      SECTION  15.3  INDEMNIFICATION.  In  addition  to  such  other  rights  of
indemnification  as they  may  have as  members  of the  Corporation's  Board of
Directors,  the members of the  Committee  shall be  indemnified,  to the extent
permitted by applicable  law, by the  Corporation  against,  and the Corporation
shall advance, the reasonable  expenses,  including attorneys' fees actually and
necessarily  incurred in  connection  with the  defense of any  action,  suit or
proceeding,  or in connection with any appeal  therein,  to which they or any of
them may be a party by reason of any action  taken or failure to act under or in
connection  with the Plan or any option  granted  thereunder,  and  against  all
amounts paid by them in settlement thereof (provided such settlement is approved
to the  extent  required  by  and in the  manner  provided  by the  Articles  of
Incorporation and By-laws of the  Corporation),  or paid by them in satisfaction
for a judgment in any such  action,  suit or  proceeding,  except in relation to
matters as to which it shall be adjudged in such action, suit or proceeding that
such Committee  member did not act honestly and in good faith with a view to the
best interests of the Corporation.  Within sixty (60) days after  institution of


                                      -11-
<PAGE>

any such  action,  suit or  proceeding,  a  Committee  member  shall  notify the
Corporation  of the  institution  of the suit and  grant to the  Corporation  in
writing  the  opportunity,  at its own  expense,  to handle and defend the same.
Failure  to  provide  such  notice  and  grant  shall,  at  the  option  of  the
Corporation,  relieve the  Corporation of the  indemnification  obligations  set
forth in this Section 15.3.

      SECTION  15.4  APPLICATION  OF  FUNDS.   The  proceeds   received  by  the
Corporation  from the sale of Common Stock  pursuant to options will be used for
general corporate purposes.

      SECTION 15.5 NO OBLIGATION TO EXERCISE  OPTION.  The granting of an option
shall impose no obligation upon the optionee to exercise such option.

      SECTION 15.6 OTHER COMPENSATION  PLANS. The adoption of the Plan shall not
affect any other share option or incentive or other compensation plans in effect
for the Corporation or any parent or subsidiary, nor shall the Plan preclude the
Corporation  or any parent or subsidiary  from  establishing  any other forms of
incentive or other  compensation  for employees and directors of the Corporation
or any parent or subsidiary.

      SECTION  15.7  OPTIONS  NOT  INCLUDABLE  FOR  BENEFIT   PURPOSES.   Income
recognized  by an optionee  pursuant to the  provisions of the Plan shall not be
included in the  determination  of benefits under any employee  pension  benefit
plan (as such term is defined in Section 3(2) of ERISA or the rules  thereunder)
or group  insurance or other benefit  plans  applicable to the optionee that are
maintained  by the  Corporation  or any of its  subsidiaries,  except  as may be
provided  under the  terms of such  plans or  determined  by  resolution  of the
Corporation's Board of Directors.

      SECTION 15.8 SINGULAR,  PLURAL, GENDER. Whenever used herein, nouns in the
singular shall include the plural,  and the masculine  pronoun shall include the
feminine gender.

      SECTION 15.9  HEADINGS,  ETC.,  NO PART OF PLAN.  Headings of Articles and
Sections hereof are inserted for  convenience and reference;  they constitute no
part of the Plan.

      SECTION 15.10 UNFUNDED PLAN. The Plan shall be unfunded.  The  Corporation
shall not be required to establish  any special or separate  fund or to make any
other  segregation  of assets to assure the issuance of shares or the payment of
monies  under the Plan and the  issuance  of shares and the payment of monies to
optionees under the Plan shall be subordinate to the claims of the Corporation's
general creditors.

      SECTION 15.11 ACCEPTANCE OF PLAN. By accepting any option or other benefit
under  the Plan,  each  optionee,  for  himself  and for his or her  successors,
assigns, heirs,  beneficiaries and personal and legal representatives,  shall be
conclusively deemed to have indicated his or her acceptance and ratification of,
and  consent  to,  any  action  taken  under  the Plan by the  Corporation,  the
Committee and the Corporation's Board of Directors.







