AMERICAN BIOGENETIC SCIENCES INC
DEF 14A, 1998-05-15
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                            SCHEDULE 1A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Filed by the Registrant [X]

Filed by a party other than the Registrant [_]

Check the appropriate box:

[_]   Preliminary Proxy Statement
[_]   Confidential,  for  Use of the  Commission  Only  (as  permitted  by  Rule
      14a-6(e)(2))
[X]   Definitive Proxy Statement
[_]   Definitive Additional Materials
[_]   Soliciting Material Pursuant to ss.240.14a-11(c) or ss.240.14a-12

                       American Biogenetic Sciences, Inc.
                       ----------------------------------
                (Name of Registrant as Specified in Its Charter)


            ---------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[X]   No fee required

[_]   Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11

      1)    Title of each class of securities to which transaction applies:

      2)    Aggregate number of securities to which transaction applies:

      3)    Per unit price or other  underlying  value of  transaction  computed
            pursuant  to  Exchange  Act Rule 0-11 (Set forth the amount on which
            the filing fee is calculated and state how it was determined):

      4)    Proposed maximum aggregate value of transaction:

      5)    Total fee paid:

[_]   Fee paid previously with preliminary materials.

[_]   Check box if any part of the fee is offset as  provided  by  Exchange  Act
      Rule  0-11(a)(2)  and identify the filing for which the offsetting fee was
      paid  previously.  Identify the previous filing by registration  statement
      number, or the Form or Schedule and the date of its filing.

      1)    Amount Previously Paid:

      2)    Form, Schedule or Registration Statement No.:

      3)    Filing Party:

      4)    Date Filed:


<PAGE>



                       AMERICAN BIOGENETIC SCIENCES, INC.

                                1375 AKRON STREET
                            COPIAGUE, NEW YORK 11726
                              --------------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                              --------------------

                                  June 18, 1998
                              --------------------

            NOTICE IS HEREBY GIVEN that the 1998 Annual Meeting of  Stockholders
of American Biogenetic  Sciences,  Inc., a Delaware corporation (the "Company"),
will  be  held  at  Boston   University,   595  Commonwealth   Avenue,   Boston,
Massachusetts, on Thursday, June 18, 1998 at 3:00 p.m., Eastern Daylight Savings
Time.  The  following  matters  are to be  presented  for  consideration  at the
meeting:

                  1. The  election  of seven  directors  to serve until the next
            annual meeting of stockholders and until their respective successors
            are elected and qualified;

                  2. A proposal to approve an  amendment to the  Company's  1996
            Stock Option Plan to increase the number of shares of Class A Common
            Stock which may be issued  thereunder  from  1,000,000  to 2,000,000
            shares;

                  3. A proposal to ratify the  selection of Arthur  Andersen LLP
            as the Company's  independent  auditors for the year ending December
            31, 1998; and

                  4. The transaction of such other business as may properly come
            before the meeting or any adjournments or postponements thereof.

            The close of business on April 20, 1998 has been fixed as the record
date for the  determination  of stockholders  entitled to notice of, and to vote
at, the meeting and any  adjournments or postponements  thereof.  A list of such
stockholders  will be open for  examination by any  stockholder  for any purpose
germane to the meeting, during ordinary business hours, for a period of at least
ten days prior to the meeting at the Boston  offices of the Company,  801 Albany
Street, Boston, Massachusetts.

                                             By Order of the Board of Directors,

                                                    Timothy J. Roach
                                                       Secretary


Copiague, New York
May 15, 1998

WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING,  PLEASE COMPLETE, DATE AND SIGN
THE  ENCLOSED  PROXY AND MAIL IT PROMPTLY IN THE  ENCLOSED  ENVELOPE IN ORDER TO
ASSURE  REPRESENTATION  OF YOUR  SHARES.  NO  POSTAGE IS NEEDED IF MAILED IN THE
UNITED STATES.



<PAGE>



                       AMERICAN BIOGENETIC SCIENCES, INC.

                                1375 Akron Street
                            Copiague, New York 11726

                              --------------------

                                 PROXY STATEMENT
                              --------------------

            This Proxy  Statement  is furnished to the holders of Class A Common
Stock  ("Class A Common  Stock") and to the sole holder of Class B Common  Stock
("Class B Common Stock") of American Biogenetic  Sciences,  Inc. (the "Company")
in connection with the  solicitation by the Board of Directors of the Company of
proxies in the  accompanying  form ("Proxy" or "Proxies") to be used at the 1998
Annual  Meeting of  Stockholders  of the Company (the  "Meeting")  to be held on
Thursday,  June 18, 1998, at 3:00 p.m., Eastern Daylight Savings Time, at Boston
University,  595  Commonwealth  Avenue,  Boston,   Massachusetts,   and  at  any
adjournments  and  postponements  thereof,  for the  purposes  set  forth in the
accompanying  Notice of  Annual  Meeting.  It is  anticipated  that  this  Proxy
Statement  and the Proxies  will be mailed to  stockholders  on or about May 15,
1998.  The cost of  preparing,  assembling  and  mailing  the  Notice  of Annual
Meeting,  this Proxy  Statement  and Proxies is to be borne by the Company.  The
Company will also reimburse  brokers who are holders of record of Class A Common
Stock for their expenses in forwarding Proxies and Proxy soliciting materials to
the  beneficial  owners of such  shares.  In  addition  to the use of the mails,
Proxies may be solicited without extra  compensation by directors,  officers and
employees  of  the  Company  by  telephone,   telecopy,  telegraph  or  personal
interview.  Proxies properly  executed and received in time for the Meeting will
be voted. A stockholder who signs and returns a Proxy has the power to revoke it
at any time before it is exercised by giving written notice of revocation to the
Company, 1375 Akron Street, Copiague, New York 11726, Attention: Secretary, by a
duly executed proxy of later date, or by voting in person at the Meeting.

            The close of business on April 20, 1998 has been fixed as the record
date for the  determination  of stockholders  entitled to notice of, and to vote
at, the Meeting (the "Record Date"). There were outstanding,  as of the close of
business on that date,  19,635,645  shares of Class A Common Stock and 1,725,500
shares of Class B Common  Stock.  A  majority  of the total of such  outstanding
shares of Class A Common Stock and Class B Common Stock,  represented  in person
or by  Proxy  at the  Meeting,  is  required  to  constitute  a  quorum  for the
transaction of business at the Meeting. Holders of Class A Common Stock have one
vote for each  share  thereof  held of record  and the  holder of Class B Common
Stock has ten votes for each share  thereof  held of record.  The Class A Common
Stock and Class B Common  Stock will vote as one class on all  matters  proposed
herein to be submitted to stockholders at the Meeting.  Proxies  submitted which
contain  abstentions or broker nonvotes will be deemed present at the Meeting in
determining the presence of a quorum. Shares subject to abstentions with respect
to any matter are considered shares entitled to, and voted, with respect to that
matter.  Shares  subject to broker  nonvotes  with respect to any matter are not
considered  as shares  entitled to vote with respect to that matter.  Therefore,
abstentions  will, in effect,  be deemed  negative votes on each  proposal,  but
broker  nonvotes  will not affect the  results  of any of the  matters  proposed
herein to be submitted to stockholders at the Meeting.

