BIOSOURCE INTERNATIONAL INC
S-8, 2000-02-18
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     -----

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                                     -----

                          BIOSOURCE INTERNATIONAL INC.
             (Exact Name of Registrant as Specified in Its Charter)

                DELAWARE                                 77-0340829
      (State or Other Jurisdiction                   (I.R.S. Employer
    of Incorporation or Organization)               Identification No.)

         820 FLYNN ROAD, SUITE A                          93012
          CAMARILLO, CALIFORNIA                        (Zip Code)
         (Address of Principal
          Executive Offices)

                           NON-STATUTORY STOCK OPTIONS
                            1993 STOCK INCENTIVE PLAN
                            (Full Title of The Plan)

                              JAMES H. CHAMBERLAIN
                      CHIEF EXECUTIVE OFFICER AND PRESIDENT
                             820 FLYNN ROAD, SUITE A
                           CAMARILLO, CALIFORNIA 93012
                                 (805) 987-0086
 (Name, Address and Telephone Number, Including Area Code, of Agent For Service)

                          Copies of communications to:
                             SCOTT W. ALDERTON, ESQ.
                    TROOP STEUBER PASICH REDDICK & TOBEY, LLP
                       2029 CENTURY PARK EAST, 24TH FLOOR
                          LOS ANGELES, CALIFORNIA 90067
                                 (310) 728-3000

<TABLE>
                                                    CALCULATION OF REGISTRATION FEE
=================================================================================================================================
<CAPTION>
     Title Of Securities          Amount To Be           Proposed Maximum            Proposed Maximum            Amount Of
      To Be Registered             Registered           Offering Price Per          Aggregate Offering          Registration
                                                              Share                        Price                     Fee
- ---------------------------------------------------------------------------------------------------------------------------------
  <S>                           <C>                         <C>                        <C>                       <C>
        Common Stock,             50,000 shares             $ 2.6875                   $   134,375                   --
  par value $.001 per share

- ---------------------------------------------------------------------------------------------------------------------------------
        Common Stock,             50,000 shares             $ 2.0000                   $   100,000                   --
  par value $.001 per share

- ---------------------------------------------------------------------------------------------------------------------------------
        Common Stock,            100,000 shares             $ 1.5000                   $   150,000                   --
  par value $.001 per share

- ---------------------------------------------------------------------------------------------------------------------------------
        Common Stock,            137,500 shares             $ 5.2500                   $   721,875                   --
  par value $.001 per share

- ---------------------------------------------------------------------------------------------------------------------------------
        Common Stock,             30,000 shares             $ 1.6875                   $    50,625                   --
  par value $.001 per share

- ---------------------------------------------------------------------------------------------------------------------------------
        Common Stock,             10,000 shares             $ 6.4375                   $    64,375                   --
  par value $.001 per share

- ---------------------------------------------------------------------------------------------------------------------------------
        Common Stock,            100,000 shares             $ 2.8125                   $   281,250                   --
  par value $.001 per share

- ---------------------------------------------------------------------------------------------------------------------------------
        Common Stock,             25,000 shares             $12.8125                   $   320,313                   --
  par value $.001 per share

- ---------------------------------------------------------------------------------------------------------------------------------
        Common Stock,            500,000 shares             $19.09375(1)               $ 9,546,875(1)                --
  par value $.001 per share

- ---------------------------------------------------------------------------------------------------------------------------------
                    TOTALS:     1,002,500                         --                   $11,369,688               $ 3002
- ---------------------------------------------------------------------------------------------------------------------------------

<FN>
(1)     Estimated solely for purposes of calculating the registration fee pursuant to Rule 457(h)(1) under the Securities Act of
        1933, as amended, and based upon the exercise price of the option pursuant to which such shares may be acquired.
</FN>
</TABLE>


<PAGE>


                                     PART I*


                INFORMATION REQUIRED IN SECTION 10(A) PROSPECTUS


ITEM 1.  PLAN INFORMATION.

ITEM 2.  REGISTRANT INFORMATION AND EMPLOYEE PLAN ANNUAL INFORMATION.

     *    Information required by Part I to be contained in the Section 10(a)
          prospectus is omitted from the Registration Statement in accordance
          with Rule 428 under the Securities Act of 1933, as amended, and the
          Note to Part I of Form S-8.


                                     PART II

ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE.

     The following documents filed by the Registrant with the Commission are
incorporated herein by reference:

          (a) The Registrant's Annual Report on Forms 10-K and 10-K/A for the
     fiscal year ended December 31, 1998;

          (b) The Registrant's Current Report on Form 8-K, filed as of March 1,
     1999;

          (c) The Registrant's Quarterly Report on Form 10-Q for the quarter
     ended March 31, 1999;

          (d) The Registrant's Quarterly Report on Form 10-Q for the quarter
     ended June 30, 1999;

          (e) The Registrant's Quarterly Report on Form 10-Q for the quarter
     ended September 30, 1999;

          (f) The description of the Common Stock contained in the Registrant's
     Registration Statement on Form SB-2, as amended, filed by the Registrant on
     May 30, 1996 pursuant to Section 12 of the Exchange Act.

          (g) All documents subsequently filed by Registrant pursuant to
     Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934,
     prior to the filing of a post-effective amendment which indicates that all
     securities offered have been sold or which deregisters all securities then
     remaining unsold, shall be deemed to be incorporated by reference in this
     Registration Statement and to be part hereof from the date of filing of
     such documents.

ITEM 4.  DESCRIPTION OF SECURITIES.

     The securities to be offered are registered under Section 12 of the
Exchange Act of 1934.


                                     Page 2
<PAGE>


ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL.

          Not applicable.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.

     Section 145 of the Delaware General Corporation Law provides in relevant
part that a corporation may indemnify any person who was or is a party to or is
threatened to be made a party to any threatened, pending or completed action,
suit or proceeding, whether civil, criminal, administrative or investigative
(other than an action by or in the right of the corporation) by reason of the
fact that such person is or was a director, officer, employee or agent of the
corporation, partnership, joint venture, trust or other enterprise, against
expenses (including attorneys' fees), judgments, fines and amounts paid in
settlement actually and reasonably incurred by such person in connection with
such action, suit or proceeding if such person acted in good faith and in a
manner such person reasonably believed to be in or not opposed to the best
interests of the corporation, and with respect to any criminal action or
proceeding, had no reasonable cause to believe such person's conduct was
unlawful.

     In addition, Section 145 provides that a corporation may indemnify any
person who was or is a party or is threatened to be made a party to any
threatened, pending or completed action or suit by or in the right of the
corporation to procure a judgment in its favor by reason of the fact that such
person is or was a director, officer, employee or agent of the corporation, or
is or was serving at the request of the corporation as a director, officer,
employee or agent of another corporation, partnership, joint venture, trust or
other enterprise against expenses (including attorneys' fees) actually and
reasonably incurred by such person in connection with the defense or settlement
of such action or suit if such person acted in good faith and in a manner such
person reasonably believed to be in or not opposed to the best interests of the
corporation and except that no indemnification shall be made in respect of any
claim, issue or matter as to which such person shall have been adjudged to be
liable to the corporation unless and only to the extent that the Delaware Court
of Chancery or the court in which such action or suit was brought shall
determine upon application that, despite the adjudication of liability but in
view of all the circumstances of the case, such person is fairly and reasonably
entitled to indemnity for such expenses which the Delaware Court of Chancery or
such other court shall deem proper. Delaware law further provides that nothing
in the above-described provisions shall be deemed exclusive of any other rights
to indemnification or advancement of expenses to which any person may be
entitled under any bylaw, agreement, vote of stockholders or disinterested
directors or otherwise.

     Article VIII of the Registrant's Certificate of Incorporation provides for
the indemnification of directors to the fullest extent permissible under
Delaware law.

     Article V of the Registrant's Bylaws provides for the indemnification of
officers, directors and third parties acting on behalf of the Registrant if such
person acted in good faith and in a manner reasonably believed to be in and not
opposed to the best interest of the Registrant, and, with respect to any
criminal action or proceeding, the indemnified party had no reason to believe
his or her conduct was unlawful.

     The Registrant has entered into indemnification agreements with its
directors and executive officers, in addition to indemnification provided for in
the Registrant's Bylaws, and intends to enter into indemnification agreements
with any new directors and executive officers in the future.


                                     Page 3
<PAGE>


     In addition, the Registrant has purchased insurance pursuant to which its
directors and officers are insured against liability which they may incur in
their capacity as such.

     Insofar as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
has been advised that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Securities Act
and is, therefore, unenforceable.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED.

     Not applicable.

ITEM 8.  EXHIBITS.

          5.1  Opinion of Troop Steuber Pasich Reddick & Tobey, LLP.

          10.1 Stock Option Agreement, dated as of May 19, 1993, by and between
               Registrant and James H. Chamberlain.

          10.2 Stock Option Agreement, dated as of May 19, 1993, by and between
               Registrant and James H. Chamberlain.

          10.3 Stock Option Agreement, dated as of January 23, 1995, by and
               between Registrant and James H. Chamberlain.

          10.4 Stock Option Agreement, dated as of January 3, 1996, by and
               between Registrant and James H. Chamberlain.

          10.5 Stock Option Agreement, dated as of June 1, 1995, by and between
               Registrant and Gus Davis.

          10.6 Stock Option Agreement, dated as of April 5, 1996, by and between
               Registrant and Robert Weist.

          10.7 Option Certificate, dated as of December 9, 1998, by and between
               Registrant and David S. Fishman.

          10.8 Option Certificate, dated as of December 9, 1998, by and between
               Registrant and Jordan B. Fishman, Ph.D.

          10.9 Amendment to 1993 Stock Incentive Plan, dated as of December 17,
               1998.

          23.1 Consent of KPMG LLP, Independent Public Accountants.

          23.2 Consent of Troop Steuber Pasich Reddick & Tobey, LLP (included in
               Exhibit 5.1).


                                     Page 4
<PAGE>


          24.1 Power of Attorney (included on signature page).

ITEM 9.  UNDERTAKINGS.

          (a) The undersigned registrant hereby undertakes:

               (1) To file, during any period in which offers or sales are being
          made, a post-effective amendment to this registration statement to
          include any material information with respect to the plan of
          distribution not previously disclosed in the registration statement or
          any material change to such information in the registration statement;

               (2) That, for the purpose of determining any liability under the
          Securities Act, each such post-effective amendment shall be deemed to
          be a new registration statement relating to the securities offered
          therein, and the offering of such securities at that time shall be
          deemed to be the initial BONA FIDE offering thereof;

               (3) To remove from registration by means of a post-effective
          amendment any of the securities being registered which remain unsold
          at the termination of this offering; and

          (b) The undersigned registrant hereby undertakes that, for purposes of
     determining any liability under the Securities Act of 1933, each filing of
     the registrant's annual report pursuant to Section 13(a) or 15(d) of the
     Securities Exchange Act of 1934 (and, where applicable, each filing of an
     employee benefit plan's annual report pursuant to Section 15(d) of the
     Securities Exchange Act of 1934) that is incorporated by reference in the
     registration statement shall be deemed to be a new registration statement
     relating to the securities offered therein, and the offering of such
     securities at that time shall be deemed to be the initial BONA FIDE
     offering thereof.

     Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers or controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
has been advised that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Securities Act
of 1933 and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
Registrant of expenses incurred or paid by a director, officer or controlling
person of the Registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Securities
Act of 1933 and will be governed by the final adjudication of such issue.


                                     Page 5
<PAGE>


                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Los Angeles, State of California as of February 14,
2000.


                                       BIOSOURCE INTERNATIONAL INC.
                                       (Registrant)


                                        By:  /S/ JAMES H. CHAMBERLAIN
                                             -----------------------------------
                                             James H. Chamberlain
                                             Chief Executive Officer and
                                                  President

                                POWER OF ATTORNEY

     Each person whose signature appears below constitutes and appoints James H.
Chamberlain as his true and lawful attorney-in-fact and agent, with full power
of substitution, for him and in his name, place and stead, in any and all
capacities, to sign any or all amendments to this Registration Statement on Form
S-8, and to file the same, with all exhibits thereto and other documents in
connection therewith, with the Securities and Exchange Commission, granting unto
said attorney-in-fact and agent full power and authority to do and perform each
and every act and thing requisite and necessary to be done in and about the
foregoing, as fully to all intents and purposes as he might or could do in
person, and hereby ratifying and confirming all that said attorney-in-fact and
agent, or his substitute, may lawfully do or cause to be done by the virtue
hereof.

     Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.


<TABLE>
<CAPTION>

             SIGNATURE                              TITLE                              DATE
             ---------                              -----                              ----
  <S>                                     <C>                                   <C>

    /S/ JAMES H. CHAMBERLAIN              Chairman of the Board,                February 14, 2000
  ----------------------------            President and Chief
      James H. Chamberlain                Executive Officer


   /S/ LEONARD M. HENDRICKSON             Director                              February 14, 2000
  ----------------------------
     Leonard M. Hendrickson


      /S/ DAVID J. MOFFA                  Director                              February 14, 2000
  ----------------------------
      David J. Moffa, Ph.D


   /S/ JOHN R. OVERTURF, JR.              Director                              February 14, 2000
  ----------------------------
    John R. Overturf, Jr.


     /S/ ROBERT D. WEIST                  Director                              February 14, 2000
  ----------------------------
      Robert D. Weist
</TABLE>


                                     Page 6
<PAGE>


                                 EXHIBIT INDEX

  EXHIBIT NO.                          DESCRIPTION
  -----------                          -----------

     5.1  Opinion of Troop Steuber Pasich Reddick & Tobey, LLP.

     10.1 Stock Option Agreement, dated as of May 19, 1993, by and between
          Registrant and James H. Chamberlain.

     10.2 Stock Option Agreement, dated as of May 19, 1993, by and between
          Registrant and James H. Chamberlain.

     10.3 Stock Option Agreement, dated as of January 23, 1995, by and between
          Registrant and James H. Chamberlain.

     10.4 Stock Option Agreement, dated as of January 3, 1996, by and between
          Registrant and James H. Chamberlain.

     10.5 Stock Option Agreement, dated as of June 1, 1995, by and between
          Registrant and Gus Davis.

     10.6 Stock Option Agreement, dated as of April 5, 1996, by and between
          Registrant and Robert Weist.

     10.7 Option Certificate, dated as of December 9, 1998, by and between
          Registrant and David S. Fishman.

     10.8 Option Certificate, dated as of December 9, 1998, by and between
          Registrant and Jordan B. Fishman, Ph.D.

     10.9 Amendment to 1993 Stock Incentive Plan, dated as of December 17, 1998.

     23.1 Consent of KPMG LLP, Independent Public Accountants.

     23.2 Consent of Troop Steuber Pasich Reddick & Tobey, LLP (included in
          Exhibit 5.1).

     24.1 Power of Attorney (included on signature page).


                                     Page 7

Exhibit 5.1


                                  LETTERHEAD OF
                    TROOP STEUBER PASICH REDDICK & TOBEY, LLP


February 14, 2000

BioSource International Inc.
820 Flynn Road, Suite A
Camarillo, California 93012

Ladies/Gentlemen:

     At your request, we have examined the Registration Statement on Form S-8
(the "REGISTRATION STATEMENT") to which this letter is attached as Exhibit 5.1
filed by BioSource International Inc., a Delaware corporation (the "COMPANY"),
in order to register under the Securities Act of 1933, as amended (the "ACT"),
1,002,500 shares of Common Stock, $.001par value per share (the "SHARES"), of
the Company issuable pursuant to the Amendment to the 1993 BioSource
International, Inc. Stock Incentive Plan (the "AMENDMENT") and the following 8
documents (collectively, the "OPTION AGREEMENTS"): (i) an option granted to
James H. Chamberlain pursuant to a Stock Option Agreement, dated as of May 19,
1993, by and between the Company and James H. Chamberlain; (ii) an option
granted to James H. Chamberlain pursuant to a Stock Option Agreement, dated as
of May 19, 1993, by and between the Company and James H. Chamberlain; (iii) an
option granted to James H. Chamberlain pursuant to a Stock Option Agreement,
dated as of January 23, 1995, by and between the Company and James H.
Chamberlain; (iv) an option granted to James H. Chamberlain pursuant to a Stock
Option Agreement, dated as of January 3, 1996, by and between the Company and
James H. Chamberlain; (v) an option granted to Gus Davis pursuant to a Stock
Option Agreement, dated as of June 1, 1995, by and between the Company and Gus
Davis (vi) an option granted to Robert Weist pursuant to a Stock Option
Agreement, dated as of April 5, 1996, by and between the Company and Robert
Weist; (vii) an option granted to David S. Fishman pursuant to an Option
Certificate, dated as of December 9, 1998, by and between the Company and David
S. Fishman; and (viii) an option granted to Jordan B. Fishman pursuant to an
Option Certificate, dated as of December 9, 1998, by and between the Company and
Jordan B. Fishman .

     We are of the opinion that the Shares have been duly authorized and upon
issuance and sale in conformity with and pursuant to the Amendment and the
Option Agreements, the Shares will be validly issued, fully paid and
non-assessable.

     We consent to the use of this opinion as an Exhibit to the Registration
Statement and to use of our name in the Prospectus constituting a part thereof.

                                 Respectfully submitted,


                                  /S/ TROOP STEUBER PASICH REDDICK & TOBEY, LLP
                                  ---------------------------------------------
                                      TROOP STEUBER PASICH REDDICK & TOBEY, LLP


Exhibit 10.1


                             STOCK OPTION AGREEMENT
                          (NON-STATUTORY STOCK OPTION)

     This STOCK OPTION AGREEMENT (this "Option Agreement") is made and entered
into on the date set forth on the signature page hereof, by and between
BIOSOURCE INTERNATIONAL, INC. ( the "Company"), and James H. Chamberlain
("Optionee").

     The Board of Directors of the Company (the "Board") has authorized the
grant to Optionee of a non-statutory stock option to purchase shares of the
Company's Common Stock, par value $0.001 per share (the "Common Stock"), upon
the terms and subject to the conditions set forth in this Agreement.

     The Company and Optionee agree as follows:

     1. GRANT OF OPTION.

     The Company hereby grants to Optionee the right and option (the "Option"),
upon the terms and subject to the conditions set forth in this Agreement, to
purchase up to 50,000 shares of the Common Stock (the "Shares"), at an Option
Exercise Price (the "Exercise Price") of $2.6875 per share.

     2. TERM OF OPTION.

     The Option shall terminate and expire on the date (the "Option Expiration
Date") which is ten years from the date of this Option Agreement, unless sooner
terminated as provided herein.

     3. VESTING.

     The Option shall become immediately exercisable upon execution of this
Agreement.

     4. EXERCISE OF OPTION.

     There is no obligation to exercise the Option, in whole or in part. The
Option may be exercised, in whole or in part, only by delivery to the Company
of:

          (a) written notice of exercise in form and substance identical to
     Exhibit "A" attached to this Option Agreement stating the number of shares
     of Common Stock then being purchased (the "Purchased Shares"); and

          (b) payment of the Exercise Price of the Purchased Shares, either in
     cash, by check, or by transfer to the Company of issued and outstanding
     shares of Common Stock, or by any combination of the above methods of
     payment. If payment is made, in whole or in part, by transfer to the
     Company of issued and outstanding shares of Common Stock, the value of such
     shares shall be determined as follows: (i) if, at the time of payment, the
     Common Stock is traded on the National Market System or any national or
     regional stock exchange, the value of each share shall be the closing sale
     price of a share of Common Stock on the business day immediately preceding
     the payment or, if no sale was made on that date, on the most recent date
     when such a sale was made, as reported on the composite tape for securities
     transactions or similar source for reporting sales of the Common Stock;
     (ii) if, at the time of payment, quotations with respect to the Common
     Stock are made on the NASDAQ System, the value of each share


<PAGE>


     shall be the average of the closing bid and asked quotations of a share of
     Common Stock on the business day immediately preceding the payment or, if
     no quotations were made on that date, on the most recent date when such
     quotations were made; or (iii) if, at the time of payment, neither (i) nor
     (ii) above is applicable, the value of each share shall be the fair market
     value of each share, as determined by the Board or the Administrator.

