BIOSOURCE INTERNATIONAL INC
DEF 14A, 1999-04-30
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 14A
                                 (Rule 14a-101)

                    INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION
                Proxy Statement Pursuant to Section 14(a) of the
               Securities Exchange Act of 1934 (Amendment No.   )

Filed by the Registrant [X]
Filed by a Party other than the Registrant [_]

Check the appropriate box:

[_]  Preliminary Proxy Statement             [_]  Confidential, For Use of the
[X]  Definitive Proxy Statement                   Commission Only (as permitted
[_]  Definitive Additional Materials              by Rule 14a-6(e)(2))
[_]  Soliciting Material Pursuant to
     Rule 14a-11(c) or Rule 14a-12

                         BIOSOURCE INTERNATIONAL, INC.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)


- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[X]  No fee required.
[_]  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.


________________________________________________________________________________
1)   Title of each class of securities to which transaction applies:


________________________________________________________________________________
2)   Aggregate number of securities to which transaction applies:


________________________________________________________________________________
3)   Per unit price or other underlying value of transaction  computed  pursuant
     to Exchange  Act Rule 0-11 (set forth the amount on which the filing fee is
     calculated and state how it was determined):


________________________________________________________________________________
4)   Proposed maximum aggregate value of transaction:


________________________________________________________________________________
5)   Total fee paid:

     [_]  Fee paid previously with preliminary materials:


________________________________________________________________________________
     [_]  Check box if any part of the fee is offset as provided by Exchange Act
          Rule  0-11(a)(2)  and identify the filing for which the offsetting fee
          was paid  previously.  Identify  the previous  filing by  registration
          statement number, or the form or schedule and the date of its filing.


________________________________________________________________________________
          1)   Amount previously paid:


________________________________________________________________________________
          2)   Form, Schedule or Registration Statement No.:


________________________________________________________________________________
          3)   Filing Party:


________________________________________________________________________________
          4)   Date Filed:


<PAGE>


                          BIOSOURCE INTERNATIONAL, INC.

                                   -----------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                            TO BE HELD JULY 16, 1998

                                   -----------


TO OUR STOCKHOLDERS:

     Notice is hereby given that the 1999 Annual Meeting of Stockholders of
BioSource International, Inc. (the "Company") will be held at the Spanish Hills
Country Club, 999 Crestview Ave., Camarillo, California 93010, on July 16, 1999
at 9:00 a.m., Pacific Standard time. The Annual Meeting is being held for the
following purposes:

     1.   To elect five directors to hold office for one year and until their
          respective successors have been elected. The persons nominated by the
          Board of Directors of the Company James H. Chamberlain, Leonard M.
          Hendrickson, John R. Overturf, Jr., David J. Moffa, Ph.D. and Robert
          D. Weist, are described in the accompanying Proxy Statement;

     2.   To ratify the appointment of KPMG, LLP, as the Company's independent
          public accountants for the year ending December 31, 1999; and

     3.   To transact such other business as may properly come before the Annual
          Meeting or any adjournments or postponements thereof.

     Only stockholders of record of the Common Stock of the Company at the close
of business on May 17, 1998 are entitled to notice of and to vote at the Annual
Meeting and at any adjournments or postponements thereof.

     All stockholders of record are cordially invited to attend the Annual
Meeting in person. However, to ensure your representation at the Annual Meeting,
you are urged to mark, sign and return the enclosed Proxy as promptly as
possible in the postage prepaid envelope enclosed for that purpose. Any
stockholder of record attending the Annual Meeting may vote in person, even
though he or she has returned a Proxy.


                                           BY ORDER OF THE BOARD OF DIRECTORS



                                           /S/ JAMES H. CHAMBERLAIN
                                           ------------------------------------
                                           James H. Chamberlain
                                           CHAIRMAN OF THE BOARD,
                                           PRESIDENT AND CHIEF EXECUTIVE OFFICER


Camarillo, California
May 28, 1998



IN ORDER TO ENSURE YOUR REPRESENTATION AT THE MEETING, PLEASE COMPLETE, DATE,
SIGN AND RETURN THE ACCOMPANYING PROXY IN THE ENCLOSED ENVELOPE AS PROMPTLY AS
POSSIBLE. IF YOU RECEIVE MORE THAN ONE PROXY CARD BECAUSE YOU OWN SHARES
REGISTERED IN DIFFERENT NAMES OR AT DIFFERENT ADDRESS, EACH CARD SHOULD BE
COMPLETED AND RETURNED.


