DYNAGEN INC
S-3, 2000-09-19
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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   AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON SEPTEMBER 15, 2000
                                                    Registration No.
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                               -------------------

                                    FORM S-3
             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

                               -------------------

                                  DYNAGEN, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

            DELAWARE                                            04-3029787
  (STATE OR OTHER JURISDICTION                               (I.R.S. EMPLOYER
OF INCORPORATION OR ORGANIZATION)                         IDENTIFICATION NUMBER)


                         1000 WINTER STREET, SUITE 2700
                          WALTHAM, MASSACHUSETTS 02451
                                 (781) 890-0021
          (ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING
             AREA CODE, OF REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES)

                               -------------------

                                C. ROBERT CUSICK
                      PRESIDENT AND CHIEF EXECUTIVE OFFICER
                                  DYNAGEN, INC.
                         1000 WINTER STREET, SUITE 2700
                          WALTHAM, MASSACHUSETTS 02451
                                 (781) 890-0021
            (NAME, ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER,
                   INCLUDING AREA CODE, OF AGENT FOR SERVICE)

                               -------------------

                                   COPIES TO:
                             DAVID A. BROADWIN, ESQ.
                             FOLEY, HOAG & ELIOT LLP
                             ONE POST OFFICE SQUARE
                           BOSTON, MASSACHUSETTS 02109
                                 (617) 832-1259

                              -------------------


      APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: As soon
as practicable after this Registration Statement becomes effective.
      If the only securities being registered on this Form are being offered
pursuant to dividend or interest reinvestment plans, please check the following
box.  [ ]
      If any of the securities being registered on this Form are to be offered
on a delayed or continuous basis pursuant to Rule 415 under the Securities Act
of 1933, other than securities offered only in connection with dividend or
interest reinvestment plans, check the following box. [X]
      If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. [ ]
      If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [ ]
      If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box.  [ ]

<TABLE><CAPTION>
                         CALCULATION OF REGISTRATION FEE
===================================================================================================================
                                                        PROPOSED             PROPOSED
                                        AMOUNT           MAXIMUM              MAXIMUM
    TITLE OF EACH CLASS OF              TO BE         OFFERING PRICE        AGGREGATE                AMOUNT OF
 SECURITIES TO BE REGISTERED          REGISTERED       PER SHARE (1)      OFFERING PRICE (1)     REGISTRATION FEE
-------------------------------------------------------------------------------------------------------------------
<S>                                  <C>               <C>                <C>                    <C>
Common Stock, $.01 par value.....     13,060,136           $0.321          $4,179,243.52             $1,103.32
===================================================================================================================
</TABLE>

(1)   Estimated solely for the purposes of determining the registration fee. In
      accordance with Rule 457(c) under the Securities Act of 1933, the above
      calculation is based on average of the high and low prices reported on the
      OTC Bulletin Board on September 12, 2000.

                               -------------------

      THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME
EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(A),
MAY DETERMINE.
================================================================================
<PAGE>

                                   PROSPECTUS



                                  DYNAGEN, INC.

THE INFORMATION IN THIS PROSPECTUS IS NOT COMPLETE AND MAY BE CHANGED. WE MAY
NOT SELL THESE SECURITIES UNTIL THE REGISTRATION STATEMENT FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION IS EFFECTIVE. THIS PROSPECTUS IS NOT AN OFFER
TO SELL SECURITIES, AND WE ARE NOT SOLICITING OFFERS TO BUY THESE SECURITIES IN
ANY STATE WHERE THE OFFER OR SALE IS NOT PERMITTED.

                 SUBJECT TO COMPLETION, DATED SEPTEMBER 15, 2000

                                13,060,136 SHARES
                                  COMMON STOCK

     The selling stockholders are offering 13,060,136 shares of common stock. We
will not receive any of the proceeds from sales of shares by the selling
stockholders.

     The selling stockholders may sell these shares from time to time in the
over-the-counter market, on the Boston Stock Exchange or otherwise.

     DynaGen's common stock is traded on the Boston Stock Exchange under the
symbol "DYG" and quoted on the OTC Bulletin Board under the symbol "DYGN." The
last reported sale price of the common stock on the OTC Bulletin Board on
September 12, 2000 was $.32 per share.

                         ------------------------------

                  INVESTING IN THE COMMON STOCK INVOLVES RISKS.
                     SEE "RISK FACTORS" BEGINNING ON PAGE 5.

                         ------------------------------

     THE SECURITIES AND EXCHANGE COMMISSION AND STATE SECURITIES REGULATORS HAVE
NOT APPROVED OR DISAPPROVED THESE SECURITIES, OR DETERMINED IF THIS PROSPECTUS
IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL
OFFENSE.




               The date of this prospectus is September __, 2000.
<PAGE>

     YOU SHOULD RELY ONLY ON THE INFORMATION CONTAINED IN THIS DOCUMENT OR TO
WHICH WE HAVE REFERRED YOU. WE HAVE NOT AUTHORIZED ANYONE TO PROVIDE YOU WITH
INFORMATION THAT IS DIFFERENT. THIS DOCUMENT MAY BE USED ONLY WHERE IT IS LEGAL
TO SELL THESE SECURITIES. THE INFORMATION IN THIS DOCUMENT IS ACCURATE ONLY AS
OF THE DATE OF THIS DOCUMENT, REGARDLESS OF THE TIME OF THE DELIVERY OF THIS
PROSPECTUS OR OF ANY SALE OF OUR COMMON STOCK.


                         ------------------------------


                                TABLE OF CONTENTS


                                                                           PAGE
                                                                          ------

Summary...................................................................   3
Risk Factors..............................................................   5
Forward-Looking Statements................................................   8
Use of Proceeds...........................................................   8
Dividend Policy...........................................................   9
Selling Stockholders......................................................   9
Plan of Distribution......................................................  11
Legal Matters.............................................................  12
Experts...................................................................  12
Disclosure of SEC Position on Indemnification for
     Securities Act Liabilities ..........................................  13
Where You Can Find More Information.......................................  13


     We own or have rights to various trademarks and trade names used in our
business. These include DYNAGEN, ABLE, SUPERIOR, GDI, and others. This
prospectus also refers to trademarks and trade names of other companies.








                                        2
<PAGE>
                                     SUMMARY

     BECAUSE THIS IS ONLY A SUMMARY, IT DOES NOT CONTAIN ALL THE INFORMATION
THAT MAY BE IMPORTANT TO YOU. YOU SHOULD READ THE ENTIRE PROSPECTUS CAREFULLY
BEFORE YOU DECIDE TO PURCHASE THE SHARES OF COMMON STOCK BEING OFFERED BY THIS
PROSPECTUS. YOU SHOULD ALSO CAREFULLY CONSIDER THE INFORMATION PROVIDED IN THIS
PROSPECTUS UNDER THE HEADING "RISK FACTORS."