     Following receipt of the notice and payment referred to above, the Company
shall issue and deliver to Optionee a stock certificate or stock certificates
evidencing the Purchased Shares; PROVIDED, HOWEVER, that the Company shall not
be obligated to issue a fraction or fractions of a share of its Common Stock,
and may pay to Optionee, in cash or by check, the fair market value of any
fraction or fractions of a share exercised by Optionee, which fair market value
shall be determined as set forth in the preceding paragraph.

     5. RESTRICTIONS ON PURCHASED SHARES.

     Optionee shall not sell, transfer (with or without consideration), assign,
pledge, hypothecate or otherwise dispose of (collectively, "Transfer") any of
the Purchased Shares unless and until ALL of the following have occurred:

          (a) The Purchased Shares are disposed of pursuant to and in conformity
     with an effective registration statement filed with the Securities and
     Exchange Commission (the "Commission") pursuant to the Securities Act of
     1933, as amended (the "Act"), or the proposed disposition will not result
     in a violation of the securities laws of any state of the United States;
     and

          (b) If requested by the Company, Optionee shall, prior to the transfer
     of such Purchased Shares, deliver to the Company a written opinion of
     counsel, satisfactory to the Company and its counsel, that the proposed
     disposition will comply with the requirements set forth in clause (a)
     above, in which case, the Company shall bear all reasonable costs of such
     counsel in preparing such opinion.

     Any attempted Transfer which is not in full compliance with this Paragraph
5 shall be null and void AB INITIO, and of no force or effect.


                                  EX-10-1 - 2
<PAGE>


     6. ADJUSTMENTS UPON RECAPITALIZATION.

          Subject to any required action by the stockholders of the Company:

          (a) If outstanding shares of the Common Stock shall be subdivided into
     a greater number of shares of the Common Stock, or a dividend in Shares of
     Common Stock or other securities of the Company convertible into or
     exchangeable for shares of the Common Stock (in which latter event the
     number of shares of Common Stock issuable upon the conversion or exchange
     of such securities shall be deemed to have been distributed) shall be paid
     in respect of the shares of Common Stock, the Exercise Price in effect
     immediately prior to such subdivision or at the record date of such
     dividend shall, simultaneously with the effectiveness of such subdivision
     or immediately after the record date of such dividend, be proportionately
     reduced, and conversely, if the outstanding shares of Common Stock shall be
     combined into a smaller number of shares of Common Stock, the Exercise
     Price in effect immediately prior to such combination shall, simultaneously
     with the effectiveness of such combination, be proportionately increased.

          (b) In the event the Company at any time, or from time to time, shall
     make or issue, or fix a record date for the determination of holders of
     shares of Common Stock entitled to receive, a dividend or other
     distribution payable in securities or the Company other than shares of
     Common Stock or securities convertible into or exchangeable for shares of
     Common Stock then and in each such event, provision shall be made so that
     the holder of the Option shall receive upon exercise thereof, in addition
     to the number of shares receivable thereupon, the amount of securities of
     the Company which he or she would have received had his or her Option been
     exercised on the date of such event and had thereafter, during the period
     from the date of such event to and including the date of exercise, retained
     such securities receivable by him or her as aforesaid during such period,
     giving application to all adjustments called for during such period under
     this Paragraph 6 with respect to the rights of the holder of the Option.

          (c) When any adjustment is required to be made in the Exercise Price,
     the number of Shares purchasable upon the exercise of the Option shall be
     adjusted to that number of Shares determined by (i) multiplying an amount
     equal to the number of Shares purchasable on the exercise of the Option
     immediately prior to such adjustment by the Exercise Price in effect
     immediately prior to such adjustment, and then (ii) dividing that product
     by the Exercise Price in effect immediately after such adjustment.

          (d) In case of any capital reorganization, any reclassification of the
     Common Stock (other than a change in par value or recapitalization
     described in Paragraph 6(a) or 6(b) of this Agreement), or the
     consolidation of the Company with, or a sale of substantially all of the
     assets of the Company to (which sale is followed by a liquidation or
     dissolution of the Company), or merger of the Company with, another person
     where, in each such case, the Company is the "surviving corporation," as
     defined in Paragraph 6(j) below, Optionee shall thereafter be entitled upon
     exercise of the Option to purchase the kind and number of shares of stock
     or other securities or property of the surviving corporation receivable
     upon such event by a holder of the number of shares of the Common Stock
     which the Option entitles Optionee to purchase from the Company any
     immediately prior to such event; and in any such case, appropriate
     adjustment shall be made in the application of the provisions set forth in
     this Agreement with respect to Optionee's rights and interests thereafter,
     to the end that the provisions set forth in this Agreement (including the
     specified changes and other adjustments to the Exercise Price) shall
     thereafter be applicable in relation to any shares or other property
     thereafter purchasable upon exercise of the Option.


                                  EX-10-1 - 3
<PAGE>


          (e) A consolidation of the Company with, or a sale of substantially
     all of the assets of the Company to (which sale is followed by a
     liquidation or dissolution of the Company), or the Merger of the Company
     with, any other person (other than a consolidation, sale or merger in which
     the Company is the "Surviving Corporation," as defined in Paragraph 6 (j)
     below) shall cause the Option to terminate on the Effective Date of such
     consolidation, sale or merger; PROVIDED, HOWEVER, that the Optionee shall
     have the right during a ten day period ending on the fifth day prior to
     such consolidation, sale or merger to exercise the Option, in whole or in
     part, without regard to the installment provision set forth in Paragraph 3
     of this Option Agreement; but any exercise of the Option which except for
     the provisions of this Paragraph 6(e) would not then be exercisable, shall
     be conditioned upon the actual occurrence of such consolidation, sale or
     merger, and if such consolidation, sale of merger is abandoned or otherwise
     does not occur, for any reason, the Optionee's exercise of the Option
     during such ten day period shall be null and void, and of no force and
     effect; PROVIDED, FURTHER, that if such consolidation, sale or merger is to
     be consummated, in whole or in part, by the tender of Common Stock to the
     Surviving Corporation, the Optionee hereby agrees to tender the Shares
     issued upon exercise of his or her Option to the Surviving Corporation, if
     so directed by the board of directors of the Company, and to vote such
     Shares for or against such consolidation, sale or merger, as directed by
     the board of directors of the Company. For purposes of this Paragraph 6(e)
     and subject to the previous sentence, any exercise of the Option by
     optionee pursuant to this Paragraph 6 shall be deemed to occur immediately
     prior to the consummation of such consolidation, sale or merger.

          (f) If the Company is dissolved or liquidated then the Option shall
     terminate on the effective date of such dissolution or liquidation;
     PROVIDED, HOWEVER, the Optionee shall have the right during a ten day
     period ending on the fifth day prior to such dissolution or liquidation to
     exercise his or her Option in whole or in part, without regard to any of
     the installment provisions set forth in Paragraph 3 of this Agreement; but
     the exercise of the Option which except for the provisions of this
     Paragraph 6(f) would not then be exercisable, shall be conditioned upon the
     actual occurrence of such dissolution or liquidation, and if such
     dissolution or liquidation were not to occur, the Optionee's exercise of
     the Option during such ten day period shall be null and void, and of no
     force and effect. For purposes of the this Paragraph 6(f) and subject to
     the previous sentence, any exercise of the Option by Optionee pursuant to
     this Paragraph 6(f) shall be deemed to occur immediately prior the
     consummation of such dissolution or liquidation.

          (g) To the extent that the foregoing adjustments relate to stock or
     securities of the Company, such adjustments shall be made by the
     Administrator, and its determination shall be final, binding and
     conclusive.

          (h) The provisions of this Paragraph 6 are intended to be exclusive,
     and Optionee shall have no other rights upon the occurrence of any of the
     events described in this Paragraph 6.

          (i) The grant of the Option shall not affect in any way the right or
     power of the Company to make adjustments, reclassifications,
     reorganizations or changes in its capital or business structure, or to
     merge, consolidate, dissolve or liquidate, or to sell or transfer all or
     any part of its business or assets.

          (j) The determination as to which party is the "surviving corporation"
     in a consolidation, sale or merger shall be made on the basis of the
     relative equity interests of the stockholders in the corporation existing
     after the consolidation, sale or merger, as follows: If following any
     consolidation, sale or merger the holders of outstanding voting securities
     of the Company prior to the consolidation, sale or merger own equity
     securities possessing more than 50% of the voting power of the


                                  EX-10-1 - 4
<PAGE>


     corporation existing after the consolidation, sale or merger, then for
     purposes of this Agreement, the Company shall be the surviving corporation.
     In all other cases, the Company shall not be the surviving corporation. In
     making the determination of ownership by the stockholders of a corporation,
     immediately after a consolidation, sale or merger, of securities pursuant
     to this Paragraph 6(j), securities which they owned immediately prior to
     such consolidation, sale or merger as stockholders of another party to the
     transaction shall be disregarded.

     7. WAIVER OF RIGHTS TO PURCHASE STOCK.

          By signing this Agreement, Optionee acknowledges and agrees that
     neither the Company nor any other person or entity is under any oral
     obligation to sell or transfer to Optionee any option or equity security of
     the Company. By signing this Agreement, Optionee specifically waives all
     rights which he or she may have had prior to the date of this Agreement
     under any oral agreement or promise by the Company to receive any option or
     equity security of the Company.

     8. INVESTMENT INTENT.

          Optionee represents and agrees that if he or she exercises the Option
     in whole or in part, he or she will acquire the Shares upon such exercise
     for the purpose of investment and not with a view to the distribution of
     such Shares, and that upon each exercise of the Option he or she will
     furnish to the Company a written statement to such effect.

     9. LEGEND ON STOCK CERTIFICATES.

          Optionee agrees that the Company may place on each certificate
     representing the Purchased Shares the following legend:

               THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN
          REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED ("THE ACT"),
          HAVE BEEN TAKEN FOR INVESTMENT, AND MAY NOT BE SOLD, TRANSFERRED,
          ASSIGNED, PLEDGED, HYPOTHECATED OR OTHERWISE DISPOSED OF EXCEPT IN
          ACCORDANCE WITH THE ACT AND THE RULES AND REGULATIONS OF THE
          SECURITIES AND EXCHANGE COMMISSION THEREUNDER.

     10. NO RIGHTS AS STOCKHOLDER.

          Optionee shall have no rights as a stockholder with respect to the
     Shares until the date of the issuance to Optionee of a stock certificate or
     stock certificates evidencing such Shares. Except as may be provided in
     Paragraph 6 of this Agreement, no adjustment shall be made for dividends
     (ordinary or extraordinary, whether in cash, securities or other property)
     or distributions or other rights for which the record date is prior to the
     date such stock certificate is issued.

     11. MODIFICATION.

          The Board or the Administrator may modify, extend or renew the Option
     or accept the surrender of, and authorize the grant of a new option in
     substitution for, the Option (to the extent not previously exercised).


                                  EX-10-1 - 5
<PAGE>


     12. WITHHOLDING.

          (a) The Company shall be entitled to require as a condition of
     delivery of any Purchased Shares upon exercise of any Option that the
     Optionee agree to remit, at the time of such delivery or at such later date
     as the Company may determine, an amount sufficient to satisfy all federal,
     state and local withholding tax requirements relating thereto, and Optionee
     agrees to take such other action required by the Company to satisfy such
     withholding requirements.

          (b) With the consent of the Administrator, and in accordance with any
     rules and procedures from time to time adopted by the Administrator,
     Optionee may elect to satisfy his or her obligations under Paragraph 12(a)
     above by (i) directing the Company to withhold a portion of the Shares
     otherwise deliverable (or to tender back to the Company a portion of the
     Shares issued where the Optionee (a "Section 16(b) Recipient") is required
     to report the ownership of the Shares pursuant to Section 16(a) of the
     Securities Exchange Act of 1934, as amended, and has not made an election
     under Section 83(b) of the Code (a "Withholding Right")); or (ii) tendering
     other shares of the Common Stock of the Company which are already owned by
     Optionee which in all cases have a fair market value (as determined in
     accordance with the provisions of Paragraph 4(b) hereof) on the date as of
     which the amount of tax to be withheld is determined (the "Tax Date") equal
     to the amount of taxes to be paid by such method.

          (c) To exercise a Withholding Right, the Optionee must follow the
     election procedures set forth below, together with such additional
     procedures and conditions set forth in this Option Agreement or otherwise
     adopted by the Administrator:

               (A) the Optionee must deliver to the Company his or her written
          notice of election (the "Election") and specify whether all or a
          stated percentage of the applicable taxes will be paid in accordance
          with Paragraph 12(b) above and whether the amount so paid shall be
          made in accordance with the "flat" withholding rates for supplemental
          wages or as determined in accordance with Optionee's form W-4 (or
          comparable state or local form);

               (B) unless disapproved by the Administrator as provided in
          Subsection (iii) below, the Election once made will be irrevocable;
          and

               (C) no Election is valid unless the Administrator has the right
          and power, in its sole discretion, with or without cause or reason
          therefor, to consent to the Election, to refuse to consent to the
          Election, or to disapprove the Election; and if the Administrator has
          not consented to the Election on or prior to the Tax Date, the
          Election will be deemed approved.

               (D) If the Optionee on the date of delivery of the Election to
          the Company is a Section 16(b) Recipient, the following additional
          provisions will apply:

                    (i) the Election cannot be made during the six calendar
               month period commencing with the date of 9rant of the Withholding
               Right (even if the Option to which such Withholding Right relates
               has been granted prior go such date); and

                    (ii) the Election must be made any day six calendar months
               or more prior to the Tax Date.


                                  EX-10-1 - 6
<PAGE>


     13. CHARACTER OF OPTION.

          The Option is intended to constitute a non-statutory stock option and
     does not constitute an "incentive stock option" as that term is defined in
     Section 422 of the Code.

     14. GENERAL PROVISIONS.

          (a) FURTHER ASSURANCES. Optionee shall promptly take all actions and
     execute all documents requested by the Company which the Company deems to
     be reasonably necessary to effectuate the terms and intent of this Option
     Agreement.

          (b) NOTICES. All notices, requests, demands and other communications
     under this Option Agreement shall be in writing and shall be given to the
     parties hereto as follows:

               (i) If to the Company, to:

                   BIOSOURCE INTERNATIONAL, INC.
                   820 Flynn Road
                   Camarillo, California 93012

               (ii) If to Optionee, to the address set forth in the records of
          the Company,

or at such other address or addresses as may have been furnished by such either
party in writing to the other party hereto. Any such notice, request, demand or
other communication shall be effective (i) if given by mail, 72 hours after such
communication is deposited in the mail by first-class certified mail, return
receipt requested, postage prepaid, addressed as aforesaid, or (ii) if given by
any other means, when delivered at the address specified in this subparagraph
(b).

          (c) TRANSFER OF RIGHTS UNDER THIS OPTION AGREEMENT. The Company may at
     any time transfer and assign its rights and delegate its obligations under
     this Option Agreement to any other person, corporation, firm or entity,
     including its officers, directors and stockholders, with or without
     consideration.

          (d) OPTION NON-TRANSFERABLE. Optionee may not sell, transfer, assign
     or otherwise dispose of the Option except by will or the laws of descent
     and distribution, and only Optionee may exercise the Option during his or
     her lifetime.

          (e) SUCCESSORS AND ASSIGNS. Except to the extent specifically limited
     by the terms and provisions of this Option Agreement, this Option Agreement
     shall be binding upon and inure to the benefit of the parties hereto and
     their respective successors, assigns, heirs and personal representatives.

          (f) GOVERNING LAW. This Option Agreement shall be governed by and
     construed in accordance with the laws of the State of California applicable
     to contracts made in, and to be performed within, that State.

          (g) ATTORNEYS' FEES. In the event that any action, suit or other
     proceeding is instituted upon any breach of this Option Agreement, the
     prevailing party shall be paid by the other party thereto an amount equal
     to all of the prevailing party's costs and expenses, including attorneys'
     fees incurred


                                  EX-10-1 - 7
<PAGE>


     in each and every such action, suit or proceeding (including any and all
     appeals or petitions therefrom). As used in this Option Agreement,
     "attorneys' fees" shall mean the full and actual cost of any legal services
     actually performed in connection with the matter involved calculated on the
     basis of the usual fee charged by the attorney performin9 such services and
     shall not be limited to "reasonable attorneys' fees" as defined in any
     statute or rule of court.

          (h) MISCELLANEOUS. Titles and captions contained in this Option
     Agreement are inserted for convenience of reference only and do not
     constitute a part of this Option Agreement for any other purpose. Except as
     specifically provided herein, neither this Option Agreement nor any right
     pursuant hereto or interest herein shall be assignable to any of the
     parties hereto without the prior written consent of the other party hereto.


                                  EX-10-1 - 8
<PAGE>


     IN WITNESS WHEREOF, the parties hereto have entered into and executed this
Option Agreement as of the date set forth below.

DATED: May 19, 1993


                                        BIOSOURCE INTERNATIONAL, INC.



                                         By: /S/ ANNA ANDERSON
                                             -----------------------------------
                                             Its: CHIEF FINANCIAL OFFICER


                                        OPTIONEE


                                        By:  /S/ JAMES CHAMBERLAIN
                                             -----------------------------------
                                             James H. Chamberlain


                                  EX-10-1 - 9

Exhibit 10.2


                             STOCK OPTION AGREEMENT
                          (NON-STATUTORY STOCK OPTION)

     This STOCK OPTION AGREEMENT (this "Option Agreement") is made and entered
into on the date set forth on the signature page hereof, by and between
BIOSOURCE INTERNATIONAL, INC. ( the "Company"), and James H. Chamberlain
("Optionee").

     The Board of Directors of the Company (the "Board") has authorized the
grant to Optionee of a non-statutory stock option to purchase shares of the
Company's Common Stock, par value $0.001 per share (the "Common Stock"), upon
the terms and subject to the conditions set forth in this Agreement.

     The Company and Optionee agree as follows:

     1. GRANT OF OPTION.

     The Company hereby grants to Optionee the right and option (the "Option"),
upon the terms and subject to the conditions set forth in this Agreement, to
purchase up to 50,000 shares of the Common Stock (the "Shares"), at an Option
Exercise Price (the "Exercise Price") of $2.00 per share.

     2. TERM OF OPTION.

     The Option shall terminate and expire on the date (the "Option Expiration
Date") which is ten years from the date of this Option Agreement, unless sooner
terminated as provided herein.

     3. VESTING.

     The Option shall become immediately exercisable upon execution of this
Agreement.

     4. EXERCISE OF OPTION.

     There is no obligation to exercise the Option, in whole or in part. The
Option may be exercised, in whole or in part, only by delivery to the Company
of:

          (a) written notice of exercise in form and substance identical to
     Exhibit "A" attached to this Option Agreement stating the number of shares
     of Common Stock then being purchased (the "Purchased Shares"); and

          (b) payment of the Exercise Price of the Purchased Shares, either in
     cash, by check, or by transfer to the Company of issued and outstanding
     shares of Common Stock, or by any combination of the above methods of
     payment. If payment is made, in whole or in part, by transfer to the
     Company of issued and outstanding shares of Common Stock, the value of such
     shares shall be determined as follows: (i) if, at the time of payment, the
     Common Stock is traded on the National Market System or any national or
     regional stock exchange, the value of each share shall be the closing sale
     price of a share of Common Stock on the business day immediately preceding
     the payment or, if no sale was made on that date, on the most recent date
     when such a sale was made, as reported on the composite tape for securities
     transactions or similar source for reporting sales of the Common Stock;
     (ii) if, at the time of payment, quotations with respect to the Common
     Stock are made on the NASDAQ System, the value of each share


<PAGE>


     shall be the average of the closing bid and asked quotations of a share of
     Common Stock on the business day immediately preceding the payment or, if
     no quotations were made on that date, on the most recent date when such
     quotations were made; or (iii) if, at the time of payment, neither (i) nor
     (ii) above is applicable, the value of each share shall be the fair market
     value of each share, as determined by the Board or the Administrator.

