<PAGE>
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
SCHEDULE 13G
(Rule 13d-102)
INFORMATION TO BE INCLUDED IN STATEMENTS FILED
PURSUANT TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS
THERETO FILED PURSUANT TO RULE 13d-2(b)
(Amendment No. 1 )(1)
GENZYME CORPORATION
--------------------
(Name of Issuer)
Genzyme Molecular Oncology Division Common Stock
------------------------------------------------------------------
(Title of Class of Securities)
372917500
--------------------------------------------------------------------
(CUSIP Number)
December 31, 1999
----------------------------------------------------------------------
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:
|_| Rule 13d-1 (b)
|X| Rule 13d-1 (c)
|_| Rule 13d-1 (d)
- ----------
(1) The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
(Continued on following page(s))
Page 1 of 23 Pages
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 2 of 23 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Ventures II, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
NUMBER OF 5 SOLE VOTING POWER
SHARES ______________________________________________
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY
EACH 372,052
REPORTING ___________________________________________________
PERSON WITH 7 SOLE DISPOSITIVE POWER
___________________________________________________
8 SHARED DISPOSITIVE POWER
372,050
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
372,052
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
2.8%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 3 of 23 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Partners II, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
NUMBER OF 5 SOLE VOTING POWER
SHARES
BENEFICIALLY ---------------------------------------------------
OWNED BY 6 SHARED VOTING POWER
EACH
REPORTING 372,052
PERSON WITH ---------------------------------------------------
7 SOLE DISPOSITIVE POWER
---------------------------------------------------
8 SHARED DISPOSITIVE POWER
372,050
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
372,052
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
2.8%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 4 of 23 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Ventures III, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
NUMBER OF 5 SOLE VOTING POWER
SHARES
BENEFICIALLY ---------------------------------------------------
OWNED BY 6 SHARED VOTING POWER
EACH
REPORTING 42,485
PERSON WITH ---------------------------------------------------
7 SOLE DISPOSITIVE POWER
---------------------------------------------------
8 SHARED DISPOSITIVE POWER
42,485
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
42,485
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
.32%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 5 of 23 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Partners III, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
NUMBER OF 5 SOLE VOTING POWER
SHARES
BENEFICIALLY ---------------------------------------------------
OWNED BY 6 SHARED VOTING POWER
EACH
REPORTING 42,485
PERSON WITH ---------------------------------------------------
7 SOLE DISPOSITIVE POWER
---------------------------------------------------
8 SHARED DISPOSITIVE POWER
42,485
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
42,485
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
.32%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 6 of 23 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Ventures IV, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
NUMBER OF 5 SOLE VOTING POWER
SHARES
BENEFICIALLY ---------------------------------------------------
OWNED BY 6 SHARED VOTING POWER
EACH
REPORTING 12,477
PERSON WITH ---------------------------------------------------
7 SOLE DISPOSITIVE POWER
---------------------------------------------------
8 SHARED DISPOSITIVE POWER
12,477
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
12,477
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
.09%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 7 of 23 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
HealthCare Partners IV, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- --------------------------------------------------------------------------------
NUMBER OF 5 SOLE VOTING POWER
SHARES
BENEFICIALLY ---------------------------------------------------
OWNED BY 6 SHARED VOTING POWER
EACH
REPORTING 12,477
PERSON WITH ---------------------------------------------------
7 SOLE DISPOSITIVE POWER
---------------------------------------------------
8 SHARED DISPOSITIVE POWER
12,477
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
12,477
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
.09%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 8 of 23 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
James H. Cavanaugh, Ph.D.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
NUMBER OF 5 SOLE VOTING POWER
SHARES
BENEFICIALLY ---------------------------------------------------
OWNED BY 6 SHARED VOTING POWER
EACH
REPORTING 427,014
PERSON WITH ---------------------------------------------------