            Unless otherwise  specified,  all Proxies received will be voted for
the election of all nominees  named  herein to serve as  directors,  in favor of
approval of the  amendment to the  Company's  1996 Stock Option Plan to increase
the number of shares of Class A Common Stock which may be issued thereunder, and
to ratify the  selection  of Arthur  Andersen LLP as the  Company's  independent
auditors. The Board of Directors does not intend to bring before the Meeting any
matter  other than those  specifically  described  above and knows of no matters
other than the  foregoing  to come before the Meeting.  If any other  matters or
motions come before the Meeting, it is the intention of the persons named in the
accompanying  Proxy to vote such Proxy in accordance with their judgment on such
matters or  motions,  including  any  matters  dealing  with the  conduct of the
Meeting.



<PAGE>



                          SECURITY HOLDINGS OF CERTAIN
                      STOCKHOLDERS, MANAGEMENT AND NOMINEES

            The  following  table sets forth  information  as at the Record Date
with respect to the beneficial  ownership of the Company's  Class A Common Stock
and Class B Common Stock by (i) each person known by the Company to beneficially
own more than 5% of the  outstanding  shares of Class A Common  Stock or Class B
Common Stock,  (ii) each director of the Company,  (iii) each executive  officer
named  in  the  Summary   Compensation   Table  under  the  caption   "Executive
Compensation" and (iv) all executive  officers and directors of the Company as a
group.  Each  share of Class A Common  Stock is  entitled  to one vote per share
while each share of Class B Common Stock is entitled to ten votes per share. The
Company  understands that, except as noted below, each beneficial owner has sole
voting and  investment  power with  respect to all shares  attributable  to such
owner.

                            Class A Common Stock(1)        Class B Common Stock
                            -----------------------        --------------------
                                             Percent                    Percent
Beneficial Owner            No. Shares       of Class      No. Shares   of Class
- -----------------          ------------      --------      ----------   --------
                                                       
Alfred J. Roach(2)           3,668,750(2)       16.3%       1,725,500    100%

Stephen H. Ip                   71,668(3)        *               --       --
                                                
Ellena M. Byrne                200,000(3)(4)     1.0%            --       --
                                                
Timothy J. Roach               595,000(3)        2.9%            --       --
                                                
Gustav V. R. Born               20,000(3)        *               --       --
                                                
Joseph C. Hogan                 50,000(3)        *               --       --
                                                
William G. Sharwell             55,000(3)        *               --       --
                                               
All executive officers
 and directors as a group
 (10 persons, including
  the foregoing)             4,930,918(5)       20.8%       1,725,500    100%

- ---------------------------                 
(1)   Asterisk  indicates less than one percent.  Shares of Class A Common Stock
      subject to issuance  upon  conversion of Class B Common Stock into Class A
      Common  Stock and upon  exercise of options that were  exercisable  on, or
      become  exercisable  within 60 days after,  the Record Date are considered
      owned by the holder thereof and  outstanding for purposes of computing the
      percentage of outstanding Class A Common Stock that would be owned by such
      person,  but (except for the  computation  of beneficial  ownership by all
      executive   officers  and  directors  as  a  group)  are  not   considered
      outstanding for purposes of computing the percentage of outstanding  Class
      A Common Stock owned by any other person.

(2)   The address of Mr.  Roach is Route 2 - Kennedy  Avenue,  Guaynabo,  Puerto
      Rico  00657.  Beneficial  ownership  of  Class  A  Common  Stock  includes
      1,725,500  shares of Class A Common Stock issuable upon  conversion of the
      same  number of shares of Class B Common  Stock on a share for share basis
      and  1,160,000  shares  of Class A Common  Stock  subject  to  outstanding
      options.

                                              (Footnotes continued on next page)



                                       -2-

<PAGE>



(3)   Includes  shares of Class A Common  Stock  subject to options as  follows:
      Stephen H. Ip, 66,668;  Ellena M. Byrne,  165,000 (including 10,000 shares
      subject to options held by her husband); Timothy J. Roach, 595,000; Gustav
      V.R.  Born,  20,000;  Joseph C. Hogan,  40,000;  and William G.  Sharwell,
      45,000.

(4)   Includes  10,000  shares owned by Ms.  Byrne's son. The inclusion of these
      amounts  should not be  construed  as an  admission  that Ms. Byrne is the
      beneficial owner of these shares.

(5)   Includes 1,725,500 shares of Class A Common Stock issuable upon conversion
      of the same number of shares of Class B Common Stock and 2,336,668  shares
      of Class A Common Stock subject to outstanding options.


                                   PROPOSAL 1.

                              ELECTION OF DIRECTORS

            The  Company's  By-Laws  provide  that the  number of members of the
Board of  Directors  shall be not less than three or more than  nine,  the exact
number  to be fixed  by  resolution  of the  Board of  Directors.  The  Board of
Directors presently consists of seven members. Each of the nominees,  other than
Stephen H. Ip (who was elected as a director by the Board in January 1998),  has
been previously elected by stockholders of the Company.

            Unless authority to do so is withheld,  Proxies will be voted at the
Meeting  for the  election  of each of the  nominees  named  below  to  serve as
directors of the Company until the next annual meeting of stockholders and until
their respective successors are elected and qualified.  In the event that any of
the nominees  should become  unavailable or unable to serve for any reason,  the
holders  of  Proxies  have  discretionary  authority  to  vote  for  one or more
alternate  nominees  designated by the Board of Directors.  The Company believes
that all of the nominees are available to serve as directors.

BACKGROUND OF NOMINEES

            Alfred J. Roach,  82, has been Chairman of the Board of Directors of
the Company since its  organization  in September  1983 and, from September 1983
until  October  1988,  also served as President  of the  Company.  Mr. Roach has
served as  Chairman  of the  Board  and/or  President  of TII  Industries,  Inc.
("TII"), a corporation engaged in manufacturing and marketing telecommunications
products,  and its  predecessor  since its founding in 1964. Mr. Roach devotes a
majority of his time to the business of the Company.

            Stephen H. Ip,  Ph.D.,  51,  joined the  Company in January  1997 as
Executive Vice President and Chief Operating  Officer and was elected  President
and a director, in addition to continuing as Chief Operating Officer, in January
1998. Prior to joining the Company,  Dr. Ip served as Vice President,  Corporate
and Business Development of Paracelsian,  Inc., a publicly-held  company engaged
in  clinical  and  pre-clinical  development  of drugs and  supplements  for the
treatment of AIDS and cancer,  from February,  1996. From 1990 through  December
1995,  Dr. Ip served as  President,  Chief  Operating  Officer  and  director of
CytoMed,  Inc.,  a  biopharmaceutical   company  engaged  in  the  research  and
development  of  synthetic  chemical  drugs  and  recombinant  proteins  for the
treatment of acute and chronic  diseases.  From 1984 through  1989,  he was Vice
President and a scientific co-founder of T Cell Sciences,  Inc., a biotechnology
company.

