PROTEIN POLYMER TECHNOLOGIES INC
S-8, 1998-07-28
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>
 
As filed with the Securities and Exchange Commission on July 28, 1998
                                          Registration No. 33-..................
- --------------------------------------------------------------------------------
                       SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549
                                  ___________

                                    FORM S-8
            REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
                                  ___________

                       PROTEIN POLYMER TECHNOLOGIES, INC.
               (Exact name of registrant as specified in charter)


          DELAWARE                                       33-0311631
(State or other jurisdiction of                       (I.R.S. Employer
 incorporation or organization)                      Identification No.)

 
       10655 SORRENTO VALLEY ROAD                              
        SAN DIEGO, CALIFORNIA                                  92121 
(Address of Principal Executive Offices)                     (Zip Code) 

                                   _________

                       PROTEIN POLYMER TECHNOLOGIES, INC.
                             1992 STOCK OPTION PLAN
                            (Full title of the plan)

                               J. THOMAS PARMETER
                       Chairman & Chief Executive Officer
                       PROTEIN POLYMER TECHNOLOGIES, INC.
                           10655 Sorrento Valley Road
                          San Diego, California  92121
                    (Name and address of agent for service)

                                 (619) 558-6064

         (Telephone number, including area code, of agent for service)
                                   _________
<TABLE> 
<CAPTION> 

                                                          CALCULATION OF REGISTRATION FEE
- ------------------------------------------------------------------------------------------------------------------------------------

                                                                 Proposed              Proposed
                                                                  Maximum              Maximum
          Title of Securities               Amount to be      Offering Price          Aggregate              Amount of
           to be Registered                  Registered        Per Share (1)      Offering Price (1)     Registration Fee
- ------------------------------------------------------------------------------------------------------------------------------------

<S>                                       <C>                <C>                 <C>                    <C>
Common Stock, $.01 par value                 500,000(2)(3)         $1.50               $750,000                  $221.25
                                                                                                       
Options to purchase shares of Common           500,000(4)          $-0-(4)             $-0-(4)                   $-0-(4)    
 Stock, par value $.01 per share (4)
- ------------------------------------------------------------------------------------------------------------------------------------

</TABLE>

(1) Estimated solely for the purpose of calculating the amount of the
    registration fee in accordance with Rule 457 under the Securities Act of
    1933, as amended. The Proposed Maximum Aggregate Offering Price is based on
    the last sale price as quoted on the National Association of Securities
    Dealers Automated Quotation System on July 22, 1998 of $1.50 per share.
(2) Excludes all shares previously registered under Registrant's 1992 Stock
    Option Plan on Form S-8 Registration Statement (Registration No. 33-63046).
(3) This Registration Statement covers, in addition to such number of shares
    issuable upon exercise of the Options to be granted under the Company's 1992
    Stock Option Plan, an indeterminate number of additional shares which may
    become subject to Options as a result of the adjustment provisions of the
    Plan.  The registration fee is calculated only on the stated number of
    shares.
(4) The Options to be registered hereunder are being registered for the sole
    purpose of permitting the Company to qualify the Options by coordination in
    California. Because the Options will be distributed without charge to Plan
    participants, no separate registration fee is required.
- --------------------------------------------------------------------------------
<PAGE>
 
                                  PART II/1/


              INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3.   INCORPORATION OF DOCUMENTS BY REFERENCE

          The following documents are hereby incorporated into this Registration
Statement and made a part hereof by this reference:

(a)       The Annual Report on Form 10-KSB of Protein Polymer Technologies, Inc.
          (the "Company" or "Registrant") for the fiscal year ended December 31,
          1997 filed with the Securities and Exchange Commission (the
          "Commission") on April 15, 1998 pursuant to the Securities Exchange
          Act of 1934, as amended (the "Exchange Act");

(b)       The Current Report on Form 8-K, filed with the Commission on May 1,
          1998;

(c)       The Quarterly Report on Form 10-QSB for the quarter ended March 31,
          1998 filed with the Commission on May 15, 1998;

(d)       The description of the Company's Common Stock contained in the
          Company's Registration Statement under the Exchange Act on Form 8-A,
          filed with the Commission on December 11, 1991, as amended by Form 8
          filed on January 17, 1992 and by Form 8-A, filed with the Commission
          on September 5, 1997; and

(e)       Registration Statement on Form S-8, filed May 20, 1993 (Registration
          No. 33-63046), registering 1,000,000 shares of the Company's Common
          Stock, reserved under the 1992 Stock Option Plan, under the Securities
          Act.

          In addition, all documents filed by the Company with the Commission
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act subsequent
to the date of this Registration Statement, and prior to the filing of a post-
effective amendment which indicates that all securities offered have been sold
or which deregisters all securities then remaining unsold, shall be deemed to be
incorporated by reference into this Registration Statement and to be a part
hereof from the date of the filing of such documents with the Commission.





/1/   Information required by Part I of Form S-8 is contained in a Section 10(a)
      prospectus to be distributed to each optionee and is omitted from this
      Registration Statement in accordance with Rule 428 promulgated under the
      Securities Act and the Note to Part I of Form S-8.

                                      -2-
<PAGE>
 
ITEMS 4-7.  DESCRIPTION OF SECURITIES; INTERESTS OF NAMED EXPERTS AND COUNSEL;
            INDEMNIFICATION OF DIRECTORS AND OFFICERS; EXEMPTION FROM
            REGISTRATION CLAIMED.

                 Items 4 through 7, inclusive, are omitted in reliance upon
General Instruction E to Form S-8, and the above incorporation by reference of a
previously filed and currently effective Form S-8 (see Item 3, subpart (e)
above) registering securities of the same class under the same plan as those
registered on this Form S-8.

ITEM 8.  EXHIBITS

<TABLE> 
<CAPTION> 

         Exhibit
         -------
         <S>   <C> 
          4.1  The Company's 1992 Stock Option Plan, as amended.

