AMERICAN BIOGENETIC SCIENCES INC
DEFS14A, 1998-10-14
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                            SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Filed by the Registrant [X]

Filed by a party other than the Registrant [   ]

Check the appropriate box:

   
[ ]  Preliminary Proxy Statement
[ ]  Confidential,  for  Use  of the  Commission  Only  (as  permitted  by  Rule
     14a-6(e)(2)) 
[X] Definitive Proxy Statement 
[ ] Definitive  Additional Materials
[ ] Soliciting Material Pursuant to ss.240.14a-11(c) or ss.240.14a-12
    

                       American Biogenetic Sciences, Inc.
                 ---------------------------------------------
                (Name of Registrant as Specified in Its Charter)

              ----------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[X]      No fee required

[ ]      Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11

         1)    Title of each class of securities to which transaction applies:

         2)    Aggregate number of securities to which transaction applies:

         3)    Per  unit  price  or other  underlying  value  of  transaction
               computed  pursuant  to  Exchange  Act Rule 0-11 (Set forth the
               amount on which the filing fee is calculated  and state how it
               was determined):

         4)    Proposed maximum aggregate value of transaction:

         5)    Total fee paid:

[ ]      Fee paid previously with preliminary materials.

[ ]      Check box if any part of the fee is offset as  provided  by  Exchange
         Act Rule  0-11(a)(2)  and identify the filing for which the  offsetting
         fee was paid  previously.  Identify the previous filing by registration
         statement number, or the Form or Schedule and the date of its filing.

         1)       Amount Previously Paid:

         2)       Form, Schedule or Registration Statement No.:

         3)       Filing Party:

         4)       Date Filed:

<PAGE>

                       AMERICAN BIOGENETIC SCIENCES, INC.

                                1375 Akron Street
                            Copiague, New York 11726
                              --------------------

                    NOTICE OF SPECIAL MEETING OF STOCKHOLDERS
                              --------------------

                                November 11, 1998
                              --------------------

         NOTICE IS  HEREBY  GIVEN  that a Special  Meeting  of  Stockholders  of
American Biogenetic Sciences, Inc., a Delaware corporation (the "Company"), will
be held at the Huntington Hilton, 598 Broad Hollow Road, Melville,  New York, on
Wednesday, November 11, 1998 at 10:30 a.m., Eastern Standard Time. The following
matters are to be presented for consideration at the meeting:

   
         1. Authorization of an Amendment to the Company's Restated  Certificate
of Incorporation in order to effect a stock combination (reverse split) pursuant
to which the  Company's  outstanding  shares of Class A Common Stock and Class B
Common Stock would be exchanged for new shares of Class A Common Stock and Class
B Common Stock,  respectively,  in an exchange ratio to be approved by the Board
of  Directors,  ranging from one newly  issued  share for each four  outstanding
shares to one newly issued share for each eight outstanding shares;

         2. To approve the issuance,  in addition to the up to 4,000,000  shares
of Class A Common Stock which the Company has agreed to issue,  of all shares of
Class A Common  Stock  which  the  Company  would  be  entitled  to  issue  upon
conversion of the Company's 5% Convertible Debentures due May 20, 2001; and
    

         3. The  transaction  of such other business as may properly come before
the meeting or any adjournments or postponements thereof.

         The close of  business  on  September  25,  1998 has been  fixed as the
record date for the determination of stockholders  entitled to notice of, and to
vote at, the meeting and any  adjournments or postponements  thereof.  A list of
such  stockholders  will be open  for  examination  by any  stockholder  for any
purpose germane to the meeting,  during ordinary business hours, for a period of
at least ten days prior to the meeting at the offices of the Company, 1375 Akron
Street, Copiague, New York.

                                             By Order of the Board of Directors,

   
                                                    /s/  Timothy J. Roach
                                                         Secretary
Copiague, New York
October 14, 1998
    

WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING,  PLEASE COMPLETE, DATE AND SIGN
THE  ENCLOSED  PROXY AND MAIL IT PROMPTLY IN THE  ENCLOSED  ENVELOPE IN ORDER TO
ASSURE  REPRESENTATION  OF YOUR  SHARES.  NO  POSTAGE IS NEEDED IF MAILED IN THE
UNITED STATES.

<PAGE>


                       AMERICAN BIOGENETIC SCIENCES, INC.

                                1375 Akron Street
                            Copiague, New York 11726
                              --------------------

                                 PROXY STATEMENT
                              --------------------

   
         This Proxy  Statement  is  furnished  to the  holders of Class A Common
Stock  ("Class A Common  Stock") and to the sole holder of Class B Common  Stock
("Class B Common Stock" and, together with Class A Common Stock, "Common Stock")
of American  Biogenetic  Sciences,  Inc. (the  "Company") in connection with the
solicitation  by the  Board  of  Directors  of the  Company  of  proxies  in the
accompanying  form  ("Proxy" or  "Proxies")  to be used at a Special  Meeting of
Stockholders  of the Company (the  "Meeting") to be held on Wednesday,  November
11, 1998, at 10:30 a.m.,  Eastern Standard Time, at the Huntington  Hilton,  598
Broad Hollow Road, Melville, New York, and at any adjournments and postponements
thereof,  for the  purposes  set forth in the  accompanying  Notice  of  Special
Meeting.  It is  anticipated  that this Proxy  Statement and the Proxies will be
mailed to stockholders on or about October 14, 1998.  Proxies properly  executed
and received in time for the Meeting will be voted. A stockholder  who signs and
returns a Proxy has the power to revoke it at any time before it is exercised by
giving written notice of revocation to the Company, 1375 Akron Street, Copiague,
New York 11726, Attention: Secretary, by a duly executed proxy of later date, or
by voting in person at the Meeting.