            Ellena  M.  Byrne,  47,  has been  Executive  Vice  President  and a
director of the Company since March 1995. From January 1986 until December 1991,
Ms.  Byrne  served as Vice  President-Administration  of the Company  and,  from
December 1991 until March 1995, Ms. Byrne served in various  capacities with the
Company, including Director of Operations for Europe and Asia.




                                       -3-

<PAGE>




            Timothy J. Roach,  51, has been Treasurer,  Secretary and a director
of the Company since  September 1983. He has also been affiliated with TII since
1974,  serving as its President since July 1980,  Chief Operating  Officer since
May 1987, Vice Chairman of the Board since October 1993, Chief Executive Officer
since January 1995 and a director  since  January  1978.  Mr. Roach devotes such
time as is necessary  to the business of the Company to discharge  his duties as
Treasurer,  Secretary  and a director.  Timothy J. Roach is the son of Alfred J.
Roach.

            Gustav Victor Rudolf Born,  M.D.,  D.Phil.,  F.R.S.,  76, has been a
director of the  Company  since  January  1997.  Since  1988,  Dr. Born has been
Research Director of The William Harvey Research Institute at St.  Bartholomew's
Hospital Medical College, London, England and Emeritus Professor of Pharmacology
in the University of London.  Among Dr. Born's  distinctions,  appointments  and
activities are: Fellowship and Royal Medal of the Royal Society;  and Foundation
President of the British Society for Thrombosis and Haemostasis.

            Joseph C. Hogan, Ph.D., 75, has been a director of the Company since
December  1983.  Dr. Hogan served as Dean of the College of  Engineering  of the
University of Notre Dame from 1967 to 1981, following which he performed various
services  for the  University  of Notre Dame until 1985,  where he remains  Dean
Emeritus.  From 1985 until his  retirement  in 1987,  Dr.  Hogan was Director of
Engineering Research and Resource Development at Georgia Institute of Technology
("Georgia Tech"). Dr. Hogan is a director of TII.

            William G. Sharwell,  D.C.S., 77, has been a director of the Company
since October 1986.  Dr.  Sharwell was President of Pace  University in New York
from 1984 until his retirement in 1990. He was Senior Vice President of American
Telephone & Telegraph  Company  between 1976 and 1984, and previously  served as
Executive  Vice  President of  Operations  of New York  Telephone  Company.  Dr.
Sharwell  serves on the Board of Directors of TII and as an independent  general
partner of Equitable  Capital  Partners,  L.P. and  Equitable  Capital  Partners
(Retirement Fund), L.P.,  registered  investment  companies under the Investment
Company Act of 1940.

MEETINGS OF THE BOARD OF DIRECTORS

            During the year ended December 31, 1997, the Board of Directors held
two meetings and acted by unanimous  written consent on ten occasions  following
informal  discussions.  Each  director was present at all of the meetings of the
Board of Directors and  committees  of the Board on which such  director  served
that were held  during  the  period in 1997 such  person  served as a  director,
except  that Dr.  Born was not  present  at one of the two Board  meetings  held
during 1997.

COMMITTEES OF THE BOARD OF DIRECTORS

            The Board of Directors has an Audit and Compensation Committee,  but
does not have a nominating committee.

            The Audit Committee,  which consists of Messrs.  Hogan and Sharwell,
is  authorized  to  examine  and  consider  matters  related to the audit of the
Company's accounts, the financial affairs and accounts of the Company, the scope
of the independent  auditors'  engagement and their compensation,  the effect on
the Company's financial statements of any proposed changes in generally accepted
accounting principles,  disagreements, if any, between the Company's independent
auditors  and  management,  and matters of concern to the  independent  auditors
resulting  from the audit,  including the results of the  independent  auditors'
review of internal  accounting  controls.  This committee is also  authorized to
nominate  independent  auditors,  subject to approval by the Board of Directors.
The Audit Committee held two meetings during 1997.



                                       -4-

<PAGE>



            The  Compensation  Committee is authorized to consider and recommend
to  the  Board  of  Directors  the  salaries,  bonuses  and  other  compensation
arrangements  with  respect  to the  executive  officers  of the  Company.  This
Committee is also  empowered to grant all options  under,  and  administer,  the
Company's stock option plans. The Compensation Committee is further empowered to
examine,  administer and make  recommendations to the full Board with respect to
other employee benefit plans and  arrangements of the Company.  The Compensation
Committee presently consists of Messrs. Joseph C. Hogan and William G. Sharwell.
The  Compensation  Committee  acted  by  unanimous  written  consent  on  twelve
occasions during 1997 following informal discussions.

REMUNERATION OF DIRECTORS

            Directors  receive no  compensation  for service on the Board.  Each
director serving on the Audit Committee  receives a fee of $600 for each meeting
of the committee attended by that director in person and not telephonically. All
directors are reimbursed  for travel  expenses  incurred in attending  Board and
committee meetings.

            The Company's 1993 Non-Employee Director Stock Option Plan, approved
by stockholders at the Company's 1993 Annual Meeting of  Stockholders,  provides
for the automatic  grant of an option to purchase 10,000 shares of the Company's
Class A Common Stock to each  non-employee  director holding office  immediately
after each annual meeting of stockholders. The exercise price for each option is
equal to the fair market value of the Company's Class A Common Stock on the date
of  grant.  All  options  have a term of five  years and are  exercisable,  on a
cumulative  basis, at the rate of one quarter of the number of shares subject to
the option in each year commencing one year after the date of the grant.

            See  "Executive   Compensation"   for  information   concerning  the
compensation  of Mr. Alfred J. Roach and Dr. Stephen H. Ip for their services as
executive officers of the Company.  The Company is also a party to an employment
agreement dated October 1, 1996 with Ms. Ellena M. Byrne,  pursuant to which Ms.
Byrne is serving as Executive  Vice  President of the  Company.  The  Employment
Agreement  provides  for  a  term  extending,   subject  to  certain  terms  and
conditions,  until September 30, 2001. Ms. Byrne's current annual salary is U.S.
$18,200 and (pound)50,000 Irish Pounds  (approximately U.S. $68,000 at March 31,
1998).  Dr.  Born  serves as a  consultant  to the Company for which he receives
compensation at the rate of $12,000 per annum.

REQUIRED VOTE

            A plurality of the votes cast at the Meeting by the holders of Class
A Common Stock and Class B Common Stock voting together as one class, with Class
A Common  Stock  having one vote per share and Class B Common  Stock  having ten
votes per share,  will be required for the election of  directors.  The Board of
Directors recommends that stockholders vote FOR each of Alfred J. Roach, Stephen
H. Ip, Ellena M. Byrne,  Timothy J. Roach, Gustav V.R. Born, Joseph C. Hogan and
William G. Sharwell to serve as directors of the Company.

