PENEDERM INC
PRE 14A, 1997-04-22
PHARMACEUTICAL PREPARATIONS
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                         SCHEDULE 14A INFORMATION
       Proxy Statement Pursuant to Section 14(a) of the Securities
                Exchange Act of 1934 (Amendment No. ____)
Filed by the Registrant [X]
Filed by a Party other than the Registrant [  ]
Check  he appropriate box:
[X]       Preliminary Proxy Statement
[  ]      Confidential, for use of the Commission Only (as
permitted by Rule 14a-6(e)(2))
[  ]      Definitive Proxy Statement
[  ]      Definitive Additional Materials
[  ]      Soliciting Material Pursuant to Rule 14a-11(c) or Rule
14a-12

                          PENEDERM INCORPORATED
             (Name of Registrant as Specified in Its Charter)

                          PENEDERM INCORPORATED
 (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):
[X]       No fee required.
[  ]      Fee computed on table below per Exchange Act Rules
   14a-6(i)(1) and 0-11.

    1)  Title of each class of securities to which transaction applies:

        ___________________________________________________________


    2)  Aggregate number of securities to which transaction applies:

        ___________________________________________________________


    3)  Per unit price or other underlying value of transaction
        computed pursuant to Exchange Act Rule 0-11:  *

        ___________________________________________________________
    

     4) Proposed maximum aggregate value of transaction:

        ___________________________________________________________
     

     5) Total fee paid:

        ___________________________________________________________
    

[  ] Fee paid previously with preliminary materials.

[  ] Check box if any part of the fee is offset as provided by
   Exchange Act Rule 0-11(a)(2) and identify the filing for which
   the offsetting fee was paid previously.  Identify the previous
   filing by registration statement number, or the Form or
   Schedule and the date of its filing.

     1) Amount Previously Paid:
     2) Form, Schedule or Registration Statement No.:
     3) Filing Party:
     4) Date Filed:



                     PENEDERM INCORPORATED

                        _______________

            NOTICE OF ANNUAL MEETING OF SHAREHOLDERS

                         June 16, 1997

TO THE SHAREHOLDERS OF PENEDERM INCORPORATED:

     NOTICE IS HEREBY GIVEN that the Annual Meeting of
Shareholders of Penederm Incorporated, a California corporation
(the "Company"), will be held on Monday, June 16, 1997 at 10:00
a.m., Pacific time, at the Westin Hotel - San Francisco Airport,
1 Bayshore Highway, Millbrae, California, for the following
purposes:

          1.   To elect directors to serve for the ensuing year
          and until their successors are elected.

          2.   To approve a change in the Company's state of
          incorporation from California to Delaware through the
          merger of the Company into a newly formed Delaware
          corporation that is a wholly-owned subsidiary of the
          Company.

          3.   To approve an amendment to the Penederm
          Incorporated Equity Incentive Plan to increase by
          400,000 the number of shares reserved for issuance
          under that plan.

          4.   To approve an amendment to the Penederm
          Incorporated Employee Stock Purchase Plan to increase
          by 50,000 the number of shares reserved for issuance
          under that plan.

          5.   To transact such other business as may properly
          come before the meeting or any adjournments thereof.

     The foregoing items of business are more fully described in
the Proxy Statement accompanying this Notice.

     Only shareholders of record at the close of business on
April 25, 1997 (the "Record Date") are entitled to notice of and
to vote at the meeting and any adjournments thereof.

     All shareholders are cordially invited to attend the meeting
in person.  Any shareholder attending the meeting may vote in
person even if such shareholder previously signed and returned a
proxy.


                                   FOR THE BOARD OF DIRECTORS


                                   Lloyd H. Malchow
                                   President and Chief Executive
                                   Officer

Foster City, California
May 8, 1997

     WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE
COMPLETE, DATE AND SIGN THE ENCLOSED PROXY AND MAIL IT PROMPTLY
IN THE ENCLOSED ENVELOPE IN ORDER TO ASSURE REPRESENTATION OF
YOUR SHARES.
                     PENEDERM INCORPORATED

                        _______________

       PROXY STATEMENT FOR ANNUAL MEETING OF SHAREHOLDERS

      The  enclosed Proxy is solicited on behalf of the Board  of
Directors  (the "Board") of Penederm Incorporated (the "Company")
for  use  at  the  Company's Annual Meeting of Shareholders  (the
"Annual Meeting") to be held Monday, June 16, 1997 at 10:00 a.m.,
Pacific time, or at any adjournment or postponement thereof,  for
the  purposes set forth herein and in the accompanying Notice  of
Annual Meeting of Shareholders.  The Annual Meeting will be  held
at  the Westin Hotel - San Francisco Airport, 1 Bayshore Highway,
Millbrae, California.  The Company's principal executive  offices
are located at 320 Lakeside Drive, Foster City, California 94404.
The telephone number at that address is (415) 358-0100.

      These proxy solicitation materials were mailed on or  about
May  8,  1997 to all shareholders entitled to vote at the  Annual
Meeting.

         INFORMATION CONCERNING SOLICITATION AND VOTING

Record Date and Shares Outstanding

     Shareholders of record at the close of business on April 25,
1997  (the "Record Date") are entitled to notice of, and to  vote
at,  the Annual Meeting.  At the Record Date, [_________]  shares
of  the  Company's common stock (the "Common Stock") were issued,
outstanding and entitled to vote at the meeting.

Revocability of Proxies

     Any proxy given pursuant to this solicitation may be revoked
by  the person giving it at any time before its use by delivering
to the Secretary of the Company a written notice of revocation or
a  duly  executed proxy bearing a later date or by attending  the
Annual Meeting and voting in person.

Voting and Solicitation

      Every shareholder voting for the election of directors  may
exercise cumulative voting rights and give one candidate a number
of  votes  equal  to  the  number  of  directors  to  be  elected
multiplied  by  the  number of votes to which  the  shareholder's
shares  are entitled, or distribute such shareholder's  votes  on
the  same  principle among as many candidates as the  shareholder
may  select,  provided that votes cannot be cast  for  more  than
seven  candidates.  However, no shareholder shall be entitled  to
cumulate  votes  unless the candidate's name has been  placed  in
nomination prior to the voting and the shareholder, or any  other
shareholder, has given notice at the meeting prior to the  voting
of  the  intention to cumulate votes.  On all other matters  each
share is entitled to one vote on each proposal or item that comes
before the Annual Meeting.

      The  Company intends to include abstentions and broker non-
votes  as  present or represented for purposes of establishing  a
quorum for the transaction of business.  However, abstentions are
counted  as  votes against a proposal for purposes of determining
whether or not a proposal has been approved, whereas broker  non-
votes  are  not  counted  for purposes of determining  whether  a
proposal has been approved.

      Solicitation of proxies may be made by directors,  officers
and  other  employees  of  the  Company  by  personal  interview,
telephone, facsimile or other method.  No additional compensation
will  be  paid  for  any such services.  Costs  of  solicitation,
including  preparation, assembly, printing and  mailing  of  this
proxy statement, the proxy and any other information furnished to
the  shareholders, will be borne by the Company.  The Company may
reimburse the reasonable charges and expenses of brokerage houses
or  other  nominees or fiduciaries for forwarding proxy materials
to,  and  obtaining authority to execute proxies from, beneficial
owners for whose account they hold shares of Common Stock.


                          PROPOSAL ONE
                     Election of Directors

Nominees

     The By-Laws of the Company provide for a Board consisting of
not  fewer than five nor more than nine directors.  The  size  of
the  Board is set at seven effective as of the date of the Annual
Meeting.   Seven  directors  are to  be  elected  at  the  Annual
Meeting.   Unless  otherwise instructed, the proxy  holders  will
vote  the  proxies received by them for the seven nominees  named
below.   All of the nominees named below are presently  directors
of  the  Company.   In the event that any nominee  is  unable  or
declines  to  serve  as  a director at the  time  of  the  Annual
Meeting,  the proxies will be voted for any nominee who shall  be
designated  by  the present Board to fill the  vacancy.   In  the
event  that  additional  persons are nominated  for  election  as
directors, the proxy holders intend to vote all proxies  received
by  them in such a manner in accordance with cumulative voting as
will  ensure the election of as many of the nominees listed below
as  possible.  In such event, the specific nominees for whom such
votes  will be cumulated will be determined by the proxy holders.
The  term  of  office of each person elected as a  director  will
continue  until the next Annual Meeting of Shareholders or  until
his successor has been elected and qualified.  It is not expected
that  any  nominee will be unable or will decline to serve  as  a
director.

      The  name  of and certain other information regarding  each
nominee is set forth in the table below.

                                                               Director
  Name of Nominee           Age   Position with the Company    Since
                                                               
David E. Collins            62   Chairman of the Board            1994
Lloyd H. Malchow            43   Director, President and          1993
                                 Chief Executive Officer
Robert F. Allnutt           61   Director                         1996
William I. Bergman          65   Director                         1991
Mark J. Gabrielson          41   Director                         1996
Harvey S. Sadow, Ph.D.      74   Director                         1990
Gerald D. Weinstein, M.D.   60   Director                         1987

     There is no family relationship between any of the directors
or executive officers of the Company.

      Mr.  Collins  was appointed Chairman of the  Board  of  the
Company effective January 1, 1997 and served as a director  since
December  1994.   From 1989 to October 1994, Mr. Collins  was  an
Executive  Vice  President  of Schering  Plough  Corporation  and
President   of  its  Healthcare  Products  Division   until   his
retirement.   Prior  to  his  employment  with  Schering   Plough
Corporation  he  worked for Johnson & Johnson  for  26  years  in
various  capacities  and was a member of its executive  committee
from  1982  through 1988.  Mr. Collins has served as Chairman  of
the  Council  on  Family Health and of the Non-Prescription  Drug
Manufacturers Association.  Mr. Collins is a director of  Calypte
Biomedical,  a prescription diagnostic company, Lander,  Inc.,  a
private   consumer  products  company,  MGI  Pharma,   a   public
pharmaceutical company, and Scandipharm, a private pharmaceutical
company.

     Mr. Malchow has served as President, Chief Executive Officer
and a director of the Company since January 1995.  Prior to that,
he  served as the Company's President and Chief Operating Officer
and as a director from May 1993 through January 1995.  He was the
Vice  President  and  General Manager of the  Herbert  Skin  Care
Division of Allergan, Inc. from 1992 to May 1993.  From  1983  to
1991   Mr.   Malchow  held  various  positions,  including   Vice
President,  Sales  of Allergan Medical Optics (formerly  American
Medical  Optics prior to acquisition by Allergan  in  1985)  and,
most  recently, Vice President for Global Development, Skin Care.
He  holds a B.A. from Carroll College, a M.A. from the University
of Maryland and a M.B.A. from Pepperdine University.

      Mr.  Allnutt has been a director of the Company  since  May
1996.   Since  February  1995  Mr.  Allnutt  has  been  a  Senior
Counselor at APCO Associates, a public relations firm.  From 1985
to 1995 he was the Executive Vice President of the Pharmaceutical
Manufacturers  Association  (now  PhRMA),  a  trade   association
representing    multinational   research   based   pharmaceutical
companies. Prior to that, he served for 25 years in a variety  of
positions with the Federal government, including Associate Deputy
Administrator  for NASA, Assistant Administrator  of  the  Energy
Research  and Development Administration, Staff Director  of  the
United  States  Senate  Committee on Aeronautics  and  Space  and
Associate  General  Counsel of the United  States  Commission  on
Government  Procurement.  Mr. Allnutt is  a  director  of  Cortex
Pharmaceuticals,  Inc. a development stage neuroscience  company,
and  Cypros Pharmaceuticals, Inc., a drug and diagnostics product
company.

      Mr.  Bergman has been a director of the Company since March
1991.   Mr.  Bergman served in various positions with Richardson-
Vicks Inc., a personal care products company, from 1952 until  he
retired in 1990.  After Procter & Gamble Co. acquired Richardson-
Vicks Inc., he served as President of Richardson-Vicks U.S.A. and
Vice President of Procter & Gamble Co. until his retirement.  Mr.
Bergman  is  the President and a past Chairman of the Council  on
Family Health and is a past Chairman of the Nonprescription  Drug
Manufacturers Association.  Mr. Bergman is a director  of  ZymeTx
Inc.

      Mr. Gabrielson has been a director of the Company since May
1996.    Since  1995,  he  has  served  as  President  of  Access
Management   Services,  Inc.,  a  medical  technology   sourcing,
transfer  and  corporate development firm.   In  addition,  since
January 1991 Mr. Gabrielson has been a general partner of  Prince
Ventures, L.P., a venture capital management firm that serves  as
the   general  partner  of  Prince  Venture  Partners  III,  L.P.
("Prince").  In  addition, Mr. Gabrielson  is  the  President  of
Pharmaply,  Inc.,  Chairman of Strategic  Marketing  Information,
Inc.,  and Chairman of ONTYX, Inc., all private companies.  Prior
to  joining  Prince,  Mr.  Gabrielson  served  in  a  variety  of
marketing and business positions with SmithKline since July 1978.
Mr.  Gabrielson is also a director of Inhale Therapeutic Systems,
Inc., a drug delivery company.

      Dr. Sadow has been a director of the Company since February
1990.  He was President and Chief Executive Officer of Boehringer
Ingelheim Corporation, a health care company, from 1971  to  1988
and  of  Boehringer Ingelheim Pharmaceuticals, Inc.,  an  ethical
specialty pharmaceutical company, from 1984 to 1988.  In 1988, he
became  Chairman  of  the  Board  of  both  Boehringer  Ingelheim
Corporation and Boehringer Ingelheim Pharmaceuticals.  He retired
as  Chairman of the Board of both companies in 1990 and continued
serving as a director of both companies until 1993.  Dr. Sadow is
also the Chairman of the Board of Cortex Pharmaceuticals, Inc., a
development   stage   neuroscience   company,   and    Cholestech
Corporation,  a medical diagnostics company, and  a  director  of
Anika   Research  Corp.,  a  hyaluronic  acid  research  company,
Houghton  Pharmaceuticals  Inc., a drug  discovery  company,  and
several privately-held health care related companies.  Dr.  Sadow
served as the President of the Connecticut Academy of Science and
Engineering.

      Dr.  Weinstein is a founder of the Company and has  been  a
director  since inception.  He is a co-inventor of the technology
underlying  the  Company's  TopiCare  Delivery  Compounds.    Dr.
Weinstein  has been the Chairman of the Department of Dermatology
at  the  University  of California, Irvine, College  of  Medicine
since 1979.  Dr. Weinstein is a staff member at the University of
California,  Irvine  Medical Center, the Veterans  Administration
Hospital in Long Beach, California and the Irvine Medical Center.
Dr. Weinstein received a B.A. from the University of Pennsylvania
and  a  M.D.  from  the  University  of  Pennsylvania  School  of
Medicine.

Board Meetings and Committees

      The  Board  held a total of six meetings during the  fiscal
year ended December 31, 1996.  No director attended fewer than 75
percent of the aggregate of all meetings of the Board and of  the
committees, if any, upon which such director served.

      The  Audit Committee currently consists of Mr. Collins  and
Dr. Sadow.  The principal functions of the Audit Committee are to
recommend  engagement of the Company's independent  auditors,  to
consult with the Company's auditors concerning the scope  of  the
audit  and  to review with them the results of their examination,
to  review  and  approve any material accounting  policy  changes
affecting  the  Company's operating results  and  to  review  the
Company's financial control procedures and personnel.  The  Audit
Committee held one meeting during fiscal 1996.

      The Compensation Committee currently consists of Dr. Sadow,
Mr.  Bergman  and  Dr.  Weinstein.   The  Compensation  Committee
determines compensation and benefits for the Company's  executive
officers  and  administers the Company's equity incentive  plans.
The  Compensation  Committee, which consists  solely  of  outside
directors    ineligible   to   participate   in   the   Company's
discretionary  employee stock programs, has  sole  and  exclusive
authority to grant stock options to officers and to directors who
are   also   employees  or  consultants  of  the  Company.    The
Compensation Committee held one meeting during fiscal 1996.

     The Board does not have a nominating committee.

Compensation of Directors

     The Company pays directors' fees to each director who is not
an  employee  of, nor an affiliate of investors in, the  Company.
During  fiscal 1996, the individuals who served as such directors
during  that period received a fee of $500 for each Board meeting
attended and $200 for each Board committee meeting attended.  All
non-employee   directors  receive  reimbursement   for   expenses
actually  incurred  in attending meetings of the  Board  and  its
committees.  The Penederm Incorporated 1994 Nonemployee Directors
Stock  Option Plan (the "Directors Plan") provides  that  when  a
person  who  is  not,  and has not been in the  preceding  twelve
months, an officer or an employee of the Company and who has  not
previously  been a member of the Board is elected or appointed  a
member  of the Board, the Company will grant that person  on  the
effective  date  of  such election or appointment  an  option  to
purchase  7,500  shares of the Company's Common  Stock  ("Initial
Grant").   The Directors Plan further provides that at the  first
meeting of the Board immediately following the annual meeting  of
shareholders  of  the Company, the Company  will  grant  to  each
nonemployee  director then in office (other  than  a  nonemployee
director who received an initial option grant under the Directors
Plan  on  or  after  the record date for the annual  meeting)  an
option to purchase 7,500 shares of Common Stock ("Annual Grant").
The  Directors Plan also provides that any non-employee  director
who  did  not receive either an Initial Grant or an Annual  Grant
between the record date for the 1995 annual meeting and the  date
of  the  annual meeting  in 1996 would be  granted  an  option  to
purchase  12,500  shares  in lieu of an  Annual  Grant  in  1996.
Options granted under the Directors Plan vest over one year  from
the  date  of  grant  and  are fully  exercisable  on  the  first
anniversary  of the option grant.  The exercise price  of  option
grants  made under the Directors Plan is equal to the fair market
value of the Common Stock on the date of grant.

                           MANAGEMENT

Security Ownership of Certain Beneficial Owners and Management

     The following table sets forth certain information regarding
beneficial ownership of the Common Stock as of April 25, 1997 (i)
by  each  person who is known by the Company to own  beneficially
more  than  5  percent of the Common Stock, (ii) by each  of  the
Company's  directors,  (iii) by each of the  Company's  executive
officers  named  in  the  Summary Compensation  Table  under  the
caption  "Executive Compensation" below and (iv) by all directors
and executive officers as a group.

                                                               
                                            Number of     Percentage
                                             Shares        of Shares
                                          Beneficially   Beneficially
                 Name                       Owned(1)      Owned(1)(2)
                                                                      
FRANKLIN RESOURCES, INC. (3)                  1,239,500          15.3%
   777 Mariners Island Blvd.
   San Mateo, California 94404
      Charles B. Johnson                      1,239,500          15.3%
      Rupert H. Johnson, Jr.                  1,239,500          15.3%
      Franklin Advisers, Inc.                 1,239,500          15.3%
SAFECO ASSET MANAGEMENT and SAFECO            1,111,467          13.7%
CORPORATION (4)
   Safeco Plaza
   Seattle, Washington 98185
SAFECO COMMON STOCK TRUST (5)                   763,600           9.4%
   Safeco Plaza
   Seattle, Washington 98185
S-E-BANKEN FONDER                               585,100           7.2%
   Jakobsbergsgatan 17
   Stockholm
   Sweden
Mark J. Gabrielson (6)                          341,591           4.2%
Lloyd H. Malchow(7)                             302,000           3.6%
John W. Quigley, Jr., Ph.D.(8)                  152,881           1.9%
William Gutshall(9)                              58,000              *
Edward Ebbers(10)                                49,375              *
Gerald D. Weinstein, M.D.(11)                    45,250              *
Terry L. Opdendyk(12)                            44,061              *
David E. Collins(13)                             32,500              *
William I. Bergman(14)                           17,500              *
Harvey S. Sadow, Ph.D.(15)                       20,000              *
Robert F. Allnutt (16)                            8,500              *
Edgar A. Luce                                    27,827              *
All directors and executive officers as       1,071,658          13.2%
a group (11 persons)(17)
_______________

*    Less than one percent.

 (1) This  table is based upon information supplied by directors,
     officers  and  certain principal shareholders,  as  well  as
     information  included in Securities and Exchange  Commission
     filings made by principal shareholders and other third party
     sources.   Unless  otherwise indicated in the  footnotes  to
     this  table and subject to the community property laws where
     applicable, each of the shareholders named in this table has
     sole  voting and investment power with respect to the shares
     shown.  Percentage  of  ownership is  based  on  [_________]
     shares of Common Stock outstanding as of April 25, 1997.

 (2) Shares  issuable  upon exercise of outstanding  options  are
     considered  outstanding  for  purposes  of  calculating  the
     percentage  of  Common  Stock of  the  person  holding  such
     options,  but  are not deemed outstanding for computing  the
     percentage of ownership of any other person.

 (3) The  shares are reported to be beneficially owned by one  or
     more  investment companies or other managed  accounts  which
     are  advised by Franklin Advisers, Inc. ("FAI") which is  an
     investment  advisory subsidiary of Franklin Resources,  Inc.
     ("FRI").  FAI reports sole voting and dispositive power over
     the  shares.  Charles B. Johnson and Rupert H. Johnson,  Jr.
     (the "Principal Shareholders") report that they each own  in
     excess of 10% of the outstanding common stock of FRI.   FRI,
     the  Principal  Shareholders  and  FAI  disclaim  beneficial
     ownership of the shares.

 (4) SAFECO   Common  Stock  Trust  reports  shared  voting   and
     dispositive power for the shares shown.

 (5) SAFECO  Asset  Management  Company  and  SAFECO  Corporation
     indicate  shared voting and dispositive power  and  disclaim
     beneficial ownership of the shares shown, reporting that the
     shares  are  owned  by registered investment  companies  for
     which they serve as advisor.

 (6) Includes 334,091 shares held by Prince Venture Partners III,
     L.P.  and 7,500 shares issuable upon exercise of outstanding
     options.  Mr.  Gabrielson is the general partner  of  Prince
     Ventures  and the general partner of Prince Venture Partners
     III, L.P.

 (7) Includes   302,000   shares  issuable   upon   exercise   of
     outstanding options; 196,167 of such shares are not  subject
     to repurchase on or after June 25, 1997.

 (8) Includes   120,944   shares  issuable   upon   exercise   of
     outstanding  options; 60,793 of such shares are not  subject
     to repurchase on or after June 25, 1997.

 (9) Includes 58,000 shares issuable upon exercise of outstanding
     options; 41,167 of such shares are not subject to repurchase
     on or after June 25, 1997.

(10) Includes 49,375 shares issuable upon exercise of outstanding
     options; 40,602 of such shares are not subject to repurchase
     on or after June 25, 1997.

(11) Includes 17,500 shares issuable upon exercise of outstanding
     options.

(12) Includes 17,500 shares issuable upon exercise of outstanding
     options.

(13) Includes 17,500 shares issuable upon exercise of outstanding
     options.

(14) Includes 25,000 shares issuable upon exercise of outstanding
     options.

(15) Includes 20,000 shares issuable upon exercise of outstanding
     options.

(16) Includes  7,500 shares issuable upon exercise of outstanding
     options.

(17) Includes   635,319   shares  issuable   upon   exercise   of
     outstanding options; 338,729 of such shares are not  subject
     to repurchase on or after June 25, 1997.


Executive Compensation

      The  following table sets forth the total compensation  for
the  fiscal years ended December 31, 1994, 1995 and 1996  of  the
Chief Executive Officer and each of the executive officers of the
Company  who  served as executive officers at  fiscal  year  end.
None  of  the  named  executive officers earned  any  bonuses  or
compensation for the fiscal years other than as set forth in  the
table or received any restricted stock awards, stock appreciation
rights or long-term incentive plan payouts.