                                       Page 3
<PAGE>


                          BIOSOURCE INTERNATIONAL, INC.
                                 820 FLYNN ROAD
                           CAMARILLO, CALIFORNIA 93012
                                 (805) 987-0086

                                ----------------

                                 PROXY STATEMENT

                         ANNUAL MEETING OF STOCKHOLDERS
                            TO BE HELD JULY 16, 1999

                                  INTRODUCTION

     This Proxy Statement is furnished in connection with the solicitation of
proxies by the Board of Directors of BioSource International, Inc., a Delaware
corporation (the "Company"), for use at the 1999 Annual Meeting of Stockholders
(the "Annual Meeting") to be held at Spanish Hills Country Club, 999 Crestview
Ave., Camarillo, California 93010, on July 16, 1999 at 9:00 a.m., Pacific
Standard time, and at any adjournments or postponements thereof, for the
purposes set forth herein and in the attached Notice of Annual Meeting of
Stockholders. Accompanying this Proxy Statement is the Board of Directors' Proxy
for the Annual Meeting, which you may use to indicate your vote on the proposals
described in this Proxy Statement.

     All Proxies which are properly completed, signed and returned to the
Company prior to the Annual Meeting, and which have not been revoked, will
unless otherwise directed by the stockholder be voted in accordance with the
recommendations of the Board of Directors set forth in this Proxy Statement. A
stockholder of record may revoke his or her Proxy at any time before it is voted
either by filing with the Secretary of the Company, at its principal executive
offices, a written notice of revocation or a duly executed proxy bearing a later
date, or by attending the Annual Meeting and expressing a desire to vote his or
her shares in person.

     The close of business on May 17, 1998 has been fixed as the record date for
the determination of stockholders entitled to notice of and to vote at the
Annual Meeting or at any adjournments or postponements of the Annual Meeting. At
the record date, 7,179,100 shares of Common Stock, par value $.001 per share,
were outstanding. The Common Stock is the only outstanding class of securities
of the Company entitled to vote at the Annual Meeting.

     It is anticipated that this Proxy Statement and the accompanying Proxy will
be mailed to stockholders on or about May 28, 1999.

                                VOTING PROCEDURES

     A stockholder is entitled to cast one vote for each share held of record on
the record date on all matters to be considered at the Annual Meeting. The five
nominees for election as directors at the Annual Meeting who receive the highest
number of affirmative votes will be elected. Abstentions and broker non-votes
will be included in the number of shares present at the Annual Meeting for the
purpose of determining the presence of a quorum. Abstentions will be counted
toward the tabulation of votes cast on proposals submitted to stockholders and
will have the same effect as negative votes, while broker non-votes will not be
counted as votes cast for or against such matters.



<PAGE>


                              ELECTION OF DIRECTORS

     In accordance with the Bylaws of the Company, the Board of Directors has
fixed the number of directors at five. At each annual meeting of stockholders,
five directors are elected, each for a one-year term. Five directors will be
elected at the Annual Meeting.

     Unless otherwise instructed, the Proxy holders will vote the Proxies
received by them for the nominees named below. If any nominee is unable or
unwilling to serve as a director at the time of the Annual Meeting or any
postponements or adjournments, the Proxies will be voted for such other
nominee(s) as shall be designated by the current Board of Directors to fill any
vacancy. The Company has no reason to believe that any nominee will be unable or
unwilling to serve if elected as a director.

     The Board of Directors proposes the election of the following nominees as
directors:

                              James H. Chamberlain
                             Leonard M. Hendrickson
                              John R. Overturf, Jr.
                              David J. Moffa, Ph.D.
                                 Robert D. Weist

If elected, each nominee is expected to serve until the 2000 Annual Meeting of
Stockholders. The five nominees for election as directors at the Annual Meeting
who receive the highest number of affirmative votes will be elected.

THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE "FOR" THE ELECTION OF THE
NOMINEES LISTED ABOVE.


                                     Page 2
<PAGE>


INFORMATION WITH RESPECT TO NOMINEES, CONTINUING DIRECTORS AND EXECUTIVE
OFFICERS

     The following table sets forth certain information with respect to the
nominees, continuing directors and executive officers of the Company as of June
3, 1999.

       NAME                           AGE     POSITION
       ----                           ---     --------

       James H. Chamberlain            51    Chairman of the Board,
                                             President, Chief Executive Officer,
                                             Director and Director Nominee

       Leonard M. Hendrickson (1)      51    Director and Director Nominee

       John R. Overturf, Jr. (2)       38    Director and Director Nominee

       David J. Moffa, Ph.D. (1)       56    Director and Director Nominee

       Robert D. Weist (2)             59    Director and Director Nominee

       Larry A. May                    49    Chief Financial Officer,
                                             Executive Vice President - Finance

       Gus Davis                       51    Chief Operating Officer,
                                             Executive Vice President Sales and
                                             Marketing

       Dick Buford                     51    Secretary, Vice President Human 
                                             Resources

- ----------------------
(1)   Member of the Compensation Committee.
(2)   Member of the Audit Committee.
- ----------------------

     Brief statements setting forth the principal occupation and employment
during the past five years, the year in which first elected as director and
other information concerning each nominee and the executive officers appear
below.