         The close of  business  on  September  25,  1998 has been  fixed as the
record date for the determination of stockholders  entitled to notice of, and to
vote at, the Meeting  (the "Record  Date").  There were  outstanding,  as of the
close of business on that date,  20,765,524  shares of Class A Common  Stock and
1,775,500  shares  of Class B Common  Stock.  A  majority  of the  total of such
outstanding shares of Class A Common Stock and Class B Common Stock, represented
in person or by Proxy at the Meeting, is required to constitute a quorum for the
transaction of business at the Meeting. Holders of Class A Common Stock have one
vote for each  share  thereof  held of record  and the  holder of Class B Common
Stock has ten votes for each share  thereof  held of record.  The Class A Common
Stock and Class B Common  Stock will vote as one class on all  matters  proposed
herein to be submitted to stockholders at the Meeting.

         Unless otherwise specified, all Proxies received will be voted in favor
of each of (i) authorization of the proposed Amendment to the Company's Restated
Certificate of Incorporation ( the "Amendment") in order to effect a combination
(the "Reverse Split") of each of the Company's  outstanding Class A Common Stock
and Class B Common Stock (the "Reverse Split Proposal") and (ii) approval of the
issuance,  in addition to the shares  which the Company has agreed to issue,  of
all shares of Class A Common Stock which the Company  would be entitled to issue
upon conversion of the Company's 5% Convertible Debentures due May 20, 2001 (the
"Additional Issuance Proposal"). The Board of Directors does not intend to bring
before the Meeting any matter other than those specifically  described above and
knows of no matters  other than the  foregoing to come before the  Meeting.  The
Board of  Directors  has not  received  notice  of and is not aware of any other
matters  that are to be  presented  to  stockholders  for  formal  action at the
Meeting.  If, however,  any other matters or motions come before the Meeting, it
is the  intention of the persons  named in the  accompanying  Proxy to vote such
Proxy in accordance  with their  judgment on such matters or motions,  including
any matters dealing with the conduct of the Meeting.

         Proxies submitted which contain  abstentions or broker nonvotes will be
deemed  present at the Meeting in determining  the presence of a quorum.  Shares
subject to abstentions with respect to any matter are considered shares entitled
to, and voted,  with respect to that matter.  Shares subject to broker  nonvotes
with respect to any matter are not  considered  as shares  entitled to vote with
respect to that matter.  Since approval of the Reverse Split  Proposal  requires
the affirmative  vote of a majority of the votes  represented by all outstanding
shares of Class A Common Stock and Class B Common  Stock,  voting  together as a
single class,  abstentions and broker non-votes will effectively  serve as votes
"against" the Reverse Split Proposal.  Since approval of the Additional Issuance
Proposal  requires  the  affirmative  vote of a majority of the votes of Class A
Common Stock and Class B Common  Stock  present,  in person or by proxy,  at the
Meeting  and  entitled  to vote on this  proposal,  voting  together as a single
class,  abstentions  will,  in  effect,  be deemed  negative  votes,  but broker
nonvotes will not affect the results of the vote thereon.
    

<PAGE>


                          SECURITY HOLDINGS OF CERTAIN
                      STOCKHOLDERS, MANAGEMENT AND NOMINEES

         The following  table sets forth  information as at the Record Date with
respect to the  beneficial  ownership of the Company's  Class A Common Stock and
Class B Common Stock by (i) each person known by the Company to beneficially own
more than 5% of the outstanding shares of Class A Common Stock or Class B Common
Stock,  (ii) each director of the Company,  (iii) the Company's  Chief Executive
Officer and each other executive officer whose annual cash compensation for 1997
exceeded  $100,000 and (iv) all executive  officers and directors of the Company
as a group. Each share of Class A Common Stock is entitled to one vote per share
while each share of Class B Common Stock is entitled to ten votes per share. The
Company  understands that, except as noted below, each beneficial owner has sole
voting and  investment  power with  respect to all shares  attributable  to such
owner.
<TABLE>
<CAPTION>
   
                                          Class A Common Stock(1)         Class B Common Stock
                                        --------------------------     ------------------------
                                                          Percent                          Percent
Beneficial Owner                        No. Shares        of Class     No. Shares         of Class
- -----------------                      ------------       --------     ----------         --------

<S>                              <C>                     <C>       <C>              <C> 
Alfred J. Roach (2)                    3,870,750  (2)       16.3%     1,775,500 (2)            100%

Stephen H. Ip                            105,001  (3)         *              ---               ---

Ellena M. Byrne                          212,500  (3)(4)     1.0%            ---               ---

Timothy J. Roach                         617,500  (3)        2.9%            ---               ---

Josef C. Schoell                         127,750  (3)         *              ---               ---

Gustav V. R. Born                         23,750  (3)         *              ---               ---

Joseph C. Hogan                           50,000  (3)         *              ---               ---

William G. Sharwell                       45,000  (3)         *              ---               ---

All executive officers and directors
  as a group (11 persons, including
   the foregoing)                      5,239,251  (5)       21.0%     1,775,500                100%
- ----------------------------
</TABLE>

(1)   Asterisk  indicates less than one percent.  Shares of Class A Common Stock
      subject to issuance  upon  conversion of Class B Common Stock into Class A
      Common  Stock and upon  exercise of options that were  exercisable  on, or
      become  exercisable  within 60 days after,  the Record Date are considered
      owned by the holder thereof and  outstanding for purposes of computing the
      percentage of outstanding  Class A Common Stock that would be beneficially
      owned by such  person,  but  (except  for the  computation  of  beneficial
      ownership  by all  executive  officers  and  directors as a group) are not
      considered  outstanding  for  purposes  of  computing  the  percentage  of
      outstanding Class A Common Stock owned by any other person.