     Following receipt of the notice and payment referred to above, the Company
shall issue and deliver to Optionee a stock certificate or stock certificates
evidencing the Purchased Shares; PROVIDED, HOWEVER, that the Company shall not
be obligated to issue a fraction or fractions of a share of its Common Stock,
and may pay to Optionee, in cash or by check, the fair market value of any
fraction or fractions of a share exercised by Optionee, which fair market value
shall be determined as set forth in the preceding paragraph.

     5. RESTRICTIONS ON PURCHASED SHARES.

     Optionee shall not sell, transfer (with or without consideration), assign,
pledge, hypothecate or otherwise dispose of (collectively, "Transfer") any of
the Purchased Shares unless and until ALL of the following have occurred:

          (a) The Purchased Shares are disposed of pursuant to and in conformity
     with an effective registration statement filed with the Securities and
     Exchange Commission (the "Commission") pursuant to the Securities Act of
     1933, as amended (the "Act"), or the proposed disposition will not result
     in a violation of the securities laws of any state of the United States;
     and

          (b) If requested by the Company, Optionee shall, prior to the transfer
     of such Purchased Shares, deliver to the Company a written opinion of
     counsel, satisfactory to the Company and its counsel, that the proposed
     disposition will comply with the requirements set forth in clause (a)
     above, in which case, the Company shall bear all reasonable costs of such
     counsel in preparing such opinion.

     Any attempted Transfer which is not in full compliance with this Paragraph
5 shall be null and void AB INITIO, and of no force or effect.

     6. ADJUSTMENTS UPON RECAPITALIZATION.

     Subject to any required action by the stockholders of the Company:

          (a) If outstanding shares of the Common Stock shall be subdivided into
     a greater number of shares of the Common Stock, or a dividend in Shares of
     Common Stock or other securities of the Company convertible into or
     exchangeable for shares of the Common Stock (in which latter event the
     number of shares of Common Stock issuable upon the conversion or exchange
     of such securities shall be deemed to have been distributed) shall be paid
     in respect of the shares of Common Stock, the Exercise Price in effect
     immediately prior to such subdivision or at the record date of such
     dividend shall, simultaneously with the effectiveness of such subdivision
     or immediately after the record date of such dividend, be proportionately
     reduced, and conversely, if the outstanding shares of Common Stock shall be
     combined into a smaller number of shares of Common Stock, the Exercise
     Price in effect immediately prior to such combination shall, simultaneously
     with the effectiveness of such combination, be proportionately increased.


                                  EX-10-2 - 2
<PAGE>


          (b) In the event the Company at any time, or from time to time, shall
     make or issue, or fix a record date for the determination of holders of
     shares of Common Stock entitled to receive, a dividend or other
     distribution payable in securities or the Company other than shares of
     Common Stock or securities convertible into or exchangeable for shares of
     Common Stock then and in each such event, provision shall be made so that
     the holder of the Option shall receive upon exercise thereof, in addition
     to the number of shares receivable thereupon, the amount of securities of
     the Company which he or she would have received had his or her Option been
     exercised on the date of such event and had thereafter, during the period
     from the date of such event to and including the date of exercise, retained
     such securities receivable by him or her as aforesaid during such period,
     giving application to all adjustments called for during such period under
     this Paragraph 6 with respect to the rights of the holder of the Option.

          (c) When any adjustment is required to be made in the Exercise Price,
     the number of Shares purchasable upon the exercise of the Option shall be
     adjusted to that number of Shares determined by (i) multiplying an amount
     equal to the number of Shares purchasable on the exercise of the Option
     immediately prior to such adjustment by the Exercise Price in effect
     immediately prior to such adjustment, and then (ii) dividing that product
     by the Exercise Price in effect immediately after such adjustment.

          (d) In case of any capital reorganization, any reclassification of the
     Common Stock (other than a change in par value or recapitalization
     described in Paragraph 6(a) or 6(b) of this Agreement), or the
     consolidation of the Company with, or a sale of substantially all of the
     assets of the Company to (which sale is followed by a liquidation or
     dissolution of the Company), or merger of the Company with, another person
     where, in each such case, the Company is the "surviving corporation," as
     defined in Paragraph 6(j) below, Optionee shall thereafter be entitled upon
     exercise of the Option to purchase the kind and number of shares of stock
     or other securities or property of the surviving corporation receivable
     upon such event by a holder of the number of shares of the Common Stock
     which the Option entitles Optionee to purchase from the Company any
     immediately prior to such event; and in any such case, appropriate
     adjustment shall be made in the application of the provisions set forth in
     this Agreement with respect to Optionee's rights and interests thereafter,
     to the end that the provisions set forth in this Agreement (including the
     specified changes and other adjustments to the Exercise Price) shall
     thereafter be applicable in relation to any shares or other property
     thereafter purchasable upon exercise of the Option.

          (e) A consolidation of the Company with, or a sale of substantially
     all of the assets of the Company to (which sale is followed by a
     liquidation or dissolution of the Company), or the Merger of the Company
     with, any other person (other than a consolidation, sale or merger in which
     the Company is the "Surviving Corporation," as defined in Paragraph 6 (j)
     below) shall cause the Option to terminate on the Effective Date of such
     consolidation, sale or merger; PROVIDED, HOWEVER, that the Optionee shall
     have the right during a ten day period ending on the fifth day prior to
     such consolidation, sale or merger to exercise the Option, in whole or in
     part, without regard to the installment provision set forth in Paragraph 3
     of this Option Agreement; but any exercise of the Option which except for
     the provisions of this Paragraph 6(e) would not then be exercisable, shall
     be conditioned upon the actual occurrence of such consolidation, sale or
     merger, and if such consolidation, sale of merger is abandoned or otherwise
     does not occur, for any reason, the Optionee's exercise of the Option
     during such ten day period shall be null and void, and of no force and
     effect; PROVIDED, FURTHER, that if such consolidation, sale or merger is to
     be consummated, in whole or in part, by the tender of Common Stock to the
     Surviving Corporation, the Optionee hereby agrees to tender the Shares
     issued upon exercise of his or her Option to the Surviving Corporation, if
     so directed by the board of directors of the Company, and to vote such
     Shares for or against such consolidation, sale or merger, as directed by
     the board of directors of the


                                  EX-10-2 - 3
<PAGE>


     Company. For purposes of this Paragraph 6(e) and subject to the previous
     sentence, any exercise of the Option by optionee pursuant to this Paragraph
     6 shall be deemed to occur immediately prior to the consummation of such
     consolidation, sale or merger.

          (f) If the Company is dissolved or liquidated then the Option shall
     terminate on the effective date of such dissolution or liquidation;
     PROVIDED, HOWEVER, the Optionee shall have the right during a ten day
     period ending on the fifth day prior to such dissolution or liquidation to
     exercise his or her Option in whole or in part, without regard to any of
     the installment provisions set forth in Paragraph 3 of this Agreement; but
     the exercise of the Option which except for the provisions of this
     Paragraph 6(f) would not then be exercisable, shall be conditioned upon the
     actual occurrence of such dissolution or liquidation, and if such
     dissolution or liquidation were not to occur, the Optionee's exercise of
     the Option during such ten day period shall be null and void, and of no
     force and effect. For purposes of the this Paragraph 6(f) and subject to
     the previous sentence, any exercise of the Option by Optionee pursuant to
     this Paragraph 6(f) shall be deemed to occur immediately prior the
     consummation of such dissolution or liquidation.

          (g) To the extent that the foregoing adjustments relate to stock or
     securities of the Company, such adjustments shall be made by the
     Administrator, and its determination shall be final, binding and
     conclusive.

          (h) The provisions of this Paragraph 6 are intended to be exclusive,
     and Optionee shall have no other rights upon the occurrence of any of the
     events described in this Paragraph 6.

          (i) The grant of the Option shall not affect in any way the right or
     power of the Company to make adjustments, reclassifications,
     reorganizations or changes in its capital or business structure, or to
     merge, consolidate, dissolve or liquidate, or to sell or transfer all or
     any part of its business or assets.

          (j) The determination as to which party is the "surviving corporation"
     in a consolidation, sale or merger shall be made on the basis of the
     relative equity interests of the stockholders in the corporation existing
     after the consolidation, sale or merger, as follows: If following any
     consolidation, sale or merger the holders of outstanding voting securities
     of the Company prior to the consolidation, sale or merger own equity
     securities possessing more than 50% of the voting power of the corporation
     existing after the consolidation, sale or merger, then for purposes of this
     Agreement, the Company shall be the surviving corporation. In all other
     cases, the Company shall not be the surviving corporation. In making the
     determination of ownership by the stockholders of a corporation,
     immediately after a consolidation, sale or merger, of securities pursuant
     to this Paragraph 6(j), securities which they owned immediately prior to
     such consolidation, sale or merger as stockholders of another party to the
     transaction shall be disregarded.

     7. WAIVER OF RIGHTS TO PURCHASE STOCK.

     By signing this Agreement, Optionee acknowledges and agrees that neither
the Company nor any other person or entity is under any oral obligation to sell
or transfer to Optionee any option or equity security of the Company. By signing
this Agreement, Optionee specifically waives all rights which he or she may have
had prior to the date of this Agreement under any oral agreement or promise by
the Company to receive any option or equity security of the Company.


                                  EX-10-2 - 4
<PAGE>


     8. INVESTMENT INTENT.

     Optionee represents and agrees that if he or she exercises the Option in
whole or in part, he or she will acquire the Shares upon such exercise for the
purpose of investment and not with a view to the distribution of such Shares,
and that upon each exercise of the Option he or she will furnish to the Company
a written statement to such effect.

     9. LEGEND ON STOCK CERTIFICATES.

     Optionee agrees that the Company may place on each certificate representing
the Purchased Shares the following legend:

          THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
     UNDER THE SECURITIES ACT OF 1933, AS AMENDED ("THE ACT"), HAVE BEEN TAKEN
     FOR INVESTMENT, AND MAY NOT BE SOLD, TRANSFERRED, ASSIGNED, PLEDGED,
     HYPOTHECATED OR OTHERWISE DISPOSED OF EXCEPT IN ACCORDANCE WITH THE ACT AND
     THE RULES AND REGULATIONS OF THE SECURITIES AND EXCHANGE COMMISSION
     THEREUNDER.

     10. NO RIGHTS AS STOCKHOLDER.

     Optionee shall have no rights as a stockholder with respect to the Shares
until the date of the issuance to Optionee of a stock certificate or stock
certificates evidencing such Shares. Except as may be provided in Paragraph 6 of
this Agreement, no adjustment shall be made for dividends (ordinary or
extraordinary, whether in cash, securities or other property) or distributions
or other rights for which the record date is prior to the date such stock
certificate is issued.

     11. MODIFICATION.

     The Board or the Administrator may modify, extend or renew the Option or
accept the surrender of, and authorize the grant of a new option in substitution
for, the Option (to the extent not previously exercised).

     12. WITHHOLDING.

          (a) The Company shall be entitled to require as a condition of
     delivery of any Purchased Shares upon exercise of any Option that the
     Optionee agree to remit, at the time of such delivery or at such later date
     as the Company may determine, an amount sufficient to satisfy all federal,
     state and local withholding tax requirements relating thereto, and Optionee
     agrees to take such other action required by the Company to satisfy such
     withholding requirements.

          (b) With the consent of the Administrator, and in accordance with any
     rules and procedures from time to time adopted by the Administrator,
     Optionee may elect to satisfy his or her obligations under Paragraph 12(a)
     above by (i) directing the Company to withhold a portion of the Shares
     otherwise deliverable (or to tender back to the Company a portion of the
     Shares issued where the Optionee (a "Section 16(b) Recipient") is required
     to report the ownership of the Shares pursuant to Section 16(a) of the
     Securities Exchange Act of 1934, as amended, and has not made an election
     under Section 83(b) of the Code (a "Withholding Right")); or (ii) tendering
     other shares of the Common Stock of the Company


                                  EX-10-2 - 5
<PAGE>


     which are already owned by Optionee which in all cases have a fair market
     value (as determined in accordance with the provisions of Paragraph 4(b)
     hereof) on the date as of which the amount of tax to be withheld is
     determined (the "Tax Date") equal to the amount of taxes to be paid by such
     method.

          (c) To exercise a Withholding Right, the Optionee must follow the
     election procedures set forth below, together with such additional
     procedures and conditions set forth in this Option Agreement or otherwise
     adopted by the Administrator:

               (A) the Optionee must deliver to the Company his or her written
          notice of election (the "Election") and specify whether all or a
          stated percentage of the applicable taxes will be paid in accordance
          with Paragraph 12(b) above and whether the amount so paid shall be
          made in accordance with the "flat" withholding rates for supplemental
          wages or as determined in accordance with Optionee's form W-4 (or
          comparable state or local form);

               (B) unless disapproved by the Administrator as provided in
          Subsection (iii) below, the Election once made will be irrevocable;
          and

               (C) no Election is valid unless the Administrator has the right
          and power, in its sole discretion, with or without cause or reason
          therefor, to consent to the Election, to refuse to consent to the
          Election, or to disapprove the Election; and if the Administrator has
          not consented to the Election on or prior to the Tax Date, the
          Election will be deemed approved.

               (D) If the Optionee on the date of delivery of the Election to
          the Company is a Section 16(b) Recipient, the following additional
          provisions will apply:

                    (i) the Election cannot be made during the six calendar
               month period commencing with the date of 9rant of the Withholding
               Right (even if the Option to which such Withholding Right relates
               has been granted prior go such date); and

                    (ii) the Election must be made any day six calendar months
               or more prior to the Tax Date.

     13. CHARACTER OF OPTION.

          The Option is intended to constitute a non-statutory stock option and
     does not constitute an "incentive stock option" as that term is defined in
     Section 422 of the Code.

     14. GENERAL PROVISIONS.

               (a) FURTHER ASSURANCES. Optionee shall promptly take all actions
          and execute all documents requested by the Company which the Company
          deems to be reasonably necessary to effectuate the terms and intent of
          this Option Agreement.

               (b) NOTICES. All notices, requests, demands and other
          communications under this Option Agreement shall be in writing and
          shall be given to the parties hereto as follows:

                    (i) If to the Company, to:

                         BIOSOURCE INTERNATIONAL, INC.
                         820 Flynn Road
                         Camarillo, California 93012


                                  EX-10-2 - 6
<PAGE>


                    (ii) If to Optionee, to the address set forth in the records
               of the Company,

or at such other address or addresses as may have been furnished by such either
party in writing to the other party hereto. Any such notice, request, demand or
other communication shall be effective (i) if given by mail, 72 hours after such
communication is deposited in the mail by first-class certified mail, return
receipt requested, postage prepaid, addressed as aforesaid, or (ii) if given by
any other means, when delivered at the address specified in this subparagraph
(b).

               (c) TRANSFER OF RIGHTS UNDER THIS OPTION AGREEMENT. The Company
          may at any time transfer and assign its rights and delegate its
          obligations under this Option Agreement to any other person,
          corporation, firm or entity, including its officers, directors and
          stockholders, with or without consideration.

               (d) OPTION NON-TRANSFERABLE. Optionee may not sell, transfer,
          assign or otherwise dispose of the Option except by will or the laws
          of descent and distribution, and only Optionee may exercise the Option
          during his or her lifetime.

               (e) SUCCESSORS AND ASSIGNS. Except to the extent specifically
          limited by the terms and provisions of this Option Agreement, this
          Option Agreement shall be binding upon and inure to the benefit of the
          parties hereto and their respective successors, assigns, heirs and
          personal representatives.

               (f) GOVERNING LAW. This Option Agreement shall be governed by and
          construed in accordance with the laws of the State of California
          applicable to contracts made in, and to be performed within, that
          State.

               (g) ATTORNEYS' FEES. In the event that any action, suit or other
          proceeding is instituted upon any breach of this Option Agreement, the
          prevailing party shall be paid by the other party thereto an amount
          equal to all of the prevailing party's costs and expenses, including
          attorneys' fees incurred in each and every such action, suit or
          proceeding (including any and all appeals or petitions therefrom). As
          used in this Option Agreement, "attorneys' fees" shall mean the full
          and actual cost of any legal services actually performed in connection
          with the matter involved calculated on the basis of the usual fee
          charged by the attorney performin9 such services and shall not be
          limited to "reasonable attorneys' fees" as defined in any statute or
          rule of court.

               (h) MISCELLANEOUS. Titles and captions contained in this Option
          Agreement are inserted for convenience of reference only and do not
          constitute a part of this Option Agreement for any other purpose.
          Except as specifically provided herein, neither this Option Agreement
          nor any right pursuant hereto or interest herein shall be assignable
          to any of the parties hereto without the prior written consent of the
          other party hereto.


                                   EX-10-2 - 7
<PAGE>


     IN WITNESS WHEREOF, the parties hereto have entered into and executed this
Option Agreement as of the date set forth below.

DATED:   May 19, 1993


                                        BIOSOURCE INTERNATIONAL, INC.


                                         By: /S/ ANNA ANDERSON
                                             -----------------------------------
                                             Its: CHIEF FINANCIAL OFFICER


                                        OPTIONEE


                                        By:  /S/ JAMES CHAMBERLAIN
                                             -----------------------------------
                                             James H. Chamberlain


                                   EX-10-2 - 8

Exhibit 10.3


                             STOCK OPTION AGREEMENT
                          (NON-STATUTORY STOCK OPTION)

     This STOCK OPTION AGREEMENT (this "Option Agreement") is made and entered
into on the date set forth on the signature page hereof, by and between
BIOSOURCE INTERNATIONAL, INC. (the "Company"), and James H. Chamberlain
("Optionee").

     The Board of Directors of the Company (the "Board") has authorized the
grant to Optionee of a non-statutory stock option to purchase shares of the
Company's Common Stock, par value $0.001 per share (the "Common Stock"), upon
the terms and subject to the conditions sec forth in this Agreement.

     The Company and Optionee agree as follows:

     1. GRANT OF OPTION.

     The Company hereby grants to Optionee the right and option (the "Option"),
upon the terms and subject to the conditions set forth in this Agreement, to
purchase up to 100,000 shares of the Common Stock (the "Shares"), at an Option
Exercise Price (the "Exercise Price") of $1.50 per share.

     2. TERM OF OPTION.

     The Option shall terminate and expire on the date (the "Option Expiration
Date") which is ten years from the date of this Option Agreement, unless sooner
terminated as provided herein.

     3. VESTING.

     The Option shall become immediately exercisable upon execution of this
Agreement.

     4. EXERCISE OF OPTION.

     There is no obligation to exercise the Option, in whole or in part. The
Option may be exercised, in whole or in part, only by delivery to the Company
of:

          a. written notice of exercise in form and substance identical to
     Exhibit "A" attached to this Option Agreement stating the number of shares
     of Common Stock then being purchased (the "Purchased Shares"); and

          b. payment of the Exercise Price of the Purchased Shares, either in
     cash, by check, or by transfer to the Company of issued and outstanding
     shares of Common Stock, or by any combination of the above methods of
     payment. If payment is made, in whole or in part, by transfer to the
     Company of issued and outstanding shares of Common Stock, the value of such
     shares shall be determined as follows: (i) if, at the time of payment, the
     Common Stock is traded on the National Market System or


<PAGE>


     any national or regional stock exchange, the value of each share shall be
     the closing sale price of a share of Common Stock on the business day
     immediately preceding the payment or, if no sale was made on that date, on
     the most recent date when such a sale was made, as reported on the
     composite tape for securities transactions or similar source for reporting
     sales of the Common Stock; (ii) if, at the time of payment, quotations with
     respect to the Common Stock are made on the NASDAQ System, the value of
     each share shall be the average of the closing bid and asked quotations of
     a share of Common Stock on the business day immediately preceding the
     payment or, if no quotations were made on that date, on the most recent
     date when such quotations were made; or (iii) if, at the time of payment,
     neither (i) nor (ii) above is applicable, the value of each share shall be
     the fair market value of each share, as determined by the Board or the
     Administrator.

