AMERICAN BIOGENETIC SCIENCES INC
SC 13D, 1998-11-25
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  Schedule 13D

                    Under the Securities Exchange Act of 1934


                       American Biogenetic Sciences, Inc.
                       ---------------------------------
                                (Name of Issuer)

                 Class A Common Stock, par value $.001 per share
                 -----------------------------------------------
                         (Title of class of securities)

                                   024611 10 5
                                   -----------
                                 (CUSIP Number)

                             Leonard W. Suroff, Esq.
                       American Biogenetic Sciences, Inc.
                                1375 Akron Street
                            Copiague, New York 11726
                       -----------------------------------
                                  516-789-2600
            (Person Authorized to Receive Notices and Communications)

                                 October 1, 1998
                        ------------------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box [ ]


                                 Page 1 of 36 Pages


<PAGE>

CUSIP No.   024611-10-5            13D             Page  2   of   36 Pages
                                                                                
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    1    NAME OF REPORTING PERSON
         SS. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         Alfred J. Roach


    2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                (a)  [ ]        

                                                                (b)  [ ]
    3    SEC USE ONLY
           
    4    SOURCE OF FUNDS*
                  PF
           
    5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
         TO ITEM 2(d) OR 2(e)
                                                                      [ ]

          
    6    CITIZENSHIP OR PLACE OF ORGANIZATION
         UNITED STATES


      NUMBER OF           7    SOLE VOTING POWER
       SHARES                      8,195,250
                          
    BENEFICIALLY          8    SHARED VOTING POWER        
      OWNED BY                          -0-  
        EACH  
  
      REPORTING           9    SOLE DISPOSITIVE POWER     
       PERSON                         8,195,250                            
       
         WITH            10    SHARED DISPOSITIVE POWER   
                                         -0-

    11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY REPORTING PERSON             
          8,195,250 (includes 3,000,000 shares issuable upon conversion of 
          Class B Common Stock and 1,160,000 shares issuable upon exercise 
          of options)                                                 
                                                                             
    12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*


    13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
           20.7%   (52.8% of voting power of all outstanding securities)
  
    14   TYPE OF REPORTING PERSON*
                  IN

- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>

CUSIP No.   024611-10-5            13D             Page  3   of   36 Pages
                                                                                
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Item 1.      Security and Issuer

         This  statement  relates to the Class A Common  Stock,  $.001 par value
(the  "Class A Common  Stock"),  of  American  Biogenetic  Sciences,  Inc.  (the
"Company").  The Company's principal executive offices are located at 1375 Akron
Street, Copiague, New York 11726.

Item 2.  Identity and Background

                  (a)      This  statement  is filed by  Alfred  J.  Roach  (the
                           "Reporting Person").

                  (b)      The  residence  address  of the  Reporting  Person is
                           Route 2-Kennedy Avenue, Guaynabo, Puerto Rico 00657.

                  (c)      The  Reporting  Person  is  Chairman  of the Board of
                           Directors  of the  Company,  the  principal  business
                           address of which is 1375 Akron Street,  Copiague, New
                           York 11726.

                  (d)      During the last five years,  the Reporting Person has
                           not  been   convicted   in  a   criminal   proceeding
                           (excluding     traffic    violations    or    similar
                           misdemeanors).

                  (e)      During the last five years,  the Reporting Person has
                           not been a party to a civil  proceeding of a judicial
                           or administrative body of competent jurisdiction as a
                           result  of  which  the  Reporting  Person  was  or is
                           subject  to  a   judgment,   decree  or  final  order
                           enjoining  future  violations  of, or  prohibiting or
                           mandating  activities  subject  to,  Federal or State
                           securities  laws or  finding  of any  violation  with
                           respect to such laws.

                   (f)     The  Reporting  Person  is a  citizen  of the  United
                           States.

Item 3.  Source and Amount of Funds or Other Consideration

         All purchases of the  Company's  capital stock to date by the Reporting
Person have been made through the use of the Reporting  Person's personal funds.
No portion of the funds used by the Reporting  Person to purchase  capital stock
of the Company has been provided from borrowed monies.

Item 4.  Purpose of Transaction

         The  purpose of the  acquisition  of  securities  of the Company by the
Reporting Person has been to make investments in the Company, which has also had
the effect of the Reporting Person obtaining


<PAGE>

CUSIP No.   024611-10-5            13D             Page  4   of   36 Pages
                                                                                
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and  maintaining  control of the Company.  Except as noted below,  the Reporting
Person  does not have any  present  plans or  proposals  (although  the right to
develop such plans or proposals is reserved)  that relate to or would result in:
(i) the  acquisition or the  disposition of securities of the Company  (although
the Reporting  Person may, but is not obligated to,  purchase  securities of the
Company should the Company  require  additional  funds);  (ii) an  extraordinary
corporate  transaction,  such as a merger,  reorganization or liquidation of the
Company  or any of its  subsidiaries  (although  neither  the  Company  nor  the
Reporting  Person is presently a party to any  agreement or  understanding  with
respect  thereto,  the Company is engaged in an acquisition  strategy  which, if
successful,  could result in a business  combination  of the Company with one or
more  entities  which  are  unaffiliated  with  the  Reporting  Person;  and the
Reporting  Person,  as a director and  stockholder  of the Company  reserves the
right to vote to approve or disapprove of any such transaction); (iii) a sale or
transfer  of a  material  amount  of  assets  of  the  Company  or  any  of  its
subsidiaries; (iv) any change in the present board of directors or management of
the  Company,  including  any plans or proposals to change the number or term of
directors  or to fill any  existing  vacancies  on the board;  (v) any  material
change in the present capitalization or dividend policy of the Company; (vi) any
other material change in the Company's  business or corporate  structure;  (vii)
any  changes in the  Company's  charter,  by-laws or  instruments  corresponding
thereto or other  actions  which may impede  the  acquisition  of control of the
Company by any person; (viii) causing a class of securities of the Company to be
delisted  from a national  securities  exchange or cease to be  authorized to be
quoted in an inter-dealer  quotation system of a registered  national securities
association (except that the Company has received a letter from The Nasdaq Stock
Market,  Inc. to the effect  that if the market  price of the  Company's  Common
Stock does not exceed $1.00 per share for ten consecutive  trading days prior to
December 24, 1998, the Company's Class A Common Stock will be delisted from such
market on December 28, 1998);  (ix) causing a class of equity  securities of the
Company to become eligible for  termination of registration  pursuant to Section
12(g)(4) of the  Securities  Exchange Act of 1934; or (x) any action  similar to
any of those enumerated above.


<PAGE>

CUSIP No.   024611-10-5            13D             Page  5   of   36 Pages
                                                                                
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Item 5.  Interest in Securities of the Issuer

             The following information is as at November 23, 1998:

             (a)(i)  Amount Beneficially Owned: 8,195,250

Consists of (i) 4,035,250 shares of Class A Common Stock;  (ii) 3,000,000 shares
of Class A Common Stock issuable upon conversion of the same number of shares of
the Company's  Class B Common Stock,  $.001 par value ("Class B Common  Stock"),
each of which is owned by the Reporting Person and is convertible into one share
of Class A Common Stock;  (iii)  1,160,000  shares of Class A Common Stock which
are not  outstanding  but which are subject to issuance upon exercise of options
granted to the  Reporting  Person  under the  Company's  stock option plans (the
"Options"), all of which were fully exercisable on November 23, 1998. Each share
of Class B Common  Stock is  entitled  to ten times the  number of votes of each
share of Class A Common Stock.