7 SOLE DISPOSITIVE POWER
---------------------------------------------------
8 SHARED DISPOSITIVE POWER
427,014
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
427,014
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
3.2%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 9 of 23 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Harold R. Werner
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
NUMBER OF 5 SOLE VOTING POWER
SHARES
BENEFICIALLY ---------------------------------------------------
OWNED BY 6 SHARED VOTING POWER
EACH
REPORTING 427,014
PERSON WITH ---------------------------------------------------
7 SOLE DISPOSITIVE POWER
---------------------------------------------------
8 SHARED DISPOSITIVE POWER
427,014
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
427,014
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
3.2%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 10 of 23 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
William Crouse
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
NUMBER OF 5 SOLE VOTING POWER
SHARES
BENEFICIALLY ---------------------------------------------------
OWNED BY 6 SHARED VOTING POWER
EACH
REPORTING 427,014
PERSON WITH ---------------------------------------------------
7 SOLE DISPOSITIVE POWER
---------------------------------------------------
8 SHARED DISPOSITIVE POWER
427,014
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
427,014
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
3.2%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
- ------------------------------- -----------------------------
CUSIP NO. 372917500 13G Page 11 of 23 Pages
---------------
- ------------------------------- -----------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
John W. Littlechild
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [ ]
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- --------------------------------------------------------------------------------
NUMBER OF 5 SOLE VOTING POWER
SHARES
BENEFICIALLY ---------------------------------------------------
OWNED BY 6 SHARED VOTING POWER
EACH
REPORTING 427,014
PERSON WITH ---------------------------------------------------
7 SOLE DISPOSITIVE POWER
---------------------------------------------------
8 SHARED DISPOSITIVE POWER
427,014
- --------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
427,014
- --------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
SHARES*
[ ]
- --------------------------------------------------------------------------------
11 PERCENTAGE CLASS REPRESENTED BY AMOUNT IN ROW 9
3.2%
- --------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
- --------------------------------------------------------------------------------
* SEE INSTRUCTION BEFORE FILLING OUT!
<PAGE>
Page 12 of 23 Pages
Item 1.
(a) Name of Issuer:
Genzyme Corporation
(b) Address of Issuer's Principal Executive Offices:
Genzyme Corporation
One Kendall Square
Cambridge, MA 02139
Item 2.
(a) Name of Person Filing:(1)
HealthCare Ventures II, L.P. ("HCV II"), HealthCare Partners II,
L.P. ("HCP II"), HealthCare Ventures III, L.P. ("HCV III"),
HealthCare Partners III, L.P. ("HCP III"), HealthCare Ventures IV,
L.P. ("HCV IV"), HealthCare Partners IV, L.P. ("HCP IV"), Dr.
Cavanaugh and Messrs. Werner, Littlechild and Crouse. See attached
Exhibit A which is a copy of their agreement in writing to file this
statement on behalf of each of them.(2)
(b) Address of Principal Business Office or, if none, Residence:
The business address for HCV II, HCP II, HCV III, HCP III, HCV IV,
HCP IV and Dr. Cavanaugh and Messrs. Werner and Crouse is 44 Nassau
Street, Princeton, New Jersey 08542. The business address for Mr.
Littlechild is One Kendall Square, Building 300, Cambridge,
Massachusetts 02139.
(c) Citizenship:
HCV II, HCP II, HCV III, HCP III, HCV IV and HCP IV are limited
partnerships organized under the laws of the State of Delaware. Dr.
Cavanaugh and Messrs. Werner, Littlechild and Crouse are each United
States citizens.
- --------
(1) Mark Leschly withdrew as a general partner of HCP III and HCP IV, effective
July 1, 1999.
(2) Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse are general
partners of HCP II, HCP III and HCP IV, the general partner of each of HCV
II, HCV III and HCV IV, respectively, the record holder of Issuer's
securities.
<PAGE>
Page 13 of 23 Pages
(d) Title of Class of Securities:
Genzyme Molecular Oncology Division Common Stock ("Shares").
(e) CUSIP Number:
372917500
Item 3. If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b),
check whether the person filing is a:
Inapplicable
If this statement is filed pursuant to Rule 13d-1(c), check this
box.|X|
Item 4. Ownership.
(a) Amount Beneficially Owned:
As of December 31, 1999: HCV II and HCP II beneficially owned
372,052 Shares of Issuer's Common Stock; HCV III and HCP III
beneficially owned 42,485 Shares of Issuer's Common Stock; HCV IV
and HCP IV beneficially owned 12,477 Shares of Issuer's Common
Stock; Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse
beneficially owned 427,014 Shares of Issuer's Common Stock.