          5.1  Opinion of counsel as to legality of securities being registered.

          23.1  Consent of Ernst & Young LLP, independent auditors.

          23.2  Consent of counsel (included in Exhibit 5.1).

          24.1  Power of Attorney (included herein on the signature page).
</TABLE> 

ITEM 9.  UNDERTAKINGS.

         Item 9 is omitted in reliance upon General Instruction E to Form S-8,
and the above incorporation by reference of a previously filed and currently
effective Form S-8 (see Item 3, subpart (e) above) registering securities of the
same class under the same plan as those registered on this Form S-8.

                                      -3-
<PAGE>
 
                                   SIGNATURES


       Pursuant to the requirements of the Securities Act of 1933, the
registrant certifies  that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of San Diego, State of California, on July 28,
1998.


                            PROTEIN POLYMER TECHNOLOGIES, INC.,
                            a Delaware corporation



                            By:/s/ J. THOMAS PARMETER
                               ------------------------------------
                               J. Thomas Parmeter
                               President & Chief Executive Officer

<PAGE>
 
                               POWER OF ATTORNEY

      KNOW ALL MEN BY THESE PRESENTS, that each individual whose signature
appears below constitutes and appoints J. Thomas Parmeter and Aron P. Stern, and
each of them, his true and lawful attorney-in-fact and agent, each acting alone,
with full power of substitution and resubstitution, for him and in his name,
place and stead, in any and all capacities, to sign this Registration Statement
and any and all amendments (including post-effective amendments) to this
Registration Statement, and to file the same with all exhibits thereto, and all
documents in connection therewith, with the Securities and Exchange Commission,
granting unto said attorney-in-fact and agent, full power and authority to do
and perform each and every act and thing requisite and necessary to be done in
and about the premises, as fully to all intents and purposes as he might or
could do in person, hereby ratifying and confirming all that said attorney-in-
fact and agent or his substitute or substitutes, may lawfully do or cause to be
done by virtue thereof.

      Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.

<TABLE>
<CAPTION>

        Signature                             Title                        Date
        ---------                             -----                        ----
<S>                          <C>                                       <C>
 
                                                                                     
/s/ J. THOMAS PARMETER       Chairman of the Board, President and      July 28, 1998 
- --------------------------   Chief Executive Officer                                 
J. Thomas Parmeter           (Principal Executive Officer)                           
                                                                                     
                                                                                     
/s/ ARON P. STERN            Vice President-Finance and Chief          July 28, 1998 
- --------------------------   Financial Officer (Principal Financial                  
Aron P. Stern                and Accounting Officer)                                 
                                                                                     
                                                                                     
/s/ EDWARD E. DAVID          Director                                  July 28, 1998 
- --------------------------                                                           
Edward E. David                                                                      
                                                                                     
                                                                                     
/s/ GEORGE R. WALKER         Director                                  July 28, 1998 
- --------------------------                                            
George R. Walker                                                      
                                                                      
                                                                                     
/s/ BRENT R. NICKLAS         Director                                  July 28, 1998 
- --------------------------                                                           
Brent R. Nicklas                                                                     
                                                                                     
                                                                                     
/s/ PATRICIA J. CORNELL      Director                                  July 20, 1998 
- --------------------------                                                           
Patricia J. Cornell                                                                  
                                                                                     
                                                                                     
- --------------------------   Director                                  July __, 1998 
J. Paul Jones                                                                        
                                                                                     
                                                                                     
/s/ PHILIP J. DAVIS                                                                  
- --------------------------   Director                                  July 28, 1998 
Philip J. Davis                                                                      
                                                                                     
                                                                                     
/s/ EDWARD J. HARTNETT                                                 July 16, 1998 
- --------------------------   Director                                                
Edward J. Hartnett                                                                   
                                                                                     
                                                                                     
- --------------------------   Director                                  July __, 1998 
Patrick Gerschel
</TABLE>

<PAGE>
 
                                 EXHIBIT INDEX
<TABLE> 
<CAPTION> 

Exhibits
- --------
<S>    <C> 
4.1    1992 Stock Option Plan, as amended.

5.1    Opinion of counsel as to legality of securities
       being registered.

23.1   Consent of Ernst & Young LLP, independent auditors.

23.2   Consent of counsel (included in Exhibit 5.1).

24.1   Power of Attorney (included herein on the signature page).
</TABLE> 

                                      -6-

<PAGE>
 
                                                                     EXHIBIT 4.1




                      PROTEIN POLYMER TECHNOLOGIES, INC.
                      1992 STOCK OPTION PLAN/1//2/           


          1.   PURPOSE.
               ------- 

          The Plan is intended to provide incentive to key employees, directors
and consultants of the Corporation and its Subsidiaries, to encourage
proprietary interest in the Corporation, to encourage such key employees to
remain in the employ of the Corporation and its Subsidiaries or such key
directors and consultants to remain in the service of the Corporation and its
Subsidiaries, and to attract new employees, directors and consultants with
outstanding qualifications.

          2.   DEFINITIONS.  Unless otherwise defined herein or the context
               -----------                                                 
otherwise requires, the capitalized terms used herein shall have the following
meanings:

               (a) "Administrator" shall mean the Board or the Committee, 
                    ------------- 
whichever shall be administering the Plan from time to time in the discretion of
the Board, as described in Section 4 of the Plan.

               (b) "Board" shall mean the Board of Directors of the Corporation.
                    -----                                                       

               (c) "Code" shall mean the Internal Revenue Code of 1986, as
                    ----                                                  
amended.

               (d) "Commission" shall mean the Securities and Exchange
                    ----------                                        
Commission.

               (e) "Committee" shall mean the committee appointed by the Board
                    ---------                                                 
in accordance with Section 4 of the Plan.