<TABLE>
                   Summary Compensation Table
                                                                         
<CAPTION>
                                                                         
                                                                         
                                                                                           
                                                              Long-Term        
                                       Annual      Annual     Compensa-      Other                                    
                                       Compensa-   Compensa-  tion           Compensation
                             Fiscal    tion        tion       Options     
Name and Principal Position  Year      Salary($)   Bonus($)   (#)            (1)                      
                                       
<S>                           <C>         <C>        <C>       <C>           <C>
                                                                                        
Lloyd H. Malchow              1996        204,555    50,222    155,000       4,492
  President, Chief            1995        195,000    21,840     22,000       4,493
  Executive Officer           1994        178,549    33,469     25,000       3,500
  and Director(2)
                                                                                  
John W. Quigley, Jr., Ph.D.   1996        167,349    16,334     49,500       4,492
  Vice President,             1995        161,340    11,697      9,000       4,493
  Research and                1994        150,785    25,445          -       3,013
  Development
                                                                                  
Edgar A. Luce                 1996        139,055    13,110     18,000       4,170
  Vice President, Finance     1995        127,147    10,807      7,600       3,811
  and Administration,         1994        118,782    17,871      5,000       2,444
  Treasurer and Secretary
  (3)
                                                                                  
Edward Ebbers                 1996        127,109    18,565     37,000       3,812
  Vice President,             1995        112,000     6,272      6,625       3,356
  Sales and Marketing         1994         16,969        --      7,500          --
                                                                                  
William Gutshall              1996        115,664    15,910     27,000       2,314
  Vice President,             1995        109,419     7,440     21,000       2,184
  Operations                  1994        100,875        --      5,000          --
                                
</TABLE>
_______________

(1)  This column includes the value of the shares of Common Stock contributed by
     the  Company to each executive officer's 401(k) account under the  Penederm
     Incorporated 401(k) Plan.  The shares are contributed effective as  of  the
     last trading day of the year and the number of shares contributed was based
     on the closing price of the Common Stock on that date.

(2)  Mr.  Malchow  was appointed Chief Executive Officer of the  Company  as  of
     January 1, 1995.

(3)  Mr. Luce's employment with the Company terminated on December 31, 1996.


       The   following   table   sets   forth  certain   information   regarding
grants    of    stock    options   made   during   the   fiscal    year    ended
December   31,   1996   to  the  executive  officers  named   in   the   Summary
Compensation   Table.    Since   inception,  the   Company   has   not   granted
any stock appreciation rights.

<TABLE>
                           Option Grants in Last Fiscal Year



                                     Individual Grants                     
                                                                                                                                   
                                                                         
<CAPTION>
                                                                          
                                           % of                                     
                                           Total                              Potential Realizable
                                          Options                              Value at Assumed       
                                          Granted                            Annual Rates of Stock      
                                            to                                Price Appreciation      
                               Options   Employees Exercise                   For Option Term (4)      
                               Granted   in Fiscal   Price   Expiration             
            Name               (#)(1)     Year(2)   ($/sh)     Date(3)           5%($)   10%($)
<S>                             <C>         <C>      <C>        <C>          <C>        <C>
                                                                                              
Lloyd H. Malchow                 50,000     12.0 %   $16.875    5/14/06        530,629  1,344,720
                                 30,000      7.1 %    $6.25     8/14/06        117,918    298,826
                                 75,000     18.0 %   $12.375   12/31/06        583,692  1,479,192
                                155,000     37.1 %                           1,232,240  3,122,739
                                                                                              
John W. Quigley, Jr., Ph.D.      18,000      4.3 %   $16.875    5/14/06        191,027    484,099
                                  9,000      2.1 %    $6.25     8/14/06         35,375     89,648
                                 22,500      5.4 %   $12.375   12/31/06        175,108    443,758
                                 49,500     11.8 %                             401,510  1,017,505
                                                                                              
Edgar A. Luce                    12,000      2.9 %   $16.875    5/14/06        127,351    322,733
                                  6,000      1.4 %    $6.25     8/14/06         23,584     59,765
                                 18,000      4.3 %                             150,935    382,498
                                                                                              
Edward Ebbers                    16,000      3.8 %   $13.25     3/4/06         133,326    337,873
                                  6,000      1.5 %    $6.25     8/14/06         23,584     59,765
                                 15,000      3.6 %   $12.375   12/31/06        116,739    295,838
                                 37,000      8.9 %                             273,649    693,477                                  
                                                                                              
William Gutshall                  6,000      1.4 %   $16.875    5/14/06         63,676    161,366
                                  6,000      1.4 %    $6.25     8/14/06         23,583     59,765
                                 15,000      3.6 %   $12.375   12/31/06        116,739    295,838
                                 27,000      6.5 %                             203,998    516,970
                                                                                              
</TABLE>
_______________
(1)  The  options  included  in this table  are  all  immediately
     exercisable,  but the shares issuable upon  option  exercise
     are  subject  to a right of repurchase by the  Company  upon
     employment  termination, which right of  repurchase  expires
     over a period of five years.

(2)  The  total  number  of  options  granted  to  the  Company's
     employees during fiscal year 1996 was 417,793.

(3)  The  options are subject to earlier expiration in the  event
     of the officer's termination of employment with the Company.

(4)  Potential  realizable value is based on an  assumption  that
     the  market  price of the stock appreciates  at  the  stated
     rate, compounded annually, from the date of grant until  the
     end   of  the  ten-year  option  term.   These  values   are
     calculated   based  on  requirements  promulgated   by   the
     Securities  and Exchange Commission and do not  reflect  the
     Company's estimate of future stock price appreciation.


     The following table sets forth certain information regarding
exercises of stock options during the fiscal year ended  December
31,   1996  to  the  executive  officers  named  in  the  Summary
Compensation  Table.   Value realized is  considered  to  be  the
difference between exercise price and market price on the date of
exercise.  Value of unexercised options is considered to  be  the
difference between exercise price and market price of $12.375 per
share on December 31, 1996.

<TABLE>
      Aggregated Option Exercises in Last Fiscal Year and
                 Fiscal Year End Option Values
<CAPTION>
                                                                       Value of
                                                       Number of      Unexercised
                                                      Unexercised    In-the-Money
                                                      Options at      Options at
                                                      Fiscal Year     Fiscal Year
                              Shares                    End(#)          End($)
                             Acquired                                      
                                on         Value     Exercisable/    Exercisable/
                             Exercise    Realized    Unexercisable   Unexercisable
Name                             (#)         ($)          (1)             (1)
<S>                             <C>        <C>           <C>             <C>
                                                                                  
Lloyd H. Malchow                     -           -       302,000/-       844,019/-
John W. Quigley, Jr., Ph.D      22,500     312,750       120,944/-       602,109/-
Edward Ebbers                    1,750      15,531        49,375/-        12,914/-
Edgar A. Luce                        -           -        34,160/-       393,150/-
William Gutshall                     -           -        58,000/-        87,050/-
</TABLE>

_______________


(1)  The  options  included  in this table  are  all  immediately
     exercisable,  but the shares issuable upon  option  exercise
     are  subject  to a right of repurchase by the  Company  upon
     employment  termination, which right of  repurchase  expires
     over a period of time.  At December 31, 1996, the number  of
     shares  subject to repurchase under these options and  their
     value  were as follows: Mr. Malchow -- 216,167 shares having
     a  value of $652,106; Dr. Quigley -- 65,793 shares having  a
     value  of  $173,041; Mr. Ebbers -- 44,701  shares  having  a
     value of $84,836; and Mr. Gutshall -- 45,417 shares having a
     value of $160,074.

      The  Company did not make any awards during the fiscal year
ended December 31, 1996 to any of the executive officers named in
the Summary Compensation Table under any long-term incentive plan
providing  compensation  intended  to  serve  as  incentive   for
performance  to occur over a period longer than one fiscal  year,
excluding stock options.


Report of the Compensation Committee of the Board of Directors

     The Compensation Committee is comprised of three independent
nonemployee directors.  As members of the Compensation Committee,
it  is  our responsibility to determine the most effective  total
executive compensation strategy, based upon the business needs of
the  Company  and  consistent  with shareholders'  interests,  to
administer  the Company's executive compensation plans,  programs
and   policies,   to  monitor  corporate  performance   and   its
relationship to compensation of executive officers, and  to  make
appropriate recommendations concerning matters of compensation.

     Compensation Philosophy

      The  Company  was formed in 1987 as a private  company  and
initially offered Common Stock to the public in 1993.  The  major
goals of the compensation program are to align compensation  with
the  attainment  of  key business objectives and  to  enable  the
Company to attract, retain and reward capable executives who  can
contribute  to  the  continued success of  the  Company.   Equity
participation  and a strong alignment to shareholders'  interests
are  key elements of the Company's compensation philosophy.  Four
key  goals  form  the  basis of compensation  decisions  for  all
employees of the Company:
  
          1.    To  attract  and  retain the  most  highly  qualified
          management and employee team;

          2.    To  pay  competitively compared to  similar  drug
          delivery and biopharmaceutical companies and to provide
          appropriate  reward  opportunities for  achieving  high
          levels of performance compared to similar organizations
          in the marketplace;

          3.    To  emphasize sustained performance  by  aligning
          rewards  with shareholder interests, especially through
          the use of equity participation programs; and

          4.    To  motivate executives and employees to  achieve
          the  Company's annual and long-term business goals  and
          encourage  behavior  toward the  fulfillment  of  those
          objectives.

      As  a  result  of this philosophy, the Company's  executive
compensation  program  consists of base salary,  incentive  stock
options, performance share awards and standard benefits.

      Base  Salary.   The Compensation Committee  recognizes  the
importance  of maintaining compensation practices and  levels  of
compensation competitive with drug delivery and biopharmaceutical
companies  in  comparable  stages of development.   For  external
marketplace  comparison  purposes, a group  of  approximately  72
companies  operating in our industry are utilized for determining
competitive compensation levels.

      Base salary represents the fixed component of the executive
compensation  program.  The Company's philosophy  regarding  base
salaries is conservative, maintaining salaries somewhat below  or
at  approximately the competitive industry median.  Determination
of  base  salary  levels is established on an  annual  review  of
marketplace  competitiveness with similar  biopharmaceutical  and
drug delivery companies, and on individual performance.  Periodic
increases  in  base  salary  relate to  individual  contributions
evaluated  against  established objectives, relative  marketplace
competitiveness  levels, length of service,  and  the  industry's
annual competitive pay practice movement.

     Stock Options.  The Compensation Committee strongly believes
that  one  of  the  important goals of the  compensation  program
should   be   to  provide  key  employees  who  have  significant
responsibility for the management, growth, and future success  of
the  company  with an opportunity to increase their ownership  of
the  Company and potentially gain financially from Company  stock
price  increases.  The interests of shareholders, executives  and
employees should thereby be closely aligned.  Executives and  key
employees  are  eligible to receive stock options  generally  not
more  often  than once a year, giving them the right to  purchase
shares  of Common Stock of the Company in the future at  a  price
equal to fair market value at the date of grant.

      Under  the  Company's  stock option plans,  shares  of  the
Company's Common Stock may be purchased at the fair market  value
on  the date of grant.  All grants must be exercised according to
the   provisions  of  the  Company's  stock  option  plans.   All
outstanding options expire ten years from the date of grant.

      Performance Share Awards.  The Compensation Committee  also
believes  that  a  component  of compensation  of  the  executive
management of the Company should be related to the Company's  and
the    executive's   specific   objectives.    Accordingly,   the
Compensation  Committee granted performance share awards  to  the
executive  officers.  These awards consisted  of  a  bonus  of  a
designated maximum percentage of salary payable in cash or stock,
at  the discretion of the Compensation Committee, based upon  the
achievement  of both the Company's and the individual executive's
targeted objectives.

      Other  Benefits.  The Company's philosophy  is  to  provide
adequate health- and welfare-oriented benefits to executives  and
employees,  but to maintain a highly conservative  position  with
respect to executive benefits.  The Company provides no executive
benefits.

     1996 Compensation for the Chief Executive Officer

      In  1996, Lloyd Malchow was paid a salary of $204,555.  Mr.
Malchow  was  granted a performance share award  in  early  1996,
which  was  paid in cash during the first quarter of 1997,  based
upon the Compensation Committee's evaluation of the attainment of
the  Company's  and Mr. Malchow's stated objectives.   The  total
cash  compensation paid to Mr. Malchow in 1996  is  approximately
the   industry  median  for  chief  executive  officers  of   the
competitive industry comparative group.

     Summary

     The Compensation Committee believes that the compensation of
executives by the Company is appropriate and competitive with the
compensation    provided    by   other    drug    delivery    and
biopharmaceutical companies with which the Company  competes  for
executives   and   employees.    The   Committee   believes   its
compensation  strategy, principles, and  practices  result  in  a
compensation  program tied to shareholder returns and  linked  to
the   achievement  of  annual  and  longer-term   financial   and
operational  results of the Company on behalf  of  the  Company's
shareholders.

     The Compensation Committee of the Board of Directors

               -  William I. Bergman
               -  Dr. Harvey S. Sadow
               -  Dr. Gerald D. Weinstein

Compensation Committee Interlocks and Insider Participation

     The Compensation Committee of the Company currently consists
of Mr. Bergman, Dr. Sadow and Dr. Weinstein.

Certain Relationships and Related Transactions

     Dr. Quigley, Senior Vice President, Research and Development
of  the  Company,  borrowed $125,000 from  the  Company  under  a
promissory  note dated June 15, 1990.  The promissory note  bears
simple  interest at the rate of 8.82 percent per  annum,  payable
quarterly,  and  matures upon the earlier of (i)  demand  by  the
Company,  which  demand may be made at any time  after  June  15,
1992,  or  (ii) termination of Dr. Quigley's employment with  the
Company.  Under an Amended and Restated Pledge Agreement executed
by  Dr.  Quigley and the Company in November 1994, the obligation
under  the  promissory  note  is secured  by  a  portion  of  Dr.
Quigley's options to purchase Common Stock of the Company.

Compliance with Section 16(a) of the Exchange Act

      Section  16(a) of the Securities Exchange Act of  1934,  as
amended  (the  "Exchange Act"), requires the Company's  directors
and executive officers, and persons who own more than ten percent
of a registered class of the Company's equity securities, to file
reports of ownership on Form 3 and changes in ownership on Form 4
or 5 with the Securities and Exchange Commission and the National
Association of Securities Dealers.  Such officers, directors  and
ten  percent  shareholders are also required  by  Securities  and
Exchange  Commission rules to furnish the Company with copies  of
all Section 16(a) forms that they file.

      Based  solely  on  its  review of copies  of  such  reports
received   or  written  representations  from  certain  reporting
persons, the Company believes that, during the fiscal year  ended
December  31,  1996,  there has been no failure  by  any  of  its
officers,  directors or ten percent shareholders  to  file  on  a
timely basis any reports required by Section 16(a) other than the
failure  by Dr. Gerald D. Weinstein to timely file three  reports
on  Form  4,  which  forms  covered four transactions  that  were
therefore not reported on a timely basis.

Stock Price Performance Graph

       The  following  graph  illustrates  a  comparison  of  the
cumulative  total shareholder return (change in stock price  plus
reinvested  dividends)  of the Company's Common  Stock  with  the
Nasdaq  Stock Market Index (U.S.) (the "Nasdaq Composite  Index")
and  the  CRSP  Nasdaq Pharmaceutical Stock  Index  (the  "Nasdaq
Pharmaceutical  Index").   Although the Securities  and  Exchange
Commission  regulations generally require the graph  to  cover  a
five-year period, the graph below covers a 38-month period  since
the  Company's Common Stock has been publicly traded  only  since
November  3, 1993.  The comparisons in the graph are required  by
the  Securities and Exchange Commission and are not  intended  to
forecast or be indicative of possible future performance  of  the
Company's Common Stock.



    [EDGAR REPRESENTATION OF DATA POINTS ON STOCK PRICE PERFORMANCE GRAPH]
<TABLE>
<CAPTION>

                                10/29/93                                     
                                 11/3/93   12/31/93  12/30/94  12/29/95  12/31/96
<S>                                <C>        <C>       <C>       <C>      <C>
Penederm Incorporated              100        100       57        103      112
Nasdaq Composite Index             100        100       97        138      170
Nasdaq Pharmaceutical Index        100        100       75        137      137

</TABLE>

     The comparison assumes a $100 investment on November 3, 1993
(the  date  of  the  Company's initial public  offering)  in  the
Company's  Common Stock and on October 29, 1993 in the securities
comprising   the  Nasdaq  Composite  Index  and  the   securities
comprising the Nasdaq Pharmaceutical Index.


                          PROPOSAL TWO
                  Reincorporation in Delaware

Introduction

     At the Annual Meeting, shareholders will be asked to approve
a  proposal  to change the state of incorporation of the  Company
from  California  to  Delaware.  The Board of Directors  believes
that  the best interests of the Company and its shareholders will
be   served  by  the  proposed  reincorporation.   The   proposal
regarding   reincorporation  and  certain   differences   between
applicable California and Delaware law are summarized below.  The
summary  is  not  complete.  It is qualified in its  entirety  by
reference  to:  (a)  the  Agreement of Merger  (the  "Agreement")
between  the  Company (sometimes referred to as  the  "California
Company") and a newly-formed Delaware corporation named "Penederm
Incorporated"  that is a wholly-owned subsidiary of  the  Company
and   that  would  become  the  new  public  company  after   the
reincorporation (the "Delaware Company"); (b) the Certificate  of
Incorporation   of   the   Delaware   Company   (the    "Delaware
Certificate");  (c)  the  Bylaws of  the  Delaware  Company  (the
"Delaware  Bylaws");  (d) the Articles of  Incorporation  of  the
California Company (the "California Articles"); (e) the Bylaws of
the   California  Company  (the  "California  Bylaws");  (f)  the
Delaware  General  Corporation Law  and  related  case  law  (the
"Delaware  Law")  and (g) the California General Corporation  Law
and  related case law (the "California Law").  The Agreement, the
Delaware Certificate and the Delaware Bylaws are attached to this
proxy  statement  as  Appendices A, B and C,  respectively.   The
California  Articles and the California Bylaws are available  for
inspection at the principal office of the Company and  will  also
be  sent to shareholders on request at a nominal charge to  cover
costs.  Requests should be directed to Michael A. Bates, Penederm
Incorporated,   320  Lakeside  Drive,  Suite  A,   Foster   City,
California 94404, telephone (415) 358-0100.

      If  approved,  the reincorporation will be accomplished  by
merging  the  California Company into the Delaware  Company  (the
"Merger").  After the Merger, the Delaware Company will  continue
to  operate  the business of the Company under the name  Penederm
Incorporated.  The reincorporation will not result in any  change
in  the  business, management, fiscal year, assets,  liabilities,
net worth or location of the headquarters or other facilities  of
the  Company.   The directors elected at the Annual Meeting  will
become  the  directors  of the Delaware  Company.   The  Delaware
Company will continue all stock option and purchase plans of  the
California  Company, as well as the Company's shareholder  rights
plan.   Each option or right to purchase shares of the California
Company's Common Stock under those plans will become an option or
right  to  purchase  the same number of shares  of  the  Delaware
Company's  common stock at the same price and on the  same  terms
and  conditions  as is presently the case.  The Delaware  Company
will also continue all other employee benefit arrangements of the
California Company without change.

     When the Merger becomes effective, each outstanding share of
the  California Company's Common Stock, no par value, will become
one  share of the Delaware Company's common stock, $.01 par value
per  share.   Each  stock  certificate  representing  outstanding
shares  of  the  California  Company's  common  stock  will  then
represent  a  like  number of shares of  the  Delaware  Company's
common  stock.   SHAREHOLDERS NEED NOT  EXCHANGE  THEIR  EXISTING
STOCK   CERTIFICATES  FOR  STOCK  CERTIFICATES  OF  THE  DELAWARE
COMPANY.   However, shareholders may exchange their  certificates
if  they  wish.   The Common Stock of the Company is  listed  for
trading  on the Nasdaq National Market, and after the Merger  the
Delaware Company's Common Stock will continue to be traded on the
Nasdaq National Market under the same symbol ("DERM").

      Under  the California Law, shareholders have the  right  to
exercise  so-called  "dissenters'  rights"  in  connection   with
certain mergers and receive cash for their shares.  However,  the
California  Law does not grant dissenters' rights  in  connection
with mergers such as the Merger.

      APPROVAL  OF  THE PROPOSED REINCORPORATION BY  SHAREHOLDERS
WILL  CONSTITUTE  APPROVAL  OF THE  AGREEMENT,  THE  MERGER,  THE
DELAWARE  CERTIFICATE, THE DELAWARE BYLAWS AND THE ASSUMPTION  BY
THE DELAWARE COMPANY OF THE CALIFORNIA COMPANY'S EMPLOYEE BENEFIT
PLANS AND STOCK OPTION AND PURCHASE PLANS.

     In accordance with California Law, the affirmative vote of a
majority  of  the outstanding shares of Common Stock is  required
for    approval    of   the   reincorporation   proposal.     The
reincorporation  proposal  has been approved  by  the  California
Company's Board of Directors, which unanimously recommends a vote
in  favor  of the proposal.  The Company expects to complete  the
Merger promptly if and after shareholders grant that approval.

     THE BOARD RECOMMENDS THAT SHAREHOLDERS VOTE "FOR" THE
                   REINCORPORATION PROPOSAL.

Principal Reasons for the Proposed Reincorporation

     Well-Established Principles of Corporate Governance.  As the
Company  plans  for  the  future,  the  Board  of  Directors  and
management  believe it essential to be able to  draw  upon  well-
established  principles of corporate governance in  making  legal
and  business  decisions.   The Delaware  Law  includes  numerous
judicial  precedents that address required and permitted  conduct
of  corporations and their boards of directors.   The  California
Law  includes  far  fewer such precedents.  The Company  believes
that   shareholders   will  benefit  from  the   well-established
principles of the Delaware Law.

     Prominence and Flexibility of the Delaware Law.  The Company
also believes that the prominence and flexibility of the Delaware
Law  provide  a  beneficial  foundation  on  which  business  and
corporate  governance  decisions  can  be  based.   The   Company
believes  that  shareholders will benefit from the responsiveness
of  the  Delaware  Law to their needs and those of  the  Company.
Delaware  for  many  years has followed a policy  of  encouraging
incorporation in that state, and, in furtherance of that  policy,
Delaware   has   been  a  leader  in  adopting,  construing   and
implementing comprehensive and flexible corporate laws  that  are
responsive  to  the  legal  and business  needs  of  corporations
organized  under  its  laws.   Many corporations  have  initially
chosen  Delaware for their state of incorporation and many  other
corporations have changed their domicile to Delaware.   Both  the
legislature and courts in Delaware have demonstrated  an  ability
and  willingness to act quickly and effectively to meet  changing
business  needs, and Delaware courts have developed  considerable
expertise in dealing with corporate issues.

     Increased Ability to Attract and Retain Qualified Directors.
The  Company  seeks to continue to attract and  retain  the  most
capable  individuals  available to serve  as  its  directors  and
officers.   The Delaware Law permits corporations  to  limit  the
liability  of  directors  and  provide  indemnification  to   its
directors  and  officers to a somewhat greater  degree  than  has
traditionally been the case under California law.  The  Board  of
Directors  thus believes that reincorporation can be a factor  in
attracting  quality  individuals to  the  Board  and  management,
encouraging existing directors and officers to continue to  serve
in  these  capacities and freeing those persons to make corporate
decisions  on  the merits rather than out of a  desire  to  avoid
personal  liability.   Although  to  date  the  Company  has  not
experienced  difficulty  in attracting  and  retaining  qualified
directors   and  officers,  personal  liability  is  increasingly
expressed  as  a concern.  One reason is that, in November  1996,
California's voters were asked to approve a law that  could  have
expanded  the  liability and further limited the  indemnification
rights  of  directors  and  officers in connection  with  certain
lawsuits  based  on securities laws (Proposition 211).   Although
voters  rejected  that  proposal, it is  possible  that,  in  the
future,  California  will enact laws that  adversely  affect  the
ability of corporations incorporated in that state to attract and
retain quality directors and officers.

