<PAGE>
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
SCHEDULE 13G
(Rule 13d-102)
INFORMATION TO BE INCLUDED IN STATEMENTS
FILED PURSUANT TO RULES 13d-1(b), (c) AND (d) AND
AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b)
(Amendment No. )(1)
SHIRE PHARMACEUTICALS GROUP plc
- --------------------------------------------------------------------------------
(Name of Issuer)
Ordinary Shares, nominal value 5p
- --------------------------------------------------------------------------------
(Title of Class of Securities)
82481R106*
- --------------------------------------------------------------------------------
(CUSIP Number)
December 31, 1998
- --------------------------------------------------------------------------------
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:
[ ] Rule 13d-1 (b)
[X] Rule 13d-1 (c)
[ ] Rule 13d-1 (d)
- ----------
(1) The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
(Continued on following page(s))
Page 1 of 22 Pages
- -----------
* The CUSIP number provided is assigned to the American Depository Shares
representing the Ordinary Shares of the Issuer. The positions reported herein by
the Reporting Persons are held in the form of Ordinary Shares and American
Depository Receipts.
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 82481R106 13G Page 2 of 22 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Ventures II, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 3,554,720
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
3,554,720
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
3,554,720
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
2.5%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 82481R106 13G Page 3 of 22 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Partners II, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 3,554,720
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
3,554,720
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
3,554,720
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
2.5%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 82481R106 13G Page 4 of 22 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Ventures III, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 5,508,032
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
5,508,032
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
5,508,032
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
3.9%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 82481R106 13G Page 5 of 22 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Partners III, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 5,508,032
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
5,508,032
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
5,508,032
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
3.9%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 82481R106 13G Page 6 of 22 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Ventures IV, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 1,617,528
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
1,617,528
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,617,528
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
1.15%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 82481R106 13G Page 7 of 22 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Partners IV, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 1,617,528
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
1,617,528
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,617,528
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
1.15%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 82481R106 13G Page 8 of 22 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Ventures V, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 1,564,530
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
1,564,530
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,564,530
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
1.1%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 82481R106 13G Page 9 of 22 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
HealthCare Partners V, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 1,564,530
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
1,564,530
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,564,530
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
1.1%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 82481R106 13G Page 10 of 22 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
James H. Cavanaugh, Ph.D.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 12,244,810
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
12,244,810
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
12,244,810
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
8.7%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 82481R106 13G Page 11of 22 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
Harold R. Werner
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 12,244,810
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
12,244,810
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
12,244,810
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
8.7%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 82481R106 13G Page 12 of 22 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
William Crouse
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 12,244,810
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
12,244,810
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
12,244,810
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
8.7%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 82481R106 13G Page 13 of 22 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
John W. Littlechild
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 12,244,810
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
12,244,810
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
12,244,810
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
8.7%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 82481R106 13G Page 14of 22 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON
Mark Leschly
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
5 SOLE VOTING POWER
----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 8,690,090
OWNED BY
EACH ----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH
----------------------------------------------------
8 SHARED DISPOSITIVE POWER
8,690,090
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
8,690,090
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
6.2%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
Page 15 of 22
Item 1.
(a) Name of Issuer:
Shire Pharmaceuticals Group plc
(b) Address of Issuer's Principal Executive Offices:
East Anton
Andover, Hampshire
SP10 5RG England
Item 2.
(a) Name of Person Filing:
HealthCare Ventures II, L.P. ("HCV II"), HealthCare Partners II, L.P.
("HCP II"), HealthCare Ventures III, L.P. ("HCV III"), HealthCare
Partners III, L.P. ("HCP III"), HealthCare Ventures IV, L.P. ("HCV
IV"), HealthCare Partners IV, L.P. ("HCP IV"), HealthCare Ventures V,
L.P. ("HCV V"), HealthCare Partners V, L.P. ("HCP V"), Dr. Cavanaugh
and Messrs. Werner, Littlechild, Crouse and Leschly. See attached
Exhibit A which is a copy of their agreement in writing to file this
statement on behalf of each of them.(1)
(b) Address of Principal Business Office or, if none, Residence:
The business address for HCV II, HCP II, HCV III, HCP III, HCV IV, HCP
IV, HCV V, HCP V, Dr. Cavanaugh and Messrs. Werner and Crouse is 44
Nassau Street, Princeton, New Jersey 08542. The business address for
Messrs. Littlechild and Leschly is One Kendall Square, Building 300,
Cambridge, Massachusetts 02139.