                               EXECUTIVE OFFICERS

            The  executive  officers  of the  Company,  in addition to Alfred J.
Roach,  Stephen H. Ip,  Timothy J. Roach and Ellena M. Byrne (whose  backgrounds
are described under the caption "Election of Directors - Background of Nominees"
above), are:

            Emer Leahy,  Ph.D.,  32,  rejoined  the  Company in  December  1997,
serving  as Senior  Vice  President-  Business  Development.  From April 1995 to
December  1997,  Dr.  Leahy was  employed by AMBI,  Inc.,  a  biotechnology  and
nutraceutical    company,    as   Vice    President-Product    Development   and
Director-Business  Development, where she coordinated licensing technologies and
products as well as participating in corporate acquisitions.  From April 1994 to
April 1995, Dr. Leahy was Vice President-Neuroscience and, from August



                                       -5-

<PAGE>



1993 to April 1994, was Vice  President-Regulatory  Affairs of the Company. From
February 1992 until August 1993, Dr. Leahy was employed by Boehringer Ingelheim,
GmbH, a multinational  pharmaceutical  company,  where she coordinated  clinical
trials in Ireland. In addition,  from October 1991 to August 1993, Dr. Leahy was
lecturer in Pharmacology at the Royal College of Surgeons of Ireland.

            James H.  McLinden,  Ph.D.,  47, has been Vice President - Molecular
Biology of the Company since November 1991. Prior thereto (and since joining the
Company in January 1987),  Dr. McLinden served as Director of Molecular  Biology
of the Company.

            Josef  C.  Schoell,  48,  joined  the  Company  in July  1992 as its
Controller and was elected Vice President-  Finance and Chief Financial  Officer
of the Company in July 1995. Mr. Schoell is a Certified Public Accountant in the
State of New York.

                             EXECUTIVE COMPENSATION

SUMMARY COMPENSATION TABLE

            The following table sets forth information concerning the annual and
long-term  compensation  for services in all  capacities  to the Company  during
1995, 1996 and 1997 of the Company's  chief executive  officer and the executive
officers  of the  Company  whose  annual  cash  compensation  for 1997  exceeded
$100,000:

                                                    ANNUAL          LONG-TERM
                                                 COMPENSATION      COMPENSATION
  NAME AND                                     -----------------   ------------
  PRINCIPAL POSITION                   YEAR    SALARY      BONUS     OPTIONS
  ------------------                   ----    -----------------     -------
                       
Alfred J. Roach, Chairman              1997   $250,000       --         --
  of the Board and Chief               1996   $250,000       --         --
  Executive Officer                    1995   $250,000       --      135,000

Stephen H. Ip, Executive Vice          1997   $146,000   $ 25,000    200,000
  President and Chief Operating
  Officer (1)

Josef C. Schoell, Vice President-      1997   $103,000       --       25,000
  Finance                              1996   $ 95,000       --       10,000
                                       1995   $ 76,000       --       60,000

Paul E. Gargan, Former President       1997   $137,000       --         --
                                       1996   $162,000       --         --
                                       1995   $150,000       --       31,500

- --------------------

(1)   Dr. Ip joined the Company in January 1997 and was elected President of the
      Company in January 1998.





                                       -6-

<PAGE>



OPTION GRANTS IN LAST FISCAL YEAR

           The  following  table  contains  information  concerning  options  to
purchase shares of the Company's capital stock granted by the Company during the
year ended  December  31, 1997 to the  executive  officers  named in the Summary
Compensation  Table.  No stock  appreciation  rights  have been  granted  by the
Company.

<TABLE>
<CAPTION>
                                         INDIVIDUAL OPTIONS                    POTENTIAL
                   -------------------------------------------------------     REALIZABLE VALUE
                                 PERCENT                                       AT ASSUMED ANNUAL
                   NUMBER OF     OF TOTAL                                      RATES OF STOCK
                   SHARES        OPTIONS                                       PRICE APPRECIATION
                   UNDERLYING    GRANTED TO     EXERCISE                       FOR OPTION TERM (2)
                   OPTIONS       EMPLOYEES IN   PRICE          EXPIRATION      -------------------
  NAME             GRANTED(1)    FISCAL YEAR    PER SHARE(1)   DATE             5%            10%
  ----             ----------    -----------    ------------   -----------     ----          ----
<S>                  <C>             <C>          <C>            <C>  <C>    <C>          <C>       
Stephen H. Ip        200,000         21.8%        $3.66          1/02/2007   $460,351     $1,166,619
                    
Josef C. Schoell      25,000          2.7%        $3.47          1/20/2007   $ 54,557     $  138,257
</TABLE>
- -------------             
(1)   Exercisable  as to 25% of the  number of  shares  of Class A Common  Stock
      underlying the option  commencing six months after the date of grant, on a
      cumulative  basis.  The exercise  price of each of the options  granted to
      Messrs.  Ip and Schoell is the market value of the Class A Common Stock on
      the date of grant.

(2)   These  are  hypothetical   values  using  assumed  compound  growth  rates
      prescribed by the Securities and Exchange  Commission and are not intended
      to forecast possible future  appreciation,  if any, in the market price of
      the Company's Class A Common Stock.

OPTION EXERCISES IN LAST FISCAL YEAR AND YEAR-END VALUES

            No options to purchase  shares of the  Company's  capital stock were
exercised   during  1997  by  the  executive   officers  named  in  the  Summary
Compensation  Table.  The following  table contains  information  concerning the
number of shares of Class A Common Stock underlying  unexercised options held at
December 31, 1997 by the executive  officers  named in the Summary  Compensation
Table.

                                 VALUE OF                   VALUE OF
                                 NUMBER OF                  UNEXERCISED
                                 UNEXERCISED                IN-THE-MONEY
                                 OPTIONS HELD AT            OPTIONS HELD AT
                                 FISCAL YEAR-END (#)        FISCAL YEAR-END($)
                                 (EXERCISABLE/              (EXERCISABLE/
              NAME               UNEXERCISABLE)             UNEXERCISABLE(1)
              ----               -------------------        ----------------
          Alfred J. Roach          1,160,000/    0          $      0/$    0
          Stephen H. Ip                  0  /200,000        $      0/$    0
          Josef C. Schoell            95,000/130,000        $  9,375/$    0
          Paul E. Gargan(2)          164,000/    0          $  4,922/$    0
- --------------

(1)   The closing price of the  Company's  Class A Common Stock The Nasdaq Stock
      Market's  National  Market on December 31, 1997 less the exercise price of
      each option.

(2)   Excludes options held by Dr. Gargan's wife.