(2)   The address of Mr.  Roach is Route 2 - Kennedy  Avenue,  Guaynabo,  Puerto
      Rico  00657.  Beneficial  ownership  of  Class  A  Common  Stock  includes
      1,775,500  shares of Class A Common Stock issuable upon  conversion of the
      same  number  of shares of Class B Common  Stock and  1,160,000  shares of
      Class A Common Stock subject to outstanding  options.  Excludes  1,224,500
      shares of Class B Common  Stock  purchased  by Mr.  Roach after the Record
      Date and the Class A Common Stock issuable upon conversion thereof.  After
      giving effect thereto, the percentage of Class A Common Stock beneficially
      owned by Mr. Roach is 20.4%.
    
(3)   Includes  shares of Class A Common  Stock  subject to options as  follows:
      Stephen H. Ip, 100,001;  Ellena M. Byrne, 172,500 (including 15,000 shares
      subject to options held by her husband);  Timothy J. Roach, 607,500; Josef
      C. Schoell,  118,750;  Gustav V.R. Born, 23,750;  Joseph C. Hogan, 30,000;
      and William G. Sharwell, 35,000.

(4)   Includes  15,000  shares owned by Ms.  Byrne's son. The inclusion of these
      amounts  should not be  construed  as an  admission  that Ms. Byrne is the
      beneficial owner of these shares.

(5)   Includes 1,775,500 shares of Class A Common Stock issuable upon conversion
      of the same number of shares of Class B Common Stock and 2,405,001  shares
      of Class A Common Stock subject to outstanding options.


                                       -2-
<PAGE>

                                   PROPOSAL 1.

                   TO AUTHORIZE AN AMENDMENT TO THE COMPANY'S
                    RESTATED CERTIFICATE OF INCORPORATION TO
                     ENABLE THE BOARD OF DIRECTORS TO EFFECT
                  A REVERSE SPLIT OF EACH CLASS OF COMMON STOCK

General

   
        The Company's  Board of Directors has  unanimously  adopted  resolutions
proposing,  declaring advisable and recommending that stockholders  authorize an
Amendment  to  the  Company's   Restated   Certificate  of  Incorporation   (the
"Amendment")  to (i) effect a stock  combination  (reverse  stock  split) of the
Company's  outstanding  shares of each of its  Class A Common  Stock and Class B
Common Stock (the  "Reverse  Split") and (ii) provide for the payment of cash in
lieu of fractional shares otherwise issuable in connection therewith. There will
be no change in the number of the Company's  authorized shares of Class A Common
Stock or Class B Common Stock and no change in the par value of either class.

         If the  Reverse  Split is  approved,  the Board  will  have  authority,
without further  stockholder  approval,  to effect the Reverse Split pursuant to
which the  Company's  outstanding  shares  (the "Old  Shares") of Class A Common
Stock and Class B Common  Stock  would be  exchanged  for new  shares  (the "New
Shares") of Class A Common Stock and Class B Common Stock,  respectively,  in an
exchange  ratio to be approved by the Board of  Directors,  ranging from one New
Share for each four Old Shares to one New Share for each eight Old  Shares.  The
number of Old Shares for which each New Share is to be  exchanged is referred to
as the "Exchange Number". The Exchange Number may, within such range, be a whole
number or a whole number and fraction of a whole number.  The Reverse Split will
be effected  simultaneously  for each of Class A Common Stock and Class B Common
Stock and Exchange Number will be the same for each class.
    

        In addition,  the Board will have the  authority to determine  the exact
timing of the effective date of the Reverse  Split,  which may be any time prior
to June 30, 1999, without further stockholder approval. Such timing and Exchange
Number will be determined  in the judgment of the Board of  Directors,  with the
intention of maximizing the Company's  ability to remain in compliance  with the
continued  listing  maintenance  requirements  of The Nasdaq Stock Market,  Inc.
("Nasdaq") and other intended  benefits of the Reverse Split to stockholders and
the  Company.  See  "--Purpose  of the Reverse  Split,"  below.  The text of the
proposed  Amendment  (subject to  inserting  the  effective  date of the Reverse
Split,  the Exchange  Number and the per share amount to be paid for  fractional
shares) is set forth in Exhibit A to this Proxy Statement.

   
        The  Board  of  Directors  also  reserves  the  right,   notwithstanding
stockholder approval and without further action by stockholders,  to not proceed
with the Reverse  Split,  if, at any time prior to filing the Amendment with the
Secretary of State of the State of Delaware, the Board of Directors, in its sole
discretion, determines that the Reverse Split is no longer in the best interests
of the Company  and its  stockholders.  The Board of  Directors  may  consider a
variety of factors in determining  whether or not to implement the Reverse Split
and in determining  the Exchange Number  including,  but not limited to, overall
trends in the stock market,  recent  changes and  anticipated  trends in the per
share  market  price  of the  Company's  Class  A  Common  Stock,  business  and
transactional  developments  and the Company's  actual and  projected  financial
performance.
    

        The Reverse Split will not change the proportionate  equity interests of
the  Company's  stockholders,  nor will the  respective  voting rights and other
rights of stockholders be altered, except for possible immaterial changes due to
the Company's purchase of fractional shares. The Common Stock issued pursuant to
the Reverse  Split will remain  fully paid and  nonassessable.  The Company will
continue to be subject to the periodic reporting  requirements of the Securities
Exchange Act of 1934.

