PENEDERM INC
DEF 14A, 1998-04-29
PHARMACEUTICAL PREPARATIONS
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                       SCHEDULE 14A
                      (Rule 14a-101)

           INFORMATION REQUIRED IN PROXY STATEMENT


                 SCHEDULE 14A INFORMATION
       Proxy Statement Pursuant to Section 14(a) of the
     Securities Exchange Act of 1934 (Amendment No. ____)


Filed by the Registrant [X]
Filed by a Party other than the Registrant [  ]
Check  the appropriate box:
[  ]      Preliminary Proxy Statement
[  ]      Confidential, for use of the Commission Only (as
          permitted by Rule 14a-6(e)(2))
[X]       Definitive Proxy Statement
[  ]      Definitive Additional Materials
[  ]      Soliciting Material Pursuant to Rule 14a-11(c) or
          Rule 14a-12


                          PENEDERM INCORPORATED
          (Name of Registrant as Specified in Its Charter)

                          PENEDERM INCORPORATED
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):
[X]       No fee required.
[  ]      Fee computed on table below per Exchange Act Rules
          14a-6(i)(4) and 0-11.

    1)  Title of each class of securities to which transaction applies:


___________________________________________________________


    2)  Aggregate number of securities to which transaction applies:


___________________________________________________________


    3)  Per unit price or other underlying value of transaction
        computed pursuant to Exchange Act Rule 0-11:  *


___________________________________________________________


     4) Proposed maximum aggregate value of transaction:


___________________________________________________________


     5) Total fee paid:


___________________________________________________________


[  ] Fee paid previously with preliminary materials.

[  ] Check box if any part of the fee is offset as provided
     by Exchange Act Rule 0-11(a)(2) and identify the filing for
     which the offsetting fee was paid previously.  Identify the
     previous filing by registration statement number, or the Form or
     Schedule and the date of its filing.

     1) Amount Previously Paid:
     2) Form, Schedule or Registration Statement No.:
     3) Filing Party:
     4) Date Filed:




                               
                      PENEDERM INCORPORATED
                                
                       __________________
                                
            NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                                
                          June 24, 1998
                                
TO THE STOCKHOLDERS OF PENEDERM INCORPORATED:

     NOTICE   IS   HEREBY  GIVEN  that  the  Annual  Meeting   of
Stockholders  of  Penederm Incorporated, a  Delaware  corporation
(the  "Company"),  will be held on Wednesday, June  24,  1998  at
10:00  a.m.,  Pacific time, at the Westin Hotel -  San  Francisco
Airport,  1  Bayshore  Highway,  Millbrae,  California,  for  the
following purposes:

     1.   To  elect  directors to serve for the ensuing year  and
          until their successors are elected.
          
     2.   To  approve  an amendment to the Penederm  Incorporated
          1994   Nonemployee  Directors  Stock  Option  Plan   to
          increase  by  150,000 the number of  shares  of  Common
          Stock reserved for issuance thereunder.
          
     3.   To  transact  such other business as may properly  come
          before the meeting or any adjournments thereof.
          
     The foregoing items of business are more fully described  in
the Proxy Statement accompanying this Notice.

     Only  stockholders  of record at the close  of  business  on
April 27, 1998 (the "Record Date") are entitled to notice of, and
to vote at, the meeting and any adjournments thereof.

     All stockholders are cordially invited to attend the meeting
in  person.  Any stockholder attending the meeting  may  vote  in
person even if such stockholder previously signed and returned  a
proxy.

                              FOR THE BOARD OF DIRECTORS
                              
                              
                              
                              Lloyd H. Malchow
                              President and Chief Executive Officer
                              


Foster City, California
May 11, 1998

     
     
     WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE
COMPLETE, DATE AND SIGN THE ENCLOSED PROXY AND MAIL IT PROMPTLY
IN THE ENCLOSED ENVELOPE IN ORDER TO ASSURE REPRESENTATION OF
YOUR SHARES.




                      PENEDERM INCORPORATED
                                
                       __________________
                                
            NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                                
     The  enclosed Proxy is solicited on behalf of the  Board  of
Directors  (the "Board") of Penederm Incorporated (the "Company")
for  use  at  the  Company's Annual Meeting of Stockholders  (the
"Annual  Meeting") to be held Wednesday, June 24, 1998  at  10:00
a.m.,  Pacific  time,  or  at  any  adjournment  or  postponement
thereof,   for  the  purposes  set  forth  herein  and   in   the
accompanying Notice of Annual Meeting of Stockholders. The Annual
Meeting will be held at the Westin Hotel - San Francisco Airport,
1 Bayshore Highway, Millbrae, California. The Company's principal
executive offices are located at 320 Lakeside Drive, Foster City,
California 94404.  The telephone number at that address is  (650)
358-0100.

     These  proxy solicitation materials were mailed on or  about
May  11, 1998 to all stockholders entitled to vote at the  Annual
Meeting.

         INFORMATION CONCERNING SOLICITATION AND VOTING
                                
Record Date and Shares Outstanding

     Stockholders of record at the close of business on April 27,
1998  (the "Record Date") are entitled to notice of, and to  vote
at, the Annual Meeting.  At the Record Date, 8,365,270 shares  of
the  Company's  Common  Stock, par value  $0.01  per  share  (the
"Common Stock"), were issued, outstanding and entitled to vote at
the  Annual Meeting.  Holders of Common Stock are entitled to one
vote for each share of Common Stock held.  In order to constitute
a  quorum  for  conduct  of business at  the  Annual  Meeting,  a
majority  of  the outstanding shares of Common Stock entitled  to
vote  at  the  Annual Meeting must be represented at  the  Annual
Meeting.

Revocability of Proxies

     Any proxy given pursuant to this solicitation may be revoked
by  the person giving it at any time before its use by delivering
to the Secretary of the Company a written notice of revocation or
a  duly  executed proxy bearing a later date or by attending  the
Annual  Meeting  and voting in person.  Mere  attendance  at  the
Annual Meeting will not serve to revoke a proxy.

Voting and Solicitation

     Shares  represented by proxies that reflect  abstentions  or
broker  non-votes will be counted as shares that are present  and
entitled  to vote for purposes of determining the presence  of  a
quorum.   Directors  will be elected by a  favorable  vote  of  a
plurality  of the shares of voting stock present and entitled  to
vote, in person or by proxy, at the Annual Meeting.  Accordingly,
abstentions  or broker non-votes as to the election of  directors
will  not  affect  the election of the candidates  receiving  the
plurality  of  votes.  All other proposals  to  come  before  the
Annual  Meeting require the approval of a majority of the  shares
of  stock  having  voting power present.   Abstentions  as  to  a
particular  proposal will have the same effect as  votes  against
the  proposal.   Broker non-votes, however, will  be  treated  as
unvoted  for the purpose of determining approval of such proposal
and will not be counted as votes for or against such proposal.

     Solicitation  of proxies may be made by directors,  officers
and  other  employees  of  the  Company  by  personal  interview,
telephone,  facsimile or other method. No additional compensation
will  be  paid  for  any  such services. Costs  of  solicitation,
including  preparation, assembly, printing and  mailing  of  this
proxy statement, the proxy and any other information furnished to
the  stockholders, will be borne by the Company.  The Company may
reimburse the reasonable charges and expenses of brokerage houses
or  other  nominees or fiduciaries for forwarding proxy materials
to,  and  obtaining authority to execute proxies from, beneficial
owners for whose account they hold shares of Common Stock.


                          PROPOSAL ONE
                      Election of Directors
                                
Nominees

     The bylaws of the Company provide for a Board consisting  of
not  fewer than five nor more than nine directors.  The  size  of
the Board is set at eight.  Eight directors are to be elected  at
the  Annual  Meeting.  Unless  otherwise  instructed,  the  proxy
holders  will  vote the proxies received by them  for  the  eight
nominees  named  below.   All of the  nominees  named  below  are
presently  directors of the Company and, except  for  Mr.  Smith,
were  elected  to their present term by the stockholders  of  the
Company.  In the event that any nominee is unable or declines  to
serve  as  a  director  at the time of the  Annual  Meeting,  the
proxies will be voted for any nominee who shall be designated  by
the  present Board to fill the vacancy.  The Board has no  reason
to  believe that any of the persons named below will be unable or
unwilling to serve as a director if elected.

     The term of office of each person elected as a director will
continue  until the next Annual Meeting of Stockholders or  until
his successor has been elected and qualified.

     The  name  of  and certain other information regarding  each
nominee is set forth in the table below.

                                                                  Director   
  Name of Nominee            Age      Position with the Company     Since
- -------------------------    ---      -------------------------   --------     
David E. Collins              64      Chairman of the Board         1994
Lloyd H. Malchow              44      Director, President and       1993
                                        Chief Executive Officer
Robert F. Allnutt             62      Director                      1996
William I. Bergman            66      Director                      1991
Mark J. Gabrielson            42      Director                      1996
Harvey S. Sadow, Ph.D.        75      Director                      1990
Joseph E. Smith.              59      Director                      1998
Gerald D. Weinstein, M.D.     61      Director                      1987
     
     There is no family relationship between any of the directors
or  executive officers of the Company.  The Restated  Certificate
of  Incorporation  and bylaws of the Company  contain  provisions
eliminating  or limiting the personal liability of directors  for
violations of a director's fiduciary duty to the extent permitted
by the Delaware General Corporation Law.