                                     DYNAGEN

INTRODUCTION:         We develop, manufacture and distribute generic drugs.
                      Generic drugs compete with brand-name drugs for which
                      patent protection or other government-mandated market
                      exclusivity has expired. Generic drugs are the chemical
                      and therapeutic equivalents of brand-name drugs. They are
                      required to meet the same governmental standards as the
                      brand-name drugs they replace, and they must meet all FDA
                      guidelines. Generic drugs are typically sold under their
                      generic chemical names at prices significantly below those
                      of their brand-name equivalents. We estimate that the U.S.
                      market for generic drugs approximates $13 billion in
                      annual sales. This market has grown due to a number of
                      factors, including:

                      o               a significant number of widely-prescribed
                                      brand-name drugs are at or near the end of
                                      their period of patent protection, making
                                      it permissible for generic manufacturers
                                      to produce and market competing generic
                                      drugs;

                      o               managed care organizations, which prefer
                                      lower-cost generics to brand-name
                                      products, are capturing a greater share of
                                      the healthcare market; and

                      o               physicians, pharmacists and consumers
                                      increasingly accept generic drugs as an
                                      alternative to brand-name drugs.

OUR BUSINESS:         We intend to compete with other generic drug companies by
                      combining two key elements of the business: manufacturing
                      and distribution. We have acquired three operating
                      subsidiaries to effect this integration:

                      ABLE LABS:      In August 1996, we acquired Able
                                      Laboratories, Inc., including its
                                      46,000-square foot tablet and suppository
                                      manufacturing facility in South
                                      Plainfield, New Jersey.

                      SUPERIOR:       In June 1997, we acquired Superior
                                      Pharmaceutical Company, a generic drug
                                      distributor in Cincinnati, Ohio.

                      GENERIC
                      DISTRIBUTORS:   In March 1998, we acquired Generic
                                      Distributors Limited Partnership, a
                                      distributor of generic drugs based in
                                      Monroe, Louisiana.

OUR ADDRESS:          Our corporate headquarters is at 1000 Winter Street, Suite
                      2700, Waltham, MA 02451. The telephone number at our
                      corporate office is (781) 890-0021, and the facsimile
                      number is (781) 890-0118.

                                        3
<PAGE>

SPECIAL
CONSIDERATIONS
AND RISK FACTORS:     An investment in our common stock involves substantial
                      risks. In the section of this prospectus entitled "Risk
                      Factors," beginning on page 5, we have described several
                      matters which we believe are significant and which you
                      should consider very carefully before you decide to invest
                      in the common stock. There are two specific factors to
                      which we want to draw your attention:

                      o              our independent auditors, in their opinion
                                     on our financial statements as of December
                                     31, 1999 and for the year then ended,
                                     expressed substantial doubt as to our
                                     ability to continue as a going concern; and

                      o              we need significant additional financing
                                     to continue operations.



                                  THE OFFERING

COMMON STOCK
OFFERED:              All of the 13,060,136 shares offered by this prospectus
                      are being sold by the selling stockholders. The selling
                      stockholders hold shares of common stock as well as
                      convertible preferred stock and warrants to purchase
                      common stock which they acquired in private transactions
                      in December 1998, April 1999, April 2000 and July 2000.

USE OF PROCEEDS:      We will not receive any of the proceeds from sales of
                      shares by the selling stockholders.













                                        4
<PAGE>
                                  RISK FACTORS

     BEFORE YOU INVEST IN OUR COMMON STOCK, YOU SHOULD BE AWARE THAT THERE ARE
VARIOUS RISKS, INCLUDING THOSE DESCRIBED BELOW. WE HAVE SET FORTH BELOW THE
MATERIAL RISK FACTORS NECESSARY TO MAKE AN INFORMED INVESTMENT DECISION. YOU
SHOULD CAREFULLY CONSIDER THESE RISK FACTORS, TOGETHER WITH ALL OF THE OTHER
INFORMATION INCLUDED IN THIS PROSPECTUS, INCLUDING INFORMATION INCORPORATED BY
REFERENCE, BEFORE YOU DECIDE WHETHER TO PURCHASE SHARES OF OUR COMMON STOCK.

     IF WE CONTINUE TO INCUR LOSSES, THEN THE VALUE OF OUR COMMON STOCK WILL
     LIKELY DECLINE

     We have incurred operating losses in every operating period since our
inception. We had an accumulated deficit of $59,883,293 as of June 30, 2000. We
incurred a net loss of $1,578,422 in the six months ended June 30, 2000. We
anticipate future losses, and we can give no assurance that we will ever
generate substantial revenues from our business, or achieve profitability. If we
continue to incur operating losses, then the value of our common stock will
likely decline and you could lose your investment.

     Our losses have resulted principally from expenses we incurred in research
and development activities, and from general and administrative costs associated
with our development efforts. In addition, our Able subsidiary has incurred
operating losses, primarily because its revenues have not equaled its expenses.
To continue development of our current and proposed products, we will need to
expend substantial additional resources to conduct further product development
and to establish and expand our manufacturing, sales, marketing, regulatory and
administrative capabilities. Therefore, we expect to incur substantial operating
losses over the next several years as we expand our product programs and
commence marketing efforts.

     IF WE CANNOT RAISE SIGNIFICANT ADDITIONAL FUNDS, THEN WE WILL HAVE TO
     SUBSTANTIALLY CURTAIL OUR OPERATIONS

     Our history of operating losses raises substantial doubt about our ability
to continue operations. If we are unable to secure significant additional
financing or to renegotiate our agreements with our existing creditors, we will
have to curtail or suspend our research and development activities and other
business activities. If that happens, you could lose your entire investment. Our
independent auditors issued an opinion on our financial statements as of
December 31, 1999 and for the year then ended which included an explanatory
paragraph expressing substantial doubt about our ability to continue as a going
concern. The reasons cited by the independent auditors include the following:

     o      we have incurred recurring losses from operations resulting in a
            working capital deficiency at December 31, 1999; and

     o      we have defaulted on conditions placed upon us by our bank and other
            lenders.

     WE ARE IN DEFAULT OF CERTAIN LOAN COVENANTS WITH RESPECT TO OUR WORKING
     CAPITAL LOAN AND NEED TO ARRANGE AN ALTERNATE DEBT FACILITY

     As of June 30, 2000, we were in default of certain loan covenants under our
working capital loan with FleetBoston. We have agreed with the bank to limit our
borrowing on this line to $8.5 million. We have indicated to the bank that we
will seek an alternate lender to maximize our borrowing on our assets. Initially
we expected to reach an agreement with a replacement lender by August 2000, but
we have not met that schedule. We are continuing to seek an alternate lender,
but we may be unable to secure an alternate lender on terms acceptable to us.
FleetBoston may require us to repay the total amount due under the line of
credit at any time. If FleetBoston requires us to repay the total amount due
under the line of credit, we may not have the funds to do so, which could result
in an immediate and material adverse effect on our business.