               (f) "Common Stock" shall mean the $.01 par value Common Stock 
                    ------------       
of the Corporation and any class of shares into which such Common Stock
hereafter may be converted or reclassified.

               (g) "Corporation" shall mean PROTEIN POLYMER TECHNOLOGIES, INC.,
                    -----------                                                
a Delaware corporation.


/1/   Reflects amendments adopted by the Stock Option Committee as of July 1993
      required by the California Department of Corporations in July 1993.

/2/   Reflects amendment to increase number of shares reserved for issuance
      under the Plan to 1,500,000, approved by the stockholders on May 19, 1998.
 
<PAGE>
 
          (h) "Disability" shall mean a medically determinable physical or
               ----------                                                 
mental impairment which has made an individual incapable of engaging in any
substantial gainful activity.  A condition shall be considered a Disability only
if (i) it can be expected to result in death or has lasted or it can be expected
to last for a continuous period of not less than twelve (12) months, and (ii)
the Administrator, based upon medical evidence, has expressly determined that
Disability exists.

          (i) "Disinterested Person" shall mean a member of the Board who is a
               --------------------                                           
"disinterested person" within the meaning of Rule 16b-3(c)(2)(i) promulgated by
the Commission under the Exchange Act, or any successor rule.

          (j) "Employee"  shall mean an individual who is employed (within the
               --------                                                       
meaning of Section 3401 of the Code and the regulations thereunder) by the
Corporation or a Subsidiary.

          (k) "Exchange Act"  shall mean the Securities Exchange Act of 1934,
               ------------                                            
as amended.

          (l) "Exercise Price" shall mean the price per Share of Common Stock,
               --------------                                                 
determined by the Administrator, at which an Option may be exercised.

          (m) "Fair Market Value" shall mean the value of one (1) Share of
               -----------------                                          
Common Stock, determined as follows:

               (i)  If the Shares are traded on an exchange or over-the-counter
on the National Market System (the "NMS") of the National Association of
Securities Dealers, Inc. Automated Quotation System ("NASDAQ"), (A) if listed on
an exchange, the closing price as reported for composite transactions on the
business day immediately prior to the date of valuation or, if no sale occurred
on that date, then the mean between the closing bid and asked prices on such
exchange on such date, and (B) if traded on the NMS, the last sale price on the
business day immediately prior to the date of valuation or, if no sale occurred
on such date, then the mean between the highest bid and lowest asked prices as
of the close of business on the business day immediately prior to the date of
valuation, as reported in the NASDAQ system;

               (ii)  If the Shares are not traded on an exchange or the NMS but
are otherwise traded over-the-counter, the mean between the highest bid and
lowest asked prices quoted in the NASDAQ system as of the close of business on
the business day immediately prior to the date of valuation or, if on such day
such security is not quoted in the NASDAQ system, the mean between the
representative bid and asked prices on 

                                      -2-
<PAGE>
 
such date in the domestic over-the-counter market as reported by the National
Quotation Bureau, Inc., or any similar successor organization; and

               (iii) If neither clause (i) nor (ii) above applies, the fair
market value as determined by the Administrator in good faith. Such
determination shall be conclusive and binding on all persons.

          (n) "Incentive Stock Option" shall mean an option described in 
              ----------------------                                   
Section 422 of the Code.

          (o) "Nonstatutory Stock Option" shall mean an option that does not
               -------------------------                                    
meet the requirements of Section 422(b) of the Code or is not intended to be an
Incentive Stock Option.

          (p) "Option" shall mean any stock option granted pursuant to the Plan.
               ------     
An Option shall be granted on the date the Administrator takes the necessary
action to approve the grant.  However, if the minutes or appropriate resolutions
of the Administrator provide that an Option is to be granted as of a date in the
future, the date of grant shall be that future date.

          (q) "Option Agreement" shall mean a written stock option agreement 
               ----------------                                   
evidencing a particular Option.

          (r) "Optionee" shall mean a Participant who has received an Option.
              --------                                              

          (s) "Participant" shall have the meaning assigned to it in Section 
               -----------                                          
5(a) hereof.

          (t) "Plan" shall mean this PROTEIN POLYMER TECHNOLOGIES, INC. 1992
               ----                                                         
Stock Option Plan, as it may be amended from time to time.

          (u) "Purchase Price" shall mean the Exercise Price multiplied by the
               --------------                                                 
number of Shares with respect to which an Option is exercised.

          (v) "Retirement" shall mean the voluntary cessation of employment by
               ----------                                                     
an Employee upon the attainment of age sixty-five (65) and the completion of not
less than twenty (20) years of service with the Corporation or a Subsidiary.

          (w) "Section 16 Participant" shall mean a Participant who is (or, in
               ----------------------                                         
the opinion of the Administrator, may be) generally subject to the Section 16
Requirements with respect to purchases and sales of Common Stock or other equity
securities of the Corporation.

                                      -3-
<PAGE>
 
          (x) "Section 16 Requirements" shall mean the those obligations and
               -----------------------                                      
requirements imposed by Sections 16(a) and 16(b) of the Exchange Act and the
rules of the Commission promulgated thereunder.

          (y) "Securities Act" shall mean the Securities Act of 1933, as
               --------------                                           
amended.

          (z) "Share" shall mean one share of Common Stock, adjusted in
               -----                                                   
accordance with Section 10 of the Plan (if applicable).

          (aa) "Subsidiary" shall mean any subsidiary corporation as defined in
                ----------                                          
Section 424(f) of the Code.

     3.   EFFECTIVE DATE.
          -------------- 

          The Plan was adopted by the Board effective December 8, 1992, subject
to the approval of the Corporation's shareholders pursuant to Section 15 hereof.

