AMERICAN BIOGENETIC SCIENCES INC
424B3, 1996-10-17
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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PROSPECTUS

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                                 100,000 Shares

                       AMERICAN BIOGENETIC SCIENCES, INC.

                              Class A Common Stock

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           This  Prospectus  relates  to an  aggregate  of 100,000  shares  (the
"Shares") of Class A Common  Stock,  $.001 par value per share  ("Class A Common
Stock"),  of American  Biogenetic  Sciences,  Inc. (the "Company")  which may be
offered  and sold from  time to time,  by The Sage  Group,  Inc.  (the  "Selling
Stockholder")  upon the exercise of options  (collectively,  the  "Options")  to
purchase  up to 50,000,  25,000 and 25,000  shares of Common  Stock on or before
February 28, 2000, October 12, 2000 and December 13, 2000, respectively, each at
an exercise price of $2.25 per share. See "Selling Stockholder."

           The Shares may be offered  for sale by the Selling  Stockholder  from
time  to  time  in  the   over-the-counter   market,  in  privately   negotiated
transactions or otherwise,  at market prices  prevailing at the time of sale, at
prices related to such  prevailing  market prices or at negotiated  prices.  The
Shares may be sold  directly by the Selling  Stockholder  or through one or more
broker-dealers.  Such  broker-dealers  may receive  compensation  in the form of
commissions,  discounts  or  concessions  from the  Selling  Stockholder  and/or
purchasers of Shares for whom such  broker-dealers  may act as agent, or to whom
they may sell as  principal,  or both  (which  compensation  as to a  particular
broker-dealer  may  be  in  excess  of  customary   commissions).   The  Selling
Stockholder and such  broker-dealers  may be deemed to be "underwriters"  within
the meaning of the  Securities Act of 1933, as amended (the  "Securities  Act"),
and any discounts,  commissions and concessions and any profits  realized on any
sale of the Shares may be deemed to be underwriting  compensation.  See "Selling
Stockholder" and "Plan of Distribution".

           The Company will not receive any of the proceeds from the sale of the
Shares by the Selling  Stockholder.  However,  the Company will receive proceeds
from the exercise of the  Options,  if  exercised.  See "Use of  Proceeds".  The
Company will bear all expenses in connection with the filing of the Registration
Statement  of which  this  Prospectus  forms a part,  except  that  the  Selling
Stockholder will pay all discounts and commissions payable to broker-dealers and
the fees and expenses, if any, of its counsel.

           AN INVESTMENT IN THE SHARES OFFERED HEREBY  INVOLVES A HIGH DEGREE OF
RISK. SEE "RISK FACTORS" BEGINNING ON PAGE 3 FOR A DISCUSSION OF CERTAIN FACTORS
THAT SHOULD BE CONSIDERED BY PROSPECTIVE INVESTORS.

           The  Class A Common  Stock is  quoted on The  Nasdaq  Stock  Market's
National  Market System  ("Nasdaq/NMS")  under the symbol MABXA.  On October 15,
1996, the closing price of the Class A Common Stock on Nasdaq/NMS was $5.875 per
share.

                                ----------------

    THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES
       AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION NOR HAS
         THE SECURITIES AND EXCHANGE COMMISSION OR ANY STATE SECURITIES
             COMMISSION PASSED UPON THE ACCURACY OR ADEQUACY OF THIS
                      PROSPECTUS. ANY REPRESENTATION TO THE
                         CONTRARY IS A CRIMINAL OFFENSE.

                                ----------------

                 The date of this Prospectus is October 16, 1996
<PAGE>



                              AVAILABLE INFORMATION

           The  Company  is  subject to the  informational  requirements  of the
Securities  Exchange  Act of 1934,  as amended  (the  "Exchange  Act"),  and, in
accordance therewith, files reports, proxy statements and other information with
the Securities and Exchange Commission (the "Commission").  Such reports,  proxy
statements  and other  information  filed by the  Company can be  inspected  and
copied at the public reference  facilities  maintained by the Commission at Room
1024,  Judiciary Plaza, 450 Fifth Street, N.W.,  Washington,  D.C. 20549, and at
the Commission's  Regional Offices located at 7 World Trade Center,  13th Floor,
New York, New York 10048 and Citicorp  Center,  500 West Madison  Street,  Suite
1400, Chicago, Illinois 60661-2511. Copies of such material can also be obtained
at  prescribed  rates  from the  Public  Reference  Section  of the  Commission,
Judiciary Plaza, 450 Fifth Street, N.W., Washington,  D.C. 20549. The Commission
maintains a Web site  (http://  www.sec.gov)  that contains  reports,  proxy and
information  statements and other information  electronically  filed through the
Commission's Electronic Data Gathering, Analysis and Retrieval system ("EDGAR").
The Common Stock is currently quoted on The Nasdaq Stock Market and such reports
and other information can also be inspected at the offices of Nasdaq Operations,
1735 K Street, N.W., Washington, D.C. 20006.

