DYNAGEN INC
S-3/A, 1999-09-09
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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    AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON SEPTEMBER 9, 1999
                                                      Registration No. 333-82785

================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                               ------------------

                               AMENDMENT NO. 1 TO
                                    FORM S-3
             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

                               ------------------

                                  DYNAGEN, INC.
             (Exact name of registrant as specified in its charter)

             DELAWARE                                         04-3029787
   (State or other jurisdiction                            (I.R.S. employer
  of incorporation or organization)                     identification number)


                         1000 WINTER STREET, SUITE 2700
                          WALTHAM, MASSACHUSETTS 02451
                                 (781) 890-0021
    (Address, including zip code, and telephone number, including area code,
                  of registrant's principal executive offices)

                               ------------------

                                C. ROBERT CUSICK
                      PRESIDENT AND CHIEF EXECUTIVE OFFICER
                                  DYNAGEN, INC.
                         1000 WINTER STREET, SUITE 2700
                          WALTHAM, MASSACHUSETTS 02451
                                 (781) 890-0021
            (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)

                               ------------------

                                   Copies to:
                             DAVID A. BROADWIN, ESQ.
                             FOLEY, HOAG & ELIOT LLP
                             ONE POST OFFICE SQUARE
                           BOSTON, MASSACHUSETTS 02109
                                 (617) 832-1259

                               ------------------

      Approximate date of commencement of proposed sale to the public: As soon
as practicable after this Registration Statement becomes effective.
      If the only securities being registered on this Form are being offered
pursuant to dividend or interest reinvestment plans, please check the following
box. [ ]
      If any of the securities being registered on this Form are to be offered
on a delayed or continuous basis pursuant to Rule 415 under the Securities Act
of 1933, other than securities offered only in connection with dividend or
interest reinvestment plans, check the following box. [X]
      If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. [ ]_________
      If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [ ]_________
      If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. [ ]
<TABLE>
<CAPTION>

                         CALCULATION OF REGISTRATION FEE
==============================================================================================================
                                                         PROPOSED           PROPOSED
                                        AMOUNT           MAXIMUM             MAXIMUM
    TITLE OF EACH CLASS OF              TO BE         OFFERING PRICE        AGGREGATE            AMOUNT OF
  SECURITIES TO BE REGISTERED         REGISTERED       PER SHARE(1)     OFFERING PRICE(1)    REGISTRATION FEE
==============================================================================================================
<S>                                   <C>              <C>              <C>                    <C>
Common Stock, $.01 par value ......    7,237,529          $.49            $3,546,389.21         $985.90(2)
==============================================================================================================
</TABLE>
(1)  Estimated solely for the purposes of determining the registration fee. In
     accordance with Rule 457(c) under the Securities Act of 1933, the above
     calculation is based on average of the high and low prices reported on the
     OTC Bulletin Board on September 2, 1999.
(2)  $1,139.37 previously paid by wire transfer on July 13, 1999.

                               ------------------

      THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME
EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(A),
MAY DETERMINE.
================================================================================

<PAGE>

                 SUBJECT TO COMPLETION, DATED SEPTEMBER 9, 1999


                                   PROSPECTUS


                                  DYNAGEN, INC.


                                7,237,529 SHARES

                                  COMMON STOCK


     The selling stockholders are offering 7,237,529 shares of common stock. We
will not receive any of the proceeds from sales of shares by the selling
stockholders.

     The selling stockholders may sell these shares from time to time in the
over-the-counter market, on the Boston Stock Exchange or otherwise.

     DynaGen's common stock is traded on the Boston Stock Exchange under the
symbol "DYG" and quoted on the OTC Bulletin Board under the symbol "DYGN." The
last reported sale price of the common stock on the OTC Bulletin Board on
September 2, 1999 was $.50 per share.


                         ------------------------------

                  INVESTING IN THE COMMON STOCK INVOLVES RISKS.
                     SEE "RISK FACTORS" BEGINNING ON PAGE 5.

                         ------------------------------


     THE SECURITIES AND EXCHANGE COMMISSION AND STATE SECURITIES REGULATORS HAVE
NOT APPROVED OR DISAPPROVED THESE SECURITIES, OR DETERMINED IF THIS PROSPECTUS
IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL
OFFENSE.

                The date of this prospectus is September 9, 1999.

<PAGE>

     YOU SHOULD RELY ONLY ON THE INFORMATION CONTAINED IN THIS DOCUMENT OR TO
WHICH WE HAVE REFERRED YOU. WE HAVE NOT AUTHORIZED ANYONE TO PROVIDE YOU WITH
INFORMATION THAT IS DIFFERENT. THIS DOCUMENT MAY BE USED ONLY WHERE IT IS LEGAL
TO SELL THESE SECURITIES. THE INFORMATION IN THIS DOCUMENT IS ACCURATE ONLY AS
OF THE DATE OF THIS DOCUMENT, REGARDLESS OF THE TIME OF THE DELIVERY OF THIS
PROSPECTUS OR OF ANY SALE OF OUR COMMON STOCK.

                         ------------------------------

                                TABLE OF CONTENTS
                                                                          PAGE
                                                                         ------
Summary..................................................................   3
Risk Factors.............................................................   5

Use of Proceeds..........................................................   9
Dividend Policy..........................................................   9
Selling Stockholders.....................................................   9
Plan of Distribution.....................................................  11
Legal Matters............................................................  12
Experts..................................................................  12
Disclosure of SEC Position on Indemnification
     for Securities Act Liabilities .... ................................  12
Where You Can Find More Information......................................  12

     We own or have rights to various trademarks and trade names used in our
business. These include DynaGen, Able, Superior, GDI, and others. This
prospectus also refers to trademarks and trade names of other companies.



                                        2
<PAGE>
                                     SUMMARY

     Because this is only a summary, it does not contain all the information
that may be important to you. You should read the entire prospectus carefully
before you decide to purchase the shares of common stock being offered by this
prospectus. You should also carefully consider the information provided in this
prospectus under the heading "Risk Factors."


                                     DYNAGEN

INTRODUCTION:      We develop, manufacture and distribute generic drugs. From
                   our inception in 1988 until 1996, we focused primarily on
                   developing new drugs and licensing the resulting products and
                   technologies to others. Beginning in 1996, we began
                   redirecting our business focus to building a generic drug
                   distribution business.