     4.   ADMINISTRATION.
          -------------- 

          (a) Administrator.  Subject to subsection (c) below, the Plan shall be
              -------------                                                     
administered, in the discretion of the Board from time to time, by the Board or
by a Committee which shall be appointed by the Board.  The Board may from time
to time remove members from, or add members to, the Committee.  Vacancies on the
Committee, however caused, shall be filled by the Board. The Board shall appoint
one of the members of the Committee as Chairman.  The Administrator shall hold
meetings at such times and places as it may determine. Acts of a majority of the
Administrator at which a quorum is present, or acts reduced to or approved in
writing by the unanimous consent of the members of the Administrator, shall be
the valid acts of the Administrator.

          (b) Powers of Administrator.  The Administrator shall from time to
              -----------------------                                       
time at its discretion select the Employees, directors and consultants who are
to be granted Options, determine the number of Shares to be subject to Options
to be granted to each Optionee and designate such Options as Incentive Stock
Options or Nonstatutory Stock Options, except that no Incentive Stock Option may
be granted to a non-Employee director or a non-Employee consultant.  A Committee
or Board member shall in no event participate in any determination relating to
Options held by or to be granted to such Committee or Board member.  The
interpretation and con  struction by the Administrator of any provision of the
Plan or of any Option or Option Agreement shall be final.  No member of the
Administrator shall be liable for any action or 

                                      -4-
<PAGE>
 
determination made in good faith with respect to the Plan or any Option.

          (c) Disinterested Administration.  For so long as the Common Stock
              ----------------------------                                  
remains registered under the Exchange Act and Section 16 Participants are (or,
in the opinion of the Board, may be) eligible to receive Options hereunder, this
Plan shall be administered by a Committee consisting of two or more Board
members who are Disinterested Persons.

     5.   PARTICIPATION.
          ------------- 

          (a)  Eligibility.
               ----------- 

          The Optionee shall be such persons (collec  tively, "Participants";
individually a "Participant") as the Administrator may select from among the
following classes of persons, subject to the terms and conditions of Section
5(b) below:

               (i)  Employees (who may be officers, whether or not they are
directors);

               (ii)  Directors of the Corporation or of a Subsidiary; and

               (iii) Consultants engaged by the Corporation or a Subsidiary.

          Notwithstanding provisions of the first paragraph of this Section
5(a), the Administrator may at any time or from time to time designate one or
more directors as being ineligible for selection as Participants in the Plan for
any period or periods of time.

          (b)  Ten-Percent Shareholders.
               ------------------------ 

          A Participant who owns more than ten percent (10%) of the total
combined voting power of all classes of outstanding stock of the Corporation,
its parent or any of its Subsidiaries shall not be eligible to receive an Option
unless (i) the Exercise Price of the Shares subject to such Option is at least
one hundred ten percent (110%) of the Fair Market Value of such Shares on the
date of grant and (ii) such Option by its terms is not exercisable after the
expiration of five (5) years from the date of grant.

          (c)  Stock Ownership.
               --------------- 

          For purposes of Section 5(b) above, in determining stock ownership, a
Participant shall be considered as owning the stock owned, directly or
indirectly, by or for 

                                      -5-
<PAGE>
 
his or her brothers and sisters, spouse, ancestors and lineal descendants. Stock
owned, directly or indirectly, by or for a corporation, partnership, estate or
trust shall be considered as being owned proportionately by or for its
shareholders, partners or beneficiaries. Stock with respect to which such
Participant holds an Option shall not be counted.

          (d)  Outstanding Stock.
               ----------------- 

          For purposes of Section 5(b) above, "out  standing stock" shall
include all stock actually issued and outstanding immediately after the grant of
the Option to the Optionee.  "Outstanding stock" shall not include shares
authorized for issue under outstanding Options held by the Optionee or by any
other person.

     6.   STOCK.
          ----- 

          The stock subject to Options granted under the Plan shall be Shares of
the Corporation's authorized but unissued or reacquired Common Stock.  The
aggregate number of Shares which may be issued upon exercise of Options under
the Plan shall not exceed 1,500,000.  The number of Shares subject to Options
outstanding at any time shall not exceed the number of Shares remaining
available for issuance under the Plan.  The limitations established by this
Section 6 shall be subject to adjustment in the manner provided in Section 10
hereof upon the occurrence of an event specified in that Section.

     7.   TERMS AND CONDITIONS OF OPTIONS.
          ------------------------------- 

          (a)  Stock Option Agreements.
               ----------------------- 

          Each Option shall be evidenced by an Option Agreement substantially in
the form of Annex A or Annex B (as applicable) to this Plan, or in such other
form as the Administrator shall from time to time determine.  Such Option
Agreements need not be identical but shall comply with and be subject to the
terms and conditions set forth in this Section 7.

          (b)  Nature of Option.
               ---------------- 

               Each Option shall state whether it is an Incentive Stock Option
or a Nonstatutory Stock Option.

          (c)  Optionee's Undertaking.
               ---------------------- 

          Each Optionee shall agree to remain in the employ or service of the
Corporation or a Subsidiary and to render services for a period as shall be
determined by the 

                                      -6-
<PAGE>
 
Administrator, from the date of the granting of the Option, but such agreement
shall not impose upon the Corporation or its Subsidiaries any obligation to
retain the Optionee in their employ or service for any period.

          (d)  Number of Shares.
               ---------------- 

          Each Option shall state the number of Shares to which it pertains and
shall provide for the adjustment thereof in accordance with the provisions of
Section 10 hereof.

          (e)  Exercise Price.
               -------------- 

          Each Option shall state the Exercise Price. The Exercise Price in the
case of any Incentive Stock Option shall not be less than the Fair Market Value
on the date of grant and, in the case of an Incentive Stock Option granted to an
Optionee described in Section 5(b) hereof, shall not be less than one hundred
ten percent (110%) of the Fair Market Value on the date of grant.  The Exercise
Price in the case of any Nonstatutory Stock Option shall not be less than
eighty-five percent (85%) of the Fair Market Value on the date of grant.

