INSURED MUNICIPALS INC TR & INV QUAL TAX EX TR MULTI SER 110
497J, 1994-06-02
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                              June 2, 1994



Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C.  20549-1004

Attn:  Filing Desk - Stop 1-4

     Re:  Insured  Municipals  Income Trust and Investors'
          Quality  TaxExempt Trust, Multi-Series 110
          File No. 33-31635   CIK #856608

Ladies/Gentlemen:

     In  accordance  with the provisions of Rule 497(j) of
Regulation  C under  the  Securities  Act of 1933 (the
"Securities  Act")  this  letter serves to certify that the
most recent amendment to the Post-Effective of the  subject
Registration Statement on Form S-6 for the above  captioned
Trust  does not differ from that which would have been filed
pursuant  to Rule  497(b)  of  the  Securities Act.
Amendment  No.  5  to  the  PostEffective,  which was the
most recent amendment to the Post-Effective  of the
Registration Statement, was filed electronically with the
Commission on May 26, 1994.

                                    Very truly yours,




                                    Van Kampen Merritt Inc.



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