                                        5
<PAGE>

     WE FACE INTENSE COMPETITION FROM OTHER MANUFACTURERS OF GENERIC DRUGS

     In order to succeed in the generic drug business, we need to achieve a
significant share of the market for each generic drug we market. The generic
drug manufacturing and distribution business is highly competitive. We compete
with several companies that are better capitalized than we are and that have
financial and human resources significantly greater than ours. Because we
manufacture generic drugs, our products by their very nature are chemically and
biologically equivalent to the products of our larger and profitable
competitors. Also, we believe that, as a rule, the first one or two companies to
bring a generic alternative to the market will capture the highest market share
for that product. These larger companies, with their greater resources, could
bring products to market before us, and could capture a significant share of the
market at our expense.

     IF THE BOSTON STOCK EXCHANGE DELISTS OUR COMMON STOCK, WE WILL HAVE GREATER
     DIFFICULTY RAISING THE CAPITAL WE NEED TO CONTINUE OPERATIONS

     Our common stock has been delisted from the Nasdaq Stock Market and is
listed on the Boston Stock Exchange. The common stock is also quoted on the OTC
Bulletin Board. If the common stock was delisted by the Boston Stock Exchange,
then public perception of the value of the common stock could be materially
adversely affected. You could lose your investment and we could face greater
difficulty raising capital necessary for our continued operations.

     We received a notice from the Boston Stock Exchange on April 12, 1999
informing us that our common stock did not meet the requirements for continued
listing. On July 8, 1999, we advised the Boston Stock Exchange that as of that
date we met the requirement. Our common stock remains listed on the Boston Stock
Exchange. Our common stock could face delisting action again, however, if we do
not maintain the minimum stockholders' equity or other listing requirements.

     IF OUR COMMON STOCK BECOMES SUBJECT TO PENNY STOCK RULES, YOU MAY HAVE
     GREATER DIFFICULTY SELLING YOUR SHARES

     The Securities Enforcement and Penny Stock Reform Act of 1990 applies to
stock characterized as "penny stocks," and requires additional disclosure
relating to the market for penny stocks in connection with trades in any stock
defined as a penny stock. The Securities and Exchange Commission has adopted
regulations that generally define a penny stock to be any equity security that
has a market price of less than $5.00 per share, subject to certain exceptions.
The exceptions include exchange-listed equity securities and any equity security
issued by an issuer that has

     o      net tangible assets of at least $2,000,000, if the issuer has been
            in continuous operation for at least three years;

     o      net tangible assets of at least $5,000,000, if the issuer has been
            in continuous operation for less than three years; or

     o      average annual revenue of at least $6,000,000 for the last three
            years.

Unless an exception is available, the regulations require the delivery, prior to
any transaction involving a penny stock, of a disclosure schedule explaining the
penny stock market and the associated risks.

     If our common stock is delisted from the Boston Stock Exchange, then
trading in the common stock will be covered by Rules 15g-1 through 15g-6 and
15g-9 promulgated under the Securities Exchange Act. Under those rules,
broker-dealers who recommend such securities to persons other than their
established customers and institutional accredited investors must make a special
written suitability determination for the purchaser and must have received the
purchaser's written agreement to a transaction prior to sale. These regulations

                                        6
<PAGE>

would likely limit the ability of broker-dealers to trade in our common stock
and thus would make it more difficult for purchasers of common stock to sell
their securities in the secondary market. The market liquidity for the common
stock could be severely affected.

     WE ARE OBLIGATED TO ISSUE A LARGE NUMBER OF SHARES OF COMMON STOCK

     We are obligated to issue a large number of shares of common stock at
prices lower than market value. Therefore, the common stock could lose value if
a large number of shares are issued into the market. At September 7, 2000,
83,188,890 shares of common stock were issued and outstanding. We have issued a
large number of securities, such as options, warrants, convertible preferred
stock and convertible notes, that are convertible by their holders into shares
of common stock. As of September 7, 2000, we were obligated to issue up to
approximately 25,140,960 additional shares of common stock upon the conversion
or exercise of convertible securities and options. We have also reserved
21,730,000 shares of common stock for issuance pursuant to options granted to
our employees, officers, directors and consultants. The holders of these
convertible securities likely would only exercise their rights to acquire common
stock at times when the exercise price is lower than the price at which they
could buy the common stock on the open market. Because we would likely receive
less than current market price for any shares of common stock issued upon
exercise of options and warrants, the exercise of a large number of these
convertible securities could reduce the per-share market price of common stock
held by existing investors. Also, the exercise of a large number of convertible
securities could limit our ability to obtain additional equity capital by
selling common stock. In all likelihood, we would be able to sell shares of
common stock elsewhere on more favorable terms at the time the holders of
convertible securities chose to exercise their rights.

     THE VALUE OF THE COMMON STOCK FLUCTUATES WIDELY AND YOU COULD LOSE MONEY ON
     YOUR INVESTMENT IN OUR STOCK

     The price of our common stock has fluctuated widely in the past, and it is
likely that it will continue to do so in the future. The market price of our
common stock could fluctuate substantially based on a variety of factors,
including:

     o      quarterly fluctuations in our operating results;

     o      announcements of new products by us or our competitors;

     o      key personnel losses;

     o      sales of common stock; and

     o      developments or announcements with respect to industry standards,
            patents or proprietary rights.

     The market price of our common stock has fluctuated between $70.00 and $.05
from January 1, 1993 to June 30, 2000. Over the past twelve months, the common
stock has fluctuated between approximately $1.31 and approximately $.25, and was
approximately $.34 on September 7, 2000. These broad market fluctuations could
adversely affect the market price of our common stock, in that at the current
price, any fluctuation in the dollar price per share could constitute a
significant percentage decrease in the value of your investment. Also, when the
market price of a stock has been volatile, holders of that stock have often
instituted securities class action litigation against the company that issued
the stock. If any of our stockholders brought such a lawsuit against us, we
could incur substantial costs defending the lawsuit and we would have to divert
management time and attention away from operations. A lawsuit based on the
volatility of the stock price in whole or in part could seriously harm our
business and your investment.


                                        7
<PAGE>

     WE MAY FACE PRODUCT LIABILITY FOR WHICH WE ARE NOT ADEQUATELY INSURED

     The testing, marketing and sale of drug products for human use is
inherently risky. Liability might result from claims made directly by consumers
or by pharmaceutical companies or others selling our products. Superior, Generic
Distributors and Able presently carry product liability insurance in amounts
that we believe to be adequate, but we can give no assurance that such insurance
will remain available at a reasonable cost or that any insurance policy would
offer coverage sufficient to meet any liability arising as a result of a claim.
We can give no assurance that we will be able to obtain or maintain adequate
insurance on reasonable terms or that, if obtained, such insurance will be
sufficient to protect us against such potential liability or at a reasonable
cost. The obligation to pay any product liability claim or a recall of a product
could have a material adverse affect on our business, financial condition and
future prospects.