(b) Percent of Class:
As of December 31, 1999: the 372,052 Shares beneficially owned by
HCV II and HCP II constitute 2.8% of Issuer's Shares outstanding;
the 42,485 Shares beneficially owned by HCV III and HCP III
constitute .32% of the Issuer's Shares outstanding; the 12,477
Shares beneficially owned by HCV IV and HCP IV constitute .09% of
Issuer's Shares outstanding; the 427,014 Shares beneficially owned
by Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse
constitute 3.2% of Issuer's Shares outstanding.
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote:
Inapplicable
(ii) shared power to vote or to direct the vote: HCV II, HCP II,
Dr. Cavanaugh and Messrs. Werner, Littlechild, and Crouse
share the power to vote or direct the vote of those Shares
owned by HCV II.
<PAGE>
Page 14 of 23 Pages
HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner,
Littlechild and Crouse share the power to vote or direct the
vote of those Shares owned by HCV III.
HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner, Littlechild
and Crouse share the power to vote or direct the vote of those
Shares owned by HCV IV.
(iii) sole power to dispose or to direct the disposition of:
Inapplicable
(iv) shared power to dispose of or to direct the disposition of:
HCV II, HCP II, Dr. Cavanaugh and Messrs. Werner, Littlechild
and Crouse share the power to dispose of or direct the
disposition of those Shares owned by HCV II.
HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner,
Littlechild and Crouse share the power to dispose of or direct
the disposition of those Shares owned by HCV III.
HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner, Littlechild
and Crouse share the power to dispose of or direct the
disposition of those Shares owned by HCV IV.
Item 5. Ownership of Five Percent or less of a Class:
The Reporting Persons have ceased to be the beneficial owners of
more than five percent of a class of securities. [X]
Item 6. Ownership of More than Five Percent on Behalf of Another Person:
Inapplicable.
Item 7. Identification and Classification of the Subsidiary Which Acquired
the Security Being Reported on by the Parent Holding Company:
Inapplicable.
Item 8. Identification and Classification of Members of the Group:
Inapplicable.
Item 9. Notice of Dissolution of Group:
Inapplicable.
Item 10. Certification:
<PAGE>
Page 15 of 23 Pages
By signing below I certify that, to the best of my knowledge
and belief, the securities referred to below were not acquired
and were not held for purpose of or with the effect of
changing or influencing the control of the issuer of the
securities and were not acquired and are not held in
connection with or as a participant in any transaction having
that purpose or effect.
<PAGE>
Page 16 of 23 Pages
SIGNATURES
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.
<TABLE>
<CAPTION>
<S> <C>
Dated: February 11, 2000 HealthCare Ventures II, L.P.,
Princeton, New Jersey by its General Partner, HealthCare Partners II, L.P.
By: /s/ Jeffrey Steinberg
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Partners II, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Ventures III, L.P.,
Princeton, New Jersey by its General Partner, HealthCare Partners III, L.P.
By: /s/ Jeffrey Steinberg
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Partners III, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Ventures IV, L.P.,
Princeton, New Jersey by its General Partner, HealthCare Partners IV, L.P.
By: /s/ Jeffrey Steinberg
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Partners IV, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
-----------------------------------
Administrative Partner
Dated: February 11, 2000 By: *
Princeton, New Jersey -----------------------------------
James H. Cavanaugh, Ph.D.
Dated: February 11, 2000 By: *
Princeton, New Jersey -----------------------------------
Harold R. Werner
</TABLE>
<PAGE>
Page 17 of 23 Pages
<TABLE>
<CAPTION>
<S> <C>
Dated: February 11, 2000 By: *
Cambridge, Massachusetts -----------------------------------
John W. Littlechild
Dated: February 11, 2000 By: *
Princeton, New Jersey -----------------------------------
William Crouse
</TABLE>
- ----------------
* Signed by Jeffrey Steinberg as Attorney-in-Fact
<PAGE>
Page 18 of 23 Pages
EXHIBIT A
AGREEMENT
JOINT FILING OF SCHEDULE 13G
The undersigned hereby agree to jointly prepare and file with
regulatory authorities a Schedule 13G and any future amendments thereto
reporting each of the undersigned's ownership of securities of Genzyme
Corporation and hereby affirm that such Schedule 13G is being filed on behalf of
each of the undersigned.
<TABLE>
<CAPTION>
<S> <C>
Dated: February 11, 2000 HealthCare Ventures II, L.P.,
Princeton, New Jersey by its General Partner, HealthCare Partners II, L.P.