           The Company has filed with the Commission,  Washington, D.C. 20549, a
Registration  Statement (No. 333-13615) under the Securities Act with respect to
the Shares (the  "Registration  Statement").  As  permitted  by the rules of the
Commission, this Prospectus does not contain all of the information set forth in
the Registration  Statement and the exhibits and schedules thereto.  For further
information with respect to the Company and the Shares offered hereby, reference
is made to the  Registration  Statement  and the  exhibits and  schedules  filed
therewith.  Statements  contained  in  this  Prospectus,  and  in  any  document
incorporated  herein by  reference,  as to the  contents of any  contract or any
other document  referred to are not necessarily  complete and, in each instance,
reference  is made to the copy of such  contract or other  document  filed as an
exhibit to the  Registration  Statement or such  document,  each such  statement
being  qualified in all respects by such reference.  A copy of the  Registration
Statement may be inspected without charge at the Commission's  principal office,
Room 1024, Judiciary Plaza, 450 Fifth Street, N.W., Washington,  D.C. 20549, and
copies of all or any part of the  Registration  Statement  may be obtained  from
such office  upon the  payment of the fees  prescribed  by the  Commission.  The
Registration  Statement has been filed  through EDGAR and is publicly  available
through the Commission's Web site (http://www.sec.gov).


                      INFORMATION INCORPORATED BY REFERENCE

           The  following  documents  heretofore  filed by the Company  with the
Commission (File No. 0-19041)  pursuant to Section 13(a) of the Exchange Act are
incorporated  herein by reference:  (i) the Company's Annual Report on Form 10-K
for the year ended December 31, 1995,  (ii) the Company's  Quarterly  Reports on
Form 10-Q for the  quarters  ended March 31, 1996 and June 30,  1996,  (iii) the
Company's  Current  Report on Form 8-K dated (date of earliest  event  reported)
September  30, 1996 and (iv) the  description  of the  Company's  Class A Common
Stock contained in the  Registration  Statement on Form 8-A filed by the Company
on February 26, 1991, including any amendment or report filed for the purpose of
updating  such  description.  Each  document  filed by the  Company  pursuant to
Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act subsequent to the date of
this Prospectus but prior to the termination of this offering shall be deemed to
be incorporated by reference into this Prospectus and to be part hereof from the
date of the filing of such document.  Any statement contained in this Prospectus
or in a document  incorporated or deemed to be incorporated by reference  herein
shall be deemed to be modified or superseded for purposes of this  Prospectus to
the extent that a statement  contained herein or in any other subsequently filed
document  which  also is or is deemed to be  incorporated  by  reference  herein
modifies or supersedes such  statement.  Any statement so modified or superseded
shall not be deemed,  except as so modified or superseded,  to constitute a part
of this Prospectus.

           THE COMPANY WILL PROVIDE,  WITHOUT  CHARGE TO EACH PERSON  (INCLUDING
ANY BENEFICIAL  OWNER) TO WHOM A COPY OF THIS PROSPECTUS IS DELIVERED,  UPON THE
WRITTEN OR ORAL REQUEST OF ANY SUCH PERSON, A COPY OF ANY DOCUMENT  INCORPORATED
BY REFERENCE IN THIS  PROSPECTUS  (OTHER THAN EXHIBITS  UNLESS SUCH EXHIBITS ARE
EXPRESSLY  INCORPORATED  BY REFERENCE  IN SUCH  DOCUMENTS).  REQUESTS  SHOULD BE
DIRECTED TO AMERICAN BIOGENETIC SCIENCES, INC., 1375 AKRON STREET, COPIAGUE, NEW
YORK 11726 (516) 789-2600, ATTENTION: JOSEF C. SCHOELL, VICE PRESIDENT, FINANCE.


                                       -2-

<PAGE>


                                   THE COMPANY

           American  Biogenetic  Sciences,  Inc. is engaged in the  research and
development  of   cardiovascular   and  neurobiology   products  for  commercial
development.  The Company's enabling technology is a patented antigen-free mouse
colony which allows the generation of highly specific monoclonal antibodies that
are difficult to obtain from conventional systems. The Company has utilized this
technology  to  supply  antibodies  for  its  innovative  in  vitro  and in vivo
diagnostic products.

           Over the  last  few  years  the  Company  has  directed  its  efforts
primarily toward the development of  cardiovascular  and neurobiology  products,
which has led to the  development of the Company's  Thrombus  Precursor  Protein
(TpP(TM)) test, an assay for the detection of active  thrombosis  (blood clots),
and Functional Intact  Fibrinogen  (FiF(TM)) test, an assay to measure levels of
fibrinogen  in blood,  as well as the  Company's  patented  specific  monoclonal
antibody MH1, with radioisotope, for use as an in vivo imaging agent.

           The Company was  incorporated  in Delaware on September 1, 1983.  The
Company's  principal  executive  offices  are  located  at  1375  Akron  Street,
Copiague,  New York 11726,  and its  telephone  number at that  address is (516)
789-2600.


                                  RISK FACTORS

           An investment in the  securities  offered  hereby is  speculative  in
nature,  involves a high  degree of risk and should not be made by any  investor
who cannot afford the loss of his entire investment. In evaluating an investment
in the Company,  prospective  investors should carefully  consider the following
risk  factors in addition to the other  information  included  herein and in the
information  incorporated and deemed to be incorporated herein by reference (see
"Information Incorporated by Reference",  above). Certain statements included in
this Prospectus (and the information  incorporated and deemed to be incorporated
herein  by  reference)   concerning  the  Company's   future   results,   future
performance,  intentions, objectives, plans and expectations are forward-looking
statements.  Those statements are subject to a number of known and unknown risks
and uncertainties that, in addition to general economic and business conditions,
could cause actual results,  performance  and  achievement to differ  materially
from those described or implied in the forward-looking statements.  Factors that
could cause or contribute to such differences  include,  but are not limited to,
those discussed below.