     JAMES H. CHAMBERLAIN has served as Director, President and Chief Executive
Officer of the Company and its predecessor, BioSource Industries, Inc., since it
was founded in October 1989, and was elected as its Chairman of the Board in
November 1993. Previously, Mr. Chamberlain was Manager for Business Development
for Amgen, Inc., where he started and managed the Amgen Biologicals Division.
Mr. Chamberlain has held various executive positions with Browning Ferris
Industries and Amersham Corporation, a biomedical company, and was a research
biochemist for Wm. H. Rorer Pharmaceutical, a major pharmaceutical company. He
received his Bachelor of Arts degree from West Virginia University, and studied
biochemistry at the University of Pittsburgh.

     LEONARD M. HENDRICKSON has been a Director of the Company since October
1993. Mr. Hendrickson is the President of Isotope Products Laboratories, a
privately held company, a position he has held since February 1992. From
February 1990 to January 1992, Mr. Hendrickson served as the principal
consultant for Microchemics, a marketing and business development consulting
firm which he founded. Prior to that time, Mr. Hendrickson served as the
Director of Marketing for Scicor, a diagnostics laboratory in Indianapolis, and
held various executive positions with Amersham Corporation. Mr. Hendrickson has
also held positions with Marion Laboratories, a pharmaceutical company, and
Standard Oil Company. Mr. Hendrickson holds a Bachelor of 


                                     Page 3
<PAGE>

Science degree from the University of Pennsylvania and a Masters in Business
Administration from American University in Washington D.C.

     DAVID J. MOFFA, PH.D., has been a Director of the Company since April 1995.
Dr. Moffa serves: as the Regional Director and as special projects director for
Lab Corporation of America, Inc. (Fairmont, WV), positions he has held since
1982 and 1984, respectively; as Director of Medical Arts Lab/RBL, a position he
has held since 1985; and as Director of Lab Corporation of America, Inc.
(Altoona, PA), a position he has held since 1990. Dr. Moffa also serves as an
advisor and consultant to various diagnostic, scientific and health care
facilities, and is an owner and developer of GM Realty and Moffa Properties.
Prior to serving in his current positions, Dr. Moffa has served as a Director
and General Manager of BioMedical Reference and Roche BioMedical Labs, as
President, Chief Executive Officer and a Director of BioPreps Laboratories,
Inc., as Assistant Professor of Medical Biochemistry and Director of Dental
Biochemistry Programs at the West Virginia University School of Medicine, as NIH
Post Doctoral Fellow and Instructor in Medical Biochemistry as well as a
Graduate Research Assistant at the West Virginia University School of Medicine.
Dr. Moffa also serves on a number of committees and boards of directors of
various privately held companies and governmental offices. Dr. Moffa has
completed a post doctoral fellowship in Clinical Biochemistry at the West
Virginia University National Institutes of Health, holds a Ph.D in Medical
Biochemistry from the West Virginia University School of Medicine, a Masters of
Science degree in Biochemistry from West Virginia University and a Bachelor of
Arts degree in Pre-Medicine from West Virginia University.

     JOHN R. OVERTURF, JR. has been a Director of the Company since September
1993. Mr. Overturf serves: as the President of R.O.I., Inc., a private
investment company, a position he has held since July 1993; and as President of
the Combined Penny Stock Fund, Inc., a closed-end stock market fund, a position
he has held since September 1996. From September 1993 until September 1996, Mr.
Overturf served as Vice President of The Rockies Fund, Inc., a closed-end stock
market fund. From June 1984 until February 1992, Mr. Overturf served as Vice
President of Colorado National Bank. Mr. Overturf holds a Bachelor of Science
degree in Finance from the University of Northern Colorado.

     ROBERT D. WIEST has been a director of the Company since April 1996. Mr.
Wiest has been President of Weist Associates (a management consulting firm)
since April 1992. From January 1986 through April 1992, Mr. Weist was a
consultant to and Senior Vice President, Administration, General Counsel and
Secretary of Amgen, Inc., having served as Vice President, General Counsel and
Secretary from March 1982 through January 1986. Mr. Weist holds a Juris Doctor
degree from New York University and a Masters in Business Administration from
the University of Chicago.