                                       -3-
<PAGE>


Purposes of the Reverse Split

        The Company's Class A Common Stock is quoted on Nasdaq's National Market
("Nasdaq/NMS").  In order for the Class A Common  Stock to continue to be quoted
thereon,  the Company and its Class A Common  Stock are  required to continue to
comply with various listing maintenance  standards  established by Nasdaq. Among
other  things,  as such  requirements  pertain to the  Company,  the  Company is
required to maintain an adjusted  tangible net worth of at least  $4,000,000 and
its Class A Common Stock must have an  aggregate  market value of shares held by
persons  other  than  officers  and  directors  ("public  float")  of  at  least
$5,000,000,  at least 400  persons who own at least 100 shares and a minimum bid
price of at least $1.00 per share.

   
        Under Nasdaq's listing maintenance  standards,  if the closing bid price
of the Class A Common  Stock is under  $1.00 per share for a thirty  consecutive
business days and does not  thereafter  regain  compliance  for a minimum of ten
consecutive business days during the ninety calendar days following notification
by  Nasdaq,  Nasdaq may  delist  the Class A Common  Stock  from  trading on the
Nasdaq/NMS.  If a delisting were to occur,  the Class A Common Stock would trade
on the OTC Bulletin  Board or in the "pink  sheets"  maintained  by the National
Quotation  Bureau,  Inc. Such  alternatives are generally  considered to be less
efficient  markets.  On September 24, 1998,  the Company  received a letter from
Nasdaq advising it that the Company's  Common Stock had not met Nasdaq's minimum
bid price closing  requirement for thirty consecutive  trading days and that, if
the Company is unable to demonstrate compliance with this requirement during the
ninety  calendar days ending December 23, 1998, its Class A Common Stock will be
delisted  at the  opening of  business  on  December  28,  1998  (subject to the
Company's  right for a hearing  and stay of the  delisting  during  the  hearing
period). The Company understands that it is Nasdaq's position that an ability to
demonstrate  sustained  compliance is also required to achieve  compliance  with
this  requirement.  The principal  purpose of the Reverse  Split  Proposal is to
increase the market price of the Company's Class A Common Stock above the Nasdaq
minimum bid requirement  (which does not adjust for the Reverse  Split).  Giving
the Board authority to implement the Reverse Split will avoid the need to call a
special meeting of, or seek consents from,  stockholders  under time constraints
to authorize a reverse split should it become necessary in order to seek to meet
Nasdaq's listing maintenance criteria.

        In addition,  the Company's 5% Convertible  Debentures due May 20, 2001,
of which  $3,917,000  principal  amount was  outstanding  on September  30,1998,
provide that it shall be an event of default  thereunder if, among other things,
the  Company's  Class A Common  Stock  shall  cease to be listed on Nasdaq for a
period of five  consecutive  trading days, in which case (i) the holders thereof
may, in their discretion,  consider the debentures  immediately due and payable,
obligating the Company to redeem the debentures at a redemption price of 125% of
the then outstanding principal amount thereof,  plus accrued interest,  and (ii)
the interest  rate on the  debentures is to be  permanently  increased to 7% per
annum and, if the Company fails to redeem debentures when and if required, by an
additional 2% per annum for each of the second and third months thereafter,  and
1% per annum for each month thereafter, that the debentures are not so redeemed.

        Furthermore,   the  Company  believes  that  maintaining  the  Company's
Nasdaq/NMS listing may provide the Company with a broader market for its Class A
Common Stock and facilitate the use of the Class A Common Stock in  acquisitions
and  financing  transactions  in which the Company  may engage.  There can be no
assurance  that,  even after  effectuating  the Reverse Split,  the Company will
continue to meet the minimum bid price and otherwise  meet the  requirements  of
Nasdaq for continued inclusion for trading on Nasdaq/NMS.
    

                                       -4-
<PAGE>



Certain Effects of the Reverse Split

        The following  tables  illustrate  the principal  effects of the Reverse
Split on the Company's Common Stock:
<TABLE>
<CAPTION>
                                                                                            After 1-for-6 
                                                Prior to          After 1-for-4            Reverse            After 1-for-8
                                              Reverse Stock       Reverse Stock             Stock             Reverse Stock
Number of Shares                                  Split               Split                 Split                  Split
- ----------------                              -------------       -------------          --------------       --------------

<S>                                            <C>                 <C>                <C>                  <C>       
Class A Common Stock, .001 par
   value Authorized......................           50,000,000          50,000,000         50,000,000           50,000,000   
   Outstanding (1)(2)....................           20,765,524           5,191,381          3,460,920            2,595,690
   Available for Future Issuance.........           29,234,476          44,808,619         46,539,080           47,404,310
Class B Common Stock Authorized..........            3,000,000           3,000,000          3,000,000            3,000,000
   Outstanding (2).......................            1,775,500             443,875            295,916              221,937
   Available for Future Issuance.........            1,224,500           2,556,125          2,704,084            2,778,063

Financial Data (2)(3)
- ---------------------
Stockholders' Equity
   Class A Common Stock..................      $        21,000   $           5,000  $           4,000    $           3,000
   Class B Common Stock..................                2,000               1,000              1,000                    0
   Additional Paid-in Capital                       58,773,000          58,790,000         58,791,000           58,793,000
Deficit Accumulated During
   Development Stage.....................          (52,328,000)        (52,328,000)       (52,328,000)         (52,328,000)
                                                  ------------        ------------       ------------         ------------
   Total Stockholders' Equity............       $    6,468,000      $    6,468,000      $   6,468,000        $   6,468,000
                                                ==============      ==============      =============        =============
Net (Loss) per share:
   Six months ended June 30, 1998                       $(0.14)             $(0.54)            $(0.81)              $(1.08)
   Year ended December 31, 1997                         $(0.35)             $(1.41)            $(2.12)              $(2.83)
   Book Value Per Common Share...........                $0.31               $1.25              $1.87                $2.49