THE MULTISOURCE
GENERIC                DRUG BUSINESS: Generic drugs compete with brand-name
                       drugs for which patent protection or other
                       government-mandated market exclusivity has expired.
                       Generic drugs are the chemical and therapeutic
                       equivalents of brand-name drugs. They are required to
                       meet the same governmental standards as the brand-name
                       drugs they replace, and they must meet all FDA
                       guidelines. Generic drugs are typically sold under their
                       generic chemical names at prices significantly below
                       those of their brand-name equivalents. We estimate that
                       the U.S. market for generic drugs approximates $12
                       billion in annual sales. This market has grown due to a
                       number of factors, including:

                       o  a significant number of widely-prescribed brand-name
                          drugs are at or near the end of their period of patent
                          protection, making it possible for generic
                          manufacturers to produce and market competing generic
                          drugs;

                       o  managed care organizations, which prefer lower-cost
                          generics to brand-name products, are capturing a
                          greater share of the healthcare market; and

                       o  physicians, pharmacists and consumers are increasingly
                          accepting generic drugs as an alternative to
                          brand-name drugs.

OUR BUSINESS:      We intend to compete with other generic drug companies by
                   combining two key elements of the business: manufacturing and
                   distribution. We have acquired three operating subsidiaries
                   to carry out this plan:

                   Able Labs:  In August 1996, we acquired Able Laboratories,
                               Inc., including its 46,000-square foot tablet and
                               suppository manufacturing facility in South
                               Plainfield, New Jersey. As part of the
                               acquisition of Able, we obtained rights to eleven
                               FDA-approved Abbreviated New Drug Applications
                               for generic drug products. We are currently
                               marketing three of these acquired products.

                   Superior:   In June 1997, we acquired Superior Pharmaceutical
                               Company, a generic drug distributor in
                               Cincinnati, Ohio. Since we acquired it, Superior
                               has experienced a sharp and steady decline in its
                               sales and margins. Superior lost several key
                               personnel immediately after the acquisition,
                               which resulted in a loss of business with certain
                               federal and

                                        3
<PAGE>
                               corporate accounts, and also suffered the effects
                               of erosion in margins brought on by price
                               pressure in the generic drug industry. We have
                               taken actions intended to improve Superior's
                               performance. In the past six months, Superior has
                               hired and trained additional sales staff,
                               upgraded its systems and instituted controls to
                               improve margins. Superior is also aggressively
                               bidding on federal and state contracts and has
                               won supply agreements with the governments of the
                               states of Florida, Ohio, Louisiana and Texas. We
                               can give no assurance, however, that these
                               actions will improve Superior's performance in
                               the near future or at all.

                 Generic
                 Distributors: In March 1998, we acquired Generic Distributors
                               Limited Partnership, a distributor of generic
                               drugs based in Monroe, Louisiana. Generic
                               Distributors' customer base consists primarily
                               of independent pharmacies in the states of
                               Louisiana, Texas, Arkansas, Alabama and
                               Mississippi. We believe that Generic Distributors
                               complements Superior by providing next-day
                               delivery service to the southern and southeastern
                               United States. We believe that Generic
                               Distributors has the potential to grow its
                               business through supply opportunities with
                               institutional, hospital and nursing home
                               pharmacies. We can give no assurance that such
                               opportunities will arise, though, or that we will
                               be able to exploit any such opportunities
                               profitably.

OUR ADDRESS:       Our corporate headquarters is at 1000 Winter Street, Suite
                   2700, Waltham, MA 02154. The telephone number at our
                   corporate office is (781) 890-0021, and the facsimile number
                   is (781) 890-0118.

SPECIAL
CONSIDERATIONS
AND RISK FACTORS:  We experienced a sharp decline in our stock price and market
                   value in 1997 and 1998. In the section of this prospectus
                   entitled "Risk Factors," beginning on page 5, we have
                   described several matters which we believe are significant
                   and which you should consider very carefully before you
                   decide to invest in the common stock. There are two specific
                   factors to which we want to draw your attention:

                   o      our independent auditors, in their opinion on our
                          financial statements as of December 31, 1998 and for
                          the year then ended, expressed substantial doubt as to
                          our ability to continue as a going concern; and

                   o      we need significant additional financing to continue
                          operations.


                                  THE OFFERING

COMMON STOCK OFFERED:     All of the 7,237,529 shares offered by this prospectus
                          are being sold by the selling stockholders. Certain of
                          the selling stockholders hold shares of convertible
                          preferred stock and warrants to purchase common stock
                          which they acquired in private investment transactions
                          in May 1999 and June 1999.

USE OF PROCEEDS:          We will not receive any of the proceeds from sales of
                          shares by the selling stockholders.

                                        4
<PAGE>
                                  RISK FACTORS

     Before you invest in our common stock, you should be aware that there are
various risks, including those described below. We have set forth below the
material risk factors necessary to make an informed investment decision. You
should carefully consider these risk factors, together with all of the other
information included in this prospectus, including information incorporated by
reference, before you decide whether to purchase shares of our common stock.

     Some of the information in this prospectus contains forward-looking
statements that involve substantial risks and uncertainties. You can identify
these statements by forward-looking words such as "may," "will," "expect,"
"anticipate," "believe," "estimate," "continue" and similar words. You should
read statements that contain these words carefully because they: (1) discuss our
future expectations; (2) contain projections of our future operating results or
financial condition; or (3) state other "forward-looking" information. We
believe it is important to communicate our expectations to our investors. There
may be events in the future, however, that we are not accurately able to predict
or over which we have no control. The risk factors listed in this section, as
well as any cautionary language in this prospectus, provide examples of risks,
uncertainties and events that may cause our actual results to be materially
worse than the expectations we describe in our forward-looking statements.
Before you invest in our common stock, you should be aware that the occurrence
of any of the events described in these risk factors and elsewhere in this
prospectus could materially and adversely affect our business. If that happens,
the trading price of our common stock could decline and you could lose all or
part of your investment.

     IF WE CONTINUE TO INCUR LOSSES, THEN THE VALUE OF OUR COMMON STOCK WILL
     LIKELY DECLINE
     We have incurred operating losses in every operating period since our
inception. We had an accumulated deficit of $53,652,377 as of June 30, 1999. We
incurred a net loss of $3,498,824 in the six months ended June 30, 1999. We
anticipate future losses, and we can give no assurance that we will ever
generate substantial revenues from our business, or achieve profitability. If we
continue to incur operating losses, then the value of our common stock will
likely decline and you could lose your investment.

     Our losses have resulted principally from expenses we incurred in research
and development activities, and from general and administrative costs associated
with our development efforts. In addition, our Able subsidiary has incurred
operating losses, primarily because its revenues have not equaled its expenses.
To continue development of our current and proposed products, we will need to
expend substantial additional resources to conduct further product development
and to establish and expand our manufacturing, sales, marketing, regulatory and
administrative capabilities. Therefore, we expect to incur substantial operating
losses over the next several years as we expand our product programs and
commence marketing efforts.

