AMERICAN BIOGENETIC SCIENCES INC
S-3/A, 1999-04-15
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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     As filed with the Securities and Exchange Commission on April 14, 1999

                           Registration No. 333-69735

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                           --------------------------
   
                                 AMENDMENT NO. 1
                                       TO
                                    FORM S-3
                             REGISTRATION STATEMENT
                                      Under
                           The Securities Act of 1933

                           --------------------------
    

                       AMERICAN BIOGENETIC SCIENCES, INC.
             (Exact Name of Registrant as Specified In Its Charter)

               Delaware                               11-2655906
      (State or Other Jurisdiction of                 (I.R.S. Employer
      Incorporation or Organization)                  Identification Number)

                      1375 Akron Street, Copiague, NY 11726
          (Address, Including Zip Code, and Telephone Number, Including
             Area Code, of Registrant's Principal Executive Offices)

                           --------------------------

                             RICHARD A. RUBIN, ESQ.
                       PARKER CHAPIN FLATTAU & KLIMPL, LLP
                           1211 Avenue of the Americas
                            New York, New York 10036
                                 (212) 704-6000
            (Name, Address, Including Zip Code, and Telephone Number,
                   Including Area Code, of Agent for Service)

                           --------------------------

         Approximate  date of  commencement  of proposed sale to the public:  As
soon as practicable after the effective date of this Registration Statement.

         If the only securities  being registered on this Form are being offered
pursuant to dividend or interest  reinvestment plans, please check the following
box.

         If any of the  securities  being  registered  on  this  Form  are to be
offered  on a  delayed  or  continuous  basis  pursuant  to Rule 415  under  the
Securities Act of 1933,  other than  securities  offered only in connection with
dividend or interest reinvestment plans, check the following box: X

         If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list  the  Securities  Act  registration  statement  number  of the  earlier
effective registration statement for the same offering.

         If this  Form is a  post-effective  amendment  filed  pursuant  to Rule
462(c) under the Securities Act, check the following box and list the Securities
Act  registration   statement  number  of  the  earlier  effective  registration
statement for the same offering.

         If delivery of the  prospectus  is expected to be made pursuant to Rule
434, please check the following box.

         The registrant hereby amends this  registration  statement on such date
or dates as may be necessary to delay its  effective  date until the  registrant
shall file a further amendment which specifically  states that this registration
statement shall  thereafter  become effective in accordance with Section 8(a) of
the  Securities  Act of 1933 or until the  registration  statement  shall become
effective on such date as the Commission,  acting pursuant to said Section 8(a),
may determine.                                                               

<PAGE>



The  information in this  prospectus is not complete and may be changed.  We may
not sell  these  securities  until the  registration  statement  filed  with the
Securities and Exchange Commission is effective. This prospectus is not an offer
to sell nor is it seeking an offer to buy these  securities  in any state  where
the offer or sale is not permitted.
   
                 SUBJECT TO COMPLETION, DATED APRIL ____, 1999

PROSPECTUS
- -----------
                                10,800,000 Shares

                       American Biogenetic Sciences, Inc.

                              Class A Common Stock
                               -------------------

         The stockholders of American Biogenetic  Sciences,  Inc. listed on page
10 of this prospectus are offering for sale 10,800,000  shares of class A common
stock of ABS under this prospectus.

         The selling  stockholders  may offer  their  shares  through  public or
private  transactions,  at prevailing market prices, or at privately  negotiated
prices. See "Plan of Distribution."

                        -------------------------------

                         Nasdaq National Market Symbol:
                                     "MABXA"

                        -------------------------------

         On April 9, 1999,  the  closing  price of a share of our class A common
stock on the Nasdaq National Market was $ 1.09.

                          ----------------------------


         This  investment  involves a high degree of risk. You should  carefully
         consider  the  factors  described  under  the  caption  "risk  factors"
         beginning on page 3 of this prospectus.

         Neither the Securities and Exchange Commission nor any state securities
         commission has approved or disapproved these securities,  or determined
         if this prospectus is truthful or complete.  Any  representation to the
         contrary is a criminal offense.

                          ----------------------------

                   The date of this prospectus is ______, 1999

    
<PAGE>

   

                               PROSPECTUS SUMMARY

         This summary  highlights some information from this prospectus.  It may
not contain all of the information important to you. To understand this offering
fully and get a better understanding of our business and operations,  you should
read the  entire  prospectus  carefully,  including  the risk  factors,  and the
documents we have  incorporated  by reference in the section "Where You Can Find
More Information About Us."

         Please note that  references in this  prospectus to "we," "our" or "us"
refer to American  Biogenetic  Sciences,  Inc. and our  subsidiary,  Stellar Bio
Systems, Inc., not to the selling stockholders.

                          General Information About ABS

         We are engaged in researching,  developing and marketing cardiovascular
and neurobiology products for commercial  development.  We commenced selling our
products during the last quarter of 1997.

         Some of our products are designed to be used for in vivo,  while others
are designed for in vitro, diagnostic procedures.  In vivo diagnostic procedures
are those in which proteins or compounds are injected  directly into the body or
bloodstream  to  assess  abnormal  reactions  or  conditions.  During  in  vitro
procedures,  blood,  urine or other bodily fluid or tissue is extracted from the
body and the diagnostic  tests are performed in a test tube or other  laboratory
equipment.

         Our main products are:

         o    Thrombus Precursor Protein test,  referred to as the TpP(TM) test.
              This is an in vitro  diagnostic  test used to  assess  the risk of
              blood  clots in the veins or  arteries.  This test is also used to
              monitor the performance of anti-clotting  therapy or drugs used in
              the prevention of blood clots.

         o    Functional  Intact  Fibrinogen  test,  referred  to as the FiF(TM)
              test.  This is an in vitro  diagnostic  test  which  measures  the
              levels of fibrinogen in blood. Fibrinogen is a protein used in the
              blood-clotting process.

         These tests  assist  doctors in  diagnosing  and  treating  blood clots
lodged in the legs and the lungs, known as thrombosis,  a condition which can be
fatal.  Thrombosis is also associated with many other medical  conditions,  like
heart attacks, strokes and complications during pregnancies. We are pursuing the
application of our tests in these areas with  additional  clinical  testing.  We
have also  developed  patented  antibodies  for use in our  TpP(TM)  and FIF(TM)
tests.

         On April 23,  1998,  we  purchased  all of the issued  and  outstanding
shares  of common  stock of  Stellar  Bio  Systems,  Inc.,  a  manufacturer  and
distributor of in vitro  diagnostic  products and research  reagents used in the
biotechnology industry. A reagent is a chemical substance used to detect another
substance in a chemical reaction.  Stellar's in vitro diagnostic  products focus
on the infectious  disease and auto-immune  disease  markets.  Stellar markets a
complete  line of  products to  determine  the immune  status of numerous  human
herpes viruses.  In addition,  auto-immune  diseases,  like lupus,  are detected
using  Stellar's  products.  Stellar is also the  largest  domestic  provider of
normal  mouse  serum,  which  is used as a test  component  by  major  in  vitro
diagnostic product manufacturers for a variety of purposes.