             (ii) Percent of Class:  20.7% of Class A Common  Stock and 52.8% of
                  the voting  power of the  Company's  Class A Common  Stock and
                  Class B Common Stock when voting together as a single class.

Percent  of  Class  is  based on  35,525,306  shares  of  Class A  Common  Stock
outstanding on November 23, 1998 and assuming  conversion of all shares of Class
B Common Stock  beneficially  owned by the Reporting  Person and the exercise of
the  Options.  Percent of voting  power  assumes  the  foregoing  except that it
assumes  that the Class B Common  Stock  remains  outstanding  rather than being
converted.

             (b) Number of shares to which such person has:

                        (i) sole power to vote or to direct the vote - 8,195,250
                       (ii) shared power to vote or to direct the vote - 0 
                      (iii) sole  power  to dispose or to direct the disposition
                            of -  8,195,250  
                       (iv) shared power to dispose or to direct the disposition
                            of - 0



<PAGE>

CUSIP No.   024611-10-5            13D             Page  6   of   36 Pages
                                                                                
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             (c)  The  following  is a  schedule  of  the  transactions  of  the
Reporting Person in the Company's capital stock since September 1, 1998:
<TABLE>
<CAPTION>


     Date of                           Number of Shares                   Total Purchased
   Transaction       Class      Acquired         Disposed of    Price     or Disposed of
   -----------       -----      --------         -----------    -----     --------------

<S>             <C>           <C>           <C>             <C>         <C>                      
     10/1/98        Class A                      50,000         N/A         Gift
     10/1/98        Class B       500,000                        $.40625    From Company
     10/6/98        Class B       724,500                        $.3125     From Company
     10/27/98       Class A     4,000,000                        $.25       From Company
     10/29/98       Class A         5,000                        $.4265     Open Market 
     10/29/98       Class A         5,000                        $.365      Open Market 
     11/02/98       Class A                     860,000         N/A         Gifts       
</TABLE>
                                                                                
             (d) No other  person is known to have the right to receive,  or the
power to direct the receipt of,  dividends  from,  or the proceeds from the sale
of, the securities of the Company owned by the Reporting Person.

             (e) Not applicable.

Item 6.  Contracts, Arrangements, Understandings or Relationships
             with Respect to Securities of the Issuer.

             The  Reporting  Person does not have any  contracts,  arrangements,
understandings or relationship (legal or otherwise) with any person with respect
to securities issued by the Company, including, but not limited to, the transfer
or voting of any such securities,  finder's fees, joint ventures, loan or option
arrangements, puts or calls, guarantees or profits, divisions or profits or loss
or the giving or  withholding  of  proxies,  except for  employee  stock  option
agreements  entered into between the Reporting  Person and the Company under the
Company's stock option plans.

Item 7.  Material to be Filed as Exhibits

         Exhibit 1 -       Incentive  Stock  Option  Agreement  dated August 19,
                           1991 between the Company and the Reporting Person.




<PAGE>

CUSIP No.   024611-10-5            13D             Page  7   of   36 Pages     
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         Exhibit 2 -       Incentive  Stock Option  Agreement  dated October 25,
                           1991 between the Company and the Reporting Person.

         Exhibit 3 -       Incentive  Stock Option  Agreement  dated October 19,
                           1992 between the Company and the Reporting Person.

         Exhibit 4 -       Incentive  Stock Option  Agreement dated June 1, 1995
                           between the Company and the Reporting Person.

                                    SIGNATURE

         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.

Dated: November 25, 1998

                                                        /s/ Alfred J. Roach
                                                            --------------------
                                                            Alfred J. Roach


CUSIP No.   024611-10-5            13D             Page  8   of   36 Pages     
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                                                                       Exhibit 1
                                                                       ---------
                                                                                

                       AMERICAN BIOGENETIC SCIENCES, INC.
                       ---------------------------------
                        INCENTIVE STOCK OPTION AGREEMENT
                        --------------------------------

                  OPTION  AGREEMENT  made this 19th day of August 1991,  between
AMERICAN BIOGENIC  SCIENCES,  INC . ("Company") and Alfred J. Roach, an employee
of the Company ("Optionee"), residing at 1385 Akron Street, Copiague, NY. 11726.

                              W I T N E S S E T H:

                  WHEREAS,  the Company  desires,  by affording  the Optionee an
opportunity to purchase its common stock, $.001 par value per share (the "Common
Stock"),  as  hereinafter  provided,  to carry out the purposes of the Company's
Stock Option Plan (the "Plan"):

                  NOW,  THEREFORE,  in  consideration of the premises and of the
mutual promises hereinafter contained, the parties hereto agree as follows:

                  1. Grant of Option.  The Company hereby grants to the Optionee
an option  ("Option")  to purchase  all or any part of an  aggregate  of 375,000
shares of Common Stock (such number being  subject to  adjustment as provided in
Section 9 hereof) an the terms and conditions  hereinafter set forth. The Option
is intended to be an "incentive  stock option" as defined in Section 422A of the
Internal Revenue Code of 1986 or any corresponding  provisions of succeeding law
(the "Code").

                  2. Purchase Price.  The purchase price of the shares of Common
Stock covered by the Option shall be $4.81 per share of Common  Stock,  which is
not less than one

<PAGE>

CUSIP No.   024611-10-5            13D             Page  9   of   36 Pages     
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hundred  percent  (100%) of the fair market  value of a share of Common Stock on
the date  hereof.  Payment  shall be made in cash,  check or in shares of Common
Stock in the manner prescribed in Section 10 hereof.

                  3.  Term of  Option.  The  term of the  Option  shall be for a
period of ten (10) years from the date hereof, subject to earlier termination as
provided in Sections 6, 7 and a hereof.

                  4. Exercisability.  The option may be exercised in whole or in
part at any time and from time to time prior to the  termination  of the Option,
as to all or any of the  shares  of Common  Stock  then  purchasable  hereunder;
provided,  however,  that no shares of Common Stock covered by the Option may be
purchased within the first twelve months' period after the date hereof, and that
in each  subsequent  twelve  months'  period during the term of the Option,  the
holder of the option may  purchase a number of shares of Common  Stock  equal to
one 100% of the total  number of shares  subject to the Option until one hundred
percent of the Option shall be exercisable (1) years after the date hereof).  If
fewer than the number of available  shares are purchased in any period under the
Option,  the holder may purchase any such  unpurchased  shares in any subsequent
period during the term of the Option.  In no event shall the Option be exercised
after the expiration of ten (10) years from the date hereof.