Certain Possible Disadvantages

      Despite the unanimous belief of the Board of Directors that
the  proposed  reincorporation is in the best  interests  of  the
California Company and its shareholders, it should be noted  that
some commentators criticize the Delaware Law because it does  not
afford  shareholders  the  same rights  and  protections  as  are
available in, for example, California.  The next section of  this
proxy  statement  discusses certain  of  those  differences.   In
addition,  the  Delaware  Certificate  and  the  Delaware  Bylaws
contain certain provisions that the California Company could have
adopted but has not adopted, which affect the relative rights and
powers   of   shareholders  and  management,  and   shareholders'
participation in corporate decision-making.  These provisions are
discussed in the next section of this proxy statement.

Certain  Differences Between the Charter Documents and Applicable
Laws

      There are certain ways in which, by causing the Company  to
be governed by the Delaware Law, the Delaware Certificate and the
Delaware Bylaws, reincorporation will alter the rights and powers
of   shareholders   and   management,  and   reduce   shareholder
participation  in  certain corporate decisions.   Some  of  these
provisions  have  anti-takeover implications.  In  addition,  the
Delaware Company could implement additional changes in the future
that  further  alter  the rights and powers of  stockholders  and
management.    Some  of  those  changes  could  be  effected   by
amendments   to   the  Delaware  Certificate  after   stockholder
approval.  Others could be effected by amendments to the Delaware
Bylaws  without  stockholder approval.  To reflect  the  language
difference  found in the respective statutes of the  two  states,
the following discussion uses the word "shareholder" with respect
to California and "stockholder" with respect to Delaware.

       Shareholder  Action  by  Written  Consent.   The  Delaware
Certificate provides that stockholders may act only at an  annual
or  special  meeting of stockholders and not by written  consent.
The  California Law permits California corporations to include  a
similar provision in its articles of incorporation.  However, the
California  Articles  do not contain such a  provision,  and  the
California Bylaws specifically provide for shareholders to act by
written consent.  The elimination of the right of shareholders to
act  by  written consent could make more difficult or  discourage
attempts  to  acquire  control of the Company  or  wage  a  proxy
contest.

      Special Shareholder Meetings.  The Delaware Bylaws  provide
that  special meetings of stockholders can be called only by  the
Board  of  Directors, the Chair of the Board or the President  of
the  Delaware  Company.   The  Delaware  Bylaws  also  limit  the
business  permitted  to  be  conducted  at  special  meetings  of
stockholders  to  matters  which the Board  of  Directors  brings
before those meetings.  Under the California Law and as set forth
in  the California Bylaws, a special meeting of shareholders  may
be  called by a corporation's board of directors, the Chairman of
the Board, its President or holders of stock entitled to cast not
less  than  ten  percent of the votes at a meeting (five  percent
under certain circumstances).

     Cumulative Voting.  Cumulative voting enables less than half
the shares that vote for director to elect one or more (but not a
majority  of) directors.  Under non-cumulative voting, a majority
of  the  shares  that  vote elects all the directors.   Both  the
Delaware Law and the California Law permit corporations like  the
Company  to eliminate (or not to grant) rights to elect directors
by   cumulative  voting.   The  California  Bylaws  provide   for
cumulative  voting.   Because the Delaware Certificate  does  not
grant  stockholders  the right to elect directors  by  cumulative
voting,  stockholders  will not have that right  if  the  Company
reincorporates in Delaware.

     Business Combinations.  The Delaware Law subjects to special
stockholder approval requirements certain transactions  involving
a  corporation and significant stockholders.  The California  Law
also  has  provisions  that  address  certain  transactions  with
significant shareholders and with certain other parties as well.

      Under  Section  203  of the Delaware Law  ("Section  203"),
certain  "business combinations" with an "interested stockholder"
are   subject   to  a  three-year  moratorium  unless   specified
conditions  are  met.   The three-year  period  begins  when  the
interested stockholder attains that status.  With exceptions,  an
interested stockholder is a person or group that "owns" at  least
15  percent of the corporation's outstanding voting stock  or  is
affiliated with the corporation and owned at least 15 percent  of
such stock at any time within three years.  A person is deemed to
own  shares,  for this purpose, if that person beneficially  owns
the shares, has a right to acquire them, has a right to vote them
(subject  to  exceptions) or is party to an  agreement  regarding
their acquisition, holding, voting or disposition with the person
that  beneficially  owns them.  "Business combinations"  include,
among  other  transactions: (a) mergers with  or  caused  by  the
interested  stockholder; (b) certain sales or other  dispositions
of  assets to the interested stockholder if the market  value  of
the  assets equals at least ten percent of the total market value
of  the  corporation's consolidated assets or outstanding  stock;
(c)  certain  issuances  of  stock  by  the  corporation  to  the
interested   stockholder   and  (d)  certain   loans,   advances,
guarantees, pledges and other benefits extended to, or  conferred
upon, the interested stockholder.

      The three-year moratorium does not apply if: (a) before the
stockholder  became  an  interested  stockholder,  the  board  of
directors  approved the business combination or  the  transaction
that  caused  the  person  to become an  interested  stockholder;
(b)   the   interested  stockholder  owns  85  percent   of   the
corporation's  voting stock after completion of  the  transaction
that  caused  the stockholder to become an interested stockholder
(certain shares are excluded from this 85 percent calculation) or
(c)  at  the time the person became an interested stockholder  or
after that time, the board approved the business combination  and
the combination is also approved by holders of 66-2/3 percent  of
the  voting  stock  not  owned  by  the  interested  stockholder.
Although  a Delaware corporation may elect not to be governed  by
Section  203, the Delaware Company does not intend to  make  that
election.   Accordingly, Section 203 will apply to  the  Delaware
Company.

     The Company believes that Section 203 may have the effect of
encouraging  potential acquirors to negotiate with  the  Delaware
Company's  Board  of  Directors instead of  launching  a  hostile
acquisition attempt.  Section 203 also has the effect of limiting
the ability of potential acquirors to make a two-tiered bid for a
Delaware  corporation  in  which all stockholders  would  not  be
treated  equally.   Section  203 may deter  potential  unfriendly
offers or other efforts to obtain control of the Delaware Company
that  are  not  approved by its Board of  Directors.   It  could,
therefore,  deprive stockholders of opportunities  to  realize  a
premium on their stock.

      The  California Law requires that holders of  common  stock
receive common stock in a merger of a California corporation with
the  holder  of more than 50 percent but less than 90 percent  of
such common stock, unless all the shareholders approve the merger
or  the California Department of Corporations approves the merger
after  a  hearing as to fairness.  This provision  may  have  the
effect of making a cash-out merger by a majority shareholder more
difficult  to accomplish and deterring a tender offer that  would
precede such a merger.

     The California Law also provides that, with exceptions, when
a  tender  offer or a proposal for a reorganization  or  sale  of
assets   is  made  by  an  "interested  party"  (in  general,   a
controlling  or  managing  party of the  target  corporation),  a
fairness  opinion  regarding  the consideration  to  be  paid  to
shareholders must be delivered to the shareholders.  Furthermore,
if  a  tender  for  shares  or vote  is  sought  pursuant  to  an
interested  party's  proposal and another  party  makes  a  later
proposal at least ten days before the date of acceptance  of  the
interested party's tender or proposal, the shareholders  must  be
informed  of  the  later  offer  and  be  afforded  a  reasonable
opportunity  to  withdraw any vote, consent,  proxy  or  tendered
shares.  The Delaware Law has no comparable provision.

      Shareholder  Rights Plan.  In November 1996, the  Board  of
Directors  adopted a shareholder rights plan for  the  California
Company.   The plan is designed to deter any attempt  to  acquire
the  California Company in a manner or on terms not  approved  by
the  Board of Directors, and to assist the Company's shareholders
in  realizing fair value and equal treatment in the event of  any
takeover  of  the  Company and to protect  the  Company  and  its
shareholders   against  coercive  takeover   tactics.    If   the
reincorporation is completed, the Board of Directors  will  cause
the  Delaware  Company to continue the shareholder  rights  plan.
All  rights  under that plan to purchase shares of the California
Company's  stock would become rights to purchase  shares  of  the
Delaware Company's stock.

     Liability of Directors.  The California Articles provide for
the  elimination of personal monetary liability of  directors  to
the fullest extent permitted by the California Law.  The Delaware
Certificate  provides  for the elimination of  personal  monetary
liability  of  directors to the fullest extent permitted  by  the
Delaware Law.

      The Delaware Law may permit somewhat broader elimination of
such liability than the California Law permits.  The Delaware Law
permits  the  elimination  of personal monetary  liability  of  a
director  to the corporation or its stockholders for breaches  of
the  director's fiduciary duty, other than for: (a)  breaches  of
the director's duty of loyalty; (b) acts or omissions not in good
faith  or  which  involve  intentional misconduct  or  a  knowing
violation of law; (c) unlawful dividends or stock repurchases and
(d)  transactions  from which the director  derived  an  improper
personal benefit.  The California Law permits the elimination  of
personal  monetary liability of a director in actions brought  by
or  in  right  of the corporation for breaches of the  director's
duties  to the corporation and its shareholders, other  than  for
(among   other  things):  (a)  acts  or  omissions  that  involve
intentional misconduct or a knowing or culpable violation of law;
(b) acts or omissions the director believes to be contrary to the
best  interests  of the corporation or its shareholders  or  that
involve  the absence of good faith; (c) transactions  from  which
the  director derived an improper personal benefit; (d)  acts  or
omissions that show a reckless disregard for the director's  duty
to  the corporation or its shareholders in circumstances in which
the  director  was  aware,  or should have  been  aware,  in  the
ordinary course of performing the director's duties, of a risk of
serious  injury  to  the  corporation  or  its  shareholders  and
(e)  acts  or omissions that constitute an unexcused  pattern  of
inattention  that  amounts  to an abdication  of  the  director's
duties to the corporation or its shareholders.

       Indemnification.   California  and  Delaware  both  permit
corporations  to  indemnify their officers, directors,  employees
and   other  agents  under  certain  circumstances.   While   the
indemnification provisions of the California Law and the Delaware
Law are similar, they differ in certain respects.

      The  California Law permits indemnification  for  expenses,
judgments,  fines,  settlements and other  amounts  actually  and
reasonably incurred in connection with third party actions (i.e.,
actions not brought by the corporation or derivatively on  behalf
of the corporation) if the person to be indemnified acted in good
faith  and in a manner that person reasonably believed to  be  in
the  best  interests of the corporation and its shareholders,  as
determined  by a majority vote of a disinterested quorum  of  the
directors,  independent legal counsel (if a quorum of independent
directors is not obtainable), a majority vote of a quorum of  the
shareholders (excluding shares owned by the indemnified party) or
the  court  handling the action.  The Delaware Law  permits  such
indemnification if the person to be indemnified is determined  to
have  acted  in good faith and in a manner that person reasonably
believed  to  be in or not opposed to the best interests  of  the
corporation.   The  Delaware  Law  therefore  appears  to  permit
indemnification even though the indemnified person is  unable  to
demonstrate that his or her conduct was reasonably believed to be
in the best interests of the corporation.

      Both  the  California Law and the Delaware Law also  permit
indemnification   for   expenses  (but  not   judgments,   fines,
settlements or other amounts) actually and reasonably incurred in
actions  brought  directly by the corporation or derivatively  on
the  corporation's  behalf.  However, no such indemnification  is
permitted if the person is adjudged liable to the corporation  in
the  performance  of that person's duties to the corporation  and
its  shareholders,  unless and to the extent a  court  determines
that  indemnification is appropriate.  The California Law further
provides  that the corporation cannot indemnify amounts  paid  in
settling  or otherwise disposing of such an action without  court
approval  or  for expenses incurred in defending such  an  action
which is settled or otherwise disposed of without court approval.
The  Delaware Law allows indemnification of such amounts paid and
expenses incurred in connection with direct or derivative actions
that are settled or otherwise disposed of without court approval.

     The California Law requires indemnification against expenses
actually and reasonably incurred in direct, derivative and  third
party  actions when the individual has successfully defended  the
action   on   the   merits.   The  Delaware  Law  requires   such
indemnification in connection with a successful  defense  on  the
merits  or  otherwise.   Accordingly, the Delaware  Law  requires
indemnification  where  the individual prevails  for  "technical"
reasons such as the bar of an applicable statute of limitations.

      The California Law permits corporations to include in their
articles  of incorporation a provision that extends the scope  of
indemnification  through agreements, bylaws  or  other  corporate
action   beyond   that   specifically  authorized   by   statute.
Similarly,  the  Delaware  Law states  that  the  indemnification
provided by statute is not exclusive of any other indemnification
rights  under  any  by-law, agreement, vote  of  stockholders  or
disinterested  directors,  or otherwise.   This  feature  of  the
Delaware   Law   is  potentially  broader  than  the   California
provision, because the California provision states that any  such
"excess"  indemnification cannot extend  to  conduct  from  which
directors may not be exonerated by a provision in the articles of
incorporation.  The Delaware provision does not contain a similar
requirement.   Both  the California Articles and  the  California
Bylaws, as well as the Delaware Certificate, provide for "excess"
indemnification.

      There  has never been, nor is there any pending or, to  the
Company's  knowledge, threatened litigation or  other  proceeding
involving any of its directors in which the rights of the Company
or  its shareholders would have been or would be affected if  the
Company were already a Delaware corporation as set forth in  this
reincorporation  proposal.   In considering  the  reincorporation
proposal, the Board recognized that the individual directors have
a personal interest in obtaining the benefits of the Delaware Law
and  that  the  expense  to the Company might  be  greater  after
reincorporation  to  the  extent  any  director  or  officer   is
indemnified in circumstances where indemnification would  not  be
available under the California Law.  The Board believes, however,
that  the overall effect of reincorporation is to provide a legal
environment  that enhances the Company's ability to  continue  to
attract and retain high quality directors and officers.

      Single  Class of Directors.  The California Company  has  a
single class of directors and the Delaware Company initially will
have  a  single class of directors.  That means that shareholders
vote to elect all the directors each year.  By contrast, under  a
"classified"  or  "staggered" board, directors are  divided  into
classes  and shareholders vote for the members of only one  class
at  each  annual shareholder meeting.  One possible effect  of  a
classified board is that dissident shareholders cannot as  easily
or  quickly acquire control of the board.  Classified boards  are
permitted  under  both the California Law and the  Delaware  Law;
however, under the California Law if a board is divided into  two
classes the authorized number of directors must be at least  six,
and  if  the  board is divided into three classes the  authorized
number of directors must be at least nine.  The Delaware Law  has
no similar requirement.

      Removal  of  Directors.   Under  the  California  Law,  any
director  or  the  entire board may be removed, with  or  without
cause,  with the approval of a majority of the outstanding shares
entitled  to vote.  However, for corporations like the California
Company that permit cumulative voting, no director may be removed
(unless the entire board is removed) if the number of votes  cast
against  removal would be sufficient to elect the director  under
cumulative voting.

      Under  the  Delaware Law, a director of a corporation  that
does  not have a classified board may be removed with or  without
cause   by   stockholder  vote,  subject   to   limitations   for
corporations  that permit cumulative voting.   A  director  of  a
corporation that has a classified board can be removed  only  for
cause,   unless   its   certificate  of  incorporation   provides
otherwise.   As mentioned, the Delaware Company will not  have  a
classified board.  The Delaware Bylaws provide that directors may
be  removed, with or without cause, at an annual meeting or at  a
special   meeting  of  stockholders  called  for  that   purpose.
Therefore,  after reincorporation, stockholders of  the  Delaware
Company will still be entitled to remove directors without cause.
However,  minority  stockholders who in  some  cases  could  have
blocked  removal  will no longer have that ability,  because  the
Delaware Company will not have cumulative voting.

       Filling  Board  Vacancies.   Under  the  California   Law,
shareholders  may  fill any vacancy on the  board  not  otherwise
filled  by  the  board.  Unless the articles  or  bylaws  provide
otherwise,  the board may fill any vacancy other than one  caused
by  removal of a director.  A vacancy created by removal  may  be
filled   only  by  the  shareholders,  unless  the  corporation's
articles  of incorporation or bylaws also authorize the board  to
fill  such  vacancies.  The California Bylaws do not  permit  the
Board  to fill such vacancies.  Under the Delaware Law, vacancies
and  newly-created directorships may be filled by a  majority  of
the  directors  then  in  office or by the  stockholders,  unless
otherwise provided in the certificate of incorporation or bylaws.
Neither the Delaware Certificate nor the Delaware Bylaws restrict
the  ability of the Delaware Company's stockholders to fill board
vacancies.

       Rights   of  Dissenting  Shareholders.   Under  both   the
California  Law  and  the  Delaware  Law,  a  shareholder  of   a
corporation  that participates in certain major transactions  may
receive  cash equal to the fair value (Delaware) or  fair  market
value  (California)  of the shareholder's  stock  (determined  by
agreement between the shareholder and corporation or by a  court)
in  lieu of the consideration the shareholder would have received
in   the   transaction,  if  the  shareholder   follows   certain
procedures.  The California Law and the Delaware Law differ  with
respect to the circumstances under which such dissenters'  rights
are  available.   The  Delaware Law does not require  dissenters'
rights with respect to: (a) a sale of assets; (b) a merger if the
shares  of the corporation are, for example, traded on the Nasdaq
National Market as the Company's are or (c) a merger in which the
corporation survives and no vote of its stockholders is  required
to  approve  the merger.  The California Law affords  dissenters'
rights in certain sale-of-assets transactions.  In addition,  the
California  exceptions  for dissenters'  rights  in  mergers  are
somewhat  different  than  Delaware's.   Dissenters'  rights  are
available  for  certain  (not all) mergers  involving  California
corporations  whose  shares are traded  on  the  Nasdaq  National
Market.

      Dividends.   Both the California Law and the  Delaware  Law
impose limitations on a corporation's ability to pay dividends or
make  other distributions to shareholders or redeem their  stock.
These  laws  are  intended  to  protect  creditors.   Under   the
California  Law, such distributions generally are limited  either
to  retained  earnings  or  to an amount  that  would  leave  the
corporation with tangible assets equal in value to at  least  125
percent of its liabilities and with current assets at least equal
in  value  to  its  current liabilities (or 125  percent  of  its
current  liabilities  if  the average  pre-tax  and  pre-interest
earnings  for the preceding two fiscal years were less  than  its
average  interest  expense for those  years).   In  general,  the
Delaware Law permits distributions and stock repurchases  out  of
surplus  or, if there is no surplus, out of net profits  for  the
current and preceding fiscal years.

     Certain Loans.  The California Law requires that any loan or
guaranty by the corporation to or for a director or officer  must
be  approved by shareholders, unless extended or granted under  a
plan  approved by shareholders.  Shareholders may also approve  a
bylaw authorizing the corporation's board of directors to approve
loans  or  guaranties to or for officers (including officers  who
are  also  directors), if the board determines that the  loan  or
guaranty  may  reasonably be expected to benefit the corporation.
The  California  Bylaws  contain such  a  provision.   Under  the
Delaware  Law,  a  corporation may make loans to,  guarantee  the
obligations  of  or  otherwise  assist  its  officers  or   other
employees (including any officer or other employee who is also  a
director)  when,  in  the  board's  judgment,  such  action   may
reasonably be expected to benefit the corporation.

     Inspection of Shareholder List.  Both the California Law and
the Delaware Law allow any shareholder to inspect the shareholder
list  for  a  purpose  reasonably related  to  the  shareholder's
interest  as  a  shareholder.  In addition,  the  California  Law
grants an absolute right to inspect and copy the shareholder list
to  holders  of  at least five percent of a corporation's  voting
shares  and  holders of at least one percent of such  shares  who
filed   a   "Schedule  14B"  with  the  Securities  and  Exchange
Commission  relating to the election of directors.  The  Delaware
Law  does not provide an absolute right of inspection.   Lack  of
access  to  shareholder  records,  even  though  unrelated  to  a
shareholder's  interest  as  a  shareholder,  could   result   in
impairment of the shareholder's ability to coordinate support for
or opposition to proposals.

      Shareholder Votes on Certain Transactions and Events.  Both
California and Delaware law generally require that holders of  at
least  a  majority  of  the outstanding  voting  shares  of  both
corporations  participating in a merger approve the  merger.   As
set  forth  above,  the  Delaware Law  contains  a  supermajority
stockholder  voting  requirement (66-2/3 percent  of  the  voting
stock  not  owned  by the "interested stockholder")  for  certain
"business  combinations" including mergers involving  "interested
stockholders".

      The Delaware Law does not require a vote by stockholders of
a  surviving  corporation  in a merger  (unless  the  corporation
provides otherwise in its certificate of incorporation)  if:  (a)
the  merger  agreement does not amend the corporation's  existing
certificate  of  incorporation; (b) each share of  the  surviving
corporation  outstanding before the merger is  unchanged  in  the
merger  and  (c)  the number of shares issued  by  the  surviving
corporation  in  the merger does not exceed  20  percent  of  the
shares outstanding immediately before the merger.  The California
Law  contains  a similar exception from the shareholder  approval
requirement    for   reorganizations   where   the   shareholders
immediately before the reorganization will own equity  securities
immediately after the reorganization constituting more than five-
sixths  of  the  voting  power  of  the  surviving  or  acquiring
corporation.  Both the California Law and the Delaware  Law  also
require  that  a  sale  of  all  or  substantially  all  of   the
corporation's   assets  be  approved  by  a   majority   of   the
corporation's  voting  shares, and the supermajority  stockholder
voting requirement of Section 203 of the Delaware Law applies  to
certain sales of assets by the Delaware Company to an "interested
stockholder".

      With  certain exceptions, the California Law also  requires
that  mergers,  reorganizations,  certain  sales  of  assets  and
similar transactions be approved by a majority vote of each class
of  outstanding  shares.   The Delaware Law  generally  does  not
require class voting, except in certain transactions involving an
amendment  to  the  certificate of incorporation  that  adversely
affects a specific class of shares.  If the Delaware Company ever
issues  shares  of a new class of stock, its holders  would  thus
vote  with  the holders of the common stock unless  the  Delaware
Certificate stated otherwise.

      Size  of  the Board.  The California Articles  establish  a
range   of  five  through  nine  authorized  directors  for   the
California Company and specify that the exact number of directors
will  be  fixed from time to time by board resolution or a  bylaw
adopted  by the Board or the shareholders.  The Board  has  fixed
the  number  of  directors for the California  Company  at  seven
effective on the date of the Annual Meeting.  The Delaware Bylaws
also establish a range of five through nine authorized directors,
with the exact number to be determined by board resolution.   The
initial  fixed  number of authorized directors for  the  Delaware
Company will also be seven.

      Amendment  of  Certificate  or Articles  of  Incorporation.
Under   both  the  Delaware  Law  and  the  California   Law,   a
corporation's  certificate or articles of  incorporation  may  be
amended  only  if the amendment is approved by the board  and  by
holders of a majority of its voting shares.