(c) Citizenship:
HCV II, HCP II, HCV III, HCP III, HCV IV, HCP IV, HCV V and HCP V, are
limited partnerships organized under the laws of the State of Delaware.
Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly are
each United States citizens.
- --------
(1) Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse are general
partners of HCP II, which is the general partner of HCV II, the record holder of
3,554,720 shares of Issuer's securities reported hereto. Dr. Cavanaugh and
Messrs. Werner, Littlechild, Crouse and Leschly are general partners of each of
HCP III, HCP IV and HCP V, which are the general partner of HCV III, HCV IV and
HCV V respectively, the record holder of 5,508,032, 1,617,528 and 1,564,530
shares of Issuer's securities, respectively, reported hereto.
<PAGE>
Page 16 of 22
(d) Title of Class of Securities:
Ordinary Shares, nominal value 5p ("Shares").
(e) CUSIP Number:
82481R106 (American Depository Shares)
Item 3. If this statement is filed pursuant to Rule 13d-1(b), or
13d-2(b) or (c), check whether the person filing is a:
Inapplicable.
If this statement is filed pursuant to Rule 13d-1(c), check this
Box. [ ]
Item 4. Ownership.
(a) Amount Beneficially Owned:
As of December 31, 1998: HCV II and HCP II beneficially owned 3,554,720
Ordinary Shares of Issuer; HCV III and HCP III beneficially owned
5,508,032 Ordinary Shares of Issuer; HCV IV and HCP IV beneficially
owned 1,617,528 Ordinary Shares of Issuer; HCV V and HCP V beneficially
owned 1,564,530 Shares of Issuer, consisting of 1,534,530 Ordinary
Shares and 10,000 American Depository Shares(2); Dr. Cavanaugh, Messrs.
Littlechild, Werner and Crouse each beneficially owned 12,244,810
Ordinary Shares of Issuer consisting of 12,214,810 Ordinary Shares and
10,000 American Depository Shares; and Mr. Leschly beneficially owned
8,690,090 Ordinary Shares of Issuer consisting of 8,660,090 Ordinary
Shares and 10,000 American Depository Shares.
(b) Percent of Class:
As of December 31, 1998: the 3,554,720 Ordinary Shares of Issuer
beneficially owned by HCV II and HCP II constitute 2.5% of Issuer's
Shares outstanding; the 5,508,032 Ordinary Shares of Issuer
beneficially owned by HCV III and HCP III constitute 3.9% of Issuer's
Shares outstanding; the 1,617,528 Ordinary Shares of Issuer
beneficially owned by HCV IV and HCP IV constitute 1.15% of Issuer's
Shares outstanding; the 1,564,530 Ordinary Shares of Issuer
beneficially owned by HCV V and HCP V constitute 1.1% of Issuer's
Shares outstanding; the 12,244,810 Ordinary Shares of Issuer
beneficially owned by each of Dr. Cavanaugh and Messrs. Littlechild,
Crouse, and Werner constitute 8.7% of Issuer's Shares outstanding; and
the 8,690,090 Ordinary Shares of Issuer beneficially owned by Mr.
Leschly constitute 6.2% of Issuer's Shares outstanding.
- --------
(2) Each American Depository Share represents three Ordinary Shares.
<PAGE>
Page 17 of 22
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote:
Inapplicable
(ii) shared power to vote or to direct the vote:
HCV II, HCP II, Dr. Cavanaugh and Messrs. Werner, Littlechild and
Crouse share the power to vote or direct the vote of those shares
owned by HCV II.
HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner, Littlechild,
Crouse and Leschly share the power to vote or direct the vote of
those shares owned by HCV III.
HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner, Littlechild,
Crouse and Leschly share the power to vote or direct the vote of
those shares owned by HCV IV.
HCV V, HCP V, Dr. Cavanaugh and Messrs. Werner, Littlechild,
Crouse and Leschly share the power to vote or direct the vote of
those shares owned by HCV V.