     Following receipt of the notice and payment referred to above, the Company
shall issue and deliver to Optionee a stock certificate or stock certificates
evidencing the Purchased Shares; PROVIDED, HOWEVER, that the Company shall not
be obligated to issue a fraction or fractions of a share of its Common Stock,
and may pay to Optionee, in cash or by check, the fair market value of any
fraction or fractions of a share exercised by Optionee, which fair market value
shall be determined as set forth in the preceding paragraph.

     5. RESTRICTIONS ON PURCHASED SHARES.

     Optionee shall not sell, transfer (with or without consideration), assign,
pledge, hypothecate or otherwise dispose of (collectively, "Transfer") any of
the Purchased Shares unless and until all of the following have occurred:

          a. The Purchased Shares are disposed of pursuant to and in conformity
     with an effective registration statement filed with the Securities and
     Exchange Commission {the "Commission") pursuant to the Securities Act of
     1933, as amended (the "Act"), or the proposed disposition will not result
     in a violation of the securities laws of any state of the United States;
     and

          b. If requested by the Company, Optionee shall, prior to the transfer
     of such Purchased Shares, deliver to the Company a written opinion of
     counsel, satisfactory to the Company and its counsel, that the proposed
     disposition will comply with the requirements set forth in clause (a)
     above, in which case, the Company shall bear all reasonable costs of such
     counsel in preparing such opinion.

     Any attempted Transfer which is not in full compliance with this Paragraph
5 shall be null and void AB INITIO, and of no force or effect.

     6. ADJUSTMENTS UPON RECAPITALIZATION.

     Subject to any required action by the stockholders of the Company:

          a. If outstanding shares of the Common Stock shall be subdivided into
     a greater number of shares of the Common Stock, or a dividend in Shares of
     Common Stock or other securities of the Company convertible into or
     exchangeable for shares of the Common Stock (in which latter event the
     number of shares of Common Stock issuable upon the conversion or exchange
     of such securities shall be deemed to have been distributed) shall be paid
     in respect of the shares of Common Stock, the Exercise


                                  EX-10-3 - 2
<PAGE>


     Price in effect immediately prior to such subdivision or at the record date
     of such dividend shall, simultaneously with the effectiveness of such
     subdivision or immediately after the record date of such dividend, be
     proportionately reduced, and conversely, if the outstanding shares of
     Common Stock shall be combined into a smaller number of shares of Common
     Stock, the Exercise Price in effect immediately prior to such combination
     shall, simultaneously with the effectiveness of such combination, be
     proportionately increased.

          b. In the event the Company at any time. or from time to time, shall
     make or issue, or fix a record date for the determination of holders of
     shares of Common Stock entitled to receive, a dividend or other
     distribution payable in securities of the Company other than shares of
     Common Stock or securities convertible into or exchangeable for shares of
     Common Stock then and in each such event, provision shall be made so that
     the holder of the Option shall receive upon exercise thereof, in addition
     to the number of shares receivable thereupon, the amount of securities of
     the Company which he or she would have received had his or her Option been
     exercised on the date of such event and had thereafter, during the period
     from the date of such event to and including the date of exercise, retained
     such securities receivable by him or her as aforesaid during such period,
     giving application to all adjustments called for during such period under
     this Paragraph 6 with respect to the rights of the holder of the Option.

          c. When any adjustment is required to be made in the Exercise Price,
     the number of Shares purchasable upon the exercise of the Option shall be
     adjusted to that number of Shares determined by (i) multiplying an amount
     equal to the number of Shares purchasable on the exercise of the Option
     immediately prior to such adjustment by the Exercise Price in effect
     immediately prior to such adjustment, and then (ii) dividing that product
     by the Exercise Price in effect immediately after such adjustment.

          d. In case of any capital reorganization, any reclassification of the
     Common Stock (other than a change in par value or recapitalization
     described in Paragraph 6(a) or 6(b) of this Agreement), or the
     consolidation of the Company with, or a sale of substantially all of the
     assets of the Company to (which sale is followed by a liquidation or
     dissolution of the Company), or merger of the Company with, another person
     where, in each such case, the Company is the "surviving corporation," as
     defined in Paragraph 6(j) below, Optionee shall thereafter be entitled upon
     exercise of the Option to purchase the kind and number of shares of stock
     or other securities or property of the surviving corporation receivable
     upon such event by a holder of the number of shares of the Common Stock
     which the Option entitles Optionee to purchase from the Company immediately
     prior to such event; and in any such case, appropriate adjustment shall be
     made in the application of the provisions set forth in this Agreement with
     respect to Optionee's rights and interests thereafter, to the end that the
     provisions set forth in this Agreement (including the specified changes and
     other adjustments to the Exercise Price) shall thereafter be applicable in
     relation to any shares or other property thereafter purchasable upon
     exercise of the Option.

          e. A consolidation of the Company with, or a sale of substantially all
     of the assets of the Company to (which sale is followed by a liquidation or
     dissolution of the Company), or the Merger of the Company with, any other
     person (other than a consolidation, sale or merger in which the Company is
     the "Surviving Corporation," as defined in Paragraph 6(j) below) shall
     cause the Option to terminate on the Effective Date of such consolidation,
     sale or merger; PROVIDED, FURTHER, that the Optionee shall have the right
     during a ten day period ending on the fifth day prior to such
     consolidation, sale or merger to exercise the Option, in whole or in part,
     without regard to the installment provision set forth in


                                  EX-10-3 - 3
<PAGE>


     Paragraph 3 of this Option Agreement; but any exercise of the Option which
     except for the provisions of this Paragraph 6(e) would not then be
     exercisable, shall be conditioned upon the actual occurrence of such
     consolidation, sale or merger, and if such consolidation, sale of merger is
     abandoned or otherwise does not occur, for any reason, the Optionee's
     exercise of the Option during such ten day period shall be null and void,
     and of no force and effect; PROVIDED, FURTHER, that if such consolidation,
     sale or merger is to be consummated, in whole or in part, by the tender of
     Common Stock to the Surviving Corporation, the Optionee hereby agrees to
     tender the Shares issued upon exercise of his or her Option to the
     Surviving Corporation, if so directed by the board of directors of the
     Company, and to vote such Shares for or against such consolidation, sale or
     merger, as directed by the board of directors of the Company. For purposes
     of this Paragraph 6(e) and subject to the previous sentence, any exercise
     of the Option by Optionee pursuant to this Paragraph 6 shall be deemed to
     occur immediately prior to the consummation of such consolidation, sale or
     merger.

          f. If the Company is dissolved or liquidated then the Option shall
     terminate on the effective date of such dissolution or liquidation;
     PROVIDED, HOWEVER, the Optionee shall have the right during a ten day
     period ending on the fifth day prior to such dissolution or liquidation to
     exercise his or her Option in whole or in part, without regard to any of
     the installment provisions set forth in Paragraph 3 of this Agreement; but
     the exercise of the Option which except for the provisions of this
     Paragraph 6(f) would not then be exercisable, shall be conditioned upon the
     actual occurrence of such dissolution or liquidation, and if such
     dissolution or liquidation were not to occur, the Optionee's exercise of
     the Option during such ten day period shall be null and void, and of no
     force and effect. For purposes of the this Paragraph 6(f) and subject to
     the previous sentence, any exercise of the Option by Optionee pursuant to
     this Paragraph 6(f) shall be deemed to occur immediately prior the
     consummation of such dissolution or liquidation.

          g. To the extent that the foregoing adjustments relate to stock or
     securities of the Company, such adjustments shall be made by the
     Administrator, and its determination shall be final, binding and
     conclusive.

          h. The provisions of this Paragraph 6 are intended to be exclusive,
     and Optionee shall have no other rights upon the occurrence of any of the
     events described in this Paragraph 6.

          i. The grant of the Option shall not affect in any way the right or
     power of the Company to make adjustments, reclassifications,
     reorganizations or changes in its capital or business structure, or to
     merge, consolidate, dissolve or liquidate, or to sell or transfer all or
     any part of its business or assets.

          j. The determination as to which party is the "surviving corporation"
     in a consolidation, sale or merger shall be made on the basis of the
     relative equity interests of the stockholders in the corporation existing
     after the consolidation, sale or merger, as follows: If following any
     consolidation, sale or merger the holders of outstanding voting securities
     of the Company prior to the consolidation, sale or merger own equity
     securities possessing more than 50% of the voting power of the corporation
     existing after the consolidation, sale or merger, then for purposes of this
     Agreement, the Company shall be the surviving corporation. In all other
     cases, the Company shall not be the surviving corporation. In making the
     determination of ownership by the stockholders of a corporation,
     immediately after a consolidation, sale or merger, of securities pursuant
     to this Paragraph 6(j), securities which they


                                  EX-10-3 - 4
<PAGE>


     owned immediately prior to such consolidation, sale or merger as
     stockholders of another party to the transaction shall be disregarded.

     7. WAIVER OF RIGHTS TO PURCHASE STOCK.

     By signing this Agreement, Optionee acknowledges and agrees that neither
the Company nor any other person or entity is under any oral obligation to sell
or transfer to Optionee any option or equity security of the Company. By signing
this Agreement, optionee specifically waives all rights which he or she may have
had prior to the date of this Agreement under any oral agreement or promise by
the Company to receive any option or equity security of the Company.

     8. INVESTMENT INTENT.

     Optionee represents and agrees that if he or she exercises the Option in
whole or in part, he or she will acquire the Shares upon such exercise for the
purpose of investment and not with a view to the distribution of such Shares,
and that upon each exercise of the Option he or she will furnish to the Company
a written statement to such effect.

     9. LEGEND ON STOCK CERTIFICATES.

     Optionee agrees that the Company may place on each certificate representing
the Purchased Shares the following legend:

          THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
     UNDER THE SECURITIES ACT OF 1933, AS AMENDED ("THE ACT"), HAVE BEEN TAKEN
     FOR INVESTMENT, AND MAY NOT BE SOLD, TRANSFERRED, ASSIGNED, PLEDGED,
     HYPOTHECATED OR OTHERWISE DISPOSED OF EXCEPT IN ACCORDANCE WITH THE ACT AND
     THE RULES AND REGULATIONS OF THE SECURITIES AND EXCHANGE COMMISSION
     THEREUNDER.

     10. NO RIGHTS AS SHAREHOLDERS.

     Optionee shall have no rights as a stockholder with respect to the Shares
until the date of the issuance to Optionee of a stock certificate or stock
certificates evidencing such Shares. Except as may be provided in Paragraph 6 of
this Agreement, no adjustment shall be made for dividends (ordinary or
extraordinary, whether in cash, securities or other property) or distributions
or other rights for which the record date is prior to the date such stock
certificate is issued.

     11. MODIFICATION.

     The Board or the Administrator may modify, extend or renew the Option or
accept the surrender of, and authorize the grant of a new option in substitution
for, the Option (to the extent not previously exercised).


                                  EX-10-3 - 5
<PAGE>


     12. WITHHOLDING.

          a. The Company shall be entitled to require as a condition of delivery
     of any Purchased Shares upon exercise of any Option that the optionee agree
     to remit, at the time of such delivery or at such later date as the Company
     may determine, an amount sufficient to satisfy all federal, state and local
     withholding tax requirements relating thereto, and Optionee agrees to take
     such other action required by the Company to satisfy such withholding
     requirements.

          b. With the consent of the Administrator, and in accordance with any
     rules and procedures from time to time adopted by the Administrator,
     Optionee may elect to satisfy his or her obligations under Paragraph 12(a)
     above by (i) directing the Company to withhold a portion of the Shares
     otherwise deliverable (or to tender back to the Company a portion of the
     Shares issued where the Optionee (a "Section 16(b) Recipient") is required
     to report the ownership of the Shares pursuant to Section 16(a) of the
     Securities Exchange Act of 1934, as amended, and has not made an election
     under Section 83(b) of the Code (a "Withholding Right")); or (ii) tendering
     other shares of the Common Stock of the Company which are already owned by
     Optionee which in all cases have a fair market value (as determined in
     accordance with the provisions of Paragraph 4(b) hereof) on the date as of
     which the amount of tax to be withheld is determined (the "Tax Date") equal
     to the amount of taxes to be paid by such method.

          c. To exercise a Withholding Right, the Optionee must follow the
     election procedures set forth below, together with such additional
     procedures and conditions set forth in this Option Agreement or otherwise
     adopted by the Administrator:

               i. the Optionee must deliver to the Company his or her written
          notice of election (the "Election") and specify whether all or a
          stated percentage of the applicable taxes will be paid in accordance
          with Paragraph 12(b) above and whether the amount so paid shall be
          made in accordance with the "flat" withholding rates for supplemental
          wages or as determined in accordance with Optionee's form W-4 (or
          comparable state or local form);

               ii. unless disapproved by the Administrator as provided in
          Subsection (iii) below, the Election once made will be irrevocable;
          and

               iii. no Election is valid unless the Administrator has the right
          and power, in its sole discretion, with or without cause or reason
          therefor, to consent to the Election, to refuse to consent to the
          Election, or to disapprove the Election; and if the Administrator has
          not consented to the Election on or prior to the Tax Date, the
          Election will be deemed approved.

               iv. If the Optionee on the date of delivery of the Election to
          the Company is a Section 16(b) Recipient, the following additional
          provisions will apply:

                    (1) the Election cannot be made during the six calendar
               month period commencing with the date of grant of the Withholding
               Right (even if the Option to which such Withholding Right relates
               has been granted prior to such date); and


                                  EX-10-3 - 6
<PAGE>


                    (2) the Election must be made any day six calendar months or
               more prior to the Tax Date.

     13.CHARACTER OF OPTION.

     The Option is intended to constitute a non-statutory stock option and DOES
NOT constitute an "incentive stock option" as that term is defined in Section
422 of the Code.

     14.GENERAL PROVISIONS.

          a. FURTHER ASSURANCES. Optionee shall promptly take ail actions and
     execute all documents requested by the Company which the Company deems to
     be reasonably necessary to effectuate the terms and intent of this Option
     Agreement.

          b. NOTICES. All notices, requests, demands and other communications
     under this Option Agreement shall be in writing and shall be given to the
     parties hereto as follows:

               (1) If to the Company, to:

                         BIOSOURCE INTERNATIONAL, INC.
                         820 Flynn Road
                         Camarillo, California 93012

               (2) If to Optionee, to the address set forth in the records of
          the Company,

or at such other address or addresses as may have been furnished by such either
party in writing to the other party hereto. Any such notice, request, demand or
other communication shall be effective (i) if given by mail, 72 hours after such
communication is deposited in the mail by first-class certified mail, return
receipt requested, postage prepaid, addressed as aforesaid, or (ii) if given by
any other means, when delivered at the address specified in this subparagraph
(b).

          c. TRANSFER OF RIGHTS UNDER THIS OPTION AGREEMENT. The Company may at
     any time transfer and assign its rights and delegate its obligations under
     this Option Agreement to any other person, corporation, firm or entity,
     including its officers, directors and stockholders, with or without
     consideration.

          d. OPTION NON-TRANSFERABLE. Optionee may not sell, transfer, assign or
     otherwise dispose of the Option except by will or the laws of descent and
     distribution, and only optionee may exercise the Option during his or her
     lifetime.

          e. SUCCESSORS AND ASSIGNS. Except to the extent specifically limited
     by the terms and provisions of this Option Agreement, this Option Agreement
     shall be binding upon and inure to the benefit of the parties hereto and
     their respective successors, assigns, heirs and personal representatives.


                                  EX-10-3 - 7
<PAGE>


          f. GOVERNING LAW. This Option Agreement shall be governed by and
     construed in accordance with the laws of the State of California applicable
     to contracts made in, and to be performed within, that State.

          g. ATTORNEYS' FEES. In the event that any action, suit or other
     proceeding is instituted upon any breach of this Option Agreement, the
     prevailing party shall be paid by the other party thereto an amount equal
     to all of the prevailing party's costs and expenses, including attorneys'
     fees incurred in each and every such action, suit or proceeding (including
     any and all appeals or petitions therefrom). As used in this Option
     Agreement, "attorneys' fees" shall mean the full and actual cost of any
     legal services actually performed in connection with the matter involved
     calculated on the basis of the usual fee charged by the attorney performing
     such services and shall not be limited to "reasonable attorneys' fees" as
     defined in any statute or rule of court.

          h. MISCELLANEOUS. Titles and captions contained in this Option
     Agreement are inserted for convenience of reference only and do not
     constitute a part of this Option Agreement for any other purpose. Except as
     specifically provided herein, neither this Option Agreement nor any right
     pursuant hereto or interest herein shall be assignable by any of the
     parties hereto without the prior written consent of the other party hereto.

DATED: January 23, 1995

                                        BIOSOURCE INTERNATIONAL, INC.


                                         By: /S/ ANNA ANDERSON
                                             -----------------------------------
                                             Its: CHIEF FINANCIAL OFFICER


                                        OPTIONEE


                                        By:  /S/ JAMES CHAMBERLAIN
                                             -----------------------------------
                                             James H. Chamberlain


                                  EX-10-3 - 8

Exhibit 10.4


                             STOCK OPTION AGREEMENT
                          (NON-STATUTORY STOCK OPTION)

     This STOCK OPTION AGREEMENT (this "Option Agreement") is made and entered
into on the date set forth on the signature page hereof, by and between
BIOSOURCE INTERNATIONAL, INC. ( the "Company"), and James H. Chamberlain
("Optionee").

     The Board of Directors of the Company (the "Board") has authorized the
grant to Optionee of a non-statutory stock option to purchase shares of the
Company's Common Stock, par value $0.001 per share (the "Common Stock"), upon
the terms and subject to the conditions set forth in this Agreement.

     The Company and Optionee agree as follows:

     1. GRANT OF OPTION.

     The Company hereby grants to Optionee the right and option (the "Option"),
upon the terms and subject to the conditions set forth in this Agreement, to
purchase up to 137,500 shares of the Common Stock (the "Shares"), at an Option
Exercise Price (the "Exercise Price") of $5.25 per share.

     2. TERM OF OPTION.

     The Option shall terminate and expire on the date (the "Option Expiration
Date") which is ten years from the date of this Option Agreement, unless sooner
terminated as provided herein.

     3. VESTING.

     The Option shall become immediately exercisable upon execution of this
Agreement.

     4. EXERCISE OF OPTION.

     There is no obligation to exercise the Option, in whole or in part. The
Option may be exercised, in whole or in part, only by delivery to the Company
of:

          (a) written notice of exercise in form and substance identical to
     Exhibit "A" attached to this Option Agreement stating the number of shares
     of Common Stock then being purchased (the "Purchased Shares"); and

          (b) payment of the Exercise Price of the Purchased Shares, either in
     cash, by check, or by transfer to the Company of issued and outstanding
     shares of Common Stock, or by any combination of the above methods of
     payment. If payment is made, in whole or in part, by transfer to the
     Company of issued and outstanding shares of Common Stock, the value of such
     shares shall be determined as follows: (i) if, at the time of payment, the
     Common Stock is traded on the National Market System or any national or
     regional stock exchange, the value of each share shall be the closing sale
     price of a share of Common Stock on the business day immediately preceding
     the payment or, if no sale was made on that date, on the most recent date
     when such a sale was made, as reported on the composite tape for securities
     transactions or similar source for reporting sales of the Common Stock;
     (ii) if, at the time of payment, quotations with respect to the Common
     Stock are made on the NASDAQ System, the value of each share


<PAGE>


     shall be the average of the closing bid and asked quotations of a share of
     Common Stock on the business day immediately preceding the payment or, if
     no quotations were made on that date, on the most recent date when such
     quotations were made; or (iii) if, at the time of payment, neither (i) nor
     (ii) above is applicable, the value of each share shall be the fair market
     value of each share, as determined by the Board or the Administrator.