     Amendment of Bylaws.  The bylaws of a California corporation
may  be  amended  by  shareholders  holding  a  majority  of  the
outstanding  voting  shares or by the  board.   However,  if  the
number  or  range of directors is specified in the  bylaws,  that
provision   can  only  be  changed  with  shareholder   approval.
Shareholders  of  a  California corporation  can  adopt  a  bylaw
limiting  the power of the board to amend the bylaws.  Under  the
Delaware Law, the bylaws may be amended only by the stockholders,
unless  the  corporation's  certificate  of  incorporation   also
confers  that  power  on  the board.   The  Delaware  Certificate
authorizes the Delaware Company's Board of Directors to amend the
Delaware Bylaws.  Accordingly, the Board of the Delaware  Company
will  have  the  ability to change the range  of  the  number  of
directors  without  stockholder  approval.   The  Board  of   the
California Company does not have that ability.

     Interested Director Transactions.  Under the California Law,
contracts  and  other transactions in which  one  or  more  of  a
corporation's  directors have a material financial  interest  are
not  void  or  voidable  because  of  that  interest  if  certain
conditions are met.  Under the Delaware Law, contracts and  other
transactions in which one or more of a corporation's directors or
officers  have  a  financial interest are not  void  or  voidable
because  of  that interest if certain conditions are  met.   With
exceptions,  those  conditions are similar under  California  and
Delaware  law.   Under both laws: (a) either the shareholders  or
the  board  must  approve any such contract or transaction  after
disclosure  of  the  material facts and, in  the  case  of  board
approval,  the  contract or transaction must also  be  "just  and
reasonable"  (in  California)  or "fair"  (in  Delaware)  to  the
corporation  or  (b) the contract or transaction must  have  been
just and reasonable or fair as to the corporation at the time  it
was  approved.  In the latter case, the California Law places the
burden of proof on the interested director.  Under the California
Law,  if  shareholder approval is sought, the interested director
is not entitled to vote the director's shares with respect to the
contract or transaction.  Also under the California Law, if board
approval  is sought, the contract or transaction must be approved
by  a majority vote of a quorum of the directors without counting
the  vote  of  the  interested  directors.   However,  interested
directors  may be counted for purposes of establishing a  quorum.
Under the Delaware Law, if board approval is sought, the contract
or   transaction   must  be  approved  by  a  majority   of   the
disinterested directors even if less than a majority of a quorum.
The  Company is not aware of any plans to propose any transaction
involving directors of the Company.

      Voting  by  Ballot.  The California Law provides  that  the
election  of directors may proceed in the manner set forth  in  a
corporation's  bylaws.   The California Bylaws  provide  for  the
election  of directors by voice vote or by ballot, unless  before
the  voting  begins a shareholder demands voting  by  ballot,  in
which case such vote shall be by ballot.  Under the Delaware Law,
the  right to vote by ballot may be restricted if so provided  in
the  certificate  of  incorporation.   The  Delaware  Certificate
provides that election of directors need not be by written ballot
unless the bylaws so provide.  The Delaware Bylaws do not require
election  of  directors  to be by ballot.   Stockholders  of  the
Delaware  Company  will  therefore  not  be  entitled  to  demand
election  by  written  ballot.  It may be more  difficult  for  a
stockholder  to contest the outcome of a vote that has  not  been
conducted by written ballot.

      Shareholder Derivative Suits.  The California Law  provides
that  a shareholder bringing a derivative action on behalf  of  a
corporation need not have been a shareholder at the time  of  the
transaction to which the action relates if certain tests are met.
In general, under the Delaware Law a shareholder may only bring a
derivative action if the shareholder was such at the time of  the
transaction.    The  California  Law  also  provides   that   the
corporation  or defendant in a derivative suit may seek  a  court
order requiring that the plaintiff shareholder furnish a bond for
security.  The Delaware Law does not have such a feature.

      Dissolution.  Under the California Law, holders  of  shares
having 50 percent or more of the corporation's total voting power
may authorize a corporation's dissolution without board approval.
That  right may not be modified by the articles of incorporation.
Under   the   Delaware  Law,  unless  the  board   approves   the
dissolution,  the  dissolution must be  approved  by  holders  of
shares having 100 percent of the corporation's voting power.

Application of the California Law to Delaware Corporations

      Under  Section 2115 of the California Law, certain  foreign
corporations  (i.e., corporations not organized under  California
law)   are   placed   in  a  special  category   if   they   have
characteristics  of ownership and operation which  indicate  that
they  have  significant contacts with California.  So long  as  a
Delaware  or  other  foreign  corporation  is  in  this   special
category,  and  it  does not qualify for  one  of  the  statutory
exemptions,  it is subject to a number of key provisions  of  the
California   Law  applicable  to  corporations  incorporated   in
California.   Among  the  more  important  provisions  are  those
relating  to  the  election and removal of directors,  cumulative
voting,  prohibition of classified boards of directors, standards
of  liability  and  indemnification of directors,  distributions,
dividends   and  repurchases  of  shares,  shareholder  meetings,
approval  of  certain  corporate  transactions,  dissenters'  and
appraisal rights and inspection of corporate records.

      Exemptions  from Section 2115 are provided for corporations
whose  shares are listed on a major national securities  exchange
or are traded on the Nasdaq National Market and which have 800 or
more shareholders of record.  After the proposed reincorporation,
the  common stock of the Delaware Company will be traded  on  the
Nasdaq  National Market, and held beneficially by more  than  800
stockholders  as  of  the record date of its most  recent  annual
meeting  and,  accordingly, the Delaware Company will  be  exempt
from Section 2115.

Certain Federal Income Tax Considerations

      The  Company has received an opinion of counsel  that,  for
federal income tax purposes, no gain or loss will be recognized
by shareholders as a result of the reincorporation.  In addition,
counsel  has opined that each holder of the California  Company's
shares should have the same basis in the stock  of  the  Delaware
Company  received in the reincorporation as that  holder  had  in
that  holder's shares of the California Company just  before  the
reincorporation.   Moreover, such person's  holding  period  with
respect  to  that stock of the Delaware Company should include  the
period  during which the holder held the corresponding shares  of
the  California Company, assuming the latter were held as capital
assets  at the time of the reincorporation.  Shareholders  should
consult  their  own  tax  advisors  as  to  any  effect  of   the
reincorporation on them under state, local or foreign income  tax
laws.

     The Company has also received an opinion of counsel that the
Company  will  not recognize any gain or loss for federal  income
tax  purposes  as a result of the reincorporation, and  that  the
Delaware Company will succeed, without adjustment, to the federal
income tax attributes of the California Company.


                         PROPOSAL THREE
     Approval of an Amendment to the Penederm Incorporated
                     Equity Incentive Plan

Background

      The Board has approved, subject to shareholder approval, an
amendment to the Penederm Incorporated Equity Incentive Plan (the
"Incentive  Plan")  increasing the  aggregate  number  of  shares
reserved  for  issuance thereunder by 400,000 from  1,312,500  to
1,712,500.

Description of the Proposal

      Currently,  the  Incentive Plan provides that  a  total  of
1,312,500 shares of Common Stock may be issued thereunder.  As of
December  31, 1996, there were 152,933 shares that were currently
available  for  option  grant  under  the  Incentive  Plan.   The
proposed amendment to the Incentive Plan increases the number  of
shares available for issuance under the Incentive Plan by 400,000
shares  to  a total of 1,712,500 shares, in order to ensure  that
there  will be a sufficient reserve of shares to permit the grant
of   further  options  to  existing  and  new  employees  of  and
consultants to the Company.

      The  following table shows the number of shares awarded  to
the  executive  officers named in the Summary Compensation  Table
and  the  identified groups under the Incentive Plan in the  year
ended December 31, 1996.  All options were granted at fair market
value as of the date of grant.


                                                      Number
Name and Position                                    of Shares
                                                     
Lloyd H. Malchow                                     155,000
  President, Chief Executive Officer and Director    

John W. Quigley, Jr., Ph.D.                           49,500
  Vice President, Research and Development           

Edgar A. Luce (1)                                     18,000
  Vice President, Finance and Administration,        
  Treasurer and Secretary

Edward Ebbers                                         37,000
  Vice President, Sales and Marketing                

William Gutshall                                      27,000
  Vice President, Operations                         

All executive officers as a group                    286,500
                                                     
All directors who are executive officers as a group  155,000
                                                     
All directors who are not executive officers as a          0
  group                                                

All employees (other than executive officers) as a   188,793
  group                                                
_______________

(1)  Mr.  Luce's  employment  with  the  Company  terminated   on
     December 31, 1996.


     Description of the Incentive Plan

      The Incentive Plan is intended to strengthen the Company by
providing selected eligible key employees of, and consultants to,
the Company an opportunity to participate in the Company's future
by  offering them an opportunity to acquire stock in the  Company
so  as  to retain, attract and motivate them.  Administration  of
the  Incentive Plan may either by the Board or a Committee of the
Board  (in  either  case, the "Committee").   The  Committee  may
select   key   employees,   including  executive   officers,   or
consultants  to receive awards under the Incentive Plan  and  has
broad  discretion to determine the amount and type of awards  and
terms  and  conditions  of the awards.   Individual  grants  will
generally   be   based  on  a  person's  present  and   potential
contribution to the Company.  Nonemployee directors  and  members
of the Committee are not eligible to participate in the Incentive
Plan.   As  of  March 31, 1997, the Company had approximately  46
employees  eligible to participate in the Incentive Plan.   Since
the  grant  of awards is based upon a determination made  by  the
Committee  after a consideration of various factors, the  Company
currently  cannot determine the nature and amount of  any  awards
that will be granted in the future to any eligible individual  or
group of individuals.  However, the maximum number of shares that
can  be granted under the Incentive Plan to any executive officer
whose  compensation is required to be disclosed pursuant  to  the
rules and regulations under the Exchange Act is 500,000 (generally,
the chief executive officer and the four other most highly 
compensated executive officers).

     Awards may be granted in the form of incentive stock options
("ISOs")  within  the  meaning of Section  422  of  the  Internal
Revenue  Code  of  1986,  as amended ("the "Code"),  nonqualified
stock  options  ("NQOS")  (each ISO  or  NQO,  an  "Option,"  and
collectively, "Options"), restricted stock ("Restricted  Stock"),
stock  purchase  rights ("Stock Purchase Rights") or  performance
shares  ("Performance Shares").  Any award may be granted  either
alone  or in addition to other awards granted under the Incentive
Plan.   The  Committee may condition the grant of the award  upon
the   attainment   of  specified  Company,  group   or   division
performance goals or other criteria, which need not be  the  same
for  all  participants.   No  award  may  be  granted  under  the
Incentive  Plan  on or after September 30, 2003, but  outstanding
awards may extend beyond that date.

      Options.  Options granted under the Incentive Plan  may  be
ISOs  or  NQOs.  The exercise price of ISOs may not be less  than
the  fair market value of the shares subject to the Option on the
date  of  grant.  The exercise price of NQOs must be at least  85
percent  of  the fair market value of the shares subject  to  the
Option  on the date of grant.  The term of any ISO granted  under
the plan may not exceed ten years and the term of any NQO may not
exceed  15  years.  Certain other limitations are also applicable
to ISOs in order to take advantage of the favorable tax treatment
that may be available for ISOs.

      Restricted Stock.  Restricted Stock awards consist of  non-
transferable  shares  of  Common  Stock  of  the  Company.    The
Committee  may provide for the lapse of the transfer restrictions
over  a  period of not more than ten years, or may accelerate  or
waive  such restrictions, in whole or in part, based on  service,
performance or other criteria determined by the Committee.

      Stock Purchase Rights.  Stock Purchase Rights consist of  a
grant  to  purchase Common Stock at a purchase price of not  less
than  85 percent of the fair market value of the Common Stock  on
the  grant date.  Stock Purchase Rights are generally exercisable
for a period of up to 30 days after the grant date.

     Performance Shares.  Performance Shares are shares of Common
Stock  issuable upon the attainment of performance criteria.   At
the  time  of a grant the Committee will determine the number  of
shares  of  Common  Stock  to  be  awarded  at  the  end  of  the
performance  period  if  and  to the extent  that  the  specified
performance  targets  are met.  The consideration  payable  by  a
participant  with respect to a Performance Share  award  will  be
determined by the Committee but may not exceed 50 percent of  the
fair market value of the Common Stock on the date of grant.   The
Committee  will determine the performance period (which currently
is required to be at least one year and not more than six years),
the  performance objectives to be used in granting the awards and
the extent to which awards have been earned.  Performance periods
may  overlap, and participants may be awarded Performance  Shares
having  different performance criteria.  Performance Share awards
may  be  payable  in  cash or stock, at  the  discretion  of  the
Committee, and may bear interest or earn dividends.

      The  consideration payable upon issuance or exercise of  an
award  and any taxes related to an award may be paid in cash,  by
promissory  note  of  the participant, or by  delivery  of  other
property,  including securities of the Company, as authorized  by
the  Committee.   The  Company generally  will  not  receive  any
consideration  upon  the  grant  of  any  awards,  although   the
Incentive  Plan provides that consideration may be  payable  with
respect to the grant of Performance Shares.  Awards generally may
be   exercised   at  any  time  within  three  months   after   a
participant's employment by, or consulting relationship with, the
Company  terminates  (but,  only to  the  extent  exercisable  or
payable  at the time of termination).  If termination is  due  to
the  participant's death, retirement or disability, the award may
be  exercised for two years thereafter.  Shares issued  under  an
award may be subject to a right of repurchase by the Company.  No
award  shall  be  assignable  or  otherwise  transferable  by   a
participant  other  than by will or by the laws  of  descent  and
distribution.

       The  Committee  may  adjust  the  performance  goals   and
measurements applicable to awards.  The Committee also may  waive
in  whole or in part any or all restrictions, conditions, vesting
or  forfeiture  with  respect  to any  award  granted  under  the
Incentive Plan.

     The Board may amend, alter or discontinue the Incentive Plan
or  any  award  at  any  time,  except  that  the  consent  of  a
participant  is  required if the participant's  rights  under  an
outstanding   award  would  be  impaired.    In   addition,   the
shareholders   of  the  Company  must  approve   any   amendment,
alteration  or  discontinuance of the Incentive Plan  that  would
(i)  increase  the  total  number of shares  reserved  under  the
Incentive  Plan, (ii) with respect to provisions solely  as  they
relate to ISOs, to the extent required for the Incentive Plan  to
comply with Section 422 of the Code, (iii) to the extent required
by  other  applicable laws, rules or regulations or (iv)  to  the
extent  that  the  Board  otherwise  concludes  that  shareholder
approval is advisable.

       The  Incentive  Plan  constitutes  an  unfunded  plan  for
incentive and deferred compensation.  The Committee may authorize
the  creation  of trusts or arrangements to meet the  obligations
under the Incentive Plan to deliver stock or make payments.

      In  the  event of a "change in control" of the Company,  as
defined  in the Incentive Plan, the Board may, subject to certain
limitations, accelerate the vesting provisions of awards  or  may
cash out the awards.  A "change in control" is defined to include
the  acquisition of 20 percent or more of the voting power of the
Company's outstanding stock, a proxy solicitation for one or more
directors   without  support  of  the  then  current   Board,   a
dissolution  or  liquidation of the  Company  and  certain  asset
sales,  mergers or reorganizations or other changes in  ownership
of the Company's assets or stock.

Certain Federal Income Tax Consequences

            THE   FOLLOWING   SUMMARY  OF  FEDERAL   INCOME   TAX
CONSEQUENCES  IS  BASED UPON EXISTING STATUTES,  REGULATIONS  AND
INTERPRETATIONS THEREOF.  THE APPLICABLE RULES ARE  COMPLEX,  AND
INCOME  TAX  CONSEQUENCES MAY VARY DEPENDING UPON THE  PARTICULAR
CIRCUMSTANCES  OF  EACH PLAN PARTICIPANT.  THIS  PROXY  STATEMENT
DESCRIBES   FEDERAL   INCOME   TAX   CONSEQUENCES   OF    GENERAL
APPLICABILITY,  BUT  DOES  NOT  PURPORT  TO  DESCRIBE  PARTICULAR
CONSEQUENCES  TO  EACH INDIVIDUAL PLAN PARTICIPANT,  OR  FOREIGN,
STATE OR LOCAL INCOME TAX CONSEQUENCES, WHICH MAY DIFFER FROM THE
UNITED STATES FEDERAL INCOME TAX CONSEQUENCES.

     Incentive Stock Options

           Awards;  Exercise.   ISOs are intended  to  constitute
"incentive  stock options" within the meaning of Section  422  of
the  Code.  ISOs may be granted only to employees of the  Company
(including  directors who are also employees).  The recipient  of
an Option (the "Optionee") does not recognize taxable income upon
either  the grant or exercise of an ISO.  However, the excess  of
the  fair market value of the shares purchased upon exercise over
the Option exercise price (the "Option Spread") is includable  in
the  Optionee's "alternative minimum taxable income" ("AMTI") for
purposes  of  the  alternative minimum tax ("AMT").   The  Option
Spread  is  generally measured on the date  of  exercise  and  is
includable  in  AMTI  in  the year of  exercise.   Special  rules
regarding the time of AMTI inclusion may apply for shares subject
to  a  repurchase right or other "substantial risk of forfeiture"
(including,  in the case of each person subject to the  reporting
requirements  of Section 16 of the Exchange Act, any  limitations
on  resale of shares imposed under Section 16(b) of the  Exchange
Act).   In  addition,  when  stock  is  acquired  subject  to   a
"substantial  risk of forfeiture", an Optionee's  holding  period
for  purposes of determining whether any capital gain or loss  on
sale  is long-term will generally not begin until the restriction
lapses  or the Optionee files an election under Section 83(b)  of
the Code (a "Section 83(b) Election").

          Sale of Option Shares.  If an Optionee holds the shares
purchased under an ISO for at least two years from the  date  the
ISO  was granted and for at least one year from the date the  ISO
was  exercised, any gain from a sale of the shares other than  to
the  Company  should  be taxable as capital  gain.   Under  these
circumstances,  the  Company would  not  be  entitled  to  a  tax
deduction  at the time the ISO was exercised or at the  time  the
stock was sold.  If an Optionee were to dispose of stock acquired
pursuant to an ISO before the end of the required holding periods
(a  "Disqualifying Disposition"), the amount by which the  market
value of the stock at the time the ISO was exercised exceeded the
exercise price (or, if less, the amount of gain realized  on  the
sale)  would be taxable as ordinary income, and the Company would
be  entitled  to a corresponding tax deduction.  Such  income  is
subject  to  information reporting requirements  and  may  become
subject to withholding.  Gain from a Disqualifying Disposition in
excess of the amount required to be recognized as ordinary income
is  capital  gain.  Optionees are required to notify the  Company
immediately  prior  to  making a Disqualifying  Disposition.   If
stock  is  sold to the Company rather than to a third party,  the
sale  may not produce capital gain or loss.  A sale of shares  to
the  Company  will constitute a redemption of such shares,  which
could  be  taxable  as a dividend unless the redemption  is  "not
necessarily equivalent to a dividend" within the meaning  of  the
Code.

           Exercise  With  Stock.  If an Optionee  pays  for  ISO
shares  with  shares of the Company acquired under an  ISO  or  a
qualified   employee  stock  purchase  plan  ("statutory   option
stock"),  the tender of shares is a Disqualifying Disposition  of
the  statutory  option  stock if the above  described  (or  other
applicable) holding periods respecting those shares have not been
satisfied.  If the holding periods with respect to the  statutory
option stock are satisfied, or the shares were not acquired under
a statutory stock option of the Company, then any appreciation in
value  of  the surrendered shares is not taxable upon  surrender.
Special  basis  and holding period rules apply where  previously-
owned stock is used to exercise an ISO.

     Nonqualified Stock Options

           Award; Exercise.  An Optionee is not taxable upon  the
award  of  a NQO.  Federal income tax consequences upon  exercise
will  depend upon whether the shares thereby acquired are subject
to  a  "substantial risk of forfeiture."  If the shares  are  not
subject  to a substantial risk of forfeiture, or if they  are  so
restricted  and the Optionee files a Section 83(b) Election  with
respect to the shares, the Optionee will have ordinary income  at
the  time  of  exercise  measured by the  Option  Spread  on  the
exercise  date.  The Optionee's tax basis in the shares  will  be
their  fair market value on the date of exercise, and the holding
period  for purposes of determining whether capital gain or  loss
upon  sale  is long- or short-term also will begin on that  date.
If the shares are subject to a substantial risk of forfeiture and
no  Section  83(b) Election is filed, the Optionee  will  not  be
taxable upon exercise, but instead will have ordinary income,  on
the  date  the  restrictions lapse, in an  amount  equal  to  the
difference  between  the amount paid for  the  shares  under  the
Option  and their fair market value as of the date of  lapse;  in
addition, the Optionee's holding period will begin on the date of
lapse.

           Whether or not the shares are subject to a substantial
risk  of forfeiture, the amount of ordinary income taxable to  an
Optionee  who  was  an employee at the time of grant  constitutes
"supplemental  wages"  subject  to  withholding  of  income   and
employment  taxes  by  the Company, and the  Company  receives  a
corresponding income tax deduction.

           Sale  of Option Shares.  Upon sale, other than to  the
Company,  of  shares acquired under a NQO, an Optionee  generally
will  recognize  capital  gain or  loss  to  the  extent  of  the
difference between the sale price and the Optionee's tax basis in
the  shares,  which  will  be  long-term  gain  or  loss  if  the
employee's  holding period in the shares is more than  one  year.
If stock is sold to the Company rather than to a third party, the
sale  may not produce capital gain or loss.  A sale of shares  to
the  Company  will constitute a redemption of such shares,  which
could  be  taxable  as a dividend unless the redemption  is  "not
necessarily equivalent to a dividend" within the meaning  of  the
Code.

           Exercise  with  Stock.  If an Optionee tenders  Common
Stock (other than statutory option stock -- see above) to pay all
or  part  of the exercise price of a NQO, the Optionee  will  not
have a taxable gain or deductible loss on the surrendered shares.
Instead, shares acquired upon exercise that are equal in value to
the  fair  market value of the shares surrendered in payment  are
treated  as  if  they  had been substituted for  the  surrendered
shares,  taking as their basis and holding period the  basis  and
holding  period that the Optionee had in the surrendered  shares.
The  additional shares are treated as newly acquired with a  zero
basis.

          If the surrendered shares are statutory option stock as
described above under "Incentive Stock Options", with respect  to
which  the  applicable holding period requirements for  favorable
income  tax  treatment have not expired, then the newly  acquired
shares  substituted for the statutory option shares should remain
subject to the federal income tax rules governing the surrendered
shares,  but the surrender should not constitute a "disqualifying
disposition" of the surrendered stock.



     Restricted Stock

          Upon receipt of Restricted Stock, a recipient generally
has  taxable income in the amount of the excess of the then  fair
market value of the Common Stock over any consideration paid  for
the Common Stock (the "spread").  However, if the Common Stock is
subject  to  a "substantial risk of forfeiture" (described  under
"Incentive Stock Options," above) and the recipient does not make
a  Section 83(b) Election, the recipient will have taxable income
upon lapse of the risk of forfeiture, rather than at receipt,  in
an  amount equal to the spread on the date of lapse.  The taxable
income  constitutes supplemental wages subject to federal  income
and  employment  tax  withholding, and  the  Company  receives  a
corresponding  income  tax  deduction.   Supplemental  wages  are
subject  to  federal income and employment tax.  The consequences
upon  sale or disposition of Restricted Stock generally  are  the
same as for Common Stock acquired under a NQO (see above).

     Performance Shares

          Depending on the exact terms of an award of Performance
Shares,  the Award could be treated for tax purposes in the  same
manner as a Restricted Stock Award, i.e., as receipt of property,
subject to restrictions.

     Stock Purchase Rights

          The tax treatment of Stock Purchase Rights is identical
to that of NQOs, as described above.