                                       -7-

<PAGE>



EMPLOYMENT AGREEMENTs

            The Company is a party to an employment  agreement  with Dr. Stephen
H. Ip, dated  December  16, 1996,  under which Dr. Ip is serving as President of
the Company.  The agreement provides for a term expiring December 31, 1999, with
the Company and Dr. Ip having the right to terminate the agreement without cause
on thirty and sixty days' notice,  respectively.  In the event of termination of
the agreement by the Company without cause,  Dr. Ip is to remain as a consultant
to the  Company  at his then  existing  compensation  for a period  of one year,
provided that the consulting and compensation arrangement is to terminate if Dr.
Ip enters into full-time employment with a third party. Under the agreement, Dr.
Ip's current  annual  salary is $175,000  per annum.  Dr. Ip recieved a one-time
$25,000 bonus in connection with his entering into the agreement and is entitled
to an annual  bonus of up to 20% of his annual  salary  based on goals  mutually
agreed upon between the Company and Dr. Ip.

            The Company is also a party to an employment agreement with Dr. Emer
Leahy,  dated November 12, 1997, under which Dr. Leahy is serving as Senior Vice
President-Business Development of the Company. The agreement provides for a term
expiring  November 30, 2001.  Under the agreement,  Dr.  Leahy's  current annual
salary is $150,000 per annum. Dr. Leahy is entitled to annual bonuses and salary
increases based upon performance,  as well as reimbursement for tuition fees for
an Executive MBA program.

            As part of their respective employment agreements, Drs. Ip and Leahy
have agreed not to disclose confidential information about the Company during or
after  employment  and not to  compete  with the  Company  during  their term of
employment and, in certain instances, following employment.

REPORT OF COMPENSATION COMMITTEE CONCERNING EXECUTIVE COMPENSATION

            The Compensation Committee of the Board of Directors,  consisting of
Messrs.  Joseph C. Hogan and  William  G.  Sharwell,  "non-employee"  directors,
within the meaning of Rule 16b-3  promulgated  by the  Securities  and  Exchange
Commission under the Securities  Exchange Act of 1934, and "outside  directors",
within the meaning of Section  162(m) of the Internal  Revenue Code of 1986,  as
amended ("Section 162(m)"), is authorized to consider and recommend to the Board
of Directors salaries, bonuses and other compensation arrangements for executive
officers and to grant all options under, and administer,  the Company's employee
stock option plans.

            The  Compensation   Committee  believes  that  the  Company,   as  a
development stage company,  should create  compensation  packages to attract and
retain  executives  who can  bring the  experience  and  skills  to the  Company
necessary for the  development of the Company and  development  and marketing of
its products.  To date, this has been  accomplished  by utilizing  salary as the
base compensation and stock options to promote long-term  incentives and, in one
case, a bonus as an  inducement  to an  executive  to join the  Company.  As the
Company grows, other forms of annual and long-term compensation arrangements may
be  developed  to  provide   appropriate   incentives  and  to  reward  specific
accomplishments.

            In determining base salaries,  the Compensation  Committee examines,
among other factors, the executive's  performance,  degree of responsibility and
experience,  as well as general employment conditions,  competition and economic
factors.  No specific weights are assigned to any of the factors employed by the
Compensation Committee. In 1997, the salaries of certain executive officers were
increased, using subjective standards, to recognize their performance.

            The  Compensation  Committee  also  makes  use of stock  options  to
provide  long-term  incentive  compensation to many of the Company's  employees,
including executive officers, enabling them to benefit, along



                                       -8-

<PAGE>



with all  stockholders,  if the market price for Class A Common Stock rises. The
Compensation  Committee  believes  that the use of stock  options ties  employee
interests to those of the Company's  stockholders  through  stock  ownership and
potential  stock  ownership,  while also  providing  the Company with a means of
compensating  employees using a method which enables the Company to conserve its
available cash for operations and product  development.  To assure the long-term
nature of the incentive,  options granted have generally not become  exercisable
during the first year after grant and thereafter have become  exercisable over a
period of two to four  years.  Decisions  of the  Compensation  Committee  as to
option grants are based, in large measure,  upon a review of such factors as the
executive's level of responsibility,  other  compensation,  accomplishments  and
goals,  and when the last  option  was  granted  to such  executive,  as well as
recommendations  and evaluations of the executive's  performance and prospective
contributions by the Company's Chief Executive Officer. Determinations have been
made subjectively without giving weight to specific factors.

            Chief Executive Officer Compensation. The salary of Alfred J. Roach,
the Company's Chief Executive  Officer has remained  unchanged for the past five
years, although he was granted options to purchase shares of the Company's Class
A Common  Stock  during  1995  under the  Company's  1986 Stock  Option  Plan in
recognition of his efforts on behalf of the Company.  No options were granted to
Mr. Roach in 1996 or 1997.

            Certain Tax  Legislation.  Section 162(m) precludes a public company
from taking a federal income tax deduction for annual  compensation in excess of
$1,000,000  paid to its chief  executive  officer  or any of its four other most
highly compensated executive officers.  Certain "performance based compensation"
is excluded from the deduction limitation.  Any compensation  resulting from the
exercise  of stock  options  granted  by the  Company  should  be  eligible  for
exclusion since all options were either granted prior to the adoption of Section
162(m) or under a plan approved by the Company's stockholders which was designed
to  conform  to  regulations   for   determining   whether  options  are  deemed
"performance based compensation." The Committee believes that the limitations on
compensation  deductibility  under  Section  162(m)  will  have no effect on the
Company in the  foreseeable  future,  and  intends to take such action as may be
necessary, including obtaining stockholder approval where required, in order for
compensation  not to be subject to the  limitation on  deductibility  imposed by
Section 162(m) of the Code.


Respectfully submitted,


Joseph C. Hogan
William G. Sharwell





                                       -9-

<PAGE>





PERFORMANCE GRAPH

           The following graph compares the cumulative return to stockholders of
Class A Common  Stock  from  December  31,  1992 (the first  point  shown in the
following  graph) through December 31, 1997 with the Nasdaq Market Index and the
Dow Jones  Industry  Group BTC -  Biotechnology  Index for the same period.  The
comparison  assumes  $100 was  invested on  December  31, 1992 in Class A Common
Stock  and in  each  of the  comparison  groups,  and  assumes  reinvestment  of
dividends (the Company paid no dividends during the periods):




                               [GRAPHIC OMITTED]



- --------------------------------------------------------------------------------
At December 31,                          1992   1993   1994   1995   1996   1997
- --------------------------------------------------------------------------------
American Biogenetic Sciences              100     89     27     50     74     35
Peer Group Index                          100     94     83    144    149    160
NASDAQ Market Index                       100    120    126    163    203    248



SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

            Section 16(a) of the Securities  Exchange Act requires the Company's
executive officers and directors, and persons who beneficially own more than 10%
of the Company's Class A Common Stock, to file initial reports of ownership, and
reports of changes of ownership,  of the Company's  equity  securities  with the
Securities  and Exchange  Commission  and furnish copies of those reports to the
Company.  Based  solely on a review of copies of the  reports  furnished  to the
Company, or written  representation  that no reports were required,  the Company
believes  that all reports  required to be filed by such persons with respect to
the Company's year ended December 31, 1997 were timely filed.