         Our  company  was  incorporated  in Delaware  in  September  1983.  Our
principal executive offices are located at 1375 Akron Street, Copiague, New York
11726, and our telephone number at that address is (516) 789-2600.

         We have 36,023,841  shares class A common stock and 3,000,000 shares of
class B common stock outstanding.  This offering will not result in the issuance
of additional shares.
    
                                      - 2 -

<PAGE>

   

                                  RISK FACTORS

         Before you buy shares of our class A common stock,  you should be aware
that there are various risks  associated  with that  purchase,  including  those
described below. You should consider carefully these risk factors, together with
all of the  other  information  in this  prospectus  and the  documents  we have
incorporated  by reference in the section  "Where You Can Find More  Information
About Us", before you decide to purchase shares of our class A common stock.

              ----------------------------------------------------
              Risks Associated with Our Lack of Operating History,
                  History of Losses and Future Need for Capital
              ----------------------------------------------------

We Are In The  Development  Stage And Cannot  Anticipate  When We Will  Generate
Significant Revenues.

         ABS remains in the  development  stage.  Although  we have  products at
various stages of development and have started to generate  revenues,  we cannot
assure you as to if and when we may begin generating  significant  revenues from
product sales and cease being a development stage company. We have not generated
significant  revenues  from  product  sales from our  inception to date and have
incurred  losses every year since our  formation in 1983.  Through  December 31,
1998, we have received an aggregate of $1,302,000 in licensing  fees,  royalties
and under  collaborative  agreements.  Sales of the TpP(TM)  and FIF(TM)  tests,
which  commenced  during the  fourth  quarter  of 1997,  and sales of  Stellar's
products since its  acquisition on April 23, 1998,  totaled  $1,347,000  through
December 31, 1998.

We Have A History And Expectation of Losses.

         Our research, development, and general and administrative expenses have
resulted  in  significant  losses  and are  expected  to  continue  to result in
significant losses for the foreseeable future.
We have incurred the following losses since 1994:


Fiscal year ended:
         o  December 31, 1994..................... $7,431,000
         o  December 31, 1995..................... $5,607,000
         o  December 31, 1996..................... $7,700,000
         o  December 31, 1997..................... $7,147,000
         o  December 31, 1998..................... $7,548,000


The Cycle From Product Development To Commercialization Is Lengthy
And May Result in Delays In The Commercialization Of Our Products
    

         Our existing products and our products under development are subject to
the risks inherent in the development of biotechnology  products.  We are unable
to predict  with any  degree of  certainty  when,  or if, we will  complete  the
research, development and testing of products under development and other future
products, or if completed, whether we will obtain required regulatory approvals.
In addition,  we cannot assure you that once our products are developed,  tested
and  approved,  that  we will be able to  produce  our  products  in  commercial
quantities  at  reasonable  costs,  that our products  will be acceptable to the
medical community, or that our marketing and sales efforts will be successful.

                                      - 3 -

<PAGE>
   


We Will Likely Need Additional Financing To Commercialize Our Products.

         The  research,   development,   commercialization,   manufacturing  and
marketing of our products  will likely  require  financial  resources  which are
significantly in excess of those presently available to us.
 We cannot  assure you that we will be able to arrange  financing or other third
party   arrangements  on  acceptable   terms  necessary  to  fully  develop  and
commercialize any of our products.

             ------------------------------------------------------
             Risks Associated with the Industry in Which We Operate
             ------------------------------------------------------

Our Products Are Highly Regulated.

         The  investigation,  manufacture,  exportation,  marketing  and sale of
diagnostic and  therapeutic  products in or from the United States is subject to
regulation by the Food and Drug Administration, as well as by comparable foreign
and state agencies.  Although we have obtained pre-market  clearance for some of
our existing products, we cannot assure you that any of our future products will
be approved by the FDA or other applicable foreign regulatory agencies. Any FDA,
foreign and state  regulatory  approvals or clearances,  once  obtained,  can be
withdrawn  or modified.  Our  inability to obtain and  maintain,  any  necessary
United States or foreign clearances or manufacturing and marketing approvals for
our products  could have a material  adverse  effect on our business,  financial
condition and results of operations. In addition,  noncompliance with applicable
government  requirements can result in, among other things, fines,  injunctions,
civil penalties,  recall or seizure of products,  total or partial suspension of
production,   failure  of  the  government  to  grant  pre-market  clearance  or
pre-market  approval for  devices,  withdrawal  of  marketing  or  manufacturing
approvals, and criminal prosecutions.

Our Main Competitors Generally Have More Financial Resources Than We Have.

         The  biotechnology  industry is  characterized  by rapid  technological
advances,  evolving  industry  standards  and  technological  obsolescence.  Our
inability to meet and surpass our  competitors'  technological  advances,  could
have a material adverse effect on our business,  financial condition and results
of operations.

         We have numerous  competitors,  none of whom we believe to be dominant,
but who have  financial  resources  and  research  and  development  staffs  and
facilities  substantially  greater  than ours.  Our  competitors  and others may
develop products which may render our products obsolete or which have advantages
over our products,  such as greater accuracy and precision or greater acceptance
by the medical community. Competing products may also get through the regulatory
approval  process sooner than our products,  enabling our  competitors to market
their  products  earlier  than we can.  Usually,  the  first  person to market a
product has a significant marketplace advantage. In addition, other products now
in  use,  presently   undergoing  the  regulatory  approval  process,  or  under
development by others, may perform similar functions as our existing products or
those under development.

Acceptance By The Medical Community is Essential To Our Future Success.

         The commercial  success of our products is  substantially  dependent on
acceptance  and use of our products by the medical  community.  We cannot assure
you that any of our products will be accepted by the medical  community,  or, if
acceptable,  as to the  length  of  time  it  would  take  to  gain  acceptance.
Widespread  acceptance of our products as useful  additional  tools to diagnosis
and treatment will require  educating the medical  community about the product's
benefits, reliability and effectiveness. In addition, acceptance of our products
may be  adversely  affected  by  competing  products  which  may  be as or  more
effective than our products for a specific use.
    
                                      - 4 -

<PAGE>


   
We May Have Increased Expenses If Our Marketing Efforts Are Not Successful.