      Special Federal Income Tax Consideration Due to Short Swing
Profit Rule

            The  potential  liability  of  a  person  subject  to
Section 16 of the Exchange Act to repay short-swing profits  from
the resale of shares acquired under a Company plan constitutes  a
"substantial risk of forfeiture" within the meaning of the above-
described rules, which is treated as lapsing at such time as  the
potential liability under Section 16 lapses.  Persons subject  to
Section  16 who would be required by Section 16 to repay  profits
from  the immediate resale of stock acquired under a Company plan
should  consider whether to file a Section 83(b) Election at  the
time  they acquire stock under a Company plan in order  to  avoid
deferral  of the date that they are deemed to acquire shares  for
federal income tax purposes.

Proposal

     Shareholders are being asked to approve the amendment to the
Incentive  Plan.   The  affirmative vote  of  the  holders  of  a
majority  of  the outstanding shares of the Common Stock  of  the
Company  represented and voting at the Annual Meeting is required
to adopt the amendment to the Incentive Plan.

Board Recommendation

     THE BOARD RECOMMENDS A VOTE "FOR" APPROVAL OF THE PROPOSAL.



                         PROPOSAL FOUR
     Approval of an Amendment to the Penederm Incorporated
                  Employee Stock Purchase Plan

Background

      The Board has approved, subject to shareholder approval, an
amendment  to  the Penederm Incorporated Employee Stock  Purchase
Plan  (the  "Purchase Plan") increasing the aggregate  number  of
shares reserved for issuance thereunder by 50,000 from 100,000 to
150,000.

Description of the Proposal

      Currently,  the  Purchase Plan provides  that  a  total  of
100,000 shares of Common Stock may be issued thereunder.  A total
of  52,123 shares have been issued under the Purchase Plan.   The
proposed  amendment to the Purchase Plan increases the number  of
shares  available for issuance under the Purchase Plan by  50,000
shares  to  a  total of 150,000 shares, in order to  ensure  that
there  will  be a sufficient reserve of shares to permit  further
purchases by existing and new employees of the Company.

      The following table shows the number of shares purchased by
the  executive  officers named in the Summary Compensation  Table
and  the  identified groups under the Purchase Plan in  the  year
ended  December 31, 1996 and the "Dollar Value" of those  shares.
The  "Dollar  Value" is the difference between  the  fair  market
value  of  the  Common  Stock on the dates of  purchase  and  the
participant's purchase price.

<TABLE>

<CAPTION>
                                                                              
                                                                   Dollar     Number
Name and Position                                                 Value ($)   of Shares
                                                                              
<S>                                                              <C>         <C>
                                                                                                                                   
Lloyd H. Malchow                                                  36,511      3,463
  President, Chief Executive Officer and Director

John W. Quigley, Jr., Ph.D.                                       29,894      2,835
  Vice President, Research and Development

Edgar A. Luce (1)                                                 14,630      2,349
  Vice President, Finance and Administration,
  Treasurer and Secretary

Edward Ebbers                                                     22,586      2,150
  Vice President, Operations

William Gutshall                                                      --          0
  Vice President, Operations

All executive officers as a group                                103,621     10,797

All directors who are executive officers as a group               36,511      3,463

All directors who are not executive officers as a group               --          0

All employees (other than executive officers) as a group          274,971     26,277

</TABLE>
_______________

(1)  Mr.  Luce's  employment  with  the  Company  terminated   on
     December 31, 1996.


Description of Plan

      All  employees, including executive officers and  directors
who  are  employees, customarily employed more than 20 hours  per
week  and  more  than  five months per year by  the  Company  are
eligible  to  participate in the Purchase Plan as  of  the  first
enrollment  date  following employment.  However,  employees  who
hold,  directly or through options, five percent or more  of  the
stock  of  the  Company are not eligible to participate.   As  of
March  31,  1997 approximately 38 employees of the  Company  were
eligible to participate in the Purchase Plan.

      Participants  in  the  Purchase  Plan  may  elect  to  make
contributions  to  the Purchase Plan up to  a  maximum  of  seven
percent  (or  other percentage set by the Board) of compensation.
On the last trading date of each June and December, or such other
dates  as may be established by the Board from time to time,  the
Company  applies the funds then in each participant's account  to
the  purchase of shares.  The cost of each share purchased is  85
percent  of the lower of the closing prices for Common Stock  on:
(i)  the first trading day in the enrollment period in which  the
purchase is made; and (ii) the purchase date.  The length of  the
enrollment  period  may  not  exceed  a  maximum  of  24  months.
Enrollment dates are the first business day of July and  January,
or  such other dates as may be established by the Board from time
to time.  The Board has limited the maximum number of shares that
may  be  purchased by a participant during any enrollment period,
and no participant's right to acquire shares may accrue at a rate
exceeding   $25,000  of  fair  market  value  of   Common   Stock
(determined as of the first trading day in an enrollment  period)
in any calendar year.

      The  Board may administer the Purchase Plan or may delegate
its  authority to a committee.  The Board may amend or  terminate
the  Purchase Plan at any time and may provide for an  adjustment
in  the  purchase  price and the number and  kind  of  securities
available   under  the  Purchase  Plan  in   the   event   of   a
reorganization, recapitalization, stock split, or  other  similar
event.   However,  amendments to increase the  number  of  shares
reserved   for   purchase,  or  that  would   otherwise   require
shareholder  approval in order to comply with federal  securities
regulations,  require  shareholder  approval.   Shares  available
under   the  Purchase  Plan  may  be  either  outstanding  shares
repurchased by the Company or newly issued shares.

Certain Federal Income Tax Consequences

      In  general, participants will not have taxable  income  or
loss under the Purchase Plan until they sell or otherwise dispose
of  shares acquired under the Purchase Plan (or die holding  such
shares).   If  the  shares are held, as of the date  of  sale  or
disposition,  for  longer  than both: (i)  two  years  after  the
beginning  of the enrollment period during which the shares  were
purchased;  and (ii) one year following purchase,  a  participant
will have taxable ordinary income equal to 15 percent of the fair
market  value  of the shares on the first day of  the  enrollment
period  (but  not  in  excess of the  gain  on  the  sale).   Any
additional  gain  from the sale will be long-term  capital  gain.
The  Company  is not entitled to an income tax deduction  if  the
holding periods are satisfied.

      If the shares are disposed of before the expiration of both
of the foregoing holding periods (a "disqualifying disposition"),
a  participant  will have taxable ordinary income  equal  to  the
excess  of  the fair market value of the shares on  the  purchase
date  over the purchase price.  In addition, the participant will
have  taxable  capital gain (or loss) measured by the  difference
between the sale price and the participant's purchase price  plus
the  amount of ordinary income recognized, which gain  (or  loss)
will be long-term if the shares have been held as of the date  of
sale  for  more  than one year.  The Company is  entitled  to  an
income  tax  deduction  equal to the amount  of  ordinary  income
recognized by a participant in a disqualifying disposition.

      Special  rules apply to participants who are  directors  or
officers.

Proposal

     Shareholders are being asked to approve the amendment to the
Purchase Plan.  The affirmative vote of the holders of a majority
of  the  outstanding shares of the Common Stock  of  the  Company
represented and voting at the Annual Meeting is required to adopt
the amendment to the Purchase Plan.

Board Recommendation

     THE BOARD RECOMMENDS A VOTE "FOR" APPROVAL OF THE PROPOSAL.

                      INDEPENDENT AUDITORS

      The  Board  has  selected Ernst & Young LLP as  independent
auditors to audit the financial statements of the Company for the
1997  fiscal  year.  Ernst & Young LLP has been  engaged  as  the
Company's  auditors  since  1995.   Representatives  of  Ernst  &
Young  LLP  are expected to be present at the Annual Meeting  and
will have an opportunity to make a statement if they desire to do
so.   The  representatives of Ernst &  Young  LLP  also  will  be
available to respond to questions raised during the meeting.


                     SHAREHOLDER PROPOSALS

      Proposals of shareholders of the Company which are intended
to  be  presented  at the Company's 1998 meeting of  shareholders
must  be  received by the Secretary of the Company no later  than
January  8,  1998 in order to be included in the proxy soliciting
material relating to that meeting.


                         OTHER MATTERS

     The Company knows of no other matters to be submitted at the
Annual  Meeting.  If any other matters properly come  before  the
Annual  Meeting, it is the intention of the persons named in  the
enclosed proxy to vote the shares they represent as the Board may
recommend.




                                           THE BOARD OF DIRECTORS


Dated: May 8, 1997



                     Penederm Incorporated
PROXY                                                  PROXY
               THIS PROXY IS SOLICITED ON BEHALF
                   OF THE BOARD OF DIRECTORS

     The undersigned hereby appoint(s) Lloyd H. Malchow and
Michael A. Bates, or either of them, each with full power of
substitution, the lawful attorneys and proxies of the undersigned
to vote as designated below, and, in their discretion, upon such
other business as may properly be presented to the meeting, all
of the shares of PENEDERM INCORPORATED which the undersigned
shall be entitled to vote at the Annual Meeting of Shareholders
to be held on June 16, 1997, and at any adjournments or
postponements thereof.

      1.  To elect as directors David E. Collins, Lloyd H.
Malchow, Robert F. Allnutt, William I. Bergman, Mark J.
Gabrielson, Harvey S. Sadow, Ph.D. and Gerald D. Weinstein.

          [ ]  FOR all nominees listed (except as indicated
below)

          [ ]  WITHHOLD AUTHORITY to vote (as to all nominees)

     To withhold authority to vote for any individual nominee,
write that nominee's name on the line provided below:
    _______________________________________________________

      2.  To approve the proposed change in Penederm
Incorporated's state of incorporation from California to
Delaware.

          [ ]  FOR  [  ]  AGAINST  [  ]  ABSTAIN

      3.  To approve the proposed amendment to the Penederm
Incorporated Equity Incentive Plan.

          [ ]  FOR  [  ]  AGAINST  [  ]  ABSTAIN

      4.  To approve the proposed amendment to the Penederm
Incorporated Employee Stock Purchase Plan.

          [ ]  FOR  [  ]  AGAINST  [  ]  ABSTAIN

     This proxy, when properly executed, will be voted in the
manner directed by the undersigned shareholder.  WHEN NO CHOICE
IS INDICATED, THIS PROXY WILL BE VOTED FOR THE NOMINEES OR
PROPOSALS LISTED ABOVE.  The proxy holders in their discretion
may cumulate votes for the election of directors.  This proxy may
be revoked at any time prior to the time it is voted by any means
described in the accompanying Proxy Statement.

                              _______________________________
                                       (Signature)

                              _______________________________
                                       (Signature)

                                                       Please
                              date and sign exactly as name(s)
                              appear(s) hereon.  If shares are
                              held jointly, each holder should
                              sign.  Please give full title and
                              capacity in which signing if not
                              signing as an individual.

                              Dated:  _______________, 1997

PLEASE COMPLETE, DATE AND SIGN THIS PROXY AND MAIL IT PROMPTLY IN
THE ENCLOSED ENVELOPE TO ASSURE REPRESENTATION OF YOUR SHARES.




                                                               APPENDIX A
                  AGREEMENT AND PLAN OF MERGER 
                           BETWEEN
                     PENEDERM INCORPORATION,
                    a California corporation
                             and
                     PENEDERM INCORPORATED,
                     a Delaware corporation
                              

     THIS AGREEMENT AND PLAN OF MERGER (the "Agreement") is
dated as of ______ __, 1997 between Penederm Incorporated, a
California corporation ("Penederm California"), and Penederm
Incorporated, a Delaware corporation ("Penederm Delaware"),
a wholly owned subsidiary of Penederm California.

                         BACKGROUND
                              
      A.  Penederm California is a corporation duly
organized, validly existing and in good standing under the
laws of the State of California and, on the date of this
Agreement, has authority to issue 40,000,000 shares
consisting of 30,000,000 shares of Common Stock, no par
value, and 10,000,000 shares of Preferred Stock, no par
value, of which [_________] shares of Common Stock and no
shares of Preferred Stock are issued and outstanding.

      B.  Penederm Delaware is a corporation duly
organized, validly existing and in good standing under the 
laws of the State of Delaware and, on the date of this Agreement,
has authority to issue 40,000,000 shares, consisting of 
30,000,000 shares of Common Stock, $0.01 par value, and 
10,000,000 shares of Preferred Stock, $0.01 par value, of which
one share of Common Stock is issued and outstanding and owned 
by Penederm California and no shares of Preferred Stock are 
issued and outstanding.

      C.  The Board of Directors of each of Penederm California 
and Penederm Delaware have determined that it is advisable 
and in the best interests of each of such corporations that
Penederm California merge into Penederm Delaware upon the terms 
and subject to the conditions set forth in this Agreement, for 
the purpose of effecting the reincorporation of Penederm California 
in the State of Delaware and have, by resolutions duly adopted, 
approved this Agreement and directed that it be submitted to a 
vote of their respective stockholders and executed by the 
undersigned officers.


      THE PARTIES AGREE AS FOLLOWS:


                   ARTICLE I
                       
                  DEFINITIONS
                       
      When used in this Agreement (and in any Exhibit in 
which such terms are not otherwise defined) the following 
terms shall have the following meanings:

      "California Common Stock" shall mean shares of Common 
Stock, no par value, of Penederm California.

      "California Preferred Stock" shall mean shares of 
Preferred Stock, no par value, of Penederm California.

      "Certificate of Merger" shall mean the Certificate of
Merger of Penederm California into Penederm Delaware to be 
filed with the Secretary of State of the State of Delaware 
in substantially the form attached hereto as Exhibit 2.1.

      "Delaware Common Stock" shall mean shares of Common
Stock, $0.01 par value, of Penederm Delaware.

      "Delaware Preferred Stock" shall mean shares of 
Preferred Stock, $0.01 par value, of Penederm Delaware.

      "Effective Time" shall mean the time when the
Certificate of Merger is filed with the Secretary of State 
of the State of Delaware and the Merger becomes effective.

      "Merger" shall mean the merger of Penederm
California into Penederm Delaware.

      "Shareholders' Meeting" shall mean the annual meeting 
of shareholders of Penederm California to be held on 
June 16, 1997, to approve and adopt this Agreement, among other
things.

      "Surviving Corporation" shall mean Penederm Delaware 
from and after the Effective Time.


                   ARTICLE II
                        
                     MERGER
                        
      2.1 Merger.  At the Effective Time, the
Merger shall become effective under Section 252
of the Delaware General Corporation Law and
Section 1108(d) of the California General
Corporation Law, and Penederm California shall
merge into Penederm Delaware, the separate
existence of Penederm California shall cease and
Penederm Delaware shall continue in existence as
the surviving corporation under the Delaware
General Corporation Law.

       2.2 Filings.  On or prior to the Closing Date,
Penederm California and Penederm Delaware shall cause:

          (a)   an executed counterpart of the
Certificate of Merger to be filed with the
Secretary of State of California; and

          (b)   the Certificate of Merger to be
filed with the Secretary of State of Delaware.
As soon as practicable after the Effective Time,
the Surviving Corporation shall cause the
Certificate of Merger to be filed with the
County Recorder of the county in
which the registered office of Penederm Delaware
in the State of Delaware is located and shall
cause such other local filings to be made as are
required under the laws of the State of
California.

       2.3 Effects of the Merger.  At the
Effective Time:

          (a)   the separate existence of Penederm
California shall cease and Penederm California
shall be merged into Penederm Delaware;

          (b)   the Certificate of Incorporation
of Penederm Delaware shall continue as the
Certificate of Incorporation of the Surviving 
Corporation;

          (c)   the Bylaws of Penederm Delaware shall
continue as the Bylaws of the Surviving Corporation;

          (d)   each officer and director of
Penederm California in office immediately prior
to the Effective Time shall serve in the same
capacity as an officer or director of the Surviving 
Corporation immediately after the Effective Time;

          (e)   each share of California Common
Stock outstanding immediately prior to the
Effective Time shall be converted into one share
of Delaware Common Stock pursuant to Article
III;

          (f)   without further transfer, act,
or deed, the separate existence of Penederm
California shall cease and the Surviving
Corporation shall possess all the rights,
privileges, powers and franchises, and shall be
subject to all the restrictions, disabilities
and duties, of Penederm California; and all
property, real, personal and mixed, and all
debts due to Penederm California on whatever
account, as well as stock subscriptions and all
other things belonging to Penederm California
shall be vested in the Surviving Corporation;
and all property, rights, privileges, powers and
franchises, and all and every other interest of
Penederm California shall be thereafter as
effectually the property of the Surviving
Corporation as they were of Penederm California,
and the title to any real estate vested by deed
or otherwise in Penederm California shall not
revert or be in any way impaired by reason of
the Merger; and all rights of creditors of
Penederm California and all liens upon any
property of Penederm California shall be
preserved unimpaired and all debts, liabilities
and duties of Penederm California shall attach
to the Surviving Corporation and may be enforced
against it to the same extent as if such debts,
liabilities and duties had been incurred or
contracted by it.

      2.4 Further Assurances.  Penederm
California agrees that if, at any time after the
Effective Time, the Surviving Corporation shall
consider or be advised that any further deeds,
assignments or assurances are necessary or
desirable to vest, perfect or confirm in the
Surviving Corporation title to any property or
rights of Penederm California, the Surviving
Corporation and its officers and directors may
execute and deliver all such deeds, assignments
and assurances and do all other things necessary
or desirable to vest, perfect or confirm title
to such property or rights in the Surviving
Corporation and otherwise to carry out the
purposes of this Agreement, in the name of
Penederm California or otherwise.


                         ARTICLE III

                     CONVERSION OF STOCK

         3.1 Conversion of Stock.  At the
Effective Time, the stock of Penederm California shall be
converted into stock of Penederm Delaware, as
follows:

          (a)   each share of California Common
Stock issued and outstanding immediately prior
to the Effective Time shall, by virtue of the
Merger and without any action on the part of the
holder thereof, be converted into one share of
Delaware Common Stock; and

          (b)   each share of Delaware Common
Stock issued and outstanding immediately prior
to the Effective Time shall be canceled and 
retired and no stock shall be issued in the 
Merger in respect thereof.

       3.2 Stock Certificates.  At and after the
Effective Time, all of the outstanding certificates 
which immediately prior to the Effective Time
represented shares of California Common Stock
shall be deemed for all purposes to evidence
ownership of, and to represent, shares of
Delaware Common Stock into which the shares of California 
Common Stock formerly represented by such certificates
have been converted as provided in this
Agreement. The registered owner on the books and
records of Penederm Delaware or its transfer
agent of any outstanding stock certificate
shall, until such certificate shall have been
surrendered for transfer or otherwise accounted
for to Penederm Delaware or its transfer agents,
have and be entitled to exercise any voting and
other rights with respect to, and to receive any
dividends and other distributions upon, the
shares of Delaware Common Stock evidenced by
such outstanding certificate as provided above.

       3.3 Stock Options.  Each right or
option to purchase shares of California Common
Stock granted under the Penederm Incorporated
Equity Incentive Plan, the Penederm Incorporated
1994 Nonemployee Directors Stock Option Plan,
the Penederm Incorporated Employee Stock
Purchase Plan, the Penederm Incorporated
Employee Stock Option Plan and the Penederm
Incorporated Consultant Stock Option Plan
(collectively, the "Plans") which is outstanding
immediately prior to the Effective Time, shall
by virtue of the Merger and without any action
on the part of the holder thereof, be converted
into and become an option to purchase the same
number of shares of Delaware Common Stock at the
same option price per share, and upon the same
terms and subject to the same conditions as in
effect at the Effective Time.  The same number
of shares of Delaware Common Stock shall be
reserved for purposes of said Plans as is equal
to the number of shares of California Common
Stock so reserved as of the Effective Time.  As
of the Effective Time, Penederm Delaware hereby
assumes the Plans and all obligations of
Penederm California under the Plans including
the outstanding options or awards or portions
thereof granted pursuant to the Plans.

       3.4 Rights Agreement.  Each right to purchase
shares of California Common Stock outstanding under the
Rights Agreement, dated November 20, 1996,
between Penederm California and ChaseMellon
Shareholder Services, LLC (the "Rights
Agreement") shall become a right to purchase the
same number of shares of Delaware Common Stock
at the same price and on the same terms and
conditions as set forth in the Rights Agreement
and Penederm Delaware shall assume all rights
and obligations of Penederm California under the
Rights Agreement immediately as of the Effective
Time.

      3.5 Validity of Delaware Common Stock.
All shares of Delaware Common Stock into which
California Common Stock are to be converted
pursuant to the Merger shall not be subject to
any statutory or contractual preemptive rights,
shall be validly issued, fully paid and
nonassessable and shall be issued in full
satisfaction of all rights pertaining to such
California Common Stock.

       3.6 Rights of Former Holders.  From and after
the Effective Time, no holder of certificates which
evidenced California Common Stock immediately
prior to the Effective Time shall have any rights 
with respect to the shares formerly evidenced by 
those certificates, other than to receive the shares 
of Delaware Common Stock into which such California 
Common Stock shall have been converted pursuant to 
the Merger. 


                    ARTICLE IV
                         
                     GENERAL

       4.1 Consents.  Each of Penederm California and
Penederm Delaware shall use its best efforts to obtain
the consent and approval of each person (other than 
shareholders of Penederm California in their capacities 
as such) whose consent or approval shall be required in 
order to permit consummation of the Merger.

       4.2 Governmental Authorizations.  Each of
Penederm California and Penederm Delaware shall
cooperate in filing any necessary reports or other 
documents with any federal, state, local or foreign 
authorities having jurisdiction with respect to the 
Merger.

       4.3 Waiver and Amendment.  This Agreement may be
amended by action of the Board of Directors of each
of Penederm California and Penederm Delaware without 
action by the stockholders of the parties, except that 
(a) any amendment to Section 3.1, (b) any amendment changing 
the terms, rights, powers or preferences of the Delaware 
Common Stock, or (c) any amendment altering any terms of 
this Agreement if such alteration would adversely affect 
the holders of California Common Stock or Delaware Common 
Stock must be approved by a majority of the voting
power of the outstanding California Common Stock.

       4.4 Termination.  This Agreement may be
terminated and the Merger and other transactions
provided for by this Agreement abandoned at any
time prior to the Effective Time, whether before
or after adoption and approval of this Agreement
at the Shareholders' Meeting, by action of the
Board of Directors of Penederm California if the
Board determines that the consummation of the
transactions contemplated by this Agreement
would not, for any reason, be in the best
interests of Penederm California and its
shareholders.

       4.5 Entire Agreement.  This Agreement
(including any exhibits), contains the entire
agreement among the parties with respect to the
Merger and supersedes all prior and concurrent
arrangements, letters of intent or understandings 
relating to the Merger.

       4.6 Counterparts.  This Agreement may be
executed in two or more counterparts, each of
which shall be an original, but all of which
when taken together shall constitute one and the
same agreement. This Agreement shall become
effective when one or more counterparts has been
signed by each of the parties and delivered to
each of the other parties.

       4.7 Headings.  The article, section and
paragraph headings in this Agreement have been
inserted for identification and reference and
shall not by themselves determine the meaning
or interpretation of any provision of this
Agreement.

       4.8 Governing Law.  This Agreement shall
be governed by and construed in accordance with
the laws of the State of Delaware and, so far
as applicable, the merger provisions of the
California General Corporation Law.

  IN WITNESS WHEREOF, the parties have caused
this Agreement to be executed as of the date
first above written.