     Mr.  Collins  was  appointed Chairman of the  Board  of  the
Company effective January 1, 1997 and served as a director  since
December  1994.   From 1989 to October 1994, Mr. Collins  was  an
Executive  Vice  President  of Schering  Plough  Corporation  and
President   of  its  Healthcare  Products  Division   until   his
retirement.   Prior  to  his  employment  with  Schering   Plough
Corporation,  he  worked for Johnson & Johnson for  26  years  in
various  capacities  and was a member of its executive  committee
from  1982  through 1988.  Mr. Collins has served as Chairman  of
the  Council  on  Family Health and of the Non-Prescription  Drug
Manufacturers Association.  Mr. Collins is a director of  Calypte
Biomedical,  a prescription diagnostic company; Lander,  Inc.,  a
private consumer products company; and Clainel Enterprises,  Inc.
a private investment company.

     Mr. Malchow has served as President, Chief Executive Officer
and a director of the Company since January 1995.  Prior to that,
he served as the Company's President and Chief Operating Officer,
and as a director from May 1993 through January 1995.  He was the
Vice  President  and  General Manager of the  Herbert  Skin  Care
Division of Allergan, Inc. from 1992 to May 1993.  From  1983  to
1991   Mr.   Malchow  held  various  positions,  including   Vice
President,  Sales  of Allergan Medical Optics (formerly  American
Medical  Optics prior to acquisition by Allergan  in  1985)  and,
most  recently, Vice President for Global Development, Skin Care.
Mr.  Malchow holds a B.A. from Carroll College, a M.A.  from  the
University of Maryland and a M.B.A. from Pepperdine University.

     Mr.  Allnutt  has been a director of the Company  since  May
1996.   Since  February  1995  Mr.  Allnutt  has  been  a  Senior
Counselor at APCO Associates, a public relations firm.  From 1985
to 1995 he was the Executive Vice President of the Pharmaceutical
Manufacturers  Association  (now  PhRMA),  a  trade   association
representing    multinational   research   based   pharmaceutical
companies.  Prior to that, he served for 25 years in a variety of
positions with the Federal government, including Associate Deputy
Administrator  for NASA, Assistant Administrator  of  the  Energy
Research  and Development Administration, Staff Director  of  the
United  States  Senate  Committee on Aeronautics  and  Space  and
Associate  General  Counsel of the United  States  Commission  on
Government  Procurement.  Mr. Allnutt is  a  director  of  Cortex
Pharmaceuticals,  Inc. a development stage neuroscience  company;
and  Cypros Pharmaceuticals, Inc., a drug and diagnostics product
company.

     Mr.  Bergman has been a director of the Company since  March
1991.   Mr.  Bergman served in various positions with Richardson-
Vicks Inc., a personal care products company, from 1952 until  he
retired in 1990.  After Procter & Gamble Co. acquired Richardson-
Vicks Inc., he served as President of Richardson-Vicks U.S.A. and
Vice President of Procter & Gamble Co. until his retirement.  Mr.
Bergman  is  the President and a past Chairman of the Council  on
Family Health and is a past Chairman of the Nonprescription  Drug
Manufacturers Association.  Mr. Bergman is a director  of  ZymeTx
Inc.,  a  private company engaged in research and development  of
human diagnostics.

     Mr.  Gabrielson has been a director of the Company since May
1996.   Since  January 1991 Mr. Gabrielson  has  been  a  general
partner  of  Prince Ventures, L.P., a venture capital  management
firm  that  serves  as  the  general partner  of  Prince  Venture
Partners  III,  L.P.  ("Prince").  Prior to joining  Prince,  Mr.
Gabrielson  served  in  a  variety  of  marketing  and   business
positions   with  SmithKline  Beecham  plc since  July   1978.    Mr.
Gabrielson  is also a director of Inhale Therapeutic  Systems,  a
drug delivery company and a number of private companies.

     Dr.  Sadow has been a director of the Company since February
1990.  He was President and Chief Executive Officer of Boehringer
Ingelheim Corporation, a health care company, from 1971  to  1988
and  of  Boehringer Ingelheim Pharmaceuticals, Inc.,  an  ethical
specialty pharmaceutical company, from 1984 to 1988.  In 1988, he
became  Chairman  of  the  Board  of  both  Boehringer  Ingelheim
Corporation and Boehringer Ingelheim Pharmaceuticals.  He retired
as  Chairman of the Board of both companies in 1990 and continued
serving as a director of both companies until 1993.  Dr. Sadow is
also the Chairman of the Board of Cortex Pharmaceuticals, Inc., a
development   stage   neuroscience   company,   and    Cholestech
Corporation,  a medical diagnostics company, and  a  director  of
Anika  Therapeutics,  Inc., a hyaluronic acid  research  company,
Trega  Biosciences,  Inc., a public drug discovery  company,  and
several privately-held health care related companies.  Dr.  Sadow
served as the President of the Connecticut Academy of Science and
Engineering.

     Mr.  Smith has been a director of the Company since February
1998.   Mr.  Smith served in various senior management  positions
with  Warner-Lambert Company from March 1989 until he retired  in
September  1997,  including Corporate Vice President  of  Warner-
Lambert  and  President of its Pharmaceuticals  Division  (Parke-
Davis).   Prior  to  joining Warner-Lambert  Company,  Mr.  Smith
worked  for  Rorer  Pharmaceutical Corporation as  president  for
three  years and before that he worked for Johnson & Johnson  for
21  years  in  various capacities.  Mr. Smith is  a  director  of
VIVUS,  Inc.,  a pharmaceutical company, Boren, Lepore,  Inc.,  a
company  that  provides  outsourced  promotional,  marketing  and
educational  services to the pharmaceutical industry,  and  Senus
Corp.,  a  privately-held biotechnology company.  Mr. Smith  also
serves  on  the Board of Trustees of the International  Longevity
Center.  Mr. Smith earned his MBA degree from the Wharton  School
of the University of Pennsylvania.

     Dr.  Weinstein is a founder of the Company and  has  been  a
director  since inception.  He is a co-inventor of the technology
underlying  the  Company's  TopiCare  Delivery  Compounds.    Dr.
Weinstein  has been the Chairman of the Department of Dermatology
at  the  University  of California, Irvine, College  of  Medicine
since 1979.  Dr. Weinstein is a staff member at the University of
California,  Irvine  Medical Center, the Veterans  Administration
Hospital in Long Beach, California and the Irvine Medical Center.
Dr. Weinstein received a B.A. from the University of Pennsylvania
and  a  M.D.  from  the  University  of  Pennsylvania  School  of
Medicine.

Board Meetings and Committees

     The  Board  held a total of six meetings during  the  fiscal
year ended December 31, 1997.  No director attended fewer than 75
percent of the aggregate of all meetings of the Board and of  the
committees, if any, upon which such director served.

     The  Audit  Committee currently consists of Mr. Collins  and
Dr. Sadow.  The principal functions of the Audit Committee are to
recommend  engagement of the Company's independent  auditors,  to
consult with the Company's auditors concerning the scope  of  the
audit  and  to review with them the results of their examination,
to  review  and  approve any material accounting  policy  changes
affecting  the  Company's operating results  and  to  review  the
Company's financial control procedures and personnel.  The  Audit
Committee held one meeting during fiscal 1997.

     The  Compensation Committee currently consists of Dr. Sadow,
Mr.  Bergman  and  Dr.  Weinstein.   The  Compensation  Committee
determines compensation and benefits for the Company's  executive
officers  and  administers the Company's equity incentive  plans.
The  Compensation  Committee, which consists  solely  of  outside
directors    ineligible   to   participate   in   the   Company's
discretionary  employee stock programs, has  sole  and  exclusive
authority to grant stock options to officers and to directors who
are   also   employees  or  consultants  of  the  Company.    The
Compensation Committee held one meeting during fiscal 1997.

     The Board does not have a nominating committee.

Compensation of Directors

     The Company pays directors' fees to each director who is not
an  employee  of, nor an affiliate of investors in, the  Company.
During  fiscal 1997, the individuals who served as such directors
during that period received fees of $6,200  for their services as
directors except for Dr. Weinstein who received $12,000  pursuant
to  a  consulting arrangement with the Company in  lieu  of  such
fees.   As a result of an  increase in  board fees  put in effect
in  June 1997,  the  Company   expects  to  pay  $10,000  to each 
outside   director  in  fiscal  1998  for  service  on the Board.   
In  addition,   the   Penederm   Incorporated   1994  Nonemployee  
Directors    Stock    Option    Plan    (the  "Directors   Plan")
provides that when a person who is not, and has not been  in  the
preceding twelve months, an officer or an employee of the Company
and  who has not previously been a member of the Board is elected
or  appointed a member of the Board, the Company will grant  that
person  on the effective date of such election or appointment  an
option  to purchase 10,000 shares of the Company's Common  Stock.
The Directors Plan further provides that at the first meeting  of
the   Board   immediately  following  the   annual   meeting   of
stockholders  of  the Company, the Company  will  grant  to  each
nonemployee  director then in office (other  than  a  nonemployee
director who received an initial option grant under the Directors
Plan  on  or  after the record date for that annual  meeting)  an
option  to  purchase  10,000 shares of Common  Stock,  or  15,000
shares in the case of the Chairman of the Board.  Options granted
under  the  Directors Plan vest over one year from  the  date  of
grant  and are fully exercisable on the first anniversary of  the
option grant.  The exercise price of option grants made under the
Directors  Plan is equal to the fair market value of  the  Common
Stock on the date of grant.