     INTENSE REGULATION BY GOVERNMENT AGENCIES MAY DELAY OUR EFFORTS TO
     COMMERCIALIZE OUR PROPOSED DRUG PRODUCTS

     Before we can market any generic drug, we must first obtain FDA approval of
the proposed drug and of the active drug raw materials that we use. In many
instances, our approvals cover only one source of raw materials. If raw
materials from a specified supplier were to become unavailable, we would be
required to file a supplement to our Abbreviated New Drug Application to use a
different manufacturer and revalidate the manufacturing process using a new
supplier's materials. This could cause a delay of several months in the
manufacture of the drug involved and the consequent loss of potential revenue
and market share. For example, for a period of time we were unable to acquire
the active drug for our clorazapate dipotassium product, and so we had to
discontinue production of the product. The active drug ingredient has since
become available again and we have resumed manufacturing the product.


                           FORWARD-LOOKING STATEMENTS

     Some of the information in this prospectus contains forward-looking
statements that involve substantial risks and uncertainties. You can identify
these statements by forward-looking words such as "may," "will," "expect,"
"anticipate," "believe," "estimate," "continue" and similar words. You should
read statements that contain these words carefully because they: (1) discuss our
future expectations; (2) contain projections of our future operating results or
financial condition; or (3) state other "forward-looking" information. We
believe it is important to communicate our expectations to our investors. There
may be events in the future, however, that we are not accurately able to predict
or over which we have no control. The risk factors listed in this prospectus, as
well as any cautionary language in this prospectus, provide examples of risks,
uncertainties and events that may cause our actual results to be materially
worse than the expectations we describe in our forward-looking statements.
Before you invest in our common stock, you should be aware that the occurrence
of any of the events described in the risk factors and elsewhere in this
prospectus could materially and adversely affect our business. If that happens,
the trading price of our common stock could decline and you could lose all or
part of your investment.

                                 USE OF PROCEEDS

     All of the shares of common stock offered by this prospectus are being
offered by the selling stockholders. We received proceeds from the sale of the
notes and shares of convertible preferred stock that were converted, or are
convertible, into the shares of common stock offered in this prospectus. This
money was used for working capital and general corporate purposes. We will not
receive any additional proceeds from the sale of shares by the selling
stockholders. For information about the selling stockholders, see "Selling
Stockholders."

                                        8
<PAGE>
                                 DIVIDEND POLICY

     We have never declared or paid cash dividends on our common stock. We
currently intend to retain earnings, if any, to fund our business, and therefore
we do not anticipate paying cash dividends in the foreseeable future. If we ever
earn income on which we would be entitled to declare or pay dividends, we expect
that our Board of Directors would decide whether to pay dividends after taking
into account various factors including our financial condition, results of
operations, current and anticipated cash needs, and plans for expansion.

                              SELLING STOCKHOLDERS

     All of the 13,060,161 shares offered by this prospectus are being
registered for sale for the accounts of selling stockholders. As noted in the
following table, the selling stockholders have obtained or will obtain the
common stock offered under this prospectus by converting or exercising certain
convertible securities of DynaGen that they now hold. These selling stockholders
hold shares of Series J Preferred Stock, Series M Preferred Stock and warrants
to purchase common stock, which we issued to them in private investment
transactions in December 1998, April 1999, April 2000 and July 2000.

     The table below includes, in the total number of shares offered, 1,768,387
shares of common stock that have been issued or are issuable upon conversion of
shares of Series J Preferred Stock and 9,713,930 shares of common stock that
have been issued or are issuable upon conversion of shares of Series M Preferred
Stock. Pursuant to the terms of the Series J Preferred Stock, the selling
stockholders may convert shares of Series J Preferred Stock to acquire shares of
common stock at a conversion price equal to 80% of the market price of the
common stock for the five trading days immediately preceding the conversion.
Pursuant to the terms of the Series M Preferred Stock, the selling stockholders
may convert shares of Series M Preferred Stock to acquire shares of common stock
at a conversion price equal to 80% of the market price of the common stock for
three of the five days preceding the conversion.

     The table below also includes 1,200,000 shares of common stock issuable
upon exercise of warrants issued to certain selling stockholders. The warrants
are exercisable to purchase common stock at an average exercise price of $0.375
per share. If all of the warrants were exercised, then we would receive proceeds
of approximately $450,000. However, we cannot predict whether, or how many of,
the warrants will be exercised. Also included in the table below are 300,000
shares of common stock issued to selling stockholders for services rendered in
December 1998.

     We will not receive any portion of the proceeds from the sale of shares of
common stock by the selling stockholders.

     Based on the information supplied to DynaGen by or on default of each
selling stockholder, the following table sets forth certain information
regarding the approximate number of shares owned by each selling stockholder as
of September 7, 2000, and as adjusted to reflect the sale by the selling
stockholders of the shares of common stock offered by this prospectus. No
selling stockholder has held any office or maintained any material relationship
with DynaGen, or any of our predecessors or affiliates, over the past three
years.
<TABLE><CAPTION>
--------------------------------------------------------------------------------------------------------
                                          SHARES BENEFICIALLY                       SHARES BENEFICIALLY
                                       OWNED PRIOR TO OFFERING(1)    NUMBER       OWNED AFTER OFFERING(1)(2)
                                        ------------------------    OF SHARES       --------------------
     NAME                               NUMBER        PERCENT(3)    OFFERED(4)       NUMBER     PERCENT
========================================================================================================
<S>                                     <C>           <C>           <C>              <C>        <C>
Kenilworth, LLC
Corporate Centre, Windward 1
West Bay Road
P.O. Box 31106
SMB Grand Cayman, Cayman Islands......13,912,131         14%         9,713,930      4,198,201       5.0%(5)

David Harris..........................   478,782           *           141,782        237,200          *

                                        9
<PAGE>

Phoenix Capital, Inc..................   374,768           *           374,768              0          *

James Skalko..........................   184,450           *           184,450              0          *

Stephen Guarino.......................   374,830           *           374,830              0          *

Harry & Jane Meussner.................   191,484           *           191,484              0          *

David Buchovecky......................   195,028           *           195,028              0          *

Gerald Gordon......................... 1,332,139        1.6%           383,864        948,275       1.1%

Bradley J. Donner.....................   415,490           *           375,000         40,490          *

David J. Mura.........................   390,000           *           375,000         15,000          *

John P. McAuliffe.....................   490,000           *           190,000        300,000          *

Thomas W. Schneider...................   182,650           *           182,650              0          *

James A. Battaglia, Jr................   100,000           *            80,000              0          *

Floyd Murray LLC......................    68,414           *            68,414              0          *

Thomas J. O'Rourke....................    34,125           *            34,125              0          *

Siegfried P. Duray-Bito...............    32,500           *            32,500              0          *

Jay A. Murray.........................    30,875           *            30,875              0          *

Richard J. Milham, Jr.................    90,000           *            25,000         65,000          *

Joel I. Greenspan.....................   101,000           *            21,000         80,000          *

Mitchell J. Pizzirusso................    54,000           *            21,000         33,000          *

John E. Rick..........................   221,000           *            21,000        200,000          *

Raymond J. DeRobbio...................    20,000           *            20,000              0          *

Rick J. Rouse.........................    15,436           *            15,436              0          *

Daniel P. Bailey......................    29,000           *             5,000         29,000          *