           DEVELOPMENT STAGE COMPANY;  HISTORY OF LOSSES;  ACCUMULATED  DEFICIT.
The  Company  commenced  operations  more than ten years ago and  remains in the
development  stage as it has not yet generated any revenues from product  sales,
although the Company has received an aggregate of $1,265,000  in licensing  fees
under collaborative  agreements since inception.  While the Company has products
at  various  stages of  development,  there can be no  assurance  as to when the
Company  may begin  generating  revenues  from  product  sales and cease being a
development  stage  company.  The  development  of the  Company's  products  has
required,  and is expected to continue  to  require,  significant  research  and
development,  preclinical  testing and clinical  trials,  as well as  regulatory
approvals.   These   activities,   together  with  the  Company's   general  and
administrative expenses, have resulted in significant losses and are expected to
continue to result in significant losses for the foreseeable future. At June 30,
1996,  the Company had an  accumulated  deficit of  $37,712,000.  The  Company's
ability  to achieve  profitability  is  dependent,  in part,  on its  ability to
successfully  complete its existing  products  and products  under  development,
obtain  required  regulatory  approvals and manufacture and market such products
directly or through  partners.  Due to the time before the Company expects to be
able to manufacture and commercially  market its existing and under  development
products,  the Company  expects to incur  operating  losses for the  foreseeable
future.  The Company's  operations are subject to numerous risks associated with
the  development  of  pharmaceutical  products,  including the  competitive  and
regulatory  environment in which the Company operates. In addition,  the Company
may encounter  unanticipated  problems,  including  development,  manufacturing,
distribution  and  marketing  difficulties,  some of  which  may be  beyond  the
Company's financial and technical abilities to resolve.  Accordingly,  there can
be no assurance  that the  Company's  existing,  under  development  or proposed
products  will  prove  to be  commercially  viable,  or that  the  Company  will
successfully market any products or achieve  significant  revenues or profitable
operations.

           NEED FOR  ADDITIONAL  FINANCING.  At June 30,  1996,  the Company had
working  capital  of  $8,099,000  ($16,700,000  adjusted  to give  effect to the
estimated net proceeds received by the Company from the sale, on

                                       -3-

<PAGE>



September  30,  1996,  of  an  aggregate   $9,000,000  principal  amount  of  7%
Convertible   Debentures  due  September  30,  1998).   However,  the  research,
development,  commercialization,  manufacturing  and  marketing of the Company's
existing, under development and proposed products is likely to require financial
resources  significantly in excess of those presently  available to the Company.
Accordingly,  the Company intends to seek additional financing (which may result
in  borrowings  that could affect its results of  operations  or the issuance of
additional  shares of the  Company's  capital  stock  and/or  rights to  acquire
additional  shares of capital stock that could cause a dilution of the interests
of then existing stockholders in the Company).  The Company also intends to seek
collaborative,   licensing,   co-marketing  or  other  arrangements  with  large
pharmaceutical  companies or other third parties to provide  additional  funding
and  clinical   expertise  to  perform  tests  necessary  to  obtain  regulatory
approvals,  provide  manufacturing  expertise and market the Company's products,
which may result in the Company  sharing the benefits of its products  with such
third parties as well as sharing with, or relying upon, the management of others
for the development, testing and/or marketing of its products.

           There can be no  assurance  that the Company  will be able to arrange
financing,  collaborative  arrangements  or other  third party  arrangements  on
acceptable  terms  necessary  to  fully  develop  and  commercialize  any of its
products. If the Company is unable to enter into such arrangements or obtain the
substantial  financing  necessary  on  acceptable  terms,  it would be unable to
complete development of or commercialize its products.

           UNPROVEN PRODUCTS. The Company's existing products and products under
development are in the developmental stage and are subject to the risks inherent
in the development of products based upon biotechnology.  These products require
further  research,  development,  testing and regulatory  clearance.  All of the
Company's products will require  demonstration of commercial scale manufacturing
before any can be proven to be  commercially  viable.  The  Company is unable to
predict with any degree of certainty  when,  or if, the  research,  development,
testing  and  regulatory  approval  process  for  any of its  products  will  be
completed.  There can be no assurance that the Company's  technology will result
in any product  meeting  applicable  regulatory  standards,  be capable of being
produced in  commercial  quantities at  reasonable  costs,  be acceptable to the
medical  community,  or be successfully  marketed.  Accordingly,  the Company is
unable to predict whether its technology will result in any commercially  viable
product.