         It is our  strategy  to seek  arrangements  with  large  pharmaceutical
companies to market our products. In the event we are unable to enter into those
arrangements in the future or if our  arrangements  are not  successful,  we may
seek to  market  our  products  through  independent  distributors.  Independent
distributors may require us to develop a marketing  program to support sales. In
that event, we may incur additional  expenses for the development of promotional
literature and aides, the hiring of sales  representatives and the completion of
studies in order to promote the interests of  distributors  in our products.  We
cannot assure you that we will be able to develop those  marketing  arrangements
on satisfactory  terms or that, if necessary,  we would have the working capital
to establish the sales support generally required by independent distributors.

           ----------------------------------------------------------
           Risks Associated with Our Internal Operations and Policies
           ----------------------------------------------------------


We Do Not Intend To Declare Dividends in the Foreseeable Future.

          Our board of directors does not intend to declare any dividends in the
foreseeable  future, but intends to retain all earnings,  if any, for use in our
business  operations.  The  holders  of  class A and  class B common  stock  are
entitled to receive dividends when, as and if declared by the board of directors
out of funds legally available for dividend payments.  To date, we have not paid
any cash  dividends.  The payment of dividends,  if any, in the future is within
the  discretion  of our board of  directors  and will depend upon our  earnings,
capital requirements and financial condition, and other relevant factors.

We Depend On the Services of Our Key Personnel.

         Our  success  depends to a  significant  extent upon the efforts of (1)
Alfred J. Roach,  the  Chairman of our board of  directors  and one of our major
stockholders,  (2) Mr. John S. North, our President and Chief Executive Officer,
and (3) Dr. Emer  Leahy,  our Senior Vice  President-Business  Development.  Mr.
Roach is not subject to any employment agreement.  Our employment agreement with
Mr. North  expires on November 15, 2001 and our  employment  agreement  with Dr.
Leahy  expires on November 30, 2001.  We do not maintain  life  insurance on the
lives of Mr.  Roach,  Mr.  North or Dr.  Leahy.  The loss of the services of Mr.
Roach, Mr. North or Dr. Leahy could adversely affect our business and prospects.
Because of the nature of our business, our success is dependent upon our ability
to attract and retain technologically qualified personnel, particularly research
scientists. There is substantial competition for qualified personnel,  including
competition from companies with  substantially  greater  resources than ours. We
cannot  assure  you  that we will  be  successful  in  recruiting  or  retaining
personnel  of the  requisite  caliber  or in  adequate  numbers  to enable us to
conduct our business and effectively compete in our industry.

Year 2000 Issues

         Historically,  certain computerized systems have used two digits rather
than four to define the  applicable  year.  Computer  equipment and software and
devices with imbedded  technology that are  time-sensitive  may recognize a date
using  "00" as the year 1900  rather  than the year  2000,  resulting  in system
failure or  miscalculations.  This problem is generally referred to as the "Year
2000 issue."

         We are in the process of assessing the impact of the Year 2000 issue on
our information  systems.  We have  identified  potential  deficiencies  and are
addressing them through updates and  remediation.  In accordance with accounting
rules,  costs associated with modifying existing computer software for Year 2000
issues will be expensed as incurred. We are also in the process of assessing the
measures  being taken by our  customers  and  suppliers to address the Year 2000
issues and expect to have a  contingency  plan in place by the end of the second
quarter in 1999. We are not dependent on
    
                                      - 5 -

<PAGE>

   

any one customer or supplier and our management  believes that alternate sources
of supply for product  components are widely available.  We estimate the cost of
the Year 2000 to be approximately $50,000.


           ------------------------------------------------------------
           Risks Which May Dilute the Value of Your ABS Shares or Limit
                         the Effect of Their Voting Power
           ------------------------------------------------------------


No Assurance of Continued Nasdaq Listing.

         The  closing  price of our  class A common  stock on April 9,  1999 was
$1.09 and our tangible net assets, as defined under Nasdaq rules, was $5,016,000
as  of  December  31,  1998.  The  Nasdaq  National  Market  continuing  listing
parameters require that stocks have a minimum bid price of $1.00 and that listed
companies have net tangible  assets of $4,000,000.  We cannot assure you that we
will  continue  to meet these and meet other  Nasdaq  requirements  and that our
class A common  stock  will  continue  to be  quoted  on  Nasdaq.  If we fail to
maintain  a Nasdaq  listing,  our  securities  will  likely be traded on the OTC
Bulletin Board. As a result,  the market value of our class A common stock could
decline and  stockholders may find it more difficult to dispose of, or to obtain
accurate quotations as to the market value of, our class A common stock.

The Price Of Our Common Stock Is Highly Volatile.

         The price of our class A common  stock is highly  volatile.  During the
period  from  January  1,  1998 to April 9, 1999 the price of our class A common
stock  has  ranged  from a high of $2.63 in  February  1998 to a low of $0.16 in
October 1998. Following periods of volatility in the market price of a company's
securities, securities class action litigation has often been instituted against
such a company.  If similar  litigation  were  instituted  against  us, it could
result in substantial  costs and a diversion of our  management's  attention and
resources,  which could have an adverse  effect on our  business.  The  volatile
fluctuations  of the  market  price are based on (1) the number of shares in the
market at the time as well as the number of shares we may be  required  to issue
in the future,  compared to the market demand for our shares;(2) our performance
and meeting  expectations  of our  performance,  including the  development  and
commercialization  of our  products  and  proposed  products;  and  (3)  general
economic and market conditions.

ABS Is Controlled By Alfred J. Roach.

         As of March 31,  1999,  Alfred J. Roach,  the  Chairman of our board of
directors,  was entitled to cast approximately 52.4% of all votes at meetings of
stockholders  or by consent  without a meeting.  As a result,  Mr. Roach will be
able to exercise  significant  control over ABS through his ability to determine
the outcome of votes of stockholders regarding,  among other things,  nomination
and election of directors and approval of significant transactions.  Mr. Roach's
holdings of ABS may  increase in the future  through his  exercise of options to
purchase an additional 1,160,000 shares of our class A common stock which he may
exercise at any time.

We Have A Substantial Number Of Shares Reserved For Future Issuances.

         The issuance of reserved  shares  would  dilute the equity  interest of
existing  stockholders and could have a significant adverse effect on the market
price of our class A common stock. As of March 31, 1999, we had 9,516,945 shares
of class A common stock reserved for possible  future  issuances upon conversion
of the class B common stock and exercise of  outstanding  options and  warrants.
See "Dilution."
    
                                      - 6 -

<PAGE>
   


         In addition, we intend to seek additional financing which may result in
the issuance of additional  shares of our capital stock and/or rights to acquire
additional  shares of our capital stock.  Those additional  issuances of capital
would result in a reduction of your percentage interest in ABS.

A Significant Number of Restricted Shares May Be Resold Under Rule 144.

