AMERICAN BIOGENETIC SCIENCES INC
PRE 14A, 2000-04-13
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>   1


                            SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Filed by the Registrant [X]

Filed by a party other than the Registrant [ ]

Check the appropriate box:

[X]      Preliminary Proxy Statement
[ ]      Confidential, for Use of the Commission Only (as permitted by Rule
         14a-6(e)(2))
[ ]      Definitive Proxy Statement
[ ]      Definitive Additional Materials
[ ]      Soliciting Material Pursuant to ss.240.14a-11(c) or ss.240.14a-12

                       AMERICAN BIOGENETIC SCIENCES, INC.
                (Name of Registrant as Specified in Its Charter)


    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[X]      No fee required

[ ]      Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11

         1)       Title of each class of securities to which transaction
                  applies:

         2)       Aggregate number of securities to which transaction applies:

         3)       Per unit price or other underlying value of transaction
                  computed pursuant to Exchange Act Rule 0-11 (Set forth the
                  amount on which the filing fee is calculated and state how it
                  was determined):

         4)       Proposed maximum aggregate value of transaction:

         5)       Total fee paid:

[ ]      Fee paid previously with preliminary materials.

[ ]      Check box if any part of the fee is offset as provided by Exchange
         Act Rule 0-11(a)(2) and identify the filing for which the offsetting
         fee was paid previously. Identify the previous filing by registration
         statement number, or the Form or Schedule and the date of its filing.

         1)       Amount Previously Paid:

         2)       Form, Schedule or Registration Statement No.:

         3)       Filing Party:

         4)       Date Filed:


<PAGE>   2


                       AMERICAN BIOGENETIC SCIENCES, INC.

                                1375 AKRON STREET
                            COPIAGUE, NEW YORK 11726

                              --------------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

                              --------------------

                                  June 13, 2000

                              --------------------

         NOTICE IS HEREBY GIVEN that the 2000 Annual Meeting of Stockholders of
American Biogenetic Sciences, Inc., a Delaware corporation (the "Company"), will
be held at The Huntington Hilton, 598 Broadhollow Road, Melville, New York, on
Tuesday, June 13, 2000 at 3:00 p.m., Eastern Daylight Savings Time. The
following matters are to be presented for consideration at the meeting:

              1.  The election of seven directors to serve until the next annual
                  meeting of stockholders and until their respective successors
                  are elected and qualified;

              2.  A proposal to approve the Company's 2000 Stock Option Plan;

              3.  A proposal to approve amendments to the Company's 1993
                  Non-Employee Director Stock Option Plan;

              4.  A proposal to ratify the selection of Arthur Andersen LLP as
                  the Company's independent auditors for the year ending
                  December 31, 2000; and

              5.  The transaction of such other business as may properly come
                  before the meeting or any adjournments or postponements
                  thereof.

         The close of business on April 20, 2000 has been fixed as the record
date for the determination of stockholders entitled to notice of, and to vote
at, the meeting and any adjournments or postponements thereof. A list of such
stockholders will be open for examination by any stockholder for any purpose
germane to the meeting, during ordinary business hours, for a period of at least
ten days prior to the meeting at the offices of the Company located at 1375
Akron Street, Copiague, New York.

                                        By Order of the Board of Directors,

                                        Timothy J. Roach
                                        Secretary
Copiague, New York
May 1, 2000

WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE COMPLETE, DATE AND SIGN
THE ENCLOSED PROXY AND MAIL IT PROMPTLY IN THE ENCLOSED ENVELOPE IN ORDER TO
ASSURE REPRESENTATION OF YOUR SHARES. NO POSTAGE IS NEEDED IF MAILED IN THE
UNITED STATES.


<PAGE>   3


                       AMERICAN BIOGENETIC SCIENCES, INC.

                                1375 AKRON STREET
                            COPIAGUE, NEW YORK 11726

                              --------------------

                                 PROXY STATEMENT

                              --------------------

         This Proxy Statement is furnished to the holders of Class A Common
Stock ("Class A Common Stock") and to the sole holder of Class B Common Stock
("Class B Common Stock") of American Biogenetic Sciences, Inc. (the "Company")
in connection with the solicitation by the Board of Directors of the Company of
proxies in the accompanying form ("Proxy" or "Proxies") to be used at the 2000
Annual Meeting of Stockholders of the Company (the "Meeting") to be held on
Tuesday, June 13, 2000, at 3:00 p.m., Eastern Daylight Savings Time, at The
Huntington Hilton, 598 Broadhollow Road, Melville, New York, and at any
adjournments and postponements thereof, for the purposes set forth in the
accompanying Notice of Annual Meeting. It is anticipated that this Proxy
Statement and the Proxies will be mailed to stockholders on or about May 1,
2000.

         The cost of preparing, assembling and mailing the Notice of Annual
Meeting, this Proxy Statement and Proxies will be borne by the Company. The
Company will also reimburse brokers who are holders of record of Class A Common
Stock for their expenses in forwarding Proxies and Proxy soliciting materials to
the beneficial owners of such shares. In addition to the use of the mails,
Proxies may be solicited without extra compensation by directors, officers and
employees of the Company by telephone, telecopy, telegraph or personal
interview. The Company has retained W.F. Doring & Co., Inc., 150 Bay Street,
Jersey City, New Jersey 07302 to aid in the solicitation of Proxies. For its
services, W.F. Doring & Co., Inc. will receive a fee of $2,500 plus
reimbursement for certain out-of-pocket expenses. Proxies properly executed and
received in time for the Meeting will be voted. A stockholder who signs and
returns a Proxy has the power to revoke it at any time before it is exercised by
giving written notice of revocation to the Company, 1375 Akron Street, Copiague,
New York 11726, Attention: Secretary, by a duly executed proxy of later date, or
by voting in person at the Meeting.

                                VOTING SECURITIES

         The close of business on April 20, 2000 has been fixed as the record
date for the determination of stockholders entitled to notice of, and to vote
at, the Meeting (the "Record Date"). There were outstanding, as of the close of
business on that date, [40,506,612] shares of Class A Common Stock and 3,000,000
shares of Class B Common Stock. A majority of the total of such outstanding
shares of Class A Common Stock and Class B Common Stock, represented in person
or by Proxy at the Meeting, is required to constitute a quorum for the
transaction of business at the Meeting. Holders of Class A Common Stock have one
vote for each share thereof held of record and the holder of Class B Common
Stock has ten votes for each share thereof held of record. The Class A Common
Stock and Class B Common Stock will vote as one class on all matters proposed
herein to be submitted to stockholders at the Meeting. Proxies submitted which
contain abstentions or broker nonvotes will be deemed present at the Meeting in
determining the presence of a quorum. Abstentions and broker nonvotes will have
no effect on the outcome of the election of directors. Abstentions will, in
effect, be deemed negative votes on each proposal, but broker nonvotes will not
affect the results of any of the matters proposed herein to be submitted to
stockholders at the Meeting.

         Unless otherwise specified, all Proxies received will be voted for the
election of all nominees named herein to serve as directors, in favor of
approval of the Company's 2000 Stock Option Plan and the proposed amendments to
the Company's 1993 Non-Employee Director Stock Option Plan, and to ratify the
selection of Arthur Andersen LLP as the Company's independent auditors. The
Board of Directors does not intend to bring before the Meeting any matter other
than those specifically described above and knows of no matters other than the
foregoing to come before the Meeting. If any other matters or motions come
before the Meeting, it is


<PAGE>   4

the intention of the persons named in the accompanying Proxy to vote such Proxy
in accordance with their judgment on such matters or motions, including any
matters dealing with the conduct of the Meeting.

                          SECURITY HOLDINGS OF CERTAIN
                      STOCKHOLDERS, MANAGEMENT AND NOMINEES

         The following table sets forth information as at the Record Date with
respect to the beneficial ownership of the Company's Class A Common Stock and
Class B Common Stock by (i) each person known by the Company to beneficially own
more than 5% of the outstanding shares of Class A Common Stock or Class B Common
Stock, (ii) each director of the Company, (iii) each executive officer named in
the Summary Compensation Table under the caption "Executive Compensation" and
(iv) all executive officers and directors of the Company as a group. Each share
of Class A Common Stock is entitled to one vote per share while each share of
Class B Common Stock is entitled to ten votes per share. The Company understands
that, except as noted below, each beneficial owner has sole voting and
investment power with respect to all shares attributable to such owner.

<TABLE>
<CAPTION>
                                                     Class A Common Stock (1)              Class B Common Stock
                                                     ------------------------              --------------------

                                                                No.          Percent              No.         Percent
Beneficial Owner                                         of  Shares         of Class        of Shares        of Class
- ----------------                                         ----------         --------        ---------        --------

<S>                                                  <C>                       <C>          <C>                  <C>
Alfred J. Roach(2)                                   11,007,250 (2)            23.4%        3,000,000            100%

John S. North                                           309,000 (3)                *               --              --

Timothy J. Roach                                        830,000 (3)             2.0%               --              --

Ellena Byrne                                            197,500 (3)(4)             *               --              --

Joseph C. Hogan                                          45,000 (3)                *               --              --

Gustav V. R. Born                                        52,500 (3)                *               --              --

Glenna M. Crooks                                         15,000 (3)                *               --              --

Josef C. Schoell                                        306,500 (3)(5)             *               --              --

All executive officers and
directors as a group (10 persons,
including the foregoing)                             13,055,250 (6)            26.7%        3,000,000            100%
</TABLE>

- ----------------------
(1)      Asterisk indicates less than one percent. Shares of Class A Common
         Stock subject to issuance upon conversion of Class B Common Stock or
         Series A Preferred Stock into Class A Common Stock and upon exercise of
         options and warrants that were exercisable on, or become exercisable
         within 60 days after, the Record Date are considered owned by the
         holder thereof and outstanding for purposes of computing the percentage
         of outstanding Class A Common Stock that would be owned by such person,
         but (except for the computation of beneficial ownership by all
         executive officers and directors as a group) are not considered
         outstanding for purposes of computing the percentage of outstanding
         Class A Commons Stock owned by any other person.