     LARRY A. MAY became Executive Vice President - Finance and Chief Financial
Officer of the Company on June 1, 1998. Prior to joining BioSource, Mr. May
served in various capacities at Amgen, the world's largest biotechnology
company, from 1983 to May 31, 1998. From 1997 to May 1998, Mr. May served as
Treasurer of Amgen, and from 1988 to 1997, served as its Corporate
Controller/Chief Accounting Officer, and from 1983 to 1988, Mr. May served as
Corporate Controller of Amgen. Mr. May has also served as Vice President of
Finance-West Coast Operators for IDC Services, a company providing payroll and
accounting services to major advertising agencies, motion picture and television
production companies (1978-1983), was manager of accounting for Valley
Industries (1974-1978) and was a staff auditor and CPA for Arthur Anderson &
Company (1971-1974). Mr. May holds a BS degree in Business Administration and
Accounting from the University of Missouri.

     GUS DAVIS became Executive Vice President - Sales and Marketing and Chief
Operating Officer of the Company in June 1995. From February 1994 until June
1995, Mr. Davis served as Vice President of Sales and Marketing of the Company.
Prior to that time, since February 1993, Mr. Davis was employed as Vice
President of Sales and Marketing at Genosis BioTechnology, a company engaged in
the manufacture of oligonucleotides. From January 1983 to January 1993, Mr.
Davis was employed as the Midwestern Area Manager for Pharmacia BioTechnology, a
company involved in the sale of reagents and capital equipment used to purify
samples. Mr. Davis received his Bachelor of Science and Masters degree in
Biology and Chemistry from Sam Houston State University.


                                     Page 4
<PAGE>


     RICHARD O. BUFORD became Corporate Secretary of the Company in December
1998, and continues to serve as Vice President of Human Resources, a position he
has held since February 1993. From 1989 to 1992, Mr. Buford served as Vice
President of Operations for The Office Mart, a California regional commercial
furniture and office supply distributor. From 1978 to 1989, Mr. Buford held
various operational and administrative management positions with
Schwabacher/Frey, an office supply distribution unit of Hanson Industries, most
recently as Director of Finance & Administration from 1984-1989. Mr. Buford
received a Bachelors of Arts and a Masters degree in English from the University
of California at Santa Barbara.


BOARD MEETINGS AND COMMITTEES

     The Board of Directors held six meetings during fiscal 1998. No director
attended less than 75% of all the meetings of the Board of Directors and those
committees on which he or she served in fiscal 1998.

     The Board of Directors maintains an Audit Committee and a Compensation
Committee. The Audit Committee currently consists of Messrs. Overturf and Weist.
The Audit Committee recommends the engagement of the Company's independent
public accountants, reviews the scope of the audit to be conducted by such
independent public accountants, and meets with the independent public
accountants and the Chief Financial Officer of the Company to review matters
relating to the Company's financial statements, the Company's accounting
principles and its system of internal accounting controls, and reports its
recommendations as to the approval of the financial statements of the Company to
the Board of Directors. One meeting of the Audit Committee was held during the
year ended December 31, 1998.

     The Compensation Committee currently consists of Messrs. Hendrickson and
Moffa. The Compensation Committee is responsible for considering and making
recommendations to the Board of Directors regarding executive compensation and
is responsible for administering the Company's stock option and executive
incentive compensation plans. One meeting of the Compensation Committee was held
during the year ended December 31, 1998.

COMPENSATION OF DIRECTORS

     Nonemployee directors of the Company currently are paid $1,000 for each
Board meeting attended, and $1,000 per year for serving on a Board Committee.
The Company pays all out-of-pocket fees of attendance. In addition, non-employee
directors have received an annual grant of 4,000 non-statutory stock options
under the Company's 1993 Stock Incentive Plan, exercisable at the fair market
value of the Company's Common Stock on the date of grant, and which fully vest
on the date of grant.


                                     Page 5
<PAGE>


                             EXECUTIVE COMPENSATION

SUMMARY COMPENSATION TABLE

     The following table sets forth, as to the Chief Executive Officer and as to
each of the other four most highly compensated officers whose compensation
exceeded $100,000 during the last fiscal year (the "Named Executive Officers"),
information concerning all compensation paid for services to the Company in all
capacities for each of the three years ended December 31 indicated below.