                                      -10-

<PAGE>



                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

           On January 17, 1997,  November 26, 1997,  December 15, 1997, December
30,  1997 and May 4,  1998,  Mr.  Alfred J.  Roach  purchased  100,000,  50,000,
100,000,  100,000 and 50,000  shares,  respectively,  of the  Company's  Class B
Common Stock for $343,750, or $3.4375 per share; $109,375, or $2.1875 per share;
$168,800,  or $1.688 per share;  $156,250, or $1.5625 per share; and $81,250, or
$1.625 per share, respectively,  the closing bid prices of the Company's Class A
Common Stock (into which the Company's  Class B Common Stock is convertible on a
share-for-share  basis) on The  Nasdaq  Stock  Market's  National  Market on the
respective dates.

                                   PROPOSAL 2.

                 APPROVAL OF AN AMENDMENT OF THE COMPANY'S 1996
               STOCK OPTION PLAN TO INCREASE THE NUMBER OF SHARES
                   OF CLASS A COMMON STOCK ISSUABLE THEREUNDER

            At the  Company's  1996 annual  meeting,  stockholders  approved the
Company's  1996 Stock  Option  Plan (the  "Plan") to  provide  an  incentive  to
employees  of,  and  consultants  to, the  Company  and its  present  and future
subsidiaries and to offer an additional  inducement in obtaining the services of
such persons  through the grant of options to purchase  shares of the  Company's
Class A Common Stock  within the limits and subject to the terms and  conditions
of the Plan. The Plan is the only plan of the Company that presently permits the
grant of options to employees of, or consultants to, the Company.

            The Plan, as adopted,  presently  authorizes the grant of options to
purchase a maximum of 1,000,000  shares of Class A Common Stock. As of April 30,
1998, options to purchase an aggregate of 906,000 shares of Class A Common Stock
are outstanding, leaving only 94,000 shares (together with any shares subject to
options  which  become  available  for  grant in the  event  of any  expiration,
cancellation or termination of unexercised options) available for future grant.

            The Board of  Directors  believes  that the Plan serves the purposes
for which it was intended and has authorized an amendment to increase the number
of shares of Class A Common Stock  authorized  for issuance under the Plan by an
aggregate  of 1,000,000  shares  (subject to possible  adjustments  as described
below under "Adjustment in the Event of Capital Changes").

            The following summary of certain material features of the 1996 Plan.

SHARES SUBJECT TO THE OPTION PLAN AND ELIGIBILITY

            The Plan  authorizes  the grant of options to  purchase a maximum of
1,000,000  shares  (which will be increased to 2,000,000  shares if the proposed
amendment  to the  Plan is  approved  by  stockholders  at the  Meeting)  of the
Company's  Class A Common Stock  (subject to adjustment  as described  below) to
employees of, and to  consultants  to (including  officers and directors who are
employees  or  consultants),  the  Company  or  any of its  present  and  future
subsidiaries.  Upon  expiration,  cancellation  or  termination  of  unexercised
options,  the  shares of the  Company's  Class A Common  Stock  subject  to such
options will again be available for the grant of options under the Plan.



                                      -11-

<PAGE>



TYPE OF OPTIONS

            Options granted under the Plan may either be incentive stock options
("ISOs"),  within the meaning of Section  422 of the  Internal  Revenue  Code of
1986,  as amended (the  "Code"),  or  nonqualified  stock  options  which do not
qualify as ISOs ("NQSOs"). ISOs, however, may only be granted to employees.

ADMINISTRATION

            The Plan is to be  administered by the Board of Directors or, to the
extent the Board may  determine,  a  committee  of the Board  (the  "Committee")
consisting of at least two members of the Board, each of whom is a "non-employee
director"  within the  meaning of Rule 16b-3  promulgated  under the  Securities
Exchange Act of 1934, as amended (the "Exchange  Act"). It is also intended that
each member of the Committee will be an "outside director" within the meaning of
Section  162(m) of the Code.  The Plan is currently  being  administered  by the
Compensation  Committee of the Board.  References in the following discussion to
powers and actions that may be taken by the Committee include powers and actions
that may also be taken by the Board of Directors.

            Among other things, the Committee is empowered to determine,  within
any express limits  contained in the Plan,  the employees and  consultants to be
granted options,  whether an option granted to an employee is to be an ISO or an
NQSO, the number of shares of Class A Common Stock to be subject to each option,
the exercise price of each option, the term of each option, the date each option
shall  become  exercisable  as well as any  terms,  conditions  or  installments
relating to the exercisability of each option, whether to accelerate the date of
exercise of any option or  installment  and the form of payment of the  exercise
price, to construe each stock option contract  ("Contract")  between the Company
and an optionee and, with the consent of the optionee, to cancel (which could be
in  conjunction  with the grant of a new option at a lower  exercise price or on
different  terms and  conditions)  or modify an option.  The  Committee  is also
authorized to prescribe, amend and rescind rules and regulations relating to the
Plan and make all other determinations  necessary or advisable for administering
the Plan.

TERMS AND CONDITIONS OF OPTIONS

            Options  granted  under the Plan are subject to, among other things,
the following terms and conditions:

            (a)   The exercise  price of each option will be  determined  by the
Committee;  provided, however, that the exercise price of an ISO may not be less
than the fair market  value of the  Company's  Common Stock on the date of grant
(110% of such fair market value, in the case of an ISO, if the optionee owns (or
is deemed to own) more than 10% of the voting power of the Company).

            (b)   Options may be granted for terms  determined by the Committee;
provided, however, that the term of an ISO may not exceed ten years (five years,
in the case of an ISO, if the optionee  owns (or is deemed to own) more than 10%
of the voting power of the Company).

            (c)   The maximum  number of shares of the Company's  Class A Common
Stock for which  options may be granted to an employee in any  calendar  year is
150,000. In addition,  the aggregate fair market value of shares with respect to
which ISOs may be granted to an employee  under all option  plans of the Company
which are exercisable for the first time during any calendar year may not exceed
$100,000.

            (d)   The  exercise  price of each  option is  payable  in full upon
exercise or, if the applicable Contract permits, in installments. Payment of the
exercise price of an option may be made in cash, or, if the applicable  Contract
permits,  in shares of the  Company's  Class A Common  Stock or any  combination
thereof.



                                      -12-

<PAGE>



            (e)   Options  may not be  transferred  other than by will or by the
laws of descent and  distribution,  and may be exercised  during the  optionee's
lifetime only by the optionee.