                           MANAGEMENT
                                
Security Ownership of Certain Beneficial Owners and Management

     The following table sets forth certain information regarding
beneficial ownership of the Common Stock as of April 27, 1998 (i)
by  each  person who is known by the Company to own  beneficially
more  than  5  percent of the Common Stock, (ii) by each  of  the
Company's  directors,  (iii) by each of the  Company's  executive
officers  named  in  the  Summary Compensation  Table  under  the
caption  "Executive Compensation" below and (iv) by all directors
and executive officers as a group.

                                                          
                                                                       
                                             Number of     Percentage of        
                                              Shares          Shares       
                                           Beneficially    Beneficially
                   Name                      Owned (1)     Owned (1) (2)
                                                          
FRANKLIN RESOURCES, INC. (3)               1,439,300          17.2%
777 Mariners Island Blvd.                                      
San Mateo, California 94404                                    
Charles B. Johnson                         1,439,300          17.2
Rupert H. Johnson, Jr.                     1,439,300          17.2
Franklin Advisers, Inc.                    1,434,400          17.1
SAFECO CORPORATION                         1,450,467          17.3
Safeco Plaza                                                   
Seattle, Washington 98185                                      
SAFECO ASSET MANAGEMENT(4)                 1,312,967          15.7
  Safeco Plaza                                            
  Seattle, Washington 98185                               
SAFECO COMMON STOCK TRUST (5)                792,500           9.5
Safeco Plaza                                                   
Seattle, Washington 98185                                      
SAFECO RESOURSES SERIES TRUST(6)             520,467           6.2
Safeco Plaza                                                   
Seattle, Washington 98185                                      
Mark J. Gabrielson (7)                       287,591           3.4
Lloyd H. Malchow(8)                          359,840           4.1
John W. Quigley, Jr., Ph.D.(9)               137,333           1.6
William Gutshall(10)                          61,000            *
Edward Ebbers(11)                             58,771            *
Michael A. Bates (12)                         63,949            *
Gerald D. Weinstein, M.D.(13)                 55,225            *
David E. Collins(14)                          47,500            *
William I. Bergman(15)                        35,000            *
Harvey S. Sadow, Ph.D.(16)                    37,500            *
Robert F. Allnutt (17)                        18,500            *
Joseph E. Smith (18)                           3,369            *
All directors and executive officers as    1,165,578          12.7%
a group (12 persons)(19)                                  
_______________

*  Less than one percent.

(1)  This  table is based upon information supplied by directors,
     officers  and  certain principal stockholders,  as  well  as
     information  included in Securities and Exchange  Commission
     filings made by principal stockholders and other third party
     sources.   Unless  otherwise indicated in the  footnotes  to
     this  table and subject to the community property laws where
     applicable, each of the stockholders named in this table has
     sole  voting and investment power with respect to the shares
     shown.  Percentage of ownership is based on 8,365,270 shares
     of Common Stock outstanding as of April 27, 1998.
     
(2)  Shares  issuable  upon exercise of outstanding  options  are
     considered  outstanding  for  purposes  of  calculating  the
     percentage  of  Common  Stock of  the  person  holding  such
     options,  but  are not deemed outstanding for computing  the
     percentage of ownership of any other person.
     
(3)  The  shares are reported to be beneficially owned by one  or
     more  investment companies or other managed  accounts  which
     are  advised by Franklin Advisers, Inc. ("FAI") which is  an
     investment  advisory subsidiary of Franklin Resources,  Inc.
     ("FRI"). FAI reports sole voting and dispositive power  over
     the  shares.  Charles B. Johnson and Rupert H. Johnson,  Jr.
     (the "Principal Stockholders") report that they each own  in
     excess of 10% of the outstanding common stock of FRI.   FRI,
     the  Principal  Stockholders  and  FAI  disclaim  beneficial
     ownership of the shares.
     
(4)  SAFECO   Common  Stock  Trust  reports  shared  voting   and
     dispositive power for the shares shown.
     
(5)  SAFECO  Asset  Management  Company  and  SAFECO  Corporation
     indicate  shared voting and dispositive power  and  disclaim
     beneficial ownership of the shares shown, reporting that the
     shares  are  owned  by registered investment  companies  for
     which they serve as advisor.
     
(6)  SAFECO  Resources  Series Trust reports  shares  voting  and
     dispositive power for the shares shown.
     
(7)  Includes 270,091 shares held by Prince Venture Partners III,
     L.P. and 17,500 shares issuable upon exercise of outstanding
     options.   Mr. Gabrielson is the general partner  of  Prince
     Ventures  and the general partner of Prince Venture Partners
     III, L.P.
     
(8)  Includes   352,000   shares  issuable   upon   exercise   of
     outstanding options; 159,888 of such shares are not  subject
     to repurchase on or after June 26, 1998.
     
(9)  Includes   130,944   shares  issuable   upon   exercise   of
     outstanding  options; 69,511 of such shares are not  subject
     to repurchase on or after June 26, 1998.
     
(10) Includes 61,000 shares issuable upon exercise of outstanding
     options; 23,582 of such shares are not subject to repurchase
     on or after June 26, 1998.
     
(11) Includes 54,375 shares issuable upon exercise of outstanding
     options; 19,777 of such shares are not subject to repurchase
     on or after June 26, 1998.
     
(12) Includes  59,250  shares  issuable  upon  exercise  of
     outstanding  options; 13,685 of such shares are not  subject
     to repurchase on or after June 26, 1998.
     
(13) Includes 27,500 shares issuable upon exercise of outstanding
     options.
     
(14) Includes 32,500 shares issuable upon exercise of outstanding
     options.
     
(15) Includes 35,000 shares issuable upon exercise of outstanding
     options.
     
(16) Includes 27,500 shares issuable upon exercise of outstanding
     options.
     
(17) Includes 17,500 shares issuable upon exercise of outstanding
     options.
     
(18) Includes  3,369 shares issuable upon exercise of outstanding
     options.
     
(19) Includes   818,438   shares  issuable   upon   exercise   of
     outstanding options; 438,931 of such shares are not  subject
     to repurchase on or after June 26, 1998.
     
Executive Compensation

     The  following  table sets forth the total compensation  for
the  fiscal years ended December 31, 1995, 1996 and 1997  of  the
Chief Executive Officer and each of the executive officers of the
Company  who  served as executive officers at  fiscal  year  end.
None  of  the  named  executive officers earned  any  bonuses  or
compensation for the fiscal years other than as set forth in  the
table or received any restricted stock awards, stock appreciation
rights or long-term incentive plan payouts.

     
     
                   Summary Compensation Table
                       
                                       Annual   Annual    Long-Term   
                                       Compen-  Compen-   Compen-      Other
                                       sation   sation    sation       Compen-
Name and                     Fiscal    Salary   Bonus     Options      sation
Principal Position            Year      ($)      ($)        (#)          (1)
- --------------------------   ------   --------  -------  ----------    ------ 
Lloyd H. Malchow              1997    217,300   38,027        -         3,200
President, Chief Executive    1996    204,555   50,222     155,000      4,492
Officer and Director          1995    195,000   21,840      22,000      4,493
                                                                                
John W. Quigley, Jr., Ph.D.   1997    174,506   24,758         -        3,200
Vice President,               1996    167,349   16,334      49,500      4,492
Research and Development      1995    161,340   11,697       9,000      4,493
                                                                               
Edward Ebbers                 1997    135,830   11,885         -        2,720
Vice President,               1996    127,109   18,565      37,000      3,812
Sales and Marketing           1995    112,000    6,272       6,625      3,356
                                                                               
William Gutshall              1997    122,950   27,290         -        2,460
Vice President,               1996    115,664   15,910      27,000      2,314
Operations                    1995    109,419    7,440      21,000      2,184
                                                                               
Michael A. Bates (2)          1997    102,198   16,288      30,000      2,040
Chief Financial Officer,      1996     85,800    2,983      14,750      2,561
Vice President, Finance       1995     70,000    2,000       8,500      1,797
and Administration
_______________

(1)  This column includes the value of the shares of Common Stock
     contributed  by  the  Company to  each  executive  officer's
     401(k) account under the Penederm Incorporated 401(k)  Plan.
     The  shares are contributed effective as of the last trading
     day  of  the  year and the number of shares contributed  was
     based on the closing price of the Common Stock on that date.
     
(2)  Mr.   Bates  was  appointed  Vice  President,  Finance   and
     Administration as of October 13, 1997.
     

     The following table sets forth certain information regarding
grants  of  stock  options  made during  the  fiscal  year  ended
December 31, 1997 to the executive officers named in the  Summary
Compensation Table.  Since inception, the Company has not granted
any stock appreciation rights.

<TABLE>


                Option Grants in Last Fiscal Year

                                        Individual Grants
                              ------------------------------------------      Potential
                                                                             Realizable
                                          % of                            Value at assumed
                                          Total                             Annual Rates
                                         Options                            Of Stock Price
                                        Granted to                        Appreciation For
                                        Employees    Exer-                 10 Year Option
                             Options    in Fiscal    cise                      Term (4)
                             Granted      Year       Price   Expiration   ------------------
    Name                     (#)(1)        (2)      ($/sh)    Date(3)      5%($)     10%($)
- --------------------------    -------   ----------   ------    --------   --------  ---------- 
<S>                          <C>          <C>        <C>     <C>         <C>        <C> 
Lloyd H. Malchow                --         --          --        --         --         --
John W. Quigley, Jr., Ph.D      --         --          --        --         --         --
Edward Ebbers                   --         --          --        --         --         --
William Gutshall                --         --          --        --         --         --
Michael A. Bates             30,000       29.8%      $12.25  11/10/2007  $231,119   $585,700
_______________

(1)  The  options  included  in this table  are  all  immediately
     exercisable,  but the shares issuable upon  option  exercise
     are  subject  to a right of repurchase by the  Company  upon
     employment  termination, which right of  repurchase  expires
     over a period of five years.
     