                                      -12-
<PAGE>
      SECTION  15.12  GOVERNING  LAW. The Plan and all  determinations  made and
actions taken pursuant to the Plan shall be governed by the laws of the State of
Delaware,  except  that the  issuance  of  Shares  by the  Corporation  upon the
exercise of options shall be governed by the Canada Business Corporations Act.

      SECTION 15.13 NO STRICT CONSTRUCTION. No rule of strict construction shall
be implied against the  Corporation,  the Committee,  or any other person in the
interpretation  of any of the terms of the Plan,  any option  granted  under the
Plan or any rule or procedure established by the Committee.

      SECTION 15.14 SEVERABILITY.  Whenever possible, each provision in the Plan
and every option at any time granted under the Plan shall be interpreted in such
manner as to be effective and valid under  applicable  law, but if any provision
of the Plan or any option at any time granted under the Plan shall be held to be
prohibited by or invalid under  applicable law, then (a) such provision shall be
deemed  amended to  accomplish  the  objectives  of the  provision as originally
written to the fullest extent  permitted by law and (b) all other  provisions of
the Plan and every other option at any time granted  under the Plan shall remain
in full force and effect.


                                      -13-

<PAGE>


                          NORTH AMERICAN VACCINE, INC.
           PROXY FOR ANNUAL MEETING OF SHAREHOLDERS FEBRUARY 23, 1999

      The  undersigned  hereby names,  constitutes and appoints Randal Chase and
Neil Flanzraich,  or either of them acting in the absence of the other, with the
power of substitution,  the undersigned's  true and lawful attorney and proxy to
attend,  act and vote for and on behalf of the undersigned at the ANNUAL MEETING
OF  SHAREHOLDERS OF NORTH AMERICAN  VACCINE,  INC. (THE "COMPANY") TO BE HELD AT
275 ARMAND-FRAPPIER  BOULEVARD,  LAVAL, QUEBEC, CANADA ON TUESDAY,  FEBRUARY 23,
1999 COMMENCING AT 9:00 A.M. (LOCAL TIME), and at any adjournment  thereof,  and
to vote  all the  shares  of  common  stock  held of  record  in the name of the
undersigned in the manner  specified on the reverse side, with all of the powers
that the undersigned would possess if the undersigned were personally present.

      THE UNDERSIGNED  RESERVES THE RIGHT TO REVOKE THIS PROXY AT ANY TIME PRIOR
TO ITS  EXERCISE  BY (i) DULY  FILING A WRITTEN  NOTICE OF  REVOCATION  WITH THE
SECRETARY OF THE COMPANY,  (ii) DULY  EXECUTING AND DELIVERING A PROXY BEARING A
LATER DATE TO THE SECRETARY OF THE COMPANY, (iii) VOTING IN PERSON AT THE ANNUAL
MEETING OR (iv) IN ANY OTHER MANNER  PERMITTED BY LAW. FOR ANY WRITTEN NOTICE OF
REVOCATION OR  LATER-DATED  PROXY TO BE  EFFECTIVE,  IT MUST BE DELIVERED TO THE
COMPANY'S  REGISTERED  OFFICE AT ANY TIME UP TO AND  INCLUDING THE LAST BUSINESS
DAY PRECEDING THE DAY OF THE ANNUAL MEETING,  OR ANY ADJOURNMENT  THEREOF, OR TO
THE  CHAIRMAN  OF THE ANNUAL  MEETING ON THE DAY OF THE ANNUAL  MEETING,  OR ANY
ADJOURNMENT THEREOF. THE COMPANY'S REGISTERED OFFICE IS LOCATED AT 1 PLACE VILLE
MARIE, 40TH FLOOR, MONTREAL, QUEBEC H3B 4M4, CANADA.

      THE  UNDERSIGNED  MAY APPOINT A PROXYHOLDER,  OTHER THAN THE  PROXYHOLDERS
IDENTIFIED ABOVE, TO ATTEND AND ACT ON THE UNDERSIGNED'S  BEHALF AT THE MEETING.
TO DO SO,  STRIKE  THE NAME OF THE  PROXYHOLDERS  ABOVE  AND  SPECIFY  ABOVE THE
STRICKEN NAMES THE NAME(S) OF THE PERSON(S) SO APPOINTED.