          (f) Medium and Time of Payment; Notice.
              ---------------------------------- 

          The Purchase Price shall be payable in full in United States dollars
upon the exercise of the Option; provided, however, that if the applicable
Option Agreement so provides, or the Administrator in its sole discretion
otherwise approves thereof, the Purchase Price may (to the extent permitted by
applicable law) be paid (i) by the surrender of Shares in good form for
transfer, owned by the person exercising the Option and having a Fair Market
Value on the date of exercise equal to the Purchase Price, or in any combination
of cash and Shares, so long as the sum of the cash so paid and the Fair Market
Value of the Shares so surrendered equals the Purchase Price, or (ii) so long as
at least the par value of the Shares being purchased is paid in cash and/or
Shares as above, the balance of the Purchase Price may be paid with a full
recourse promissory note executed by the Optionee. The interest rate and other
terms and conditions of such promissory note shall be determined by the
Administrator.  The Administrator may require that the Optionee grant a security
interest in the Shares being purchased to the Corporation for the purpose of
securing the payment of such promissory note, and the Corporation or its
designee may retain possession of the stock certificate(s) representing such
Shares in order to perfect its security interest.

          In the event the Corporation determines that it is required to
withhold state or Federal income tax as a 

                                      -7-
<PAGE>
 
result of the exercise of an Option, as a condition to the exercise thereof, an
Optionee must make arrangements satisfactory to the Corporation to enable it to
satisfy such withholding requirements before the Optionee shall be permitted to
exercise the Option. Payment of such withholding requirements may be made, in
the discretion of the Administrator, (i) in cash, (ii) by delivery of Shares
registered in the name of the Optionee, or by the Corporation not issuing such
number of Shares subject to the Option, having a Fair Market Value at the time
of exercise equal to the amount to be withheld or (iii) any combination of (i)
and (ii) above.

          The Optionee shall exercise an Option by completing and delivering to
the Corporation, concurrently with the payment of the Purchase Price in the
manner described above, an exercise notice substantially in the form attached as
Annex C hereto, or in such other form as the Administrator shall from time to
time determine.

          (g) Term and Non-Transferability of Options.
              --------------------------------------- 

          Each Option shall state the time or times when all or part thereof
becomes exercisable.  No Option, including Incentive Stock Options, shall be
exercisable after the expiration of ten (10) years from the date it was granted.
During the lifetime of the Optionee, the Option shall be exercisable only by the
Optionee or the Optionee's guardian or legal representative and shall not be
assignable or transferable.  In the event of the Optionee's death, the Option
shall not be transferable by the Optionee other than by will or the laws of
descent and distribution.  Any other attempted alienation, assignment, pledge,
hypothecation, attachment, execution or similar process, whether voluntary or
involuntary, with respect to all or any part of any Option or right thereunder,
shall be null and void and, at the Corporation's option, shall cause all of the
Optionee's rights under the Option to terminate.

          (h) Cessation of Employment (Except by Death, Disability or
              -------------------------------------------------------
Retirement).
- ----------  

          If an Optionee ceases to be an Employee for any reason, other than his
or her death, Disability or Retirement, such Optionee shall have the right,
subject to the restrictions referred to in Section 7(g) above, to exercise the
Option at any time within thirty (30) days after cessation of employment, but,
except as otherwise provided in the applicable Option Agreement, only to the
extent that, at the date of cessation of employment, the Optionee's right to
exercise such Option had accrued pursuant to the terms of the

                                      -8-
<PAGE>
 
applicable Option Agreement and had not previously been exercised.

          For purposes of this Section 7(h), the employment relationship shall
be treated as continuing intact while the Optionee is on military leave, sick
leave or other bona fide leave of absence (to be determined in the sole
discretion of the Administrator).  The foregoing notwithstanding, in the case of
an Incentive Stock Option, employment shall not be deemed to continue beyond the
ninetieth (90th) day after the Optionee ceased active employment, unless the
Optionee's reemployment rights are guaranteed by statute or by contract.

          (i)  Death of Optionee.
               ----------------- 

          If an Optionee dies while a Participant, or after ceasing to be a
Participant but during the period in which he or she could have exercised the
Option under this Section 7, and has not fully exercised the Option, then the
Option may be exercised in full, subject to the restrictions referred to in
Section 7(g) above, at any time within twelve (12) months after the Optionee's
death by the executor or administrator of his or her estate or by any person or
persons who have acquired the Option directly from the Optionee by bequest or
inheritance, but, except as otherwise provided in the applicable Option
Agreement, only to the extent that, at the date or death, the Optionee's right
to exercise such Option had accrued and had not been forfeited pursuant to the
terms of the applicable Option Agreement and had not previously been exercised.

          (j)  Disability of Optionee.
               ---------------------- 

          If an Optionee ceases to be an Employee by reason of Disability, such
Optionee shall have the right, subject to the restrictions referred to in
Section 7(g) above, to exercise the Option at any time within twelve (12) months
after such cessation of employment, but, except as provided in the applicable
Option Agreement, only to the extent that, at the date of such cessation of
employment, the Optionee's right to exercise such Option had accrued pursuant to
the terms of the applicable Option Agreement and had not previously been
exercised.

          (k)  Retirement of Optionee.
               ---------------------- 

          If an Optionee ceases to be an Employee by reason of Retirement, such
Optionee shall have the right, subject to the restrictions referred to in
Section 7(g) above, to exercise the Option at any time within ninety (90) days
after cessation of employment, but only to the extent that, at 

                                      -9-
<PAGE>
 
the date of cessation of employment, the Optionee's right to exercise such
Option had accrued pursuant to the terms of the applicable Option Agreement and
had not previously been exercised.

          (l)  Rights as a Shareholder.
               ----------------------- 

          No one shall have rights as a shareholder with respect to any Shares
covered by an Option until the date of the issuance of a stock certificate for
such Shares.  No adjustment shall be made for dividends (ordinary or extra-
ordinary, whether in cash, securities or other property), distributions or other
rights for which the record date is prior to the date such stock certificate is
issued, except as expressly provided in Section 10 hereof.