(2)  The  total  number  of  options  granted  to  the  Company's
     employees during fiscal year 1997 was 100,800.
     
(3)  The  options are subject to earlier expiration in the  event
     of the officer's termination of employment with the Company.
     
(4)  Potential  realizable value is based on an  assumption  that
     the  market  price of the stock appreciates  at  the  stated
     rate, compounded annually, from the date of grant until  the
     end    of  the  ten-year  option  term.   These  values  are
     calculated   based  on  requirements  promulgated   by   the
     Securities  and Exchange Commission and do not  reflect  the
     Company's estimate of future stock price appreciation.

</TABLE>


     
     The following table sets forth certain information regarding
exercises of stock options during the fiscal year ended  December
31,1997   to   the  executive  officers  named  in  the   Summary
Compensation  Table.   Value realized is  considered  to  be  the
difference between exercise price and market price on the date of
exercise.  Value of unexercised options is considered to  be  the
difference between exercise price and market price of $10.00  per
share on December 31, 1997.


<TABLE>


       Aggregated Option Exercises in Last Fiscal Year and
                  Fiscal Year End Option Values
                                
                                                                             Value of
                                                              Number of     Unexercised
                                                             Unexercised   In-the-Money
                                                             Options at     Options at
                                                             Fiscal Year    Fiscal Year
                                                               End (#)        End($)
                                 Shares                                          
                                Acquired         Value      Exercisable/   Exercisable/
                              On Exercise       Realized    Unexercisable  Unexercisable
Name                              (#)             ($)            (1)
- --------------------------   -------------      --------    -------------  --------------                                          

<S>                           <C>                <C>          <C>           <C>        
Lloyd H. Malchow                 --                --         302,000/0     1,075,750/0
John W. Quigley, Jr., Ph.D       --                --         120,944/0       584,096/0
Edward Ebbers                    --                --          49,375/0        54,109/0
William Gutshall               3,000             $29,200       55,000/0       145,925/0
Michael A. Bates                 --                --          53,250/0        19,903/0
     
_______________

(1)  The  options  included  in this table  are  all  immediately
     exercisable,  but the shares issuable upon  option  exercise
     are  subject  to a right of repurchase by the  Company  upon
     employment  termination, which right of  repurchase  expires
     over a period of time.  At December 31, 1997, the number  of
     In-the-Money  shares  subject  to  repurchase  under   these
     options  and  their value were as follows:  Mr.  Malchow  --
     61,167  shares  having a value of $241,960; Dr.  Quigley  --
     22,168  shares  having  a value of $86,721;  Mr.  Ebbers  --
     13,334  shares  having a value of $40,168; Mr.  Gutshall  --
     17,167  shares having a value of $78,028; and Mr.  Bates  --
     5,250 shares having a value of $11,670.
  
</TABLE>
   
     The  Company did not make any awards during the fiscal  year
ended December 31, 1997 to any of the executive officers named in
the Summary Compensation Table under any long-term incentive plan
providing  compensation  intended  to  serve  as  incentive   for
performance  to occur over a period longer than one fiscal  year,
excluding stock options.

Report of the Compensation Committee of the Board of Directors

     The Compensation Committee is comprised of three independent
nonemployee directors.  As members of the Compensation Committee,
it  is  our responsibility to determine the most effective  total
executive compensation strategy, based upon the business needs of
the  Company  and  consistent  with stockholders'  interests,  to
administer  the Company's executive compensation plans,  programs
and   policies,   to  monitor  corporate  performance   and   its
relationship to compensation of executive officers, and  to  make
appropriate recommendations concerning matters of compensation.

     Compensation Philosophy
     
     The  Company  was  formed in 1987 as a private  company  and
initially offered Common Stock to the public in 1993.  The  major
goals of the compensation program are to align compensation  with
the  attainment  of  key business objectives and  to  enable  the
Company to attract, retain and reward capable executives who  can
contribute  to  the  continued success of  the  Company.   Equity
participation  and a strong alignment to stockholders'  interests
are  key elements of the Company's compensation philosophy.  Four
key  goals  form  the  basis of compensation  decisions  for  all
employees of the Company:

     1.   To   attract  and  retain  the  most  highly  qualified
          management and employee team;
          
     2.   To  pay competitively compared to similar drug delivery
          and   biopharmaceutical  companies   and   to   provide
          appropriate  reward  opportunities for  achieving  high
          levels of performance compared to similar organizations
          in the marketplace;
          
     3.   To  emphasize sustained performance by aligning rewards
          with stockholder interests, especially through the  use
          of equity participation programs; and
          
     4.   To  motivate  executives and employees to  achieve  the
          Company's  annual  and  long-term  business  goals  and
          encourage  behavior  toward the  fulfillment  of  those
          objectives.
          
     As  a  result  of  this philosophy, the Company's  executive
compensation  program  consists of base salary,  incentive  stock
options, performance share awards and standard benefits.

     Base  Salary.   The  Compensation Committee  recognizes  the
importance  of maintaining compensation practices and  levels  of
compensation competitive with drug delivery and biopharmaceutical
companies  in  comparable  stages of development.   For  external
marketplace  comparison  purposes, a group  of  approximately  70
companies  operating in our industry are utilized for determining
competitive compensation levels.

     Base  salary represents the fixed component of the executive
compensation  program.  The Company's philosophy  regarding  base
salaries is conservative, maintaining salaries somewhat below  or
at  approximately the competitive industry median.  Determination
of  base  salary  levels is established on an  annual  review  of
marketplace  competitiveness with similar  biopharmaceutical  and
drug  delivery companies, and on individual performance. Periodic
increases  in  base  salary  relate to  individual  contributions
evaluated  against  established objectives, relative  marketplace
competitiveness  levels, length of service,  and  the  industry's
annual competitive pay practice movement.

     Stock Options.  The Compensation Committee strongly believes
that  one  of  the  important goals of the  compensation  program
should   be   to  provide  key  employees  who  have  significant
responsibility for the management, growth, and future success  of
the  company  with an opportunity to increase their ownership  of
the  Company and potentially gain financially from Company  stock
price  increases.  The interests of stockholders, executives  and
employees should thereby be closely aligned.  Executives and  key
employees  are  eligible to receive stock options  generally  not
more  often  than once a year, giving them the right to  purchase
shares  of Common Stock of the Company in the future at  a  price
equal to fair market value at the date of grant.

     Under  the  Company's  stock option  plans,  shares  of  the
Company's Common Stock may be purchased at the fair market  value
on  the date of grant.  All grants must be exercised according to
the   provisions  of  the  Company's  stock  option  plans.   All
outstanding options expire ten years from the date of grant.

     Performance  Share Awards.  The Compensation Committee  also
believes  that  a  component  of compensation  of  the  executive
management of the Company should be related to the Company's  and
the    executive's    specific  objectives.    Accordingly,   the
Compensation  Committee granted performance share awards  to  the
executive  officers.  These awards consisted of a bonus  computed
based  on a designated percentage of salary, achievement  of  the
Company's  targeted objectives and achievement of the  individual
executive's targeted objectives, and are paid in cash or stock at
the discretion of the Compensation Committee.

     Other  Benefits.   The Company's philosophy  is  to  provide
adequate health- and welfare-oriented benefits to executives  and
employees,  but to maintain a highly conservative  position  with
respect  to executive benefits. The Company provides no executive
benefits.

     1997 Compensation for the Chief Executive Officer

     In  1997, Lloyd Malchow was paid a salary of $217,300.   Mr.
Malchow  was  granted a performance share award  in  early  1997,
which  was  paid in cash during the first quarter of 1998,  based
upon the Compensation Committee's evaluation of the attainment of
the  Company's  and Mr. Malchow's stated objectives.   The  total
cash  compensation paid to Mr. Malchow in 1997  is  approximately
the   industry  median  for  chief  executive  officers  of   the
competitive industry comparative group.

     Summary

     The Compensation Committee believes that the compensation of
executives by the Company is appropriate and competitive with the
compensation    provided    by   other    drug    delivery    and
biopharmaceutical companies with which the Company  competes  for
executives   and   employees.    The   Committee   believes   its
compensation  strategy, principles, and  practices  result  in  a
compensation  program tied to stockholder returns and  linked  to
the   achievement  of  annual  and  longer-term   financial   and
operational  results of the Company on behalf  of  the  Company's
stockholders.

     The Compensation Committee of the Board of Directors

               - William I. Bergman
               - Dr. Harvey S. Sadow
               - Dr. Gerald D. Weinstein
               
Compensation Committee Interlocks and Insider Participation

     The Compensation Committee of the Company currently consists
of Mr. Bergman, Dr. Sadow and Dr. Weinstein.