      THIS PROXY IS BEING  SOLICITED  ON BEHALF OF  MANAGEMENT  OF THE  COMPANY.
UNLESS A CONTRARY  DIRECTION IS INDICATED IN THIS PROXY, THE SHARES  REPRESENTED
BY THIS PROXY WILL BE VOTED FOR: (1) ALL NOMINEES FOR DIRECTORS NAMED BELOW, (2)
APPROVAL OF THE COMPANY'S 1999 NON-EMPLOYEE  DIRECTOR AND SENIOR EXECUTIVE STOCK
OPTION PLAN AND (3)  APPOINTMENT OF ARTHUR  ANDERSEN LLP AS  INDEPENDENT  PUBLIC
ACCOUNTANTS OF THE COMPANY. IF SPECIFIC  INSTRUCTIONS ARE INDICATED,  THIS PROXY
WILL  BE  VOTED  IN  ACCORDANCE  WITH  SUCH  INSTRUCTIONS.  THIS  PROXY  CONFERS
DISCRETIONARY  AUTHORITY WITH RESPECT TO AMENDMENTS OR VARIATIONS TO THE MATTERS
IDENTIFIED  IN THE NOTICE  CALLING THE ANNUAL  MEETING OR OTHER MATTERS THAT MAY
PROPERLY COME BEFORE THE ANNUAL MEETING, AND ACCORDINGLY, IN THE EVENT THERE ARE
ANY SUCH  AMENDMENTS OR VARIATIONS  OR OTHER MATTERS  BROUGHT  BEFORE THE ANNUAL
MEETING OR ANY ADJOURNMENT OR POSTPONEMENT  THEREOF, THIS PROXY WILL BE VOTED IN
ACCORDANCE  WITH THE JUDGMENT OF THE  PROXYHOLDERS.  MANAGEMENT IS NOT PRESENTLY
AWARE OF ANY SUCH MATTERS TO BE PRESENTED FOR ACTION AT THE MEETING.

PLEASE VOTE, DATE AND SIGN THIS PROXY AND RETURN IT AT ONCE,  WHETHER OR NOT YOU
EXPECT TO ATTEND THE ANNUAL MEETING. YOU MAY VOTE IN PERSON IF YOU DO ATTEND THE
ANNUAL  MEETING.  IF THIS PROXY IS NOT DATED IN THE SPACE PROVIDED  BELOW, IT IS
DEEMED TO BEAR THE DATE ON WHICH IT IS MAILED TO SHAREHOLDERS.

                         (TO BE SIGNED ON REVERSE SIDE)

<PAGE>

        PLEASE MARK YOUR
 /X/    VOTES AS IN THIS
        EXAMPLE.

<TABLE>
<CAPTION>

                    FOR    WITHHOLD     NOMINEES:
<S>                 <C>    <C>          <C>                         <C>                                <C>       <C>         <C>

1. Election of      / /      / /        Neil W. Flanzraich           2. Approval of the Company's      FOR       AGAINST     ABSTAIN
   Directors.                           Francesco Bellini               1999 Non-Employee Director      / /        / /          / /
                                        Phillip Frost                   and Senior Executive Stock
                                        Alain Cousineau                 Option Plan.
                                        Jonathan Deitcher
FOR, except vote withheld from the      Denis Dionne                 3. Appointment of Independent      / /        / /          / /
following nominee(s):                   Gervais Dionne                  Accountants.           
                                        Lyle Kasprick
                                        Francois Legault             4. Upon such other  matters as may  properly  come
                                        Richard C. Pfenniger, Jr.       before,  or  incident  to the  conduct  of, the
                                        Randal D. Chase                 meeting  or any  adjournment  thereof  in  such
                                                                        manner as the proxyholders,  in their judgment,
                                                                        determine. Management is not presently aware of 
                                                                        any such matters to be presented  for action at
                                                                        the meeting.
                                                     
</TABLE>





SIGNATURE(S)                                         DATE
            -----------------------------------           ----------------------
NOTE: PLEASE SIGN EXACTLY AS NAME APPEARS HEREON. JOINT OWNERS SHOULD EACH SIGN.
      WHEN SIGNING AS ATTORNEY,  EXECUTOR,  ADMINISTRATOR,  TRUSTEE OR GUARDIAN,
      PLEASE GIVE FULL TITLE AS SUCH.






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