            (f)   Except  as  may  otherwise  be  provided  in  the   applicable
Contract,  if the  optionee's  relationship  with the  Company as an employee or
consultant  is  terminated  for any reason other than death or  disability,  the
option may be exercised, to the extent exercisable at the time of termination of
such  relationship,  within three months  thereafter,  but in no event after the
expiration  of  the  term  of  the  option;  provided,   however,  that  if  the
relationship  is  terminated  either  for cause or  without  the  consent of the
Company,  the option will terminate  immediately.  Options are not affected by a
change in the status of an optionee so long as the  optionee  continues to be an
employee  of, or a consultant  to, the  Company.  In the case of the death of an
optionee  while an employee or consultant  (or,  generally,  within three months
after termination of such relationship,  or within one year after termination of
employment  by  reason  of  disability),  except as  otherwise  provided  in the
Contract,  the optionee's legal  representative  or beneficiary may exercise the
option,  to the extent  exercisable on the date of death,  within one year after
such date,  but in no event after the  expiration of the term of the option.  An
optionee  whose  relationship  with the  Company  is  terminated  by  reason  of
disability  may exercise the option,  to the extent  exercisable  at the time of
such  termination,  within one year thereafter,  but not after the expiration of
the term of the option.

            (g)   The Company may withhold  cash and/or  shares of the Company's
Class A Common  Stock  having an  aggregate  value equal to the amount which the
Company determines is necessary to meet its obligations to withhold any federal,
state  and/or local taxes or other  amounts  incurred by reasons of the grant or
exercise of an option or the disposition of shares acquired upon the exercise of
the option.  Alternatively,  the  Company  may  require the  optionee to pay the
Company such amount, in cash, promptly upon demand.

ADJUSTMENT IN EVENT OF CAPITAL CHANGES

            Appropriate  adjustments  will  be made in the  number  and  kind of
shares  available  under the Plan,  in the number and kind of shares  subject to
each outstanding option and the exercise prices of such options,  as well as the
limitation  on the number of shares  that may be granted to any  employee in any
calendar year, in the event of any change in the Company's  Class A Common Stock
by  reason  of any  stock  dividend,  split-up,  combination,  reclassification,
recapitalization,  spin-off,  merger in which the  Company is not the  surviving
corporation,  exchange of shares or the like. In the event of the liquidation or
dissolution  of the  Company,  or a  merger  in  which  the  Company  is not the
surviving  corporation  or  a  consolidation,   any  outstanding  options  shall
terminate  upon the earliest of any such event,  unless other  provision is made
therefor in the transaction.

DURATION AND AMENDMENT OF THE PLAN

            No option  may be  granted  under  the Plan  after  March 28,  2006.
However,  the Board of  Directors  may at any time  terminate or amend the Plan;
provided that, without the approval of the Company's stockholders,  no amendment
may be made which would (a) except as a result of the anti-dilution  adjustments
described  above,  increase the maximum number of shares available for the grant
of options or increase the maximum  number of shares covered by options that may
be granted to an employee in any  calendar  year,  (b)  materially  increase the
benefits  accruing to participants,  or (c) change the eligibility  requirements
for persons who may receive  options.  No termination or amendment may adversely
affect the rights of an optionee with respect to an  outstanding  option without
the optionee's consent.



                                      -13-

<PAGE>



FEDERAL INCOME TAX TREATMENT

            The  following  is a  general  summary  of the  federal  income  tax
consequences  under  current  tax law of NQSOs and ISOs.  It does not purport to
cover all of the  special  rules,  including  the  exercise  of an  option  with
previously-acquired   shares,  or  the  state  or  local  income  or  other  tax
consequences  inherent in the  ownership  and exercise of stock  options and the
ownership and disposition of the underlying shares.

            An optionee does not recognize taxable income for federal income tax
purposes upon the grant of a NQSO or an ISO.

            Upon the exercise of a NQSO, the optionee recognizes ordinary income
in an amount equal to the excess, if any, of the fair market value of the shares
acquired  on the date of  exercise  over the  exercise  price  thereof,  and the
Company  generally is entitled to a deduction  for such amount at that time.  If
the optionee later sells shares acquired  pursuant to the exercise of a NQSO, he
or she recognizes long-term or short-term capital gain or loss, depending on the
period  for which the shares  were held.  Long-term  capital  gain is  generally
subject to more  favorable  tax  treatment  than  ordinary  income or short-term
capital gain.

            Upon the exercise of an ISO, the optionee does not recognize taxable
income. If the optionee disposes of the shares acquired pursuant to the exercise
of an ISO more  than two  years  after  the date of grant and more than one year
after  the  transfer  of the  shares  to him or  her,  the  optionee  recognizes
long-term  capital  gain  or  loss  and  the  Company  is not be  entitled  to a
deduction.  However, if the optionee disposes of such shares within the required
holding  period,  all or a portion of the gain is treated as ordinary income and
the Company generally is entitled to deduct such amount.

            In addition to the federal income tax consequences  described above,
an optionee may be subject to the  alternative  minimum tax, which is payable to
the extent it exceeds the  optionee's  regular tax. For this  purpose,  upon the
exercise of an ISO,  the excess of the fair market  value of the shares over the
exercise price therefor is an adjustment  which  increases  alternative  minimum
taxable income. In addition, the optionee's basis in such shares is increased by
such excess for purposes of computing the gain or loss on the disposition of the
shares for alternative  minimum tax purposes.  If an optionee is required to pay
an  alternative  minimum  tax, the amount of such tax which is  attributable  to
deferral  preferences  (including  the ISO  adjustment)  is  allowed as a credit
against the optionee's  regular tax liability in subsequent years. To the extent
the credit is not used, it is carried forward.

OPTIONS GRANTED DURING LAST FISCAL YEAR TO EMPLOYEES AND CONSULTANTS

            The grant of  options  is within the  discretion  of the  Committee.
Accordingly, the Company is unable to determine future options, if any, that may
be granted to the persons or groups to which the following table  pertains.  Set
forth under the caption  "Executive  Compensation - Option Grants in Last Fiscal
Year",  above,  is information  concerning  options granted during the Company's
fiscal  year  ended  December  31,  1997 to the  persons  named  in the  Summary
Compensation  Table,  each of which  options  was  granted  under the Plan.  The
following  table sets forth the number of shares  underlying  options  that were
granted under the Plan during the Company's  fiscal year ended December 31, 1997
to (i) all  current  executive  officers  as a group and (ii) all other  current
employees as a group, including current officers who are not executive officers:



                                      -14-

<PAGE>




                                                           NUMBER OF SHARES
CATEGORY OF OPTIONEE                                  UNDERLYING OPTIONS GRANTED
- --------------------                                  --------------------------

Current executive officers as a group (6 persons,              420,000
   including the persons named in the Summary 
   Compensation Table)
Other employees as a group (18 persons)                        166,000

            The Company's three  non-employee  directors,  who were each granted
options to purchase  10,000  shares of Class A Common Stock under the  Company's
1993 Non-Employee Director Stock Option Plan in 1997 (see "Election of Directors
- - Remuneration of Directors"), are not entitled to participate in the Plan.

            The exercise price of all of the foregoing options was at least 100%
of the market value of the underlying shares on the date of grant. The foregoing
table does not include any dollar value that may arise from a future increase in
the market value of the  Company's  Class A Common  Stock.  On May 8, 1998,  the
closing price of the Company's Class A Common Stock on The Nasdaq Stock Market's
National Market was $1.563 per share.