                      PENEDERM INCORPORATED,
                      a California corporation


                      By:
                      Title:

                      By:
                      Title:


                      PENEDERM INCORPORATED,
                      a Delaware corporation



                      By:
                      Title:

                      By:
                      Title:








                              
                           APPENDIX B




                  CERTIFICATE OF INCORPORATION
                               OF
                     PENEDERM INCORPORATED




     The undersigned, for purposes of incorporating and

organizing a corporation under the General Corporation Law of the

State of Delaware, does hereby certify as follows:



     FIRST.  The name of the corporation is Penederm

Incorporated.



     SECOND.  The name of its registered office in the State of

Delaware is Corporation Service Company.  The address of its

registered agent in the State of Delaware is 1013 Centre Road,

City of Wilmington, County of New Castle, Delaware 19805.



     THIRD.  The nature of the business or purposes to be

conducted or promoted is to engage in any lawful act or activity

for which corporations may be organized under the General

Corporation Law of the State of Delaware.



     FOURTH.  The total number of shares of all classes of

capital stock which the corporation shall have authority to issue

is 40,000,000 shares, comprised of 30,000,000 shares of Common

Stock with a par value of $.01 per share (the "Common Stock") and

10,000,000 shares of Preferred Stock with a par value of $.01 per

share (the "Preferred Stock").  A description of the respective

classes of stock and a statement of the designations,

preferences, voting powers (if any), relative, participating,

optional or other special rights and privileges and the

qualifications, limitations and restrictions of the Preferred

Stock and Common Stock are as follows:



          A.   PREFERRED STOCK



               1.  In General.  The Preferred Stock may be issued

in one or more series at such time or times and for such

consideration as the board of directors may determine.  Each

series shall be designated so as to distinguish the shares of

that series from the shares of all other series and classes.

Except as may be expressly provided in this Certificate of

Incorporation, including any certificate of designations for a

series of Preferred Stock, different series of Preferred Stock

shall not be construed to constitute different classes of shares

for the purpose of voting by classes.



               2.  Certificates of Designation.  The board of

directors is authorized, subject to any limitations prescribed by

law, to provide for the issuance of the shares of Preferred Stock

in one or more series, and by filing a certificate pursuant to

the applicable law of the State of Delaware, to establish from

time to time the number of shares to be included in each such

series, and to fix the designation, powers, preferences and

rights of the shares of each such series and any qualifications,

limitations or restrictions thereof.  The number of authorized

share of Preferred Stock may be increased or decreased (but not

below the number of shares thereof then outstanding) by the

affirmative vote of the holders of a majority of the Common

Stock, without a vote of the holders of the Preferred Stock, or

of any series thereof, unless a vote of any such holders is

required pursuant to the certificate or certificates establishing

the series of Preferred Stock.



           B.  COMMON STOCK



               1.  Relative Rights of Preferred Stock and Common

Stock.  Except as otherwise required by this Certificate of

Incorporation, all powers, preferences and rights and

qualifications, limitations, or restrictions of the Common Stock

are subject to those that may be fixed with respect to any shares

of the Preferred Stock.



               2.  Voting Rights.  Except as otherwise required

by law or this Certificate of Incorporation, including any

certificate of designation for a series of Preferred Stock, each

holder of Common Stock shall have one vote in respect of each

share of stock held of record by that holder on the books of the

corporation for the election of directors and on all matters

submitted to a vote of stockholders of the corporation.



               3.  Dividends.  Subject to any preferential rights

of the Preferred Stock, the holders of shares of Common Stock

shall be entitled to receive, when and if declared by the board

of directors, out of the assets of the corporation which by law

are available therefor, dividends payable in cash, in property or

in shares of capital stock.



               4.  Dissolution, Liquidation or Winding Up.  In

the event of any dissolution, liquidation or winding up of the

affairs of the corporation, after distribution in full of the

preferential amounts, if any, to be distributed to the holders of

shares of the Preferred Stock, holders of Common Stock shall be

entitled, unless otherwise provided by law or this Certificate of

Incorporation, including any certificate of designation for a

series of Preferred Stock, to receive all of the remaining assets

of the corporation of whatever kind available for distribution to

stockholders ratably in proportion to the number of shares of

Common Stock held by them.



     FIFTH.  The corporation is to have perpetual existence.



     SIXTH.  Any action required or permitted to be taken by the

stockholders of the corporation must be effected at an annual or

special meeting of stockholders of the corporation and may not be

effected by any consent in writing of the stockholders.   Special

meetings of stockholders of the corporation may be called only by

the corporation's Board of Directors, its Chair of the Board of

Directors or its President.  Business transacted at special

meetings shall be confined to the purpose or purposes stated in

the notice of meeting.



     SEVENTH.



           A.  In furtherance and not in limitation of the powers

conferred by the laws of the State of Delaware, the board of

directors of the corporation is expressly authorized to adopt,

amend or repeal the by-laws of the corporation.



          B.  Elections of directors need not be by written

ballot unless the by-laws of the corporation so provide.



          C.  The books of the corporation may be kept at such

place within or without the State of Delaware as the by-laws of

the corporation may provide or as may be designated from time to

time by the board of directors of the corporation.



     EIGHTH.  Whenever a compromise or arrangement is proposed

between this corporation and its creditors or any class of them

and/or between this corporation and its stockholders or any class

of them, any court of equitable jurisdiction within the State of

Delaware may, on the application in a summary way of this

corporation or of any creditor or stockholder thereof or on the

application of any receiver or receivers appointed for this

corporation under Section 291 of Title 8 of the Delaware Code or

on the application of trustees in dissolution or of any receiver

or receivers appointed for this corporation under Section 279 of

Title 8 of the Delaware Code, order a meeting of the creditors or

class of creditors, and/or of the stockholders or class of

stockholders of this corporation, as the case may be, to be

summoned in such manner as that court directs.  If a majority in

number representing three-fourths in value of the creditors or

class of creditors, and/or of the stockholders or class of

stockholders of this corporation, as the case may be, agree to

any compromise or arrangement and to any reorganization of this

corporation as a consequence of such compromise or arrangement,

the compromise or arrangement and the reorganization shall, if

sanctioned by the court to which the application has been made,

be binding on all the creditors or class of creditors, and/or on

all the stockholders or class of stockholders, of this

corporation, as the case may be, and also on this corporation.



     NINTH.  No director of the corporation shall be personally

liable to the corporation or its stockholders for monetary

damages for breach of fiduciary duty as a director, except for

liability: (a) for any breach of the director's duty of loyalty

to the corporation or its stockholders; (b) for acts or omissions

not in good faith or which involve intentional misconduct or a

knowing violation of law; (c) under Section 174 of the Delaware

General Corporation Law or (d) for any transaction from which the

director derived any improper personal benefit.  If the Delaware

General Corporation Law is amended to authorize corporate action

further eliminating or limiting the personal liability of

directors, then the liability of a director of the corporation

shall be eliminated or limited to the fullest extent permitted by

the Delaware General Corporation Law, as so amended.  Any repeal

or modification of this paragraph shall not adversely affect any

right or protection of a director of the corporation existing at

the time of the repeal or modification.



     TENTH.



          A.   RIGHT TO INDEMNIFICATION



               Each person who was or is made a party or is

threatened to be made a party to or is involved in any action,

suit or proceeding, whether civil, criminal, administrative or

investigative (a "proceeding"), by reason of the fact that he or

she is or was a director, officer or employee of the

corporation or is or was serving at the request of the

corporation as a director or officer, employee or agent of

another corporation, or of a partnership, joint venture, trust or

other enterprise, including service with respect to employee

benefit plans, whether the basis of such proceeding is alleged

action in an official capacity as a director, officer, employee

or agent or in any other capacity while serving as a director,

officer, employee or agent, shall be indemnified and held harmless 

by the corporation to the fullest extent authorized or permitted by

the Delaware General Corporation Law, as the same exists or may

hereafter be amended (but, in the case of any such amendment,

only to the extent that such amendment permits the corporation to

provide broader indemnification rights than that law permitted

the corporation to provide before the amendment) against all

expenses, liabilities and losses (including, without limitation,

attorneys' fees, judgments, fines, ERISA excise taxes and

penalties and amounts paid or to be paid in settlement)

reasonably incurred or suffered by such person in connection

therewith.  Such indemnification shall continue as to a person

who has ceased to be a director, officer, employee or agent and

shall inure to the benefit of his or her heirs, executors and

administrators.  However, the corporation shall indemnify any

such person seeking indemnity in connection with an action, suit

or proceeding (or part thereof) initiated by that person only if

that action, suit or proceeding (or part thereof) was authorized

by the board of directors of the corporation.  The rights set

forth in this Article TENTH shall be contract rights and shall

include the right to be paid expenses incurred in defending any

such proceeding in advance of its final disposition.  However,

the payment of such expenses incurred by a director or officer of

the corporation in his or her capacity as a director or officer

(and not in any other capacity in which service was or is

rendered by such person while a director or officer, including,

without limitation, service to an employee benefit plan) in

advance of the final disposition of such proceeding shall be made

only upon delivery to the corporation of an undertaking, by or on

behalf of such director or officer, to repay all amounts so

advanced if it should be determined ultimately that such director

or officer is not entitled to be so indemnified.



          B.   RIGHT OF CLAIMANT TO BRING SUIT



               If a claim under Paragraph A of this Article TENTH

is not paid in full by the corporation within 90 days after a

written claim has been received by the corporation, the claimant

may at any time thereafter bring suit against the corporation to

recover the unpaid amount of the claim.  If successful in whole

or in part, the claimant shall be entitled to be paid the expense

of prosecuting that claim.  It shall be a defense to any such

action (other than an action brought to enforce a claim for

expenses incurred in defending any proceeding in advance of its

final disposition where the required undertaking, if any, has

been tendered to this corporation) that the claimant has not met

the standards of conduct which make it permissible under the

Delaware General Corporation Law for the corporation to indemnify

the claimant for the amount claimed.  However, the burden of

proving such defense shall be on the corporation.  Neither the

failure of the corporation (including its board of directors,

independent legal counsel or its stockholders) to have made a

determination before the commencement of such action that

indemnification of the claimant is proper in the circumstances

because he or she has met the applicable standard of conduct set

forth in the Delaware General Corporation Law, nor an actual

determination by the corporation (including its board of

directors, independent legal counsel or its stockholders) that

the claimant has not met such applicable standard of conduct,

shall be a defense to the action or create a presumption that the

claimant has not met the applicable standard of conduct.



          C.   NON-EXCLUSIVITY OF RIGHTS



               The rights conferred on any person by Paragraphs A

and B of this Article TENTH shall not be exclusive of any other

rights which such person may have or hereafter may acquire under

any statute, provision of the Certificate of Incorporation,

by-law, agreement, vote of stockholders or of disinterested

directors, or otherwise.



          D.   EXPENSES AS A WITNESS



               To the extent that any director, officer or

employee of the corporation is by reason of such position, 

or a position with another entity at the request of the

corporation, a witness in any action, suit or proceeding, he or

she shall be indemnified against all costs and expenses actually

and reasonably incurred by him or her on his or her behalf in

connection therewith.



          E.   INDEMNITY AGREEMENTS



               The corporation may enter into agreements with any

director, officer, employee or agent of the corporation or any

person who serves at the request of the corporation as a

director, officer, employee, or agent of another corporation or

other enterprise, providing for indemnification to the fullest

extent permissible under the Delaware General Corporation Law.




          F.   EFFECT OF REPEAL OR MODIFICATION



               Any repeal or modification of this Article TENTH

shall not adversely affect any right of indemnification of a

director, officer or employee or agent of the corporation

existing at the time of such repeal or modification with respect

to any action or omission occurring before the repeal or

modification.



          G.   SEPARABILITY



               Each and every paragraph, sentence, term and

provision of this Article TENTH is separate and distinct.  If any

paragraph, sentence, term or provision is held to be invalid or

unenforceable for any reason, such invalidity or unenforceability

shall not affect the validity or enforceability of any other such

paragraph, sentence, term or provision.  To the extent required

in order to make any such paragraph, sentence, term or provision

of this Article TENTH valid or enforceable, the corporation

shall, and the indemnitee or potential indemnitee may, request a

court of competent jurisdiction to modify the paragraph,

sentence, term or provision in order to preserve its validity and

provide the broadest possible indemnification permitted by

applicable law.



          H.   INSURANCE



               The corporation may maintain insurance, at its

expense, to protect itself and any director, officer, employee or

agent of the corporation or another corporation, partnership,

joint venture, trust or other enterprise against any expense,

liability or loss of the type referred to in this Article TENTH,

whether or not the corporation would have the power to indemnify

such person against such expense, liability or loss under

applicable law.



     ELEVENTH.  The corporation reserves the right to amend or

repeal any provision of this Certificate of Incorporation, in the

manner now or hereafter prescribed by statute, and all rights

conferred upon any stockholders by this Certificate of

Incorporation are granted subject to this reservation.



     TWELFTH.  The powers of the incorporator are to terminate

upon the filing of this Certificate of Incorporation with the

Secretary of the State of Delaware.  The name and mailing address

of the person who is to serve as the initial director of the

corporation until the first annual meeting of stockholders of the

corporation, or until his successor is elected and qualified is:

Michael Bates, Penederm Incorporated, 320 Lakeside Drive, Foster

City, California 94404.



     The undersigned incorporator hereby acknowledges that the

foregoing Certificate of Incorporation is his act and deed on

this _____ day of _________________, 1997.



                                   ______________________________
                                   Michael Bates, Incorporator




                              
                          APPENDIX C


                           BYLAWS OF

                     PENEDERM INCORPORATED


                            OFFICES

          1.  Registered Office.   The registered office of the
corporation shall be in the City of Wilmington, County of New
Castle, State of Delaware.

          2.  Other Offices.  The corporation may also have
offices at such other places both within and without the State of
Delaware as the board of directors may from time to time
determine or the business of the corporation may require.


                          STOCKHOLDERS

          3.   Annual Meeting.  Unless the board of directors or
the President of the corporation selects a different time or
date, the annual meeting of stockholders shall be held at 11:00
a.m. on the first Tuesday of the fifth calendar month following
the end of the corporation's fiscal year.  The annual meeting
shall be for the purpose of electing a board of directors and
transacting such other business as may properly be brought before
the meeting.

          4.   Special Meeting.  Special meetings of stockholders
may be called at any time by the board of directors, the Chairman
of the Board or the President of the corporation.

          5.   Place.  Meetings of stockholders shall be held at
the principal executive office of the corporation or at any other
place, within or without California, which is designated by the
board of directors or the President.

          6.   Notice.

          (a)  Annual and Special Meetings.  A written notice of
each meeting of stockholders shall be given not more than 60 days
and, except as provided below, not less than ten days before the
meeting to each stockholder entitled to vote at the meeting.  The
notice shall state the place, date and hour of the meeting and,
if directors are to be elected at the meeting, the names of the
nominees intended to be presented by management for election.
The notice shall also state (i) in the case of an annual meeting,
those matters which the board of directors intends to present for
action by the stockholders, and (ii) in the case of a special
meeting, the general nature of the business to be transacted and
that no other business may be transacted.  Notice shall be
delivered personally, by mail or other means addressed to the
stockholder at the address of such stockholder appearing on the
books of the corporation, the address given by the stockholder to
the corporation for the purpose of notice or as otherwise
provided by law.

          (b)  Adjourned Meetings.  Notice of an adjourned
meeting need not be given if (i) the meeting is adjourned for 45
days or less, (ii) the time and place of the adjourned meeting
are announced at the meeting at which the adjournment is taken
and (iii) no new record date is fixed for the adjourned meeting.
Otherwise, notice of the adjourned meeting shall be given as in
the case of an original meeting.

          7.   Record Date.  The board of directors may fix in
advance a record date for the determination of the stockholders
entitled to notice of any meeting, to vote, to receive any
dividend or other distribution or allotment of rights or to
exercise any rights.  The record date shall be not more than 60
nor less than ten days prior to the date of the meeting nor more
than 60 days prior to such other action.  If no record date is
fixed, the record date for determining stockholders entitled to
notice of or to vote at a meeting of stockholders shall be at the
close of business on the business day next preceding the day on
which notice is given, or, if notice is waived, the close of
business on the business day next preceding the day on which the
meeting is held.  Except as otherwise provided by law, when a
record date is fixed, as provided herein, only stockholders on
the record date are entitled to notice and to vote, to receive
the dividend, distribution or allotment of rights or to exercise
rights, as the case may be, notwithstanding any transfer of
shares on the books of the corporation occurring after the record
date.  Except as otherwise provided by law, the corporation shall
be entitled to treat the holder of record of any shares as the
holder in fact of such shares and shall not be bound to recognize
any equitable or other claim to or interest in such shares on the
part of any other person, whether or not the corporation shall
have express or other notice of such claim or interest.  A
determination of stockholders of record entitled to notice of or
to vote at a meeting of stockholders shall apply to any
adjournment of the meeting unless the board of directors fixes a
new record date.  The board of directors shall fix a new record
date if the adjourned meeting takes place more than 45 days after
the date set for the original meeting.

          8.   Quorum.  The holders of a majority of the stock
issued and outstanding and entitled to vote thereat, present in
person or represented by proxy, shall constitute a quorum at all
meetings of the stockholders for the transaction of business
except as otherwise provided by statute or by the certificate of
incorporation.  If, however, such quorum shall not be present or
represented at any meeting of the stockholders, the stockholders
entitled to vote thereat, present in person or represented by
proxy, shall have power to adjourn the meeting from time to time,
without notice other than announcement at the meeting, until a
quorum shall be present or represented.  At such adjourned
meeting at which a quorum shall be present or represented, any
business may be transacted which might have been transacted at
the meeting as originally noticed.  If the adjournment is for
more than 30 days, or if after the adjournment a new record date
is fixed for the adjourned meeting, a notice of the adjourned
meeting shall be given to each stockholder of record entitled to
vote at the meeting.

          9.   Required Vote.  When a quorum is present at any
meeting, the vote of the holders of a majority of the stock
having voting power present in person or represented by proxy
shall decide any question brought before such meeting, unless the
question is one upon which by express provision of statute or of
the certificate of incorporation, a different vote is required,
in which case such express provision shall govern and control the
decision of such question.

          10.  Proxies and Voting.  At any meeting of the
stockholders, every stockholder entitled to vote may vote in
person or by proxy authorized by an instrument in writing filed
in accordance with the procedure established for the meeting.
Unless otherwise provided in the certificate of incorporation,
each stockholder shall at every meeting of the stockholders be
entitled to one vote in person or by proxy for each share of the
capital stock having voting power held by such stockholder, but
no proxy shall be voted on after three years from its date,
unless the proxy provides for a longer period.

          11.  Lost Stock Certificates.  The corporation may
cause a new stock certificate to be issued in place of any
certificate previously issued by the corporation alleged to have
been lost, stolen or destroyed.  The corporation may, at its
discretion and as a condition precedent to such issuance, require
the owner of such certificate to deliver an affidavit stating
that such certificate was lost, stolen or destroyed or to give
the corporation a bond or other security sufficient to indemnify
it against any claim that may be made against it, including any
expense or liability, on account of the alleged loss, theft or
destruction or the issuance of a new certificate.


                      BOARD OF DIRECTORS

          12.  Number.  The number of directors who shall
constitute the whole board not be less than five nor more than
nine.  The exact number of directors shall be determined from
time to time by resolution of the board of directors.

          13.  Powers.  The business of the corporation shall be
managed by or under the direction of its board of directors,
which may exercise all such powers of the corporation and do all
such lawful acts and things as are not by statute or by the
certificate of incorporation or by these bylaws directed or
required to be exercised or done by the stockholders.

          14.  Election.  Except as provided in Section 15, the
directors shall be elected at the annual meeting of the
stockholders.  Each director elected shall hold office until his
or her successor is elected and qualified.  Directors need not be
stockholders.

          15.   Term of Office and Vacancies.  Vacancies and
newly created directorships resulting from any increase in the
authorized number of directors elected by all of the stockholders
having the right to vote as a single class may be filled by a
majority of the directors then in office, though less than a
quorum, or by a sole remaining director; whenever the holders of
any class or classes of stock or series thereof are entitled,
pursuant to the certificate of incorporation, to elect one or
more directors, vacancies and newly created directorships of such
class or classes or series may be filled by a majority of the
directors elected by such class or classes or series then in
office, or by a sole remaining director so elected.  The
directors so chosen shall hold office until the next annual
election and until their successors are duly elected and shall
qualify, unless sooner displaced.  If there are no directors in
office, then an election of directors may be held in the manner
provided by statute.

          16.  Removal.  Unless otherwise restricted by the
certificate of incorporation, bylaws or statute, any director or
the entire board of directors may be removed, with or without
cause, by the holders of a majority of shares entitled to vote at
an election of directors.

          17.  Resignation.  Any director may resign by giving
notice to the board of directors, the Chairman of the Board, the
President or the Secretary.  The resignation of a director shall
be effective when given unless the director specifies a later
time.  The resignation shall be effective regardless of whether
it is accepted by the corporation.

          18.  Compensation.  Unless otherwise restricted by the
certificate of incorporation or these bylaws, the board of
directors shall have the authority to fix the compensation of
directors.  The directors may be paid their expenses, if any, of
attendance at each meeting of the board of directors and may be
paid a fixed sum for attendance at each meeting of the board of
directors or a stated salary as director.  No such payment shall
preclude any director from serving the corporation in any other
capacity and receiving compensation therefor.  Members of special
or standing committees may be allowed like compensation for
attending committee meetings.

          19.  Committees.  The board of directors may, by
resolution passed by a majority of the whole board, designate one
or more committees, each committee to consist of one or more of
the directors of the corporation.  The board many designate one
or more directors as alternate members of any committee, who may
replace any absent or disqualified member at any meeting of the
committee.

          Any committee, to the extent provided in the resolution
of the board of directors, shall have and may exercise all the
powers and authority of the board of directors in the management
of the business and affairs of the corporation, and may authorize
the seal of the corporation to be affixed to all papers which may
require it; but no committee shall have the power or authority of
the board of directors in reference to:

          (a)  amending the certificate of incorporation (except
to the extent provided in resolutions of the board of directors
and permitted by the General Corporation Law of the State of
Delaware);

          (b)  adopting an agreement of merger or consolidation;

          (c)  recommending to the stockholders the sale, lease
or exchange of all or substantially all of the corporation's
property and assets;

          (d)  recommending to the stockholders a dissolution of
the corporation or a revocation of a dissolution;

          (e)  adopting, amending or repealing the bylaws of the
corporation;

          (f)  filling a vacancy on the board of directors;

          (g)  amending or repealing any resolution of the board
of directors which by its express terms is not so amendable or
repealable;


          (h)  declaring or making a distribution to the
stockholders of the corporation, except at a rate, in a periodic
amount or within a price range determined by the board of
directors; or

          (i)  appointing any other committees of the board or
the members of any committee.

Unless the resolution or the certificate of incorporation
expressly so provide, no such committee shall have the power or
authority to declare a dividend, to authorize the issuance of
stock or to adopt a certificate of ownership and merger pursuant
to the General Corporation Law of Delaware.  Such committee or
committees shall have such name or names as may be determined
from time to time by resolution adopted by the board of
directors.

          Each committee shall keep regular minutes of its
meetings and report the same to the board of directors when
required.

          20.  Time and Place of Meetings and Telephone Meetings.
Unless the board of directors determines otherwise, the board
shall hold a regular meeting during each quarter of the
corporation's fiscal year.  One such meeting shall take place
immediately following the annual meeting of stockholders.  All
meetings of directors shall be held at the principal executive
office of the corporation or at such other place, within or
without the State of Delaware, as shall be designated in the
notice of the meeting or in a resolution of the board of
directors.  Directors may participate in a meeting through use of
conference telephone or similar communications equipment,
provided that all members participating in the meeting can hear
each other.

          21.  Call.  Meetings of the board of directors, whether
regular or special, may be called by the Chairman of the Board,
the President, the Secretary, the Treasurer or any two directors.