          (m) Modification, Extension and Renewal of Options.
              ---------------------------------------------- 

          Within the limitations of the Plan, the Administrator may modify an
Option, accelerate the rate at which an Option may be exercised (including,
without limitation, permitting an Option to be exercised in full without regard
to the installment or vesting provisions of the applicable Option Agreement or
whether the Option is at the time exercisable, to the extent it has not
previously been exercised), extend or renew outstanding Options or accept the
cancellation of outstanding Options (to the extent not previously exercised) for
the granting of new Options in substitution therefor.  The foregoing
notwithstanding, no modification of an Option shall, without the consent of the
Optionee, alter or impair any rights or obligations under any Option previously
granted.

          (n)  Notice of Sale.
               -------------- 

          Until the later of the second anniversary of the grant of any
Incentive Stock Option and the first anniversary of the issuance of any Stock
("incentive stock") pursuant to the exercise of an Incentive Stock Option, the
stock transfer records of the Corporation (whether maintained by it or by any
transfer agent of the Common Stock) shall reflect that any certificates issued
or to be issued representing incentive stock in connection with such exercise
must be registered in the name of the beneficial holder (and not in any "street
name") until transferred to a third party, and that the transfer agent shall
notify the Corporation in a case of any requested transfer of such incentive
stock during that period.  In addition, the certificate or certificates
registered in the name of the beneficial holder representing the incentive stock
issued upon such exercise will bear the following legend during such period:

                                      -10-
<PAGE>
 
               "Solely to assist the issuer of the shares represented by this
               certificate, until the later of the second anniversary of the
               date of grant of the Option under which the certificate was
               originally issued or one year from the date of original issuance
               of the shares represented by the certificate, the Transfer Agent
               will notify the issuer of the shares represented hereby of any
               requested transfer by the original registered holder."

               (o)  Other Provisions.
                    ---------------- 

          An Option Agreement authorized under the Plan may contain such other
provisions not inconsistent with the terms of the Plan (including, without
limitation, restrictions upon the exercise of the Option) as the Administrator
shall deem advisable.

               (p)  Substitution of Options.
                    ----------------------- 

          Notwithstanding any inconsistent provisions or limits under the Plan,
in the event the Corporation acquires (whether by purchase, merger or otherwise)
all or substantially all of outstanding capital stock or assets of another
corporation or of any reorganization or other transaction qualifying under
Section 424 of the Code, the Administrator may, in accordance with the
provisions of that Section, substitute options under the Plan for options under
the plan of the acquired company provided (i) the excess of the aggregate fair
market value of the shares subject to an option immediately after the
substitution over the aggregate option price of such shares is not more than the
similar excess immediately before such substitution and (ii) the new option does
not give persons additional benefits, including any extension of the exercise
period.

          8.   LIMITATION ON ANNUAL AWARDS.
               --------------------------- 

               The aggregate Fair Market Value (determined as of the date an
Option is granted) of the Shares with respect to which Incentive Stock Options
are exercisable for the first time by any Optionee during any calendar year
under the Plan and all other plans maintained by the Corporation, its parent or
its Subsidiaries, shall not exceed $100,000.

                                      -11-
<PAGE>
 
          9.   TERM OF PLAN.
               ------------ 

          Options may be granted pursuant to the Plan until the expiration of
the Plan ten years after the effective date referred to in Section 3.

          10.  EFFECT OF CERTAIN EVENTS.
               ------------------------ 

               (a)  Stock Splits and Dividends.
                    -------------------------- 

          Subject to any required action by shareholders, the number of Shares
covered by the Plan as provided in Section 6 hereof, the number of Shares
covered by each outstanding Option and the Exercise Price thereof shall be
proportionately adjusted for any increase or decrease in the number of issued
Shares resulting from a subdivision or consolidation of Shares or the payment of
a stock dividend (but only if paid in Common Stock) or any other increase or
decrease in the number of issued Shares effected without receipt of
consideration by the Corporation.

               (b) Merger, Sale of Assets, Liquidation.
                   ----------------------------------- 

          Subject to any required action by shareholders, if the Corporation
shall merge with another corporation and the Corporation is the surviving
corporation in such merger and under the terms of such merger the shares of
Common Stock outstanding immediately prior to the merger remain outstanding and
unchanged, each outstanding Option shall continue to apply to the Shares subject
thereto and shall also pertain and apply to any additional securities and other
property, if any, to which a holder of the number of Shares subject to the
Option would have been entitled as a result of the merger.  If the Corporation
sells or disposes of all or substantially all of its assets or merges (other
than a merger of the type described in the immediately preceding sentence) or
consolidates with or into another corporation or entity, this Plan and each
Option shall terminate, but only after each Optionee (or the successor in
interest) has been given the right to exercise any unexpired Option or Options
in full or in part , to the extent that, on the date of such sale, disposition
or merger, the Optionee's right to exercise such Option had accrued pursuant to
the terms of the applicable Option Agreement and had not previously been
exercised.  This right shall be exercisable for the period of twenty (20) days
ending five (5) days before the effective date of the sale, merger, or
consolidation (or such longer period as the Administrator may specify).
Alternatively, in its sole and absolute discretion, the surviving or acquiring
corporation (or the parent company of the surviving or acquiring corporation)
may tender to any Optionee (or successor in interest) a substitute option or
options to purchase shares of 

                                      -12-
<PAGE>
 
the surviving or acquiring corporation (or the parent corporation of the
surviving or acquiring corporation). The substitute option shall contain all
terms and provisions required substantially to preserve the rights and benefits
of all Options then held by the Optionee (or successor in interest) receiving
the substitute option. Any other dissolution or liquidation of the Company shall
cause each Option to terminate.