           CERTAIN  EFFECTS  OF  GOVERNMENT   REGULATION.   The   investigation,
manufacture,  exportation  and sale of diagnostic and  therapeutic  products and
vaccines in or from the United  States is subject to  regulation by the Food and
Drug  Administration  (the  "FDA"),  including  review  and/or  approval  before
marketing,  as well as by comparable  foreign and state agencies.  Some in vitro
diagnostic  products  are  eligible for an  accelerated  application  process in
accordance  with Section  510(k) of the 1976 Medical  Device  Amendments  to the
Federal Food, Drug and Cosmetic Act as a product  "substantially  equivalent" to
another  product in commercial  distribution in the United States before May 28,
1976.  The  Company  has filed for  Section  510(k)  regulatory  review  for its
microtiter  plate format in vitro TpP  diagnostic  test and intends to seek such
clearance as to a microtiter  plate format of its FiF diagnostic test. There can
be no assurance that such products,  or other in vitro  diagnostic test products
that the Company  may  develop,  will be  eligible to use the 510(k)  procedure.
Therefore,  the Company may be required  to utilize  other  regulatory  approval
processes  which may result in higher costs and require more  extensive  time in
bringing  products to market.  The Company is proceeding with the development of
its in vitro products through use of its resources and through arrangements with
contractors  and  consultants.  The cost of  obtaining  FDA approval for in vivo
products  (such as is required for the Company's  patented  specific  monoclonal
antibody MH1 obtained from the Company's  antigen free mouse colony) is far more
expensive  and time  consuming  than the  costs  associated  with the  review of
products for in vitro use. Therefore, the Company intends to seek joint ventures
or licensing  arrangements  with respect to its existing MH1 imaging product and
other  proposed  in vivo  products  under  which the costs  associated  with the
regulatory  review and/or approval process will be borne by, or shared with, the
joint  venturer or licensee.  There can be no assurance that the Company will be
able to enter  into any  such  arrangements  nor,  if it is able to,  the  terms
thereof.  Also, there can be no assurance that regulatory review and/or approval
will be obtained for its TpP, FiF and MH1 imaging products or for any additional
products the Company may develop.  Even if regulatory  review and/or approval is
obtained  initially,  a marketed product is subject to continual FDA review, and
the discovery of previously  unknown  problems may result in  restrictions  on a
product's marketing or the withdrawal of approval to market the product.

           DEPENDENCE ON ACCEPTANCE BY MEDICAL COMMUNITY.  Sales on a commercial
basis of the Company's  products for use as diagnostics or therapeutics  will be
substantially  dependent  on  acceptance  by the medical  community.  Widespread
acceptance of the  Company's in vitro  diagnostic  tests as a useful  adjunct to
diagnosis

                                       -4-

<PAGE>



and treatment  will require  educating the medical  community as to the benefits
and reliability of such products. Similarly, the use of any products for in vivo
diagnosis  (including those utilizing mouse antibodies) and therapy will require
educating the medical  community as to their benefits,  reliability,  safety and
effectiveness. There can be no assurance that any of the Company's products will
be  accepted  in the  medical  community,  and the Company is unable to estimate
whether it will be able to, and if so the length of time it would take to,  gain
such acceptance.

           MARKETING ARRANGEMENTS OR SALES PERSONNEL.  During the fourth quarter
of 1995, the Company entered into a license and  collaboration  agreement with a
large  pharmaceutical  company to co-develop  and market the Company's TpP assay
and to market  its TpP test in latex  based  particle  agglutination  format and
entered  into  another  license  agreement  with a second  large  pharmaceutical
company for marketing  another format of the TpP assay.  The Company  intends to
seek arrangements with other large pharmaceutical companies to market these, its
FiF, under development and proposed in vitro products.  In the event the Company
is unable to enter into other  arrangements or if the arrangements  which it has
entered  into or may enter into in the future are not  successful,  the  Company
would likely seek to market such products through independent distributors which
would require the Company to develop a marketing  program to support  sales.  In
such event,  the Company  would be  required,  among  other  things,  to pay the
expenses  of  developing   promotional   literature  and  aides,   hiring  sales
representatives  and completing studies to interest  distributors in selling the
Company's in vitro  diagnostic  tests.  Any  independent  distributors  that the
Company may use would in all likelihood also market competitive products.  There
can be no assurance that the Company will be able to enter into arrangements for
the  distribution  of any in vitro products on satisfactory  terms.  Any in vivo
products  will  require  the  marketing  and  sales   organization  of  a  large
pharmaceutical  company to establish them in the  marketplace.  In the event the
Company were unable to enter into satisfactory marketing arrangements,  it would
be unable to commercially market any in vivo products.

           MANUFACTURING FACILITIES.  While the Company is presently producing a
limited  quantity of monoclonal  antibodies for testing and evaluation of its in
vitro  products,  there can be no  assurances  that the Company  will be able to
either  finance  or meet  FDA  regulations  for  good  manufacturing  procedures
required in order to convert and operate such facility for commercial production
of such products. The Company does not intend to establish its own manufacturing
operations  for its in  vivo  products  unless  and  until,  in the  opinion  of
management of the Company,  the size and scope of its business and its financial
resources so warrant.  The Company has entered  into an agreement  under which a
third  party is to  manufacture  the  Company's  in vivo  diagnostic  monoclonal
antibody  for use in clinical  testing.  It is the  Company's  intention to seek
additional third parties to manufacture its in vivo monoclonal antibody or enter
into a joint venture or license agreement with a partner who will be responsible
for future  manufacturing.  Each joint venture partner or contract  manufacturer
participating in the manufacturing  process of the Company's monoclonal antibody
must comply with FDA regulations and file  documentation with the FDA to support
that part of the  manufacturing  process  in which it is  involved.  There is no
assurance that third parties will be able to manufacture  sufficient  quantities
of the  Company's  in vivo  monoclonal  antibody  necessary  to obtain  full FDA
clearance, that the FDA will accept the Company's manufacturing arrangements, or
that these commercial  manufacturing  arrangements can be obtained on acceptable
terms.