Certain Relationships and Related Transactions

     Dr. Quigley, Senior Vice President, Research and Development
of  the  Company,  borrowed $125,000 from  the  Company  under  a
promissory  note dated June 15, 1990.  The promissory note  bears
simple  interest at the rate of 8.82 percent per  annum,  payable
quarterly,  and  matures upon the earlier of (i)  demand  by  the
Company,  which  demand may be made at any time  after  June  15,
1992,  or  (ii) termination of Dr. Quigley's employment with  the
Company.  Under an Amended and Restated Pledge Agreement executed
by  Dr.  Quigley and the Company in November 1994, the obligation
under  the  promissory  note  is secured  by  a  portion  of  Dr.
Quigley's options to purchase Common Stock of the Company.

Compliance with Section 16(a) of the Exchange Act

     Section  16(a) of the Securities Exchange Act  of  1934,  as
amended  (the  "Exchange Act"), requires the Company's  directors
and executive officers, and persons who own more than ten percent
of a registered class of the Company's equity securities, to file
reports of ownership on Form 3 and changes in ownership on Form 4
or 5 with the Securities and Exchange Commission and the National
Association of Securities Dealers.  Such officers, directors  and
ten  percent  stockholders are also required  by  Securities  and
Exchange  Commission rules to furnish the Company with copies  of
all Section 16(a) forms that they file.

     Based  solely  on  its  review of  copies  of  such  reports
received   or  written  representations  from  certain  reporting
persons, the Company believes that, during the fiscal year  ended
December  31,  1997,  there has been no failure  by  any  of  its
officers,  directors or ten percent stockholders  to  file  on  a
timely  basis  any  reports required  by  Section  16(a)  of  the
Exchange Act.



Stock Price Performance Graph

     The   following  graph  illustrates  a  comparison  of   the
cumulative  total stockholder return (change in stock price  plus
reinvested  dividends)  of the Company's Common  Stock  with  the
Nasdaq  Stock Market Index (U.S.) (the "Nasdaq Composite  Index")
and  the  CRSP  Nasdaq Pharmaceutical Stock  Index  (the  "Nasdaq
Pharmaceutical  Index").   Although the Securities  and  Exchange
Commission  regulations generally require the graph  to  cover  a
five-year period, the graph below covers a 50-month period  since
the  Company's Common Stock has been publicly traded  only  since
November  3, 1993.  The comparisons in the graph are required  by
the  Securities and Exchange Commission and are not  intended  to
forecast or be indicative of possible future performance  of  the
Company's Common Stock.


<TABLE>

 [EDGAR REPRESENTATION OF DATA POINTS ON STOCK PRICE PERFORMANCE
                             GRAPH]
                                
                               10/29/93                                                   
                               11/3/93   12/31/93   12/30/94   12/29/95   12/31/96   12/31/97
<S>                              <C>        <C>        <C>        <C>        <C>        <C>                                       
 Penederm Incorporated           100        100        57         103        112         91
 Nasdaq Composite Index          100        100        97         138        170        208
 Nasdaq Pharmaceutical Index     100        100        75         137        137        142
                                                                               
</TABLE>
     


     The comparison assumes a $100 investment on November 3, 1993
(the  date  of  the  Company's initial public  offering)  in  the
Company's  Common Stock and on October 29, 1993 in the securities
comprising   the  Nasdaq  Composite  Index  and  the   securities
comprising the Nasdaq Pharmaceutical Index.


                          PROPOSAL TWO
       Approval of Amendment to the Penederm Incorporated
          1994 Nonemployee Directors Stock Option Plan
                                
Background

     The  Board  has  approved, subject to stockholder  approval,
amendment to the Directors Plan as described below.

Description of the Proposal

     Currently,  the  total  number of  shares  of  Common  Stock
reserved and available for issuance pursuant to options under the
Directors Plan is 200,000 shares. The proposed amendment  to  the
Directors  Plan  increases the number of shares of  Common  Stock
reserved for issuance thereunder by 150,000 to 350,000.

Description of the 1994 Nonemployee Directors Stock Option Plan

     Only  nonemployee directors of the Company are  eligible  to
participate  in  the  Directors  Plan.   The  Directors  Plan  is
designed   to  work  automatically.   However,  to   the   extent
administration is necessary, it is provided by the Board  or  the
Board may delegate its authority to a committee of the Board.

     Option grants to nonemployee directors are made on a formula
basis  and not on a discretionary basis.  As currently in effect,
the  Directors Plan provides that when a person who is  not,  and
has  not  been in the preceding twelve months, an officer  or  an
employee of the Company and who has not previously been a  member
of  the Board is elected or appointed a member of the Board,  the
Company  will  grant that person on the effective  date  of  such
election  or appointment a non-qualified stock option (an  "NQO")
to  purchase  10,000 shares of Common Stock.  The Directors  Plan
further  provides  that  on  the  first  meeting  of  the   Board
immediately  following the annual meeting  of  stockholders,  the
Company  shall grant to each nonemployee director then in  office
an  option  to purchase 10,000 shares, or an option  to  purchase
15,000 shares if such nonemployee director is the Chairman of the
Board of the Company.

     Options granted under the Directors Plan vest over one  year
from  the  date of grant and are fully exercisable on  the  first
anniversary  of  option grant.  The Company currently  has  seven
nonemployee  directors  who are eligible to  participate  in  the
Directors  Plan, all of whom have been nominated for election  at
the  Annual  Meeting.   If  the  Directors  Plan  is  amended  as
proposed, the number of shares of Common Stock reserved under the
Directors Plan will increase by 150,000 shares.

     The  consideration  payable in connection  with  any  option
(including any related taxes) may be paid by promissory  note  of
the nonemployee director or by delivery of shares of Common Stock
of the Company.  Options granted under the Directors Plan have  a
term  of  ten  years.  Options generally terminate  three  months
after  a  nonemployee director ceases to be, for  any  reason,  a
director of the Company, but if a nonemployee director ceases  to
be  a director due to death, disability or retirement, the Option
may  be  exercised for two years after the termination.   Options
are  not  transferable, except by gift to a family  member  or  a
partnership or trust for a family member or by will or  the  laws
of descent and distribution.

     The Board may amend, alter or discontinue the Directors Plan
or  any  option  at  any  time, except  that  the  consent  of  a
participant  is  required  if the participant's  existing  rights
under  an outstanding option would be impaired.  In addition,  to
the  extent required under applicable tax and securities laws and
regulations,  the  stockholders of the Company must  approve  any
amendment,  alteration, or discontinuance of the  Directors  Plan
that would increase the total number of shares reserved under the
Directors  Plan and in certain other circumstances as  the  Board
may deem advisable to comply with such laws and regulations.   In
addition, the provisions of the Directors Plan governing  who  is
granted options, the number of shares covered by each option, the
exercise  price, and the period of exercisability and the  timing
of  option  grants may not be amended more than  once  every  six
months,  other  than  for changes to comport  with  the  Internal
Revenue  Code  of 1986, as amended (the "Code") or  the  Employee
Retirement Income Security Act of 1974.

     In  the  event of a "change in control" of the  Company,  as
defined  in  the  Directors Plan, the  vesting  of  options  will
automatically  accelerate.  A "change in control" is  defined  to
include the acquisition of 20 percent or more of the voting power
of  the Company's outstanding stock, a proxy solicitation for one
or  more directors without support of the then-current Board, and
certain  mergers or reorganizations or other changes in ownership
of the Company's assets or stock.

     The  following table shows, based on the current composition
of  the Board and assuming approval of the amendments, the number
of  options which will be granted to the listed groups under  the
Directors  Plan in 1998 and in each year thereafter  until  there
are  no  longer  shares  reserved  for  issuance  or  until  plan
termination.

                                                 
                                                                               
                                                    Number of Options (1)
                                                    ---------------------   
                                                     1998     Thereafter
                                                    ------    -----------       
All executive officers as a group                      0          0
                                                                   
All  directors who are not executive officers       85,000      75,000
as a group                                                         

All employees (other than executive officers)          0          0
as a group                                                         

________________
(1)  All  options granted at fair market value as of the date  of
grant.

     The  Company  believes that in order to attract  and  retain
highly  qualified  candidates  to  serve  as  directors,  it   is
important that directors have meaningful equity ownership in  the
Company.   Initially, the reason for creating a  nondiscretionary
option   plan  for  nonemployee  directors  was  to  permit   the
nonemployee  directors  to act as "disinterested"  administrators
for  the Company's other equity benefit plans under rules of  the
Securities  and  Exchange  Commission (the  "Commission"),  while
still allowing equity participation by the nonemployee directors.
Although   subsequent  rule  changes  by  the   Commission   have
eliminated such "disinterested" administration requirements,  the
Company believes that the automatic and non-discretionary  nature
of the Directors Plan best serves the interests of the Company.

Certain Federal Income Tax Consequences

     THE FOLLOWING SUMMARY OF FEDERAL INCOME TAX CONSEQUENCES  IS
BASED  UPON  EXISTING  STATUTES, REGULATIONS AND  INTERPRETATIONS
THEREOF.   THE  APPLICABLE  RULES ARE  COMPLEX,  AND  INCOME  TAX
CONSEQUENCES MAY VARY DEPENDING UPON THE PARTICULAR CIRCUMSTANCES
OF EACH PLAN PARTICIPANT.  THIS PROXY STATEMENT DESCRIBES FEDERAL
INCOME  TAX CONSEQUENCES OF GENERAL APPLICABILITY, BUT  DOES  NOT
PURPORT  TO  DESCRIBE PARTICULAR CONSEQUENCES TO EACH  INDIVIDUAL
PLAN   PARTICIPANT  OR  FOREIGN,  STATE  OR  LOCAL   INCOME   TAX
CONSEQUENCES,  WHICH  MAY DIFFER FROM THE UNITED  STATES  FEDERAL
INCOME TAX CONSEQUENCES.