Cheryl A. Garofalo....................    15,800           *             3,000         15,800          *
</TABLE>

--------------------
*    Less than 1.0%.
(1)  Beneficial ownership is determined in accordance with the rules of the
     Securities and Exchange Commission and generally includes voting or
     investment power with respect to securities. Except as indicated, each
     person possesses sole voting and investment power with respect to all of
     the shares of common stock owned by such person, subject to community
     property laws where applicable. In computing the number of shares
     beneficially owned by a person and the percentage ownership of that person,
     shares of common stock subject to options and convertible securities held
     by that person that are currently exercisable, or become exercisable within
     60 days of the date of this prospectus are deemed outstanding. Such shares,
     however, are not deemed


                                       10
<PAGE>

     outstanding for the purpose of computing the percentage ownership of any
     other person. The information as to each person has been furnished by such
     person.
(2)  Assumes that all shares of common stock offered in this prospectus will be
     sold.
(3)  Based on 83,188,890 shares of common stock issued and outstanding as of
     September 7, 2000.
(4)  With respect to all of the selling stockholders the shares offered
     represent shares of common stock presently issued and outstanding or
     issuable upon: the exercise of common stock purchase warrants transferred
     to the selling stockholders by Schneider Securities, Inc. in April 1999
     (the original warrant was issued to Schneider Securities, Inc. in December
     1998); the conversion of shares of Series J Preferred Stock, $0.01 par
     value per share; or the conversion of Series M Preferred Stock, $0.01 par
     value per share. The shares of Series J Preferred Stock and, Series M
     Preferred Stock were transferred or sold to the selling stockholders in
     private transactions in April 1999, April 2000 and July 2000, respectively.

(5)  Pursuant to the terms of the Series M Preferred Stock, the conversion
     rights of the holders of Series M Preferred Stock are limited in that the
     number of shares of Common Stock therby issuable, together with the number
     of shares of Common Stock then held by such holder and its affiliates, may
     not exceed 4.9% of the then outstanding Common Stock of the Company, as
     determined in accordance with Section 13(d) of the Exchange Act.

                              PLAN OF DISTRIBUTION

     The shares offered by this prospectus may be sold from time to time by
selling stockholders, who consist of the persons named under "Selling
Stockholders" above and those persons' pledgees, donees, transferees or other
successors in interest. The selling stockholders may sell any or all of their
shares of common stock on the OTC Bulletin Board, on the Boston Stock Exchange
or otherwise, at fixed or negotiated prices. The selling stockholders may use
any one or more of the following methods when selling shares:

     o      ordinary brokerage transactions and transactions in which the
            broker-dealer solicits purchasers;

     o      block trades in which the broker-dealer will attempt to sell the
            shares as agent but may position and resell a portion of the block
            as principal to facilitate the transaction;

     o      purchases by a broker-dealer as principal and resale by the
            broker-dealer for its account;

     o      an exchange distribution in accordance with the rules of the
            applicable exchange;

     o      privately negotiated transactions;

     o      short sales;

     o      broker-dealers may agree with the Selling Stockholders to sell a
            specified number of such shares at a stipulated price per share;

     o      a combination of any such methods of sale; and

     o      any other method permitted pursuant to applicable law.

     The selling stockholders may also sell shares under Rule 144 under the
Securities Act, if available, rather than under this prospectus.

     The selling stockholders may also engage in short sales against the box,
puts and calls and other transactions in our securities or derivatives of our
securities and may sell or deliver shares in connection with these trades. The
selling stockholders may pledge their shares to their brokers under the margin
provisions of customer agreements. If a selling stockholder defaults on a margin
loan, the broker may, from time to time, offer and sell the pledged shares.

                                       11
<PAGE>

     Broker-dealers engaged by the selling stockholders may arrange for other
brokers-dealers to participate in sales. Broker-dealers may receive commissions
or discounts from the selling stockholders (or, if any broker-dealer acts as
agent for the purchaser of shares, from the purchaser) in amounts to be
negotiated. The selling stockholders do not expect these commissions and
discounts to exceed what is customary in the types of transactions involved.

     The selling stockholders and any broker-dealers or agents that are involved
in selling the shares may be deemed to be "underwriters" within the meaning of
the Securities Act in connection with such sales. In such event, any commissions
received by such broker-dealers or agents and any profit on the resale of the
shares purchased by them may be deemed to be underwriting commissions or
discounts under the Securities Act.

     If any selling stockholder notifies us that a material arrangement has been
entered into with a broker-dealer for the sale of shares through a block trade,
special offering, exchange distribution or secondary distribution or a purchase
by a broker or dealer, we will file a prospectus supplement, if required
pursuant to Rule 424(c) under the Securities Act of 1933, setting forth:

     o      the name of each of the participating broker-dealers;

     o      the number of shares involved;

     o      the price at which the shares were sold;

     o      the commissions paid or discounts or concessions allowed to the
            broker-dealers, where applicable;

     o      a statement to the effect that the broker-dealers did not conduct
            any investigation to verify the information set out or incorporated
            by reference in this prospectus; and

     o      any other facts material to the transaction.

     We are paying all fees and expenses incident to the registration of the
shares, including fees and disbursements of counsel to the selling stockholders.
We have agreed to indemnify the selling stockholders against certain losses,
claims, damages and liabilities, including liabilities under the Securities Act.

                                  LEGAL MATTERS

     Foley, Hoag & Eliot LLP, Boston, Massachusetts, has advised us with respect
to the validity of the shares of common stock offered by this prospectus.

                                     EXPERTS

     The financial statements for each of the two fiscal years ended December
31, 1999 and 1998, incorporated by reference in this prospectus and in the
registration statement of which this prospectus is part, have been audited by
Wolf & Company, P.C., independent public accountants, as indicated in their
report with respect to such financial statements. The incorporation by reference
in this prospectus and in the registration statement of which it is part, is in
reliance upon such reports given upon the authority of Wolf & Company as experts
in accounting and auditing.


                                       12
<PAGE>

                          DISCLOSURE OF SEC POSITION ON
                 INDEMNIFICATION FOR SECURITIES ACT LIABILITIES

     DynaGen's Restated Certificate of Incorporation and By-Laws provide that we
will indemnify our directors and officers, to the fullest extent permitted under
Delaware law, including in circumstances in which indemnification is otherwise
discretionary under Delaware law.

     Insofar as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers or controlling persons of DynaGen,
pursuant to the foregoing provisions, or otherwise, we have been advised that,
in the opinion of the SEC, such indemnification is against public policy as
expressed in the Securities Act, and is, therefore, unenforceable.

                       WHERE YOU CAN FIND MORE INFORMATION

     We file annual reports, quarterly reports, current reports, proxy
statements and other information with the Securities and Exchange Commission.
You may read and copy any of our SEC filings at the SEC's public reference room
at 450 Fifth Street, N.W., Washington D.C. 20549. You may call the SEC at
1-800-SEC-0330 for further information about the public reference room. Our SEC
filings also are available to the public on the SEC's website at
http://www.sec.gov.