     Following receipt of the notice and payment referred to above, the Company
shall issue and deliver to Optionee a stock certificate or stock certificates
evidencing the Purchased Shares; PROVIDED, HOWEVER, that the Company shall not
be obligated to issue a fraction or fractions of a share of its Common Stock,
and may pay to Optionee, in cash or by check, the fair market value of any
fraction or fractions of a share exercised by Optionee, which fair market value
shall be determined as set forth in the preceding paragraph.

     5. RESTRICTIONS ON PURCHASED SHARES.

     Optionee shall not sell, transfer (with or without consideration), assign,
pledge, hypothecate or otherwise dispose of (collectively, "Transfer") any of
the Purchased Shares unless and until ALL of the following have occurred:

          (a) The Purchased Shares are disposed of pursuant to and in conformity
     with an effective registration statement filed with the Securities and
     Exchange Commission (the "Commission") pursuant to the Securities Act of
     1933, as amended (the "Act"), or the proposed disposition will not result
     in a violation of the securities laws of any state of the United States;
     and

          (b) If requested by the Company, Optionee shall, prior to the transfer
     of such Purchased Shares, deliver to the Company a written opinion of
     counsel, satisfactory to the Company and its counsel, that the proposed
     disposition will comply with the requirements set forth in clause (a)
     above, in which case, the Company shall bear all reasonable costs of such
     counsel in preparing such opinion.

     Any attempted Transfer which is not in full compliance with this Paragraph
5 shall be null and void AB INITIO, and of no force or effect.

     6. ADJUSTMENTS UPON RECAPITALIZATION.

     Subject to any required action by the stockholders of the Company:

          (a) If outstanding shares of the Common Stock shall be subdivided into
     a greater number of shares of the Common Stock, or a dividend in Shares of
     Common Stock or other securities of the Company convertible into or
     exchangeable for shares of the Common Stock (in which latter event the
     number of shares of Common Stock issuable upon the conversion or exchange
     of such securities shall be deemed to have been distributed) shall be paid
     in respect of the shares of Common Stock, the Exercise Price in effect
     immediately prior to such subdivision or at the record date of such
     dividend shall, simultaneously with the effectiveness of such subdivision
     or immediately after the record date of such dividend, be proportionately
     reduced, and conversely, if the outstanding shares of Common Stock shall be
     combined into a smaller number of shares of Common Stock, the Exercise
     Price in effect immediately prior to such combination shall, simultaneously
     with the effectiveness of such combination, be proportionately increased.


                                  EX-10-4 - 2
<PAGE>


          (b) In the event the Company at any time, or from time to time, shall
     make or issue, or fix a record date for the determination of holders of
     shares of Common Stock entitled to receive, a dividend or other
     distribution payable in securities or the Company other than shares of
     Common Stock or securities convertible into or exchangeable for shares of
     Common Stock then and in each such event, provision shall be made so that
     the holder of the Option shall receive upon exercise thereof, in addition
     to the number of shares receivable thereupon, the amount of securities of
     the Company which he or she would have received had his or her Option been
     exercised on the date of such event and had thereafter, during the period
     from the date of such event to and including the date of exercise, retained
     such securities receivable by him or her as aforesaid during such period,
     giving application to all adjustments called for during such period under
     this Paragraph 6 with respect to the rights of the holder of the Option.

          (c) When any adjustment is required to be made in the Exercise Price,
     the number of Shares purchasable upon the exercise of the Option shall be
     adjusted to that number of Shares determined by (i) multiplying an amount
     equal to the number of Shares purchasable on the exercise of the Option
     immediately prior to such adjustment by the Exercise Price in effect
     immediately prior to such adjustment, and then (ii) dividing that product
     by the Exercise Price in effect immediately after such adjustment.

          (d) In case of any capital reorganization, any reclassification of the
     Common Stock (other than a change in par value or recapitalization
     described in Paragraph 6(a) or 6(b) of this Agreement), or the
     consolidation of the Company with, or a sale of substantially all of the
     assets of the Company to (which sale is followed by a liquidation or
     dissolution of the Company), or merger of the Company with, another person
     where, in each such case, the Company is the "surviving corporation," as
     defined in Paragraph 6(j) below, Optionee shall thereafter be entitled upon
     exercise of the Option to purchase the kind and number of shares of stock
     or other securities or property of the surviving corporation receivable
     upon such event by a holder of the number of shares of the Common Stock
     which the Option entitles Optionee to purchase from the Company any
     immediately prior to such event; and in any such case, appropriate
     adjustment shall be made in the application of the provisions set forth in
     this Agreement with respect to Optionee's rights and interests thereafter,
     to the end that the provisions set forth in this Agreement (including the
     specified changes and other adjustments to the Exercise Price) shall
     thereafter be applicable in relation to any shares or other property
     thereafter purchasable upon exercise of the Option.

          (e) A consolidation of the Company with, or a sale of substantially
     all of the assets of the Company to (which sale is followed by a
     liquidation or dissolution of the Company), or the Merger of the Company
     with, any other person (other than a consolidation, sale or merger in which
     the Company is the "Surviving Corporation," as defined in Paragraph 6 (j)
     below) shall cause the Option to terminate on the Effective Date of such
     consolidation, sale or merger; PROVIDED, HOWEVER, that the Optionee shall
     have the right during a ten day period ending on the fifth day prior to
     such consolidation, sale or merger to exercise the Option, in whole or in
     part, without regard to the installment provision set forth in Paragraph 3
     of this Option Agreement; but any exercise of the Option which except for
     the provisions of this Paragraph 6(e) would not then be exercisable, shall
     be conditioned upon the actual occurrence of such consolidation, sale or
     merger, and if such consolidation, sale of merger is abandoned or otherwise
     does not occur, for any reason, the Optionee's exercise of the Option
     during such ten day period shall be null and void, and of no force and
     effect; PROVIDED, FURTHER, that if such consolidation, sale or merger is to
     be consummated, in whole or in part, by the tender of Common Stock to the
     Surviving Corporation, the Optionee hereby agrees to tender the Shares
     issued upon exercise of his or her Option to the Surviving Corporation, if
     so directed by the board of directors of the Company, and to vote such
     Shares for or against such consolidation, sale or merger, as directed by
     the board of directors of the


                                  EX-10-4 - 3
<PAGE>


     Company. For purposes of this Paragraph 6(e) and subject to the previous
     sentence, any exercise of the Option by optionee pursuant to this Paragraph
     6 shall be deemed to occur immediately prior to the consummation of such
     consolidation, sale or merger.

          (f) If the Company is dissolved or liquidated then the Option shall
     terminate on the effective date of such dissolution or liquidation;
     PROVIDED, HOWEVER, the Optionee shall have the right during a ten day
     period ending on the fifth day prior to such dissolution or liquidation to
     exercise his or her Option in whole or in part, without regard to any of
     the installment provisions set forth in Paragraph 3 of this Agreement; but
     the exercise of the Option which except for the provisions of this
     Paragraph 6(f) would not then be exercisable, shall be conditioned upon the
     actual occurrence of such dissolution or liquidation, and if such
     dissolution or liquidation were not to occur, the Optionee's exercise of
     the Option during such ten day period shall be null and void, and of no
     force and effect. For purposes of the this Paragraph 6(f) and subject to
     the previous sentence, any exercise of the Option by Optionee pursuant to
     this Paragraph 6(f) shall be deemed to occur immediately prior the
     consummation of such dissolution or liquidation.

          (g) To the extent that the foregoing adjustments relate to stock or
     securities of the Company, such adjustments shall be made by the
     Administrator, and its determination shall be final, binding and
     conclusive.

          (h) The provisions of this Paragraph 6 are intended to be exclusive,
     and Optionee shall have no other rights upon the occurrence of any of the
     events described in this Paragraph 6.

          (i) The grant of the Option shall not affect in any way the right or
     power of the Company to make adjustments, reclassifications,
     reorganizations or changes in its capital or business structure, or to
     merge, consolidate, dissolve or liquidate, or to sell or transfer all or
     any part of its business or assets.

          (j) The determination as to which party is the "surviving corporation"
     in a consolidation, sale or merger shall be made on the basis of the
     relative equity interests of the stockholders in the corporation existing
     after the consolidation, sale or merger, as follows: If following any
     consolidation, sale or merger the holders of outstanding voting securities
     of the Company prior to the consolidation, sale or merger own equity
     securities possessing more than 50% of the voting power of the corporation
     existing after the consolidation, sale or merger, then for purposes of this
     Agreement, the Company shall be the surviving corporation. In all other
     cases, the Company shall not be the surviving corporation. In making the
     determination of ownership by the stockholders of a corporation,
     immediately after a consolidation, sale or merger, of securities pursuant
     to this Paragraph 6(j), securities which they owned immediately prior to
     such consolidation, sale or merger as stockholders of another party to the
     transaction shall be disregarded.

     7. WAIVER OF RIGHTS TO PURCHASE STOCK.

     By signing this Agreement, Optionee acknowledges and agrees that neither
the Company nor any other person or entity is under any oral obligation to sell
or transfer to Optionee any option or equity security of the Company. By signing
this Agreement, Optionee specifically waives all rights which he or she may have
had prior to the date of this Agreement under any oral agreement or promise by
the Company to receive any option or equity security of the Company.


                                  EX-10-4 - 4
<PAGE>


     8. INVESTMENT INTENT.

     Optionee represents and agrees that if he or she exercises the Option in
whole or in part, he or she will acquire the Shares upon such exercise for the
purpose of investment and not with a view to the distribution of such Shares,
and that upon each exercise of the Option he or she will furnish to the Company
a written statement to such effect.

     9. LEGEND ON STOCK CERTIFICATES.

     Optionee agrees that the Company may place on each certificate representing
the Purchased Shares the following legend:

          THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
     UNDER THE SECURITIES ACT OF 1933, AS AMENDED ("THE ACT"), HAVE BEEN TAKEN
     FOR INVESTMENT, AND MAY NOT BE SOLD, TRANSFERRED, ASSIGNED, PLEDGED,
     HYPOTHECATED OR OTHERWISE DISPOSED OF EXCEPT IN ACCORDANCE WITH THE ACT AND
     THE RULES AND REGULATIONS OF THE SECURITIES AND EXCHANGE COMMISSION
     THEREUNDER.

     10. NO RIGHTS AS STOCKHOLDER.

     Optionee shall have no rights as a stockholder with respect to the Shares
until the date of the issuance to Optionee of a stock certificate or stock
certificates evidencing such Shares. Except as may be provided in Paragraph 6 of
this Agreement, no adjustment shall be made for dividends (ordinary or
extraordinary, whether in cash, securities or other property) or distributions
or other rights for which the record date is prior to the date such stock
certificate is issued.

     11. MODIFICATION.

     The Board or the Administrator may modify, extend or renew the Option or
accept the surrender of, and authorize the grant of a new option in substitution
for, the Option (to the extent not previously exercised).

     12. WITHHOLDING.

          (a) The Company shall be entitled to require as a condition of
     delivery of any Purchased Shares upon exercise of any Option that the
     Optionee agree to remit, at the time of such delivery or at such later date
     as the Company may determine, an amount sufficient to satisfy all federal,
     state and local withholding tax requirements relating thereto, and Optionee
     agrees to take such other action required by the Company to satisfy such
     withholding requirements.

          (b) With the consent of the Administrator, and in accordance with any
     rules and procedures from time to time adopted by the Administrator,
     Optionee may elect to satisfy his or her obligations under Paragraph 12(a)
     above by (i) directing the Company to withhold a portion of the Shares
     otherwise deliverable (or to tender back to the Company a portion of the
     Shares issued where the Optionee (a "Section 16(b) Recipient") is required
     to report the ownership of the Shares pursuant to Section 16(a) of the
     Securities Exchange Act of 1934, as amended, and has not made an election
     under Section 83(b) of the Code (a "Withholding Right")); or (ii) tendering
     other shares of the Common Stock of the Company


                                  EX-10-4 - 5
<PAGE>


     which are already owned by Optionee which in all cases have a fair market
     value (as determined in accordance with the provisions of Paragraph 4(b)
     hereof) on the date as of which the amount of tax to be withheld is
     determined (the "Tax Date") equal to the amount of taxes to be paid by such
     method.

          (c) To exercise a Withholding Right, the Optionee must follow the
     election procedures set forth below, together with such additional
     procedures and conditions set forth in this Option Agreement or otherwise
     adopted by the Administrator:

               (A) the Optionee must deliver to the Company his or her written
          notice of election (the "Election") and specify whether all or a
          stated percentage of the applicable taxes will be paid in accordance
          with Paragraph 12(b) above and whether the amount so paid shall be
          made in accordance with the "flat" withholding rates for supplemental
          wages or as determined in accordance with Optionee's form W-4 (or
          comparable state or local form);

               (B) unless disapproved by the Administrator as provided in
          Subsection (iii) below, the Election once made will be irrevocable;
          and

               (C) no Election is valid unless the Administrator has the right
          and power, in its sole discretion, with or without cause or reason
          therefor, to consent to the Election, to refuse to consent to the
          Election, or to disapprove the Election; and if the Administrator has
          not consented to the Election on or prior to the Tax Date, the
          Election will be deemed approved.

               (D) If the Optionee on the date of delivery of the Election to
          the Company is a Section 16(b) Recipient, the following additional
          provisions will apply:

                    (i) the Election cannot be made during the six calendar
               month period commencing with the date of 9rant of the Withholding
               Right (even if the Option to which such Withholding Right relates
               has been granted prior go such date); and

                    (ii) the Election must be made any day six calendar months
               or more prior to the Tax Date.

     13. CHARACTER OF OPTION.

     The Option is intended to constitute a non-statutory stock option and does
not constitute an "incentive stock option" as that term is defined in Section
422 of the Code.

     14. GENERAL PROVISIONS.

          (a) FURTHER ASSURANCES. Optionee shall promptly take all actions and
     execute all documents requested by the Company which the Company deems to
     be reasonably necessary to effectuate the terms and intent of this Option
     Agreement.

          (b) NOTICES. All notices, requests, demands and other communications
     under this Option Agreement shall be in writing and shall be given to the
     parties hereto as follows:

               (i) If to the Company, to:

                    BIOSOURCE INTERNATIONAL, INC.
                    820 Flynn Road
                    Camarillo, California 93012


                                  EX-10-4 - 6
<PAGE>


               (ii) If to Optionee, to the address set forth in the records of
          the Company,

or at such other address or addresses as may have been furnished by such either
party in writing to the other party hereto. Any such notice, request, demand or
other communication shall be effective (i) if given by mail, 72 hours after such
communication is deposited in the mail by first-class certified mail, return
receipt requested, postage prepaid, addressed as aforesaid, or (ii) if given by
any other means, when delivered at the address specified in this subparagraph
(b).

          (c) TRANSFER OF RIGHTS UNDER THIS OPTION AGREEMENT. The Company may at
     any time transfer and assign its rights and delegate its obligations under
     this Option Agreement to any other person, corporation, firm or entity,
     including its officers, directors and stockholders, with or without
     consideration.

          (d) OPTION NON-TRANSFERABLE. Optionee may not sell, transfer, assign
     or otherwise dispose of the Option except by will or the laws of descent
     and distribution, and only Optionee may exercise the Option during his or
     her lifetime.

          (e) SUCCESSORS AND ASSIGNS. Except to the extent specifically limited
     by the terms and provisions of this Option Agreement, this Option Agreement
     shall be binding upon and inure to the benefit of the parties hereto and
     their respective successors, assigns, heirs and personal representatives.

          (f) GOVERNING LAW. This Option Agreement shall be governed by and
     construed in accordance with the laws of the State of California applicable
     to contracts made in, and to be performed within, that State.

          (g) ATTORNEYS' FEES. In the event that any action, suit or other
     proceeding is instituted upon any breach of this Option Agreement, the
     prevailing party shall be paid by the other party thereto an amount equal
     to all of the prevailing party's costs and expenses, including attorneys'
     fees incurred in each and every such action, suit or proceeding (including
     any and all appeals or petitions therefrom). As used in this Option
     Agreement, "attorneys' fees" shall mean the full and actual cost of any
     legal services actually performed in connection with the matter involved
     calculated on the basis of the usual fee charged by the attorney performin9
     such services and shall not be limited to "reasonable attorneys' fees" as
     defined in any statute or rule of court.

          (h) MISCELLANEOUS. Titles and captions contained in this Option
     Agreement are inserted for convenience of reference only and do not
     constitute a part of this Option Agreement for any other purpose. Except as
     specifically provided herein, neither this Option Agreement nor any right
     pursuant hereto or interest herein shall be assignable to any of the
     parties hereto without the prior written consent of the other party hereto.


                                  EX-10-4 - 7
<PAGE>


     IN WITNESS WHEREOF, the parties hereto have entered into and executed this
Option Agreement as of the date set forth below.

DATED: January 3, 1996


                                        BIOSOURCE INTERNATIONAL, INC.



                                         By: /S/ ANNA ANDERSON
                                             -----------------------------------
                                             Its: CHIEF FINANCIAL OFFICER


                                        OPTIONEE


                                        By:  /S/ JAMES CHAMBERLAIN
                                             -----------------------------------
                                             James H. Chamberlain


                                  EX-10-4 - 8

Exhibit 10.5


                             STOCK OPTION AGREEMENT
                          (NON-STATUTORY STOCK OPTION)

     This STOCK OPTION AGREEMENT (this "Option Agreement") is made and entered
into on the execution date of the Option Certificate to which it is attached
(the "Certificate"), by and between BioSource International, Inc., a California
corporation (the "Company"), and GUS DAVIS ("Optionee").

     The Board of Directors of the Company (the "Board") has authorized the
grant to Optionee of a non-statutory stock option to purchase shares of the
Company's Common Stock, par value $0.001 per share (the "Common Stock"), upon
the terms and subject to the conditions set forth in this Agreement.

     The Company and Optionee agree as follows:

     15. GRANT OF OPTION.

     The Company hereby grants to Optionee the right and option (the "Option"),
upon the terms and subject to the conditions set forth in this Option Agreement,
to purchase up to 30,000 SHARES of the Common Stock (the "Shares"), at the
Option Exercise Price (the "Exercise Price") of $1.688 per share.

     16. TERM OF OPTION.

     The Option shall terminate and expire on the date (the "Option Expiration
Date") which is ten years from the date of this Option Agreement, unless sooner
terminated as provided herein.

     17. VESTING.

     The Option shall become immediately exercisable upon execution of this
Agreement.

     18. EXERCISE OF OPTION.

     There is no obligation to exercise the Option, in whole or in part. The
Option may be exercised, in whole or in part, only by delivery to the Company
of:

          a. written notice of exercise in form and substance identical to
     Exhibit "A" attached to this Option Agreement stating the number of shares
     of Common Stock then being purchased (the "Purchased Shares"); and

          b. payment of the Exercise Price of the Purchased Shares, either in
     cash, by check, or by transfer to the Company of issued and outstanding
     shares of Common Stock, or by any combination of the above methods of
     payment. If payment is made, in whole or in part, by transfer to the
     Company of issued and outstanding shares of Common Stock, the value of such
     shares shall be determined as follows: (i) if, at the time of payment, the
     Common Stock is traded on the National Market System or any national or
     regional stock exchange, the value of each share shall be the closing sale
     price of a share of Common Stock on the business day immediately preceding
     the payment or, if no sale was made on that date, on the most recent date
     when such a sale was made, as reported on the composite tape for securities
     transactions or similar source for reporting sales of the Common Stock; or
     (ii) if, at the time of payment, quotations with respect to the Common
     Stock are made on the NASDAQ System, the value of each share shall be


<PAGE>


     the average of the closing bid and asked quotations of a share of Common
     Stock on the business day immediately preceding the payment or, if no
     quotations were made on that date, on the most recent date when such
     quotations were made; or (iii) if, at the time of payment, neither (i) nor
     (ii) above is applicable, the value of each share shall be the fair market
     value of each share, as determined by the Board or the Administrator.