         Future sales of substantial  amounts of shares in the public market, or
the perception that those sales could occur,  could adversely  affect the market
price of our class A common  stock.  As of March 31,  1999,  we had  outstanding
36,023,841  shares  of  class  A  common  stock.  Of  our  outstanding   shares,
approximately  20,583,368  shares of class A common stock are  presently  freely
transferable  without restriction under the Securities Act and 15,440,473 shares
are "restricted  shares" which may be sold under an exemption from  registration
under the Securities Act. See "Dilution"; "Shares Eligible for Future Sale."

                INFORMATION REGARDING FORWARD-LOOKING STATEMENTS

         Some of the information in this prospectus and in the documents we have
incorporated  by  reference,  may  contain  forward-looking  statements.   Those
statements can be generally identified by the use of forward-looking  words like
"may,"  "will,"  "expect,"   "anticipate,"   "intend,"  "estimate,"  "continue,"
"believe," or other similar words. These statements discuss future expectations,
or state other "forward-looking" information. When considering those statements,
you should keep in mind the risk factors and other cautionary statements in this
prospectus.  The risk factors  noted in this section and other  factors noted in
this prospectus  could cause our actual results to differ  materially from those
contained in any forward-looking statements.

                  WHERE YOU CAN FIND MORE INFORMATION ABOUT US

         We file annual,  quarterly and special  reports,  proxy  statements and
other  information  with the SEC.  You may read and copy any document we file at
the SEC's public  reference  rooms in  Washington,  D.C., New York, New York and
Chicago,   Illinois.  Please  call  the  SEC  at  1-800-SEC-  0330  for  further
information on the public reference rooms. Our SEC filings are also available to
the public over the Internet at the SEC's Website at "http://www.sec.gov."

         We have  filed  with the SEC a  registration  statement  on Form S-3 to
register the shares being offered.  This prospectus is part of that registration
statement  and,  as  permitted  by the SEC's  rules,  does not  contain  all the
information included in the registration statement. For further information with
respect to us and our class A common stock, you should refer to the registration
statement  and to the exhibits and schedules  filed as part of the  registration
statement, as well as the documents discussed below.

         The SEC allows us to "incorporate by reference" the information we file
with them,  which means that we can  disclose  important  information  to you by
referring you to those documents.  The information  incorporated by reference is
an important part of this  prospectus,  and information  that we file later with
the SEC will automatically update or supersede this information.

         This prospectus may contain  summaries of contracts or other documents.
Because they are summaries,  they will not contain all of the  information  that
may be important to you. If you would like complete information about a contract
or  other  document,  you  should  read  the copy  filed  as an  exhibit  to the
registration   statement  or  incorporated  in  the  registration  statement  by
reference.

         We incorporate  by reference the documents  listed below and any future
filings we will make with the SEC under Sections  13(a),  13(c),  14 or 15(d) of
the Securities Exchange Act of 1934 (File No.
0-19041) until all of the shares are sold:

    
                                      - 7 -

<PAGE>

   

          o       Annual Report on  Form 10-K  for  the  year ended December 31,
                  1998; and

          o       The  description of our class A common stock  contained in the
                  registration statement on Form 8-A filed on February 26, 1991,
                  including  all  amendments or reports filed for the purpose of
                  updating that description.

         You may  request a copy of these  filings,  at no cost,  by  writing or
telephoning us at the following address:

                             Chief Financial Officer
                             American Biogenetic Sciences, Inc.
                             1375 Akron Street
                             Copiague, New York 11726
                             (516) 789-2600



         You can review and copy the  registration  statement,  its exhibits and
schedules,  as well as the  documents  listed  below,  at the  public  reference
facilities maintained by the SEC as described above. The registration statement,
including its exhibits and schedules, are also available on the SEC's web site.



                                 USE OF PROCEEDS

         The selling  stockholders are selling all of the shares covered by this
prospectus for their own account.  Accordingly, we will not receive any proceeds
from the resale of the shares.

         We received  $2,700,000  in proceeds from our sale of the shares to the
selling  stockholders.  We used the proceeds,  together  with  $1,152,000 of our
funds, to repurchase:

         o        the remaining 5%  convertible  debentures  with an outstanding
                  principal amount of $3,248,000 plus interest and a 16% premium
                  of the principal amount; and

         o        outstanding warrants to purchase 261,228 of our class A common
                  stock at an exercise price of $1.9141 per share.

         We will bear the  expenses  relating to this  registration,  other than
discounts and commissions, which will be paid by the selling stockholders.



                                    DILUTION



         As of March 31, 1999, we had issued and outstanding  36,023,841  shares
of class A common stock.

         At that date,  there  were an  additional  9,516,945  shares of class A
common stock reserved for possible future issuances as follows:

                 o         3,000,000  shares for issuance upon conversion of the
                           outstanding class B common stock;

    

                                      - 8 -

<PAGE>

   

                  o        2,775,000  shares for  issuance  upon the exercise of
                           outstanding options under our 1986 Stock Option Plan.
                           These options are  exercisable at prices ranging from
                           $1.50 to $10.00 per share;

                  o        1,995,000  shares for  issuance  upon the exercise of
                           presently outstanding options or options which may be
                           granted  in the future  under our 1996  Stock  Option
                           Plan.  Options  to  purchase  1,621,084  shares  were
                           outstanding  at March 31,  1999.  These  options  are
                           exercisable at prices ranging from $0.25 to $5.25 per
                           share;

                  o        487,500  shares for  issuance  upon the  exercise  of
                           presently outstanding options or options which may be
                           granted  in the  future  under our 1993  Non-Employee
                           Director  Stock  Option  Plan.  Options  to  purchase
                           120,000  shares were  outstanding  at March 31, 1999.
                           These options are  exercisable at prices ranging from
                           $1.00 to $6.75 per share; and

                  o        1,259,445  shares for issuance upon exercise of other
                           outstanding warrants and options held by unaffiliated
                           third   parties.   These  warrants  and  options  are
                           exercisable at prices ranging from $0.75 to $4.25 per
                           share.

                         SHARES ELIGIBLE FOR FUTURE SALE

         Of the  36,023,841  shares of class A common  stock  outstanding  as of
March  31,  1999,   approximately   20,583,368   shares  are  presently   freely
transferable without restriction under the Securities Act.

         Of the remaining 15,440,473 outstanding shares of class A common stock:

         o        10,800,000  are  "restricted  securities",  issued in  October
                  1998, which are covered by this prospectus.  These shares will
                  be freely tradeable without  restriction on the effective date
                  of the registration statement;

         o        619,723  shares are  "restricted  securities"  issued  between
                  February 1997 and March 1999; and

         o        4,020,750  shares are held by persons  who may be deemed to be
                  our "affiliates".  Of these shares,  1,974,500 are "restricted
                  securities"  issued between  November 1997 and March 1999. The
                  remaining   2,046,250   of  those   shares   are   "restricted
                  securities"  that were acquired more than two years ago or are
                  not "restricted  securities" because they were acquired in the
                  market or under a registration  statement under the Securities
                  Act.