     IF WE CANNOT RAISE SIGNIFICANT ADDITIONAL FUNDS, THEN WE WILL LIKELY FACE
     BANKRUPTCY AND YOU COULD LOSE YOUR INVESTMENT

     Our history of operating losses raises substantial doubt about our ability
to continue operations. If we are unable to secure significant additional
financing or to renegotiate our agreements with our existing creditors, we may
be obliged to seek protection from our creditors by declaring bankruptcy. If
that happens, you could lose your entire investment. Our independent auditors
issued an opinion on our financial statements as of December 31, 1998 and for
the year then ended which included an explanatory paragraph expressing
substantial doubt about our ability to continue as a going concern. The reasons
cited by the independent auditors include the following:

     o   we have incurred recurring losses from operations resulting in a
         stockholders' deficit and a working capital deficiency at December 31,
         1998;
                                        5
<PAGE>
     o   we have defaulted on conditions placed upon us by our banks and other
         lenders; and

     o   our ability to use cash generated by our subsidiaries is restricted
         under the terms of the subsidiaries' loan agreements.

     OUR COMPETITORS COULD PREVENT US FROM ACHIEVING OUR BUSINESS GOALS

     In order to succeed in the generic drug business, we need to achieve a
significant share of the market for each generic drug we market. The generic
drug manufacturing and distribution business is highly competitive. We compete
with several companies that are better capitalized than we are and that have
financial and human resources significantly greater than ours. Because we
manufacture generic drugs, our products by their very nature are chemically and
biologically equivalent to the products of our larger and profitable
competitors. Also, we believe that, as a rule, the first one or two companies to
bring a generic alternative to the market will capture the highest market share
for that product. These larger companies, with their greater resources, could
bring products to market before us, and could capture a significant share of the
market at our expense.

     IF THE BOSTON STOCK EXCHANGE DELISTS OUR COMMON STOCK, WE WILL HAVE GREATER
     DIFFICULTY RAISING THE CAPITAL WE NEED TO CONTINUE OPERATIONS

     Our common stock has been delisted from the Nasdaq Stock Market and is
listed on the Boston Stock Exchange. The common stock is also quoted on the OTC
Bulletin Board. If the common stock was delisted by the Boston Stock Exchange,
then public perception of the value of the common stock could be materially
adversely affected. You could lose your investment and we could face greater
difficulty raising capital necessary for our continued operations.

     We received a notice from the Boston Stock Exchange on April 12, 1999
informing us that our common stock did not meet the requirements for continued
listing. The Boston Stock Exchange requires a minimum of $500,000 in
stockholders' equity for continued listing. As of March 31, 1999, we had a
stockholders' deficit of approximately $4,024,000, a shortfall of approximately
$4,524,000, and therefore we did not meet the listing requirements. We responded
to the Boston Stock Exchange, explaining our plan for regaining compliance with
this requirement by June 30, 1999. On July 8, 1999, we advised the Boston Stock
Exchange that we expected our stockholders' equity as of June 30, 1999 would
exceed $500,000. Stockholders' equity as of June 30, 1999 was approximately
$848,000. Therefore, as of that date we met the requirement and so our common
stock remains listed on the Boston Stock Exchange. Our common stock could face
delisting action again, however, if we do not maintain the minimum stockholders
equity or other listing requirements.

     IF OUR COMMON STOCK BECOMES SUBJECT TO PENNY STOCK RULES, YOU MAY HAVE
     GREATER DIFFICULTY SELLING YOUR SHARES

     The Securities Enforcement and Penny Stock Reform Act of 1990 applies to
stock characterized as "penny stocks," and requires additional disclosure
relating to the market for penny stocks in connection with trades in any stock
defined as a penny stock. The Securities and Exchange Commission has adopted
regulations that generally define a penny stock to be any equity security that
has a market price of less than $5.00 per share, subject to certain exceptions.
The exceptions include exchange-listed equity securities and any equity security
issued by an issuer that has

     o   net tangible assets of at least $2,000,000, if the issuer has been in
         continuous operation for at least three years;

     o   net tangible assets of at least $5,000,000, if the issuer has been in
         continuous operation for less than three years; or

                                        6
<PAGE>
     o   average annual revenue of at least $6,000,000 for the last three years.

     Unless an exception is available, the regulations require the delivery,
prior to any transaction involving a penny stock, of a disclosure schedule
explaining the penny stock market and the associated risks.

     If our common stock is delisted from the Boston Stock Exchange, then
trading in the common stock will be covered by Rules 15g-1 through 15g-6 and
15g-9 promulgated under the Securities Exchange Act. Under those rules,
broker-dealers who recommend such securities to persons other than their
established customers and institutional accredited investors must make a special
written suitability determination for the purchaser and must have received the
purchaser's written agreement to a transaction prior to sale. These regulations
would likely limit the ability of broker-dealers to trade in our common stock
and thus would make it more difficult for purchasers of common stock to sell
their securities in the secondary market. The market liquidity for the common
stock could be severely affected.

     WE ARE OBLIGATED TO ISSUE A LARGE NUMBER OF SHARES OF COMMON STOCK AT
     PRICES BELOW THE MARKET PRICE, WHICH COULD ADVERSELY AFFECT THE VALUE
     OF THE COMMON STOCK

     We are obligated to issue a large number of shares of common stock at
prices lower than market value. Therefore, the common stock could lose value if
a large number of shares are issued into the market. At June 30, 1999,
56,038,796 shares of common stock were issued and outstanding. We have issued a
large number of securities, such as options, warrants, convertible preferred
stock and convertible notes, that are convertible by their holders into shares
of common stock. As of June 30, 1999, we were obligated to issue up to
approximately 8,643,592 shares of common stock upon the conversion or exercise
of convertible securities. We have also reserved 8,744,774 shares of common
stock for issuance pursuant to options granted to our employees, officers,
directors and consultants. The holders of these convertible securities likely
would only exercise their rights to acquire common stock at times when the
exercise price is lower than the price at which they could buy the common stock
on the open market. Because we would likely receive less than current market
price for any shares of common stock issued upon exercise of options and
warrants, the exercise of a large number of these convertible securities could
reduce the per-share market price of common stock held by existing investors.
Also, the exercise of a large number of convertible securities could limit our
ability to obtain additional equity capital by selling common stock. In all
likelihood, we would be able to sell shares of common stock elsewhere on more
favorable terms at the time the holders of convertible securities chose to
exercise their rights.

     THE VALUE OF THE COMMON STOCK FLUCTUATES WIDELY AND YOU COULD LOSE MONEY ON
     YOUR INVESTMENT IN OUR STOCK
     The price of our common stock has fluctuated widely in the past, and it is
likely that it will continue to do so in the future. The market price of our
common stock could fluctuate substantially based on a variety of factors,
including:

     o   quarterly fluctuations in our operating results;

     o   announcements of new products by us or our competitors;

     o   key personnel losses;

     o   sales of common stock; and

     o   developments or announcements with respect to industry standards,
         patents or proprietary rights.