(2)      The address of Mr. Roach is Route 2 - Kennedy Avenue, Guaynabo, Puerto
         Rico 00657. Beneficial ownership of Class A Common Stock includes
         3,000,000 shares of Class A Common Stock issuable upon conversion of
         the


                                      -2-
<PAGE>   5


         same number of shares of Class B Common Stock on a share for share
         basis, 1,000,000 shares of Class A Common Stock issuable upon
         conversion of 1,000 shares of Series A Preferred Stock and 1,000,000
         shares of Class A Common Stock subject to outstanding warrants and
         1,535,000 shares of Class A Common Stock subject to outstanding
         options.

(3)      Includes shares of Class A Common Stock subject to options as follows:
         for Timothy J. Roach, 820,000; for John S. North, 175,000; for Ellena
         Byrne, 170,000; for Joseph C. Hogan, 25,000; for Gustav V.R. Born,
         50,000; for Glenna M. Crooks, 15,000; and for Josef C. Schoell,
         277,500.

(4)      Includes 7,500 shares owned, and 20,000 shares subject to options held,
         by her husband. The inclusion of these amounts should not be construed
         as an admission that Ms. Byrne is the beneficial owner of these shares.

(5)      Includes 200 shares owned by his wife. The inclusion of these amounts
         should not be construed as an admission that Mr. Schoell is the
         beneficial owner of these shares.

(6)      Includes 3,000,000 shares of Class A Common Stock issuable upon
         conversion of the same number of shares of Class B Common Stock,
         1,000,000 shares of Class A Common Stock issuable upon conversion of
         1,000 shares of Series A Preferred Stock 1,000,000 shares of Class A
         Common Stock subject to outstanding warrants and 3,328,500 shares of
         Class A Common Stock subject to outstanding options.


                                   PROPOSAL 1.

                              ELECTION OF DIRECTORS

         The Company's By-Laws provide that the number of members of the Board
of Directors shall be not less than three or more than nine, the exact number to
be fixed by resolution of the Board of Directors. The Board of Directors
presently consists of seven members. Each of the nominees, other than John S.
North and Glenna M. Crooks. Ph.D. (who were elected as directors by the Board in
November 1998 and March 1999, respectively), has been previously elected by
stockholders of the Company.

         Unless authority to do so is withheld, Proxies will be voted at the
Meeting for the election of each of the nominees named below to serve as
directors of the Company until the next annual meeting of stockholders and until
their respective successors are elected and qualified. In the event that any of
the nominees should become unavailable or unable to serve for any reason, the
holders of Proxies have discretionary authority to vote for one or more
alternate nominees designated by the Board of Directors. The Company believes
that all of the nominees are available to serve as directors.

BACKGROUND OF NOMINEES

         ALFRED J. ROACH, 84, has been Chairman of the Board of Directors of the
Company since its organization in September 1983 and, from September 1983 until
November 1998, also served as the Company's Chief Executive Officer. Mr. Roach
has served as Chairman of the Board and/or President of TII Industries, Inc.
("TII"), a corporation engaged in manufacturing and marketing telecommunications
products, and its predecessor since its founding in 1964. Mr. Roach devotes a
majority of his time to the business of the Company.

         JOHN S. NORTH, 55, has been President, Chief Executive Officer and
member of the Board of Directors of the Company since joining the Company in
November 1998. From April 1969 until he joined the Company, Mr. North was
employed by Eli Lilly and Company ("Lilly"), which develops, manufactures and
sells pharmaceutical products, in a number of management positions, including
Director of Marketing for Lilly's Dista Products Division in the United Kingdom
(from March 1982 until January 1984), Director of New Product Planning for
Europe and the Nordic Area (from January 1984 until October 1986), in which
geographic areas he was responsible for the launch of Lilly's antidepressant
Prozac, Manager of International Relations (from October 1986 until April 1993)
and Director of International Public and Government Affairs for Lilly's
pharmaceutical division (from April 1993 until joining ABS).


                                      -3-
<PAGE>   6

         ELLENA M. BYRNE, 49, has been Executive Vice President and a director
of the Company since March 1995. From January 1986 until December 1991, Ms.
Byrne served as Vice President-Administration of the Company and, from December
1991 until March 1995, Ms. Byrne served in various capacities with the Company,
including Director of Operations for Europe and Asia.

         TIMOTHY J. ROACH, 53, has been Treasurer, Secretary and a director of
the Company since September 1983. He has also been affiliated with TII since
1974, serving as its President since July 1980, Chief Operating Officer since
May 1987, Vice Chairman of the Board since October 1993, Chief Executive Officer
since January 1995 and a director since January 1978. Mr. Roach devotes such
time as is necessary to the business of the Company to discharge his duties as
Treasurer, Secretary and a director. Timothy J. Roach is the son of Alfred J.
Roach.

         GUSTAV VICTOR RUDOLF BORN, M.D., D.Phil., F.R.S., 78, has been a
director of the Company since January 1997. Since 1988, Dr. Born has been
Research Director of The William Harvey Research Institute at St. Bartholomew's
Hospital Medical College, London, England and Emeritus Professor of Pharmacology
in the University of London. Among Dr. Born's distinctions, appointments and
activities are: Fellowship and Royal Medal of the Royal Society; and Foundation
President of the British Society for Thrombosis and Haemostasis.

         GLENNA M. CROOKS, Ph.D., 50, has been a director of the Company since
March 1999. Dr. Crooks has been President of Strategic Health Policy
International, Inc., a health care consulting and planning firm that advises
governments, businesses and industry trade associations in the U.S. and overseas
on the development and application of business strategy, a company she formed in
October 1994. From January 1991 until September 1994, Dr. Crooks served as Vice
President-Worldwide Sales and Operations for the Vaccines Division of Merck &
Co., Inc., a pharmaceutical company that develops, manufactures and markets
human and animal health products.

         JOSEPH C. HOGAN, Ph.D., 77, has been a director of the Company since
December 1983. Dr. Hogan served as Dean of the College of Engineering of the
University of Notre Dame from 1967 until 1981, following which he performed
various services for the University of Notre Dame until 1985, where he remains
Dean Emeritus. From 1985 until his retirement in 1987, Dr. Hogan was Director of
Engineering Research and Resource Development at Georgia Institute of Technology
("Georgia Tech"). Dr. Hogan is a director of TII.


                                      -4-
<PAGE>   7


MEETINGS OF THE BOARD OF DIRECTORS

         During the year ended December 31, 1999, the Board of Directors held
six meetings and acted by unanimous written consent on twenty-one occasions
following informal discussions. Each director was present at all of the meetings
of the Board of Directors and committees of the Board on which such director
served that were held during the 1999 fiscal year, except that Dr. Born was not
present at two, Dr.Sharwell was not present at one and Dr. Crooks was not
present at one of the six Board meetings held during 1999.

COMMITTEES OF THE BOARD OF DIRECTORS

         The Board of Directors has an Audit and Compensation Committee, but
does not have a nominating committee.

         The Audit Committee, which presently consists of Mr. Hogan and Ms.
Crooks, is authorized to examine and consider matters related to the audit of
the Company's accounts, the financial affairs and accounts of the Company, the
scope of the independent auditors' engagement and their compensation, the effect
on the Company's financial statements of any proposed changes in generally
accepted accounting principles, disagreements, if any, between the Company's
independent auditors and management, and matters of concern to the independent
auditors resulting from the audit, including the results of the independent
auditors' review of internal accounting controls. This committee is also
authorized to nominate independent auditors, subject to approval by the Board of
Directors. The Audit Committee held one meeting during 1999.

         The Compensation Committee is authorized to consider and recommend to
the Board of Directors the salaries, bonuses and other compensation arrangements
with respect to the executive officers of the Company. This Committee is also
empowered to grant all options under, and administer, the Company's stock option
plans. The Compensation Committee is further empowered to examine, administer
and make recommendations to the full Board with respect to other employee
benefit plans and arrangements of the Company. The Compensation Committee
presently consists of Mr. Hogan and Ms. Crooks. The Compensation Committee
acted by unanimous written consent on twelve occasions during 1999 following
informal discussions.

REMUNERATION OF DIRECTORS

         Each non-employee director receives a fee of $1,000 for each meeting of
the Board of Directors attended by that director in person and not
telephonically. Each director serving on the Audit Committee receives a fee of
$600 for each meeting of the committee attended by that director in person and
not telephonically. All directors are reimbursed for travel expenses incurred in
attending Board and committee meetings. Dr. Born serves as a consultant to the
Company for which he receives compensation at the rate of $12,000 per annum.

         The Company's 1993 Non-Employee Director Stock Option Plan, approved by
stockholders at the Company's 1993 Annual Meeting of Stockholders, provides for
the automatic grant of an option to purchase 10,000 shares of the Company's
Class A Common Stock to each non-employee director holding office immediately
after each annual meeting of stockholders. The exercise price for each option is
equal to the fair market value of the Company's Class A Common Stock on the date
of grant. All options have a term of five years and are exercisable, on a
cumulative basis, at the rate of one quarter of the number of shares subject to
the option in each year commencing one year after the date of the grant. The
amendments to the Company's 1993 Non-Employee Director Stock Option Plan to be
voted on at the 2000 Annual Meeting of Stockholders would increase the term of
these options to ten years and would make these options immediately exercisable.

REQUIRED VOTE


                                      -5-
<PAGE>   8

         A plurality of the votes cast at the Meeting by the holders of Class A
Common Stock and Class B Common Stock voting together as one class, with Class A
Common Stock having one vote per share and Class B Common Stock having ten votes
per share, will be required for the election of directors. The Board of
Directors recommends that stockholders vote FOR each of Alfred J. Roach, John S.
North, Ellena M. Byrne, Timothy J. Roach, Gustav V.R. Born, Glenna M. Crooks
and Joseph C. Hogan to serve as directors of the Company.