</TABLE>

   -----------------------------
(1)  Gives  effect to the Reverse  Split as if it  occurred on the Record  Date,
     subject to adjustment  resulting from the repurchase of fractional  shares.
     Excludes, on a pre-Reverse Split basis,  1,775,500 shares of Class A Common
     Stock  subject to potential  issuance upon  conversion  of the  outstanding
     shares of Class B Common  Stock;  4,728,291  shares of Class A Common Stock
     which  were  subject  to  outstanding   options  and  warrants;   1,355,250
     additional  shares of Class A Common  Stock  which were  available  for the
     grant of future  options  under the  Company's  stock option  plans;  up to
     3,945,014  shares of Class A Common  Stock which were  subject to potential
     issuance upon  conversion of the  Debentures  (see "Approval of Issuance of
     Additional  Shares Upon  Conversion  of 5%  Convertible  Debentures");  and
     1,399,384  shares of Class A Common Stock  reserved for potential  issuance
     upon  conversion of other  debentures.  Upon  effectiveness  of the Reverse
     Split,  each option,  warrant and conversion right would entitle the holder
     to  acquire  a number  of shares  equal to the  number of shares  which the
     holder was entitled to acquire  prior to the Reverse  Split  divided by the
     Exchange Number at the exercise or conversion  price in effect  immediately
     prior to the Reverse Split multiplied by the Exchange Number.
(2)  Does not give effect to 1,224,500  shares of Class B Common Stock purchased
     by  Alfred J.  Roach  after the  Record  Date and the Class A Common  Stock
     issuable upon conversion thereof.
(3)  Balance  sheet data gives effect to the Reverse  Split as if it occurred on
     June 30, 1998,  subject to  adjustment  resulting  from the  repurchase  of
     fractional shares.
    
                                       -5-

<PAGE>

   
        Stockholders  should  recognize that if the Reverse Split is effectuated
they will own a fewer number of shares than they  presently  own (a number equal
to the number of shares owned  immediately  prior to the filing of the Amendment
divided by the  Exchange  Number).  While the Company  expects  that the Reverse
Split  will  result in an  increase  in the  market  price of the Class A Common
Stock, there can be no assurance that the Reverse Split will increase the market
price of the Class A Common Stock by a multiple equal to the Exchange  Number or
result in the  permanent  increase in the market price (which is dependent  upon
many factors,  including the Company's performance and prospects).  Also, should
the market price of the Company's  Class A Common Stock decline,  the percentage
decline may be greater  than would  pertain in the  absence of a Reverse  Split.
Furthermore,  the  possibility  exists that liquidity in the market price of the
Class A Common Stock could be adversely affected by the reduced number of shares
that would be  outstanding  after the Reverse  Split.  In addition,  the Reverse
Split will increase the number of  stockholders  of the Company who own odd-lots
(less than 100 shares). Stockholders who hold odd-lots typically will experience
an increase in the cost of selling their shares,  as well as greater  difficulty
in  effecting  such  sales.  Consequently,  there can be no  assurance  that the
Reverse Split will achieve the desired results that have been outlined above.
    

Procedure for Effecting Reverse Split and Exchange of Stock Certificates

   
        If the Amendment is approved by the Company's  stockholders,  and if the
Board  of  Directors  still  believes  that  the  Reverse  Split  is in the best
interests  of the  Company  and its  stockholders,  the  Company  will  file the
Amendment  with the  Secretary of State of the State of Delaware at such time as
the Board has determined the  appropriate  Exchange  Number and the  appropriate
effective time for such split.  The Board may delay  effecting the Reverse Split
until June 30, 1999 without resoliciting such stockholder approval.  The Reverse
Split will become  effective on the date of filing the Amendment (the "Effective
Date").  Beginning on the Effective  Date,  each  certificate  representing  Old
Shares will be deemed for all  corporate  purposes to evidence  ownership of New
Shares.

        As soon as practicable  after the Effective Date,  stockholders  will be
notified  that the Reverse  Split has been  effected  and of the exact  Exchange
Number.  The Company's  transfer agent will act as exchange agent (the "Exchange
Agent") for purposes of implementing the exchange of stock certificates. Holders
of Old Shares will be asked to  surrender  to the  Exchange  Agent  certificates
representing Old Shares in exchange for certificates  representing New Shares in
accordance  with the procedures to be set forth in a letter of transmittal to be
sent by the Company.  No new certificates  will be issued to a stockholder until
such stockholder has surrendered such stockholder's  outstanding  certificate(s)
together with the properly  completed and executed  letter of transmittal to the
Exchange Agent. Stockholders should not destroy any stock certificate and should
not submit any certificates until requested to do so.
    

Fractional Shares

   
        No scrip or fractional  certificates  will be issued in connection  with
the  Reverse  Split.  Stockholders  who  otherwise  would be entitled to receive
fractional  shares because they hold a number of Old Shares not evenly divisible
by the Exchange Number,  will be entitled,  upon surrender to the Exchange Agent
of certificates representing such shares, to a cash payment in lieu thereof at a
price equal to the fraction to which the stockholder would otherwise be entitled
multiplied by the closing price of the Class A Common Stock,  as reported in The
Wall Street Journal,  on the last trading day prior to the Effective Date (or if
such price is not  available,  the average of the last bid and ask prices of the
Class A  Common  Stock on such day or other  price  determined  by the  Board of
Directors).  The  ownership  of a fractional  interest  will not give the holder
thereof any voting, dividend, or other rights except to receive payment therefor
as described herein.
    

        Stockholders should be aware that, under the escheat laws of the various
jurisdictions  where stockholders  reside,  where the Company is domiciled,  and
where the funds will be deposited, sums due for fractional interests

                                       -6-
<PAGE>

that are not timely  claimed after the Effective Date may be required to be paid
to the designated agent for each such  jurisdiction,  unless  correspondence has
been received by the Company or the Exchange Agent concerning  ownership of such
funds within the time permitted in such jurisdiction.  Thereafter,  stockholders
otherwise  entitled  to  receive  such  funds  will have to seek to obtain  them
directly from the state to which they were paid.