     Following receipt of the notice and payment referred to above, the Company
shall issue and deliver to Optionee a stock certificate or stock certificates
evidencing the Purchased Shares; PROVIDED, HOWEVER, that the Company shall not
be obligated to issue a fraction or fractions of a share of its Common Stock,
and may pay to Optionee, in cash or by check, the fair market value of any
fraction or fractions of a share exercised by Optionee, which fair market value
shall be determined as set forth in the preceding paragraph.

     19. RESTRICTIONS ON PURCHASED SHARES.

     Optionee shall not sell, transfer (with or without consideration), assign,
pledge, hypothecate or otherwise dispose of (collectively, "Transfer" any of the
Purchased Shares unless and until ALL of the following events shall have
occurred:

          a. the Purchased Shares are disposed of pursuant to and in conformity
     with an effective registration statement filed with the Securities and
     Exchange Commission (the "Commission") pursuant to the Securities Act of
     1933, as amended (the "Act"), or the proposed disposition will not result
     in a violation of the securities laws of any state of the United States;
     and

          b. If requested by the Company, Optionee shall, prior to the transfer
     of such Purchased Shares, deliver to the Company a written opinion of
     counsel, satisfactory to the Company and its counsel, that the proposed
     disposition will comply with the requirements set forth in clause (a)
     above, in which case, the Company shall bear all reasonable costs of such
     counsel in preparing such opinion.

     Any attempted Transfer which is not in full compliance with this Paragraph
5 shall be null and void AB INITIO, and of no force or effect.

     20. ADJUSTMENTS UPON RECAPITALIZATION.

     Subject to any required action by the stockholders of the Company:

          a. If outstanding shares of the Common Stock shall be subdivided into
     a greater number of shares of the Common Stock, or a dividend in Shares of
     Common Stock or other securities of the Company convertible into or
     exchangeable for shares of the Common Stock (in which latter event the
     number of shares of Common Stock issuable upon the conversion or exchange
     of such securities shall be deemed to have been distributed) shall be paid
     in respect of the shares of Common Stock, the Exercise Price in effect
     immediately prior to such subdivision or at the record date of such
     dividend shall, simultaneously with the effectiveness of such subdivision
     or immediately after the record date of such dividend, be proportionately
     reduced, and conversely, if the outstanding shares of Common Stock shall be
     combined into a smaller number of shares of Common Stock, the Exercise
     Price in effect immediately prior to such combination shall, simultaneously
     with the effectiveness of such combination, be proportionately increased.

          b. In the event the Company at any time, or from time to time, shall
     make or issue, or fix a record date for the determination of holders of
     shares of Common Stock entitled to receive, a dividend


                                  EX-10-5 - 2
<PAGE>


     or other distribution payable in securities of the Company other than
     shares of Common Stock or securities convertible into or exchangeable for
     shares of Common Stock then and in each such event, provision shall be made
     so that the holder of the Option shall receive upon exercise thereof, in
     addition to the number of shares receivable thereupon, the amount of
     securities of the Company which he or she would have received had his or
     her Option been exercised on the date of such event and had thereafter,
     during the period from the date of such event to and including the date of
     exercise, retained such securities receivable by him or her as aforesaid
     during such period, giving application to all adjustments called for during
     such period under this Paragraph 6 with respect to the rights of the holder
     of the Option.

          c. When any adjustment is required to be made in the Exercise Price,
     the number of Shares purchasable upon the exercise of the Option shall be
     adjusted to that number of Shares determined by (i) multiplying an amount
     equal to the number of Shares purchasable on the exercise of the Option
     immediately prior to such adjustment by the Exercise Price in effect
     immediately prior to such adjustment, and then (ii) dividing that product
     by the Exercise Price in effect immediately after such adjustment.

          d. In case of any capital reorganization, any reclassification of the
     Common Stock (other than a change in par value or recapitalization
     described in Paragraph 6(a) or 6(b) of this Agreement), or the
     consolidation of the Company with, or a sale of substantially all of the
     assets of the Company to (which sale is followed by a liquidation or
     dissolution of the Company), or merger of the Company with, another person
     where, in each such case, the Company is the "surviving corporation," as
     defined in Paragraph 6(j) below, Optionee shall thereafter be entitled upon
     exercise of the Option to purchase the kind and number of shares of stock
     or other securities or property of the surviving corporation receivable
     upon such event by a holder of the number of shares of the Common Stock
     which the Option entitles Optionee to purchase from the Company immediately
     prior to such event; and in any such case, appropriate adjustment shall be
     made in the application of the provisions set forth in this Agreement with
     respect to Optionee's rights and interests thereafter, to the end that the
     provisions set forth in this Agreement (including the specified changes and
     other adjustments to the Exercise Price) shall thereafter be applicable in
     relation to any shares or other property thereafter purchasable upon
     exercise of the Option.

          e. A consolidation of the Company with, or a sale of substantially all
     of the assets of the Company to (which sale is followed by a liquidation or
     dissolution of the Company), or the Merger of the Company with, any other
     person (other than a consolidation, sale or merger in which the Company is
     the "Surviving Corporation," as defined in Paragraph 6(j) below) shall
     cause the Option to terminate on the Effective Date of such consolidation,
     sale or merger; PROVIDED, HOWEVER, that the Optionee shall have the right
     during a ten day period ending on the fifth day prior to such
     consolidation, sale or merger to exercise the Option, in whole or in part,
     without regard to the installment provision set forth in Paragraph 3 of
     this Option Agreement; but any exercise of the Option which except for the
     provisions of this Paragraph 6(e) would not then be exercisable, shall be
     conditioned upon the actual occurrence of such consolidation, sale or
     merger, and if such consolidation, sale of merger is abandoned or otherwise
     does not occur, for any reason, the Optionee's exercise of the Option
     during such ten day period shall be null and void, and of no force and
     effect; PROVIDED, FURTHER, that if such consolidation, sale or merger is to
     be consummated, in whole or in part, by the tender of Common Stock to the
     Surviving Corporation, the Optionee hereby agrees to tender the Shares
     issued upon exercise of his or her Option to the Surviving Corporation, if
     so directed by the board of directors of the Company, and to vote such
     Shares for or against such consolidation, sale or merger, as directed by
     the board of directors of the Company. For purposes of this Paragraph 6(e)
     and subject to the previous sentence, any exercise of the Option by
     Optionee pursuant to this Paragraph 6 shall be deemed no occur immediately
     prior to the consummation of such consolidation, sale or merger.


                                  EX-10-5 - 3
<PAGE>


          f. If the Company is dissolved or liquidated then the Option shall
     terminate on the effective date of such dissolution or liquidation;
     PROVIDED, HOWEVER, the Optionee shall have the right during a ten day
     period ending on the fifth day prior to such dissolution or liquidation to
     exercise his or her Option in whole or in part, without regard to any of
     the installment provisions set forth in Paragraph 3 of this Agreement; but
     the exercise of the Option which except for the provisions of this
     Paragraph 6(f) would not then be exercisable, shall be conditioned upon the
     actual occurrence of such dissolution or liquidation, and if such
     dissolution or liquidation were not to occur, the Optionee's exercise of
     the Option during such ten day period shall be null and void, and of no
     force and effect. For purposes of the this Paragraph 6(f) and subject to
     the previous sentence, any exercise of the Option by Optionee pursuant to
     this Paragraph 6(f) shall be deemed to occur immediately prior to the
     consummation of such dissolution or liquidation.

          g. To the extent that the foregoing adjustments relate to stock or
     securities of the Company, such adjustments shall be made by the
     Administrator, and its determination shall be final, binding and
     conclusive.

          h. The provisions of this Paragraph 6 are intended to be exclusive,
     and Optionee shall have no other rights upon the occurrence of any of the
     events described in this Paragraph 6.

          i. The grant of the Option shall not affect in any way the right or
     power of the Company to make adjustments, reclassifications,
     reorganizations or changes in its capital or business structure, or to
     merge, consolidate, dissolve or liquidate, or to sell or transfer all or
     any part of its business or assets.

          j. The determination as to which party is the "surviving corporation"
     in a consolidation, sale or merger shall be made on the basis of the
     relative equity interests of the stockholders in the corporation existing
     after the consolidation, sale or merger, as follows: If following any
     consolidation, sale or merger the holders of outstanding voting securities
     of the Company prior to the consolidation, sale or merger own equity
     securities possessing more than 50% of the voting power of the corporation
     existing after the consolidation, sale or merger, then for purposes of this
     Agreement, the Company shall be the surviving corporation. In all other
     cases, the Company shall not be the surviving corporation. In making the
     determination of ownership by the stockholders of a corporation,
     immediately after a consolidation, sale or merger, of securities pursuant
     to this Paragraph 6(j), securities which they owned immediately prior to
     such consolidation, sale or merger as stockholders of another party to the
     transaction shall be disregarded.

     21. WAIVER OF RIGHTS TO PURCHASE STOCK.

     By signing this Agreement, Optionee acknowledges and agrees that neither
the Company nor any other person or entity is under any oral obligation to sell
or transfer to Optionee any option or equity security of the Company. By signing
this Agreement, Optionee specifically waives all rights which he or she may have
had prior to the date of this Agreement under any oral agreement or promise by
the Company to receive any option or equity security of the Company.

     22. INVESTMENT INTENT.

     Optionee represents and agrees that if he or she exercises the Option in
whole or in part, he or she will acquire the Shares upon such exercise for the
purpose of investment and not with a view to the distribution of such Shares,
and that upon each exercise of the Option he or she will furnish to the Company
a written statement to such effect.


                                  EX-10-5 - 4
<PAGE>


     23. LEGEND ON STOCK CERTIFICATES. Optionee agrees that the Company may
place on each certificate representing the Purchased Shares the following
legend:

          THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
     UNDER THE SECURITIES ACT OF 1933, AS AMENDED ("THE ACT"), HAVE BEEN TAKEN
     FOR INVESTMENT, AND MAY NOT BE SOLD, TRANSFERRED, ASSIGNED, PLEDGED,
     HYPOTHECATED OR OTHERWISE DISPOSED OF EXCEPT IN ACCORDANCE WITH THE ACT AND
     THE RULES AND REGULATIONS OF THE SECURITIES AND EXCHANGE COMMISSION
     THEREUNDER.

     24. NO RIGHTS AS STOCKHOLDER.

     Optionee shall have no rights as a stockholder with respect to the Shares
until the date of the issuance to Optionee of a stock certificate or stock
certificates evidencing such Shares. Except as may be provided in Paragraph 6 of
this Agreement, no adjustment shall be made for dividends (ordinary or
extraordinary, whether in cash, securities or other property) or distributions
or other rights for which the record date is prior to the date such stock
certificate is issued.

     25. MODIFICATION.

     The Board or the Administrator may modify, extend or renew the Option or
accept the surrender of, and authorize the grant of a new option in substitution
for, the Option (to the extent not previously exercised).

     26. WITHHOLDING.

          a. The Company shall be entitled to require as a condition of delivery
     of any Purchased Shares upon exercise of any Option that the Optionee agree
     to remit, at the time of such delivery or at such later date as the Company
     may determine, an amount sufficient to satisfy all federal, state and local
     withholding tax requirements relating thereto, and Optionee agrees to take
     such other action required by the Company to satisfy such withholding
     requirements.

          b. With the consent of the Administrator, and in accordance with any
     rules and procedures from time to time adopted by the Administrator,
     Optionee may elect to satisfy his or her obligations under Paragraph 12(a)
     above by (i) directing the Company to withhold a portion of the Shares
     otherwise deliverable (or to tender back to the Company a portion of the
     Shares issued where the Optionee (a "Section 16(b) Recipient") is required
     to report the ownership of the Shares pursuant to Section 16(a) of the
     Securities Exchange Act of 1934, as amended, and has not made an election
     under Section 83(b) of the Code (a "Withholding Right")); or (ii) tendering
     other shares of the Common Stock of the Company which are already owned by
     Optionee which in all cases have a fair market value (as determined in
     accordance with the provisions of Paragraph 4(b) hereof) on the date as of
     which the amount of tax to be withheld is determined (the "Tax Date") equal
     to the amount of taxes to be paid by such method.

          c. To exercise a Withholding Right, the Optionee must follow the
     election procedures set forth below, together with such additional
     procedures and conditions set forth in this Option Agreement or otherwise
     adopted by the Administrator:


                                  EX-10-5 - 5
<PAGE>


               i. the Optionee must deliver to the Company his or her written
          notice of election (the "Election") and specify whether all or a
          stated percentage of the applicable taxes will be paid in accordance
          with Paragraph 12(b) above and whether the amount so paid shall be
          made in accordance with the "flat" withholding rates for supplemental
          wages or as determined in accordance with Optionee's form W-4 (or
          comparable state or local form);

               ii. unless disapproved by the Administrator as provided in
          Subsection (iii) below, the Election once made will be irrevocable;
          and

               iii. no Election is valid unless the Administrator has the right
          and power, in its sole discretion, with or without cause or reason
          therefor, to consent to the Election, to refuse to consent to the
          Election, or to disapprove the Election; and if the Administrator has
          not consented to the Election on or prior to the Tax Date, the
          Election will be deemed approved.

               iv. If the Optionee on the date of delivery of the Election to
          the Company is a Section 16(b) Recipient, the following additional
          provisions will apply:

                    (1) the Election cannot be made during the six calendar
               month period commencing with the date of grant of the Withholding
               Right (even if the Option to which such Withholding Right relates
               has been granted prior to such date); and

                    (2) the Election must be made any day six calendar months or
               more prior to the Tax Date.

     27. CHARACTER OF OPTION

      The Option is intended to constitute a non-statutory stock option and DOES
NOT constitute an "incentive stock option" as that term is defined in Section
422 of the Code.

     28. GENERAL PROVISIONS.

          a. FURTHER ASSURANCES. Optionee shall promptly take all actions and
     execute all documents requested by the Company which the Company deems to
     be reasonably necessary to effectuate the terms and intent of this Option
     Agreement.

          b. NOTICES. All notices, requests, demands and other communications
     under this Option Agreement shall be in writing and shall be given to the
     parties hereto as follows:

               (1) If to the Company, to:

                   BIOSOURCE INTERNATIONAL, INC.
                   820 Flynn Road
                   Camarillo, California 93012

               (2) If to Optionee, to the address set forth in the records of
          the Company,

or at such other address or addresses as may have been furnished by such either
party in writing to the other party hereto. Any such notice, request, demand or
other communication shall be effective (i) if given


                                  EX-10-5 - 6
<PAGE>


by mail, 72 hours after such communication is deposited in the mail by
first-class certified mail, return receipt requested, postage prepaid, addressed
as aforesaid, or (ii) if given by any other means, when delivered at the address
specified in this subparagraph (b).

          c. TRANSFER OF RIGHTS UNDER THIS OPTION AGREEMENT. The Company may at
     any time transfer and assign its rights and delegate its obligations under
     this Option Agreement to any other person, corporation, firm or entity,
     including its officers, directors and stockholders, with or without
     consideration.

          d. OPTION NON-TRANSFERABLE. Optionee may not sell, transfer, assign or
     otherwise dispose of the Option except by will or the laws of descent and
     distribution, and only Optionee may exercise the Option during his or her
     lifetime.

          e. SUCCESSORS AND ASSIGNS. Except to the extent specifically limited
     by the terms and provisions of this Option Agreement, this Option Agreement
     shall be binding upon and inure to the benefit of the parties hereto and
     their respective successors, assigns, heirs and personal representatives.

          f. GOVERNING LAW. This option agreement shall be governed by and
     construed in accordance with the laws of the State of California applicable
     to contracts made in, and to be performed within, that state.

          g. ATTORNEYS' FEES. In the event that any action, suit or other
     proceeding is instituted upon any breach of this Option Agreement, the
     prevailing party shall be paid by the other party thereto an amount equal
     to all of the prevailing party's costs and expenses, including attorneys'
     fees incurred in each and every such action, suit or proceeding (including
     any and all appeals or petitions therefrom). As used in this Option
     Agreement, "attorneys' fees" shall mean the full and actual cost of any
     legal services actually performed in connection with the matter involved
     calculated on the basis of the usual fee charged by the attorney performing
     such services and shall not be limited to "reasonable attorneys' fees" as
     defined in any statute or rule of court.

          h. MISCELLANEOUS. Titles and captions contained in this Option
     Agreement are inserted, for convenience of reference only and do not
     constitute a part of this Option Agreement for any other purpose. Except as
     specifically provided herein, neither this Option Agreement nor any right
     pursuant hereto or interest herein shall be assignable by any of the
     parties hereto without the prior written consent of the other party hereto.

     IN WITNESS WHEREOF, the parties hereto have entered into and executed this
Option Agreement as of the date set forth below.

DATED: June 1, 1995

                                       BIOSOURCE INTERNATIONAL, INC.


                                        By:  /S/ JAMES CHAMBERLAIN
                                             -----------------------------------
                                             Its: Chief Executive Officer


                                       OPTIONEE


                                        By:  /S/ GUS DAVIS
                                             -----------------------------------
                                             Gus Davis


                                  EX-10-5 - 7

Exhibit 10.6


                             STOCK OPTION AGREEMENT
                          (NON-STATUTORY STOCK OPTION)

     This STOCK OPTION AGREEMENT (this "Option Agreement") is made and entered
into on the date set forth on the signature page hereof, by and between
BIOSOURCE INTERNATIONAL, INC. ( the "Company"), and Robert Weist ("Optionee").

     The Board of Directors of the Company (the "Board") has authorized the
grant to Optionee of a non-statutory stock option to purchase shares of the
Company's Common Stock, par value $0.001 per share (the "Common Stock"), upon
the terms and subject to the conditions set forth in this Agreement.

     The Company and Optionee agree as follows:

     1. GRANT OF OPTION.

     The Company hereby grants to Optionee the right and option (the "Option"),
upon the terms and subject to the conditions set forth in this Agreement, to
purchase up to 10,000 shares of the Common Stock (the "Shares"), at an Option
Exercise Price (the "Exercise Price") of $6.4375 per share.

     2. TERM OF OPTION.

     The Option shall terminate and expire on the date (the "Option Expiration
Date") which is ten years from the date of this Option Agreement, unless sooner
terminated as provided herein.

     3. VESTING.

     The Option shall become immediately exercisable upon execution of this
Agreement.

     4. EXERCISE OF OPTION.

     There is no obligation to exercise the Option, in whole or in part. The
Option may be exercised, in whole or in part, only by delivery to the Company
of:

          (a) written notice of exercise in form and substance identical to
     Exhibit "A" attached to this Option Agreement stating the number of shares
     of Common Stock then being purchased (the "Purchased Shares"); and

          (b) payment of the Exercise Price of the Purchased Shares, either in
     cash, by check, or by transfer to the Company of issued and outstanding
     shares of Common Stock, or by any combination of the above methods of
     payment. If payment is made, in whole or in part, by transfer to the
     Company of issued and outstanding shares of Common Stock, the value of such
     shares shall be determined as follows: (i) if, at the time of payment, the
     Common Stock is traded on the National Market System or any national or
     regional stock exchange, the value of each share shall be the closing sale
     price of a share of Common Stock on the business day immediately preceding
     the payment or, if no sale was made on that date, on the most recent date
     when such a sale was made, as reported on the composite tape for securities
     transactions or similar source for reporting sales of the Common Stock;
     (ii) if, at the time of payment, quotations with respect to the Common
     Stock are made on the NASDAQ System, the value of each share


                                  EX-10-6 - 1
<PAGE>


     shall be the average of the closing bid and asked quotations of a share of
     Common Stock on the business day immediately preceding the payment or, if
     no quotations were made on that date, on the most recent date when such
     quotations were made; or (iii) if, at the time of payment, neither (i) nor
     (ii) above is applicable, the value of each share shall be the fair market
     value of each share, as determined by the Board or the Administrator.