                               EXECUTIVE OFFICERS

         The executive officers of the Company, in addition to Alfred J. Roach,
John S. North, Timothy J. Roach and Ellena M. Byrne (whose backgrounds are
described under the caption "Election of Directors - Background of Nominees"
above), are:

         GEORGE CHRISTOFFERSEN, Ph.D., 64, joined the Company in November 1997
as its Director of Research and Development and was elected Vice
President-Research and Development in June 1998. From June 1997 until November
1997, Dr. Christoffersen served as a biotechnology consultant. From September
1991 to May 1997, Dr. Christoffersen was employed by Genzyme Corporation, a
biotechnology company, as Senior Director - Scientific Affairs, where he was
responsible for the identification, evaluation and licensing of new
technologies, as well as managing offsite research projects and establishing
university networks.

         JAMES H. MCLINDEN, Ph.D., 49, has been Vice President - Molecular
Biology of the Company since November 1991. Prior thereto (and since joining the
Company in January 1987), Dr. McLinden served as Director of Molecular Biology
of the Company.

         JOSEF C. SCHOELL, 50, joined the Company in July 1992 as its Controller
and was elected Vice President-Finance and Chief Financial Officer of the
Company in July 1995. Mr. Schoell is a Certified Public Accountant in the State
of New York.


                                      -6-
<PAGE>   9


                             EXECUTIVE COMPENSATION

SUMMARY COMPENSATION TABLE

         The following table sets forth information concerning the annual and
long-term compensation for services in all capacities to the Company during
1997, 1998 and 1999 of each person who served as the Company's chief executive
officer during 1999 and each other person who served as an executive officer of
the Company during 1999 and whose annual compensation for 1999 exceeded
$100,000:



<TABLE>
<CAPTION>
                                                       ANNUAL COMPENSATION               LONG-TERM
                                                                                         COMPENSATION


                                                                              OTHER
NAME AND                                                                      ANNUAL                       ALL OTHER
PRINCIPAL POSITION                   YEAR       SALARY ($)     BONUS ($)   COMPENSATION     OPTIONS      COMPENSATION
- ------------------                   ----       ----------     ---------   ------------     -------      ------------

<S>                                  <C>        <C>            <C>                  <C>     <C>          <C>
Alfred J. Roach,                     1999       $250,000 (3)       --                --     300,000            --
   Chairman of the Board (1)         1998       $250,000           --                --     100,000            --
                                     1997       $250,000           --                --          --            --

John S. North, President and         1999       $260,000 (4)   25,000 (2)            --     250,000      $100,000 (2)
  Chief Executive Officer (2)        1998       $ 25,000                                    300,000


Josef C. Schoell, Vice               1999       $120,000 (5)       --                --     200,000            --
  President Finance and              1998       $120,000           --                --          --            --
  Chief Financial Officer            1997       $103,000           --                --      25,000            --
</TABLE>

- --------------------
(1)      Mr. Roach served as the Company's Chief Executive Officer until
         November 16, 1998.

(2)      Mr. North joined the Company as President and Chief Executive Officer
         on November 16, 1998. Under the terms of his employment agreement, he
         received a one-time $25,000 bonus in January 1999 and a $100,000
         interest free loan during 1999. Loans under this arrangement are to be
         forgiven as to 25% every six months provided Mr. North is still an
         employee of the Company. During 1999, $50,000 of the $100,000 loan
         amount was forgiven.

(3)      Includes $115,000 which was deferred during 1999 at the election of
         Mr. Roach.

(4)      Includes $110,000 which was deferred during 1999 at the election of Mr.
         North.

(5)      Includes $10,000 which was deferred during 1999 at the election of Mr.
         Schoell
 .


                                      -7-
<PAGE>   10


OPTION GRANTS IN LAST FISCAL YEAR

         The following table contains information concerning options to purchase
shares of the Company's capital stock granted by the Company during the year
ended December 31, 1999 to the executive officers named in the Summary
Compensation Table. No stock appreciation rights have been granted by the
Company.

<TABLE>
<CAPTION>
                                          INDIVIDUAL OPTIONS

                                                                                           POTENTIAL REALIZABLE VALUE AT
                                                                                           ASSUMED ANNUAL RATES OF STOCK
                                                                                           PRICE APPRECIATION FOR OPTION
                                                                                           TERM (2)
                     NUMBER OF        PERCENT OF
                     SHARES           TOTAL OPTIONS
                     UNDERLYING       GRANTED TO       EXERCISE
                     OPTIONS          EMPLOYEES IN     PRICE PER       EXPIRATION
NAME                 GRANTED          FISCAL YEAR      SHARE (1)       DATE                     5%              10%
- ----                 ----------       -------------    ---------       ----------               --              ---

<S>                  <C>                  <C>           <C>             <C>                  <C>             <C>
Alfred J. Roach      200,000 (3)          11.0%         $ 1.10           5/25/2004           $65,782         $134,312
                     100,000 (4)           5.5%         $ 0.308         10/20/2004           $ 8,509         $ 18,804

John S. North        150,000 (3)           8.2%         $ 1.00           5/25/2009           $94,334         $239,061
                     100,000 (4)           5.5%         $ 0.28          10/20/2009           $17,609         $ 44,625

Josef C. Schoell     100,000 (3)           5.5%         $ 1.00           5/25/2009           $62,889         $159,374
                     100,000 (4)           5.5%         $ 0.28          10/20/2009           $17,609         $ 44,625
</TABLE>

- -------------
(1)      The exercise price of the options granted to Messrs. Roach, North and
         Schoell was 110%, 100% and 100%, respectively, of the market value of
         the Class A Common Stock on the date of grant.

(2)      These are hypothetical values using assumed compound growth rates
         prescribed by the Securities and Exchange Commission and are not
         intended to forecast possible future appreciation, if any, in the
         market price of the Company's Class A Common Stock.

(3)      Exercisable as to 50% of the number of shares of Class A Common Stock
         underlying the option during each six months commencing six months
         after the date of grant, on a cumulative basis.

(4)      100% exercisable.


                                      -8-
<PAGE>   11



OPTION EXERCISES IN LAST FISCAL YEAR AND YEAR-END VALUES

         No options to purchase shares of the Company's capital stock were
exercised during 1999 by the executive officers named in the Summary
Compensation Table. The following table contains information concerning the
number of shares of Class A Common Stock underlying unexercised options held at
December 31, 1999 by the executive officers named in the Summary Compensation
Table.

<TABLE>
<CAPTION>
                                        NUMBER OF SHARES UNDERLYING
                                        UNEXERCISED OPTIONS HELD AT            VALUE OF UNEXERCISED IN-THE-MONEY
                                        YEAR-END (EXERCISABLE/                 FISCAL OPTIONS HELD AT FISCAL YEAR-END
      NAME                              UNEXERCISABLE)                         (EXERCISABLE/UNEXERCISABLE) (1)
      ----                              ---------------------------            --------------------------------------
<S>                                        <C>                                            <C>
Alfred J. Roach                            1,560,000 / 1,310,000                          $11,250 / $30,450
John S. North                                550,000 /   150,000                          $18,750 / $78,250
Josef C. Schoell                             330,000 /   177,500                          $   -0- / $22,000
</TABLE>

(1)      Represents the closing price of the Company's Class A Common Stock on
         The Nasdaq SmallCap Market on December 31, 1999 ($0.50) less the
         exercise price of each option.

EMPLOYMENT AGREEMENTS

         The Company is a party to an employment agreement with John S. North,
dated as of November 2, 1998, under which Mr. North is serving as President and
Chief Executive Officer of the Company. The agreement provides for a term
expiring November 15, 2001. The Company has the right to terminate the agreement
without cause on thirty days' notice. In the event of termination of the
agreement by the Company without cause, Mr. North is to remain as a consultant
to the Company at his then existing compensation for a period of one year,
provided that the consulting and compensation arrangement is to terminate if Mr.
North enters into full-time employment with a third party. Under the agreement,
Mr. North's current annual salary is $260,000 per annum, he received a one-time
$25,000 bonus in January 1999 and a $100,000 interest free loan during 1999.
Loans under this arrangement are to be forgiven as to 25% every six months
provided Mr. North is still an employee of the Company. During 1999, $50,000 of
the $100,000 loan amount was forgiven. Mr. North was also granted stock options
to purchase an aggregate of 300,000 shares of Class A Common Stock exercisable
at $.25 per share, the market value of the Company's Class A Common Stock on the
date of grant. The options vest as to 25% of the number of shares subject to the
options annually, on a cumulative basis, commencing one year after the date of
grant. The options are for a term of ten years, subject to earlier termination
in certain events.

         As part of his employment agreement, Mr. North has agreed not to
disclose confidential information about the Company during or after employment
and not to compete with the Company during their term of employment and, in
certain instances, following employment.

REPORT OF COMPENSATION COMMITTEE CONCERNING EXECUTIVE COMPENSATION

         The Compensation Committee of the Board of Directors, consisting of.
Joseph C. Hogan and Glenna M. Crooks, "non-employee" directors, within the
meaning of Rule 16b-3 promulgated by the Securities and Exchange Commission
under the Securities Exchange Act of 1934, and "outside directors", within the
meaning of Section 162(m) of the Internal Revenue Code of 1986, as amended
("Section 162(m)"), is authorized to consider and recommend to the Board of
Directors salaries, bonuses and other compensation arrangements for executive
officers and to grant all options under, and administer, the Company's employee
stock option plans.


                                      -9-
<PAGE>   12

         The Compensation Committee believes that the Company, as a development
stage company, should create compensation packages to attract and retain
executives who can bring the experience and skills to the Company necessary for
the development of the Company and development and marketing of its products. To
date, this has been accomplished by utilizing salary as the base compensation
and stock options to promote long-term incentives and conserve the Company's
available cash and, in certain cases, a bonus as an inducement to an executive
to join the Company. As the Company grows, other forms of annual and long-term
compensation arrangements may be developed to provide appropriate incentives and
to reward specific accomplishments.

         In determining base salaries, the Compensation Committee examines,
among other factors, the executive's performance, degree of responsibility and
experience, as well as general employment conditions, competition and economic
factors. No specific weights are assigned to any of the factors employed by the
Compensation Committee. In 1999, the salaries of certain executive officers were
increased, using subjective standards, to recognize their performance.