                  Except as provided in Sections 6, 7 and 3.0 hereof, the Option
may not be  exercised  at any time unless the  Optionee  shall then be and shall
have been, at all times from the date of grant of the Option, an employee of the
Company or of a subsidiary  of the Company.  The term  "employee"  shall include
officers and  directors  who are  employees  of the  Company.  The holder of the
Option  shall not have any of the rights of a  shareholder  of the Company  with
respect

                                        2

<PAGE>

CUSIP No.   024611-10-5            13D             Page  10   of   36 Pages     
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to  the  shares  of  Common  Stock  covered  by the  Option  until  one or  more
certificates  for such shares of Common Stock shall have been issued to him upon
the due exercise of the Option.

                  5.  Non-transferability.  The Option shall not be transferable
otherwise than by will or the laws of descent and  distribution,  and the Option
may be  exercised  during  the  lifetime  of the  Optionee  only  by  him,  more
particularly (but without limiting the generality of the foregoing),  the Option
may  not be  assigned,  transferred  (except  as  provided  above),  pledged  or
hypothecated  in any way, shall not be assignable by operation of law, and shall
not be subject  to  execution,  attachment  or similar  process.  Any  attempted
assignment,  transfer, pledge,  hypothecation or other disposition of the Option
contrary to the provisions hereof, and the levy of any execution, attachment, or
similar process upon the Option, shall be null and void and without effect.

                  6. Employment.  The granting of the Option is in consideration
of the Optionee's continuing employment by the Company; however, nothing in this
Option shall confer upon the Optionee the right to continue in the employment of
the  Company or affect  the right of the  Company to  terminate  the  Optionee's
employment at any time in its sole discretion, with or without cause.

                  In the event that the  Optionee  shall cease to be so employed
for any reason other than death,  retirement  with the consent of the Company or
disability (as  determined by the committee  appointed by the Board of Directors
of the Company to administer the Plan (the  "Committee") in its sole discretion,
the Option shall terminate on the date of termination of employment or on a date
not more than three (3) months after such date of  termination of employment (as
determined by the Committee in its sole discretion);  provided, however, that in
the event of exercise after termination of employment, the Optionee shall not be
entitled to

                                        3

<PAGE>

CUSIP No.   024611-10-5            13D             Page  11   of   36 Pages     
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purchase  any shares of Common  Stock in excess of the number of shares which he
would have been permitted to purchase upon exercise of the Option an his date of
termination.  If the Optionee is disabled (as determined by the Committee in its
sole  discretion)  or retires with the consent of the Company,  the Option shall
terminate one (1) year after the date of disability and not later than three (3)
months after the date of retirement  (as determined by the Committee in its sole
discretion).

                  7. Death Of Optionee,.  If the Optionee shall die while in the
employ of the Company or a  subsidiary  of the  Company,  his  estate,  personal
representative,  or beneficiary shall have the right,  subject to the provisions
of Section 3 hereof,  to exercise  the Option (to the extent  that the  Optionee
would have been  entitled  to do so at the date of his death) at any time within
one (1) year from the date of his death.

                  8.  Termination of Option.  In the event of the institution of
any legal proceedings directed to the validity of the Plan pursuant to which the
Option is granted,  or to any option  granted  under it, the Company may, in its
sole discretion, and without incurring any liability therefor to the Optionee or
any other person, terminate the Option.

                  9. Stock  Splits,  Mergers,  Etc. In case of any stock  split,
stock dividend or similar transaction which increases or decreases the number of
outstanding shares of Common Stock, appropriate adjustment sh all be made by the
Board of Directors,  whose determination shall be final, to the number of shares
of Common Stock which may be purchased  under the Plan and the number and option
exercise price per share which may be purchased under any  outstanding  options.
In the case of a merger,  sale of assets or similar transaction which results in
a  replacement  of the  Company's  shares of Common  Stock with stock of another
corporation, the

                                        4

<PAGE>

CUSIP No.   024611-10-5            13D             Page 12   of   36 Pages     
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Company will make a reasonable effort, but shall not be required, to replace any
outstanding  options with comparable options to purchase the stock of such other
corporation,  or will provide for immediate maturity of all outstanding options,
with all options not being  exercised  within the time period  specified  by the
Board of Directors being terminated.

                  10.  Method of  Exercising  Option.  Subject  to the terms and
conditions  of this Option  Agreement,  the Option may be  exercised  by written
notice to the Company as  provided  in Section  11. Such notice  shall state the
election  to  exercise  the Option  and the number of shares of Common  Stock in
respect  of which it is being  exercised.  It shall be signed  by the  person or
persons so exercising the Option and shall be accompanied by payment of the full
purchase  price  of  such  shares  in  cash,  by  check  or by the  delivery  of
certificates  representing  shares of Common  Stock  with fully  executed  stock
powers,  and the  Company  shall  issue,  in the name of the  person or  persons
exercising the Option,  and deliver a certificate or  certificates  representing
such shares of Common Stock as soon as practicable  after the notice and payment
have been received.

                  In the event the Option  shall be  exercised  by any person or
persons other than the Optionee, pursuant to Section 7 hereof, such notice shall
be accompanied  by  appropriate  proof of the right of such person or persons to
exercise the Option. All shares of Common Stock that shall be purchased upon the
exercise   of  the  Option  as   provided   herein   shall  be  fully  paid  and
non-assessable.

                  11. General. The Company shall at all times during the term of
the Option  reserve and keep  available such number of shares of Common Stock as
will be sufficient to satisfy the requirements of this Agreement,  shall pay all
taxes with respect to the issue of shares of- Common Stock  pursuant  hereto and
all other fees and expenses necessarily incurred by the

                                        5

<PAGE>

CUSIP No.   024611-10-5            13D             Page  13   of   36 Pages     
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Company  in  connection  therewith,  and will,  from time to time,  use its best
efforts to comply with all laws and regulations which, in the opinion of counsel
for the Company, shall be applicable thereto.

                  12.  Representation of Optionee.  The Optionee represents that
he and any related  persons or entities,  within  Section 425(d) of the Code, do
not own as much as ten percent (10%) of the total combined voting power or value
of all capital stock of the Company,  or any subsidiary of' the Company,  and in
accepting the Option herein granted to him, agrees to the terms of the Option on
the date hereof.

                  13.  Notices.  Each notice  relating to this Option  Agreement
shall be in writing and  delivered  in person or by first  class  mail,  postage
prepaid,  to the proper address.  Each notice shall be deemed to have been given
on the date it is received.  Each notice to the Company shall be addressed to it
at its principal office (Attention:  Treasurer).  Each notice to the Optionee or
other person or persons then  entitled to exercise the Option shall be addressed
to the  Optionee or such other person or persons at the  Optionee's  address set
forth in the  heading  of this  Agreement.  Anyone to whom a notice may be given
under this Agreement may designate a new address by notice to that affect.

                  14.  Incorporation  of Plan.  Notwithstanding  the  terms  and
conditions  herein,  any Option  granted  pursuant  to this  Agreement  shall be
subject to and governed by all the terms and  conditions  of the Plan. A copy of
the Plan has been  delivered  to the  Optionee  and is  hereby  incorporated  by
reference.  In the  event  of any  discrepancy  or  inconsistency  between  this
Agreement and the Plan, the terms of the Plan shall govern.