By: /s/ Jeffrey Steinberg
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Partners II, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Ventures III, L.P.,
Princeton, New Jersey by its General Partner, HealthCare Partners III,
L.P.
By: /s/ Jeffrey Steinberg
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Partners III, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Ventures IV, L.P.,
Princeton, New Jersey by its General Partner, HealthCare Partners IV,
L.P.
By: /s/ Jeffrey Steinberg
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Partners IV, L.P.
Princeton, New Jersey
By: /s/ Jeffrey Steinberg
-----------------------------------
Administrative Partner
</TABLE>
<PAGE>
<TABLE>
<CAPTION>
Page 19 of 23 Pages
<S> <C>
Dated: February 11, 2000 By: *
Princeton, New Jersey -----------------------------------
James H. Cavanaugh, Ph.D.
Dated: February 11, 2000
Princeton, New Jersey By: *
-----------------------------------
Dated: February 11, 2000 Harold R. Werner
Cambridge, Massachusetts
By: *
Dated: February 11, 2000 -----------------------------------
Princeton, New Jersey John W. Littlechild
By: *
-----------------------------------
William Crouse
</TABLE>
- ----------
* Signed by Jeffrey Steinberg as Attorney-in-Fact
<PAGE>
Page 20 of 23 Pages
SIGNATURES
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.
<TABLE>
<CAPTION>
<S> <C>
Dated: February 11, 2000 HealthCare Ventures II, L.P.,
Princeton, New Jersey by its General Partner, HealthCare Partners II, L.P.
By:
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Partners II, L.P.
Princeton, New Jersey
By:
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Ventures III, L.P.,
Princeton, New Jersey by its General Partner, HealthCare Partners III, L.P.
By:
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Partners III, L.P.
Princeton, New Jersey
By:
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Ventures IV, L.P.,
Princeton, New Jersey by its General Partner, HealthCare Partners IV, L.P.
By:
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Partners IV, L.P.
Princeton, New Jersey
By:
-----------------------------------
Administrative Partner
</TABLE>
<PAGE>
Page 21 of 23 Pages
<TABLE>
<CAPTION>
<S> <C>
Dated: February 11, 2000 By:
Princeton, New Jersey -----------------------------------
James H. Cavanaugh, Ph.D.
Dated: February 11, 2000 By:
Princeton, New Jersey -----------------------------------
Harold R. Werner
Dated: February 11, 2000 By:
Cambridge, Massachusetts -----------------------------------
John W. Littlechild
Dated: February 11, 2000 By:
Princeton, New Jersey -----------------------------------
William Crouse
</TABLE>
<PAGE>
Page 22 of 23 Pages
EXHIBIT A
AGREEMENT
JOINT FILING OF SCHEDULE 13G
The undersigned hereby agree to jointly prepare and file with
regulatory authorities a Schedule 13G and any future amendments thereto
reporting each of the undersigned's ownership of securities of Genzyme
Corporation and hereby affirm that such Schedule 13G is being filed on behalf of
each of the undersigned.
<TABLE>
<CAPTION>
<S> <C>
Dated: February 11, 2000 HealthCare Ventures II, L.P.,
Princeton, New Jersey by its General Partner, HealthCare Partners II, L.P.
By:
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Partners II, L.P.
Princeton, New Jersey
By:
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Ventures III, L.P.,
Princeton, New Jersey by its General Partner, HealthCare Partners III, L.P.
By:
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Partners III, L.P.
Princeton, New Jersey
By:
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Ventures IV, L.P.,
Princeton, New Jersey by its General Partner, HealthCare Partners IV, L.P.
By:
-----------------------------------
Administrative Partner
Dated: February 11, 2000 HealthCare Partners IV, L.P.
Princeton, New Jersey
By:
-----------------------------------
Administrative Partner
</TABLE>
<PAGE>
Page 23 of 23 Pages
<TABLE>
<CAPTION>
<S> <C>
Dated: February 11, 2000 By:
Princeton, New Jersey -----------------------------------
James H. Cavanaugh, Ph.D.
Dated: February 11, 2000 By: -----------------------------------
Princeton, New Jersey Harold R. Werner
Dated: February 11, 2000 By: -----------------------------------
Cambridge, Massachusetts John W. Littlechild
Dated: February 11, 2000 By: -----------------------------------
Princeton, New Jersey William Crouse
</TABLE>