         The Compensation Committee also makes use of stock options to provide
long-term incentive compensation to many of the Company's employees, including
executive officers, enabling them to benefit, along with all stockholders, if
the market price for Class A Common Stock rises. The Compensation Committee
believes that the use of stock options ties employee interests to those of the
Company's stockholders through stock ownership and potential stock ownership,
while also providing the Company with a means of compensating employees using a
method which enables the Company to conserve its available cash for operations,
including research and development and product development. To assure the
long-term nature of the incentive, options granted have generally not become
exercisable during the first six months to one year after grant and thereafter
have become exercisable over a period of two to four years. Decisions of the
Compensation Committee as to option grants are based, in large measure, upon a
review of such factors as the executive's level of responsibility, other
compensation, accomplishments and goals, and when the last option was granted to
such executive, as well as recommendations and evaluations of the executive's
performance and prospective contributions by the Company's Chairman of the Board
and Chief Executive Officer. Determinations have been made subjectively without
giving weight to specific factors.

         Chief Executive Officer Compensation. Mr. John S. North joined the
Company as President and Chief Executive Officer in November 1998. His base
salary of $260,000, bonus, stock option grant and other benefits (see " --
Employment Agreements," above) were negotiated in connection with Mr. North's
agreement to join the Company. Prior thereto, Alfred J. Roach, the Company's
Chairman of the Board of Directors, served as the Company's Chief Executive
Officer. The salary of Mr. Roach has remained unchanged for the past seven
years. In lieu of any additional cash compensation, the Compensation Committee
determined to grant Mr. Roach options to purchase 300,000 shares of the
Company's Class A Common Stock under the Company's 1996 Stock Option Plan.


                                      -10-
<PAGE>   13

         Certain Tax Legislation. Section 162(m) precludes a public company from
taking a federal income tax deduction for annual compensation in excess of
$1,000,000 paid to its chief executive officer or any of its four other most
highly compensated executive officers. Certain "performance based compensation"
is excluded from the deduction limitation. Any compensation resulting from the
exercise of stock options granted by the Company should be eligible for
exclusion since all options were either granted prior to the adoption of Section
162(m) or under a plan approved by the Company's stockholders which was designed
to conform to regulations for determining whether options are deemed
"performance based compensation." The Committee believes that the limitations on
compensation deductibility under Section 162(m) will have no effect on the
Company in the foreseeable future, and intends to take such action as may be
necessary, including obtaining stockholder approval where required, in order for
compensation not to be subject to the limitation on deductibility imposed by
Section 162(m) of the Code.


                                            Respectfully submitted,

                                            Joseph C. Hogan
                                            Glenna M. Crooks


                                      -11-
<PAGE>   14


PERFORMANCE GRAPH

         The following graph compares the cumulative return to stockholders of
Class A Common Stock from December 31, 1994 (the first point shown in the
following graph) through December 31, 1999 with the Nasdaq Market Index and the
Dow Jones Industry Group BTC - Biotechnology Index for the same period. The
comparison assumes $100 was invested on December 31, 1994 in Class A Common
Stock and in each of the comparison groups, and assumes reinvestment of
dividends (the Company paid no dividends during the periods):


[GRAPH OMITTED]

<TABLE>
<CAPTION>
- ---------------------------------------------------------------------------------------------------------------------
At December 31,                                   1994          1995        1996       1997       1998        1999
- ---------------------------------------------------------------------------------------------------------------------
<S>                                                <C>        <C>         <C>        <C>        <C>         <C>
American Biogenetic Sciences, Inc.                 100        183.33      270.83     127.09      50.00       33.33
Peer Group Index                                   100        185.57      213.24     226.48     297.90      502.56
NASDAQ Market Index                                100        129.71      161.18     197.16     276.08      490.46
- ---------------------------------------------------------------------------------------------------------------------
</TABLE>

SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

         Section 16(a) of the Securities Exchange Act requires the Company's
executive officers and directors, and persons who beneficially own more than 10%
of the Company's Class A Common Stock, to file initial reports of ownership, and
reports of changes of ownership, of the Company's equity securities with the
Securities and Exchange Commission and furnish copies of those reports to the
Company. Based solely on a review of copies of the reports furnished to the
Company, or written representation that no reports were required, the Company
believes that all reports required to be filed by such persons with respect to
the Company's year ended December 31, 1999 were timely filed.

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

         Between September 3, 1999 and January 19, 2000, Mr. Roach loaned the
Company an aggregate of $776,000 at an interest rate of 6% per annum. On March
3, 2000, $500,000 of the principal amount of the Company's indebtedness to Mr.
Roach was exchanged for 1,000 shares of the Company's Series A Preferred Stock
which are convertible into 1,000,000 shares of the Class A Common Stock and
1,000,000 warrants to purchase the Class A Common Stock at a price of $1.00 per
share. The Company made principal payments on


                                      -12-
<PAGE>   15

Mr. Roach's loans in February and March 2000 and repaid the remaining principal
amount of and accrued interest on these loans in April 2000.

         On March 8, 1999, Mr. Roach purchased directly from the Company 440,000
shares of the Company's Class A Common Stock for $495,000 ($1.1250 per share).

                                 PROPOSAL NO. 2

                APPROVAL OF THE COMPANY'S 2000 STOCK OPTION PLAN

         On April 4, 2000, the Board of Directors adopted, subject to
stockholder approval at the Meeting, the Company's 2000 Stock Option Plan (the
"2000 Plan"). The Plan is to replace the Company's 1996 Stock Option Plan (the
"1996 Plan"), the Company's only other plan that permits the grant of options to
employees or consultants. The 2000 Plan, like the 1996 Plan, is designed to
provide an incentive to employees of, and consultants to, the Company and its
present and future subsidiaries and to offer an additional inducement in
obtaining the services of such persons.

         The following summary of certain material features of the 2000 Plan
does not purport to be complete and is qualified in its entirety by reference to
the text of the 2000 Plan, a copy of which is set forth as Exhibit A to this
Proxy Statement.

SHARES SUBJECT TO THE OPTION PLAN AND ELIGIBILITY

         The 2000 Plan authorizes the grant of options to purchase a maximum of
300,000 shares of the Company's Class A Common Stock (subject to adjustment as
described below) to employees (including officers and directors who are
employees) of, and to consultants to, the Company or any of its subsidiaries.
Upon expiration, cancellation or termination of unexercised options, the shares
of the Company's Class A Common Stock subject to such options will again be
available for the grant of options under the 2000 Plan. No options have been
granted to date under the 2000 Plan.

TYPE OF OPTIONS

         Options granted under the 2000 Plan may either be incentive stock
options ("ISOs"), within the meaning of Section 422 of the Internal Revenue Code
of 1986, as amended (the "Code") the Code, or nonqualified stock options which
do not qualify as ISOs ("NQSOs"). ISOs, however, may only be granted to
employees.

ADMINISTRATION

         The 2000 Plan will be administered by a committee of the Company's
Board of Directors (the "Committee") consisting of at least two members of the
Board, each of whom is a "disinterested person" within the meaning of Rule 16b-3
promulgated under the Securities Exchange Act of 1934, as amended (the "Exchange
Act"). It is also intended that each member of the Committee will be an "outside
director", within the meaning of Section 162(m) of the Code. The 2000 Plan will
initially be administered by the Compensation Committee of the Board.

         Among other things, the Committee is empowered to determine, within any
express limits contained in the 2000 Plan, the employees and consultants to be
granted options, whether an option granted to an employee is to be an ISO or an
NQSO, the number of shares of Class A Common Stock to be subject to each option,
the exercise price of each option, the term of each option, the date each option
shall become exercisable as well as any terms, conditions or installments
relating to the exercisability of each option, whether to accelerate the date of
exercise of any option or installment and the form of payment of the exercise
price, to construe each stock option contract ("Contract") between the Company
and an optionee and, with the consent of the optionee, to cancel or modify an
option. The Committee is also authorized to prescribe, amend and


                                      -13-
<PAGE>   16

rescind rules and regulations relating to the 2000 Plan and make all other
determinations necessary or advisable for administering the 2000 Plan.

TERMS AND CONDITIONS OF OPTIONS

         Options granted under the 2000 Plan will be subject to, among other
things, the following terms and conditions:

         (a)      The exercise price of each option will be determined by the
                  Committee; provided, however, that the exercise price of an
                  ISO may not be less than the fair market value of the
                  Company's Class A Common Stock on the date of grant (110% of
                  such fair market value if the optionee owns (or is deemed to
                  own) more than 10% of the voting power of the Company).

         (b)      Options may be granted for terms determined by the Committee;
                  provided, however, that the term of an ISO may not exceed ten
                  years (five years if the optionee owns (or is deemed to own)
                  more than 10% of the voting power of the Company).

         (c)      The maximum number of shares of the Company's Common Stock for
                  which options may be granted to an employee in any. calendar
                  year is 500,000. In addition, the aggregate fair market value
                  of shares with respect to which ISOs may be granted to an
                  employee which are exercisable for the first time during any
                  calendar year may not exceed $100,000.

         (d)      The exercise price of each option is payable in full upon
                  exercise or, if the applicable Contract permits, in
                  installments. Payment of the exercise price of an option may
                  be made in cash, or, if the applicable Contract permits, in
                  shares of the Company's Class A Common Stock or any
                  combination thereof.

         (e)      Options may not be transferred other than by will or by the
                  laws of descent and distribution, and may be exercised during
                  the optionee's lifetime only by the optionee.