     Award;   Exercise.   The  recipient  of   an   Option   (the
"Optionee") is generally not taxable upon the award  of  an  NQO.
The  Optionee will have ordinary income at the time  of  exercise
measured  by  the excess of the fair market value of  the  shares
purchased  upon exercise over the exercise price  of  the  option
(the  "Option Spread") on the exercise date.  The Optionee's  tax
basis  in the shares will be their fair market value on the  date
of  exercise, and the holding period for purposes of  determining
whether  capital  gain or loss upon sale is long-  or  short-term
will begin on that date.

     Sale  of  Option  Shares.   Upon sale,  other  than  to  the
Company,  of  shares acquired under a NQO, an Optionee  generally
will  recognize  capital  gain or  loss  to  the  extent  of  the
difference between the sale price and the Optionee's tax basis in
the  shares,  which  will  be  long-term  gain  or  loss  if  the
optionee's  holding period in the shares is more than  one  year.
If stock is sold to the Company rather than to a third party, the
sale  may not produce capital gain or loss.  A sale of shares  to
the  Company  will constitute a redemption of such shares,  which
could  be  taxable  as a dividend unless the redemption  is  "not
necessarily equivalent to a dividend" within the meaning  of  the
Code.

     Exercise with Stock.  If an Optionee tenders Common Stock to
pay all or part of the exercise price of a NQO, the Optionee will
not  have  a  taxable gain or deductible loss on the  surrendered
shares.  Instead, shares acquired upon exercise that are equal in
value  to  the  fair  market value of the shares  surrendered  in
payment  are  treated  as if they had been  substituted  for  the
surrendered shares, taking as their basis and holding period  the
basis and holding period that the Optionee had in the surrendered
shares.   The  additional shares are taxable to the optionee  and
are  treated as newly acquired with a basis equal to  their  fair
market value on the exercise date.

     Special Federal Income Tax Consideration Due to Short  Swing
Profit  Rule.   The  potential liability of a person  subject  to
Section 16 of the Securities Exchange Act of 1934 to repay short-
swing  profits from the resale of shares acquired under a Company
plan  constitutes  a "substantial risk of forfeiture,"  which  is
treated as lapsing at such time as the potential liability  under
Section  16  lapses.  If the shares are subject to a  substantial
risk  of  forfeiture  and the Optionee files  an  election  under
Section 83(b) of the Code ("Section 83(b) Election") with respect
to the shares, the Optionee will have ordinary income at the time
of  exercise as described above.  If the shares are subject to  a
substantial  risk of forfeiture and no Section 83(b) Election  is
filed,  the  Optionee  will  not be taxable  upon  exercise,  but
instead  will  have ordinary income, on the date the restrictions
lapse,  in  an amount equal to the difference between the  amount
paid  for the shares under the option and their fair market value
as  of  the  date  of lapse; in addition, the Optionee's  holding
period  will  begin  on the date of lapse.   Persons  subject  to
Section  16 who would be required by Section 16 to repay  profits
from  the immediate resale of stock acquired under a Company plan
should  consider whether to file a Section 83(b) Election at  the
time  they acquire stock under a Company plan in order  to  avoid
deferral  of the date that they are deemed to acquire shares  for
federal income tax purposes.

Proposal

     Stockholders are being asked to approve the amendment to the
Directors  Plan.   The  affirmative vote  of  the  holders  of  a
majority  of  the outstanding shares of the Common Stock  of  the
Company  represented and voting at the Annual Meeting is required
to adopt the amendment to the Directors Plan.

Board Recommendation

     The Board recommends a vote "FOR" approval of the proposal.

                      INDEPENDENT AUDITORS
                                
     The  Board  has  selected Ernst & Young LLP  as  independent
auditors to audit the financial statements of the Company for the
1998  fiscal  year.  Ernst & Young LLP has been  engaged  as  the
Company's auditors since 1995.  Representatives of Ernst &  Young
LLP  are  expected to be present at the Annual Meeting  and  will
have an opportunity to make a statement if they desire to do  so.
The  representatives of Ernst & Young LLP also will be  available
to respond to questions raised during the meeting.

                      STOCKHOLDER PROPOSALS
                                
     Proposals of stockholders of the Company which are  intended
to  be  presented  at the Company's 1999 meeting of  stockholders
must  be  received by the Secretary of the Company no later  than
January  11, 1999 in order to be included in the proxy soliciting
material relating to that meeting.

                          OTHER MATTERS
                                
     The Company knows of no other matters to be submitted at the
Annual  Meeting.  If any other matters properly come  before  the
Annual  Meeting, it is the intention of the persons named in  the
enclosed proxy to vote the shares they represent as the Board may
recommend.

                              THE BOARD OF DIRECTORS
                              
Dated: May 11, 1998




                     Penederm Incorporated
PROXY                                                  PROXY
               THIS PROXY IS SOLICITED ON BEHALF
                   OF THE BOARD OF DIRECTORS

     The undersigned hereby appoint(s) Lloyd H. Malchow and
Michael A. Bates, or either of them, each with full power of
substitution, the lawful attorneys and proxies of the undersigned
to vote as designated below, and, in their discretion, upon such
other business as may properly be presented to the meeting, all
of the shares of PENEDERM INCORPORATED which the undersigned
shall be entitled to vote at the Annual Meeting of Stockholders
to be held on June 24, 1998, and at any adjournments or
postponements thereof.

      1.  To elect as directors David E. Collins, Lloyd H.
Malchow, Robert F. Allnutt, William I. Bergman, Mark J.
Gabrielson, Harvey S. Sadow, Ph.D., Joseph E. Smith and Gerald D.
Weinstein.

          [ ]  FOR all nominees listed (except as indicated
below)

          [ ]  WITHHOLD AUTHORITY to vote (as to all nominees)

     To withhold authority to vote for any individual nominee,
write that nominee's name on the line provided below:
    _______________________________________________________

      2.  To approve an amendment to the Penederm Incorporated
1994 Nonemployee Directors Stock Option Plan to increase by
150,000 the number of shares of Common Stock reserved for
issuance thereunder.

          [ ]  FOR  [  ]  AGAINST  [  ]  ABSTAIN


     This proxy, when properly executed, will be voted in the
manner directed by the undersigned shareholder.  WHEN NO CHOICE
IS INDICATED, THIS PROXY WILL BE VOTED FOR THE NOMINEES OR
PROPOSALS LISTED ABOVE..  This proxy may be revoked at any time
prior to the time it is voted by any means described in the
accompanying Proxy Statement.

                              _______________________________
                                       (Signature)

                              _______________________________
                                       (Signature)

                              Please  date and sign exactly as 
                              name(s) appear(s) hereon. If shares 
                              are held jointly, each holder should
                              sign.  Please give full title and
                              capacity in which signing if not
                              signing as an individual.

                              Dated:  _______________, 1998

PLEASE COMPLETE, DATE AND SIGN THIS PROXY AND MAIL IT PROMPTLY IN
THE ENCLOSED ENVELOPE TO ASSURE REPRESENTATION OF YOUR SHARES.





                                   
                                                         APPENDIX A



                      PENEDERM INCORPORATED
                  1994 NONEMPLOYEE DIRECTORS
                        STOCK OPTION PLAN


     1.   Purpose.

          The purpose of this Plan is to offer Nonemployee
Directors of Penederm Incorporated an opportunity to acquire a
proprietary interest in the success of the Company, or to
increase such interest, by purchasing shares of the Company's
Common Stock.  This Plan provides for the grant of Options to
purchase Shares.  Options granted hereunder shall be
"Nonstatutory Options," and shall not include "incentive stock
options" intended to qualify for treatment under Sections 421 and
422 of the Internal Revenue Code of 1986, as amended.

     2.   Definitions.

          As used herein, the following definitions shall apply:

          (a)  "Administrator" shall mean the entity, either the
Board or the committee of the Board, responsible for
administering this Plan, as provided in Section 3.

          (b)  "Affiliate" means a parent or subsidiary
corporation as defined in the applicable provisions (currently,
Sections 424(e) and (f), respectively) of the Code.

          (c)  "Board" shall mean the Board of Directors of the
Company, as constituted from time to time.

          (d)  "Change in Control" shall mean the occurrence of
any one of the following:

               (i)  any "person", as such term is used in
Sections 13(d) and 14(d) of the Exchange Act (other than the
Company, an Affiliate, or a Company employee benefit plan,
including any trustee of such plan acting as trustee) is or
becomes the "beneficial owner" (as defined in Rule 13d-3 under
the Exchange Act), directly or indirectly, of securities of the
Company representing 20% or more of the combined voting power of
the Company's then outstanding securities;

               (ii)  the solicitation of proxies (within the
meaning of Rule 14a-1(k) under the Exchange Act and any successor
rule) with respect to the election of any director of the Company
where such solicitation is for any candidate who is not a
candidate proposed by a majority of the Board in office prior to
the time of such election; or

               (iii)  the dissolution or liquidation (partial or
total) of the Company or a sale of assets involving 30% or more
of the assets of the Company, or any merger or reorganization of
the Company, whether or not another entity is the survivor, or
other transaction pursuant to which the holders, as a group, of
all of the shares of the Company outstanding prior to the
transaction hold, as a group, less than 70% of the shares of the
Company outstanding after the transaction.

          (e)  "Code" shall mean the Internal Revenue Code of
1986, as amended from time to time, and any successor statute.