          At the discretion of the Administrator, an Option exercised in
contemplation of the consummation of the sale of all substantially all of the
assets of the Corporation or a merger (other than a merger of the type described
in the first sentence of the immediately preceding paragraph) or consolidation
of the Corporation with another corporation, may be conditioned upon such sale,
merger or consolidation becoming effective.

               (c)  Adjustment Determination.
                    ------------------------ 

          To the extent that the foregoing adjustments relate to securities of
the Corporation, such adjustments shall be made by the Administrator, whose
determination shall be conclusive and binding on all persons.

               (d)  Limitation on Rights.
                    -------------------- 

          Except as expressly provided in this Section 10, the Optionee shall
have no rights by reason of any sub-division or consolidation of shares of
stock of any class, the payment of any stock dividend or any other increase or
decrease in the number of shares of stock of any class or by reason of any
dissolution, liquidation, merger or consolidation or spin-off of assets or
stock of another corporation, and any issue by the Corporation of shares of
stock of any class, or securities convertible into shares of stock of any class,
shall not affect, and no adjustment by reason thereof shall be made with respect
to, the number or Exercise Price of Shares subject to an Option.  The grant of
an Option pursuant to the Plan shall not affect in any way the right or power of
the Corporation to make adjustments, reclassifications, reorganizations or
changes of its capital or business structure, to merge or consolidate or to
dissolve, liquidate, sell or transfer all or any part of its business or assets.

               (e)  Change in Control.
                    ----------------- 

          In the event of a pending or threatened takeover bid, tender offer or
exchange offer for twenty percent (20%) or more of the outstanding Common Stock
or any other class of stock or securities of the Company (other than a tender
offer or exchange offer made by the Company or any 

                                      -13-
<PAGE>
 
Subsidiary), whether or not deemed a tender offer under applicable federal or
state law, or in the event that any person makes any filing under the Section
13(d) or 14(d) of the Exchange Act with respect to the Company, other than a
filing of a Schedule 13G, the Administrator may in its sole discretion, without
obtaining shareholder approval, take one or more of the following actions to the
extent not inconsistent with other provisions of the Plan:

                 (i)  Pay cash to any or all holders of Options at the then-
                      current market value of the Option Shares in exchange for
                      the cancellation of their outstanding Options; or

                 (ii) Make any other adjustments or amendments to the Plan and
                      outstanding Options necessary to permit the substitution
                      of new Options for outstanding Options.

          11.  SECURITIES LAW REQUIREMENTS.
               --------------------------- 

               (a) Legality of Issuance.
                   -------------------- 

               No Shares shall be issued upon the exercise of any Option unless
and until the Corporation has determined that:

                    (i)   it and the Optionee have taken all actions required to
register the offer and sale of the Shares under the Securities Act, or to
perfect an exemption from the registration requirements thereof;

                    (ii)  any applicable listing requirement of any stock
exchange on which the Common Stock is listed has been satisfied; and

                    (iii)  other applicable provision of state or Federal law
has been satisfied.

               (b) Restrictions on Transfer; Representations of Optionee;
                   ------------------------------------------------------
Legends.
- ------- 

               Regardless of whether the offering and sale of Shares under the
Plan has been registered under the Securities Act or has been registered or
qualified under the securities laws of any state, the Corporation may impose
restrictions upon the sale, pledge or other transfer of such Shares (including
the placement of appropriate legends on stock certificates) if, in the judgment
of the Corporation and its counsel, such restrictions are necessary or desirable
in order 

                                      -14-
<PAGE>
 
to achieve compliance with the provisions of the Securities Act, the securities
laws of any state or any other law. In the event that the sale of Shares under
the Plan is not registered under the Securities Act but an exemption is
available which requires an investment representation or other representation,
each Optionee shall be required to represent that such Shares are being acquired
for investment, and not with a view to the sale or distribution thereof, and to
make such other representations as are deemed necessary or appropriate by the
Corporation and its counsel. Stock certificates evidencing Shares acquired under
the Plan pursuant to an unregistered transaction shall bear the following
restrictive legend and such other restrictive legends as are required or deemed
advisable under the provisions of any applicable law:

          "THE SALE OF THE SECURITIES REPRESENTED HEREBY HAS NOT BEEN REGISTERED
          UNDER THE SECURITIES ACT OF 1933 (THE 'ACT').  ANY TRANSFER OR PLEDGE
          OF SUCH SECURITIES WILL BE INVALID UNLESS A REGISTRATION STATEMENT
          UNDER THE ACT IS IN EFFECT AS TO SUCH TRANSFER OR IN THE OPINION OF
          COUNSEL FOR THE ISSUER SUCH REGISTRATION IS UNNECESSARY IN ORDER FOR
          SUCH TRANSFER OR PLEDGE TO COMPLY WITH THE ACT."

          Any determination by the Corporation and its counsel in connection
with any of the matters set forth in this Section 11 shall be conclusive and
binding on all persons.

               (c) Registration or Qualification of Securities.
                   ------------------------------------------- 

          The Corporation may, but shall not be obligated to, register or
qualify the sale of Shares under the Securities Act or any other applicable law.
The Corporation shall not be obligated to take any affirmative action in order
to cause the sale of Shares under the Plan to comply with any law.

               (d)  Exchange of Certificates.
                    ------------------------ 

          If, in the opinion of the Corporation and its counsel, any legend
placed on a stock certificate representing Shares sold under the Plan is no
longer required, the holder of such certificate shall be entitled to exchange
such certificate for a certificate representing the same number of Shares but
without such legend.

          12. AMENDMENT OF THE PLAN.
              --------------------- 

          The Board may from time to time, with respect to any Shares at the
time not subject to Options, suspend or discontinue the Plan or revise or amend
it in any respect 

                                      -15-
<PAGE>
 
whatsoever except that, without the approval of the Corporation's shareholders,
no such revision or amendment shall:

               (a) Materially increase the benefits accruing to Participants
under the Plan;

               (b) Increase the number of Shares which may be issued under the
Plan;

               (c) Change the designation in Section 5 hereof with respect to
the classes of persons eligible to receive Options; or

               (d) Amend this Section 12 to defeat its purpose.