         "Restricted   securities"  and  unrestricted  securities  held  by  our
affiliates may be sold:

                  (1)     under  a  prospectus  under  an effective registration
                          statement under the Securities Act,

                  (2)     in  compliance  with  the exemption provisions of Rule
                          144, or

                  (3)     under another exemption under the Securities Act.

         Rule  144  permits  sales of  "restricted  securities"  by any  person,
whether or not an  affiliate,  after one year.  At that time,  sales can be made
subject  to the  Rule's  volume  and  other  limitations  and after two years by
non-affiliates  without  adhering  to Rule  144's  volume or other  limitations.
Shares of our

    
                                      - 9 -

<PAGE>
   


class A  common  stock  owned  by our  "affiliates"  which  are not  "restricted
securities"  may be sold at any time by  complying  with Rule  144's  volume and
other limitations.

         In  general,  an  "affiliate"  is a person with the power to manage and
direct our policies. The SEC has stated that, generally,  executive officers and
directors of an entity are deemed affiliates of the entity.

         In addition, all shares issuable upon the exercise of options under our
stock option plans have been  registered  under the  Securities Act for issuance
and, unless held by our "affiliates",  will be freely tradable upon issuance. If
acquired by our  "affiliates,"  shares issued upon the exercise of those options
could  be sold at any  time by  complying  with  Rule  144's  volume  and  other
limitations  unless  covered by a  registration  statement and  prospectus  that
permits  their  sale  without  those  limitations.   To  date,  no  registration
statements  have been filed with  respect  to the  resale of those  shares.  See
"Dilution."

                              SELLING STOCKHOLDERS

         We issued the shares of class A common stock covered by this prospectus
to  the  selling  stockholders  on  October  27,  1998  in a  private  placement
transaction.  Under the terms of the  private  placement,  we issued  10,800,000
shares of class A common stock to the selling  stockholders  at a price of $0.25
per  share.  At the time of the  issuances,  the  price per share of our class A
common stock was $0.19.  We agreed to register the shares  issued in the private
placement under the Securities Act at our expense,  other than selling discounts
and commissions.

         The   following   table  lists   information   regarding   the  selling
stockholders'  ownership  of shares of our class A common  stock as of March 31,
1999, and as adjusted to reflect the sale of the shares.

         Information concerning the selling stockholders, their pledgees, donees
and other non-sale transferees who may become selling  stockholders,  may change
from  time to time.  To the  extent  the  selling  stockholders  or any of their
representatives  advises us of such  changes,  we will report those changes in a
prospectus supplement to the extent required. See "Plan of Distribution."
<TABLE>
<CAPTION>

                                                                                             Shares of Class A     
                                                                                               Common Stock        
                                                                                           Beneficially Owned After
                                                    Shares of                                   the Offering       
                                                      Common                                    ------------       
                                                       Stock             Shares of      ----------------------------    
                                                    Owned Prior            Common       
                                                      to the           Stock to be     
                       Name                          Offering               Sold         Number           Percent
                       -----                         --------               ----         ------           -------              
<S>                                             <C>                 <C>                <C>              <C>
Alfred J. Roach.................................   8,735,250 (1)         4,000,000       4,735,250 (1)      12%

Larry Kupferberg................................     400,000 (2)           400,000               0 (2)       *

Donehew Fund Limited Partnership................         240,000           240,000               0           *

David Biggs.....................................          40,000            40,000               0           *

Robert Donehew..................................          80,000            80,000               0           *

R. Dave Garwood.................................          40,000            40,000               0           *

The Rachel Beth Heller 1997 Trust Lawrence
  Kupferberg, TTEEU/A dtd 7/9/97................         400,000           400,000               0           *

    
                                     - 10 -

<PAGE>
   
                                                                                             Shares of Class A     
                                                                                               Common Stock        
                                                                                           Beneficially Owned After
                                                    Shares of                                   the Offering       
                                                      Common                                    ------------       
                                                       Stock             Shares of      ----------------------------    
                                                    Owned Prior            Common       
                                                      to the           Stock to be     
                       Name                          Offering               Sold         Number           Percent
                       -----                         --------               ----         ------           -------               

The Evan Todd Heller 1997 Trust Lawrence      
   Kupferberg, TTEE U/A dtd 6/17/97.............        400,000           400,000               0           *

Delaware Charter Guarantee &Trust
   Company F/B/O Ronald I. Heller - IRA.........    642,075 (3)           600,000          42,075(3)        *

Delaware Charter Guarantee & Trust
   Company F/B/O David S. Nagelberg - IRA.......  1,242,075 (4)         1,200,000          42,075 (4)       *

Tyler Runnels...................................        292,700           280,000          12,700           *

Kevin Charos & Anthony Charos JTTEN.............        200,000           200,000               0           *

Delaware Charter Guarantee & Trust
   Company F/B/O Martin H. Meyerson - IRA.......        100,000           100,000               0           *

Kenneth Koock...................................        120,000           120,000               0           *

Jacqueline Knapp................................        790,000           790,000               0           *

Janice Halle-Nesses.............................        790,000           790,000               0           *

John Davies.....................................        160,000           160,000               0           *

Invest, Inc.....................................        160,000           160,000               0           *

Peter Janssen...................................        800,000           800,000                  0        *
                                                        -------           -------  -----------------
         Total                                       15,632,100        10,800,000       4,832,100

</TABLE>


* Less than 1%

(1)      Includes  3,000,000  shares  of  class A  common  stock  issuable  upon
         conversion of currently  outstanding class B common stock and 1,160,000
         shares of class A common  stock  issuable  upon  exercise of  presently
         exercisable options.

(2)      Does not include  400,000  shares of class A common stock  beneficially
         owned by the Evan Todd Heller 1997 Trust and 400,000  shares of class A
         common stock  beneficially  owned by the Rachel Beth Heller 1997 Trust,
         which are listed  separately  below.  Mr.  Kupferberg is the trustee of
         those trusts.

    
                                     - 11 -

<PAGE>

   

(3)      Includes  42,075 shares of class A common stock  issuable upon exercise
         of presently  exercisable  warrants  beneficially  owned by Mr. Heller.
         Those warrants are exercisable at $.075 per share.

(4)      Includes  42,075 shares of class A common stock  issuable upon exercise
         of presently  exercisable warrants beneficially owned by Mr. Nagelberg.
         Those warrants are exercisable at $.075 per share.

         Each of Messrs. Heller, Nagelberg,  Koock and Meyerson are employees of
M.H. Meyerson, one of our financial advisors since August 1998.