     The market price of our common stock has fluctuated between $70.00 and $.10
from January 1, 1993 to
                                        7
<PAGE>

December 31, 1998. Over the past twelve months, the common stock has fluctuated
between approximately $.89 and approximately $.05, and was approximately $.50 on
September 2, 1999. These broad market fluctuations could adversely affect the
market price of our common stock, in that at the current price, any fluctuation
in the dollar price per share could constitute a significant percentage decrease
in the value of your investment. Also, when the market price of a stock has been
volatile, holders of that stock have often instituted securities class action
litigation against the company that issued the stock. If any of our stockholders
brought such a lawsuit against us, we could incur substantial costs defending
the lawsuit and we would have to divert management time and attention away from
operations. A lawsuit based on the volatility of the stock price, in whole or in
part, could seriously harm our business and your investment.

     WE COULD FACE A SIGNIFICANT INTERRUPTION IN OUR OPERATIONS CAUSED BY YEAR
     2000 ISSUES

     We have not completed an exhaustive analysis of potential Year 2000 issues,
and consequently we cannot rule out the chance that we could face serious
operational problems as a result of the Year 2000 year change.

     Many software products and computer systems are coded to accept only
two-digit entries in the date code field. These date code fields will need to
accept four digit entries to distinguish 21st century dates from 20th century
dates. This ability is commonly referred to as being Year 2000 compliant. We
have not conducted a comprehensive Year 2000 compliance review of the computer
software we use, or that is used by our vendors and suppliers use. If the
software and computer systems we use are not Year 2000 compliant, we could face
system failures or miscalculations causing disruptions of operations, including
a temporary inability to process transactions, send invoices or engage in
similar normal business activities. If the systems maintained by our vendors and
suppliers are not Year 2000 compliant, we could incur significant unanticipated
expenses to remedy any problems or to replace affected vendors and suppliers.
Because we have not completed a review of potential Year 2000 issues, we cannot
rule out the possibility that a significant problem might result from Year 2000
issues. In the worst case, we might be unable to obtain necessary raw materials
or process orders for our inventory, and we could be forced to curtail or
suspend our operations.

     WE MAY FACE PRODUCT LIABILITY FOR WHICH WE ARE NOT ADEQUATELY INSURED

     The testing, marketing and sale of drug products for human use is
inherently risky. Liability might result from claims made directly by consumers
or by pharmaceutical companies or others selling our products. Superior, Generic
Distributors and Able presently carry product liability insurance in amounts
that we believe to be adequate, but we can give no assurance that such insurance
will remain available at a reasonable cost or that any insurance policy would
offer coverage sufficient to meet any liability arising as a result of a claim.
We can give no assurance that we will be able to obtain or maintain adequate
insurance on reasonable terms or that, if obtained, such insurance will be
sufficient to protect us against such potential liability or at a reasonable
cost. The obligation to pay any product liability claim or a recall of a product
could have a material adverse affect on our business, financial condition and
future prospects.

     INTENSE REGULATION BY GOVERNMENT AGENCIES MAY DELAY OUR EFFORTS TO
     COMMERCIALIZE OUR PROPOSED DRUG PRODUCTS

     Before we can market any generic drug, we must first obtain FDA approval of
the proposed drug and of the active drug raw materials that we use. In many
instances, our approvals cover only one source of raw materials. If raw
materials from a specified supplier were to become unavailable, we would be
required to file a supplement to our Abbreviated New Drug Application to use a
different manufacturer and revalidate the manufacturing process using a new
supplier's materials. This could cause a delay of several months in the
manufacture of the drug involved and the consequent loss of potential revenue
and market share. For example, for a period of time we were unable to acquire
the active drug for our clorazapate dipotassium product, and so we had to
discontinue production of the product. The active drug ingredient has since
become available again and we have resumed manufacturing the product.


                                        8
<PAGE>

                                 USE OF PROCEEDS

     All of the shares of common stock offered by this prospectus are being
offered by the selling stockholders. We received proceeds from the sale of the
notes and shares of convertible preferred stock that were converted, or are
convertible, into the shares of common stock offered in this prospectus. This
money was used for working capital and general corporate purposes. We will not
receive any additional proceeds from the sale of shares by the selling
stockholders. For information about the selling stockholders, see "Selling
Stockholders."

                                 DIVIDEND POLICY

     We have never declared or paid cash dividends on our common stock. We
currently intend to retain earnings, if any, to fund our business, and therefore
we do not anticipate paying cash dividends in the foreseeable future. If we ever
earn income on which we would be entitled to declare or pay dividends, we expect
that our Board of Directors would decide whether to pay dividends after taking
into account various factors including our financial condition, results of
operations, current and anticipated cash needs, and plans for expansion.


                              SELLING STOCKHOLDERS

     All of the 7,237,529 shares offered by this prospectus are being registered
for sale for the accounts of selling stockholders. As noted in the following
table, except for one selling stockholder, the selling stockholders have
obtained or will obtain the common stock offered under this prospectus by
converting or exercising certain convertible securities of DynaGen that they now
hold. These selling stockholders hold shares of Series I Preferred Stock and
warrants to purchase common stock, which we issued to them in private investment
transactions in May 1999 and June 1999.

     The table below includes, in the total number of shares offered, 6,887,152
shares of common stock that have been issued or are issuable upon conversion of
shares of Series I Preferred Stock. Pursuant to the terms of the Series I
Preferred Stock, the selling stockholders may convert shares of Series I
Preferred Stock to acquire shares of common stock at a conversion price equal to
80% of the market price of the common stock for three of the five days preceding
the conversion.

     The table below also includes 200,377 shares of common stock issuable upon
exercise of warrants issued to the selling stockholders. The warrants are
exercisable to purchase common stock at an average exercise price of $.75 per
share. If all of the warrants were exercised, then we would receive proceeds of
approximately $150,000. However, we cannot predict whether, or how many of, the
warrants will be exercised.

     The remaining 150,000 shares of common stock offered by this prospectus are
issued and outstanding, and held by a selling stockholder.

     We will not receive any portion of the proceeds from the sale of shares of
common stock by the selling stockholders.

     Based on the information supplied to DynaGen by each selling stockholder,
the following table sets forth certain information regarding the approximate
number of shares owned by each selling stockholder as of August 25, 1999, and as
adjusted to reflect the sale by the selling stockholders of the shares of common
stock offered by this prospectus. No selling stockholder has held any office or
maintained any material relationship with DynaGen, or any of our predecessors or
affiliates, over the past three years.