           PATENTS AND  PROTECTION  OF  PROPRIETARY  INFORMATION.  The Company's
policy is to seek patent protection for its products and products resulting from
any  development  and licensing  arrangements  into which the Company may enter.
Such patents generally  require one to five years before issuance.  There can be
no  assurance  that any  pending  or future  patent  applications  will issue as
patents. If patents do not issue from present or future patent applications, the
Company may be subject to greater competition.  Moreover, other technology which
does not infringe upon the Company's technology could be independently developed
by others who would then be free to use the technology in  competition  with the
Company.  Also,  there can be no  assurance  that any of the  patents  which the
Company  has  obtained  or which may be issued in the future  will  provide  the
Company with significant competitive advantages,  or that challenges will not be
instituted  against the  validity or  enforceability  of any such patents or, if
instituted,  that such challenges will not be successful. The cost of litigation
to uphold the validity of a patent and prevent  infringement  can be substantial
even if the Company were to prevail. Furthermore, there can be no assurance that
others  have  not  independently   developed,  or  will  not  develop,   similar
technologies  and  products  or  will  not  develop   distinctively   patentable
technology  duplicating  the Company's  technology or design around the patented
aspect of the Company's  technologies  and products or that the Company will not
infringe  patents or other rights owned by others,  licenses to which may not be
available to the Company or, if available,  may not be available on commercially
reasonable terms.


                                       -5-

<PAGE>



           In  certain  cases,  the  Company  may  rely  on  trade  secrets  and
contractual confidentiality agreements with consultants, employees and others to
protect any proprietary  technology that it develops.  There can be no assurance
that trade  secrets  will be  developed,  or that  secrecy  obligations  will be
honored,  or that  others  will not  independently  develop  similar or superior
technology.  The  Company's  scientific  advisors  may be  employed  by or  have
agreements with third parties and any inventions  discovered by such individuals
may not necessarily become the property of the Company.

           COMPETITION;  RAPID TECHNOLOGICAL CHANGES. Many companies,  including
large  pharmaceutical,   chemical,   biotechnology  and  agricultural  concerns,
universities  and other  research  institutions,  with  financial  resources and
research and development staffs and facilities  substantially greater than those
of the  Company,  as well  as a  number  of  small  companies,  are  engaged  in
researching  and  developing  products  which  are  or  may be  similar  to,  or
competitive  with,  the  Company's  existing,  under  development  and  proposed
products.

           Other  products  now in  use,  presently  undergoing  the  regulatory
approval  process,  or under development by others may perform similar functions
as the Company's existing, under development and proposed products. The industry
is characterized by rapid  technological  advances,  and competitors may develop
products which may render the Company's existing, under development and proposed
products obsolete or which have advantages over the Company's products,  such as
greater accuracy and precision or greater  acceptance by the medical  community.
In addition, competitors may be able to complete the regulatory approval process
sooner and, therefore, market their products earlier than the Company.

           RETENTION AND ATTRACTION OF KEY PERSONNEL. The success of the Company
may be  dependent  on the efforts of Alfred J.  Roach,  Chairman of the Board of
Directors and a major stockholder of the Company, Dr. Paul E. Gargan, President,
Chief Scientific Officer and a Director of the Company, and P. Scott Waterhouse,
Executive Vice President and Chief  Operating  Officer of the Company.  Only Dr.
Gargan is a party to an employment  agreement with the Company.  The loss of the
services of Mr. Roach,  Dr. Gargan or Mr.  Waterhouse,  as well as certain other
personnel, could adversely affect the Company's business and prospects.

           Because  of the  nature of its  business,  the  Company's  success is
dependent  upon its  ability to attract  and  retain  technologically  qualified
personnel,  particularly research scientists.  There is substantial  competition
for qualified personnel, including competition from companies with substantially
greater resources than the Company.  There is no assurance that the Company will
be successful in recruiting or retaining  personnel of the requisite  caliber or
in  adequate  numbers to enable it to conduct its  business,  and it may be time
consuming and costly to recruit qualified personnel.

           The Company's scientific advisors are employed by or work for others,
and they are  expected  to  devote  only a small  portion  of their  time to the
Company.  In addition,  these  individuals have employment,  consulting or other
advisory arrangements with other entities and, as a result, their obligations to
these other  entities  may  conflict or compete  with their  obligations  to the
Company.

           PRODUCT  LIABILITY;  ABSENCE  OF  INSURANCE  COVERAGE.  The  testing,
marketing  and  sale  of  pharmaceutical  products  entails  a risk  of  product
liability claims by consumers and others. Additionally, the Company's monoclonal
antibodies  are generated from an antigen free mouse colony and instances of the
human immune system  negatively  reacting to mouse derived  antibodies have been
reported by others.  Product  liability  claims may be  asserted by  physicians,
laboratories,  hospitals or patients  relying upon the results of the  Company's
diagnostic  tests.  Claims may also be asserted against the Company by end users
of the Company's products, including persons who may be treated with any in vivo
diagnostic or therapeutics.

           Certain  distributors  of  pharmaceutical  products  require  minimum
product liability  insurance coverage as a condition  precedent to purchasing or
accepting   products  for  distribution.   Failure  to  satisfy  such  insurance
requirements   could  impede  the  ability  of  the  Company  to  achieve  broad
distribution  of products,  which would have a material  adverse effect upon the
business and financial condition of the Company.