                              PLAN OF DISTRIBUTION

         The selling  stockholders and their pledgees,  donees,  transferees and
other subsequent  owners, may offer their shares at various times in one or more
of the following transactions:

         o         in the over-the-counter market; or

         o         in privately negotiated transactions

at  prevailing  market  prices at the time of sale,  at prices  related to those
prevailing market prices, at negotiated prices or at fixed prices.

         The  selling  stockholders  may also  sell the  shares  under  Rule 144
instead of under this prospectus, if Rule 144 is available for those sales.

         The  transactions  in the  shares  covered  by this  prospectus  may be
effected by one or more of the following methods:

         o        ordinary brokerage  transactions and transactions in which the
                  broker solicits purchasers;

         o        purchases by a broker or dealer as  principal,  and the resale
                  by  that  broker  or  dealer  for  its   account   under  this
                  prospectus, including resale to another broker or dealer;

         o        block  trades in which the  broker or dealer  will  attempt to
                  sell the shares as agent but may position and resell a portion
                  of  the  block  as  principal  in  order  to  facilitate   the
                  transaction; or

         o        negotiated   transactions  between  selling  stockholders  and
                  purchasers without a broker or dealer.

         The selling stockholders and any broker-dealers or other persons acting
on the behalf of parties that  participate in the distribution of the shares may
be deemed to be  underwriters.  Any  commissions  or profits they receive on the
resale of the shares may be deemed to be underwriting  discounts and commissions
under the Securities Act.

         As of the date of this  prospectus,  we are not aware of any agreement,
arrangement or understanding between any broker or dealer and any of the selling
stockholders  with  respect  to the  offer  or sale  of the  shares  under  this
prospectus.

         We have advised the selling  stockholders  that during the time each is
engaged in distributing shares covered by this prospectus, each must comply with
the requirements of the Securities Act and Rule 10b-5 and Regulation M under the
Exchange Act. Under those rules and regulations, they:

         o        may not engage in any  stabilization  activity  in  connection
                  with our securities;
    

                                     - 12 -

<PAGE>

   

         o        must  furnish  each broker  which  offers class A common stock
                  covered by this  prospectus  with the number of copies of this
                  prospectus which are required by each broker; and

         o        may not bid for or purchase any of our  securities  or attempt
                  to induce any person to purchase any of our  securities  other
                  than as permitted under the Exchange Act.

         In the Purchase and  Investment  Agreements  we executed in  connection
with the October 1998 private placement we agreed to indemnify and hold harmless
each selling stockholder against liabilities under the Securities Act, which may
be based upon,  among  other  things,  any untrue  statement  or alleged  untrue
statement of a material  fact or any omission or alleged  omission of a material
fact, unless made or omitted in reliance upon written information provided to us
by that selling stockholder. We have agreed to bear the expenses incident to the
registration of the shares, other than selling discounts and commissions.

                 INDEMNIFICATION FOR SECURITIES ACT LIABILITIES

         Section 145 of the Delaware General Corporation Law allows companies to
indemnify their directors and officers against  expenses,  judgments,  fines and
amounts paid in settlement under the conditions and limitations described in the
law. Our certificate of  incorporation  authorizes us to indemnify our officers,
directors and other agent to the fullest extent permitted under Delaware law.

         Our  certificate  of  incorporation  provides  that a  director  is not
personally  liable for monetary  damages to us or our stockholders for breach of
his or her fiduciary duties as a director.  A director will be held liable for a
breach  of his or her  duty of  loyalty  to us or our  stockholders,  his or her
intentional misconduct or willful violation of law, actions or in actions not in
good faith,  an unlawful  stock purchase or payment of a dividend under Delaware
law,  or  transactions  from which the  director  derives an  improper  personal
benefit.  This  limitation  of  liability  does not affect the  availability  of
equitable  remedies  against  the  director   including   injunctive  relief  or
rescission.

         We have purchased a directors and officers  liability and reimbursement
policy that covers  liabilities  of our  directors  and officers  arising out of
claims  based  upon acts or  omissions  in their  capacities  as  directors  and
officers.

        Insofar as indemnification  for liabilities arising under the Securities
Act may be permitted to our directors, officers and controlling persons pursuant
to the  foregoing  provisions,  or  otherwise,  we have been advised that in the
opinion of the  Securities  and  Exchange  Commission  such  indemnification  is
against  public  policy as expressed in the  Securities  Act and is,  therefore,
unenforceable.
    

                                     - 13 -

<PAGE>

   


                                  LEGAL MATTERS

        The validity of the shares of class A common stock being offered will be
passed upon for ABS by Parker Chapin Flattau & Klimpl, LLP.

                                     EXPERTS

        The audited  consolidated  financial  statements,  including the related
notes to those  statements,  incorporated  by reference in this  prospectus  and
elsewhere in the  registration  statement  have been audited by Arthur  Andersen
LLP,  independent public accountants,  as indicated in their report with respect
to those statements.  Those financial  statements and report are incorporated by
reference  herein in  reliance  upon the  authority  of said firm as  experts in
accounting and auditing in giving said reports.

    
                                     - 14 -

<PAGE>


   
================================================================================



     We have not  authorized any dealer,               10,800,000 Shares        
salesperson  or any other person to give                                        
any information or to represent anything                                        
not  contained in this  prospectus.  You                                        
must  not   rely  on  any   unauthorized      American Biogenetic Sciences, Inc.
information.  This  prospectus  does not                                        
offer to sell or buy any  shares  in any                                        
jurisdiction  where it is unlawful.  The                                        
information   in  this   prospectus   is             Class A Common Stock       
current as of _____________, 1999.                                              
                                                                                
                                                                                
                                              

     ---------------------                        --------------------

       TABLE OF CONTENTS                               PROSPECTUS
     ---------------------                         ---------------------

                                   Page
                                   ----

Prospectus Summary....................2
Risk Factors..........................3
Information Regarding
    Forward-Looking Statements........7
Where You Can Find More
    Information About Us..............7
Use of Proceeds.......................8
Dilution..............................8                  ________ __, 1999
Shares Eligible for Future Sale.......9
Selling Stockholders ................10
Plan of Distribution ................12
Indemnification for Securities
   Act Liabilities...................13
Legal Matters........................14
Experts .............................14

    
================================================================================

<PAGE>

   

                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14.  Other Expenses of Issuance and Distribution

      Listed below is an estimate of the fees and expenses payable in connection
with the proposed offering of the shares which will be paid by ABS.