                                       9
<PAGE>
<TABLE>
<CAPTION>
                                                          SHARES                                 SHARES
                                                    BENEFICIALLY OWNED                      BENEFICIALLY OWNED
                                                   PRIOR TO OFFERING(1)        NUMBER      AFTER OFFERING(1)(2)
                                                 -------------------------   OF SHARES     ---------------------
NAME AND ADDRESS                                    NUMBER      PERCENT(3)   OFFERED(4)     NUMBER     PERCENT
- --------------------                             -------------  ----------  -------------  ---------  ----------
<S>                                              <C>            <C>         <C>            <C>        <C>

The Endeavour Capital Fund, S.A.(5)
c/o Endeavour Management Inc. 14/14
Divrei Chaim St., Jerusalem, Israel 94479 ........  2,965,813     4.9%         2,385,813      --          --

Sovereign Partners, L.P.
c/o Southridge Capital Management LLC
90 Grove Street
Ridgefield, CT 06877(6) ..........................  1,656,143     2.8%         1,656,143      --          --

Dominion Capital Fund Limited
c/o Citco Fund Services (Bahamas) Limited
Nassau, Bahama(7) ................................  1,869,461     3.1%         1,869,461      --          --

Dominion Investment Fund LLC
c/o Citco Fund Services (Bahamas) Limited
Nassau, Bahama(7) ................................    232,983       *            232,983      --          --

Canadian Advantage Fund Limited Partnership
365 Bay Street
Toronto, Canada 75H 2V2(8) .......................    465,965       *            465,965      --          --

Gross Foundation, Inc.
1661-49th Street
Brooklyn, NY(9) ..................................    477,164       *            477,164      --          --

Venture Partners Capital LLC
c/o 50 Federal Street
Boston, MA 02109(10) .............................    150,000       *            150,000      0           --
- ----------------
</TABLE>

 *   Less than 1.0%.

(1)  Beneficial ownership is determined in accordance with the rules of the
     Securities and Exchange Commission and generally includes voting or
     investment power with respect to securities. Except as indicated, each
     person possesses sole voting and investment power with respect to all of
     the shares of common stock owned by such person, subject to community
     property laws where applicable. In computing the number of shares
     beneficially owned by a person and the percentage ownership of that person,
     shares of common stock subject to options and convertible securities held
     by that person that are currently exercisable, or become exercisable within
     60 days of the date of this prospectus are deemed outstanding. Such shares,
     however, are not deemed outstanding for the purpose of computing the
     percentage ownership of any other person. The information as to each person
     has been furnished by such person.
(2)  Assumes that all shares of common stock offered in this prospectus will be
     sold.
(3)  Based on 57,162,136 shares of common stock issued and outstanding as of
     September 1, 1999.
(4)  With respect to all of the selling stockholders other than Venture Partners
     Capital LLC, the shares offered represent shares of common stock issuable
     upon the exercise of common stock purchase warrants and shares of Series I
     Preferred Stock, $0.01 par value per share, sold to the selling
     stockholders in private transactions in May 1999 and June 1999,
     respectively.

(5)  Mr. Shmuli Margulies, director of Endeavour Capital Fund S.A., is the
     individual who has voting and investment decision authority over this
     investment.
(6)  Messrs. Stephen Hicks and Daniel Pickett are the individuals who have
     voting and investment decision authority over this investment.

                                       10
<PAGE>

(7)  Mr. David Sims is the individual who has voting and investment decision
     authority over this investment.
(8)  Messrs. Mark Valentine and Ian McKinnon are the individuals who have voting
     and investment decision authority over this investment.
(9)  Mr. Chaim Gross is the individual who has voting and investment decision
     authority over this investment.

(10) Mr. Andrew Clapp, Managing Director of Venture Partners, is the individual
     who has voting and investment decision authority over this investment.


                              PLAN OF DISTRIBUTION

     The shares offered by this prospectus may be sold from time to time by
selling stockholders, who consist of the persons named under "Selling
Stockholders" above and those persons' pledgees, donees, transferees or other
successors in interest. The selling stockholders may sell the shares on the OTC
Bulletin Board, on the Boston Stock Exchange or otherwise, at market prices or
at negotiated prices. They may sell shares by one or a combination of the
following:

     o   a block trade in which a broker or dealer so engaged will attempt to
         sell the shares as agent, but may position and resell a portion of the
         block as principal to facilitate the transaction;

     o   purchases by a broker or dealer as principal and resale by the broker
         or dealer for its account pursuant to this prospectus;

     o   ordinary brokerage transactions and transactions in which a broker
         solicits purchasers;

     o   an exchange distribution in accordance with the rules of such exchange;

     o   privately negotiated transactions;

     o   short sales;

     o   if such a sale qualifies, in accordance with Rule 144 promulgated under
         the Securities Act rather than pursuant to this prospectus; and

     o   any other method permitted pursuant to applicable law.


     In making sales, brokers or dealers engaged by the selling stockholders may
arrange for other brokers or dealers to participate. Brokers or dealers will
receive commissions or discounts from selling stockholders in amounts to be
negotiated prior to the sale. The selling stockholders and any broker-dealers
that participate in the distribution may be deemed to be "underwriters" within
the meaning of Section 2(11) of the Securities Act of 1933, and any proceeds or
commissions received by them, and any profits on the resale of shares sold by
broker-dealers, may be deemed to be underwriting discounts and commissions.

     If any selling stockholder notifies us that a material arrangement has been
entered into with a broker-dealer for the sale of shares through a block trade,
special offering, exchange distribution or secondary distribution or a purchase
by a broker or dealer, we will file a prospectus supplement, if required
pursuant to Rule 424(c) under the Securities Act of 1933, setting forth:

     o   the name of each of the participating broker-dealers,

     o   the number of shares involved,

     o   the price at which the shares were sold,

                                       11
<PAGE>

     o   the commissions paid or discounts or concessions allowed to the
         broker-dealers, where applicable,

     o   a statement to the effect that the broker-dealers did not conduct any
         investigation to verify the information set out or incorporated by
         reference in this prospectus, and

     o   any other facts material to the transaction.

     We are paying the expenses incurred in connection with preparing and filing
this prospectus and the registration statement to which it relates, other than
selling commissions.

     In addition, in the event the selling stockholders sell short shares of
common stock, this prospectus may be delivered in connection with such short
sales and the shares offered by this prospectus may be used to cover such short
sales. To the extent, if any, that the selling stockholders may be considered
"underwriters" within the meaning of the Securities Act, the sale of the shares
by them shall be covered by this prospectus.


                                  LEGAL MATTERS

     Foley, Hoag & Eliot LLP, Boston, Massachusetts, has advised us with respect
to the validity of the shares of common stock offered by this prospectus.


                                     EXPERTS

     The financial statements for each of the two fiscal years ended December
31, 1998 and 1997, incorporated by reference in this prospectus and in the
registration statement of which this prospectus is part, have been audited by
Wolf & Company, P.C., independent public accountants, as indicated in their
report with respect to such financial statements. The incorporation by reference
in this prospectus and in the registration statement of which it is part, is in
reliance upon such reports given upon the authority of Wolf & Company as experts
in accounting and auditing.

                          DISCLOSURE OF SEC POSITION ON
                 INDEMNIFICATION FOR SECURITIES ACT LIABILITIES

     DynaGen's Restated Certificate of Incorporation and By-Laws provide that we
will indemnify our directors and officers, to the fullest extent permitted under
Delaware law, including in circumstances in which indemnification is otherwise
discretionary under Delaware law.