          (f)  "Company" shall mean Penederm Incorporated, a
California corporation.

          (g)  "Common Stock" shall mean the Common Stock of the
Company.

          (h)  "Disability" means permanent and total disability
as determined by the Administrator in accordance with the
standards set forth in Section 22(e)(3) of the Code.

          (i)  "Exchange Act" means the Securities Exchange Act
of 1934, as amended from time to time, and any successor statute.

          (j)  "Expiration Date" shall mean the last day of the
term of an Option established under Section 6(c).

          (k)  "Fair Market Value" means as of any given date
(a) the closing price of the Common Stock on the Nasdaq National
Market as reported in the Wall Street Journal; or (b) if the
Common Stock is no longer quoted on the Nasdaq National Market
but is listed on an established stock exchange or quoted on any
other established interdealer quotation system, the closing price
for the Common Stock on such exchange or system, as reported in
the Wall Street Journal.

          (l)  "Nonemployee Director" shall mean any person who
is a member of the Board but is not an employee of the Company or
any Affiliate of the Company and has not been an employee of the
Company or any Affiliate of the Company at any time during the
preceding twelve months.  Service as a director does not in
itself constitute employment for purposes of this definition.

          (m)  "Option" shall mean a stock option granted
pursuant to this Plan.  Each Option shall be a nonstatutory
option not intended to qualify as an incentive stock option
within the meaning of Section 422 of the Code.

          (n)  "Option Agreement" shall mean the written
agreement described in Section 6 evidencing the grant of an
Option to a Nonemployee Director and containing the terms,
conditions and restrictions pertaining to such Option.

          (o)  "Optionee" shall mean a Nonemployee Director who
holds an Option.

          (p)  "Plan" shall mean this Penederm Incorporated 1994
Nonemployee Directors Stock Option Plan, as it may be amended
from time to time.

          (q)  "Section" unless the context clearly indicates
otherwise, shall refer to a Section of this Plan.

          (r)  "Shares" shall mean the shares of Common Stock
subject to an Option granted under this Plan.

          (s)  "Tax Date" means the date defined in Section 7(c).

          (t)  "Termination" means, for purposes of the Plan,
with respect to an Optionee, that the Optionee has ceased to be,
for any reason, a director of the Company.

          (u)  "Window Period" means any 10-day period beginning
on the third business day following the date of release for
publication of the Company's quarterly or annual summary
statements of earnings or such other period as is specified in
Rule 16b-3(e) under the Exchange Act, as such rule may be amended
from time to time, or any successor to such rule.

     3.   Administration.

          (a)  Administrator.  The Plan shall be administered by
the Board or, upon delegation by the Board, by a committee
consisting of not less than two directors (in either case, the
"Administrator").  The Administrator shall have no authority,
discretion or power to select the Nonemployee Directors who will
receive Options hereunder or to set the number of shares to be
covered by each Option granted hereunder, the exercise price of
such Option, the timing of the grant of such Option or the period
within which such Option may be exercised.  In connection with
the administration of the Plan, the Administrator shall have the
powers possessed by the Board.  The Administrator may act only by
a majority of its members.  The Administrator may delegate
administrative duties to such employees of the Company as it
deems proper, so long as such delegation is not otherwise
prohibited by Rule 16b-3 under the Exchange Act.  The Board at
any time may terminate the authority delegated to any committee
of the Board pursuant to this Section 3(a) and revest in the
Board the administration of the Plan.

          (b)  Administrator Determinations Binding.  Subject to
the limitations set forth in Section 3(a), the Administrator may
adopt, alter and repeal administrative rules, guidelines and
practices governing the Plan as it from time to time shall deem
advisable, may interpret the terms and provisions of the Plan,
any Option and any Option Agreement and may otherwise supervise
the administration of the Plan.  All decisions made by the
Administrator under the Plan shall be binding on all persons,
including the Company and Optionees.  No member of the
Administrator shall be liable for any action that he or she has
in good faith taken or failed to take with respect to this Plan
or any Option.

     4.   Eligibility.

          Only Nonemployee Directors may receive Options under
this Plan.

     5.   Shares Subject to Plan.

          (a)  Aggregate Number.  Subject to Section 9, the total
number of shares of Common Stock reserved and available for
issuance pursuant to Options under this Plan shall be 350,000
shares.  Such shares may consist, in whole or in part, of
authorized and unissued shares or shares reacquired in private
transactions or open market purchases, but all shares issued
under the Plan regardless of source shall be counted against the
350,000 share limitation.  If any Option terminates or expires
without being exercised in full, the shares issuable under such
Option shall again be available for issuance in connection with
other Options.  If shares of Common Stock issued pursuant to an
Option are repurchased by the Company, such Common Stock shall
not again be available for issuance in connection with Options.
To the extent the number of shares of Common Stock issued
pursuant to an Option is reduced to satisfy withholding tax
obligations, the number of shares withheld to satisfy the
withholding tax obligations shall not be available for later
grant under the Plan.

          (b)  No Rights as a Shareholder.  An Optionee shall
have no rights as a shareholder with respect to any Shares
covered by his or her Option until the issuance (as evidenced by
the appropriate entry on the books of the Company or its duly
authorized transfer agent) of a stock certificate evidencing such
Shares.  Subject to Section 9, no adjustment shall be made for
dividends (ordinary or extraordinary, whether in cash, securities
or other property), distributions, or other rights for which the
record date is prior to the date the certificate is issued.

     6.   Grant of Options.

          (a)  Mandatory Initial Option Grants.  Subject to the
terms and conditions of this Plan, if any person who is not, and
has not been in the preceding twelve months, an officer or
employee of the Company and who has not previously been a member
of the Board is elected or appointed as a member of the Board,
then on the effective date of such appointment or election the
Company shall grant to such new Nonemployee Director an Option to
purchase at an exercise price equal to the Fair Market Value of
such Shares on the date of such option grant (i) 5,000 shares, if
such person was elected or appointed to the Board on or prior to
March 4, 1996, or (ii) 7,500 shares if such person was elected or
appointed to the Board after March 4, 1996, or (iii) 10,000
shares if such person was elected or appointed to the Board on or
after June 16, 1997.

          (b)  Mandatory Annual Option Grants.  Subject to the
terms and conditions of this Plan, (i) on the date of the first
meeting of the Board immediately following the annual meeting of
shareholders of the Company (even if held on the same day as the
meeting of shareholders) commencing with the annual meeting of
shareholders held in 1994 and ending on March 4, 1996, the
Company shall grant to each such Nonemployee Director then in
office (other than a Nonemployee director who received a Grant
under Section 6(a) in the previous six months) an Option to
purchase 5,000 Shares at an exercise price equal to the Fair
Market Value of such Shares on the date of such option grant,
(ii) on the date of the first meeting of the Board immediately
following the annual meeting of stockholders of the Company (even
if held on the same day as the meeting of shareholders)
commencing with the annual meeting of shareholders held in 1996
and ending prior to the annual meeting of shareholders held in
1997, the Company shall grant to each such Nonemployee Director
then in office (other than a Nonemployee Director who received a
Grant under Section 6(a) on or after the record date for such
annual meeting) an Option to purchase at an exercise price equal
to the Fair Market Value of such shares on the date of such
option grant:  (A) 7,500 shares unless clause (B) below applies,
or (B) 12,500 shares if such Grant is being made at the 1996
annual meeting of shareholders and the Nonemployee Director did
not receive a grant under Section 6(a) or Section 6(b) since the
record date of the 1995 annual meeting of shareholders and (iii)
on the date of the first meeting of the Board immediately
following the annual meeting of shareholders of the Company (even
if held on the same day as the meeting of shareholders)
commencing with the annual meeting of shareholders held in 1997,
the Company shall grant to each such Nonemployee Director then in
office (other than a Nonemployee Director who received a Grant
under Section 6(a) on or after the record date for such annual
meeting) an option to purchase at an exercise price equal to the
Fair Market Value of such shares on the date of such option
grant:  (x) 10,000 shares unless clause (y) below applies, or (y)
15,000 shares if such Nonemployee Director is the Chairman of the
Board of the Company.

          (c)  Terms; Vesting.  Subject to the other provisions
of this Plan, each Option granted pursuant to this Plan shall be
for a term of ten years.  Each Option granted under Section 6(a)
and Section 6(b) shall become exercisable with respect to 1/365th
of the number of Shares covered by such Option for each day which
elapses after the date of grant, so that such Option shall be
fully exercisable on the first anniversary of the date such
Option was granted.

          (d)  Limitation on Other Grants.  The Administrator
shall have no discretion to grant Options under this Plan other
than as set forth in Sections 6(a) and 6(b).

          (e)  Option Agreement.  As soon as practicable after
the grant of an Option, the Optionee and the Company shall enter
into a written Option Agreement which specifies the date of
grant, the number of Shares, the option price, and the other
terms and conditions applicable to the Option.

          (f)  Assignment or Transfer.

               (i)  All or any portion of any Option may be
transferred by an Optionee to (i) the spouse, children or
grandchildren of the Optionee ("Immediate Family Members"), (ii)
a partnership in which such Immediate Family Members are the only
partners, or (iii) a trust or trusts for the exclusive benefit of
such Immediate Family Members, provided that (x) there may be no
consideration for such transfer, (y) the agreement pursuant to
which such Options are transferred must be in a form consistent
with this Plan, and must expressly provide for transferability in
a manner consistent with this Section 6(f), and (z) subsequent
transfers of transferred Options shall be prohibited except those
in accordance with Section 6(f)(ii).  Following transfer, any
such Options shall continue to be subject to the same terms and
conditions as were applicable immediately prior to transfer.  The
events of termination of Section 6(i) shall continue to be
applied with respect to the original Optionee, following which
the Options shall be exercisable by the transferee only to the
extent, and for the periods specified in Section 6(i).  Neither
the Company nor the Administrator shall have any obligation to
provide the transferee with notice of termination of an Optionee.