                           SUMMARY COMPENSATION TABLE

<TABLE>
<CAPTION>

                                                  ANNUAL COMPENSATION       LONG TERM COMPENSATION
                                                 ---------------------      -----------------------
                                        YEAR                                NUMBER OF
                                        ENDED                               SECURITIES
                                       DECEMBER                             UNDERLYING    ALL OTHER
NAME AND PRINCIPAL POSITION (1)           31,     SALARY         BONUS       OPTIONS    COMPENSATION
- -------------------------------        --------   -------     ---------      --------   -----------
<S>                                     <C>      <C>           <C>           <C>        <C>        
James H. Chamberlain .......            1998     $250,000      $ 25,000      $100,000   $ 18,084(2)
Chairman of the Board                   1997      154,000        42,500          --       13,608(3)
Chief Executive Officer and             1996      144,000       113,072       137,500      8,612(3)
President                               

Gus Davis ..................            1998     $150,000      $  8,000      $ 14,500   $  6,395(4)
Chief Operating Officer                 1997      110,000        12,500          --        4,579(5)
and Executive Vice President            1996       95,000        20,000          --        3,600(5)

Larry A. May ...............            1998     $ 87,500(7)        -0-      $100,000   $    508(6)
Chief Financial Officer
and Executive Vice President
</TABLE>

- ----------
(1)  For a description of employment agreements between certain executive
     officers and the Company, see "Employment Agreements with Executive
     Officers" below.
(2)  Consists of $11,616 for an auto lease paid by the Company, $4,740 for
     country club membership dues paid by the Company, and $1,728 for a group
     life insurance premium paid by the Company.
(3)  Consists of country club membership dues paid by the Company.
(4)  Consists of $4,955 for a car allowance paid by the Company and $1,440 for a
     group life insurance premium paid by the Company.
(5)  Consists of $3,600 for a car allowance paid by the Company, $979 for a
     group life insurance premium paid buy the Company.
(6)  Consists of a group life insurance premium paid by the Company. 
(7)  Joined Company 6/1/98.


OPTION GRANTS IN LAST FISCAL YEAR

     The following table sets forth certain information regarding the grant of
stock options made during the fiscal year ended December 31, 1998 to the Named
Executive Officers.


                                     Page 6
<PAGE>

<TABLE>
<CAPTION>
                        OPTION GRANTS IN LAST FISCAL YEAR

                                                                                        POTENTIAL
                                                                                        REALIZABLE
                                                                                         VALUE OF
                                                                                      ASSUMED ANNUAL
                            NUMBER OF     PERCENT OF                                  RATES OF STOCK
                            SECURITIES   TOTAL OPTIONS                                    PRICE
                            UNDERLYING    GRANTED TO     EXERCISE OF                   APPRECIATION
                             OPTIONS     EMPLOYEES IN     BASE PRICE    EXPIRATION   FOR OPTION TERM
NAME                        GRANTED(1)  FISCAL YEAR(2)    ($/SH.)(3)       DATE            (2)
- -------------------------   ---------    -----------     ----------    ----------    ---------------
                                                                                      5%($)   10%($)
                                                                                      -----   ------
<S>                          <C>             <C>             <C>         <C>   <C>    <C>      <C> 
James H. Chamberlain......   100,000         7.97%           2.5625      12/17/08     4.17     6.65

Gus Davis.................    25,000         1.99%           2.5625      12/17/08     4.17     6.65

Larry May.................    40,000                         6.625       06/01/08     0.79    17.18
                              60,000                         2.5625      12/17/08     4.17     6.65
</TABLE>
- ----------
(1)  Options granted in 1998 vest over various periods. The options were granted
     for a term of 10 years.
(2)  Options covering an aggregate of 1,254,950 shares were granted to employees
     of the Company and its subsidiary during the year ended December 31, 1998.
(3)  The exercise price and the tax withholding obligations related to exercise
     may be paid by delivery of already owned shares, subject to certain
     conditions.


                                     Page 7
<PAGE>


STOCK OPTIONS HELD AT FISCAL YEAR END

     The following table sets forth, for those Named Executive Officers who held
stock options at fiscal year end, certain information regarding the number of
shares of Common Stock underlying stock options held at fiscal year end and the
value of options held at fiscal year end based upon the last reported sales
price of the Common Stock on Nasdaq market on December 31, 1998 ($2.9375 per
share). No stock options were exercised by any Named Executive Officer during
fiscal 1998.