         (f)      Except as may otherwise be provided in the applicable
                  Contract, if the optionee's relationship with the Company as
                  an employee or consultant is terminated for any reason other
                  than death or disability, the option may be exercised, to the
                  extent exercisable at the time of termination of such
                  relationship, within three months thereafter, but in no event
                  after the expiration of the term of the option; provided,
                  however, that if the relationship is terminated either for
                  cause or without the consent of the Company, the option will
                  terminate immediately. Options are not affected by a change in
                  the status of an optionee so long as the optionee continues to
                  be an employee of, or a consultant to, the Company. In the
                  case of the death of an optionee while an employee or
                  consultant (or, generally, within three months after
                  termination of such relationship, or within one year after
                  termination of employment by reason of disability), except as
                  otherwise provided in the Contract, the optionee's legal
                  representative or beneficiary may exercise the option, to the
                  extent exercisable on the date of death, within one year after
                  such date, but in no event after the expiration of the term of
                  the option. An optionee whose relationship with the Company is
                  terminated by reason of disability may exercise the option, to
                  the extent exercisable at the time of such termination, within
                  one year thereafter, but not after the expiration of the term
                  of the option.

         (g)      The Company may withhold cash and/or shares of the Company's
                  Class A Common Stock having an aggregate value equal to the
                  amount which the Company determines is necessary to meet its
                  obligations to withhold any federal, state and/or local taxes
                  or other amounts incurred by reasons of the grant or exercise
                  of an option or the disposition of shares acquired upon the
                  exercise of the option. Alternatively, the Company may require
                  the optionee to pay the Company such amount, in cash, promptly
                  upon demand.


                                      -14-
<PAGE>   17

ADJUSTMENT IN EVENT OF CAPITAL CHANGES

         Appropriate adjustments will be made in the number and kind of shares
available under the 2000 Plan, in the number and kind of shares subject to each
outstanding option and the exercise prices of such options, as well as the
limitation on the number of shares that may be granted to any employee in any
calendar year, in the event of any change in the Company's Class A Common Stock
by reason of any stock dividend, split-up, combination, reclassification,
recapitalization, merger in which the Company is not the surviving corporation,
exchange of shares or the like. In the event of (a) the liquidation or
dissolution of the Company, or (b) a merger in which the Company is not the
surviving corporation or a consolidation, any outstanding options shall
terminate upon the earliest of any such event, unless other provision is made
therefor in the transaction.

DURATION AND AMENDMENT OF THE 2000 PLAN

         No option may be granted under the 2000 Plan after March 30, 2010. The
Board of Directors may at any time terminate or amend the 2000 Plan; provided,
however, that, without the approval of the Company's stockholders, no amendment
may be made which would (a) except as a result of the anti-dilution adjustments
described above, increase the maximum number of shares available for the grant
of options or increase the maximum number of shares covered by options that may
be granted to an employee in any calendar year, (b) materially increase the
benefits accruing to participants, or (c) change the eligibility requirements
for persons who may receive options. No termination or amendment may adversely
affect the rights of an optionee with respect to an outstanding option without
the optionee's consent.

FEDERAL INCOME TAX TREATMENT

         The following is a general summary of the federal income tax
consequences under current tax law of NQSOs and ISOs. It does not purport to
cover all of the special rules, including special rules relating to optionees
subject to Section 16(b) of the Exchange Act and the exercise of an option with
previously-acquired shares, or the state or local income or other tax
consequences inherent in the ownership and exercise of stock options and the
ownership and disposition of the underlying shares.

         An optionee will not recognize taxable income for federal income tax
purposes upon the grant of a NQSO or an ISO.

         Upon the exercise of a NQSO, the optionee will recognize ordinary
income in an amount equal to the excess, if any, of the fair market value of the
shares acquired on the date of exercise over the exercise price thereof, and the
Company will generally be entitled to a deduction for such amount at that time.
If the optionee later sells shares acquired pursuant to the exercise of a NQSO,
he or she will recognize long-term or short-term capital gain or loss, depending
on the period for which the shares were held. Long-term capital gain is
generally subject to more favorable tax treatment than ordinary income or
short-term capital gain.

         Upon the exercise of an ISO, the optionee will not recognize taxable
income. If the optionee disposes of the shares acquired pursuant to the exercise
of an ISO more than two years after the date of grant and more than one year
after the transfer of the shares to him or her, the optionee will recognize
long-term capital gain or loss and the Company will not be entitled to a
deduction. However, if the optionee disposes of such shares within the required
holding period, all or a portion of the gain will be treated as ordinary income
and the Company will generally be entitled to deduct such amount.

         In addition to the federal income tax consequences described above, an
optionee may be subject to the alternative minimum tax, which is payable to the
extent it exceeds the optionee's regular tax. For this purpose, upon the
exercise of an ISO, the excess of the fair market value of the shares over the
exercise price therefor is an adjustment which increases alternative minimum
taxable income. In addition, the optionee's basis in such shares is increased by
such excess for purposes of computing the gain or loss on the disposition of the
shares for alternative minimum tax purposes. If an optionee is required to pay
an alternative minimum tax, the amount of such tax which is attributable to
deferral preferences (including the ISO adjustment) is allowed as a credit


                                      -15-
<PAGE>   18

against the optionee's regular tax liability in subsequent years. To the extent
the credit is not used, it is carried forward.

OPTIONS GRANTED DURING LAST FISCAL YEAR TO EMPLOYEES AND CONSULTANTS

         The grant of options is within the discretion of the Committee.
Accordingly, the Company is unable to determine future options, if any, that may
be granted to the persons or groups to which the following table pertains. Set
forth under the caption "Executive Compensation - Option Grants in Last Fiscal
Year", above, is information., concerning options granted during the Company's
fiscal year ended December 31, 1999 to the persons named in the Summary
Compensation Table, each of which options was granted under the 1996 Plan. The
following table sets forth the number of shares underlying options that were
granted under the 1996 Plan (in the case of options granted to non-executive
officer directors, under the Company's 1993 Non-Employee Director Stock Option
Plan) during the Company's fiscal year ended December 31, 1999 to (i) all
current executive officers as a group, and (ii) all other employees, including
current officers who are not executive Officers (non-employee directors of the
Company are not entitled to participate in the 2000 Plan):

<TABLE>
<CAPTION>
                                                                                     NUMBER OF SHARES
                       CATEGORY OF OPTIONEE                                     UNDERLYING OPTIONS GRANTED

<S>                                                                                     <C>
Executive officers as a group (7 persons, including the persons                         1,260,000
named in the Summary Compensation Table)
Other employees as a group (25 persons)                                                   545,000
</TABLE>

         The exercise price of all options granted was at least 100% of the
market value of the underlying shares on the date of grant. The foregoing table
does not include any dollar value that may arise from a future increase in the
market value of the Company's Class A Common Stock. On April 20, 2000, the
closing price of the Company's Class A Common Stock on OTC Bulletin Board was
$____ per share.

REQUIRED VOTE

         Approval of the 2000 Plan requires the affirmative vote of both (a) a
majority of the shares of outstanding shares of Class A Common Stock and Class B
Common Stock, voting together as one class, with Class A Common Stock having one
vote per share and Class B Common Stock having ten votes per share and (b) a
majority of outstanding shares of Class A Common Stock voting as a separate
class, with each share of Class A Common Stock having one vote per share. If the
2000 Plan is not approved by stockholders, the 2000 Plan will terminate. The
Board of Directors recommends a Vote FOR approval of this proposal.

                                   PROPOSAL 3.

                         PROPOSAL TO APPROVE AMENDMENTS
                       TO THE COMPANY'S 1993 NON-EMPLOYEE
                           DIRECTOR STOCK OPTION PLAN

         At the Company's 1993 annual meeting, stockholders approved the
Company's 1993 Stock Option Plan (as amended, the "Non-Employee Director Plan")
for the purpose of granting options, within the limits and subject to the terms
and conditions of the plan, to directors who are not employees of the Company
("Outside Directors"). The Board of Directors believes that the Non-Employee
Director Plan has been instrumental in attracting and retaining Outside
Directors and that this objective will be furthered by amending the Non-Employee
Director Plan in the manner described below.

         On April 4, 2000, the Board unanimously adopted and recommended to
stockholders for approval amendments to the Non-Employee Director Plan (the
"Proposed Amendments") which provide: (i) all previously granted options and all
options granted in the future under the Non-Employee Director Plan vest in full
immediately following their grant in lieu of annual vesting at the rate of 25%
per annum on the first four


                                      -16-
<PAGE>   19

anniversaries of the date of grant; (ii) the term of all previously granted
options and all options granted in the future under the Non-Employee Director
Plan be for a term of ten years in lieu of five years; and (iii) the period
following termination of service during which an Outside Director may exercise
an option previously granted or granted in the future shall be twelve months in
lieu of three months, except that an option shall automatically terminate upon
cessation of service as an Outside Director for cause (such twelve month period
being the same period following an Outside Director's death or disability during
which an option may be exercised).

DESCRIPTION OF THE NON-EMPLOYEE DIRECTOR PLAN

         The Non-Employee Director Plan authorizes the grant of options to
purchase a maximum of 500,000 shares of Class A Common stock (subject to
potential adjustment in the event of stock dividends, splits, combinations and
recapitalizations and certain other events) to directors who are not employees
of the Company. No options may be granted under the Non-Employee Director Plan
after April 5, 2003. Upon the expiration, cancellation or termination of
unexercised options, the shares subject thereto will again be available for
grant under the Non-Employee Director Plan. The Non-Employee Director Plan is
administered by the Board of Directors subject to the provisions of the
Non-Employee Director Plan. Participation in the Non-Employee Director Plan is
limited to Outside Directors.

         As presently constituted, the Non-Employee Director Plan provides for
the granting immediately following the Meeting of an option to purchase 10,000
shares of Class A Common Stock to each Outside Director who is an Outside
Director immediately following each annual meeting of stockholders, commencing
with the Company's 1993 annual meeting of stockholders and the granting of an
option to purchase 10,000 shares of Common Stock to each person who thereafter
becomes an Outside Director on the date such person becomes an Outside Director.

         The option exercise price of each option under the Non-Employee
Director Plan is 100% of the fair market value of the Class A Common Stock on
the date of grant. Upon exercise of the option, the exercise price is to be paid
in full in cash.

OPTIONS RECENTLY GRANTED UNDER THE NON-EMPLOYEE DIRECTOR PLAN

         Immediately following the 1999 Annual Meeting of Stockholders on June
15, 1999, options to purchase 10,000 shares were granted to each of Mr. Born,
Ms. Crooks, Mr. Hogan and Mr. Sharwell, the Company's then non-employee
directors, at an exercise price of $1.09 per share, the fair market value of the
Company's Class A Common Stock on the Nasdaq National Market on that date.