                                        6

<PAGE>

CUSIP No.   024611-10-5            13D             Page  14   of   36 Pages     
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                  15.  Enforceability.  This Agreement shall be binding upon the
Optionee, his estate, his personal representatives and beneficiaries.

                  IN WITNESS  WHEREOF,  the Company has caused this Agreement to
be duly  executed by one of its  officers  thereunto  duly  authorized,  and the
Optionee  has  hereunto  set his hand,  all as of the day and year  first  above
written.
                                 
                                       
                                         AMERICAN BIOGENETIC SCIENCES, INC.     
                                                                                
                                                                                
                                                                                
                                         By: /s/ Timothy J. Roach               
                                             -------------------------------
                                                 Timothy J. Roach               
                                         Title: Secretary-Treasurer             
                                                                                
                                                                                
                                                                                
                                         Optionee:                              
                                                                                
                                            /s/  Alfred J. Roach                
                                          -----------------------------------   
                                                 Alfred J. Roach                
                                                                                
                                        7
                                                                                


CUSIP No.   024611-10-5            13D             Page  15   of   36 Pages     
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                                                                       Exhibit 2
                                                                       ---------


                       AMERICAN BIOGENETIC SCIENCES, INC.
                       ---------------------------------
                        INCENTIVE STOCK OPTION AGREEMENT
                        ---------------------------------

                  OPTION AGREEMENT made this 25th day of October 1991, between
AMERICAN BIOGENETIC SCIENCES, INC. ("Company") and Alfred J. Roach, an employee
of the Company ("Optionee"), residing at P.O. Box 1001, Notre Dame, Ind. 46556

                              W I T N E S S E T H:

                  WHEREAS,  the Company  desires,  by affording  the Optionee an
opportunity to purchase its common stock, $.001 par value per share (the "Common
Stock") , as  hereinafter  provided,  to carry out the purposes of the company's
Stock Option Plan (the "Plan"):

                  NOW,  THEREFORE,  in  consideration of the premises and of the
mutual promises hereinafter contained, the parties hereto agree as follows:

                  1. Grant of Option.  The Company hereby grants to the Optionee
an option  ("Option")  to purchase all or any part of an aggregate  of,  350,000
shares of Common Stock (such number being  subject to  adjustment as provided in
Section 9 hereof) on the terms and conditions  hereinafter set forth. The Option
is intended to be an "incentive  stock option" as defined in Section 422A of the
Internal Revenue Code of 1986 or any corresponding  provisions of succeeding law
(the "Code").

<PAGE>

CUSIP No.   024611-10-5            13D             Page  16   of   36 Pages     
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                  2. Purchase Price.  The purchase price of the shares of Common
Stock covered by the Option shall be $5.50 per share of Common  Stock,  which is
not less than one hundred  percent (100%) of the fair market value of a share of
Common  Stock on the date  hereof.  Payment  shall be made in cash,  check or in
shares of Common Stock in the manner prescribed in Section 10 hereof.

                  3.  Term of  Option.  The  term of the  Option  shall be for a
period of ten (10) years from the date hereof, subject to earlier termination as
provided in Sections 6, 7 and 8 hereof.

                  4. Exercisability.  The option may be exercised in whole or in
part at any time and from time to time prior to the  termination  of the Option,
as to all or any of the  shares  of Common  Stock  then  purchasable  hereunder;
provided,  however,  that no shares of Common Stock covered by the Option may be
purchased  within the first * months' period after the date hereof,  and that in
each  subsequent * months'  period during the term of the Option,  the holder of
the Option may purchase a number of shares of Common Stock equal to one * of the
total number of shares  subject to the Option  until one hundred  percent of the
Option shall be  exercisable  on October 25,  1992.  If fewer than the number of
available  shares are  purchased in any period under the Option,  the holder may
purchase any such unpurchased shares in any subsequent period during the term of
the Option.  In no event shall the Option be exercised  after the  expiration of
ten (10) years from the date hereof.

                  Except as provided in Sections 6, 7 and 10 hereof,  the Option
may not be  exercised  at any time unless the  Optionee  shall then be and shall
have been, at all times from the

- --------
*  100% will become exercisable on October 25, 1992.

                                        2

<PAGE>

CUSIP No.   024611-10-5            13D             Page  17   of   36 Pages     
- --------------------------------------------------------------------------------


date of grant of the Option,  an employee of the Company or of a  subsidiary  of
the Company.  The term "employee"  shall include  officers and directors who are
employees  of the  Company.  The holder of the Option  shall not have any of the
rights of a  shareholder  of the  Company  with  respect to the shares of Common
Stock  covered by the Option until one or more  certificates  for such shares of
Common Stock shall have been issued to him upon the due exercise of the Option.

                  5.  Non-transferability.  The Option shall not be transferable
otherwise than by will or the laws of descent and  distribution,  and the Option
may be  exercised  during  the  lifetime  of the  Optionee  only  by  him,  more
particularly (but without limiting the generality of the foregoing),  the Option
may  not be  assigned,  transferred  (except  as  provided  above),  pledged  or
hypothecated  in any way, shall not be assignable by operation of law, and shall
not be subject  to  execution,  attachment  or similar  process.  Any  attempted
assignment,  transfer, pledge,  hypothecation or other disposition of the Option
contrary to the provisions hereof, and the levy of any execution, attachment, or
similar process upon the Option, shall be null and void and without effect.

                  6. Employment.  The granting of the Option is in consideration
of the Optionee's continuing employment by the Company; however, nothing in this
Option shall confer upon the Optionee the right to continue in the employment of
the  Company or affect  the right of the  Company to  terminate  the  Optionee's
employment at any time in its sole discretion, with or without cause.

                  In the event that the  Optionee  shall cease to be so employed
for any reason other than death,  retirement  with the consent of the Company or
disability (as  determined by the committee  appointed by the Board of Directors
of the Company to administer the Plan (the

                                        3

<PAGE>

CUSIP No.   024611-10-5            13D             Page  18   of   36 Pages     
- --------------------------------------------------------------------------------


"Committee") in its sole  discretion,  the Option shall terminate on the date of
termination of employment or on a date not more than three (3) months after such
date of  termination  of employment  (as determined by the committee in its sole
discretion);  provided, however, that in the event of exercise after termination
of  employment,  the  Optionee  shall not be entitled to purchase  any shares of
Common  Stock in  excess  of the  number  of  shares  which he would  have  been
permitted to purchase upon exercise of the Option on his date of termination. If
the Optionee is disabled (as determined by the Committee in its sole discretion)
or retires with the consent of the Company,  the Option shall  terminate one (1)
year after the date of disability and not later than three (3) months after. the
date of retirement (as determined by the committee in its sole discretion).