REQUIRED VOTE

            Approval  of  the  proposed  amendment  to  the  Plan  requires  the
affirmative vote of a majority of the shares of Class A Common Stock and Class B
Common Stock present, in person or by proxy, at the Meeting and entitled to vote
on this proposal, voting together as one class, with Class A Common Stock having
one vote per share and Class B Common  Stock  having  ten votes per  share.  The
Board of Directors recommends a vote FOR approval of this proposal.



                                   PROPOSAL 3.

                RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS

            The Board of Directors has selected the firm of Arthur  Andersen LLP
as the  independent  auditors of the Company  for the year ending  December  31,
1998. Arthur Andersen LLP has acted for the Company in such capacity since 1989.
The Board proposes that the stockholders ratify such selection at the Meeting.

            Representatives of Arthur Andersen LLP are expected to be present at
the Meeting and will be afforded an  opportunity  to make a statement if they so
desire and to respond to appropriate questions.

REQUIRED VOTE

            The  affirmative  vote of a majority of the shares of Class A Common
Stock and Class B Common Stock  present,  in person or by proxy,  at the Meeting
and entitled to vote on this proposal,  voting together as one class, with Class
A Common  Stock  having one vote per share and Class B Common  Stock  having ten
votes per share, will be required to adopt this proposal. The Board of Directors
recommends that stockholders vote FOR approval of this proposal.




                                      -15-

<PAGE>


                                  MISCELLANEOUS

STOCKHOLDER PROPOSALS

            From time to time  stockholders  may present  proposals which may be
proper  subjects for inclusion in the proxy statement and form of proxy relating
to that meeting. In order to be considered,  such proposals must be submitted in
writing on a timely basis.  Stockholder proposals intended to be included in the
Company's  proxy  statement  and form of proxy  relating to the  Company's  next
Annual Meeting of Stockholders must be received at 1375 Akron Street,  Copiague,
New  York  11726,  by  January  15,  1999.  Any such  proposals,  as well as any
questions relating thereto, should be directed to the Secretary of the Company.

ANNUAL REPORT ON FORM 10-K

            A copy of the  Company's  Annual  Report  on Form  10-K for the year
ended  December 31, 1997,  which has been filed with the Securities and Exchange
Commission,  is  also  available,   without  charge,  to  stockholders  who  are
interested in more detailed  information about the Company.  Requests for a copy
of that report should be addressed to Timothy J. Roach, Treasurer, at 1375 Akron
Street, Copiague, New York 11726.

                                             By Order of the Board of Directors,


                                                      Timothy J. Roach
                                                         Secretary


May 15, 1998



                                                                -16-

<PAGE>



                       AMERICAN BIOGENETIC SCIENCES, INC.
            PROXY FOR ANNUAL MEETING OF STOCKHOLDERS - JUNE 18, 1998

           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

      The undersigned  hereby  appoints,  as proxies for the  undersigned,  AIDA
PADILLA,  TIMOTHY J. ROACH and  LEONARD W.  SUROFF,  or any one or more of them,
with full  power of  substitution,  to vote all shares of the  capital  stock of
American  Biogenetic  Sciences,  Inc. (the  "Company")  which the undersigned is
entitled to vote at the Annual Meeting of Stockholders of the Company to be held
on Thursday,  June 18, 1998,  at 3:00 P.M.,  Eastern  Daylight  Savings Time, at
Boston University,  595 Commonwealth Avenue, Boston,  Massachusetts,  and at any
adjournments or  postponements  thereof,  receipt of Notice of which meeting and
the Proxy  Statement  accompanying  the same being  hereby  acknowledged  by the
undersigned,  upon the  matters  described  in the Notice of  Meeting  and Proxy
Statement  and upon such other  business as may properly come before the meeting
and any  adjournments  or  postponements  thereof,  hereby  revoking any proxies
heretofore given.

      EACH  PROPERLY  EXECUTED  PROXY  WILL BE  VOTED  IN  ACCORDANCE  WITH  THE
SPECIFICATIONS  MADE BELOW AND ON THE REVERSE SIDE HEREOF.  IF NO SPECIFICATIONS
ARE MADE,  THE  PROXIES  WILL BE VOTED  FOR EACH  LISTED  NOMINEE  TO SERVE AS A
DIRECTOR AND FOR PROPOSALS 2 AND 3.

      A VOTE FOR EACH NOMINEE AND FOR  PROPOSALS 2 AND 3 IS  RECOMMENDED  BY THE
BOARD OF DIRECTORS.

      1.    Election of Directors (check one box only)

[_]   FOR EACH NOMINEE LISTED BELOW               [_]   WITHHOLD AUTHORITY
      (except as marked to the contrary below):         to vote for all nominees
                                                       listed below

            ALFRED J. ROACH,  ELLENA M. BYRNE,  STEPHEN H. IP, TIMOTHY J. ROACH,
            GUSTAV V. R. BORN, JOSEPH C. HOGAN and WILLIAM G. SHARWELL

(INSTRUCTION:  TO  WITHHOLD  AUTHORITY  TO VOTE  FOR ANY  NOMINEE,  CIRCLE  THAT
NOMINEE'S NAME IN THE ABOVE LIST)

                                    (continued and to be signed on reverse side)





<PAGE>



2.    To  approve an  amendment  to the  Company's  1996  Stock  Option  Plan to
      increase  the number of shares of Class A Common  Stock that may be issued
      thereunder from 1,000,000 shares to 2,000,000 shares.


          FOR                 AGAINST                  ABSTAIN
          [_]                   [_]                      [_]




3.    To ratify the selection of Arthur Andersen LLP as independent auditors for
      the Company.


          FOR                 AGAINST                  ABSTAIN
          [_]                   [_]                      [_]




                                                Dated:____________________, 1998
                                                
                                                
                                                ________________________________
                                                (SIGNATURE OF STOCKHOLDER)
                                                
                                                
                                                ________________________________
                                                (SIGNATURE OF STOCKHOLDER)
                                            

                                                NOTE:  PLEASE  SIGN YOUR NAME OR
                                                NAMES   EXACTLY   AS  SET  FORTH
                                                HEREON.    FOR   JOINTLY   OWNED
                                                SHARES,  EACH OWNER SHOULD SIGN.
                                                IF    SIGNING    AS    ATTORNEY,
                                                EXECUTOR, ADMINISTRATOR, TRUSTEE
                                                OR GUARDIAN, PLEASE INDICATE THE
                                                CAPACITY   IN   WHICH   YOU  ARE
                                                ACTING.   PROXIES   EXECUTED  BY
                                                CORPORATIONS SHOULD BE SIGNED BY
                                                A DULY  AUTHORIZED  OFFICER  AND
                                                SHOULD BEAR THE CORPORATE SEAL.

              PLEASE DATE AND SIGN THIS PROXY AND MAIL IT PROMPTLY
           IN THE ENCLOSED ENVELOPE. NO POSTAGE IS REQUIRED IF MAILED
                              IN THE UNITED STATES.



                                       -2-



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