REQUIRED VOTE

         Approval of the amendments to the Non-Employee Director Plan requires
the affirmative vote of both (a) a majority of the shares of outstanding shares
of Class A Common Stock and Class B Common Stock, voting together as one class,
with Class A Common Stock having one vote per share and Class B Common Stock
having ten votes per share and (b) a majority of outstanding shares of Class A
Common Stock voting as a separate class, with each share of Class A Common Stock
having one vote per share. If the proposed amendments are not approved by
stockholders, the Non-Employee Director Plan will continue in its present form.
The Board of Directors unanimously recommends that stockholders vote FOR this
proposal.

                                   PROPOSAL 4.

                RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS

         The Board of Directors has selected the firm of Arthur Andersen LLP as
the independent auditors of the Company for the year ending December 31, 2000.
Arthur Andersen LLP has acted for the Company in such capacity since 1989. The
Board proposes that the stockholders ratify such selection at the Meeting.


                                      -17-
<PAGE>   20

         Representatives of Arthur Andersen LLP are expected to be present at
the Meeting and will be afforded an opportunity to make a statement if they so
desire and to respond to appropriate questions.

REQUIRED VOTE

         The affirmative vote of a majority of the shares of Class A Common
Stock and Class B Common Stock present, in person or by proxy, at the Meeting
and entitled to vote on this proposal, voting together as one class, with Class
A Common Stock having one vote per share and Class B Common Stock having ten
votes per share, will be required to adopt this proposal. The Board of Directors
recommends that stockholders vote FOR approval of this proposal.

                                  MISCELLANEOUS

STOCKHOLDER PROPOSALS

         From time to time stockholders may present proposals which may be
proper subjects for inclusion in the proxy statement and form of proxy relating
to that meeting. In order to be considered, such proposals must be submitted in
writing on a timely basis. Stockholder proposals intended to be included in the
Board of Directors' proxy statement and form of proxy relating to the Company's
next Annual Meeting of Stockholders must be received by December 31, 2000. As to
any proposals intended to be presented by a stockholder without inclusion in the
Board of Directors' proxy statement and form of proxy for the Company's next
Annual Meeting of Stockholders, the proxies named in the Board of Directors'
form of proxy for that meeting will be entitled to exercise discretionary
authority on that proposal unless the Company receives notice of the matter on
or before April 2, 2001. However, even if such notice is timely received, such
proxies nevertheless may be entitled to exercise discretionary authority on that
matter to the extent permitted by Securities and Exchange Commission
regulations. Any such proposals, as well as any questions relating thereto,
should be directed to the Secretary of the Company at 1375 Akron Street,
Copiague, New York 11726.

ANNUAL REPORT ON FORM 10-K

         A copy of the Company's Annual Report on Form 10-K for the year ended
December 31, 1999, which has been filed with the Securities and Exchange
Commission, is also available, without charge, to stockholders who are
interested in more detailed information about the Company. Requests for a copy
of that report should be addressed to Josef C. Schoell, Vice President-Finance,
at 1375 Akron Street, Copiague, New York 11726.

                                        By Order of the Board of Directors,

                                        Timothy J. Roach
                                        Secretary
May 1, 2000


                                      -18-
<PAGE>   21


                                                                       Exhibit A
                             2000 STOCK OPTION PLAN

                                       OF

                       AMERICAN BIOGENETIC SCIENCES, INC.

         1. PURPOSES OF THE PLAN. This stock option plan (the "Plan") is
designed to provide an incentive to employees (including directors and officers
who are employees) and to consultants who are not employees of American
Biogenetic Sciences, Inc., a Delaware corporation (the "Company"), and its
present and future subsidiary corporations, as defined in Paragraph 19
("Subsidiaries"), and to offer an additional inducement in obtaining the
services of such employees and consultants. The Plan provides for the grant of
"incentive stock options" ("ISOs") within the meaning of Section 422 of the
Internal Revenue Code of 1986, as amended (the "Code"), and nonqualified stock
options which do not qualify as ISOs ("NQSOs"), but the Company makes no
representation or warranty, express or implied, as to the qualification of any
option as an "incentive stock option" under the Code.

         2. STOCK SUBJECT TO THE PLAN. Subject to the provisions of Paragraph
12, the aggregate number of shares of Class A Common Stock, $.001 par value per
share, of the Company ("Common Stock") for which options may be granted under
the Plan shall not exceed 3,000,000. Such shares of Common Stock may, in the
discretion of the Board of Directors of the Company (the "Board of Directors"),
consist either in whole or in part of authorized but unissued shares of Common
Stock or shares of Common Stock held in the treasury of the Company. Subject to
the provisions of Paragraph 13, any shares of Common Stock subject to an option
which for any reason expires, is canceled or is terminated unexercised or which
ceases for any reason to be exercisable shall again become available for the
granting of options under the Plan. The Company shall at all times during the
term of the Plan reserve and keep available such number of shares of Common
Stock as will be sufficient to satisfy the requirements of the Plan.

         3. ADMINISTRATION OF THE PLAN. The Plan shall be administered by the
Board of Directors or, to the extent the Board of Directors may determine, a
committee of the Board of Directors (the "Committee") consisting of not less
than two directors, each of whom shall be a "non-employee director" within the
meaning of Rule 16b-3 (or any successor rule or regulation) promulgated under
the Securities Exchange Act of 1934, as amended (as the same may be in effect
and interpreted from time to time, "Rule 16b-3"). A majority of the members of
the Committee shall constitute a quorum, and the acts of a majority of the
members present at any meeting at which a quorum is present, and any acts
approved in writing by all members without a meeting, shall be the acts of the
Committee. All references in the Plan to determinations or actions of the
Committee shall be deemed to include determinations and actions by the Committee
or the Board of Directors.

         Subject to the express provisions of the Plan, the Committee shall have
the authority, in its sole discretion, to determine the employees and the
consultants who shall be granted options; the times when options shall be
granted; whether an option granted to an employee shall be an ISO or a NQSO; the
number of shares of Common Stock to be subject to each option; the term of each
option; the date each option shall become exercisable; whether an option shall
be exercisable in whole, in part or in installments and, if in installments, the
number of shares of Common Stock to be subject to each installment, whether the
installments shall be cumulative, the date each installment shall become
exercisable and the term of each installment; whether to accelerate the date of
exercise of any option or installment; whether shares of Common Stock may be
issued upon the exercise of an option as partly paid and, if so, the dates when
future installments of the exercise price shall become due and the amounts of
such installments; the exercise price of each option; the form of payment of the
exercise price; the fair market value of a share of Common Stock; whether to
restrict the sale or other disposition of the shares of Common Stock acquired
upon the exercise of an option and, if so, whether to waive any such
restriction; whether to subject the exercise of all or any portion of an option
to the fulfillment of contingencies as specified in the contract referred to in
Paragraph 11 (the "Contract"), including without limitation, contingencies
relating to entering into a covenant not to compete


                                      -19-
<PAGE>   22

with the Company, any of its Subsidiaries or a Parent (as defined in Paragraph
19), to financial objectives for the Company, any of its Subsidiaries or a
Parent, a division of any of the foregoing, a product line or other category,
and/or the period of continued employment of the optionee with the Company, any
of its Subsidiaries or a Parent, and to determine whether such contingencies
have been met; the amount, if any, necessary to satisfy the Company's obligation
to withhold taxes or other amounts; whether an optionee is Disabled (as defined
in Paragraph 19); to construe the respective Contracts and the Plan; with the
consent of the optionee, to cancel or modify an option, PROVIDED such modified
provision would be permitted to be included in an option on the date of
modification, and FURTHER, PROVIDED, that, in the case of a modification (within
the meaning of Section 424(h) of the Code) of an ISO, such option as modified
would be permitted to be granted on the date of such modification under the
terms of the Plan; to prescribe, amend and rescind rules and regulations
relating to the Plan; and to make all other determinations necessary or
advisable for administering the Plan. Any controversy or claim arising out of or
relating to the Plan, any option granted under the Plan or any Contract shall be
determined unilaterally by the Committee in its sole discretion. The
determinations of the Committee on the matters referred to in this Paragraph 3
shall be conclusive and binding on the parties. No member or former member of
the Committee shall be liable for any action, failure to act or determination
made in good faith with respect to the Plan or any option hereunder.

         4. ELIGIBILITY. The Committee may from time to time, in its sole
discretion, consistent with the purposes of the Plan, grant options to employees
(including officers and directors who are employees) of, and to consultants to,
the Company or any of its Subsidiaries. Such options granted shall cover such
number of shares of Common Stock as the Committee may determine in its sole
discretion; PROVIDED, HOWEVER, that the maximum number of shares subject to
options that may be granted to any employee during any calendar year under the
Plan (the "162(m) Maximum") shall not exceed 500,000 shares; and FURTHER,
PROVIDED, that the aggregate market value (determined at the time the option is
granted in accordance with Paragraph 5) of the shares of Common Stock for which
any eligible employee may be granted ISOs under the Plan or any other plan of
the Company, or of a Parent or a Subsidiary of the Company, which are
exercisable for the first time by such optionee during any calendar year shall
not exceed $100,000. Such limitation shall be applied by taking ISOs into
account in the order in which they were granted. Any option (or the portion
thereof) granted in excess of such amount shall be treated as an NQSO.

         5. EXERCISE PRICE. The exercise price of the shares of Common Stock
under each option shall be determined by the Committee in its sole discretion;
PROVIDED, HOWEVER, the exercise price of an ISO shall not be less than the fair
market value of the Common Stock subject to such option on the date of grant;
and FURTHER, PROVIDED, that if, at the time an ISO is granted, the optionee owns
(or is deemed to own under Section 424(d) of the Code) stock possessing more
than 10% of the total combined voting power of all classes of stock of the
Company, of any of its Subsidiaries or of a Parent, the exercise price of such
ISO shall not be less than 110% of the fair market value of the Common Stock
subject to such ISO on the date of grant.