           The Company does not maintain product  liability  insurance  coverage
and,  although the Company will attempt to obtain  product  liability  insurance
prior to the marketing of its existing or under development  products,  there is
no  assurance  that the  Company  will be able to obtain such  insurance  or, if
obtained,  that such  insurance can be acquired at a reasonable  cost or will be
sufficient to cover all possible liabilities. In the event of a

                                       -6-

<PAGE>



successful suit against the Company, lack or insufficiency of insurance coverage
could have a material adverse effect on the Company.

           CONTROL BY ALFRED J.  ROACH.  As at  September  30,  1996,  Alfred J.
Roach, Chairman of the Company's Board of Directors,  owned and had the power to
vote all 1,375,500  outstanding shares of the Company's Class B Common Stock and
513,250  shares of the  Company's  Class A Common  Stock  (and held  immediately
exercisable options to purchase an additional  1,017,500 shares of the Company's
Class A Common  Stock).  Each share of Class B Stock is  entitled  to ten votes,
while each share of Class A Common  Stock is entitled to one vote.  Accordingly,
at such date,  Mr. Roach was entitled to cast  approximately  47.6% of all votes
entitled to be cast by stockholders at meetings or by consent without a meeting.

           POTENTIAL  ISSUANCES OF SHARES.  In addition to the 16,210,673 shares
of Class A Common  Stock  outstanding  on September  30,  1996,  the Company had
10,328,504  shares of Class A Common  Stock  reserved  for  future  issuance  as
follows:  (i) 1,375,500  shares were  reserved for issuance  upon  conversion of
Class B Common Stock,  (ii) 3,010,250 shares were reserved for issuance upon the
exercise of  outstanding  options  under the  Company's  1986 Stock  Option Plan
(which  plan has expired as to the future  grant of  options) at prices  ranging
from  $1.50 to $10.00  per share,  (iii)  1,000,000  shares  were  reserved  for
issuance  upon the  exercise  of options  granted or which may be granted in the
future  under the  Company's  1996 Stock  Option  Plan,  under which  options to
purchase  135,000  shares,  at exercise  prices  ranging from $4.78 to $5.25 per
share, were outstanding, (iv) 487,500 shares were reserved for issuance upon the
exercise  of options  granted  or which may be  granted in the future  under the
Company's 1993  Non-Employee  Director Stock Option Plan, under which options to
purchase  80,000 shares at exercise prices ranging from $2.75 to $6.75 per share
were  outstanding,  (v) 3,052,500  shares,  representing  the maximum  number of
shares issuable upon conversion of $9,000,000  principal amount of the Company's
7%  Convertible  Debentures due September 30, 1998  (including  interest for one
calendar  quarter since any accrued but unpaid interest is also convertible into
Common  Stock),  were reserved for issuance upon  conversion of such  Debentures
(which are  convertible  to the extent of 25% of the  principal  amount  thereof
commencing on the earlier of the effective date a registration  statement  under
the  Securities  Act  (which the  Company is to file on or prior to October  20,
1996)  covering the  underlying  shares or December 29, 1996, and on each of the
30th, 60th and 90th days  thereafter,  at a conversion price equal to 83% of the
average  closing bid prices of the  Company's  Class A Common Stock for the five
consecutive  trading  days ending on the trading  day  immediately  prior to the
conversion date,  subject to a minimum conversion price of $3.00 per share and a
maximum  conversion  price of $8.00 per share,  provided that if the  conversion
price would  otherwise be less than $3.00 per share,  the  Debentureholder  will
also be  entitled  to  receive an amount of cash  equal to the  decrease  in the
number of shares  issued as a result of such  limit  multiplied  by such  market
price of the Company's  Class A Common Stock,  (vi) a minimum of 605,655  shares
were reserved for issuance upon conversion of the $1,900,000 principal amount of
the  Company's  8%  Convertible  Debentures  due  October 13,  1998,  which were
outstanding  on September 30, 1996 and  convertible  (with interest from October
13, 1995) at a price equal to the lesser of $3.375 or 85% of the average closing
bid price of the Company's  Class A Common Stock for the five trading days prior
to the conversion  date,  and (vii) 797,099  shares  (including the Shares) were
reserved  for  issuance  upon the  exercise  of warrants  and options  issued to
unaffiliated  third parties (at exercise  prices ranging from $2.25 to $6.75 per
share).  The issuance of reserved  shares  would  dilute the equity  interest of
existing  stockholders and could have a significant adverse effect on the market
price of the Company's  Class A Common Stock.  See also  "--Shares  Eligible for
Future Sale", below.

           NO  DIVIDENDS.  The  holders of Class A and Class B Common  Stock are
entitled to receive dividends when, as and if declared by the Board of Directors
out of funds legally available  therefor.  To date, the Company has not paid any
cash  dividends.  The payment of dividends,  if any, in the future is within the
discretion  of the  Board of  Directors  and  will  depend  upon  the  Company's
earnings,  its capital requirements and financial condition,  and other relevant
factors.  The Board does not intend to declare any dividends in the  foreseeable
future,  but  instead  intends to retain all  earnings,  if any,  for use in the
Company's  business  operations.  As the  Company  will be  required  to  obtain
additional  financing,  it is likely  that  there  will be  restrictions  on the
Company's ability to declare any dividends.