<TABLE>
<CAPTION>
                    AGGREGATED FISCAL YEAR-END OPTION VALUES

                                  NUMBER OF SECURITIES      
                                  UNDERLYING UNEXERCISED          VALUE OF UNEXERCISED
                                       OPTIONS AT                IN-THE-MONEY OPTIONS AT
NAME                              DECEMBER 31, 1998              DECEMBER 31, 1998 (1)
- ----                            --------------------------   -----------------------------
                                EXERCISABLE  UNEXERCISABLE   EXERCISABLE     UNEXERCISABLE
                                -----------  -------------   -----------    ----------------
<S>                               <C>           <C>         <C>             <C>      
James H. Chamberlain...........   400,259       37,241      $ 240,625       $       -0-
Gus Davis......................    89,478          522         96,907               752
Larry May......................    60,000       40,000         22,800               -0-
Kevin Reagan...................     8,438       24,062            -0-             3,800
Jordan Fishman.................       -0-      100,000            -0-            13,000
</TABLE>


EMPLOYMENT AGREEMENTS WITH EXECUTIVE OFFICERS

     Effective as of January 2, 1998, James Chamberlain entered into an
employment agreement with the Company which superseded Mr. Chamberlain's
existing Employment Agreement dated January 2, 1996. The term of the Employment
Agreement is three years. Pursuant to the terms of the Employment Agreement, Mr.
Chamberlain is to be paid an annual salary of $250,000 for each year of the
Agreement, an annual bonus determined on the basis of the Company's existing
management incentive plan which is limited to $100,000 for each year of the
Agreement and is to receive certain additional benefits.

     In the event there is a "change of control" of the Company, Mr. Chamberlain
may terminate his employment agreement, in which case, the Company is obligated
to continue to pay Mr. Chamberlain his then-current base salary for a period of
12 months following the effective date of such termination. A "change of
control" includes (i) the acquisition by any person or entity of shares of
capital stock of the Company entitled to exercise 35% or more of the total
voting power of the Company, (ii) the execution by the Company of an agreement
to sell or otherwise transfer all or substantially all of its assets or the
execution by the Company of an agreement to merge, consolidate or reorganize
with any other corporation or entity, which results in less than 75% of the
total voting power represented by the capital stock or other equity interests of
the corporation or entity to which the Company's assets are sold or transferred
or surviving such merger, consolidation or reorganization being held by the
persons and entities who were holders of common stock of the Company on January
1, 1998, (iii) the issuance by the Company, otherwise than on a pro rata basis,
of additional shares of capital stock representing (after giving effect to such
issuance) more than 35% of the total voting power of the Company, or (iv) if the
persons who were the directors of the Company as of January 1, 1998 cease to
comprise a majority of the Board of Directors of the Company.

STOCK OPTION PLAN

     The Company adopted a Stock Option Plan (the "1993 Plan") in 1993. The
purpose of the 1993 Plan is to attract, retain and motivate certain key
employees of the Company by giving them incentives which are linked directly to
increases in the value of the Common Stock of the Company. Each officer,
director and employee and under certain circumstances, consultants of the
Company is eligible to be considered for the grant of awards under the 1993
Plan. The maximum number of shares of Common Stock that may be issued pursuant
to awards granted under the 1993 Plan is 2,000,000, subject to certain
adjustments to prevent dilution. Any shares of Common 


                                     Page 8
<PAGE>


Stock subject to an award which for any reason expires or terminates unexercised
are again available for issuance under the 1993 Plan.

     The 1993 Plan authorizes the Compensation Committee to enter into any type
of arrangement with an eligible employee that, by its terms, involves or might
involve the issuance of (1) shares of Common Stock, (2) an option, warrant,
convertible security, stock appreciation right or similar right with an exercise
or conversion privilege at a price related to the Common Stock, or (3) any other
security or benefit with a value derived from the value of the Common Stock. Any
stock option granted may be an incentive stock option within the meaning of
Section 422 of the Internal Revenue Code of 1986, as amended (the "Code") or a
nonqualified stock option. The 1993 Plan currently is administered by the
Compensation Committee of the Board of Directors of the Company. Subject to the
provisions of the 1993 Plan, the Compensation Committee will have full and final
authority to select the executives and other employees to whom awards will be
granted thereunder, to grant the awards and to determine the terms and
conditions of the awards and the number of shares to be issued pursuant thereto.

     As of December 31, 1998, the Board had granted options covering an
aggregate of 3,468,950 of Common Stock to certain directors, officers and
employees of the Company, of which options to purchase 2,117,646 were
outstanding.


             SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

     Section 16(a) of the Securities Exchange Act of 1934, requires the
Company's executive officers, directors, and persons who own more than ten
percent of a registered class of the Company's equity securities to file reports
of ownership and changes in ownership with the Securities and Exchange
Commission (the "SEC"). Executive officers, directors and greater-than-ten
percent stockholders are required by SEC regulations to furnish the Company with
all Section 16(a) forms they file. Based solely on its review of the copies of
the forms received by it and written representations from certain reporting
persons that they have complied with the relevant filing requirements, the
Company believes that, during the year ended December 31, 1998, all the
Company's executive officers, directors and greater-than-ten percent
stockholders complied with all Section 16(a) filing requirements, except that
James H. Chamberlain reported the disposition by gift of 2000 shares of Common
Stock to the University of West Virginia on a Form 5 filed prior to February 15,
1999 with respect to the transaction which occurred on December 10, 1998.