     Following receipt of the notice and payment referred to above, the Company
shall issue and deliver to Optionee a stock certificate or stock certificates
evidencing the Purchased Shares; PROVIDED, HOWEVER, that the Company shall not
be obligated to issue a fraction or fractions of a share of its Common Stock,
and may pay to Optionee, in cash or by check, the fair market value of any
fraction or fractions of a share exercised by Optionee, which fair market value
shall be determined as set forth in the preceding paragraph.

     5. RESTRICTIONS ON PURCHASED SHARES.

     Optionee shall not sell, transfer (with or without consideration), assign,
pledge, hypothecate or otherwise dispose of (collectively, "Transfer") any of
the Purchased Shares unless and until ALL of the following have occurred:

          (a) The Purchased Shares are disposed of pursuant to and in conformity
     with an effective registration statement filed with the Securities and
     Exchange Commission (the "Commission") pursuant to the Securities Act of
     1933, as amended (the "Act"), or the proposed disposition will not result
     in a violation of the securities laws of any state of the United States;
     and

          (b) If requested by the Company, Optionee shall, prior to the transfer
     of such Purchased Shares, deliver to the Company a written opinion of
     counsel, satisfactory to the Company and its counsel, that the proposed
     disposition will comply with the requirements set forth in clause (a)
     above, in which case, the Company shall bear all reasonable costs of such
     counsel in preparing such opinion.

     Any attempted Transfer which is not in full compliance with this Paragraph
5 shall be null and void AB INITIO, and of no force or effect.

     6. ADJUSTMENTS UPON RECAPITALIZATION.

     Subject to any required action by the stockholders of the Company:

          (a) If outstanding shares of the Common Stock shall be subdivided into
     a greater number of shares of the Common Stock, or a dividend in Shares of
     Common Stock or other securities of the Company convertible into or
     exchangeable for shares of the Common Stock (in which latter event the
     number of shares of Common Stock issuable upon the conversion or exchange
     of such securities shall be deemed to have been distributed) shall be paid
     in respect of the shares of Common Stock, the Exercise Price in effect
     immediately prior to such subdivision or at the record date of such
     dividend shall, simultaneously with the effectiveness of such subdivision
     or immediately after the record date of such dividend, be proportionately
     reduced, and conversely, if the outstanding shares of Common Stock shall be
     combined into a smaller number of shares of Common Stock, the Exercise
     Price in effect immediately prior to such combination shall, simultaneously
     with the effectiveness of such combination, be proportionately increased.


                                  EX-10-6 - 2
<PAGE>


          (b) In the event the Company at any time, or from time to time, shall
     make or issue, or fix a record date for the determination of holders of
     shares of Common Stock entitled to receive, a dividend or other
     distribution payable in securities or the Company other than shares of
     Common Stock or securities convertible into or exchangeable for shares of
     Common Stock then and in each such event, provision shall be made so that
     the holder of the Option shall receive upon exercise thereof, in addition
     to the number of shares receivable thereupon, the amount of securities of
     the Company which he or she would have received had his or her Option been
     exercised on the date of such event and had thereafter, during the period
     from the date of such event to and including the date of exercise, retained
     such securities receivable by him or her as aforesaid during such period,
     giving application to all adjustments called for during such period under
     this Paragraph 6 with respect to the rights of the holder of the Option.

          (c) When any adjustment is required to be made in the Exercise Price,
     the number of Shares purchasable upon the exercise of the Option shall be
     adjusted to that number of Shares determined by (i) multiplying an amount
     equal to the number of Shares purchasable on the exercise of the Option
     immediately prior to such adjustment by the Exercise Price in effect
     immediately prior to such adjustment, and then (ii) dividing that product
     by the Exercise Price in effect immediately after such adjustment.

          (d) In case of any capital reorganization, any reclassification of the
     Common Stock (other than a change in par value or recapitalization
     described in Paragraph 6(a) or 6(b) of this Agreement), or the
     consolidation of the Company with, or a sale of substantially all of the
     assets of the Company to (which sale is followed by a liquidation or
     dissolution of the Company), or merger of the Company with, another person
     where, in each such case, the Company is the "surviving corporation," as
     defined in Paragraph 6(j) below, Optionee shall thereafter be entitled upon
     exercise of the Option to purchase the kind and number of shares of stock
     or other securities or property of the surviving corporation receivable
     upon such event by a holder of the number of shares of the Common Stock
     which the Option entitles Optionee to purchase from the Company any
     immediately prior to such event; and in any such case, appropriate
     adjustment shall be made in the application of the provisions set forth in
     this Agreement with respect to Optionee's rights and interests thereafter,
     to the end that the provisions set forth in this Agreement (including the
     specified changes and other adjustments to the Exercise Price) shall
     thereafter be applicable in relation to any shares or other property
     thereafter purchasable upon exercise of the Option.

          (e) A consolidation of the Company with, or a sale of substantially
     all of the assets of the Company to (which sale is followed by a
     liquidation or dissolution of the Company), or the Merger of the Company
     with, any other person (other than a consolidation, sale or merger in which
     the Company is the "Surviving Corporation," as defined in Paragraph 6 (j)
     below) shall cause the Option to terminate on the Effective Date of such
     consolidation, sale or merger; PROVIDED, HOWEVER, that the Optionee shall
     have the right during a ten day period ending on the fifth day prior to
     such consolidation, sale or merger to exercise the Option, in whole or in
     part, without regard to the installment provision set forth in Paragraph 3
     of this Option Agreement; but any exercise of the Option which except for
     the provisions of this Paragraph 6(e) would not then be exercisable, shall
     be conditioned upon the actual occurrence of such consolidation, sale or
     merger, and if such consolidation, sale of merger is abandoned or otherwise
     does not occur, for any reason, the Optionee's exercise of the Option
     during such ten day period shall be null and void, and of no force and
     effect; PROVIDED, FURTHER, that if such consolidation, sale or merger is to
     be consummated, in whole or in part, by the tender of Common Stock to the
     Surviving Corporation, the Optionee hereby agrees to tender the Shares
     issued upon exercise of his or her Option to the Surviving Corporation, if
     so directed by the board of directors of the Company, and to vote such
     Shares for or against such consolidation, sale or merger, as directed by
     the board of directors of the


                                  EX-10-6 - 3
<PAGE>


     Company. For purposes of this Paragraph 6(e) and subject to the previous
     sentence, any exercise of the Option by optionee pursuant to this Paragraph
     6 shall be deemed to occur immediately prior to the consummation of such
     consolidation, sale or merger.

          (f) If the Company is dissolved or liquidated then the Option shall
     terminate on the effective date of such dissolution or liquidation;
     PROVIDED, HOWEVER, the Optionee shall have the right during a ten day
     period ending on the fifth day prior to such dissolution or liquidation to
     exercise his or her Option in whole or in part, without regard to any of
     the installment provisions set forth in Paragraph 3 of this Agreement; but
     the exercise of the Option which except for the provisions of this
     Paragraph 6(f) would not then be exercisable, shall be conditioned upon the
     actual occurrence of such dissolution or liquidation, and if such
     dissolution or liquidation were not to occur, the Optionee's exercise of
     the Option during such ten day period shall be null and void, and of no
     force and effect. For purposes of the this Paragraph 6(f) and subject to
     the previous sentence, any exercise of the Option by Optionee pursuant to
     this Paragraph 6(f) shall be deemed to occur immediately prior the
     consummation of such dissolution or liquidation.

          (g) To the extent that the foregoing adjustments relate to stock or
     securities of the Company, such adjustments shall be made by the
     Administrator, and its determination shall be final, binding and
     conclusive.

          (h) The provisions of this Paragraph 6 are intended to be exclusive,
     and Optionee shall have no other rights upon the occurrence of any of the
     events described in this Paragraph 6.

          (i) The grant of the Option shall not affect in any way the right or
     power of the Company to make adjustments, reclassifications,
     reorganizations or changes in its capital or business structure, or to
     merge, consolidate, dissolve or liquidate, or to sell or transfer all or
     any part of its business or assets.

          (j) The determination as to which party is the "surviving corporation"
     in a consolidation, sale or merger shall be made on the basis of the
     relative equity interests of the stockholders in the corporation existing
     after the consolidation, sale or merger, as follows: If following any
     consolidation, sale or merger the holders of outstanding voting securities
     of the Company prior to the consolidation, sale or merger own equity
     securities possessing more than 50% of the voting power of the corporation
     existing after the consolidation, sale or merger, then for purposes of this
     Agreement, the Company shall be the surviving corporation. In all other
     cases, the Company shall not be the surviving corporation. In making the
     determination of ownership by the stockholders of a corporation,
     immediately after a consolidation, sale or merger, of securities pursuant
     to this Paragraph 6(j), securities which they owned immediately prior to
     such consolidation, sale or merger as stockholders of another party to the
     transaction shall be disregarded.

     7. WAIVER OF RIGHTS TO PURCHASE STOCK.

     By signing this Agreement, Optionee acknowledges and agrees that neither
the Company nor any other person or entity is under any oral obligation to sell
or transfer to Optionee any option or equity security of the Company. By signing
this Agreement, Optionee specifically waives all rights which he or she may have
had prior to the date of this Agreement under any oral agreement or promise by
the Company to receive any option or equity security of the Company.


                                  EX-10-6 - 4
<PAGE>


     8. INVESTMENT INTENT.

     Optionee represents and agrees that if he or she exercises the Option in
whole or in part, he or she will acquire the Shares upon such exercise for the
purpose of investment and not with a view to the distribution of such Shares,
and that upon each exercise of the Option he or she will furnish to the Company
a written statement to such effect.

     9. LEGEND ON STOCK CERTIFICATES.

     Optionee agrees that the Company may place on each certificate representing
the Purchased Shares the following legend:

          THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
     UNDER THE SECURITIES ACT OF 1933, AS AMENDED ("THE ACT"), HAVE BEEN TAKEN
     FOR INVESTMENT, AND MAY NOT BE SOLD, TRANSFERRED, ASSIGNED, PLEDGED,
     HYPOTHECATED OR OTHERWISE DISPOSED OF EXCEPT IN ACCORDANCE WITH THE ACT AND
     THE RULES AND REGULATIONS OF THE SECURITIES AND EXCHANGE COMMISSION
     THEREUNDER.

     10. NO RIGHTS AS STOCKHOLDER.

     Optionee shall have no rights as a stockholder with respect to the Shares
until the date of the issuance to Optionee of a stock certificate or stock
certificates evidencing such Shares. Except as may be provided in Paragraph 6 of
this Agreement, no adjustment shall be made for dividends (ordinary or
extraordinary, whether in cash, securities or other property) or distributions
or other rights for which the record date is prior to the date such stock
certificate is issued.

     11. MODIFICATION.

     The Board or the Administrator may modify, extend or renew the Option or
accept the surrender of, and authorize the grant of a new option in substitution
for, the Option (to the extent not previously exercised).

     12. WITHHOLDING.

          (a) The Company shall be entitled to require as a condition of
     delivery of any Purchased Shares upon exercise of any Option that the
     Optionee agree to remit, at the time of such delivery or at such later date
     as the Company may determine, an amount sufficient to satisfy all federal,
     state and local withholding tax requirements relating thereto, and Optionee
     agrees to take such other action required by the Company to satisfy such
     withholding requirements.

          (b) With the consent of the Administrator, and in accordance with any
     rules and procedures from time to time adopted by the Administrator,
     Optionee may elect to satisfy his or her obligations under Paragraph 12(a)
     above by (i) directing the Company to withhold a portion of the Shares
     otherwise deliverable (or to tender back to the Company a portion of the
     Shares issued where the Optionee (a "Section 16(b) Recipient") is required
     to report the ownership of the Shares pursuant to Section 16(a) of the
     Securities Exchange Act of 1934, as amended, and has not made an election
     under Section 83(b) of the Code (a "Withholding Right")); or (ii) tendering
     other shares of the Common Stock of the Company


                                  EX-10-6 - 5
<PAGE>


     which are already owned by Optionee which in all cases have a fair market
     value (as determined in accordance with the provisions of Paragraph 4(b)
     hereof) on the date as of which the amount of tax to be withheld is
     determined (the "Tax Date") equal to the amount of taxes to be paid by such
     method.

          (c) To exercise a Withholding Right, the Optionee must follow the
     election procedures set forth below, together with such additional
     procedures and conditions set forth in this Option Agreement or otherwise
     adopted by the Administrator:

               (A) the Optionee must deliver to the Company his or her written
          notice of election (the "Election") and specify whether all or a
          stated percentage of the applicable taxes will be paid in accordance
          with Paragraph 12(b) above and whether the amount so paid shall be
          made in accordance with the "flat" withholding rates for supplemental
          wages or as determined in accordance with Optionee's form W-4 (or
          comparable state or local form);

               (B) unless disapproved by the Administrator as provided in
          Subsection (iii) below, the Election once made will be irrevocable;
          and

               (C) no Election is valid unless the Administrator has the right
          and power, in its sole discretion, with or without cause or reason
          therefor, to consent to the Election, to refuse to consent to the
          Election, or to disapprove the Election; and if the Administrator has
          not consented to the Election on or prior to the Tax Date, the
          Election will be deemed approved.

               (D) If the Optionee on the date of delivery of the Election to
          the Company is a Section 16(b) Recipient, the following additional
          provisions will apply:

                    (i) the Election cannot be made during the six calendar
               month period commencing with the date of 9rant of the Withholding
               Right (even if the Option to which such Withholding Right relates
               has been granted prior go such date); and

                    (ii) the Election must be made any day six calendar months
               or more prior to the Tax Date.

     13. CHARACTER OF OPTION.

     The Option is intended to constitute a non-statutory stock option and does
not constitute an "incentive stock option" as that term is defined in Section
422 of the Code.

     14. GENERAL PROVISIONS.

          (a) FURTHER ASSURANCES. Optionee shall promptly take all actions and
     execute all documents requested by the Company which the Company deems to
     be reasonably necessary to effectuate the terms and intent of this Option
     Agreement.

          (b) NOTICES. All notices, requests, demands and other communications
     under this Option Agreement shall be in writing and shall be given to the
     parties hereto as follows:

               (i) If to the Company, to:

                   BIOSOURCE INTERNATIONAL, INC.
                   820 Flynn Road
                   Camarillo, California 93012


                                  EX-10-6 - 6
<PAGE>


               (ii) If to Optionee, to the address set forth in the records of
          the Company,

or at such other address or addresses as may have been furnished by such either
party in writing to the other party hereto. Any such notice, request, demand or
other communication shall be effective (i) if given by mail, 72 hours after such
communication is deposited in the mail by first-class certified mail, return
receipt requested, postage prepaid, addressed as aforesaid, or (ii) if given by
any other means, when delivered at the address specified in this subparagraph
(b).

          (c) TRANSFER OF RIGHTS UNDER THIS OPTION AGREEMENT. The Company may at
     any time transfer and assign its rights and delegate its obligations under
     this Option Agreement to any other person, corporation, firm or entity,
     including its officers, directors and stockholders, with or without
     consideration.

          (d) OPTION NON-TRANSFERABLE. Optionee may not sell, transfer, assign
     or otherwise dispose of the Option except by will or the laws of descent
     and distribution, and only Optionee may exercise the Option during his or
     her lifetime.

          (e) SUCCESSORS AND ASSIGNS. Except to the extent specifically limited
     by the terms and provisions of this Option Agreement, this Option Agreement
     shall be binding upon and inure to the benefit of the parties hereto and
     their respective successors, assigns, heirs and personal representatives.

          (f) GOVERNING LAW. This Option Agreement shall be governed by and
     construed in accordance with the laws of the State of California applicable
     to contracts made in, and to be performed within, that State.

          (g) ATTORNEYS' FEES. In the event that any action, suit or other
     proceeding is instituted upon any breach of this Option Agreement, the
     prevailing party shall be paid by the other party thereto an amount equal
     to all of the prevailing party's costs and expenses, including attorneys'
     fees incurred in each and every such action, suit or proceeding (including
     any and all appeals or petitions therefrom). As used in this Option
     Agreement, "attorneys' fees" shall mean the full and actual cost of any
     legal services actually performed in connection with the matter involved
     calculated on the basis of the usual fee charged by the attorney performin9
     such services and shall not be limited to "reasonable attorneys' fees" as
     defined in any statute or rule of court.

          (h) MISCELLANEOUS. Titles and captions contained in this Option
     Agreement are inserted for convenience of reference only and do not
     constitute a part of this Option Agreement for any other purpose. Except as
     specifically provided herein, neither this Option Agreement nor any right
     pursuant hereto or interest herein shall be assignable to any of the
     parties hereto without the prior written consent of the other party hereto.


                                  EX-10-6 - 7
<PAGE>


     IN WITNESS WHEREOF, the parties hereto have entered into and executed this
Option Agreement as of the date set forth below.

DATED: April 5, 1996

                                       BIOSOURCE INTERNATIONAL, INC.


                                        By:  /S/ JAMES CHAMBERLAIN
                                             -----------------------------------
                                             Its: Chief Executive Officer


                                       OPTIONEE


                                        By:  /S/ ROBERT WEIST
                                             -----------------------------------
                                             Robert Weist


                                  EX-10-6 - 8

Exhibit 10.7


                               OPTION CERTIFICATE
                          (NON-STATUTORY STOCK OPTION)

     THIS IS TO CERTIFY that BioSource International, Inc., a Delaware
corporation (the "Company"), has granted to the person named below a
non-statutory stock option (the "Option") to purchase shares of the Company's
Common Stock, par value $0.001 per share (the. "Shares"), as follows:

Name of Optionee:       David S. Fishman

Address of Optionee:    36 Angelica Drive
                        Framingham, Massachusetts 01701

Number of Shares:       25,000

Option Exercise Price:  12 13/16

Option Expiration Date: December 8, 2008

     EXERCISE SCHEDULE: The Option shall become exercisable as follows: the
option to purchase 12,500 shares vests on December 9, 1999 and the option to
purchase an additional 12,500 shares vests on December 9, 2000 (the "Vesting
Date").

     SUMMARY OF OTHER TERMS: This Option is defined in the Stock Option
Agreement (Non-Statutory Stock Option) (the "Option Agreement") which is
attached to this Option Certificate (the "Certificate") as Annex I. This
Certificate summarizes certain of the provisions of the Option Agreement for
your information, but is not complete. Your rights are governed by the Option
Agreement, not by this Summary. The Company strongly suggests that you carefully
review the full Option Agreement prior to signing this Certificate or exercising
the Option.

     Among the terms of the Option Agreement are the following:

     EMPLOYMENT: Unless otherwise provided in your Consulting Agreement with the
Company, dated as of December 9, 1998 ("Consulting Agreement"), the Option
Agreement obligates you to work for the Company (or hold office if you are a
director) for one (1) year from the Date of Grant of the Option. Note, however,
that should you fail to do so, the Company's sole remedy is to cancel the
portion of your Option which is not then exercisable


<PAGE>


(unless otherwise provided in your Consulting Agreement). The Option Agreement
does not obligate the Company to retain you for one (1) year. See Paragraph 3
and the Exercise Schedule, above. Unless otherwise agreed in writing, the
Company reserves the right to terminate any employee or consultant at any time,
with or without cause.

     TERMINATION OF EMPLOYMENT: Unless otherwise provided in your Consulting
Agreement, while the Option terminates on the Option Expiration Date, it will
terminate earlier if you cease to be employed by the Company (or hold office if
you are a director).

     TRANSFER: The Option is personal to you, and cannot be sold, transferred,
assigned or otherwise disposed of to any other person, except on your death. See
Paragraph 15(d).