     Insofar as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers or controlling persons of DynaGen,
pursuant to the foregoing provisions, or otherwise, we have been advised that,
in the opinion of the SEC, such indemnification is against public policy as
expressed in the Securities Act, and is, therefore, unenforceable.


                       WHERE YOU CAN FIND MORE INFORMATION

     We file annual reports, quarterly reports, current reports, proxy
statements and other information with the Securities and Exchange Commission.
You may read and copy any of our SEC filings at the SEC's public reference room
at 450 Fifth Street, N.W., Washington D.C. 20549. You may call the SEC at
1-800-SEC-0330 for further information about the public reference room. Our SEC
filings also are available to the public on the SEC's website at
http://www.sec.gov.

     The SEC allows us to "incorporate by reference" information from certain of
our other SEC filings. This means that we can disclose information to you by
referring you to those other filings, and the information incorporated by
reference is considered to be part of this prospectus. In addition, certain
information that we file with the SEC after the date of this prospectus will
automatically update, and in some cases supersede, the information contained or
otherwise incorporated by reference in this prospectus. We are incorporating by
reference the information contained in the following SEC filings (File No.
1-11352):

                                       12
<PAGE>
     o   Our Annual Report on Form 10-KSB for the year ended December 31, 1998;

     o   Our Quarterly Report on Form 10-QSB for the three months ended March
         31, 1999;

     o   Our Quarterly Report on Form 10-QSB for the three months ended June 30,
         1999;

     o   The "Description of Securities" contained in our Registration Statement
         on Form 8-A filed August 19, 1992 together with all amendments and
         reports filed for the purpose of updating that description;

     o   All other documents we filed pursuant to Section 13(a) or 15(d) of the
         Exchange Act since the end of the fiscal year covered by the Annual
         Report referred to above; and

     o   any filings we make with the SEC under Section 13(a), 13(c), 14 or
         15(d) of the Securities Exchange Act of 1934 (i) subsequent to the
         initial filing of this prospectus and prior to the date it is declared
         effective and (ii) subsequent to the date of this prospectus and prior
         to the termination of this offering. Information in these filings will
         be incorporated as of the filing date.

     You may request copies of these filings, at no cost, by writing or
telephoning us as follows:

                       Investor Relations
                       DynaGen, Inc.
                       1000 Winter Street, Suite 2700
                       Waltham, Massachusetts 02451
                       Telephone:  (781) 890-0021

     This prospectus is part of a registration statement on Form S-3 we filed
with the SEC under the Securities Act of 1933. This prospectus does not contain
all of the information contained in the registration statement. For further
information about us and our common stock, you should read the registration
statement and the exhibits filed with the registration statement.

                                       13
<PAGE>
                                     PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 14.  OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

     The following table sets forth the various expenses to be paid by the
Registrant in connection with the issuance and distribution of the shares of
common stock being registered. All amounts shown are estimates, except for the
Securities and Exchange Commission registration fee. The Registrant will pay all
expenses in connection with the distribution of the shares of common stock being
sold by the Selling Stockholders (including fees and expenses of counsel for the
Registrant), except for the underwriting discount and for legal fees of any
counsel selected by any particular Selling Stockholder.


     Securities and Exchange Commission registration fee .........  $    985.90
     Boston Stock Exchange listing additional shares fee .........     5,000.00
     Accounting fees and expenses.................................     2,000.00
     Legal fees and expenses .....................................    12,000.00
     Blue sky fees and expenses, including legal fees ............     1,000.00
     Printing, EDGAR formatting and mailing expenses .............     2,000.00
     Miscellaneous ...............................................     2,014.10
                                                                    -----------
             Total ...............................................  $ 25,000.00
                                                                    ===========


ITEM 15. INDEMNIFICATION OF DIRECTORS AND OFFICERS

         (A) The Company is a Delaware corporation. Section 145 of the Delaware
General Corporation Law, as amended, provides in regard to indemnification of
directors and officers as follows:

         "(a) A corporation may indemnify any person who was or is a party or is
threatened to be made a party to any threatened, pending or completed action,
suit or proceeding, whether civil, criminal, administrative or investigative
(other than an action by or in the right of the corporation) by reason of the
fact that he is or was a director, officer, employee or agent of the
corporation, or is or was serving at the request of the corporation as a
director, officer, employee or agent of another corporation, partnership, joint
venture, trust or other enterprise, against expenses (including attorneys'
fees), judgments, fines and amounts paid in settlement actually and reasonably
incurred by him in connection with such action, suit or proceeding if he acted
in good faith and in a manner he reasonably believed to be in or not opposed to
the best interests of the corporation, and, with respect to any criminal action
or proceeding, had no reasonable cause to believe his conduct was unlawful. The
termination of any action, suit or proceeding by judgment, order, settlement,
conviction, or upon a plea of nolo contendere or its equivalent, shall not, of
itself, create a presumption that the person did not act in good faith and in a
manner which he reasonably believed to be in or not opposed to the best
interests of the corporation, and, with respect to any criminal action or
proceeding, had reasonable cause to believe that his conduct was unlawful.

         (b) A corporation may indemnify any person who was or is a party or is
threatened to be made a party to any threatened, pending or completed action or
suit by or in the right of the corporation to procure a judgment in its favor by
reason of the fact that he is or was a director, officer, employee or agent of
the corporation, or is or was serving at the request of the corporation as a
director, officer, employee or agent of another corporation, partnership, joint
venture, trust or other enterprise against expenses (including attorneys' fees)
actually and reasonably incurred by him in connection with the defense or
settlement of such action or suit if he acted in good faith and in a manner he
reasonably believed to be in or not opposed to the best interests of the
corporation and except that no indemnification shall be made in respect of any
claim, issue or matter as to which such person shall have been adjudged to be
liable to the corporation unless and only to the extent that the Court of
Chancery or the court in which such action or suit was brought shall determine
upon application that, despite the adjudication of liability but in view of all
the circumstances of the case, such person is fairly

                                      II-1
<PAGE>

and reasonably entitled to indemnity for such expenses which the Court of
Chancery or such other court shall deem proper.

         (c) To the extent that a present or former director or officer of a
corporation has been successful on the merits or otherwise in defense of any
action, suit or proceeding referred to in subsections (a) and (b) of this
section, or in defense of any claim, issue or matter therein, such person shall
be indemnified against expenses (including attorneys' fees) actually and
reasonably incurred by such person in connection therewith.