           SHARES  ELIGIBLE FOR FUTURE SALE. At September 30, 1996,  the Company
had outstanding  16,210,673  shares of Class A Common Stock and 1,375,500 shares
of Class B Common  Stock (which are  convertible  into Class A Common Stock on a
share for share basis). Of such shares, approximately 15,606,223 shares of Class
A Common Stock are presently freely  transferable  without restriction under the
Securities Act.


                                       -7-

<PAGE>



           Of  the  remaining   1,979,950   outstanding  shares  (including  the
1,375,500  shares of Class A Common Stock  issuable  upon  conversion of Class B
Common  Stock),  1,974,950  shares are held by  persons  who may be deemed to be
"affiliates"  of the Company and are presently  eligible for sale under Rule 144
promulgated  by the Commission  under the Securities Act ("Rule 144").  Rule 144
provides, in general, that all persons (including affiliates) who have satisfied
a two year holding  period with respect to "restricted  securities",  as well as
affiliates with respect to all other  securities  held by them, may,  subject to
fulfillment of certain requirements, sell within any three month period a number
of shares of Class A Common Stock which does not exceed the greater of 1% of the
then  outstanding  shares of Class A Common Stock or the average  weekly trading
volume in Class A Common  Stock  during the four  calendar  weeks  prior to such
sale.  Rule  144  also  permits,  under  certain  circumstances,   the  sale  of
"restricted securities" without any quantity or other limitation by a person who
is not an affiliate  of the Company (and has not been an affiliate  for at least
three  months  preceding  the sale) and who has  satisfied a three year  holding
period.  "Affiliates"  are persons who control,  are  controlled by or are under
common control with the Company.

           Upon issuance of the 100,000 Shares covered by this Prospectus,  such
Shares will also be freely transferable without restriction under the Securities
Act subject to applicable  Prospectus delivery  requirements.  In addition,  all
605,655  shares  that  may  be  issued  upon  conversion  of  the  Company's  8%
Convertible  Debentures are likely to be tradeable without restriction upon such
conversion,  and all shares  issuable  upon the  exercise  of options  under the
Company's  stock  option  plans  have  been  registered  for  issuance  with the
Securities Act and, unless held by "affiliates" of the Company (who will be able
to sell such shares by complying with Rule 144, discussed above, but without any
additional holding period), will be freely tradeable upon issuance. Furthermore,
the Company has filed separate registration  statements under the Securities Act
concerning the resale of (i) 5,000 shares of Class A Common Stock issued in June
1996 and 25,000  shares of Class A Common  Stock  subject to an option held by a
former  consultant  and (ii) 350,000  shares of Class A Common Stock  subject to
warrants held by the underwriter of a public offering  conducted by the Company.
In  addition,  the Company has  undertaken  to file,  on or prior to October 20,
1996, a  registration  statement  under the  Securities Act covering the maximum
number  of  shares  of  Class A  Common  Stock  (3,052,500)  issuable  upon  the
conversion of $9,000,000 principal amount of 7% Convertible Debentures issued by
the Company on September 30, 1996, which registration  statement will also cover
15,618  shares of Class A Common Stock subject to warrants held by the placement
agent for such 7% Convertible Debentures. See "--Potential Issuances of Shares",
above.

           Any sale of a substantial number of the foregoing shares could have a
significant adverse effect on the market price of the Class A Common Stock.

           NO  ASSURANCE  OF  CONTINUED   NASDAQ/NMS  LISTING.   The  Nasdaq/NMS
requires,  for continued  listing  thereon,  that a Company maintain among other
criteria,  tangible  net  worth of at least  $4,000,000  (to be  reduced  if the
Company attains  profitability)  and an aggregate market value of shares held by
persons other than officers or directors of at least  $1,000,000 (with a minimum
bid  price  of $1.00  per  share)  or such  aggregate  market  value of at least
$3,000,000 and tangible net worth of at least $4,000,000,  as well as compliance
with  various  other  rules.  There can be no  assurance  that the Company  will
continue to be eligible for trading on Nasdaq/NMS.


                                 USE OF PROCEEDS

           The Company will not receive any proceeds from the sale of the Shares
by the Selling  Stockholder.  However,  the Company will receive  $2.25 for each
Option  exercised  or an  aggregate  of $225,000  if all  Options are  exercised
(resulting  in the issuance of an aggregate of 100,000  shares of Class A Common
Stock).  Such proceeds  (before  giving effect to the expenses of this offering,
estimated at $5,000) will be used by the Company for working capital.


                               SELLING STOCKHOLDER

           The Sage  Group,  Inc.,  the  Selling  Stockholder,  has  advised the
Company that, except for the 100,000 shares subject to the Options (which shares
represent less than 1% of the outstanding  Class A Common Stock),  it is not the
beneficial  owner of any  shares  of  capital  stock of the  Company  and  that,
immediately  following the sale of the Shares offered hereby, will own no shares
of capital stock of the Company.


                                       -8-

<PAGE>



           The Options  were issued to the  Selling  Stockholder  pursuant to an
agreement  under which the Selling  Stockholder  served as a  consultant  to the
Company  from  March  1,  1995  until  February  29,  1996  for the  purpose  of
identifying  potential  opportunities  for the  Company to raise  funds  through
collaborating with third parties in the development and commercialization of the
Company's products and intellectual property and implementing such opportunities
(including with respect to two  collaborative  arrangements  entered into by the
Company).