               (ii) Options shall be transferable only in
accordance with Section 6(f)(i) or by will or the laws of descent
and distribution.

          (g)  Limits on Exercise.  Subject to the other
provisions of this Plan, an Option shall be exercisable in such
amounts as are specified in the Option Agreement.

          (h)  Exercise Procedures.  To the extent the right to
purchase Shares has accrued, Options may be exercised, in whole
or in part, from time to time, by written notice from the
Optionee to the Company stating the number of Shares being
purchased, accompanied by payment of the exercise price for the
Shares, and other applicable amounts, as provided in Section 7.

          (i)  Termination.  In the event of Termination, Options
held at the date of Termination (and only to the extent then
exercisable) may be exercised in whole or in part at any time
within three months after the date of Termination (but in no
event after the Expiration Date), but not thereafter.
Notwithstanding the foregoing, if Termination is due to
retirement or to death or Disability, Options held at the date of
Termination (and only to the extent then exercisable) may be
exercised in whole or in part by the Optionee in the case of
retirement or Disability, by the participant's guardian or legal
representative or by the person to whom the Option is transferred
by will or the laws of descent and distribution, at any time
within two years from the date of Termination (but in no event
after the Expiration Date).

     7.   Payment and Taxes upon Exercise of Options.

          (a)  Purchase Price.  The purchase price of Shares
issued under this Plan shall be paid in full at the time an
Option is exercised.

          (b)  Delivery of Purchase Price.  Optionees may make
all or any portion of any payment due to the Company

               (i)  upon exercise of an Option, or

               (ii)  with respect to federal, state, local or
foreign tax payable in connection with the exercise of an Option,
by delivery of (x) cash, (y) check, or (z) a promissory note of
the Optionee or shares of Common Stock so long as, if applicable,
such property constitutes valid consideration for the Common
Stock under, and otherwise complies with, applicable law.  No
promissory note under the Plan shall have a term (including
extensions) of more than five years or shall be of a principal
amount exceeding 90% of the purchase price paid by the borrower.
Exercise of an Option may be made pursuant to a "cashless
exercise/sale" procedure pursuant to which funds to pay for
exercise of the Option are delivered to the Company by a broker
upon receipt of stock certificates from the Company, or pursuant
to which Optionees obtain margin loans from brokers to fund the
exercise of the Option.

          (c)  Tax Withholding.  The Optionee shall pay to the
Company in cash, promptly upon exercise of an Option or, if
later, the date that the amount of such obligations becomes
determinable (in either case, the "Tax Date"), all applicable
federal, state, local and foreign withholding taxes that the
Administrator, in its discretion, determines to result upon
exercise of an Option or from a transfer or other disposition of
shares of Common Stock acquired upon exercise of an Option or
otherwise related to an Option or shares of Common Stock acquired
in connection with an Option.

          A person who has exercised an Option may make an
election (i) to deliver to the Company a promissory note of the
Optionee on the terms set forth in Section 7(b), (ii) to tender
to the Company previously-owned shares of Common Stock held for
at least six months, or (iii) to have shares of Common Stock to
be obtained upon exercise of the Option withheld by the Company
on behalf of the Optionee, to pay the amount of tax that the
Administrator, in its discretion, determines to be required to be
withheld by the Company.  Any election pursuant to clause (iii)
above by a Optionee subject to Section 16 of the Exchange Act
shall be subject to the following limitations:  (1) such election
must be made at least six months before the Tax Date and shall be
irrevocable; or (2) such election must be made in (or made
earlier to take effect in) any Window Period (and the withholding
of the shares of Common Stock shall take place during such Window
Period) and shall be subject to approval by the Board, which
approval may be given any time after such election has been made,
and the Option must be held at least six months prior to the Tax
Date; provided, that, the election referenced in clause (2) above
may not be made unless (A) such election is consistent with Rule
16b-3(c)(2)(ii) under the Exchange Act, and (B) the Company has
been subject to the reporting requirements of Section 13(a) of
the Exchange Act for at least one year and has filed all reports
and statements required to be filed pursuant to that section for
that year.  The right to so withhold shares of Common Stock shall
relate separately to each Option.

     Any shares tendered to or withheld by the Company will be
valued at Fair Market Value on such date.  The value of the
shares of Common Stock tendered or withheld may not exceed the
required federal, state, local and foreign withholding tax
obligations as computed by the Company.

     8.   Use of Proceeds.

          Proceeds from the sale of Shares pursuant to this Plan
shall be used for general corporate purposes.

     9.   Adjustment of Shares.

          In the event of any merger, reorganization,
consolidation, recapitalization, stock dividend, stock split or
other change in corporate structure affecting the Common Stock,
appropriate adjustments shall be made by the Administrator in the
aggregate number and kind of shares of Stock reserved for
issuance under the Plan and in the number, kind and exercise
price of shares subject to outstanding Options; provided,
however, that the number of shares subject to any Option shall
always be a whole number.

     10.  Effect of Change in Control.

          In the event of a "Change in Control," any Options
outstanding as of the date such Change in Control is determined
to have occurred and not then exercisable and vested shall become
fully exercisable and vested.

     11.  No Right to Directorship.

          Neither this Plan nor any Option granted hereunder
shall confer upon any Optionee any right with respect to
continuation of the Optionee's membership on the Board or shall
interfere in any way with provisions in the Company's Articles of
Incorporation and By-Laws relating to the election, appointment,
terms of office, and removal of members of the Board.

     12.  Legal Requirements.

          The Company shall not be obligated to offer or sell any
Shares upon exercise of any Option unless the Shares are at that
time effectively registered or exempt from registration under the
federal securities laws and the offer and sale of the Shares are
otherwise in compliance with all applicable securities laws and
the regulations of any stock exchange on which the Company's
securities may then be listed.  The Company shall have no
obligation to register the securities covered by this Plan under
the federal securities laws or take any other steps as may be
necessary to enable the securities covered by this Plan to be
offered and sold under federal or other securities laws.  Upon
exercising all or any portion of an Option, an Optionee may be
required to furnish representations or undertakings deemed
appropriate by the Company to enable the offer and sale of the
Shares or subsequent transfers of any interest in the Shares to
comply with applicable securities laws.  Certificates evidencing
Shares acquired upon exercise of Options shall bear any legend
required by, or useful for purposes of compliance with,
applicable securities laws, this Plan or the Option Agreements.

     13.  Duration and Amendments.

          (a)  Duration.  This Plan shall become effective upon
adoption by the Board provided, however, that no Option shall be
exercisable unless and until written consent of the shareholders
of the Company, or approval of shareholders of the Company voting
at a validly called shareholders' meeting, is obtained within 12
months after adoption by the Board. If such shareholder approval
is not obtained within such time, Options granted hereunder shall
terminate and be of no force and effect from and after expiration
of such 12-month period.

          (b)  Amendment and Termination.  The Board may amend,
alter or discontinue the Plan or any Option, but no amendment,
alteration or discontinuance shall be made which would impair the
rights of an Optionee under an outstanding Option without the
Optionee's consent.  In addition, the Board may not amend or
alter the Plan without the approval of shareholders of the
Company entitled to vote at a duly held shareholders' meeting or
by an action by written consent and, if at a meeting, a quorum of
the voting power of the Company is represented in person or by
proxy, where such amendment or alteration would, except as
expressly provided in the Plan, increase the total number of
shares reserved for issuance pursuant to Options under the Plan
or in such other circumstances as the Board deems appropriate to
comply with Rule 16b-3 under the Exchange Act or otherwise.
Notwithstanding any other provision of this Section 12(b), the
provisions of the Plan governing (A) who is granted Options,
(B) the number of Shares to be covered by each Option, (C) the
exercise price of each Option, (D) the timing of the grant of
each Option, or (E) the period within which each Option may be
exercised, shall not be amended more than once every six months,
other than to comport with changes in the Code or the rules
thereunder or the Employee Retirement Income Security Act of
1974, as amended, or the rules thereunder.

          (c)  Effect of Amendment or Termination.  No Shares
shall be issued or sold under this Plan after the termination
hereof, except upon exercise of an Option granted before
termination.  Termination or amendment of this Plan shall not
affect any Shares previously issued and sold or any Option
previously granted under this Plan.

     14.  Rule 16b-3.

          With respect to persons subject to Section 16 of the
Exchange Act, transactions under this Plan are intended to comply
with the applicable conditions of Rule 16b-3 under the Exchange
Act.  To the extent any provision of this Plan or action by the
Administrator fails to so comply, it shall be adjusted to comply
with Rule 16b-3, to the extent permitted by law and deemed
advisable by the Administrator.  It shall be the responsibility
of persons subject to Section 16 of the Exchange Act, not of the
Company or the Administrator, to comply with the requirements of
Section 16 of the Exchange Act; and neither the Company nor the
Administrator shall be liable if this Plan or any transaction
under this Plan fails to comply with the applicable conditions of
Rule 16b-3, or if any such person incurs any liability under
Section 16 of the Exchange Act.



As amended through April 23, 1998.



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