No Dissenter's Rights

        Under Delaware law,  stockholders are not entitled to dissenter's rights
with respect to the proposed Amendment.

Federal Income Tax Consequences of the Reverse Split

   
        The  following  is a summary  of  certain  material  federal  income tax
consequences of the Reverse Split, and does not purport to be complete.  It does
not discuss any state,  local,  foreign or minimum income or other U.S.  federal
tax consequences. Also, it does not address the tax consequences to holders that
are subject to special tax rules, such as banks, insurance companies,  regulated
investment companies, personal holding companies, foreign entities,  nonresident
alien  individuals,  broker-dealers and tax-exempt  entities.  The discussion is
based on the  provisions of the United States  federal  income tax law as of the
date hereof,  which is subject to change retroactively as well as prospectively.
This summary also assumes that the Old Shares were,  and the New Shares will be,
held as a "capital  asset," as defined in the Internal  Revenue Code of 1986, as
amended  (generally,  property  held for  investment).  The tax  treatment  of a
stockholder may vary depending upon the particular  facts and  circumstances  of
such stockholder.  Each stockholder  should consult with such  stockholder's own
tax advisor with respect to the consequences of the Reverse Split.
    

        No gain or loss should be  recognized  by a  stockholder  of the Company
upon such  stockholder's  exchange of Old Shares for New Shares  pursuant to the
Reverse  Split  (except to the extent of any cash received in lieu of a fraction
of a New Share).  Cash  payments in lieu of a  fractional  New Shares  should be
treated as if the  fractional  share  were  issued to the  stockholder  and then
redeemed by the Company for cash. A Company  stockholder  receiving such payment
should  recognize  gain or loss equal to the  difference,  if any,  between  the
amount of cash  received and the  stockholder's  basis in the  fractional  share
(determined as provided  below).  Such gain or loss will be capital gain or loss
if the  payment  of cash in lieu of the  fractional  share is a mere  mechanical
rounding off of fractions and not separately  bargained for  consideration,  and
the payment is "not  essentially  equivalent to a dividend"  with respect to the
stockholder under the federal income tax law. For this purpose, a payment is not
essentially  equivalent to a dividend if it results in a "meaningful  reduction"
in the stockholder's percentage interest in the Company, taking into account the
constructive  ownership rules and redemptions of fractional  shares from all the
stockholders. The Internal Revenue Service has ruled publicly that any reduction
in the percentage  interest of a small minority  stockholder in a  publicly-held
corporation who exercises no control over corporate  affairs should constitute a
meaningful reduction.

        The aggregate tax basis of the New Shares  received in the Reverse Split
(including any fraction of a New Share deemed to have been received) will be the
same as the  stockholder's  aggregate  tax  basis  in the Old  Shares  exchanged
therefor.  The stockholder's  holding period for the New Shares will include the
period  during  which the  stockholder  held the Old Shares  surrendered  in the
Reverse Split.

Required Vote

   
        Authorization of the proposed Amendment requires the affirmative vote of
a majority of the votes represented by all outstanding  shares of Class A Common
Stock and Class B Common  Stock,  voting  together  as one  class,  with Class A
Common Stock having one vote per share and Class B Common Stock having ten votes
per share. The Board of Directors unanimously  recommends that stockholders vote
FOR this proposal.
    


                                       -7-
<PAGE>


                                   PROPOSAL 2.

                    APPROVAL OF ISSUANCE OF ADDITIONAL SHARES
                  UPON CONVERSION OF 5% CONVERTIBLE DEBENTURES

General

        On May 20,  1998,  the Company  completed a private  placement  to three
unaffiliated  investors  (the  "Investors")  of an aggregate of $4,000,000 of 5%
Convertible  Debentures due May 20, 2001 (the  "Debentures") and three series of
Warrants to purchase up to an aggregate of 261,228 shares  (subject to reduction
in certain instances) of the Company's Class A Common Stock at an exercise price
of $1.9194 per share (the "Warrants").

   
        The  Debentures  have  been  convertible  to  the  extent  of 25% of the
principal  amount thereof  commencing on September 17, 1998,  with an additional
25% of the principal amount of the Debentures becoming first convertible on each
of October 17,  1998,  November  16,  1998 and  December  16,  1998  (subject to
potential  acceleration in certain instances) at a conversion price equal to 87%
(if converted before November 17, 1998), 86% (if converted  between November 17,
1998 and February 14, 1999), 85% (if converted between February 15, 1999 and May
20, 1999) or 84% (if converted after May 20, 1999), respectively, of the average
of the closing  bid prices of the  Company's  Class A Common  Stock for the five
consecutive  trading days  immediately  preceding  the date of conversion of the
Debentures;  provided,  however,  that in no event may the  conversion  price be
greater  than $1.9375 per share,  which was 125% of such average  price over the
five  consecutive  trading days prior to the  consummation  of the  transaction.
Interest on the Debentures is payable only on maturity,  conversion,  redemption
or when other payment is made on the  Debentures  in cash or, if registered  for
resale under the Securities Act of 1933, as amended (the  "Securities  Act"), in
shares of the Company's Class A Common Stock valued at the applicable  Debenture
conversion   price.   Any  Debenture   outstanding  on  May  20,  2001  will  be
automatically  converted as of that date.  In addition,  the Company may require
conversion of outstanding Debentures after May 20, 2000 if the closing bid price
of its Class A Common Stock on the trading day immediately  preceding its giving
of notice of  conversion  to  Debenture  holders  is at least  $3.0625.  Through
September 30, 1998,  $83,000  principal  amount of the Debentures,  plus accrued
interest thereon,  were converted into an aggregate of 184,524 shares of Class A
Common Stock at an average conversion price of $.46 per share.