     The SEC allows us to "incorporate by reference" information from certain of
our other SEC filings. This means that we can disclose information to you by
referring you to those other filings, and the information incorporated by
reference is considered to be part of this prospectus. In addition, certain
information that we file with the SEC after the date of this prospectus will
automatically update, and in some cases supersede, the information contained or
otherwise incorporated by reference in this prospectus. We are incorporating by
reference the information contained in the following SEC filings (File. No.
1-11352):

     o      Our Annual Report on Form 10-KSB for the year ended December 31,
            1999;

     o      Our Quarterly Report on Form 10-QSB for the three months ended March
            31, 2000;

     o      Our Quarterly Report on Form 10-QSB for the three months ended June
            30, 2000;

     o      The "Description of Securities" contained in our Registration
            Statement on Form 8-A filed August 19, 1992 together with all
            amendments and reports filed for the purpose of updating that
            description;

     o      All other documents we filed pursuant to Section 13(a) or 15(d) of
            the Exchange Act since the end of the fiscal year covered by the
            Annual Report referred to above; and

     o      any filings we make with the SEC under Section 13(a), 13(c), 14 or
            15(d) of the Securities Exchange Act of 1934 (i) subsequent to the
            initial filing of this prospectus and prior to the date it is
            declared effective and (ii) subsequent to the date of this
            prospectus and prior to the termination of this offering.
            Information in these filings will be incorporated as of the filing
            date.

     You may request copies of these filings, at no cost, by writing or
telephoning us as follows:

                                 Investor Relations
                                 DynaGen, Inc.
                                 1000 Winter Street, Suite 2700
                                 Waltham, Massachusetts 02154
                                 Telephone:  (781) 890-0021



                                       13
<PAGE>

     This prospectus is part of a registration statement on Form S-3 we filed
with the SEC under the Securities Act of 1933. This prospectus does not contain
all of the information contained in the registration statement. For further
information about us and our common stock, you should read the registration
statement and the exhibits filed with the registration statement.

































                                       14
<PAGE>
                                     PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS


ITEM 14. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

     The following table sets forth the various expenses to be paid by the
Registrant in connection with the issuance and distribution of the shares of
common stock being registered. All amounts shown are estimates, except for the
Securities and Exchange Commission registration fee. The Registrant will pay all
expenses in connection with the distribution of the shares of common stock being
sold by the Selling Stockholders (including fees and expenses of counsel for the
Registrant), except for the underwriting discount and for legal fees of any
counsel selected by any particular Selling Stockholder.


Securities and Exchange Commission registration fee...........      $ 1,103.32
Boston Stock Exchange listing additional shares fee...........        5,000.00
Accounting fees and expenses..................................        3,000.00
Legal fees and expenses.......................................       12,000.00
Blue sky fees and expenses, including legal fees..............        1,000.00
Printing, EDGAR formatting and mailing expenses...............        2,000.00
Miscellaneous.................................................          896.68
                                                                    ----------
        Total.................................................      $25,000.00
                                                                    ==========

ITEM 15. INDEMNIFICATION OF DIRECTORS AND OFFICERS

         (A) The Company is a Delaware corporation. Section 145 of the Delaware
General Corporation Law, as amended, provides in regard to indemnification of
directors and officers as follows:

         "(a) A corporation may indemnify any person who was or is a party or is
threatened to be made a party to any threatened, pending or completed action,
suit or proceeding, whether civil, criminal, administrative or investigative
(other than an action by or in the right of the corporation) by reason of the
fact that he is or was a director, officer, employee or agent of the
corporation, or is or was serving at the request of the corporation as a
director, officer, employee or agent of another corporation, partnership, joint
venture, trust or other enterprise, against expenses (including attorneys'
fees), judgments, fines and amounts paid in settlement actually and reasonably
incurred by him in connection with such action, suit or proceeding if he acted
in good faith and in a manner he reasonably believed to be in or not opposed to
the best interests of the corporation, and, with respect to any criminal action
or proceeding, had no reasonable cause to believe his conduct was unlawful. The
termination of any action, suit or proceeding by judgment, order, settlement,
conviction, or upon a plea of nolo contendere or its equivalent, shall not, of
itself, create a presumption that the person did not act in good faith and in a
manner which he reasonably believed to be in or not opposed to the best
interests of the corporation, and, with respect to any criminal action or
proceeding, had reasonable cause to believe that his conduct was unlawful.

         (b) A corporation may indemnify any person who was or is a party or is
threatened to be made a party to any threatened, pending or completed action or
suit by or in the right of the corporation to procure a judgment in its favor by
reason of the fact that he is or was a director, officer, employee or agent of
the corporation, or is or was serving at the request of the corporation as a
director, officer, employee or agent of another corporation, partnership, joint
venture, trust or other enterprise against expenses (including attorneys' fees)
actually and reasonably incurred by him in connection with the defense or
settlement of such action or suit if he acted in good faith and in a manner he
reasonably believed to be in or not opposed to the best interests of the
corporation and except that no indemnification shall be made in respect of any
claim, issue or matter as to which such person shall have been adjudged to be
liable to the corporation unless and only to the extent that the Court of
Chancery or the court in which such action or suit was brought shall determine
upon application that, despite the adjudication of liability but in view of all
the circumstances of the case, such person is fairly

                                      II-1
<PAGE>

and reasonably entitled to indemnity for such expenses which the Court of
Chancery or such other court shall deem proper.

         (c) To the extent that a present or former director or officer of a
corporation has been successful on the merits or otherwise in defense of any
action, suit or proceeding referred to in subsections (a) and (b) of this
section, or in defense of any claim, issue or matter therein, such person shall
be indemnified against expenses (including attorneys' fees) actually and
reasonably incurred by such person in connection therewith.

         (d) Any indemnification under subsections (a) and (b) of this section
(unless ordered by a court) shall be made by the corporation only as authorized
in the specific case upon a determination that indemnification of the present or
former director, officer, employee or agent is proper in the circumstances
because he has met the applicable standard of conduct set forth in subsections
(a) and (b) of this section. Such determination shall be made, with respect to a
person who is a director or officer at the time of such determination, (1) by
the board of directors by a majority vote of a quorum consisting of directors
who were not parties to such action, suit or proceeding, or (2) by a committee
of such directors designated by majority vote of such directors, even though
less than a quorum, or (3) if such a quorum is not obtainable, or, even if
obtainable a quorum of disinterested directors so directs, by independent legal
counsel in a written opinion, or (3) by the stockholders.

         (e) Expenses (included attorneys' fees) incurred by an officer or
director in defending any civil, criminal, administrative or investigative
action suit or proceeding may be paid by the corporation in advance of the final
disposition of such action, suit or proceeding upon receipt of an undertaking by
or on behalf of such director or officer to repay such amount if it shall
ultimately be determined that such person is not entitled to be indemnified by
the corporation as authorized in this section. Such expenses (including
attorneys' fees) incurred by former director or officers or employees and agents
may be so paid upon such terms and conditions, if any, as the corporation deems
appropriate.