                  7. Death of Optionee.  If the Optionees shall die while in the
employ of the Company or a  subsidiary  of the  Company,  his  estate,  personal
representative,  or beneficiary shall have the right,  subject to the provisions
of Section 3 hereof,  to exercise  the Option (to the extent  that the  Optionee
would have been  entitled  to do so at the date of his death) at any time within
one (1) year from the date of his death.

                  8.  Termination of Option.  In the event of the institution of
any legal proceedings directed to the validity of the Plan pursuant to which the
Option is granted,  or to any option  granted  under it, the Company may, in its
sole discretion, and without incurring any liability therefor to the Optionee or
any other person, terminate the Option.

                  9. Stock  Splits,  Mergers,  Etc. In case of any stock  split,
stock dividend or similar transaction which increases or decreases the number of
outstanding shares of Common Stock,  appropriate adjustment shall be made by the
Board of Directors, whose determination shall

                                        4

<PAGE>

CUSIP No.   024611-10-5            13D             Page  19   of   36 Pages     
- --------------------------------------------------------------------------------


be final,  to the number of shares of Common  Stock which may be  purchased  the
Plan and the number and option  exercise  price per share which may be purchased
under  any  outstanding-  options.  In the case of a  merger,  sale of assets or
similar  transaction  which results in a replacement of the Company's  shares of
Common  Stock  with  stock of  another  corporation,  the  Company  will  make a
reasonable effort, but shall not be required, to replace any outstanding options
with comparable options to purchase the stock of such other corporation, or will
provide for immediate maturity of all outstanding options,  with all options not
being exercised within the time period specified by the Board of Directors being
terminated.

                  10.  Method of  Exercising  Option.  Subject  to the terms and
conditions  of this Option  Agreement,  the Option may be  exercised  by written
notice to the Company as  provided  in Section  11. Such notice  shall state the
election  to  exercise  the option  and the number of shares of Common  Stock in
respect  of which it is being  exercised.  It shall be signed  by the  person or
persons so exercising the Option and shall be accompanied by payment of the full
purchase  price  of  such  shares  in  cash,  by  check  or by the  delivery  of
certificates  representing  shares of Common  Stock  with fully  executed  stock
powers,  and the  Company  shall  issue,  in the name of the  person or  persons
exercising the Option,  and deliver a certificate or  certificates  representing
such shares of Common Stock as soon as practicable  after the notice and payment
have been received.

                  In the event the Option  shall be  exercised  by any person or
persons other than the Optionee, pursuant to Section 7 hereof, such notice shall
be accompanied  by  appropriate  proof of the right of such person or persons to
exercise the Option. All shares of Common Stock that shall be purchased upon the
exercise   of  the  Option  as   provided   herein   shall  be  fully  paid  and
non-assessable.

                                        5

<PAGE>

CUSIP No.   024611-10-5            13D             Page  20   of   36 Pages     
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                  11. General. The Company shall at all times during the term of
the Option  reserve and keep  available such number of shares of Common Stock as
will be sufficient to satisfy the requirements of this Agreement,  shall pay all
taxes with respect to the issue of shares of- Common Stock  pursuant  hereto and
all other fees and expenses  necessarily  incurred by the Company in  connection
therewith,  and will, from time to time, use its best efforts to comply with all
laws and regulations which, in the opinion of counsel for the Company,  shall be
applicable thereto.

                  12. Representation  Optionee.  The optionee represents that he
and any related  persons or entities,  within Section 425(d) of the Code, do not
own as much as ten percent (10%) of the total combined  voting power or value of
all capital  stock of the Company,  or any  subsidiary  of the  Company,  and in
accepting the option herein granted to him, agrees to the terms of the option on
the date hereof.

                  13.  Notices.  Each notice  relating to this Option  Agreement
shall be in writing and  delivered  in person or by first  class  mail,  postage
prepaid,  to the proper address.  Each notice shall be deemed to have been given
on the date it is received.  Each notice to the Company shall be addressed to it
at its principal office (Attention:  Treasurer).  Each notice to the Optionee or
other person or persons then  entitled to exercise the Option shall be addressed
to the  Optionee or such other person or persons at the  Optionee's  address set
forth in the  heading  of this  Agreement.  Anyone to whom a notice may be given
under this Agreement may designate a new address by notice to that effect.

                  14.  Incorporation  of Plan.  Notwithstanding  the  terms  and
conditions  herein,  any Option  granted  pursuant  to this  Agreement  shall be
subject to and governed by all the terms

                                        6

<PAGE>

CUSIP No.   024611-10-5            13D             Page   21  of   36 Pages     
- --------------------------------------------------------------------------------


and  conditions  of the  Plan.  A copy of the  Plan has  been  delivered  to the
Optionee  and  is  hereby  incorporated  by  reference.  In  the  event  of  any
discrepancy or  inconsistency  between this Agreement and the Plan, the terms of
the Plan shall govern.

                  15.  Enforceability.  This Agreement shall be binding upon the
Optionee, his estate, his personal representatives and beneficiaries.

                  IN WITNESS  WHEREOF,  the Company has caused this Agreement to
be duly  executed by one of its  officers  thereunto  duly  authorized,  and the
Optionee  has  hereunto  set his hand,  all as of the day and year  first  above
written.

                                        
                                         AMERICAN BIOGENETIC SCIENCES, INC. 
                                                                            
                                                                            
                                                                            
                                         By: /s/ Timothy J. Roach           
                                             -------------------------------
                                                 Timothy J. Roach           
                                         Title: Secretary-Treasurer         
                                                                            
                                                                            
                                                                            
                                         Optionee:                          
                                                                            
                                            /s/  Alfred J. Roach            
                                          ----------------------------------
                                                 Alfred J. Roach 

                                       7


CUSIP No.   024611-10-5            13D             Page  22   of   36 Pages     
- --------------------------------------------------------------------------------
                                                                      
                                                                       Exhibit 3
                                                                       ---------



                       AMERICAN BIOGENETIC SCIENCES, INC.
                       ---------------------------------
                        INCENTIVE STOCK OPTION AGREEMENT
                        --------------------------------

                  OPTION AGREEMENT made this 19th day of October, 1992, between
AMERICAN BIOGENETIC SCIENCES, INC. ("Company"), and Alfred J. Roach, an-employee
of the Company ("Optionee"), residing at P.O. Box 1001, Notre Dame, In. 46556.

                              W I T N E S S E T H:

                  WHEREAS,  the Company  desires,  by affording  the Optionee an
opportunity to purchase its common stock, $.001 par value per share (the "Common
Stock"),  as  hereinafter  provided,  to carry out the purposes of the Company's
Stock option Plan (the "Plan"):

                  NOW,  THEREFORE,  in  consideration of the premises and of the
mutual promises hereinafter contained, the parties hereto agree as follows:

                  1. Grant of Option.  The Company hereby grants to the Optionee
an option  ("Option"')  to purchase  all or any part of an  aggregate of 300,000
shares of Common Stock (such number being  subject to  adjustment as provided in
Section 9 hereof) on the terms and conditions  hereinafter set forth. The Option
is intended to be an "incentive  stock option" as defined in Section 422A of the
Internal Revenue Code of 1986 or any corresponding  provisions of succeeding law
(the "Code").