     13.  EXCHANGE ACT.
          ------------ 

          If the Common Stock is registered under the Exchange Act, the Plan
shall be amended by the Administrator from time to time to the extent necessary
or advisable, in the judgment of the Administrator after having consulted with
Corporation's counsel, to enable Section 16 Participants to obtain the benefits
of such exclusions or exemptions from the Sections 16 Requirements as may be
established by the Commission from time to time by rule, regulation,
administrative order or interpretation (whether such interpretation is made by
the Commission or staff) with respect to (i) the receipt of Options, (ii) the
exercise, modification, extension, cancellation, exchange, termination or
expiration of Options, (iii) the purchase of Common Stock upon the exercise of
Options, (iv) the sale of Common Stock received upon the exercise of Options,
and (v) the administration of this Plan.  Anything in the Plan to the contrary
notwithstanding, such amendments may be made without approval of the
Corporation's shareholders unless and to the extent that, in the judgment of the
Administrator after consulting with the Corporation's counsel, shareholder
approval of such an amendment is a prerequisite to effectuating a desired
exclusion or exemption from the Section 16 Requirements.

          With respect to Section 16 Participants, transactions under this Plan
are intended to comply with all applicable conditions of Rule 16b-3 or its
successors under the Exchange Act.  To the extent any provision of the Plan or
action by the Administrator fails to so comply, it shall be deemed null and
void, to the extent permitted by law and deemed advisable by the Administrator.

                                      -16-
<PAGE>
 
          14.  APPLICATION OF FUNDS.
               -------------------- 

          The proceeds received by the Corporation from the sale of Common Stock
pursuant to the exercise of an Option will be used for general corporate
purposes.

          15.  APPROVAL OF SHAREHOLDERS.
               ------------------------ 

          The Plan shall be subject to approval by the affirmative vote of the
holders of a majority of the Corporation's outstanding shares of capital stock
no later than December 8, 1993.  Prior to such approval, Options may be granted
but shall not be exercisable.  Any amendment described in Section 12 shall also
be subject to approval by the Corporation's shareholders.

          16.  EXECUTION.
               --------- 

          To record the adoption of the Plan by the Board as of December 8,
1992, the Corporation has caused an authorized officer to affix the corporate
name hereto.


                         PROTEIN POLYMER TECHNOLOGIES, INC.


                         By: /s/ J. THOMAS PARMETER
                             ------------------------------
                              J. Thomas Parmeter
                              President

                                      -17-

<PAGE>
 
                                                                     EXHIBIT 5.1
                                                                     -----------

                     PAUL, HASTINGS, JANOFSKY & WALKER LLP
                            555 South Flower Street
                       Los Angeles, California 90071-2371
                            Telephone (213) 683-6000
                            Facsimile (213) 627-0705


                                 July 27, 1998



Protein Polymer Technologies, Inc.
10655 Sorrento Valley Road
San Diego, California 92121

Ladies and Gentlemen:

          We are furnishing this opinion of counsel to Protein Polymer
Technologies, Inc., a Delaware corporation (the "Company"), for filing as
Exhibit 5.1 to the Registration Statement on Form S-8 (the "Registration
Statement") to be filed by the Company with the Securities and Exchange
Commission under the Securities Act of 1933, as amended, relating to the
issuance by the Company of additional options (the "Additional Options")
pursuant to the Company's 1992 Stock Option Plan, as amended (the "Plan"), to
purchase up to an additional 500,000 shares (the "Additional Shares") of the
Company's common stock, $.01 par value per share, upon the exercise of the
Additional Options.

          We have examined the Certificate of Incorporation and Bylaws, each as
amended to date, of the Company, and the originals, or copies certified or
otherwise identified, of records of corporate action of the Company as furnished
to us by the Company, certificates of public officials and of representatives of
the Company, and such other instruments and documents as we deemed necessary, as
a basis for the opinions hereinafter expressed.  In such examination we have
assumed the genuineness of all signatures, the authenticity of all corporate
records and other documents submitted to us and the conformity to original
documents submitted to us as certified or photostatic copies.


<PAGE>
 
Protein Polymer Technologies, Inc.
July 27, 1998
Page 2


          Based upon our examination as aforesaid, and in reliance upon our
examination of such questions of law as we deem relevant under the
circumstances, we are of the opinion that:

          1.   The Additional Options, upon the issuance thereof in the manner
contemplated by the Registration Statement and in accordance with the Plan, will
be validly issued; and

          2.   The Additional Shares, when purchased and issued as described in
the Registration Statement and in accordance with the Plan, will be validly
issued, fully paid and nonassessable.

          We express no opinion with respect to the applicability or effect of
the laws of any jurisdiction other than the Delaware General Corporation Law as
in effect on the date hereof.

          We hereby consent to the filing of this opinion of counsel as Exhibit
5.1 to the Registration Statement.

 

                              Very truly yours,
 
                              /s/ PAUL, HASTINGS, JANOFSKY & WALKER LLP
 



<PAGE>
 
                                                                    Exhibit 23.1

               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS


We consent to the incorporation by reference in the Registration Statement (Form
S-8) pertaining to the 1992 Stock Option Plan of Protein Polymer Technologies,
Inc. of our report dated January 30, 1998, except for Note 9, as to which the
date is April 13, 1998, with respect to the financial statements of Protein
Polymer Technologies, Inc. included in its Annual Report (Form 10-KSB) for the
year ended December 31, 1997, filed with the Securities and Exchange Commission.

 

                                                 /s/ ERNST & YOUNG LLP


San Diego, California
July 20, 1998


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