          22.  Notice.  Regular meetings of the board of
directors may be held without notice if the time of such meetings
has been fixed by the board.  Special meetings shall be held upon
four days' notice by mail or 48 hours' notice delivered
personally or by telephone or telegraph, and regular meetings
shall be held upon similar notice if notice is required for such
meetings.  Neither a notice nor a waiver of notice must specify
the purpose of any regular or special meeting.  Notice of the
time and place of holding an adjourned meeting need not be given
to absent directors if the time and place of the adjourned
meeting is announced at the meeting at which the adjournment is
taken, but if a meeting is adjourned for more than 24 hours,
notice of the adjourned meeting shall be given prior to the time
of such meeting to the directors who were not present at the time
of the adjournment.

          23.  Meeting Without Regular Call and Notice.  The
transactions of any meeting of the board of directors, however
called and noticed or wherever held, are as valid as though had
at a meeting duly held after regular call and notice if a quorum
is present and if, either before or after the meeting, each of
the directors not present signs a written waiver of notice, a
consent to the holding of the meeting or an approval of the
minutes of the meeting.  For such purposes, a director shall not
be considered present at a meeting if, although in attendance at
the meeting, the director protests the lack of notice prior to
the meeting or at its commencement.

          24.  Action Without Meeting.  Any action required or
permitted to be taken by the board of directors may be taken
without a meeting, if all of the members of the board
individually or collectively consent in writing to such action.

          25.  Quorum and Required Vote.  At all meetings of the
board a majority of the directors shall constitute a quorum for
the transaction of business and the act of a majority of the
directors present at any meeting at which there is a quorum shall
be the act of the board of directors, except as may be otherwise
specifically provided by statute or by the certificate of
incorporation.  If a quorum shall not be present at any meeting
of the board of directors the directors present thereat may
adjourn the meeting from time to time, without notice other than
announcement at the meeting, until a quorum shall be present.

          26.  Committee Meetings.  The principles set forth in
Sections 20 through 25 of these bylaws shall apply to committees
of the board of directors and to actions taken by such
committees.

                             OFFICERS

          27.  Titles and Relation to board of directors.  The
officers of the corporation shall include a Chairman of the Board
or a President or both, a Secretary and a Treasurer.  The board
of directors may also choose one or more Vice Presidents,
Assistant Secretaries, Assistant Treasurers or other officers.
Any number of offices may be held by the same person.  All
officers shall perform their duties and exercise their powers
subject to the direction of the board of directors.

          28.  Election, Term of Office and Vacancies.  At its
regular meeting after each annual meeting of stockholders, the
board of directors shall choose the officers of the corporation.
The board may choose additional officers or fill vacant offices
at any other time.  No officer must be a member of the board of
directors except the Chairman of the Board.  The officers shall
hold office until their successors are chosen, except that the
board of directors may remove any officer at any time.

          29.  Resignation.  Any officer may resign at any time
upon notice to the corporation without prejudice to the rights,
if any, of the corporation under any contract to which the
officer is a party.  The resignation of an officer shall be
effective when given unless the officer specifies a later time.
The resignation shall be effective regardless of whether it is
accepted by the corporation.

          30.  Chairman of the Board; President.  If the board of
directors elects a Chairman of the Board, such officer shall
preside over all meetings of the board of directors and of
stockholders.  If there be no Chairman of the Board, the
President shall perform such duties.  The board of directors
shall designate either the Chairman of the Board or the President
as the chief executive officer and may prescribe the duties and
powers of the chief executive officer.  If there is no Chairman
of the Board, the President shall be the chief executive officer.

          31.  Secretary.  Unless otherwise determined by the
board of directors or the chief executive officer, the Secretary
shall have the following powers and duties:

          (a)  Record of Corporate Proceedings.  The Secretary
shall attend all meetings of stockholders and the board of
directors and its committees and shall record all votes and the
minutes of such meetings in a book to be kept at the principal
executive office of the corporation or at such other place as the
board may determine.  The Secretary shall keep at the
corporation's principal executive office, if in California, or at
its principal business office in California if the principal
executive office is not in California, the original or a copy of
these bylaws, as amended.

          (b)  Record of Shares.  Unless a transfer agent is
appointed by the board of directors to keep a share register, the
Secretary shall keep a share register at the principal executive
office of the corporation showing the names of the stockholders
and their addresses, the number and class of shares held by each,
the number and date of certificates issued and the number and
date of cancellation of each certificate surrendered for
cancellation.

          (c)  Notices.  The Secretary shall give such notices as
may be required by law or these bylaws.

          32.  Treasurer.  Unless the board of directors
designates another chief financial officer, the Treasurer shall
be the chief financial officer of the corporation.  Unless
otherwise determined by the board of directors or the chief
executive officer, the Treasurer shall have custody of the
corporate funds and securities, shall keep adequate and correct
accounts of the corporation's properties and business
transactions, shall disburse such funds of the corporation as may
be ordered by the board or the chief executive officer (taking
proper vouchers for such disbursements), and shall render to the
chief executive officer and the board, at regular meetings of the
board or whenever the board may require, an account of all
transactions and the financial condition of the corporation.

          33.  Other Officers.  The other officers of the
corporation, if any, shall exercise such powers and perform such
duties as the board of directors or the chief executive officer
shall prescribe.

          34.  Salaries.  The board of directors shall fix the
salary of the chief executive officer and may fix the salaries of
other employees of the corporation, including the other officers.
If the board does not fix the salaries of the other officers, the
chief executive officer shall fix such salaries.


                         AMENDMENT OF
                            BYLAWS

          35.  Bylaws may be adopted, amended or repealed by the
affirmative vote of a majority of the outstanding shares entitled
to vote or by the board of directors.






                     PENEDERM INCORPORATED
                     EQUITY INCENTIVE PLAN



SECTION 1.  PURPOSE; DEFINITIONS.

    (a) Purpose.  The purpose of the Plan is to provide selected
eligible employees and directors of, and consultants to, Penederm
Incorporated, a California corporation, its subsidiaries and
affiliates an opportunity to participate in the Company's future
by offering them an opportunity to acquire stock in the Company
so as to retain, attract and motivate them.

    (b) Definitions.  For purposes of the Plan, the following
terms have the following meanings:

       (i)  "Award" means any award under the Plan, including any
Option, Restricted Stock, Stock Purchase Right or Performance
Share Award.

      (ii)  "Award Agreement" means, with respect to each Award,
the signed written agreement between the Company and the Plan
participant setting forth the terms and conditions of the Award.

     (iii)  "Board" means the Board of Directors of the Company.

      (iv)  "Change in Control" has the meaning set forth in
Section 9(a).

       (v)  "Change in Control Price" has the meaning set forth
in Section 9(c).

      (vi)  "Code" means the Internal Revenue Code of 1986, as
amended from time to time, and any successor statute.

     (vii)  "Commission" means the Securities and Exchange
Commission and any successor agency.

    (viii)  "Committee" means the Committee referred to in
Section 2, or the Board in its capacity as administrator of the
Plan in accordance with Section 2.

      (ix)  "Company" means Penederm Incorporated, a California
corporation.

       (x)  "Disability" means permanent and total disability as
determined by the Committee for purposes of the Plan.

      (xi)  "Exchange Act" means the Securities Exchange Act of
1934, as amended from time to time, and any successor statute.

     (xii)  "Fair Market Value" means as of any given date (a) if
the Stock is listed on any established stock exchange or a
national market system, the closing sales price for the Stock or
the closing bid if no sales were reported, as quoted on such
system or exchange, as reported in the Wall Street Journal; or
(b) in the absence of an established market for the Stock, the
fair market value of the Stock as determined by the Committee in
good faith.

    (xiii)  "Incentive Stock Option" means any Option intended to
be and designated as an "incentive stock option" within the
meaning of Section 422 of the Code.

     (xiv)  "Nonqualified Stock Option" means any Option that is
not an Incentive Stock Option.

      (xv)  "Option" means an option granted under Section 5.

     (xvi)  "Performance Period" means the period determined by
the Committee under Section 8(a).

    (xvii)  "Performance Share" means the equivalent, as of any
time such assessment is made, of the Fair Market Value of one
share of Stock.

    (xviii) "Performance Share Award" means an Award under
Section 8.

     (xix)  "Plan" means this Penederm Incorporated Equity
Incentive Plan, as amended from time to time.

      (xx)  "Restricted Stock" means an Award of Stock subject to
restrictions, as more fully described in Section 6.

     (xxi)  "Restriction Period" means the period determined by
the Committee under Section 6(b).

    (xxii)  "Rule 16b-3" means Rule 16b-3 under Section 16(b) of
the Exchange Act, as amended from time to time, and any successor
rule.

    (xxiii) "Stock" means the no par value Common Stock of the
Company, and any successor security.

    (xxiv)  "Stock Purchase Right" means an Award granted under
Section 7.

     (xxv)  "Subsidiary" has the meaning set forth in Section 424
of the Code.

    (xxvi)  "Tax Date" means the date defined in Section 10(f).

    (xxvii) "Termination" means, for purposes of the Plan, with
respect to a participant, that the participant has ceased to be,
for any reason, employed by,
consulting to, or a director of, the Company, a subsidiary or an
affiliate; provided, that for purposes of this definition, if so
determined by the President of the Company, in his sole
discretion, Termination shall not include a change in status from
an employee of, to a consultant to or director of, the Company or
any subsidiary or affiliate, or vice versa.

SECTION 2.  ADMINISTRATION.

    (a) Committee.  The Plan shall be administered by the Board
or, upon delegation by the Board, by a committee of the Board
appointed by the Board that will satisfy Rule 16b-3 and Section
162(m) of the Code, as in effect with respect to the Company from
time to time.  In connection with the administration of the Plan,
the Committee shall have the powers possessed by the Board.  The
Committee may act only by a majority of its members, except that
the Committee may from time to time select another committee or
one or more other persons to be responsible for any matters so
long as such selection comports with the requirements of Section
162(m) of the Code and Rule 16b-3.  The Board at any time may
abolish the Committee and revest in the Board the administration
of the Plan.

    (b) Authority.  The Committee shall grant Awards to eligible
employees and consultants.  In particular and without limitation,
the Committee, subject to the terms of the Plan, shall:

        (i) select the directors, officers, other key employees
and consultants to whom Awards may be granted;

        (ii)    determine whether and to what extent Awards are
to be granted under the Plan;

        (iii)   determine the number of shares to be covered by
each Award granted under the Plan;

        (iv)    determine the terms and conditions of any Award
granted under the Plan and any related loans to be made by the
Company, based upon factors determined by the Committee; and

        (v) determine to what extent and under what circumstances
any Award payments may be deferred by a participant.

    (c) Committee Determinations Binding.  The Committee may
adopt, alter and repeal administrative rules, guidelines and
practices governing the Plan as it from time to time shall deem
advisable, may interpret the terms and provisions of the Plan,
any Award and any Award Agreement and may otherwise supervise the
administration of the Plan.  Any determination made by the
Committee pursuant to the provisions of the Plan with respect to
any Award shall be made in its sole discretion at the time of the
grant of the Award or, unless in contravention of any express
term of the Plan or Award, at any later time.  All decisions made
by the  Committee under the Plan shall be binding on all persons,
including the Company and Plan participants.

SECTION 3.  STOCK SUBJECT TO PLAN.

    (a) Number of Shares.  The total number of shares of Stock
reserved and available for issuance pursuant to Awards under this
Plan and pursuant to options under each of this Company's
Employee Stock Option Plan and Consultant Stock Option Plan shall
be 1,712,500 shares.  Such shares may consist, in whole or in
part, of authorized and unissued shares or treasury shares or
shares reacquired in private transactions or open market
purchases, but all shares issued under the Plan, the Employee
Stock Option Plan and the Consultant Stock Option Plan,
regardless of source shall be counted against the 1,712,500 share
limitation.  If any Option terminates or expires without being
exercised in full or if any shares of Stock subject to an Award
are forfeited, or if an Award otherwise terminates without a
payment being made to the participant in the form of Stock, the
shares issuable under such Option or Award shall again be
available for issuance in connection with Awards.  To the extent
an Award is paid in cash, the number of shares of Stock
representing, at Fair Market Value on the date of the payment,
the value of the cash payment shall not be available for later
grant under the Plan, the Employee Stock Option Plan or the
Consultant Stock Option Plan.  Any Award under this Plan shall be
governed by the terms of the Plan and any applicable Award
Agreement.

    (b) Adjustments.  In the event of any merger, reorganization,
consolidation, recapitalization, stock dividend, stock split or
other change in corporate structure affecting the Stock, such
substitution or adjustments shall be made in the aggregate number
of shares of Stock reserved for issuance under the Plan, in the
number and exercise price of shares subject to outstanding
Options, and in the number of shares subject to other outstanding
Awards, as may be determined to be appropriate by the Committee,
in its sole discretion; provided, however, that the number of
shares subject to any Award shall always be a whole number.

SECTION 4.  ELIGIBILITY.

    Awards may be granted to directors, officers and other key
employees of, and consultants to, the Company, its subsidiaries
and affiliates.

SECTION 5.  STOCK OPTIONS.

    (a) Types.  Any Option granted under the Plan shall be in
such form as the Committee may from time to time approve.  The
Committee shall have the authority to grant to any participant
Incentive Stock Options, Nonqualified Stock Options or both types
of Options.  Incentive Stock Options may be granted only to
employees of the Company, its parent (within the meaning of
Section 424(e) of the Code) or Subsidiaries.  Any portion of an
Option that is not designated as, or does not qualify as, an
Incentive Stock Option shall constitute a Nonqualified Stock
Option.

    (b) Terms and Conditions.  Options granted under the Plan
shall be subject to the following terms and conditions:

        (i) Option Term.  The term of each Option shall be fixed
by the Committee, but no Incentive Stock Option shall be
exercisable more than ten (10) years after the date the Option is
granted, and no Nonqualified Stock Option shall be exercisable
more than fifteen (15) years after the date the Option is
granted.  If, at the time the Company grants an Incentive Stock
Option, the optionee owns directly or by attribution stock
possessing more than 10% of the total combined voting power of
all classes of stock of the Company, or any parent or Subsidiary
of the Company, the Incentive Stock Option shall not be
exercisable more than five (5) years after the date of grant.

        (ii)    Grant Date.  The Company may grant Options under
the Plan at any time and from time to time before the Plan
terminates.  The Committee shall specify the date of grant or, if
it fails to, the date of grant shall be the date of action taken
by the Committee to grant the Option.  However, if an Option is
approved in anticipation of employment, the date of grant shall
be the date the intended optionee is first treated as an employee
for payroll purposes.

        (iii)   Exercise Price.  The exercise price per share of
Stock purchasable under an Option shall be equal to at least 85%
of the Fair Market Value on the date of grant, and in the case of
Incentive Stock Options shall be equal to at least the Fair
Market Value on the date of grant; provided, however, that if, at
the time the Company grants an Incentive Stock Option, the
optionee owns directly or by attribution stock possessing more
than 10% of the total combined voting power of all classes of
stock of the Company, or any parent or Subsidiary of the Company,
then the exercise price shall be not less than 110% of the Fair
Market Value on the date the Incentive Stock Option is granted.

        (iv)    Exercisability.  Subject to the other provisions
of the Plan, an Option shall be exercisable in its entirety at
grant or at such times and in such amounts as are specified in
the Award Agreement evidencing the Option.  The Committee, in its
absolute discretion, at any time may waive any limitations
respecting the time at which an Option first becomes exercisable
in whole or in part.

        (v) Method of Exercise; Payment.  To the extent the right
to purchase shares has accrued, Options may be exercised, in
whole or in part, from time to time, by written notice from the
optionee to the Company stating the number of shares being
purchased, accompanied by payment of the exercise price for the
shares.

        (vi)    No Disqualification.  Notwithstanding any other
provision in the Plan, no term of the Plan relating to Incentive
Stock Options shall be interpreted, amended or altered nor shall
any discretion or authority granted under the Plan be exercised
so as to disqualify the Plan under Section 422 of the Code or,
without the consent of the optionee affected, to disqualify any
Incentive Stock Option under such Section 422.

SECTION 6.  RESTRICTED STOCK.

    (a) Price.  The Committee may grant to a participant
Restricted Stock.  The grantee shall pay no consideration
therefor.

    (b) Restrictions.  Subject to the provisions of the Plan and
the Award Agreement, during the Restriction Period set by the
Committee, commencing with, and not exceeding ten (10) years
from, the date of such Award, the participant shall not be
permitted to sell, assign, transfer, pledge or otherwise encumber
shares of Restricted Stock.  Within these limits, the Committee
may provide for the lapse of such restrictions in installments
and may accelerate or waive such restrictions, in whole or in
part, based on service, performance or such other factors or
criteria as the Committee may determine.

    (c) Dividends.  Unless otherwise determined by the Committee,
with respect to dividends on shares of Restricted Stock,
dividends payable in cash shall be automatically reinvested in
additional Restricted Stock, and dividends payable in Stock shall
be paid in the form of Restricted Stock.

    (d) Termination.  Except to the extent otherwise provided in
the Award Agreement and pursuant to Section 6(b), in the event of
a Termination during the Restriction Period, all shares still
subject to restriction shall be forfeited by the participant.

SECTION 7.  STOCK PURCHASE RIGHTS.

    (a) Price.  The Committee may grant Stock Purchase Rights
which shall enable the recipients to purchase Stock at a price
equal to not less than 85% of its Fair Market Value on the date
of grant.

    (b) Exercisability.  Stock Purchase Rights shall be
exercisable for a period determined by the Committee not
exceeding 30 days from the date of the grant.

SECTION 8.  PERFORMANCE SHARES.

    (a) Awards.  The Committee shall determine the nature, length
and starting date of the Performance Period for each Performance
Share Award, which period shall be at least one (1) year (subject
to Section 9) and not more than six (6) years.  The consideration
payable by a participant with respect to a Performance Share
Award shall be an amount determined by the Committee in the
exercise of the Committee's discretion at the time of the Award;
provided, that the amount of consideration may be zero and may in
no event exceed 50% of the Fair Market Value at the time of
grant.  The Committee shall determine the performance objectives
to be used in awarding Performance Shares and the extent to which
such Performance Shares have been earned.  Performance Periods
may overlap and participants may participate simultaneously with
respect to Performance Share Awards that are subject to different
Performance Periods and different performance factors and
criteria.  At the beginning of each Performance Period, the
Committee shall determine for each Performance Share Award
subject to such Performance Period the number of shares of Stock
(which may consist of Restricted Stock) to be awarded to the
participant at the end of the Performance Period if and to the
extent that the relevant measures of performance for such
Performance Share Award are met.  Such number of shares of Stock
may be fixed or may vary in accordance with such performance or
other criteria as may be determined by the Committee.  The
Committee may provide that (i) amounts equivalent to interest at
such rates as the Committee may determine, or (ii) amounts
equivalent to dividends paid by the Company upon outstanding
Stock shall be payable with respect to Performance Share Awards.

    (b) Termination.  Except as otherwise provided in the Award
Agreement or determined by the Committee, in the event of a
Termination during a Performance Period, the participant shall
not be entitled to any payment with respect to the Performance
Shares subject to the Performance Period.

    (c) Form of Payment.  Payment shall be made in the form of
cash or whole shares of Stock, as the Committee, in its
discretion, shall determine.

SECTION 9.  CHANGE IN CONTROL.

    (a) Definition of "Change in Control".  For purposes of
Section 9(b), a "Change in Control" means the occurrence of any
one of the following:

        (i) Any "person", as such term is used in Sections 13(d)
and 14(d) of the Exchange Act (other than the Company, a
subsidiary, an affiliate, or a Company employee benefit plan,
including any trustee of such plan acting as trustee) is or
becomes the "beneficial owner" (as defined in Rule 13d-3 under
the Exchange Act), directly or indirectly, of securities of the
Company representing 20% or more of the combined voting power of
the Company's then outstanding securities;

        (ii)    the solicitation of proxies (within the meaning
of Rule 14a-1(k) under the Exchange Act and any successor rule)
with respect to the election of any director of the Company
where such solicitation is for any candidate who is not a
candidate proposed by a majority of the Board in office prior to
the time of such election; or

        (iii)   the dissolution or liquidation (partial or total)
of the Company or a sale of assets involving 30% or more of the
assets of the Company, any merger or reorganization of the
Company whether or not another entity is the survivor, a
transaction pursuant to which the holders, as a group, of all of
the shares of the Company outstanding prior to the transaction
hold, as a group, less than 70% of the shares of the Company
outstanding after the transaction, or any other event which the
Board determines, in its discretion, would materially alter the
structure of the Company or its ownership.

    (b) Impact of Event.  In the event of a "Change in Control"
as defined in Section 9(a), but only if and to the extent so
specifically determined by the Board in its discretion, which
determination may be amended or reversed only by the affirmative
vote of a majority of the persons who were directors at the time
such determination was made, acceleration and valuation
provisions no more favorable to participants than the following
may apply:

        (i) Subject to Section 5(b)(vi), any Options outstanding
as of the date such Change in Control is determined to have
occurred and not then exercisable and vested shall become fully
exercisable and vested.

        (ii)    The restrictions and limitations applicable to
any Restricted Stock and Stock Purchase Rights shall lapse, and
such Restricted Stock shall become fully vested.

        (iii)   The value (net of any exercise price) of all
outstanding Options, Restricted Stock and Stock Purchase Rights,
unless otherwise determined by the Committee at or after grant
and subject to Rule 16b-3, shall be cashed out on the basis of
the "Change in Control Price", as defined in Section 9(c), as of
the date such Change in Control is determined to have occurred or
such other date as the Board may determine prior to the Change in
Control.

        (iv)    Any outstanding Performance Share Awards shall be
vested and paid in full as if all performance criteria had been
met.

    (c) Change in Control Price.  For purposes of this Section 9,
"Change in Control Price" means the highest price per share paid
in any transaction reported on the National Market System of the
National Association of Securities Dealers, Inc. Automated
Quotation System or paid or offered in any bona fide transaction
related to a potential or actual Change in Control of the Company
at any time during the preceding 60-day period as determined by
the Board,  except that, in the case of Incentive Stock Options,
such price shall be based only on transactions reported for the
date on which the Board decides to cash out such Options.

SECTION 10.  GENERAL PROVISIONS.

    (a) Award Grants.  Any Award may be granted either alone or
in addition to other Awards granted under the Plan.  Subject to
the terms and restrictions set forth elsewhere in the Plan, the
Committee shall determine the consideration, if any, payable by
the participant for any Award and, in addition to those set forth
in the Plan, any other terms and conditions of the Awards.  The
Committee may condition the grant or payment of any Award upon
the attainment of specified performance goals or such other
factors or criteria, including vesting based on continued
employment or consulting, as the Committee shall determine.
Performance objectives may vary from participant to participant
and among groups of participants and shall be based upon such
Company, subsidiary, group or division factors or criteria as the
Committee may deem appropriate, including, but not limited to,
earnings per share or return on equity.  The other provisions of
Awards also need not be the same with respect to each recipient.
Unless specified otherwise in the Plan or by the Committee, the
date of grant of an Award shall be the date of action by the
Committee to grant the Award.  The Committee may also substitute
new Options for previously granted Options, including previously
granted Options having higher exercise prices.

    (b) Award Agreement.  As soon as practicable after the date
of an Award grant, the Company and the participant shall enter
into a written Award Agreement identifying the date of grant, and
specifying the terms and conditions of the Award.  Options are
not exercisable until after execution of the Award agreement by
the Company and the Plan participant, but a delay in execution of
the agreement shall not affect the validity of the Option grant.