         (d) Any indemnification under subsections (a) and (b) of this section
(unless ordered by a court) shall be made by the corporation only as authorized
in the specific case upon a determination that indemnification of the present or
former director, officer, employee or agent is proper in the circumstances
because he has met the applicable standard of conduct set forth in subsections
(a) and (b) of this section. Such determination shall be made, with respect to a
person who is a director or officer at the time of such determination, (1) by
the board of directors by a majority vote of a quorum consisting of directors
who were not parties to such action, suit or proceeding, or (2) by a committee
of such directors designated by majority vote of such directors, even though
less than a quorum, or (3) if such a quorum is not obtainable, or, even if
obtainable a quorum of disinterested directors so directs, by independent legal
counsel in a written opinion, or (3) by the stockholders.

         (e) Expenses (included attorneys' fees) incurred by an officer or
director in defending any civil, criminal, administrative or investigative
action suit or proceeding may be paid by the corporation in advance of the final
disposition of such action, suit or proceeding upon receipt of an undertaking by
or on behalf of such director or officer to repay such amount if it shall
ultimately be determined that such person is not entitled to be indemnified by
the corporation as authorized in this section. Such expenses (including
attorneys' fees) incurred by former director or officers or employees and agents
may be so paid upon such terms and conditions, if any, as the corporation deems
appropriate.

         (f) The indemnification and advancement of expenses provided by, or
granted pursuant to, the other subsections of this section shall not be deemed
exclusive of any other rights to which those seeking indemnification or
advancement of expenses may be entitled under any bylaw, agreement, vote of
stockholders or disinterested directors or otherwise, both as to action in such
person's official capacity and as to action in another capacity while holding
such office.

         (g) A corporation shall have power to purchase and maintain insurance
on behalf of any person who is or was a director, officer, employee or agent of
the corporation, or is or was serving at the request of the corporation as a
director, officer, employee or agent of another corporation, partnership, joint
venture, trust or other enterprise against any liability asserted against such
person and incurred by such person in any such capacity, or arising out of such
person's status as such, whether or not the corporation would have the power to
indemnify such person against such liability under this section.

         (h) For purposes of this section, references to "the corporation" shall
include, in addition to the resulting corporation, any constituent corporation
(including any constituent of a constituent) absorbed in a consolidation or
merger which, if its separate existence had continued, would have had power and
authority to indemnify its directors, officers, and employees or agents so that
any person who was a director, officer, employee or agent of such constituent
corporation, or is or was serving at the request of such constituent corporation
as a director, officer, employee or agent of another corporation, partnership,
joint venture, trust or other enterprise, shall stand in the same position under
this section with respect to the resulting or surviving corporation as such
person would have with respect to such constituent corporation if its separate
existence had continued.

         (i) For purposes of this section, references to "other enterprises"
shall include employee benefit plans; references to "fines" shall include any
excise taxes assessed on a person with respect to any employee benefit plan; and
references to "serving at the request of the corporation" shall include any
service as a director,
                                      II-2
<PAGE>

officer, employee or agent of the corporation which imposes duties on, or
involves services by, such director, officer, employee, or agent with respect to
an employee benefit plan, its participants or beneficiaries; and a person who
acted in good faith and in a manner such person reasonably believed to be in the
interest of the participants and beneficiaries of an employee benefit plan shall
be deemed to have acted in a manner "not opposed to the best interests of the
corporation" as referred to in this section.

         (j) The indemnification and advancement of expenses provided by, or
granted pursuant to, this section shall, unless otherwise provided when
authorized or ratified, continue as to a person who has ceased to be a director,
officer, employee or agent and shall inure to the benefit of the heirs,
executors and administrators of such a person.

         (k) The Court of Chancery is hereby vested with exclusive jurisdiction
to hear and determine all actions for advancement of expenses or indemnification
brought under this section or under any bylaw, agreement, vote of stockholders
or disinterested directors, or otherwise. The Court of Chancery may summarily
determine a corporation's obligation to advance expenses."

         (B) Article 9 of the Company's Certificate of Incorporation contains
the following provision relating to the indemnification of directors and
officers:

         "To the maximum extent permitted by Section 102(b)(7) of the General
Corporation Law of Delaware, a director of this Corporation shall not be
personally liable to the Corporation or its stockholders for monetary damages
for breach of fiduciary duty as a director, except for liability (i) for any
breach of the director's duty of loyalty to the Corporation or its stockholders,
(ii) for acts or omissions not in good faith or which involve intentional
misconduct or a knowing violation of law, (iii) under Section 174 of the
Delaware General Corporation Law, or (iv) for any transaction from which the
director derived an improper personal benefit."

         (C) Article VII of the Company's By-laws contains the following
provisions relating to indemnification of officers and directors:

         "Reference is made to Section 145 and any other relevant provisions of
the General Corporation Law of the State of Delaware. Particular reference is
made to the class of persons, hereinafter called "Indemnitees," who may be
indemnified by a Delaware corporation pursuant to the provisions of such Section
145, namely, any person or the heirs, executors, or administrators of such
person, who was or is a party or is threatened to be made a party to any
threatened, pending or completed action, suit, or proceeding, whether civil,
criminal, administrative, or investigative, by reason of the fact that such
person is or was a director, officer, employee, or agent of such corporation or
is or was serving at the request of such corporation as a director, officer,
employee, or agent of such corporation or is or was serving at the request of
such corporation as a director, officer, employee or agent of another
corporation, partnership, joint venture, trust, or other enterprise. The
Corporation shall, and is hereby obligated to, indemnify the Indemnitees, and
each of them in each and every situation where the Corporation is obligated to
make such indemnification pursuant to the aforesaid statutory provisions. The
Corporation shall indemnify the Indemnitees, and each of them, in each and every
situation where, under the aforesaid statutory provisions, the Corporation is
not obligated, but is nevertheless permitted or empowered, to make such
indemnification, it being understood that, before making such indemnification
with respect to any situation covered under this sentence, (i) the Corporation
shall promptly make or cause to be made, by any of the methods referred to in
Subsection (d) of such Section 145, a determination as to whether each
Indemnitee acted in good faith and in a manner he reasonably believed to be in,
or not opposed to, the best interests of the Corporation, and, in the case of
any criminal action or proceeding, had no reasonable cause to believe that his
conduct was unlawful, and (ii) that no such indemnification shall be made unless
it is determined that such Indemnitee acted in good faith and in a manner he
reasonably believed to be in, or not opposed to, the best interests of the
Corporation, and, in the case of any criminal action or proceeding, had no
reasonable cause to believe that his conduct was unlawful."

                                      II-3
<PAGE>
         The effect of these provisions would be to permit indemnification by
the Company of for, among other liabilities, liabilities arising under the
Securities Act of 1933 (the "Securities Act").