(iii) sole power to dispose or to direct the disposition of:
Inapplicable
(iv) shared power to dispose of or to direct the disposition of:
HCV II, HCP II, Dr. Cavanaugh and Messrs. Werner, Littlechild and
Crouse share the power to dispose of or direct the disposition of
those Shares owned by HCV II.
HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner, Littlechild,
Crouse and Leschly share the power to dispose of or direct the
disposition of those Shares owned by HCV III.
HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner, Littlechild,
Crouse and Leschly share the power to dispose of or direct the
disposition of those Shares owned by HCV IV.
HCV V, HCP V, Dr. Cavanaugh and Messrs. Werner, Littlechild,
Crouse and Leschly share the power to dispose of or direct the
disposition of those Shares owned by HCV V.
<PAGE>
Page 18 of 22
Item 5. Ownership of Five Percent or less of a Class:
Inapplicable.
Item 6. Ownership of More than Five Percent on Behalf of Another Person:
Inapplicable.
Item 7. Identification and Classification of the Subsidiary Which Acquired the
Security Being Reported on by the Parent Holding Company:
Inapplicable.
Item 8. Identification and Classification of Members of the Group:
Inapplicable.
Item 9. Notice of Dissolution of Group:
Inapplicable.
Item 10. Certification:
By signing below I certify that, to the best of my knowledge and
belief, the securities referred to below were not acquired and
were not held for purpose of or with the effect of changing or
influencing the control of the issuer of the securities and were
not acquired and are not held in connection with or as a
participant in any transaction having that purpose or effect.
<PAGE>
Page 19 of 22
SIGNATURES
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.
Dated: February 12, 1999 HealthCare Ventures II, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners II, L.P.,
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Partners II, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Ventures III, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners III, L.P.,
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Partners III, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Ventures IV, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners IV, L.P.,
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Partners IV, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
<PAGE>
Page 20 of 2
Dated: February 12, 1999 HealthCare Ventures V, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners V, L.P.,
By: /s/ Jeffrey Steinberg
-------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Partners V, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
-------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 By: *
Princeton, New Jersey -------------------------------
James H. Cavanaugh, Ph.D.
Dated: February 12, 1999 By: *
Princeton, New Jersey -------------------------------
Harold R. Werner
Dated: February 12, 1999 By: *
Cambridge, Massachusetts -------------------------------
John W. Littlechild
Dated: February 12, 1999 By: *
Princeton, New Jersey -------------------------------
William Crouse
Dated: February 12, 1999 By: *
Cambridge, Massachusetts -------------------------------
Mark Leschly
--------------------------
*Signed by Jeffrey Steinberg as Attorney-in-Fact pursuant to the Power of
Attorney filed previously and incorporated herein by reference.
<PAGE>
Page 21 of 22
EXHIBIT A
AGREEMENT
JOINT FILING OF SCHEDULE 13G
The undersigned hereby agree to jointly prepare and file with regulatory
authorities a Schedule 13G and any future amendments thereto reporting each of
the undersigned's ownership of securities of Shire Pharmaceuticals Group plc and
hereby affirm that such Schedule 13G is being filed on behalf of each of the
undersigned.
Dated: February 12, 1999 HealthCare Ventures II, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners II, L.P.,
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Partners II, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Ventures III, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners III, L.P.,
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Partners III, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Ventures IV, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners IV, L.P.,
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Partners IV, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
<PAGE>
Page 22 of 22
Dated: February 12, 1999 HealthCare Ventures V, L.P.,
Princeton, New Jersey by its General Partner, HealthCare
Partners V, L.P.,
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 HealthCare Partners V, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
--------------------------------
Jeffrey Steinberg
Administrative Partner
Dated: February 12, 1999 By: *
Princeton, New Jersey --------------------------------
James H. Cavanaugh, Ph.D.
Dated: February 12, 1999 By: *
Princeton, New Jersey --------------------------------
Harold R. Werner
Dated: February 12, 1999 By: *
Cambridge, Massachusetts --------------------------------
John W. Littlechild
Dated: February 12, 1999 By: *
Princeton, New Jersey --------------------------------
William Crouse
Dated: February 12, 1999 By: *
Cambridge, Massachusetts --------------------------------
Mark Leschly
- -------------------
*Signed by Jeffrey Steinberg as Attorney-in-Fact