         (f) The indemnification and advancement of expenses provided by, or
granted pursuant to, the other subsections of this section shall not be deemed
exclusive of any other rights to which those seeking indemnification or
advancement of expenses may be entitled under any bylaw, agreement, vote of
stockholders or disinterested directors or otherwise, both as to action in such
person's official capacity and as to action in another capacity while holding
such office.

         (g) A corporation shall have power to purchase and maintain insurance
on behalf of any person who is or was a director, officer, employee or agent of
the corporation, or is or was serving at the request of the corporation as a
director, officer, employee or agent of another corporation, partnership, joint
venture, trust or other enterprise against any liability asserted against such
person and incurred by such person in any such capacity, or arising out of such
person's status as such, whether or not the corporation would have the power to
indemnify such person against such liability under this section.

         (h) For purposes of this section, references to "the corporation" shall
include, in addition to the resulting corporation, any constituent corporation
(including any constituent of a constituent) absorbed in a consolidation or
merger which, if its separate existence had continued, would have had power and
authority to indemnify its directors, officers, and employees or agents so that
any person who was a director, officer, employee or agent of such constituent
corporation, or is or was serving at the request of such constituent corporation
as a director, officer, employee or agent of another corporation, partnership,
joint venture, trust or other enterprise, shall stand in the same position under
this section with respect to the resulting or surviving corporation as such
person would have with respect to such constituent corporation if its separate
existence had continued.

         (i) For purposes of this section, references to "other enterprises"
shall include employee benefit plans; references to "fines" shall include any
excise taxes assessed on a person with respect to any employee benefit plan; and
references to "serving at the request of the corporation" shall include any
service as a director,

                                      II-2
<PAGE>

officer, employee or agent of the corporation which imposes duties on, or
involves services by, such director, officer, employee, or agent with respect to
an employee benefit plan, its participants or beneficiaries; and a person who
acted in good faith and in a manner such person reasonably believed to be in the
interest of the participants and beneficiaries of an employee benefit plan shall
be deemed to have acted in a manner "not opposed to the best interests of the
corporation" as referred to in this section.

         (j) The indemnification and advancement of expenses provided by, or
granted pursuant to, this section shall, unless otherwise provided when
authorized or ratified, continue as to a person who has ceased to be a director,
officer, employee or agent and shall inure to the benefit of the heirs,
executors and administrators of such a person.

         (k) The Court of Chancery is hereby vested with exclusive jurisdiction
to hear and determine all actions for advancement of expenses or indemnification
brought under this section or under any bylaw, agreement, vote of stockholders
or disinterested directors, or otherwise. The Court of Chancery may summarily
determine a corporation's obligation to advance expenses."

         (B) Article 9 of the Company's Certificate of Incorporation contains
the following provision relating to the indemnification of directors and
officers:

         "To the maximum extent permitted by Section 102(b)(7) of the General
Corporation Law of Delaware, a director of this Corporation shall not be
personally liable to the Corporation or its stockholders for monetary damages
for breach of fiduciary duty as a director, except for liability (i) for any
breach of the director's duty of loyalty to the Corporation or its stockholders,
(ii) for acts or omissions not in good faith or which involve intentional
misconduct or a knowing violation of law, (iii) under Section 174 of the
Delaware General Corporation Law, or (iv) for any transaction from which the
director derived an improper personal benefit."

     (C) Article VII of the Company's By-laws contains the following provisions
relating to indemnification of officers and directors:

         "Reference is made to Section 145 and any other relevant provisions of
the General Corporation Law of the State of Delaware. Particular reference is
made to the class of persons, hereinafter called "Indemnitees," who may be
indemnified by a Delaware corporation pursuant to the provisions of such Section
145, namely, any person or the heirs, executors, or administrators of such
person, who was or is a party or is threatened to be made a party to any
threatened, pending or completed action, suit, or proceeding, whether civil,
criminal, administrative, or investigative, by reason of the fact that such
person is or was a director, officer, employee, or agent of such corporation or
is or was serving at the request of such corporation as a director, officer,
employee, or agent of such corporation or is or was serving at the request of
such corporation as a director, officer, employee or agent of another
corporation, partnership, joint venture, trust, or other enterprise. The
Corporation shall, and is hereby obligated to, indemnify the Indemnitees, and
each of them in each and every situation where the Corporation is obligated to
make such indemnification pursuant to the aforesaid statutory provisions. The
Corporation shall indemnify the Indemnitees, and each of them, in each and every
situation where, under the aforesaid statutory provisions, the Corporation is
not obligated, but is nevertheless permitted or empowered, to make such
indemnification, it being understood that, before making such indemnification
with respect to any situation covered under this sentence, (i) the Corporation
shall promptly make or cause to be made, by any of the methods referred to in
Subsection (d) of such Section 145, a determination as to whether each
Indemnitee acted in good faith and in a manner he reasonably believed to be in,
or not opposed to, the best interests of the Corporation, and, in the case of
any criminal action or proceeding, had no reasonable cause to believe that his
conduct was unlawful, and (ii) that no such indemnification shall be made unless
it is determined that such Indemnitee acted in good faith and in a manner he
reasonably believed to be in, or not opposed to, the best interests of the
Corporation, and, in the case of any criminal action or proceeding, had no
reasonable cause to believe that his conduct was unlawful."

                                      II-3
<PAGE>

         The effect of these provisions would be to permit indemnification by
the Company of for, among other liabilities, liabilities arising under the
Securities Act of 1933 (the "Securities Act").


ITEM 16. EXHIBITS


 EXHIBIT NO.       NAME OF EXHIBIT
 -----------       ---------------

    4.1            Specimen certificate for common stock filed as Exhibit 4.1 to
                   the Company's Registration Statement on Form S-1, No.
                   33-31836-B and incorporated by reference)

    4.2            Subscription Agreement for Series J Preferred Stock (filed as
                   Exhibit 10.1 to the Company's Quarterly Report of Form 10-QSB
                   for the quarter ended September 30, 1999 and incorporated
                   herein by reference)

    4.3            Certificate of Designations, Preferences, and Rights of
                   Series J Preferred Stock (filed as Exhibit 3.3 to the
                   Company's Quarterly Report of Form 10-QSB for the quarter
                   ended September 30, 1999 and incorporated herein by
                   reference)

    4.4            Registration Rights Agreement for Series J Preferred Stock
                   (filed as Exhibit 10.2 to the Company's Quarterly Report of
                   Form 10-QSB for the quarter ended September 30, 1999 and
                   incorporated herein by reference)

    4.5            Convertible Preferred Stock Purchase Agreement for Series M
                   Preferred Stock dated July 17, 2000

    4.6            Certificate of Designations, Preferences, and Rights of
                   Series M Preferred Stock

    4.7            Registration Rights Agreement for Series M Preferred Stock
                   dated July 17, 2000

    4.8            Form of Common Stock Purchase Warrant transferred by
                   Schneider Securities, Inc. in April 1999 to certain
                   individuals to purchase an aggregate of 1,200,000 shares of
                   common stock