ITEM 16. EXHIBITS

EXHIBIT NO.     NAME OF EXHIBIT
- -----------
    4.1    Specimen certificate for common stock filed as Exhibit 4a to the
           Company's Registration Statement on Form S-1, No. 33-31836-B and
           incorporated by reference)

    4.2    Securities Purchase Agreement dated May 13, 1999 by and among the
           Company and the several purchasers named therein (previously filed)

    4.3    Form of Debenture issued in connection with the May 13, 1999
           Securities Purchase Agreement (previously filed)

    4.4    Form of Common Stock Purchase Warrant issued in connection with the
           May 13, 1999 Securities Purchase Agreement (previously filed)

    4.5    Registration Rights Agreement dated May 13, 1999 (previously filed)

    4.6    Form of Exchange Agreement dated June 29, 1999 (previously filed)

    4.7    Certificate of Designations, Preferences, and Rights of Series I
           Preferred Stock (previously filed) 5.1 Opinion of Foley, Hoag & Eliot
           LLP (previously filed)

   23.1    Consent of Wolf & Company, P.C.

   23.2    Consent of Foley, Hoag & Eliot LLP (previously filed) 24.1 Powers
           of Attorney (previously filed)

- --------------

ITEM 17. UNDERTAKINGS

(a)  The undersigned Registrant hereby undertakes:

     (1) To file, during any period in which offers or sales are being made, a
         post-effective amendment to this Registration Statement;

         (i)   To include any prospectus required to Section 10(a)(3) of the
               Securities Act of 1933;

         (ii)  To reflect in the prospectus any facts or events arising after
               the effective date of the Registration Statement (or the most
               recent post-effective amendment thereof) which, individually or
               in the aggregate, represent a fundamental change in the
               information set forth in the Registration Statement; and

         (iii) To include any material information with respect to the plan of
               distribution not previously disclosed in the Registration
               Statement or any material change to such information in the
               Registration Statement;

         provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not
         apply if the registration statement is on Form S-3, Form S-8, or Form
         F-3, and the information required to be included in a post-effective
         amendment by those paragraphs is contained in periodic reports filed by
         the Registrant pursuant to Section 13 or Section 15(d) of the
         Securities Exchange Act of 1934 that are incorporated by reference in
         this Registration Statement.
                                      II-4
<PAGE>

     (2) That, for the purpose of determining any liability under the Securities
         Act of 1933, each such post-effective amendment shall be deemed to be a
         new registration statement relating to the securities offered therein,
         and the offering of such securities at that time shall be deemed to be
         the initial bona fide offering thereof.

     (3) To remove from registration, by means of a post-effective amendment any
         of the securities being registered which remain unsold at the
         termination of the offering.

(b)  The undersigned Registrant hereby undertakes that, for purposes of
     determining any liability under the Securities Act of 1933, each filing of
     the Registrant's annual report pursuant to Section 13(a) or Section 15(d)
     of the Securities Exchange Act of 1934 that is incorporated by reference to
     the Registration Statement shall be deemed to be a new registration
     statement relating to the securities offered therein, and the offering of
     such securities at that time shall be deemed to be the initial bona fide
     offering thereof.

(c)  Insofar as indemnification for liabilities arising under the Securities Act
     of 1933 may be permitted to directors, officers and controlling persons of
     the Registrant pursuant to the foregoing provisions, or otherwise, the
     Registrant has been advised that in the opinion of the Securities and
     Exchange Commission such indemnification is against public policy as
     expressed in the Act and is, therefore, unenforceable. In the event that a
     claim for indemnification against such liabilities (other than the payment
     by the Registrant of expenses incurred or paid by a director, officer or
     controlling person of the Registrant in the successful defense of any
     action, suit or proceeding) is asserted by such director, officer or
     controlling person in connection with the securities being registered, the
     Registrant will, unless in the opinion of its counsel the matter has been
     settled by controlling precedent, submit to a court of appropriate
     jurisdiction the question whether such indemnification by it is against
     public policy as expressed in the Act and will be governed by the final
     adjudication of such issue.








                                      II-5
<PAGE>


                                   SIGNATURES


     Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-3 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Waltham, Commonwealth of Massachusetts, September 7,
1999.


                                  DYNAGEN, INC.

                                  By /s/  C. Robert Cusick
                                     -------------------------------------
                                     President and Chief Executive Officer



     Pursuantto the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities indicated as of September 7, 1999.

<TABLE>
<CAPTION>

      SIGNATURE                         DATE                         TITLE
      ---------                         ----                         -----
<S>                               <C>                     <C>
/S/ C. ROBERT CUSICK              September 7, 1999       President, Chief Executive Officer,
 ...................................................       Treasurer and Director
C. ROBERT CUSICK                                          (Principal Executive Officer)


/S/ DHANANJAY G. WADEKAR          September 7, 1999       Executive Vice President and Director
 ...................................................       (Principal Financial and Accounting Officer)
DHANANJAY G. WADEKAR


/S/ F. HOWARD SCHNEIDER*          September 7, 1999       Director
 ...................................................
F. HOWARD SCHNEIDER


/S/ STEVEN GEORGIEV*              September 7, 1999       Director
 ...................................................
STEVEN GEORGIEV

* By Dhananjay G. Wadekar, as attorney-in-fact

</TABLE>
                                      II-6

<PAGE>
                                  EXHIBIT INDEX


EXHIBIT NO.     NAME OF EXHIBIT
- -----------
     4.1   Specimen certificate for common stock (filed as Exhibit 4a to the
           Company's Registration Statement on Form S-1, No. 33-31836-B, and
           incorporated by reference)

     4.2   Securities Purchase Agreement dated May 13, 1999 by and among the
           Company and the several purchasers named therein (previously filed)

     4.3   Form of Debenture issued in connection with the May 13, 1999
           Securities Purchase Agreement (previously filed)

     4.4   Form of Common Stock Purchase Warrant issued in connection with the
           May 13, 1999 Securities Purchase Agreement (previously filed)

     4.5   Registration Rights Agreement dated May 13, 1999 (previously filed)

     4.6   Form of Exchange Agreement dated June 29, 1999 (previously filed)

     4.7   Certificate of Designations, Preferences, and Rights of Series I
           Preferred Stock (previously filed)

     5.1   Opinion of Foley, Hoag & Eliot LLP (previously filed)

    23.1   Consent of Wolf & Company, P.C.

    23.2   Consent of Foley, Hoag & Eliot LLP (previously filed)

    24.1   Powers of Attorney (previously filed)






                                      II-7


                                                                    EXHIBIT 23.1

                          INDEPENDENT AUDITORS' CONSENT

     We consent to the incorporation by reference in this Amendment No. 1 to
Registration Statement on Form S-3 of DynaGen, Inc. (the "Company") of our
report dated February 12, 1999, except for Note 13, as to which the date is
March 29, 1999, appearing in the Company's Annual Report on Form 10-KSB for the
year ended December 31, 1998, and to the reference to us under the heading
"Experts" in the prospectus which is part of this Registration Statement.



                                                /s/ Wolf & Company, P.C.
                                                ------------------------
                                                WOLF & COMPANY, P.C.


Boston, Massachusetts
September 8, 1999



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