                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
                      WITH DIRECTORS AND EXECUTIVE OFFICERS


        The Company's Chairman of the Board, President, and Chief Executive
Officer, James H. Chamberlain, is indebted to the Company in the aggregate
principal amount of $434,000 as of May 31, 1998, which was the largest aggregate
amount of such indebtedness during fiscal 1997. The loans are represented by two
separate promissory notes, one in the principal amount of $350,000, bearing
interest 5.9% per annum, and one in the principal amount of $84,000, bearing
interest at 5.51% per annum. Each loan provides for interest only payments,
payable monthly, with all principal due upon demand.


                                     Page 9
<PAGE>


                                PERFORMANCE GRAPH

     The following graph sets forth the percentage change in cumulative total
shareholder return of the Company's Common Stock during the period from December
31, 1993 to December 31, 1998, compared with the cumulative returns of the
Nasdaq Stock Market (US Companies) Index and the Russell 2000 Index. The
Comparison assumes $100 was invested on December 31, 1993 in the Common Stock
and in each of the foregoing indices. The stock price performance on the
following graph is not necessarily indicative of future stock price performance.


                               [GRAPHICS OMITTED]

<TABLE>
<CAPTION>
                                                            CUMULATIVE TOTAL RETURN
                                                ------------------------------------------------
                                                12/93    12/94   12/95    12/96   12/97   12/98
<S>                                             <C>      <C>     <C>      <C>     <C>     <C>
BIOSOURCE INTERNATIONAL, INC.                   100      60      249      301     279     129
NASDAQ STOCK MARKET (U.S.)                      100      98      138      170     208     294
HAMBRECHT & QUIST BIOTECHNOLOGY                 100      95      162      149     151     230
</TABLE>


                                    Page 10
<PAGE>

                           RATIFICATION OF APPOINTMENT
                             OF INDEPENDENT AUDITORS

     The Audit Committee of the Board of Directors recommended and the Board has
selected, subject to ratification by a majority vote of the shareholders in
person or by proxy at the annual meeting, the firm of KPMG, LLP (the "Auditors")
to continue as the Company's independent public accountant for the current
fiscal year ending December 31, 1999. The Auditors have served as the principal
independent public accounting firm utilized by the Company during the years
ended December 31, 1994, 1995, 1996, 1997 and 1998. The Company anticipates that
a representative of the Auditors will attend the Annual Meeting for the purpose
of responding to appropriate questions. At the Annual Meeting, a representative
of the Auditors will be afforded an opportunity to make a statement if the
Auditors so desire.

     THE BOARD OF DIRECTORS UNANIMOUSLY APPROVED THE ADOPTION OF PROPOSAL NO. 2.
THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE FOR PROPOSAL NO. 2
RATIFYING THE APPOINTMENT OF KPMG, LLP AS THE COMPANY'S INDEPENDENT AUDITORS.


                                    Page 11
<PAGE>


                                OTHER INFORMATION

PRINCIPAL STOCKHOLDERS

     The following table sets forth as of April 30, 1999 certain information
relating to the ownership of the Common Stock by (i) each person known by the
Company to be the beneficial owner of more than five percent of the outstanding
shares of the Company's Common Stock, (ii) each of the Company's directors,
(iii) each of the Named Executive Officers, and (iv) all of the Company's
executive officers and directors as a group. Except as may be indicated in the
footnotes to the table and subject to applicable community property laws, each
such person has the sole voting and investment power with respect to the shares
owned. The address of each person listed is in care of the Company, 820 Flynn
Road, Camarillo, California 93012, unless otherwise set forth below such
person's name.

<TABLE>
<CAPTION>
                                                    NUMBER OF SHARES OF
                                                       COMMON STOCK           
           NAME AND ADDRESS                        BENEFICIALLY OWNED (1)       PERCENT (1)
           ----------------                        ---------------------        ------------
<S>                                                    <C>                       <C>   
James H. Chamberlain                                   825,856(2)                10.84%

Leonard M. Hendrickson                                  75,200(3)                 1.04%*

John R. Overturf, Jr.                                   63,000(4)                  .87%*

David J. Moffa, Ph.D.                                   61,900(5)                 1.5%*

Robert D. Weist                                         53,000(6)                  .7%*

Richard Buford                                          60,123(7)                  .83%

Directors and executive officers as a group (7       1,339,079(8)                16.55%
persons)
- ----------
</TABLE>

*  Less than one percent.