           The  Registration  Statement (of which this Prospectus  forms a part)
was filed at the request of the Selling  Stockholder made in accordance with the
registration rights provided in the Options.  The Company has also agreed in the
Options to indemnify the Selling Stockholder and certain related persons against
certain liabilities,  including liabilities under the Securities Act, in certain
instances related to the Registration Statement.


                              PLAN OF DISTRIBUTION

           The Shares may be offered  for sale by the Selling  Stockholder  from
time  to  time  in  the   over-the-counter   market,  in  privately   negotiated
transactions or otherwise,  at market prices  prevailing at the time of sale, at
prices related to such  prevailing  market prices or at negotiated  prices.  The
Shares may be sold  directly by the Selling  Stockholder  or through one or more
broker-dealers.  Such  broker-dealers  may receive  compensation  in the form of
commissions,  discounts  or  concessions  from the  Selling  Stockholder  and/or
purchasers of Shares for whom such  broker-dealers  may act as agent, or to whom
they may sell as  principal,  or both  (which  compensation  as to a  particular
broker-dealer  may  be  in  excess  of  customary   commissions).   The  Selling
Stockholder  has agreed to limit the number of Shares it may sell in any week to
10,000  shares  unless the Company  consents to a larger  number of Shares.  The
Selling  Stockholder and such  broker-dealers may be deemed to be "underwriters"
within the meaning of the of Securities Act, and any discounts,  commissions and
concessions  and any profit realized on any sales of the Shares may be deemed to
be underwriting compensation.


                                  LEGAL MATTERS

           The  validity  of the Shares  offered  hereby  will be passed upon by
Parker Chapin Flattau & Klimpl, LLP, 1211 Avenue of the Americas,  New York, New
York 10036.


                                     EXPERTS

           The consolidated  financial  statements,  including the related notes
and schedules  thereto,  as of December 31, 1995 and for each of the three years
in the period then ended, which are incorporated by reference in this Prospectus
and  elsewhere  in the  Registration  Statement,  have  been  audited  by Arthur
Andersen LLP, independent public accountants, as indicated in their reports with
respect thereto,  and are included herein in reliance upon the authority of said
firm as experts in accounting and auditing in giving said reports.



                                       -9-

<PAGE>

=======================================  =======================================
     NO PERSON HAS BEEN AUTHORIZED IN
  CONNECTION  WITH THE OFFERING  MADE
  HEREBY TO GIVE ANY  INFORMATION  OR
  TO  MAKE  ANY   REPRESENTATION  NOT
  CONTAINED IN THIS  PROSPECTUS  OR A
  SUPPLEMENT TO THIS PROSPECTUS, AND,
  IF GIVEN OR MADE, SUCH  INFORMATION                  100,000 SHARES          
  OR   REPRESENTATION   MUST  NOT  BE                                          
  RELIED    UPON   AS   HAVING   BEEN                                          
  AUTHORIZED  BY  THE  COMPANY,   THE        AMERICAN BIOGENETIC SCIENCES, INC.
  SELLING  STOCKHOLDER  OR ANY  OTHER                                          
  PERSON. NEITHER THIS PROSPECTUS NOR                                          
  ANY  SUPPLEMENT TO THIS  PROSPECTUS                   COMMON STOCK           
  CONSTITUTES  AN  OFFER TO SELL OR A                                          
  SOLICITATION  OF AN  OFFER  TO BUY,                                          
  ANY   SECURITIES   OTHER  THAN  THE                                          
  SECURITIES  TO WHICH IT  RELATES OR                                          
  AN    OFFER    TO   SELL   OR   THE                                          
  SOLICITATION  OF AN  OFFER  TO  BUY                                          
  SUCH SECURITIES IN ANY JURISDICTION                                          
  WHERE, OR TO ANY PERSON TO WHOM, IT                    PROSPECTUS            
  IS  UNLAWFUL  TO MAKE SUCH AN OFFER                                          
  OR   SOLICITATION.    NEITHER   THE                                          
  DELIVERY OF THIS PROSPECTUS NOR ANY                                          
  SUPPLEMENT TO THIS  PROSPECTUS  NOR                                          
  ANY   SALE   MADE    HEREUNDER   OR                                          
  THEREUNDER    SHALL,    UNDER   ANY                                          
  CIRCUMSTANCES,      CREATE      ANY                                          
  IMPLICATION  THAT THERE HAS BEEN NO                                          
  CHANGE  IN  THE   AFFAIRS   OF  THE                                          
  COMPANY  SINCE  THE DATE  HEREOF OR                                          
  THEREOF  OR  THAT  THE  INFORMATION                                          
  CONTAINED  HEREIN IS  CORRECT AS OF                                          
  ANY TIME SUBSEQUENT TO THE DATES AS                                          
  OF  WHICH   SUCH   INFORMATION   IS                                          
  FURNISHED.                                          October 16, 1996         
                                                                               
                                                                               
         -----------------                                                     
                                                                               
         TABLE OF CONTENTS                                                     
                                  Page                                         
                                  ----                                         
Available Information.............. 2        
Information Incorporated by
 Reference......................... 2
The Company........................ 3
Risk Factors....................... 3
Use of Proceeds.................... 8
Selling Stockholder................ 8
Plan of Distribution............... 9
Legal Matters...................... 9
Experts............................ 9


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