SEC Registration Fee.....................................$  2,580.17
Accounting Fees and Expenses.............................$  3,500.00
Legal Fees and Expenses..................................$  7,500.00
Miscellaneous............................................$  1,419.83
                                                          ----------

      TOTAL...............................................$15,000.00

Item 15.  Indemnification of Directors and Officers

         Section  145 of the  General  Corporation  Law of the State of Delaware
(the "DGCL") provides,  in general,  that a corporation  incorporated  under the
laws of the State of Delaware,  such as ABS, may indemnify any person who was or
is a party or is  threatened  to be made a party to any  threatened,  pending or
completed  action,  suit or proceeding,  other than a derivative action by or in
the right of the corporation,  by reason of the fact that the person is or was a
director, officer, employee or agent of the corporation, or is or was serving at
the  request of the  corporation  as a director,  officer,  employee or agent of
another  enterprise,  against  expenses,  judgments,  fines and amounts  paid in
settlement  actually and reasonably  incurred by that person in connection  with
that  action,  suit or  proceeding  if that person  acted in good faith and in a
manner  that  person  reasonably  believed  to be in or not  opposed to the best
interests  of the  corporation,  and,  with  respect to any  criminal  action or
proceeding,  had no  reasonable  cause to  believe  that  person's  conduct  was
unlawful.  In the  case of a  derivative  action,  a  Delaware  corporation  may
indemnify that person against expenses actually and reasonably  incurred by that
person in  connection  with the defense or  settlement of that action or suit if
that person acted in good faith and in a manner that person reasonably  believed
to be in or not opposed to the best interests of the corporation, except that no
indemnification  shall be made in respect  of any  claim,  issue or matter as to
which that  person  shall  have been  adjudged  to be liable to the  corporation
unless and only to the extent  that the court  determines  that person is fairly
and reasonably entitled to indemnity for those expenses.

         Article VII of the registrant's By-laws provides for indemnification of
directors, officers, employees and agents of ABS to the fullest extent permitted
under  Delaware  law. In addition,  Article TENTH of the  registrant's  Restated
Certificate  of  Incorporation  provides,  in  general,  that no director of the
registrant  shall  be  personally  liable  to  the  registrant  or  any  of  its
stockholders  for monetary  damages for breach of fiduciary  duty as a director,
except for liability (i) for any breach of the director's duty of loyalty to the
corporation or its stockholders, (ii) for acts or omissions not in good faith or
which involve intentional  misconduct or a knowing violation of law, (iii) under
Section  174 of the DGCL  (which  provides  that  under  certain  circumstances,
directors  may  be  jointly  and  severally  liable  for  willful  or  negligent
violations  of the DGCL  provisions  regarding the payment of dividends or stock
repurchases or redemptions),  as the same exists or hereafter may be amended, or
(iv) for any transaction  from which the director  derived an improper  personal
benefit.

         Under the  Purchase  and  Investment  Agreements  between  ABS and each
selling  stockholder,  ABS has agreed to indemnify and hold harmless the selling
stockholder,  its officers,  directors and partners and each person  controlling
the selling  stockholder  (within the  meaning of the  Securities  Act) and each
underwriter,  if any,  and each person who so controls any  underwriter  against
all,  claims,  losses,  damages and liabilities (or actions in respect  thereof)
arising out of or based upon any untrue
    

                                      II-2

<PAGE>

   

statement (or alleged  untrue  statement)  of a material  fact  contained in the
registration  statement  (including any prospectus or other document incident to
that  registration or related  qualification or compliance with state securities
laws) or based on any omission (or alleged omission) to state therein a material
fact required to be stated therein or necessary to make the  statements  therein
not  misleading  or any  violation  by ABS of the  Securities  Act or any  state
securities law, relating to any action or inaction required by ABS in connection
with that  registration,  qualification  or  compliance,  and to reimburse  each
indemnified  person  for any legal and other  expenses  reasonably  incurred  in
connection  with   investigating  and  defending  any  claim,   loss,   damages,
liabilities or action;  provided that ABS will not be liable in that case to the
extent that any claim, loss, damage,  liabilities or expense arises out of or is
based on any untrue  statement  or omission  (or  alleged  untrue  statement  or
omission)  made in reliance  upon and in  conformity  with  written  information
furnished to ABS by any indemnified  person stated to be specifically for use in
the registration  statement (as to which the selling stockholders have agreed to
indemnify  ABS, its officers and  directors  and each person who controls ABS or
the Underwriter).

         ABS has purchased a Directors and Officers  Liability and Reimbursement
policy that covers  liabilities  of directors and officers of ABS arising out of
claims  based  upon acts or  omissions  in their  capacities  as  directors  and
officers.
    

                                      II-3

<PAGE>

   

Item 16.  Exhibits


Exhibit
Number
- ------

*3.1          Restated  Certificate of  Incorporation  of the Company,  as filed
              with the  Secretary  of State of the State of Delaware on July 30,
              1996  (filed  as  Exhibit  4.01  to  the  Company's   Registration
              Statement on Form S-8, File No. 333-09473).

*3.2          Amended and Restated By-Laws of the Company (filed as Exhibit 4.02
              to the  Company's  Registration  Statement  on Form S-8,  File No.
              333-09473).

*5            Opinion of Parker Chapin Flattau & Klimpl,  LLP to the legality of
              the Class A common stock being offered.  Incorporated by reference
              to Exhibit 5 to the original registration  statement,  file number
              333-69735, filed with the Commission on December 24, 1998.

23.1          Consent of Arthur Andersen LLP.

*23.2         Consent  of Parker  Chapin  Flattau & Klimpl,  LLP  (contained  in
              Exhibit  5).  Incorporated  by  reference  to Exhibit  23.2 to the
              initial  filing  of  the  registration   statement,   file  number
              333-69735, filed with the Commission on December 24, 1998.

24            Power of Attorney  (contained on Signature  Page of this Amendment
              No. 1 to the Registration Statement).

*99           Form of Purchase and Investment  Agreement executed by the Company
              and  each  of  the  selling  stockholders  on  October  27,  1998.
              Incorporated   by   reference   to  Exhibit  99  to  the  original
              registration  statement,  file  number  333-69735,  filed with the
              Commission on December 24, 1998.


- -----------------------

*        Not filed herewith.  In accordance with Rule 411 promulgated  under the
         Securities Act of 1933, as amended,  reference is made to the documents
         previously  filed  with  the  Commission,  which  are  incorporated  by
         reference herein.


Item 17.  Undertakings

        (a)     The undersigned Registrant hereby undertakes:

                (1) To file,  during  any  period  in which  offers or sales are
being made, a post-effective amendment to this Registration Statement:

    

                                      II-4

<PAGE>
   

                     (i)  To include any prospectus required by Section 10(a)(3)
                of the Securities Act;

                     (ii) To  reflect  in the  prospectus  any  facts or  events
                arising after the effective date of the  Registration  Statement
                (or the most recent  post-effective  amendment  thereof)  which,
                individually or in the aggregate, represent a fundamental change
                in the information included in the Registration Statement;

                     (iii) To include any material  information  with respect to
                the  plan  of  distribution  not  previously  disclosed  in  the
                Registration   Statement   or  any   material   change  to  such
                information in this Registration Statement;

                Provided,  however,  that paragraphs (a)(1)(i) and (a)(1)(ii) do
                not  apply  if the  information  required  to be  included  in a
                post-effective  amendment  by those  paragraphs  is contained in
                periodic  reports filed by ABS under Section 13 or Section 15(d)
                of the Securities  Exchange Act of 1934 that are incorporated by
                reference in this Registration Statement.