        All share and per share  information  regarding  the  Company's  Class A
Common Stock  contained  herein is before giving effect to the proposed  Reverse
Split.  If the Reverse  Split is  implemented,  all such share  numbers would be
divided  by the  Exchange  Number  and all  such  per  share  amounts  would  be
multiplied by the Exchange Number.
    

Purpose of the Additional Issuance Proposal

        The rules of Nasdaq  require  companies,  the stocks of which are quoted
thereon, to obtain stockholder approval prior to issuing, in a transaction other
than in a public  offering,  a number of shares of common  stock equal to 20% or
more of its common  stock or voting power  outstanding  before the issuance at a
price less than the greater of the book or market value of the stock.

   
        To meet this requirement,  the Company and the Investors agreed that, in
the event the Company would be required to issue more than  4,000,000  shares of
its  Class  A  Common  Stock  upon  conversion  of all of  the  Debentures  (the
"Conversion Limit"), the Company will have the option of: (i) issuing additional
shares  of Common  Stock  but only if (x)  stockholder  approval  (being  sought
herein) has been  obtained or  stockholder  approval is not required in order to
comply with  applicable  rules of the market upon which its Class A Common Stock
is traded and (y) the  additional  shares are  registered  for resale  under the
Securities Act or (ii) paying cash
    

                                       -8-
<PAGE>



   
to the Investors in an amount equal to the principal  amount of Debentures being
converted  plus an amount  equal to the number of shares of Class A Common Stock
that would be otherwise issuable upon conversion of the Debentures multiplied by
the difference  between the highest sales price of the Company's Common Stock on
the date of conversion and the applicable Debenture conversion price.

        The purpose of the Additional Issuance Proposal is to enable the Company
(upon  registering  such additional  shares under the Securities Act) to utilize
its option to issue  additional  shares of Class A Common Stock  (limited by the
number of  shares,  in excess of  outstanding  shares and  shares  reserved  for
issuance,  which the Company is  authorized  to issue under its  Certificate  of
Incorporation)  upon conversion of the Debentures should the Conversion Limit be
reached,  thus enabling the Company to utilize its available cash for operations
and to develop products.

        Assuming (a) the maximum  principal  amount of Debentures  are submitted
for  conversion  during  each  period  they are  permitted  to be  tendered  for
conversion and (b)  conversion  prices based upon the average of the closing bid
prices of the Company's Class A Common Stock during the five consecutive trading
days immediately  preceding  September 30, 1998 (except that conversions through
September 30, 1998 are based upon the actual  conversion price thereof),  if the
Additional  Issuance  Proposal is not adopted,  the Company would be required to
issue  3,815,476  shares of Class A Common  Stock (in  addition  to the  184,524
shares issued prior to September 30, 1998) and pay  $2,428,086 to the Investors.
Based on the same assumptions,  if the Additional  Issuance Proposal is adopted,
the  Company  could (to the  extent  it elects to issue  shares in excess of the
Conversion  Limit  and  assuming   continuation  of  such  market  price)  issue
approximately  5,976,092  shares  of  Class A  Common  Stock  in  excess  of the
Conversion  Limit,  but make no cash payments.  The foregoing share numbers will
vary  depending  upon  variations  in the market price of the  Company's  Common
Stock. While conversion,  as opposed to redemption, of the Debentures will serve
to preserve the Company's cash and increase its net worth (facilitating  meeting
the $4 million  adjusted  tangible net assets  listing  maintenance  criteria of
Nasdaq),  the  issuance  of  significant  amounts of Class A Common  Stock could
adversely  affect the market  price of the  Company's  Class A Common Stock (and
adversely  effect  the  Company's  ability to meet the $1.00  minimum  bid price
listing maintenance criteria of Nasdaq).

        A vote against the Additional Issuance Proposal by stockholders will not
effect the rights of the Investors, who would, if the Company would otherwise be
required to issue shares in excess of the Conversion  Limit,  be able to require
the Company to redeem  Debentures  otherwise  convertible at a redemption  price
equal to, in effect,  that which the  Investors  could have received if they had
been able to  convert  the  Debentures  and,  at the time of their  election  to
convert the Debentures, sold the shares otherwise issuable to them.

Required Vote


        The affirmative  vote of a majority of the votes of Class A Common Stock
and Class B Common  Stock  present,  in person or by proxy,  at the  Meeting and
entitled to vote on this proposal,  voting  together as one class,  with Class A
Common Stock having one vote per share and Class B Common Stock having ten votes
per share,  will be  required  to adopt this  proposal.  The Board of  Directors
recommends that stockholders vote FOR approval of this proposal.
    


                                       -9-
<PAGE>


                                  MISCELLANEOUS

Stockholder Proposals

   
        From time to time stockholders may present proposals which may be proper
subjects for inclusion in the proxy statement and form of proxy relating to that
meeting. In order to be considered,  such proposals must be submitted in writing
on a  timely  basis.  Stockholder  proposals  intended  to be  included  in  the
Company's  proxy  statement  and form of proxy  relating to the  Company's  next
Annual Meeting of Stockholders must be received at 1375 Akron Street,  Copiague,
New  York  11726,  by  January  15,  1999.  Any such  proposals,  as well as any
questions relating thereto,  should be directed to the Secretary of the Company.
As to any proposals intended to be presented by a stockholder  without inclusion
in the Company's proxy statement and form of proxy for the Company's next Annual
Meeting,  the proxies named in the Company's form of proxy for that meeting will
be entitled to exercise  discretionary  authority  on that  proposal  unless the
Company receives notice of the matter on or before April 1, 1999. However,  even
if such notice is timely received,  such proxies may nevertheless be entitled to
exercise  discretionary  authority  on that  matter to the extent  permitted  by
Securities and Exchange Commission regulations.
    