(1)   Under Rule 13d-3, certain shares may be deemed to be beneficially owned by
      more than one person (if, for example, persons share the power to vote or
      the power to dispose of the shares). In addition, shares are deemed to be
      beneficially owned by a person if the person has the right to acquire the
      shares (for example, upon exercise of an option) within 60 days of the
      date as of which the information is provided. In computing the percentage
      ownership of any person, the amount of shares outstanding is deemed to
      include the amount of shares beneficially owned by such person (and only
      such person) by reason of these acquisition rights. As a result, the
      percentage of outstanding shares of any person as shown in this table does
      not necessarily reflect the person's actual ownership or voting power with
      respect to the number of shares of Common Stock actually outstanding at
      April 15, 1999.
(2)   Includes (i) 437,500 shares of Common Stock reserved for issuance upon
      exercise of stock options which are currently exercisable; (ii) 385,156
      shares of Common Stock held in the Chamberlain Family Trust for which Mr.
      Chamberlain serves as trustee; and (iii) 3,200 shares of Common Stock held
      in Mr. Chamberlain's IRA Account;
(3)   Includes (i) 63,000 shares of Common Stock reserved for issuance upon
      exercise of stock options which are currently exercisable; (ii) 4,000
      shares of Common Stock held of record by two of Mr. Hendrickson's minor
      children; and (iii) 7,400 shares of Common Stock held in the Microchemics
      Simplified Employee Pension Plan.


                                     Page 12
<PAGE>


(4)   Includes 61,000 shares of Common Stock reserved for issuance upon exercise
      of stock options which are currently exercisable.
(5)   Includes (i) 55,500 shares of Common Stock reserved for issuance upon
      exercise of stock options which are currently exercisable; and (ii) 200
      shares of Common Stock held jointly with, or solely by, Dr. Moffa's
      spouse.
(6)   Includes 53,000 shares of Common Stock reserved for issuance upon exercise
      of stock options which are currently exercisable.
(7)   Includes (i) 53,500 shares of Common Stock reserved for issuance upon
      exercise of stock options which are currently exercisable, (ii) 631 shares
      of Common Stock held in Employee Stock Purchase Plan, (iii) 3,500 shares 
      of Common Stock held in Mr. Buford's IRA account, (iv) 1000 shares of 
      Common Stock held in Mr. Buford's Roth IRA account, (v) 2123 shares of
      Common Stock held in Mr. Buford's Family Trust account.
(8)   Includes 914,131 shares of Common Stock reserved for issuance upon
      exercise of stock options which are currently exercisable.


                                    Page 13
<PAGE>


                              STOCKHOLDER PROPOSALS

     Any stockholder of record who intends to present a proposal at the next
Annual Meeting of Stockholders for inclusion in the Company's Proxy Statement
and Proxy form relating to such Annual Meeting must submit such proposal to the
Company at its principal executive offices by January 3, 2000.


                             SOLICITATION OF PROXIES

     It is expected that the solicitation of proxies will be primarily by mail.
The cost of solicitation by management will be borne by the Company. The Company
will reimburse brokerage firms and other persons representing beneficial owners
of shares for their reasonable disbursements in forwarding solicitation material
to such beneficial owners. Proxies may also be solicited by certain of the
Company's directors and officers, without additional compensation, personally or
by mail, telephone, telegram or otherwise for the purpose of soliciting such
proxies.


                           ANNUAL REPORT ON FORM 10-K

     THE COMPANY'S ANNUAL REPORT ON FORM 10-K, WHICH HAS BEEN FILED WITH THE
SECURITIES AND EXCHANGE COMMISSION FOR THE YEAR ENDED DECEMBER 31, 1998, WILL BE
MADE AVAILABLE TO STOCKHOLDERS WITHOUT CHARGE UPON WRITTEN REQUEST TO Larry may,
CHIEF FINANCIAL OFFICER, BIOSOURCE INTERNATIONAL, INC., 820 FLYNN ROAD,
CAMARILLO, CALIFORNIA 93012

                       ON BEHALF OF THE BOARD OF DIRECTORS



                                           /S/ JAMES H. CHAMBERLAIN
                                           -------------------------------------
                                           James H. Chamberlain
                                           CHAIRMAN OF THE BOARD,
                                           PRESIDENT AND CHIEF FINANCIAL OFFICER






Camarillo, California
May 28, 1999



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