                (2) That, for the purpose of determining any liability under the
Securities  Act,  each  post-effective  amendment  shall be  deemed  to be a new
registration  statement  relating to the  securities  offered  therein,  and the
offering of such  securities  at the time shall be deemed to be the initial bona
fide offering thereof.

                (3) To remove  from  registration  by means of a  post-effective
amendment  any of the  securities  being  registered  which remain unsold at the
termination of the offering.

         (b)  The  undersigned  Registrant  undertakes  that,  for  purposes  of
determining  any liability  under the Securities Act, each filing of ABS' annual
report under Section 13(a) or Section  15(d) of the  Securities  Exchange Act of
1934 that is  incorporated by reference in the  Registration  Statement shall be
deemed to be a new  registration  statement  relating to the securities  offered
therein,  and the offering of such securities at that time shall be deemed to be
the initial bona fide offering thereof.

         (c)  Insofar  as  indemnification  for  liabilities  arising  under the
Securities Act may be permitted to directors,  officers and controlling  persons
of ABS under its By-Laws, or otherwise, ABS has been advised that in the opinion
of the Securities and Exchange Commission such indemnification is against public
policy as expressed in the Securities Act and is, therefore,  unenforceable.  In
the event that a claim for indemnification  against such liabilities (other than
the  payment  by ABS of  expenses  incurred  or paid by a  director,  officer or
controlling  person of ABS in the  successful  defense  of any  action,  suit or
proceeding)  is  asserted by such  director,  officer or  controlling  person in
connection with the securities being registered, ABS will, unless in the opinion
of its counsel the matter has been settled by controlling precedent, submit to a
court of appropriate  jurisdiction the question whether such  indemnification by
it is against  public  policy as  expressed  in the  Securities  Act and will be
governed by the final adjudication of such issue.
    

                                      II-5

<PAGE>
   

                                   SIGNATURES
                                   ----------

         Pursuant  to the  requirements  of the  Securities  Act  of  1933,  the
registrant certifies that it has reasonable grounds to believe that it meets all
of the  requirements  for filing on Form S-3 and has duly caused this  Amendment
No.  1 to  the  Registration  Statement  to be  signed  on  its  behalf  by  the
undersigned,  thereunto duly authorized,  in the Town of Copiague,  State of New
York, on the 7th day of April, 1999.


                                     AMERICAN BIOGENETIC SCIENCES, INC.


                                     By:  /s/ Alfred J. Roach      
                                     -------------------------------------------
                                          Alfred J. Roach, Chairman of the Board

         KNOW ALL PERSONS BY THESE  PRESENTS,  that each person whose  signature
appears below constitutes and appoints each of Alfred J. Roach, Josef C. Schoell
and  Timothy  J.  Roach  and each of them  with  power of  substitution,  as his
attorney-in-fact,  in all  capacities,  to sign any amendments to this Amendment
No. 1 to the Registration Statement (including post-effective amendments) and to
file  the  same,  with  exhibits  thereto  and  other  documents  in  connection
therewith,  with the Securities and Exchange  Commission,  hereby  ratifying and
confirming all that said  attorney-in-facts or their substitutes may do or cause
to be done by virtue hereof.

         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
Amendment  No. 1 to the  Registration  Statement  has been  signed  below by the
following persons in the capacities indicated on the 7th day of April, 1999.

      Signature                           Title
      ---------                           -----

/s/ Alfred J. Roach
- -----------------------------
Alfred J. Roach                    Chairman of the Board, Director

/s/ John S. North
- -----------------------------
John S. North                      President, Chief Executive Officer, Director

/s/ Josef C. Schoell                
- -----------------------------      Vice President-Finance (Principal Financial
Josef C. Schoell                   and Accounting Officer)

*
- -----------------------------
Gustav Victor Rudolph Born         Director

*
- -----------------------------
Ellena M. Byrne                    Director

/s/ Glenna M. Crooks
- -----------------------------
Glenna M. Crooks                   Director

*
- -----------------------------
Joseph C. Hogan                    Director

*
- -----------------------------
Timothy J. Roach                   Director

*
- -----------------------------
William G. Sharwell                Director

*By:  /s/ Josef C. Schoell       
- -----------------------------
Attorney-in-Fact

    

<PAGE>

   

                                  EXHIBIT INDEX


Exhibit
Number
- ------

*3.1          Restated  Certificate of  Incorporation  of the Company,  as filed
              with the  Secretary  of State of the State of Delaware on July 30,
              1996  (filed  as  Exhibit  4.01  to  the  Company's   Registration
              Statement on Form S-8, File No. 333-09473).

*3.2          Amended and Restated By-Laws of the Company (filed as Exhibit 4.02
              to the  Company's  Registration  Statement  on Form S-8,  File No.
              333-09473).

*5            Opinion of Parker Chapin Flattau & Klimpl,  LLP to the legality of
              the Class A common stock being offered.  Incorporated by reference
              to Exhibit 5 to the initial filing of the registration  statement,
              file number  333-69735,  filed with the Commission on December 24,
              1998.

23.1          Consent of Arthur Andersen LLP.

*23.2         Consent  of Parker  Chapin  Flattau & Klimpl,  LLP  (contained  in
              Exhibit  5).  Incorporated  by  reference  to Exhibit  23.2 to the
              original registration statement, file number 333-69735, filed with
              the Commission on December 24, 1998.

24            Power of Attorney  (contained on Signature  Page of this Amendment
              No. 1 to the Registration Statement).

*99           Form of Purchase and Investment  Agreement executed by the Company
              and  each  of  the  selling  stockholders  on  October  27,  1998.
              Incorporated   by   reference   to  Exhibit  99  to  the  original
              registration  statement,  file  number  333-69735,  filed with the
              Commission on December 24, 1998.


- -----------------------

*        Not filed herewith. In accordance with Rule 411 promulgated pursuant to
         the  Securities  Act of  1933,  as  amended,  reference  is made to the
         documents previously filed with the Commission,  which are incorporated
         by reference herein.
    

<PAGE>
   
                                                                    EXHIBIT 23.1


                    CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS


As independent  public  accountants,  we hereby consent to the  incorporation by
reference  in this  Registration  Statement  of our report dated March 22, 1999,
included in American  Biogenetic  Sciences,  Inc.'s Form 10-K for the year ended
December  31,  1998,  and to  all  references  to  our  firm  included  in  this
Registration Statement.




/s/ Arthur Andersen LLP

Melville, New York
April 9, 1999


    


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