Solicitation of Proxies

        The cost of  preparing,  assembling  and  mailing  the Notice of Special
Meeting,  this Proxy  Statement  and Proxies is to be borne by the Company.  The
Company will also reimburse  brokers who are holders of record of Class A Common
Stock for their expenses in forwarding Proxies and Proxy soliciting materials to
the  beneficial  owners of such  shares.  In  addition  to the use of the mails,
Proxies may be solicited without extra  compensation by directors,  officers and
employees  of  the  Company  by  telephone,   telecopy,  telegraph  or  personal
interview.  The Company has retained W.F.  Doring & Co.,  Inc.,  150 Bay Street,
Jersey City,  New Jersey 07302 to aid in the  solicitation  of Proxies.  For its
services,   W.F.  Doring  &  Co.,  Inc.  will  receive  a  fee  of  $2,500  plus
reimbursement for certain out-of-pocket expenses.

                                         By Order of the Board of Directors,


   
                                               /s/  Timothy J. Roach
                                                       Secretary
October 14, 1998
    




                                      -10-

<PAGE>


                                    Exhibit A


   
                  Article   4  of  the   Company's   Restated   Certificate   of
Incorporation  is to be  amended  to add the  following  immediately  after  the
present first  paragraph  thereof  (which sets forth the number and par value of
the Company's authorized capital stock, none of which is being amended):


                           "Effective 12:01 a.m. on , 19 (the "Effective Date"),
                  each ( ) shares of Class A Common  Stock then issued  shall be
                  automatically  combined into one share of Class A Common Stock
                  of the Corporation and each ( ) shares of Class B Common Stock
                  then issued shall be automatically  combined into one share of
                  Class B Common  Stock of the  Corporation.  There  shall be no
                  fractional shares issued. In lieu thereof,  each fraction of a
                  share  that  would  otherwise  be issued to  holders of record
                  thereof  shall be entitled  to receive a cash  payment in lieu
                  thereof  at a  price  equal  to  the  fraction  to  which  the
                  stockholder  would  otherwise  be entitled  multiplied  by the
                  closing price of the Class A Common Stock,  as reported in The
                  Wall  Street  Journal,  on the last  trading  day prior to the
                  Effective Date (or if such price is not available, the average
                  of the last bid and ask prices of the Class A Common  Stock on
                  such  day  or  other   price   determined   by  the  Board  of
                  Directors)."
    

<PAGE>



                       AMERICAN BIOGENETIC SCIENCES, INC.
          PROXY FOR SPECIAL MEETING OF STOCKHOLDERS - NOVEMBER 11, 1998

           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS



           The undersigned hereby appoints, as proxies for the undersigned, AIDA
PADILLA,  TIMOTHY J. ROACH and  LEONARD W.  SUROFF,  or any one or more of them,
with full  power of  substitution,  to vote all shares of the  capital  stock of
American  Biogenetic  Sciences,  Inc. (the  "Company")  which the undersigned is
entitled to vote at the  Special  Meeting of  Stockholders  of the Company to be
held on Wednesday,  November 11, 1998, at 10:30 a.m.  Eastern  Standard Time, at
the Huntington  Hilton,  598 Broad Hollow Road,  Melville,  New York, and at any
adjournments or  postponements  thereof,  receipt of Notice of which meeting and
the Proxy  Statement  accompanying  the same being  hereby  acknowledged  by the
undersigned,  upon the  matters  described  in the Notice of  Meeting  and Proxy
Statement  and upon such other  business as may properly come before the meeting
and any  adjournments  or  postponements  thereof,  hereby  revoking any proxies
heretofore given.

   
 x     PLEASE MARK AS IN THIS EXAMPLE
    

           A vote FOR each of Proposals 1 and 2 is  recommended  by the Board of
           Directors.

1.       To  authorize an Amendment to the  Company's  Restated  Certificate  of
         Incorporation  in order to effect a combination  (reverse split) of the
         Company's outstanding Class A Common Stock and Class B Common Stock.


                                    FOR           AGAINST         ABSTAIN

                                    [ ]           [ ]             [ ]




2.       To approve the  issuance of  additional  shares of Class A Common Stock
         upon conversion of the Company's 5% Convertible Debentures.


                                    FOR           AGAINST         ABSTAIN

                                    [ ]           [ ]             [ ]



   
                                    (continued and to be signed on reverse side)
    

<PAGE>


   
                           (continued from other side)
    

                  Each properly  executed proxy will be voted in accordance with
the  specifications  made on the reverse side hereof. If no  specifications  are
made, this proxy will be voted FOR each of Proposals 1 and 2.



                                         Dated:                      , 1998



                                              (SIGNATURE OF STOCKHOLDER)



                                              (SIGNATURE OF STOCKHOLDER)


                                        NOTE:  Please  sign  your  name or names
                                        exactly as set forth hereon. For jointly
                                        owned shares, each owner should sign. If
                                        signing    as    attorney,     executor,
                                        administrator,   trustee  or   guardian,
                                        please  indicate  the  capacity in which
                                        you  are  acting.  Proxies  executed  by
                                        corporations  should be signed by a duly
                                        authorized  officer  and should bear the
                                        corporate seal.


              PLEASE DATE AND SIGN THIS PROXY AND MAIL IT PROMPTLY
           IN THE ENCLOSED ENVELOPE. NO POSTAGE IS REQUIRED IF MAILED
                              IN THE UNITED STATES.




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