<PAGE>

CUSIP No.   024611-10-5            13D             Page  23   of   36 Pages     
- --------------------------------------------------------------------------------


                  2. Purchase Price.  The purchase price of the shares of Common
Stock covered by the option shall be $5.09 per share of Common  Stock,  which is
not less than one hundred  percent (100%) of the fair market value of a share of
Common  Stock on the date  hereof.  Payment  shall be made in cash,  check or in
shares of Common Stock in the manner prescribed in Section 10 hereof.

                  3.  Term of  Option.  The  term of the  option  shall be for a
period of ten (10) years from the date hereof, subject to earlier termination as
provided in Sections 6, 7 and 8 hereof.

                  4. Exercisability.  The Option may be exercised in whole or in
part at any time and f rom time to time prior to the  termination of the Option,
as to all or any of the  shares  of Common  Stock  then  purchasable  hereunder;
provided,  however,  that no shares of Common Stock covered by the Option may be
purchased within the first twelve months' period after the date hereof, and that
in each  subsequent  twelve  months'  period during the term of the Option,  the
holder of the Option may  purchase a number of shares of Common  Stock  equal to
one  quarter  of the total  number of shares  subject  to the  Option  until one
hundred  percent of the Option  shall be  exercisable  (4) years  after the date
hereof).  If fewer than the number of  available  shares  are  purchased  in any
period under the Option,  the holder may purchase any such unpurchased shares in
any  subsequent  period  during the term of the  Option.  In no event  shall the
Option be exercised after the expiration of ten (10) years from the date hereof.

                  Except as provided in Sections 6, 7 and 10 hereof,  the Option
may not be  exercised  at any time unless the  Optionee  shall then be and shall
have been, at all times from the date of grant of the Option, an employee of the
Company or of a subsidiary of the Company. The

                                        2

<PAGE>

CUSIP No.   024611-10-5            13D             Page  24   of   36 Pages     
- --------------------------------------------------------------------------------


term  "employee"  shall include  officers and directors who are employees of the
Company.  The  holder  of the  Option  shall  not  have any of the  rights  of a
shareholder of the Company with respect to the shares of Common Stock covered by
the Option until one or more  certificates for such shares of Common Stock shall
have been issued to him upon the due exercise of the Option.

                  5.  Non-transferability.  The Option shall not be transferable
otherwise than by will or the laws of descent and  distribution,  and the Option
may be  exercised  during  the  lifetime  of the  Optionee  only  by  him,  more
particularly (but without limiting the generality of the foregoing),  the Option
may  not be  assigned,  transferred  (except  as  provided  above),  pledged  or
hypothecated  in any way, shall not be assignable by operation of law, and shall
not be subject  to  execution,  attachment  or similar  process.  Any  attempted
assignment  transfer,  pledge,  hypothecation or other disposition of the Option
contrary to the provisions hereof, and the levy of any execution, attachment, or
similar process upon the Option, shall be null and void and without effect.

                  6. Employment.  The granting of the Option is in consideration
of the Optionee's continuing employment by the Company; however, nothing in this
Option shall confer upon the Optionee the right to continue in the employment of
the  Company or affect  the right of the  Company to  terminate  the  Optionee's
employment at any time in its sole discretion, with or without cause.

                  In the event that the  Optionee  shall cease to be so employed
for any reason other than death,  retirement  with the consent of the Company or
disability (as  determined by the committee  appointed by the Board of Directors
of the Company to administer the Plan (the  "Committee") in its sole discretion,
the Option shall terminate on the date of termination of employment or on a date
not more than three (3) months after such date of termination of

                                        3

<PAGE>

CUSIP No.   024611-10-5            13D             Page  25   of   36 Pages     
- --------------------------------------------------------------------------------


employment  (as determined by the Committee in its sole  discretion);  provided,
however,  that in the event of exercise after  termination  of  employment,  the
optionee  shall not be entitled to purchase any shares of Common Stock in excess
of the number of shares  which he would have been  permitted  to  purchase  upon
exercise of the Option on his date of  termination.  If the Optionee is disabled
(as  determined  by the  Committee in its sole  discretion)  or retires with the
consent of the Company,  the Option shall  terminate one (1) year after the date
of  disability  and not later than three (3) months after the date of retirement
(as determined by the Committee in its sole discretion).

                  7. Death Of Optionee.  If the Optionee  shall die while in the
employ of the Company or a  subsidiary  of the  Company,  his  estate,  personal
representative,  or beneficiary shall have the right,  subject to the provisions
of Section 3 hereof,  to exercise  the Option (to the extent  that the  Optionee
would have been  entitled  to do so at the date of his death) at any time within
one (1) year from the date of his death.

                  8.  Termination of Option.  In the event of the institution of
any legal proceedings directed to the validity of the Plan pursuant to which the
Option is granted,  or to any option  granted  under it, the Company may, in its
sole discretion, and without incurring any liability therefor to the Optionee or
any other person, terminate the Option.

                  9. Stock  Splits,  Mergers,  Etc. In case of any stock  split,
stock dividend or similar transaction which increases or decreases the number of
outstanding shares of Common Stock,  appropriate adjustment shall be made by the
Board of Directors,  whose determination shall be final, to the number of shares
of Common Stock which may be purchased  under the Plan and the number and option
exercise price per share which may be purchased under any outstanding

                                        4

<PAGE>

CUSIP No.   024611-10-5            13D             Page  26   of   36 Pages     
- --------------------------------------------------------------------------------


options.  In the case of a merger,  sale of assets or similar  transaction which
results in a replacement  of the Company's  shares of Common Stock with stock of
another corporation, the Company will make a reasonable effort, but shall not be
required, to replace any outstanding options with comparable options to purchase
the stock of such other  corporation,  or will provide for immediate maturity of
all outstanding  options,  with all options not being exercised  within the time
period specified by the Board of Directors being terminated.

                  10.  Method of  Exercising  Option.  Subject  to the terms and
conditions  of this Option  Agreement,  the Option may be  exercised  by written
notice to the Company as  provided  in Section  11. Such notice  shall state the
election  to  exercise  the Option  and the number of shares of Common  Stock in
respect  of which it is being  exercised.  It shall be signed  by the  person or
persons so exercising the Option and shall be accompanied by payment of the full
purchase  price  of  such  shares  in  cash,  by  check  or by the  delivery  of
certificates  representing  shares of Common  Stock  with fully  executed  stock
powers,  and the  Company  shall  issue,  in the name of the  person or  persons
exercising the Option,  and deliver a certificate or  certificates  representing
such shares  Common  Stock as soon as  practicable  after the notice and payment
have been received.

                  In the event the Option  shall be  exercised  by any person or
persons other than the Optionee, pursuant to Section 7 hereof, such notice shall
be accompanied  by  appropriate  proof of the right of such person or persons to
exercise the Option. All shares of Common Stock that shall be purchased upon the
exercise   of  the  Option  as   provided   herein   shall  be  fully  paid  and
non-assessable.