         The fair market value of a share of Common Stock on any day shall be
(a) if the principal market for the Common Stock is a national securities
exchange, the average of the highest and lowest sales prices per share of Common
Stock on such day as reported by such exchange or on a composite tape reflecting
transactions on such exchange, (b) if the principal market for the Common Stock
is not a national securities exchange and the Common Stock is quoted on The
Nasdaq Stock Market ("Nasdaq"), (i) if closing bid and asked price information
is available with respect to the Common Stock, the average of the closing bid
and asked prices per share of Common Stock on such day on Nasdaq, or (ii) if
such information is not available, the average of the highest bid and lowest
asked prices per share of Common Stock on such day on Nasdaq, or (c) if the
principal market for the Common Stock is not a national securities exchange and
the Common Stock is not quoted on Nasdaq, the average of the highest bid and
lowest asked prices per share of Common Stock on such day as reported on the OTC
Bulletin Board Service or by National Quotation Bureau, Incorporated or a
comparable service; PROVIDED, HOWEVER, that if clauses (a), (b) and (c) of this
Paragraph are all inapplicable, or if no trades have been made or no quotes are
available for such day, the fair market value of the Common Stock shall be
determined by the Board by any method consistent with applicable regulations
adopted by the Treasury Department relating to stock options.


                                      -20-
<PAGE>   23

         6. TERM. The term of each option granted pursuant to the Plan shall be
such term as is established by the Committee, in its sole discretion; PROVIDED,
HOWEVER, that the term of each ISO granted pursuant to the Plan shall be for a
period not exceeding 10 years from the date of grant thereof; and FURTHER,
PROVIDED, that if, at the time an ISO is granted, the optionee owns (or is
deemed to own under Section 424(d) of the Code) stock possessing more than 10%
of the total combined voting power of all classes of stock of the Company, of
any of its Subsidiaries or of a Parent, the term of the ISO shall be for a
period not exceeding five years from the date of grant. Options shall be subject
to earlier termination as hereinafter provided.

         7. EXERCISE. An option (or any part or installment thereof), to the
extent then exercisable, shall be exercised by giving written notice to the
Company at its principal office stating which option is being exercised,
specifying the number of shares of Common Stock as to which such option is being
exercised and accompanied by payment in full of the aggregate exercise price
therefor (or the amount due on exercise if the Contract permits installment
payments) (a) in cash or by certified check or (b) if the applicable Contract
permits, with previously acquired shares of Common Stock having an aggregate
fair market value on the date of exercise (determined in accordance with
Paragraph 5) equal to the aggregate exercise price of all options being
exercised, or with any combination of cash, certified check or shares of Common
Stock

         The Committee may, in its sole discretion, permit payment of the
exercise price of an option by delivery by the optionee of a properly executed
notice, together with a copy of the optionee's irrevocable instructions to a
broker acceptable to the Committee to deliver promptly to the Company the amount
of sale or loan proceeds sufficient to pay such exercise price. In connection
therewith, the Company may enter into agreements for coordinated procedures with
one or more brokerage firms.

         A person entitled to receive Common Stock upon the exercise of an
option shall not have the rights of a stockholder with respect to such shares of
Common Stock until the date of issuance of a stock certificate to him for such
shares; PROVIDED, HOWEVER, that until such stock certificate is issued, any
optionee using previously acquired shares of Common Stock in payment of an
option exercise price shall continue to have the rights of a stockholder with
respect to such previously acquired shares.

         In no case may a fraction of a share of Common Stock be purchased or
issued under the Plan.

         8. TERMINATION OF RELATIONSHIP. Except as may otherwise be expressly
provided in the applicable Contract, any optionee whose relationship with the
Company, its Subsidiaries and Parent as an employee or consultant has terminated
for any reason (other than his death or Disability) may exercise such option, to
the extent exercisable on the date of such termination, at any time within three
months after the date of termination, but not thereafter and in no event after
the date the option would otherwise have expired; PROVIDED, HOWEVER, that if
such relationship is terminated either (a) for cause, or (b) without the consent
of the Company, such option shall terminate immediately.

         For the purposes of the Plan, an employment relationship shall be
deemed to exist between an individual and a corporation if, at the time of the
determination, the individual was an employee of such corporation for purposes
of Section 422(a) of the Code. As a result, an individual on military, sick
leave or other bona fide leave of absence shall continue to be considered an
employee for purposes of the Plan during such leave if the period of the leave
does not exceed 90 days, or, if longer, so long as the individual's right to
reemployment with the Company (or a related corporation) is guaranteed either by
statute or by contract. If the period of leave exceeds 90 days and the
individual's right to reemployment is not guaranteed by statute or by contract,
the employment relationship shall be deemed to have terminated on the 31st day
of such leave.

         Notwithstanding the foregoing, except as may otherwise be expressly
provided in the applicable Contract, options granted under the Plan shall not be
affected by any change in the status of the optionee so long as the optionee
continues to be an employee of, or a consultant to, the Company, any of its
Subsidiaries or a Parent (regardless of having changed from one to the other or
having been transferred from one corporation to another).


                                      -21-
<PAGE>   24

         Nothing in the Plan or in any option granted under the Plan shall
confer on any optionee any right to continue in the employ of, or as a
consultant to, the Company, its Parent or any of its Subsidiaries, or interfere
in any way with any right of the Company, its Parent or any of its Subsidiaries
to terminate the optionee's relationship at any time for any reason whatsoever
without liability to the Company, its Parent or any of its Subsidiaries.

         9. DEATH OR DISABILITY OF AN OPTIONEE. Except as may otherwise be
expressly provided in the applicable Contract, if an individual optionee dies
(a) while he is an employee of, or a consultant to, the Company, any of its
Subsidiaries or a Parent, (b) within three months after the termination of such
relationship (unless such termination was for cause or without the consent of
the Company) or (c) within one year following the termination of such
relationship by reason of Disability, his option may be exercised, to the extent
exercisable on the date of his death, by his Legal Representative (as defined in
Paragraph 19) at any time within one year after death, but not thereafter and in
no event after the date the option would otherwise have expired.

         Except as may otherwise be expressly provided in the applicable
Contract, any optionee whose relationship as an employee of, or a consultant to,
the Company, its Parent or any Subsidiary has terminated by reason of Disability
may exercise his option, to the extent exercisable upon the effective date of
such termination, at any time within one year after such date, but not
thereafter and in no event after the date the option would otherwise have
expired.

         10. COMPLIANCE WITH SECURITIES LAWS. It is a condition to the exercise
of any option that either (a) a Registration Statement under the Securities Act
of 1933, as amended (the "Securities Act"), with respect to the shares of Common
Stock to be issued upon such exercise shall be effective and current at the time
of exercise, or (b) there be an exemption from registration under the Securities
Act for the issuance of the shares of Common Stock upon such exercise. Nothing
herein shall be construed as requiring the Company to register shares subject to
any option under the Securities Act or to keep any Registration Statement
effective or current.

         The Committee may require, in its sole discretion, as a condition to
the exercise of any option that the optionee execute and deliver to the Company
his representations and warranties, in form, substance and scope satisfactory to
the Committee, which the Committee determines are necessary or convenient to
facilitate the perfection of an exemption from the registration requirements of
the Securities Act or other legal requirement, including without limitation that
(a) the shares of Common Stock to be issued upon the exercise of the option are
being acquired by the optionee for his own account, for investment only and not
with a view to the resale or distribution thereof, and (b) any subsequent resale
or distribution of shares of Common Stock by such optionee will be made only
pursuant to (i) a Registration Statement under the Securities Act which is
effective and current with respect to the shares of Common Stock being sold, or
(ii) a specific exemption from the registration requirements of the Securities
Act, but in claiming such exemption, the optionee shall prior to any offer of
sale or sale of such shares of Common Stock provide the Company with a favorable
written opinion of counsel satisfactory to the Company, in form, substance and
scope satisfactory to the Company, as to the applicability of such exemption to
the proposed sale or distribution.

         In addition, if at any time the Committee shall determine, in its sole
discretion, that the listing or qualification of the shares of Common Stock
subject to such option on any securities exchange, Nasdaq or under any
applicable law, or the consent or approval of any governmental regulatory body,
is necessary or desirable as a condition to, or in connection with, the granting
of an option or the issue of shares of Common Stock thereunder, such option may
not be exercised in whole or in part unless such listing, qualification, consent
or approval shall have been effected or obtained free of any conditions not
acceptable to the Committee.

         11. STOCK OPTION CONTRACTS. Each option shall be evidenced by an
appropriate Contract which shall be duly executed by the Company and the
optionee, and shall contain such terms, provisions and conditions not
inconsistent herewith as may be determined by the Committee.


                                      -22-
<PAGE>   25

         12. ADJUSTMENTS UPON CHANGES IN COMMON STOCK. Notwithstanding any other
provision of the Plan, in the event of a stock dividend, split-up, combination,
reclassification, recapitalization, spin-off, merger in which the Company is the
surviving corporation, or exchange of shares or the like which results in a
change in the number or kind of those shares of Common Stock which are
outstanding immediately prior to such event, the aggregate number and kind of
shares subject to the Plan, the aggregate number and kind of shares subject to
each outstanding option and the exercise price thereof, and the 162(m) Maximum
shall be appropriately adjusted by the Board of Directors, whose determination
shall be conclusive and binding on all parties. Such adjustment may provide for
the elimination of fractional shares which might otherwise be subject to options
without payment thereto.

         In the event of (a) the liquidation or dissolution of the Company, or
(b) a merger in which the Company is not the surviving corporation or a
consolidation, any outstanding options shall terminate upon the earliest of any
such event, unless other provision is made therefor in the transaction.