    5.1            Opinion of Foley, Hoag & Eliot LLP

    23.1           Consent of Wolf & Company, P.C.

    23.2           Consent of Foley, Hoag & Eliot LLP (included in Exhibit 5.1)

    24.1           Power of Attorney (included on signature page)

----------------


ITEM 17. UNDERTAKINGS

(a)  The undersigned Registrant hereby undertakes:

     (1) To file, during any period in which offers or sales are being made, a
         post-effective amendment to this Registration Statement;

         (i)   To include any prospectus required to Section 10(a)(3) of the
               Securities Act of 1933;

         (ii)  To reflect in the prospectus any facts or events arising after
               the effective date of the Registration Statement (or the most
               recent post-effective amendment thereof) which, individually or
               in the aggregate, represent a fundamental change in the
               information set forth in the Registration Statement; and


                                      II-4
<PAGE>
         (iii) To include any material information with respect to the plan of
               distribution not previously disclosed in the Registration
               Statement or any material change to such information in the
               Registration Statement;

         PROVIDED, HOWEVER, that paragraphs (a)(1)(i) and (a)(1)(ii) do not
         apply if the registration statement is on Form S-3, Form S-8, or Form
         F-3, and the information required to be included in a post-effective
         amendment by those paragraphs is contained in periodic reports filed by
         the Registrant pursuant to Section 13 or Section 15(d) of the
         Securities Exchange Act of 1934 that are incorporated by reference in
         this Registration Statement.

     (2) That, for the purpose of determining any liability under the Securities
         Act of 1933, each such post-effective amendment shall be deemed to be a
         new registration statement relating to the securities offered therein,
         and the offering of such securities at that time shall be deemed to be
         the initial BONA FIDE offering thereof.

     (3) To remove from registration, by means of a post-effective amendment any
         of the securities being registered which remain unsold at the
         termination of the offering.

(b)  The undersigned Registrant hereby undertakes that, for purposes of
     determining any liability under the Securities Act of 1933, each filing of
     the Registrant's annual report pursuant to Section 13(a) or Section 15(d)
     of the Securities Exchange Act of 1934 that is incorporated by reference to
     the Registration Statement shall be deemed to be a new registration
     statement relating to the securities offered therein, and the offering of
     such securities at that time shall be deemed to be the initial BONA FIDE
     offering thereof.

(c)  Insofar as indemnification for liabilities arising under the Securities Act
     of 1933 may be permitted to directors, officers and controlling persons of
     the Registrant pursuant to the foregoing provisions, or otherwise, the
     Registrant has been advised that in the opinion of the Securities and
     Exchange Commission such indemnification is against public policy as
     expressed in the Act and is, therefore, unenforceable. In the event that a
     claim for indemnification against such liabilities (other than the payment
     by the Registrant of expenses incurred or paid by a director, officer or
     controlling person of the Registrant in the successful defense of any
     action, suit or proceeding) is asserted by such director, officer or
     controlling person in connection with the securities being registered, the
     Registrant will, unless in the opinion of its counsel the matter has been
     settled by controlling precedent, submit to a court of appropriate
     jurisdiction the question whether such indemnification by it is against
     public policy as expressed in the Act and will be governed by the final
     adjudication of such issue.

                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-3 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Waltham, Commonwealth of Massachusetts, September 15,
2000.
                                           DYNAGEN, INC.

                                           By: /s/ C. Robert Cusick
                                           -------------------------------------
                                           President and Chief Executive Officer


                                      II-5
<PAGE>

                                POWER OF ATTORNEY

     We, the undersigned officers and directors of DynaGen, Inc., hereby
severally constitute and appoint each of C. Robert Cusick and Dhananjay G.
Wadekar our true and lawful attorney with full power to sign for us and in our
names in the capacities indicated below, any and all pre-effective and
post-effective amendments to the Registration Statement on Form S-3 filed
herewith, and any subsequent Registration Statement for the same offering which
may be filed under Rule 462(b) under the Securities Act of 1933, and generally
to do all such things in our names and on our behalf in our capacities as
officers and directors to enable DynaGen, Inc. to comply with the provisions of
the Securities Act of 1933 and all requirements of the Securities and Exchange
Commission, hereby ratifying and confirming our signatures as they may be signed
by our said attorneys, or any of them, to any and all amendments to said
Registration Statement or to any subsequent Registration Statement for the same
offering that may be filed under said Rule 462(b).


     Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities indicated as of September 14, 2000.

<TABLE><CAPTION>

        SIGNATURE                            DATE                              TITLE
        ---------                            ----                              -----
<S>                                    <C>                       <C>

/s/  C. Robert Cusick                  September 14, 2000        President, Chief Executive Officer and
 ...............................                                  Director (PRINCIPAL EXECUTIVE OFFICER)
     C. Robert Cusick


/s/  Dhananjay G. Wadekar              September 14, 2000        Executive Vice President, Treasurer and Director
 ...............................                                  (PRINCIPAL FINANCIAL AND ACCOUNTING OFFICER)
     Dhananjay G. Wadekar


/s/  F. Howard Schneider               September 14, 2000        Director
 ...............................
     F. Howard Schneider


/s/  Harry Silverman                   September 14, 2000        Director
 ...............................
     Harry Silverman


/s/  James B. Klint                    September 14, 2000        Director
 ...............................
     James B. Klint

</TABLE>
                                      II-6
<PAGE>
                                  EXHIBIT INDEX


 EXHIBIT NO.       NAME OF EXHIBIT
 -----------       ---------------

    4.1            Specimen certificate for common stock filed as Exhibit 4.1 to
                   the Company's Registration Statement on Form S-1, No.
                   33-31836-B and incorporated by reference)

    4.2            Subscription Agreement for Series J Preferred Stock (filed as
                   Exhibit 10.1 to the Company's Quarterly Report of Form 10-QSB
                   for the quarter ended September 30, 1999 and incorporated
                   herein by reference)

    4.3            Certificate of Designations, Preferences, and Rights of
                   Series J Preferred Stock (filed as Exhibit 3.3 to the
                   Company's Quarterly Report of Form 10-QSB for the quarter
                   ended September 30, 1999 and incorporated herein by
                   reference)

    4.4            Registration Rights Agreement for Series J Preferred Stock
                   dated (filed as Exhibit 10.2 to the Company's Quarterly
                   Report of Form 10-QSB for the quarter ended September 30,
                   1999 and incorporated herein by reference)

    4.5            Convertible Preferred Stock Purchase Agreement for Series M
                   Preferred Stock dated July 17, 2000

    4.6            Certificate of Designations, Preferences, and Rights of
                   Series M Preferred Stock

    4.7            Registration Rights Agreement for Series M Preferred Stock
                   dated July 17, 2000

    4.8            Form of Common Stock Purchase Warrant

    5.1            Opinion of Foley, Hoag & Eliot LLP

    23.1           Consent of Wolf & Company, P.C.

    23.2           Consent of Foley, Hoag & Eliot LLP (included in Exhibit 5.1)

    24.1           Power of Attorney (included on signature page)





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