                  11. General. The Company shall at all times during the term of
the Option  reserve and keep  available such number of shares of Common Stock as
will be sufficient to satisfy

                                        5

<PAGE>

CUSIP No.   024611-10-5            13D             Page  27   of   36 Pages     
- --------------------------------------------------------------------------------


the  requirements  of this  Agreement,  shall pay all taxes with  respect to the
issue of shares of Common Stock pursuant  hereto and all other fees and expenses
necessarily incurred by the Company in connection therewith, and will, from time
to time, use its best efforts to comply with all laws and regulations  which, in
the opinion of counsel for the Company, shall be applicable thereto.

                  12.  Representation Of Optionee.  The Optionee represents that
he and any related  persons or entities,  within  Section 425(d) of the Code, do
not own as much as ten percent (10%) of the total combined voting power or value
of all capital stock of the Company,  or any  subsidiary of the Company,  and in
accepting the Option herein granted to him, agrees to the terms of the Option on
the date hereof.

                  13.  Notices.  Each notice  relating to this Option  Agreement
shall be in writing and  delivered  in person or by first  class  mail,  postage
prepaid,  to the proper address.  Each notice shall be deemed to have been given
on the date it is received.  Each notice to the Company shall be addressed to it
at its principal office (Attention:  Treasurer).  Each notice to the Optionee or
other person or persons then  entitled to exercise the Option shall be addressed
to the  Optionee or such other person or persons at the  Optionee's  address set
forth in the  heading  of this  Agreement.  Anyone to whom a notice may be given
under this Agreement may designate a new address by notice to that effect.

                  14.  Incorporation  of Plan.  Notwithstanding  the  terms  and
conditions  herein,  any Option  granted  pursuant  to this  Agreement  shall be
subject to and governed by all the terms and  conditions  of the Plan. A copy of
the Plan has been delivered to the Optionee and is hereby

                                        6

<PAGE>

CUSIP No.   024611-10-5            13D             Page  28   of   36 Pages     
- --------------------------------------------------------------------------------

incorporated  by reference.  In the event of any  discrepancy  or  inconsistency
between this Agreement and the Plan, the terms of the Plan shall govern.


                  15.  Enforceability.  This Agreement shall be binding upon the
Optionee, his estate, his personal representatives and beneficiaries.

                  IN WITNESS  WHEREOF,  the Company has caused this Agreement to
be duly  executed by one of its  officers  thereunto  duly  authorized,  and the
Optionee  has  hereunto  set his hand,  all as of the day and year  first  above
written.


                                       AMERICAN BIOGENETIC SCIENCES, INC.      
                                                                               
                                                                               
                                                                               
                                       By: /s/ Timothy J. Roach                
                                           --------------------------------
                                               Timothy J. Roach                
                                       Title: Secretary-Treasurer              
                                                                               
                                                                               
                                                                               
                                       Optionee:                               
                                                                               
                                          /s/  Alfred J. Roach                 
                                        -----------------------------------    
                                               Alfred J. Roach   



                                       7


CUSIP No.   024611-10-5            13D             Page  29   of   36 Pages     
- --------------------------------------------------------------------------------

                                                                       Exhibit 4
                                                                       ---------


                       AMERICAN BIOGENETIC SCIENCES, INC.
                       ---------------------------------
                        INCENTIVE STOCK OPTION AGREEMENT
                        --------------------------------


         OPTION  AGREEMENT  made this 1st day of June,  1995,  between  AMERICAN
BIOGENETIC SCIENCES,  INC. ("Company"),  and Alfred J. Roach, an employee of the
Company ("Optionee"), residing at 1365 Akron Street, Copiague, New York 11726.

                              W I T N E S S E T H :

                  WHEREAS,  the Company  desires,  by affording  the Optionee an
opportunity to purchase its common stock, $.001 par value per share (the "Common
Stock"),  as  hereinafter  provided,  to carry out the purposes of the Company's
Stock Option Plan (the "Plan"):

                  NOW,  THEREFORE,  in  consideration of the premises and of the
mutual promises hereinafter contained, the parties hereto agree as follows:

                  1. Grant of Option.  The Company hereby grants to the Optionee
an option  ("Option")  to purchase  all or any part of an  aggregate  of 135,000
shares of Common Stock (such number being  subject to  adjustment as provided in
Section 9 hereof) on the terms and conditions  hereinafter set forth. The Option
is intended to be an "incentive  stock option" as defined in Section 422A of the
Internal Revenue Code of 1986 or any corresponding  provisions of succeeding law
(the "Code").

<PAGE>

CUSIP No.   024611-10-5            13D             Page  30   of   36 Pages     
- --------------------------------------------------------------------------------



                  2. Purchase Price.  The purchase price of the shares of Common
Stock covered by the Option shall be $1.925 per share of Common Stock,  which is
not less than one hundred and ten percent  (l10%) of the fair market  value of a
share of Common Stock on the date hereof.  Payment shall be made in cash,  check
or in shares of Common Stock in the manner prescribed in Section 10 hereof.

                  3.  Term of  Option.  The  term of the  Option  shall be for a
period of five (5) years from the date hereof, subject to earlier termination as
provided in Sections 6, 7 and 8 hereof.

                  4. Exercisability.  The Option may be exercised in whole or in
part at any time and from time to time prior to the  termination  of the Option,
as to all or any of the shares of Common Stock purchasable hereunder;  provided,
however,  that no shares of Common Stock  covered by the Option may be purchased
within the first six  months'  period  after the date  hereof,  and that in each
subsequent six months'  period during the term of the option,  the holder of the
Option may  purchase a number of shares of Common  Stock equal to one quarter of
the total number of shares  subject to the option  until one hundred  percent of
the Option shall be exercisable  two (2) years after the date thereof.  If fewer
than the number of available  shares are purchased under the Option,  the holder
may purchase any such  unpurchased  shares during the term of the Option.  In no
event shall the Option be exercised  after the expiration of five (5) years from
the date hereof.


                                        2

<PAGE>

CUSIP No.   024611-10-5            13D             Page  31   of   36 Pages     
- --------------------------------------------------------------------------------

                  Except as provided in Sections 6, 7 and 10 hereof,  the Option
may not be  exercised  at any time unless the  Optionee  shall then be and shall
have been, at all times from the date of grant of the Option, an employee of the
Company or of a subsidiary  of the Company.  The term  "employee"  shall include
officers and  directors  who are  employees  of the  Company.  The holder of the
Option  shall not have any of the rights of a  shareholder  of the Company  with
respect to the shares of Common  Stock  covered by the Option  until one or more
certificates  for such shares of Common Stock shall have been issued to him upon
the due exercise of the Option.

                  5.  Non-transferability.  The Option shall not be transferable
otherwise than by will or the laws of descent and  distribution,  and the Option
may be  exercised  during  the  lifetime  of the  Optionee  only  by  him,  more
particularly (but without limiting the generality of the foregoing),  the Option
may  not be  assigned,  transferred  (except  as  provided  above),  pledged  or
hypothecated  in any way, shall not be assignable by operation of law, and shall
not be subject to  execution,  attachment,  or similar  process.  Any  attempted
assignment,  transfer, pledge,  hypothecation or other disposition of the Option
contrary to the provisions hereof, and the levy of any execution, attachment, or
similar process upon the Option, shall be null and void and without effect.