    (c) Certificates.  All certificates for shares of Stock or
other securities delivered under the Plan shall be subject to
such stock transfer orders, legends and other restrictions as the
Committee may deem advisable under the rules, regulations and
other requirements of the Commission, any market in which the
Stock is then traded and any applicable federal, state or foreign
securities law.

    (d) Termination.  Unless otherwise provided in the applicable
Award Agreement or by the Committee, in the event of Termination
for any reason other than death, retirement or Disability, Awards
held at the date of Termination (and only to the extent then
exercisable or payable, as the case may be) may be exercised in
whole or in part at any time within three (3) months after the
date of Termination, or such lesser period specified in the Award
Agreement (but in no event after the expiration date of the
Award), but not thereafter.  If Termination is due to retirement
or to death or Disability, Awards held at the date of Termination
(and only to the extent then exercisable or payable, as the case
may be) may be exercised in whole or in part by the participant
in the case of retirement or Disability, by the participant's
guardian or legal representative or by the person to whom the
Award is transferred by will or the laws of descent and
distribution, at any time within two (2) years from the date of
Termination or any lesser period specified in the Award Agreement
(but in no event after the expiration of the Award).

    (e) Delivery of Purchase Price.  If and only to the extent
authorized by the Committee, participants may make all or any
portion of any payment due to the Company

        (i)  with respect to the consideration payable for an
Award,

        (ii)  upon exercise of an Award, or

        (iii)  with respect to federal, state, local or foreign
tax payable in connection with an Award, by delivery of (x) cash,
(y) check, or (z) any property other than cash (including a
promissory note of the participant or shares of Stock or
securities) so long as, if applicable, such property constitutes
valid consideration for the Stock under, and otherwise complies
with, applicable law.  No promissory note under the Plan shall
have a term (including extensions) of more than five years or
shall be of a principal amount exceeding 90% of the purchase
price paid by the borrower.

    (f) Tax Withholding.  Any shares or other securities so
withheld or tendered will be valued by the Committee as of the
date they are withheld or tendered; provided, however, that Stock
shall be valued at Fair Market Value on such date.  The value of
the shares withheld or tendered may not exceed the required
federal, state, local and foreign withholding tax obligations as
computed by the Company.  Unless the Committee permits otherwise,
the participant shall pay to the Company in cash, promptly when
the amount of such obligations becomes determinable (the "Tax
Date"), all applicable federal, state, local and foreign
withholding taxes that the Committee in its discretion determines
to result, (i) from the lapse of restrictions imposed upon an
Award, (ii) upon exercise of an Award, or (iii) from a transfer
or other disposition of shares acquired upon exercise or payment
of an Award, or otherwise related to the Award or the shares
acquired in connection with an Award.

        A participant who has received an Award or payment under
an Award may, to the extent, if any, authorized by the Committee
in its discretion, make an election to (x) deliver to the Company
a promissory note of the participant on the terms set forth in
Section 10(e), or (y) tender any such securities to the Company
to pay the amount of tax that the Committee in its discretion
determines to be required to be withheld by the Company;
provided, however, that such election shall be subject to the
disapproval of the Committee.

    (g) No Transferability.  No Award shall be assignable or
otherwise transferable by the participant other than by will or
by the laws of descent and distribution.  During the life of a
participant, an Award shall be exercisable, and any elections
with respect to an Award may be made, only by the participant or
participant's guardian or legal representative.

    (h) Adjustment of Awards; Waivers.  Subject to Section
5(b)(vi), the Committee may adjust the performance goals and
measurements applicable to Awards (i) to take into account
changes in law and accounting and tax rules, (ii) to make such
adjustments as the Committee deems necessary or appropriate to
reflect the inclusion or exclusion of the impact of extraordinary
or unusual items, events or circumstances in order to avoid
windfalls or hardships, and (iii) to make such adjustments as the
Committee deems necessary or appropriate to reflect any material
changes in business conditions.  In the event of hardship or
other special circumstances of a participant and otherwise in its
discretion, the Committee may waive in whole or in part any or
all restrictions, conditions, vesting, or forfeiture with respect
to any Award granted to such participant.

    (i) Non-Competition.  The Committee may condition its
discretionary waiver of a forfeiture, the acceleration of vesting
at the time of Termination of a participant holding any
unexercised or unearned Award, the waiver of restrictions on any
Award, or the extension of the expiration period to a period not
longer than that provided by the Plan upon such participant's
agreement (and compliance with such agreement) to (i) not engage
in any business or activity competitive with any business or
activity conducted by the Company and (ii) be available for
consultations at the request of the Company's management, all on
such terms and conditions (including conditions in addition to
(i) and (ii)) as the Committee may determine.

    (j) Dividends.  The reinvestment of dividends in additional
Stock or Restricted Stock at the time of any dividend payment
pursuant to Section 6(c) shall only be permissible if sufficient
shares of Stock are available under Section 3 for such
reinvestment (taking into account then outstanding Awards).

    (k) Regulatory Compliance.  Each Award under the Plan shall
be subject to the condition that, if at any time the Committee
shall determine that (i) the listing, registration or
qualification of the shares of Stock upon any securities exchange
or for trading in any securities market or under any state or
federal law, (ii) the consent or approval of any government or
regulatory body or (iii) an agreement by the participant with
respect thereto, is necessary or desirable, then such Award shall
not be consummated in whole or in part unless such listing,
registration, qualification, consent, approval or agreement shall
have been effected or obtained free of any conditions not
acceptable to the Committee.

    (l) Rights as Shareholder.  Unless the Plan or the Committee
expressly specifies otherwise, an optionee shall have no rights
as a shareholder with respect to any shares covered by an Award
until the stock certificates representing the shares are actually
delivered to the optionee.  Subject to Sections 3(b) and 6(c), no
adjustment shall be made for dividends or other rights for which
the record date is prior to the date the certificates are
delivered.

    (m) Beneficiary Designation.  The Committee, in its
discretion, may establish procedures for a participant to
designate a beneficiary to whom any amounts payable in the event
of the participant's death are to be paid.

    (n) Additional Plans.  Nothing contained in the Plan shall
prevent the Company, a subsidiary or an affiliate from adopting
other or additional compensation arrangements for its employees
and consultants.

    (o) No Employment Rights.  The adoption of the Plan shall not
confer upon any employee any right to continued employment nor
shall it interfere in any way with the right of the Company, a
subsidiary or an affiliate to terminate the employment of any
employee at any time.

    (p) Rule 16b-3.  Notwithstanding any provision of the Plan,
the Plan shall always be administered, and Awards shall always be
granted and exercised, in such a manner as to conform to the
provisions of Rule 16b-3.

    (q) Governing Law.  The Plan and all Awards shall be governed
by and construed in accordance with the laws of the State of
California.

    (r) Use of Proceeds.  All cash proceeds to the Company under
the Plan shall constitute general funds of the Company.

    (s) Unfunded Status of Plan.  The Plan shall constitute an
"unfunded" plan for incentive and deferred compensation.  The
Committee may authorize the creation of trusts or arrangements to
meet the obligations created under the Plan to deliver Stock or
make payments; provided, however, that unless the Committee
otherwise determines, the existence of such trusts or other
arrangements shall be consistent with the "unfunded" status of
the Plan.

    (t) Assumption by Successor.  The obligations of the Company
under the Plan and under any outstanding Award may be assumed by
any successor corporation, which for purposes of the Plan shall
be included within the meaning of "Company".

    (u) Limitation on Award Grants to Certain Executive Officers.
The Company may not grant Awards under the Plan for more than
500,000 shares to any executive officer whose compensation is
required to be disclosed under Item 402 of Regulation S-K.

SECTION 11.  AMENDMENTS AND TERMINATION.

    The Board may amend, alter or discontinue the Plan or any
Award, but no amendment, alteration or discontinuance shall be
made which would impair the rights of a participant under an
outstanding Award without the participant's consent.  No
amendment, alteration or discontinuance shall require shareholder
approval except (a) an increase in the total number of shares
reserved for issuance pursuant to Awards under the Plan, (b) with
respect to provisions solely as they relate to Incentive Stock
Options, to the extent required for the Plan to comply with
Section 422 of the Code, (c) to the extent required by other
applicable laws, rules or regulations or (d) to the extent that
the Board otherwise concludes that shareholder approval is
advisable.

SECTION 12.  EFFECTIVE DATE OF PLAN.

    The Plan shall be effective on the date it is adopted by the
Board but all Awards shall be conditioned upon approval of the
Plan (a) at a duly held shareholders' meeting by the affirmative
vote of the holders of a majority of the voting power of the
shares of the Company entitled to vote and represented in person
or by proxy at the meeting, or (b) by an action by written
consent of the holders of a majority of the voting power of the
shares of the Company entitled to vote.

SECTION 13.  TERM OF PLAN.

    No Award shall be granted on or after September 30, 2003, but
Awards granted prior to September 30, 2003 may extend beyond that
date.








                     PENEDERM INCORPORATED
                  EMPLOYEE STOCK PURCHASE PLAN


     1.   Purpose

          This Penederm Incorporated Employee Stock Purchase Plan
(the "Plan") is designed to encourage and assist employees of
Penederm Incorporated (the "Company") to acquire an equity
interest in the Company through the purchase of shares of Company
common stock (the "Common Stock").

     2.   Administration

          The Plan shall be administered by the Board of
Directors of the Company (or by a committee of the Board that
will satisfy Rule 16b-3 of the Securities and Exchange Commission
("Rule 16b-3") as in effect with respect to the Company from time
to time, which in either case is referred to as the "Board") in
accordance with Rule 16b-3.  The Board may from time to time
select a committee or persons (the "Administrator"), to be
responsible for any matters so long as such selection comports
with the requirements of Rule 16b-3.  Subject to the express
provisions of the Plan, to the overall supervision of the Board,
and to the limitations of Section 423 of the Internal Revenue
Code of 1986, as amended (the "Code"), the Administrator may
administer and interpret the Plan in any manner it believes to be
desirable, and any such interpretation shall be conclusive and
binding on the Company and all participants.

     3.   Number of Shares

          (a)  The total number of shares of Common Stock
reserved and available for issuance pursuant to this Plan shall
be 150,000.  Such shares may consist, in whole or in part, of
authorized and unissued shares or treasury shares reacquired in
private transactions or open market purchases, but all shares
issued under this Plan shall be counted against the 150,000 share
limitation.

          (b)  In the event of any reorganization,
recapitalization, stock split, reverse stock split, stock
dividend, combination of shares, merger, consolidation, offering
of rights, or other similar change in the capital structure of
the Company, the Board may make such adjustment, if any, as it
deems appropriate in the number, kind, and purchase price of the
shares available for purchase under the Plan and in the maximum
number of shares subject to any option under the Plan.

     4.   Eligibility Requirements

          (a)  Each employee of the Company, except those
described in the next paragraph, shall become eligible to
participate in the Plan in accordance with Section 5 on the first
Enrollment Date on or following commencement of his or her
employment by the Company or following such period of employment
as is designated by the Board from time to time.  Participation
in the Plan is entirely voluntary.

          (b)  The following employees are not eligible to
participate in the Plan:

               (i)  employees who would, immediately upon
enrollment in the Plan, own directly or indirectly (including
options or rights to acquire stock possessing) five percent or
more of the total combined voting power or value of all classes
of stock of the Company or any subsidiary of the Company; and

              (ii)  employees who are customarily employed by the
Company less than 20 hours per week or less than five months in
any calendar year.

          (c)  "Employee" shall mean any individual who is an
employee of the Company or a Participating Subsidiary within the
meaning of Section 3401(c) of the Code and the Treasury
Regulations thereunder.  "Subsidiary" shall mean any corporation
described in Section 424(e) or (f) of the Code.  "Participating
Subsidiary" shall mean a subsidiary which has been designated by
the Administrator as covered by the Plan.

     5.   Enrollment

          Any eligible employee may enroll or re-enroll in the
Plan each year as of the first trading day of (i) July 1995,
(ii) the sixth month following such month, and (iii) each yearly
anniversary of such months (e.g. any January and July), or such
other days as may be established by the Board from time to time
(the "Enrollment Dates").  In order to enroll, an eligible
employee must complete, sign, and submit to the Company an
enrollment form.  Any enrollment form received by the Company by
the 15th day of the month preceding an Enrollment Date (or by the
Enrollment Date in the case of employees hired after such 15th
day), or such other date established by the Administrator from
time to time, will be effective on that Enrollment Date.  For
purposes of the Plan, a "trading day" is any day on which regular
trading occurs on any established stock exchange or market system
on which the Common Stock is traded.

     6.   Grant of Option on Enrollment

          (a)  Enrollment or re-enrollment by a participant in
the Plan on an Enrollment Date will constitute the grant by the
Company to the participant of an option to purchase shares of
Common Stock from the Company under the Plan.  Any participant
whose option expires and who has not withdrawn from the Plan will
automatically be re-enrolled in the Plan and granted a new option
on the Enrollment Date immediately following the date on which
the option expires.

          (b)  Except as provided in Section 9, each option
granted under the Plan shall have the following terms:

               (i)  each option granted under the Plan will have
a term of not more than 24 months or such shorter option period
as may be established by the Board from time to time;
notwithstanding the foregoing, however, whether or not all shares
have been purchased thereunder, the option will expire on the
earlier to occur of (A) the completion of the purchase of shares
on the last Purchase Date occurring within 24 months after the
Enrollment Date for such option, or such shorter option period as
may be established by the Board before an Enrollment Date for all
options to be granted on such date or (B) the date on which the
employee's participation in the Plan terminates for any reason;

              (ii)  payment for shares purchased under the option
will be made only through payroll withholding in accordance with
Section 7;

             (iii)  purchase of shares upon exercise of the
option will be effected only on the Purchase Dates established in
accordance with Section 8;

              (iv)  the price per share under the option will be
determined as provided in Section 8;

               (v)  the number of shares available for purchase
under an option will, unless otherwise established by the Board
before an Enrollment Date for all options to be granted on such
date, be determined by dividing $25,000 by the fair market value
of a share of Common Stock on the Enrollment Date and by
multiplying the result by the number of calendar years included
in whole or in part in the period from grant to expiration of the
option;

              (vi)  the option (taken together with all other
options then outstanding under this and all other similar stock
purchase plans of the Company and any subsidiary of the Company,
collectively "Options") will in no event give the participant the
right to purchase shares at a rate per calendar year which
accrues in excess of $25,000 of fair market value of such shares,
determined at the applicable Enrollment Date; and

             (vii)  the option will in all respects be subject to
the terms and conditions of the Plan, as interpreted by the
Administrator from time to time.

     7.   Payroll and Tax Withholding; Use by Company

          (a)  Each participant shall elect to have amounts
withheld from his or her compensation paid by the Company during
the option period, at a rate equal to any whole percentage up to
a maximum percentage as the Board may establish from time to time
before an Enrollment Date.  Compensation includes regular salary
payments, commissions, overtime pay and any other compensation as
may be determined from time to time by the Board of Directors,
but excludes all other payments including, without limitation,
long-term disability or workers compensation payments, car
allowances, employee referral bonuses, relocation payments,
expense reimbursements (including but not limited to travel,
entertainment, and moving expenses), salary gross-up payments,
and non-cash recognition awards.  The participant shall designate
a rate of withholding in his or her enrollment form and may elect
to increase or decrease the rate of contribution effective as of
any Enrollment Date, by delivery to the Company, not later than
15 days before such Enrollment Date, of a written notice
indicating the revised withholding rate.

          (b)  Payroll withholdings shall be credited to an
account maintained for purposes of the Plan on behalf of each
participant, as soon as administratively feasible after the
withholding occurs.  The Company shall be entitled to use the
withholdings for any corporate purpose, shall have no obligation
to pay interest on withholdings to any participant, and shall not
be obligated to segregate withholdings.

          (c)  Upon disposition of shares acquired by exercise of
an option, the participant shall pay, or make provision adequate
to the Company for payment of, all federal, state, and other tax
(and similar) withholdings that the Company determines, in its
discretion, are required due to the disposition, including any
such withholding that the Company determines in its discretion is
necessary to allow the Company to claim tax deductions or other
benefits in connection with the disposition.  A participant shall
make such similar provisions for payment that the Company
determines, in its discretion, are required due to the exercise
of an option, including such provisions as are necessary to allow
the Company to claim tax deductions or other benefits in
connection with the exercise of the option.

     8.   Purchase of Shares

          (a)  On the last trading day of each month immediately
preceding a month containing an Enrollment Date, or on such other
days as may be established by the Board from time to time, prior
to an Enrollment Date for all options to be granted on an
Enrollment Date (each a "Purchase Date"), the Company shall apply
the funds then credited to each participant's payroll
withholdings account to the purchase of whole shares of Common
Stock.  The cost to the participant for the shares purchased
under any option shall be not less than 85 percent of the lower
of:

               (i) the fair market value of the Common Stock on
the Enrollment Date for such option; or

              (ii)  the fair market value of the Common Stock on
that Purchase Date.

The "fair market value" of the Common Stock on a date shall be
the closing price of the Common Stock on such date on any
established stock exchange or market system if the Common Stock
is traded on such an exchange or market system (and the largest
such exchange or market system if the Common Stock is traded on
more than one), if the Common Stock is not so traded then the
mean between the bid and asked prices for Common Stock on such
date as quoted on Nasdaq National Market or reported in The Wall
Street Journal or similar publication if such prices are so
quoted or reported, or the fair market value on such date as
determined by the Administrator if shares of Common Stock are not
so traded, quoted, or reported.

          (b)  Any funds in an amount less than the cost of one
share of Common Stock left in a participant's payroll
withholdings account on a Purchase Date shall be carried forward
in such account for application on the next Purchase Date, and
any additional amount shall be distributed to the participant.

          (c)  If at any Purchase Date, the shares available
under the Plan are less than the number all participants would
otherwise be entitled to purchase on such date, purchases shall
be reduced proportionately to eliminate the deficit.  Any funds
that cannot be applied to the purchase of shares due to such a
reduction shall be refunded to participants as soon as
administratively feasible.

     9.   Withdrawal from the Plan

          A participant may withdraw from the Plan in full (but
not in part) at any time, effective after written notice thereof
is received by the Company.  All funds credited to a
participant's payroll withholdings account shall be distributed
to him or her without interest within 60 days after notice of
withdrawal is received by the Company.  Any eligible employee who
has withdrawn from the Plan may enroll in the Plan again on any
subsequent Enrollment Date in accordance with the provisions of
Section 5.

     10.  Termination of Employment

          Participation in the Plan terminates immediately when a
participant ceases to be employed by the Company for any reason
whatsoever (including death or disability) or otherwise becomes
ineligible to participate in the Plan.  As soon as
administratively feasible after termination, the Company shall
pay to the participant or his or her beneficiary or legal
representative, all amounts credited to the participant's payroll
withholdings account; provided, however, that if a participant
ceases to be employed by the Company because of the commencement
of employment with a Subsidiary of the Company that is not a
Participating Subsidiary, funds then credited to such
participant's payroll withholdings account shall be applied to
the purchase of whole shares of Common Stock at the next Purchase
Date, and any funds remaining after such purchase shall be paid
to the participant.

     11.  Designation of Beneficiary

          (a)  Each participant may designate one or more
beneficiaries in the event of death and may, in his or her sole
discretion, change such designation at any time.  Any such
designation shall be effective upon receipt in written form by
the Company and shall control over any disposition by will or
otherwise.

          (b)  As soon as administratively feasible after the
death of a participant, amounts credited to his or her account
shall be paid in cash to the designated beneficiaries or, in the
absence of a designation, to the executor, administrator, or
other legal representative of the participant's estate.  Such
payment shall relieve the Company of further liability with
respect to the Plan on account of the deceased participant.  If
more than one beneficiary is designated, each beneficiary shall
receive an equal portion of the account unless the participant
has given express contrary written instructions.

     12.  Assignment

          (a)  The rights of a participant under the Plan shall
not be assignable by such participant, by operation of law or
otherwise.  No participant may create a lien on any funds,
securities, rights, or other property held by the Company for the
account of the participant under the Plan, except to the extent
that there has been a designation of beneficiaries in accordance
with the Plan, and except to the extent permitted by the laws of
descent and distribution if beneficiaries have not been
designated.

          (b)  A participant's right to purchase shares under the
Plan shall be exercisable only during the participant's lifetime
and only by him or her, except that a participant may direct the
Company in the enrollment form to issue share certificates to the
participant and his or her spouse in community property, to the
participant jointly with one or more other persons with right of
survivorship, or to certain forms of trusts approved by the
Administrator.

     13.  Administrative Assistance

          If the Administrator in its discretion so elects, it
may retain a brokerage firm, bank, or other financial institution
to assist in the purchase of shares, delivery of reports, or
other administrative aspects of the Plan.  If the Administrator
so elects, each participant shall be deemed upon enrollment in
the Plan to have authorized the establishment of an account on
his or her behalf at such institution.  Shares purchased by a
participant under the Plan shall be held in the account in the
name in which the share certificate would otherwise be issued
pursuant to Section 12(b).

     14.  Costs

          All costs and expenses incurred in administering the
Plan shall be paid by the Company, except that any stamp duties
or transfer taxes applicable to participation in the Plan may be
charged to the account of such participant by the Company.  Any
brokerage fees for the purchase of shares by a participant shall
be paid by the Company, but brokerage fees for the resale of
shares by a participant shall be borne by the participant.

     15.  Equal Rights and Privileges

          All eligible employees shall have equal rights and
privileges with respect to the Plan so that the Plan qualifies as
an "employee stock purchase plan" within the meaning of Section
423 of the Code and the related Treasury Regulations.  Any
provision of the Plan which is inconsistent with Section 423 of
the Code shall without further act or amendment by the Company or
the Board be reformed to comply with the requirements of Section
423.  This Section 16 shall take precedence over all other
provisions of the Plan.

     16.  Applicable Law

          The Plan shall be governed by the substantive laws
(excluding the conflict of laws rules) of the State of
California.

     17.  Modification and Termination

          (a)  The Board may amend, alter, or terminate the Plan
at any time, including amendments to outstanding options.  No
amendment shall be effective unless within 12 months after it is
adopted by the Board, it is approved by the holders of a majority
of the votes cast at a duly held stockholders' meeting at which a
quorum of the voting power of the Company is represented in
person or by proxy, if such amendment would:

               (i)  increase the number of shares reserved for
purchase under the Plan; or

               (ii) require stockholder approval in order to
comply with SEC Rule 16b-3.

          (b)  In the event the Plan is terminated, the Board may
elect to terminate all outstanding options either immediately or
upon completion of the purchase of shares on the next Purchase
Date, or may elect to permit options to expire in accordance with
their terms (and participation to continue through such
expiration dates).  If the options are terminated prior to
expiration, all funds contributed to the Plan that have not been
used to purchase shares shall be returned to the participants as
soon as administratively feasible.

          (c)  In the event of the sale of all or substantially
all of the assets of the Company or the Company, or the merger of
the Company or the Company with or into another corporation, or
the  dissolution or liquidation of the Company, a Purchase Date
shall occur on the trading day immediately preceding the date of
such event, unless otherwise provided by the Board in its sole
discretion, including provision for the assumption or
substitution of each option under the Plan by the successor or
surviving corporation, or a parent or subsidiary thereof.

     18.  Rights as an Employee

          Nothing in the Plan shall be construed to give any
person the right to remain in the employ of the Company or to
affect the Company's right to terminate the employment of any
person at any time with or without cause.


     19.  Rights as a Stockholder; Delivery of Certificates

          Unless otherwise determined by the Board, certificates
evidencing shares purchased on any Purchase Date shall be
delivered to participants as soon as administratively feasible.
Participants shall be treated as the owners of their shares
effective as of the Purchase Date.





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