         13. AMENDMENTS AND TERMINATION OF THE PLAN. The Plan was adopted by the
Board of Directors as of March 31, 2000. No option may be granted under the Plan
after March 30, 2010. The Board of Directors, without further approval of the
Company's stockholders, may at any time suspend or terminate the Plan, in whole
or in part, or amend it from time to time in such respects as it may deem
advisable, including, without limitation, in order that ISOs granted hereunder
meet the requirements for "incentive stock options" under the Code, to comply
with, conform to or adopt the provisions of Rule 16b-3, Section 162(m) of the
Code or any change in applicable law, regulations, rulings or interpretations of
administrative agencies; PROVIDED, HOWEVER, that no amendment shall be effective
without the requisite prior or subsequent stockholder approval which would (a)
except as contemplated in Paragraph 12, increase the maximum number of shares of
Common Stock for which options may be granted under the Plan or the 162(m)
Maximum, (b) materially increase the benefits accruing to participants under the
Plan or (c) change the eligibility requirements to receive options hereunder. No
termination, suspension or amendment of the Plan shall, without the consent of
the holder of an existing and outstanding option affected thereby, adversely
affect his rights under such option. The power of the Committee to construe and
administer any options granted under the Plan prior to the termination or
suspension of the Plan nevertheless shall continue after such termination or
during such suspension.

         14. NON-TRANSFERABILITY OF OPTIONS. No option granted under the Plan
shall be transferable otherwise than by will or the laws of descent and
distribution, and options may be exercised, during the lifetime of the optionee,
only by the optionee or his Legal Representatives. Except to the extent provided
above, options may not be assigned, transferred, pledged, hypothecated or
disposed of in any way (whether by operation of law or otherwise) and shall not
be subject to execution, attachment or similar process, and any such attempted
assignment, transfer, pledge, hypothecation or disposition shall be null and
void AB INITIO and of no force or effect.

         15. WITHHOLDING TAXES. The Company shall withhold cash in an amount
equal to the amount determined necessary to satisfy the Company's obligation to
withhold Federal, state and local income taxes or other amounts incurred by
reason of the grant or exercise of an option or the disposition of the
underlying shares of Common Stock except to the extent that, with the specific
authorization of the Committee, in the Contract or otherwise, the optionee is
permitted to pay such amounts by (a) the delivery or withholding of shares of
Common Stock having an aggregate fair market value on the exercise date
(determined in accordance with Paragraph 5) or (b) any combination of cash and
such shares. Alternatively, the Company may require the holder to pay to the
Company such amount, in cash, promptly upon demand. The Company shall not be
required to issue any shares of Common Stock pursuant to any such option until
all required payments have been made.

         16. LEGENDS; PAYMENT OF EXPENSES. The Company may endorse such legend
or legends upon the certificates for shares of Common Stock issued upon exercise
of an option under the Plan and may issue such "stop transfer" instructions to
its transfer agent in respect of such shares as it determines, in its
discretion, to be necessary or appropriate to (a) prevent a violation of, or to
perfect an exemption from, the registration requirements of the Securities Act
and any applicable state securities laws, (b) implement the


                                      -23-
<PAGE>   26

provisions of the Plan or any agreement between the Company and the optionee
with respect to such shares of Common Stock, or (c) permit the Company to
determine the occurrence of a "disqualifying disposition," as described in
Section 421(b) of the Code, of the shares of Common Stock issued or transferred
upon the exercise of an ISO granted under the Plan.

         The Company shall pay all issuance taxes with respect to the issuance
of shares of Common Stock upon the exercise of an option granted under the Plan,
as well as all fees and expenses incurred by the Company in connection with such
issuance.

         17. USE OF PROCEEDS. The cash proceeds from the sale of shares of
Common Stock pursuant to the exercise of options under the Plan shall be added
to the general funds of the Company and used for such corporate purposes as the
Board of Directors may determine.

         18. SUBSTITUTIONS AND ASSUMPTIONS OF OPTIONS OF CERTAIN CONSTITUENT
CORPORATIONS. Anything in this Plan to the contrary notwithstanding, the Board
of Directors may, without further approval by the stockholders, substitute new
options for prior options of a Constituent Corporation (as defined in Paragraph
19) or assume the prior options of such Constituent Corporation.

         19. DEFINITIONS. For purposes of the Plan, the following terms shall be
 defined as set forth below:

                  (a) Constituent Corporation. The term "Constituent
Corporation" shall mean any corporation which engages with the Company, any of
its Subsidiaries or a Parent in a transaction to which Section 424(a) of the
Code applies (or would apply if the option assumed or substituted were an ISO),
or any Parent or any Subsidiary of such corporation.

                  (b) Disability. The term "Disability" shall mean a permanent
and total disability within the meaning of Section 22(e)(3) of the Code.

                  (c) Legal Representative. The term "Legal Representative"
shall mean the executor, administrator or other person who at the time is
entitled by law to exercise the rights of a deceased or incapacitated optionee
with respect to an option granted under the Plan.

                  (d) Parent. The term "Parent" shall have the same definition
as "parent corporation" in Section 424(e) of the Code.

                  (e) Subsidiary. The term "Subsidiary" shall have the same
definition as "subsidiary corporation" in Section 424(f) of the Code.

         20. GOVERNING LAW; CONSTRUCTION. The Plan, such options as may be
granted hereunder and all related matters shall be governed by, and construed in
accordance with, the laws of the State of Delaware, without regard to conflict
of law provisions.

         Neither the Plan nor any Contract shall be construed or interpreted
with any presumption against the Company by reason of the Company causing the
Plan or Contract to be drafted. Whenever from the context it appears
appropriate, any term stated in either the singular or plural shall include the
singular and plural, and any term stated in the masculine, feminine or neuter
gender shall include the masculine, feminine and neuter.

         21. PARTIAL INVALIDITY. The invalidity, illegality or unenforceability
of any provision in the Plan or any Contract shall not affect the validity,
legality or enforceability of any other provision, all of which shall be valid,
legal and enforceable to the fullest extent permitted by applicable law.

         22. STOCKHOLDER APPROVAL. The Plan shall be subject to approval by a
majority of the votes present in person or by proxy at the next duly held
meeting of the Company's stockholders at which a quorum is present. No options
granted hereunder may be exercised prior to such approval; PROVIDED, HOWEVER,
that the


                                      -24-
<PAGE>   27

date of grant of any option shall be determined as if the Plan had not been
subject to such approval. Notwithstanding the foregoing, if the Plan is not
approved by a vote of the stockholders of the Company on or before March 30,
2001, the Plan and any options granted hereunder shall terminate.


                                      -25-
<PAGE>   28


                       AMERICAN BIOGENETIC SCIENCES, INC.
            PROXY FOR ANNUAL MEETING OF STOCKHOLDERS - JUNE 13, 2000

           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

           The undersigned hereby appoints, as proxies for the undersigned, AIDA
PADILLA, TIMOTHY J. ROACH and LEONARD W. SUROFF, or any one or more of them,
with full power of substitution, to vote all shares of the capital stock of
American Biogenetic Sciences, Inc. (the "Company") which the undersigned is
entitled to vote at the Annual Meeting of Stockholders of the Company to be held
on Tuesday, June 13, 2000, at 3:00 p.m., Eastern Daylight Savings Time, at The
Huntington Hilton, 598 Broadhollow Road, Melville, New York, and at any
adjournments or postponements thereof, receipt of Notice of which meeting and
the Proxy Statement accompanying the same being hereby acknowledged by the
undersigned, upon the matters described in the Notice of Meeting and Proxy
Statement and upon such other business as may properly come before the meeting
and any adjournments or postponements thereof, hereby revoking any proxies
heretofore given.

           Each properly executed proxy will be voted in accordance with the
specifications made below and on the reverse side hereof. If no specifications
are made, the proxies will be voted FOR each listed nominee to serve as a
director and FOR Proposals 2, 3, 4 and 5.

           A vote FOR each nominee and FOR Proposals 2 , 3, 4 and 5 is
recommended by the Board of Directors.

  1.       Election of Directors (check one box only)

                      [ ]                                      [ ]

        FOR EACH NOMINEE LISTED BELOW                   WITHHOLD AUTHORITY
        (except as marked to the contrary below)        to vote for all nominees
                                                        listed below

              ALFRED J. ROACH, JOHN S. NORTH, ELLENA M. BYRNE, TIMOTHY J. ROACH,
              GUSTAV V.R. BORN, GLENNA M. CROOKS and JOSEPH C. HOGAN

(Instruction:  To withhold authority to vote for any nominee, circle that
nominee's name in the above list)

                                    (continued and to be signed on reverse side)


<PAGE>   29


  2.       To approve the Company's 2000 Stock Option Plan.

                                   FOR              AGAINST            ABSTAIN

                                   [ ]                [ ]                [ ]

  3.       To approve an amendments to the Company's 1993 Non-Employee Director
           Stock Option Plan.

                                   FOR              AGAINST            ABSTAIN

                                   [ ]                [ ]                [ ]


  4.       To ratify the selection of Arthur Andersen LLP as independent
           auditors for the Company.

                                   FOR              AGAINST            ABSTAIN

                                   [ ]                [ ]                [ ]



                                      Dated:                              , 2000
                                            ------------------------------


                                      ------------------------------------------
                                      (SIGNATURE OF STOCKHOLDER)


                                      ------------------------------------------
                                      (SIGNATURE OF STOCKHOLDER)

                                      NOTE: PLEASE SIGN YOUR NAME OR NAMES
                                      EXACTLY AS SET FORTH HEREON. FOR JOINTLY
                                      OWNED SHARES, EACH OWNER SHOULD SIGN. IF
                                      SIGNING AS ATTORNEY, EXECUTOR,
                                      ADMINISTRATOR, TRUSTEE OR GUARDIAN, PLEASE
                                      INDICATE THE CAPACITY IN WHICH YOU ARE
                                      ACTING. PROXIES EXECUTED BY CORPORATIONS
                                      SHOULD BE SIGNED BY A DULY AUTHORIZED
                                      OFFICER AND SHOULD BEAR THE CORPORATE
                                      SEAL.

              PLEASE DATE AND SIGN THIS PROXY AND MAIL IT PROMPTLY
           IN THE ENCLOSED ENVELOPE. NO POSTAGE IS REQUIRED IF MAILED
                              IN THE UNITED STATES.


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