                                       3
<PAGE>

CUSIP No.   024611-10-5            13D             Page  32   of   36 Pages     
- --------------------------------------------------------------------------------

                  6. Employment.  The granting of the Option is in consideration
of the Optionee's continuing employment by the Company; however, nothing in this
Option shall confer upon the Optionee the right to continue in the employment of
the  Company or affect  the right of the  Company to  terminate  the  Optionee's
employment at any time in its sole discretion, with or without cause.

                  In the event that the  Optionee  shall cease to be so employed
for any reason other than death,  retirement  with the consent of the Company or
disability (as  determined by the committee  appointed by the Board of Directors
of the Company to administer the Plan (the "Committee") in its sole discretion),
the Option shall terminate on the date of termination of employment or on a date
not more than three (3) months after such date of  termination of employment (as
determined by the Committee it its sole discretion);  provided, however, that in
the event of exercise after termination of employment, the Optionee shall not be
entitled  to  purchase  any  shares of Common  Stock in excess of the  number of
shares  which he would have been  permitted  to  purchase  upon  exercise of the
Option on his date of termination. If the Optionee is disabled (as determined by
the  Committee  in its sole  discretion)  or  retires  with the  consent  of the
Company,  the Option shall  terminate  one (1) year after the date of disability
and not later than three (3) months after the date of retirement  (as determined
by the Committee in its sole discretion).

                                       4
<PAGE>

CUSIP No.   024611-10-5            13D             Page  33  of   36 Pages     
- --------------------------------------------------------------------------------

                  7. Death of Optionee.  If the Optionee  shall die while in the
employ of the Company or a  subsidiary  of the  Company,  his  estate,  personal
representative,  or beneficiary shall have the right,  subject to the provisions
of Section 3 hereof,  to exercise  the Option (to the extent  that the  Optionee
would have been  entitled  to do so at the date of his death) at any time within
one (1) year from the date of his death.

                  8.  Termination of Option.  In the event of the institution of
any legal proceedings directed to the validity of the Plan pursuant to which the
Option is granted,  or to any option  granted  under it, the Company may, in its
sole discretion, and without incurring any liability therefor to the Optionee or
any other person, terminate the Option.

                  9. Stock  Splits,  Mergers,  Etc. In case of any stock  split,
stock dividend or similar transaction which increases or decreases the number of
outstanding shares of Common Stock,  appropriate adjustment shall be made by the
Board of Directors,  whose determination shall be final, to the number of shares
of Common Stock which may be purchased  under the Plan and the number and option
exercise price per share which may be purchased under any  outstanding  options.
In the case of a merger,  sale of assets or similar transaction which results in
a  replacement  of the  Company's  shares of Common  Stock with stock of another
corporation,  the  Company  will  make a  reasonable  effort,  but  shall not be
required, to replace any outstanding options with comparable options to purchase
the stock of such other 


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corporation,  or will provide for immediate maturity of all outstanding options,
with all options not being  exercised  within the time period  specified  by the
Board of Directors being terminated.

                  10.  Method of  Exercising  Option.  Subject  to the terms and
conditions  of this Option  Agreement,  the Option may be  exercised  by written
notice to the Company as  provided  in Section  11. Such notice  shall state the
election  to  exercise  the Option  and the number of shares of Common  Stock in
respect  of which it is being  exercised.  It shall be signed  by the  person or
persons so exercising the Option and shall be accompanied by payment of the full
purchase  price  of  such  shares  in  cash,  by  check  or by the  delivery  of
certificates  representing  shares of Common  Stock  with fully  executed  stock
powers,  and the  Company  shall  issue,  in the name of the  person or  persons
exercising the Option,  and deliver a certificate or  certificates  representing
such shares of Common Stock as soon as practicable  after the notice and payment
have been received.

                  In the event the Option  shall be  exercised  by any person or
persons other than the Optionee, pursuant to Section 7 hereof, such notice shall
be accompanied  by  appropriate  proof of the right of such person or persons to
exercise the Option. All shares of Common Stock that shall be purchased upon the
exercise   of  the  Option  as   provided   herein   shall  be  fully  paid  and
non-assessable.


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CUSIP No.   024611-10-5            13D             Page  35   of   36 Pages     
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                  11. General. The Company shall at all times during the term of
the Option  reserve and keep  available such number of shares of Common Stock as
will be sufficient to satisfy the requirements of this Agreement,  shall pay all
taxes with  respect to the issue of shares of Common Stock  pursuant  hereto and
all other fees and expenses  necessarily  incurred by the Company in  connection
therewith,  and will, from time to time, use its best efforts to comply with all
laws and regulations which, in the opinion of counsel for the Company,  shall be
applicable thereto.

                  12.  Representation of Optionee.  The Optionee represents that
he and any related  persons or entities,  within  Section 425(d) of the Code, do
not own as much as ten percent (l0%) of the total combined voting power or value
of all capital stock of the Company,  or any  subsidiary of the Company,  and in
accepting the option herein granted to him, agrees to the terms of the Option on
the date hereof.

                  13.  Notices.  Each notice  relating to this Option  Agreement
shall be in writing and  delivered  in person or by first  class  mail,  postage
prepaid,  to the proper address.  Each notice shall be deemed to have been given
on the date it is received.  Each notice to the Company shall be addressed to it
at its principal office (Attention:  Treasurer).  Each notice to the Optionee or
other person or persons then  entitled to exercise the Option shall be addressed
to the  Optionee or such other person or persons at the  Optionee's  address set
forth in the  heading  of this  Agreement.  Anyone to whom a notice may be given
under this

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CUSIP No.   024611-10-5            13D             Page  36   of   36 Pages     
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 Agreement may designate a new address by notice to that effect.

                  14.  Incorporation  of Plan.  Notwithstanding  the  terms  and
conditions  herein,  any Option  granted  pursuant  to this  Agreement  shall be
subject to and governed by all the terms and  conditions  of the Plan. A copy of
the Plan has been  delivered  to the  Optionee  and is  hereby  incorporated  by
reference.  In the  event  of any  discrepancy  or  inconsistency  between  this
Agreement and the Plan, the terms of the Plan shall govern.

                  15.  Enforceability.  This Agreement shall be binding upon the
Optionee, his estate, his personal representatives and beneficiaries.

                  IN WITNESS  WHEREOF,  the Company has caused this Agreement to
be duly  executed by one of its  officers  thereunto  duly  authorized,  and the
Optionee  has  hereunto  set his hand,  all as of the day and year  first  above
written.

                                     AMERICAN BIOGENETIC SCIENCES, INC.



                                     By: /s/ Timothy J. Roach
                                         ------------------------------------
                                             Timothy J. Roach
                                     Title: Secretary-Treasurer
                                              


                                     Optionee:
                                    
                                        /s/  Alfred J. Roach
                                      -----------------------------------
                                             Alfred J. Roach





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