     EXERCISE: You can exercise the Option (once it is exercisable), in whole or
in part, by delivering to the Company a Notice of Exercise identical to Exhibit
"A" attached to the Option Agreement, accompanied by payment of the Exercise
Price for the Shares to be purchased. The Company will then issue a certificate
to you for the Shares you have purchased. You are under no obligation to
exercise the Option. See Paragraph 4.

     ANTI-DILUTION PROVISIONS: The Option contains provisions which adjust your
Option to reflect stock splits, stock dividends, mergers and other major
corporate reorganizations which would change the nature of the Shares underlying
your Option. See Paragraph 7.

     WAIVER: By signing this Certificate, you will be agreeing to all of the
terms of the Option Agreement, including those not summarized in this
Certificate. You will waive your rights to options or stock which may have been
promised to you. See Paragraph 8.

     WITHHOLDING: The Company may require you to make any arrangements necessary
to insure the proper withholding of any amount of tax, if any, required to be
withheld by the Company as a result of the exercise of the Option. See Paragraph
13.


                                  EX-10-7 - 2
<PAGE>


                                    AGREEMENT

     BioSource International, Inc., a Delaware corporation (the "COMPANY"), and
the above-named person (the "OPTIONEE") each hereby agrees to be bound by all of
the terms and conditions of the Stock Option Agreement (Incentive Stock Option)
which is attached hereto as Annex I and incorporated herein by this reference as
if set forth in full is this document.

DATED: December 9, 1998

                                       BIOSOURCE INTERNATIONAL, INC.


                                       By:   /S/ JAMES CHAMBERLAIN
                                             -----------------------------------
                                             Its: President & Chief Executive
                                                  Officer


                                       By:  /S/ DAVID S. FISHMAN
                                             -----------------------------------
                                             Employee Signature

                                              -------------------------------
                                              (Please print your name exactly
                                              as you wish it to appear on any
                                             stock certificates issued to you
                                               upon exercise of the Option)


                                  EX-10-7 - 3
<PAGE>


                                     ANNEX I

                             STOCK OPTION AGREEMENT
                          (Non-Statutory Stock Option)

     This STOCK OPTION AGREEMENT (this "Option Agreement") is made and entered
into on the execution date of the Option Certificate to which it is attached
(the "Certificate"), by and between BioSource International, Inc., a Delaware
corporation (the "Company"), and the person named in the Certificate
("Optionee").

     The Board of Directors of the Company (the "Board") has authorized the
grant to Optionee of a non-statutory stock option to purchase shares of the
Company's Common Stock, par value $0.001 per share (the "Common Stock"), upon
the terms and subject to the conditions set forth in this Option Agreement.

     The Company and Optionee agree as follows:

     1. Grant of Option.

     The Company hereby grants to Optionee the right and option (the "Option"),
upon the terms and subject to the conditions set forth in this Option Agreement,
to purchase all or any portion of that number of shares of the Common Stock (the
"Shares") set forth in the Certificate, at the Option exercise price set forth
in the Certificate (the "Exercise Price").

     2. Term of Option.

     The Option shall terminate and expire on the Option Expiration Date set
forth in the Certificate, unless sooner terminated as provided herein.

     3. Exercise Period.

          (a) Subject to the provisions of Paragraphs 3(b), 5, 7(c) and 7(d) of
     this Option Agreement and except as otherwise provided in your Consulting
     Agreement with the Company (the "Consulting Agreement"), the Option shall
     become exercisable (in whole or in part) upon and after the dates set forth
     under the caption "Exercise Schedule" in the Certificate. The installments
     shall be cumulative; i.e., the Option may be exercised, as to any or all
     Shares covered by an installment, at any time or times after the
     installment first becomes exercisable and until expiration or termination
     of the Option.

          (b) Notwithstanding anything to the contrary, contained in this Option
     Agreement, the Option may not be exercised, in whole or in part, unless and
     until any then-


                                  EX-10-7 - 4
<PAGE>


applicable requirements of all federal, state and local laws and regulatory
agencies shall have been fully complied with to the satisfaction of the Company
and its counsel.

     4. Exercise of Option.

     There is no obligation to exercise the Option, in whole or in part. The
Option may be exercised, in whole or in part, only by delivery to the Company
of:

          (a) written notice of exercise in form and substance identical to
     Exhibit "A" attached to this Option Agreement stating the number of shares
     of Common Stock then being purchased (the "Purchased Shares"); and

          (b) payment of the Exercise Price of the Purchased Shares, either in
     cash, by check, by cancellation of any indebtedness of the Company to
     Optionee for accrued and unpaid salary or, with the consent of the Board
     (or a committee thereof), by transfer to the Company of issued and
     outstanding shares of Common Stock which have been held by Optionee for a
     period of at least six calendar months preceding the date of surrender and
     which have a fair market value equal to the exercise price, or by any
     combination of the above methods of payment. If payment is made, in whole
     or in part, by transfer to the Company of issued and outstanding shares of
     Common Stock, the value of such shares shall be determined as follows: (i)
     if the Stock is listed on an exchange or exchanges, or admitted for trading
     in a market system which provides last sale data under Rule 11Aa3-1 of the
     General Rules and Regulations of the Securities and Exchange Commission
     under the Securities and Exchange Act of 1934, as amended (a "Market
     System"), the last reported sales price per share on the last business day
     prior to such date on the principal exchange on which it is traded, or in
     such a Market System, as applicable, or if no sale was made on such day on
     such principal exchange or in such a Market System, as applicable, the last
     reported sales price per share on the most recent day prior to such date on
     which a sale was reported on such exchange or such Market System, as
     applicable; or (ii) if the Common Stock is not then traded on an exchange
     or in such a Market System, the average of the closing bid and asked prices
     per share for the Common Stock in the over-the-counter market as quoted on
     NASDAQ on the day prior to such date; or (iii) if the Common Stock is not
     listed on an exchange or quoted on NASDAQ, an amount determined in good
     faith by the Board (or a committee thereof).

     Following receipt of the notice and payment referred to above, the Company
shall issue and deliver to Optionee a stock certificate or stock certificates
evidencing the Purchased Shares; provided, however, that the Company shall not
be obligated to issue a fraction or o fractions of a share of its Common Stock,
and may pay to Optionee, in cash or by check, the fair market value of any
fraction or fractions of a share exercised by Optionee, which fair market value
shall be determined as set forth in the preceding paragraph.


                                  EX-10-7 - 5
<PAGE>


     5. Termination of Employment/Consultancy.

     Unless otherwise provided in your Consulting Agreement, if Optionee shall
cease to be a Director of the Company, or to be in the employ of, or a
consultant to the Company, any Subsidiary or any Parent by reason of Optionee's
death, permanent disability, or retirement (a "Special Terminating Event"), then
Optionee, Optionee's executors or administrators or any person or persons
acquiring the Option directly from Optionee by bequest or inheritance, shall
have the right to exercise the Option with respect to all Shares granted under
the Option at any time after such Special Terminating Event.

     6. Restrictions on Purchased Shares.

     None of the Purchased Shares shall be transferred (with or without
consideration), sold, offered for sale, assigned, pledged, hypothecated or
otherwise disposed of (each a "Transfer") and the Company shall not be required
to register any such Transfer and the Company may instruct its transfer agent
not to register any such Transfer, unless and until all of the following events
shall have occurred:

          (a) the Purchased Shares are Transferred pursuant to and in conformity
     with (i) (x) an effective registration statement filed with the Securities
     and Exchange Commission (the "Commission") pursuant to the Securities Act
     of 1933, as amended (the "Act"), or (y) an exemption from registration
     under the Act; and (ii) the securities laws of any state of the United
     States; and

          (b) Optionee has, prior to the Transfer of such Purchased Shares,
     provided all relevant information to Company's counsel so that upon
     Company's request, Company's counsel is able to, and actually prepares and
     delivers to the Company a written opinion that the proposed Transfer (i)
     (x) is pursuant to a registration statement which has been filed with the
     Commission and is then effective, or (y) is exempt from registration under
     the Act as then in effect, and the Rules and Regulations of the Commission
     thereunder; and (ii) is either qualified or registered under any applicable
     state securities laws, or exempt from such qualification or registration.
     The Company shall bear all reasonable costs of preparing such opinion.

     Any attempted Transfer which is not in full compliance with this Paragraph
6 shall be null and void ab initio, and of no force or effect.

     7. Adjustments upon Recapitalization.

     Subject to any required action by the shareholders of the Company:

          (a) If the outstanding shares of the Common Stock shall be subdivided
     into a greater number of shares of the Common Stock, or a dividend in
     shares of Common Stock


                                  EX-10-7 - 6
<PAGE>


     or other securities of the Company convertible into or exchangeable for
     shares of the Common Stock (in which latter event the number of shares of
     Common Stock issuable upon the conversion or exchange of such securities
     shall be deemed to have been distributed) shall be paid in respect of the
     shares of Common Stock, the Exercise Price in effect immediately prior to
     such subdivision or at the record date of such dividend shall,
     simultaneously with the effectiveness of such subdivision or immediately
     after the record date of such dividend, be proportionately reduced, and
     conversely, if the outstanding shares of Common Stock shall be combined
     into a smaller number of shares of Common Stock, the Exercise Price in
     effect immediately prior to such combination shall, simultaneously with the
     effectiveness of such combination, be proportionately increased.

          (b) When any adjustment is required to be made in the Exercise Price,
     the number of Shares purchasable upon the exercise of the Option shall be
     adjusted to that number of Shares determined by (i) multiplying an amount
     equal to the number of Shares purchasable on the exercise of the Option
     immediately prior to such adjustment by the Exercise Price in effect
     immediately prior to such adjustment, and then (ii) dividing that product
     by the Exercise Price in effect immediately after such adjustment.

          (c) In case of any capital reorganization, any reclassification of the
     Common Stock (other than a change in par value or recapitalization
     described in Paragraph 7(a) of this Option Agreement), or the consolidation
     of the Company with, or a sale of substantially all of the assets of the
     Company to (which sale is followed by a liquidation or dissolution of the
     Company), or merger of the Company with another person (a "Reorganization
     Event"), the Board (or a committee thereof) shall be obligated to determine
     whether the Reorganization Event shall constitute a "Liquidity Event," and
     to deliver to Optionee at least 15 days prior to such Reorganization Event
     a notice which shall (i) indicate whether the Reorganization Event is a
     Liquidity Event; (ii) indicate whether the Liquidity Event shall result in
     the acceleration of the vesting provisions of this Option; and (iii) advise
     Optionee of his or her rights pursuant to this Option Agreement. If the
     Reorganization Event is determined to be a Liquidity Event, in its sole and
     absolute discretion, the surviving corporation may, but shall not be
     obligated .to, (i) tender to Optionee Stock Options with respect to the
     surviving corporation which shall contain terms and provisions that
     substantially preserve the rights and benefits of this Option, and (ii) in
     the event that no Stock Options have been tendered by the surviving
     corporation pursuant to the terms of item (i) immediately above, Optionee
     shall have the right exercisable during a ten-day period ending on the
     fifth day prior to the Reorganization Event (or ending on the fifth day
     prior to the date of record for shareholders entitled to share in the
     securities or property distributed in the Reorganization Event, if a record
     date is set) to exercise his or her Stock Options in whole or in part, and
     if so determined by the Board (or a committee thereof), without regard to
     any installment provisions under his or her Stock Option Agreement, on the
     condition, however, that the Reorganization Event is actually


                                  EX-10-7 - 7
<PAGE>


     effected; and if the Reorganization Event is actually effected, such
     exercise shall be deemed effective (and, if applicable, the Optionee shall
     be deemed a shareholder with respect to the Stock Options exercised)
     immediately preceding the effective time of the Reorganization Event (or on
     the date of record for shareholders entitled to share in the securities or
     property distributed in the Reorganization Event, if a record date is set).
     If the Reorganization Event is not determined to be a Liquidity Event,
     Optionee shall thereafter be entitled upon exercise of the Option to
     purchase the kind and number of shares of stock or other securities or
     property of the surviving corporation receivable upon such event by a
     holder of the number of shares of the Common Stock which the Option
     entitles Optionee to purchase from the Company immediately prior to such
     event, and in any such case, appropriate adjustment shall be made in the
     application of the provisions set forth in this Option Agreement with
     respect to Optionee's rights and interests thereafter, to the end that the
     provisions set forth in this Option Agreement (including the specified
     changes and other adjustments to the Exercise Price) shall thereafter be
     applicable in relation to any shares or other property thereafter
     purchasable upon exercise of the Option.

          (d) In the event of the proposed dissolution or liquidation of the
     Company, or in the event of any corporate separation or division,
     including, but not limited to, a split-up, split-off or spin-off (each, a
     "Liquidating Event"), the holder of any Stock Option then exercisable shall
     have the right to exercise such Stock Option (at the price provided in the
     Stock Option Agreement) subsequent to the Liquidating Event, and for the
     balance of its term, solely for the kind and amount of shares of Stock and
     other securities, property, cash or any combination thereof receivable upon
     such Liquidating Event by a holder of the number of shares of Stock for or
     with respect to which such Stock Option might have been exercised
     immediately prior to such Liquidating Event; or, in the alternative, that
     each Stock Option granted shall terminate as of a date to be fixed by the
     Board (or a committee thereof); provided, however, that not less than 30
     days written notice of the date so fixed shall be given to each Option
     Holder and if such notice is given, each Option Holder shall have the
     right, during the period of 30 days preceding such termination, to exercise
     the Stock Option as to all or any part of the shares of Stock covered
     thereby, without regard to installment or vesting provisions in Section 3
     of this Option Agreement, on the condition, however, that the Liquidating
     Event actually occurs; and if the Liquidating Event actually occurs, such
     exercise shall be deemed effective (and, if applicable, the Option Holder
     shall be deemed a shareholder with respect to the Stock Options exercised)
     immediately preceding the occurrence of the Liquidating Event, or the date
     of record for shareholders entitled to share in such Liquidating Event, if
     a record date is set.

          (e) To the extent that the foregoing adjustments relate to stock or
     securities of the Company, such adjustments shall be made by the Board (or
     a committee thereof), and their determination shall be final, binding and
     conclusive.


                                  EX-10-7 - 8
<PAGE>


          (f) The provisions of this Paragraph 7 are intended to be exclusive,
     and Optionee shall have no other rights upon the occurrence of any of the
     events described in this Paragraph 7.

          (g) The grant of the Option shall not affect in any way the right or
     power of the Company to make adjustments, reclassifications,
     reorganizations or changes

     8. Waiver of Rights to Purchase Stock.

     By signing this Option Agreement, Optionee acknowledges and agrees that
neither the Company nor any other person or entity is' under any obligation to
sell or transfer to Optionee any option or equity security of the Company, other
than the shares of Common Stock subject to the Option and any other fight or
option to purchase Common Stock which was previously granted to Optionee by the
Board (or a committee thereof). By signing this Option Agreement, Optionee
specifically waives all rights which he may have had prior to the date of this
Option Agreement to receive any option or equity security of the Company.

     9. Investment Intent.

     Optionee represents and agrees that if he exercises the Option in whole or
in part and if at the time of such exercise the Purchased Shares have not been
registered under the Act, he will acquire the Shares upon such exercise for the
purpose of investment and not with a view to the distribution of such Shares,
and that upon each exercise of the Option he will furnish to the Company a
written statement to such effect, if so requested by the Company.

     10. Legend on Stock Certificates.

     Optionee agrees that all certificates representing the Purchased Shares
will be subject to such stock transfer orders and other restrictions (if any) as
the Company may deem advisable under the rules, regulations and other
requirements of the Securities and Exchange Commission, any stock exchange upon
which the Common Stock is then listed and any applicable federal or state
securities laws, and the Company may cause a legend or legends to be put on such
certificates to make appropriate reference to such restrictions.

     11. No Rights as Shareholder.

     Optionee shall have no rights as a shareholder with respect to the Shares
until the date of the issuance to Optionee of a stock certificate or stock
certificates evidencing such Shares. Except as may be provided in Paragraph 7 of
this Option Agreement, no adjustment shall be made for dividends (ordinary or
extraordinary, whether in cash, securities or other property) or distributions
or other fights for which the record date is prior to the date such stock
certificate is issued.


                                  EX-10-7 - 9
<PAGE>


     12. Modification.

     The Board (or a committee thereof) may modify, extend or renew the Option
or accept the surrender of, and authorize the grant of a new option in
substitution for, the Option (to the extent not previously exercised).

     13. Withholding.

          (a) The Company shall be entitled to require as a condition of
     delivery of any Purchased Shares upon exercise of any Option that the
     Optionee agree to remit, at the time of such delivery or at such later date
     as the Company may determine, an amount sufficient to satisfy all federal,
     state and local withholding tax requirements relating thereto, and Optionee
     agrees to take such other action required by the Company to satisfy such
     withholding requirements.

          (b) With the consent of the Board (or a committee thereof), and in
     accordance with any rules and procedures from time to time adopted by the
     Board (or a committee thereof), Optionee may elect to satisfy his or her
     obligations under Paragraph 13(a) above by (i) directing the Company to
     withhold a portion of the Shares otherwise deliverable (or to tender back
     to the Company a portion of the Shares issued where the Optionee (a
     "Section 16(b) Recipient") is required to report the ownership of the
     Shares pursuant to Section 16(a) of the Securities Exchange Act of 1934, as
     amended, and has not made an election under Section 83(b) of the Code (a
     "Withholding Right")); or (ii) tendering other shares of the Common Stock
     of the Company which are already owned by Optionee which in all cases have
     a fair market value (as determined in accordance with the provisions of
     Paragraph 4(b) hereof) on the date as of which the amount of tax to be
     withheld is determined (the "Tax Date") equal to the amount of taxes to be
     paid by such method.

          (c) To exercise a Withholding Right, the Optionee must follow the
     election procedures set forth below, together with such additional
     procedures and conditions set forth in this Option Agreement or otherwise
     adopted by the Board (or a committee thereof):

               (i) the Optionee must deliver to the Company his or her written
          notice of election (the "Election") and specify whether all or a
          stated percentage of the applicable taxes will be paid in accordance
          with Paragraph 13(b) above and whether the amount so paid shall be
          made in accordance with the "fiat" withholding rates for supplemental
          wages or as determined in accordance with Optionee's form W-4 (or
          comparable state or local form);

               (ii) unless disapproved by the Board (or a committee thereof) or
          as provided in Subsection (iii) below, the Election once made will be
          irrevocable; and


                                  EX-10-7 - 10
<PAGE>


               (iii) no Election is valid unless the Board (or a committee
          thereof) consents to the Election; the Board (or a committee thereof)
          has the right and power, in its sole discretion, with or without cause
          or reason therefor, to consent to the Election, to refuse to consent
          to the Election, or to disapprove the Election; and if the Board (or a
          committee thereof) has not consented to the Election on or prior to
          the Tax Date, the Election will be deemed approved.

               (iv) If the Optionee on the date of delivery of the Election to
          the Company is a Section 16(b) Recipient, the following additional
          provisions will apply:

                    (a) the Election cannot be made during the six calendar
               month period commencing with the date of grant of the Withholding
               Right (even if the Option to which such Withholding Right relates
               has been granted prior to such date); and

                    (b) the Election must be made on a date which is six
               calendar months or more prior to the Tax Date.

     14. Character of Option.

     The Option is not intended to qualify as an "incentive stock option" as
that term is defined in Section 422 of the Code.

     15. General Provisions.

          (a) Further Assurances. Optionee shall promptly take all actions and
     execute all documents requested by the Company which the Company deems to
     be reasonably necessary to effectuate the terms and intent of this Option
     Agreement.

          (b) Notices. All notices, requests, demands and other communications
     under this Option Agreement shall be in writing and shall be given to the
     parties hereto as follows:

          If to the Company, to:

                   BIOSOURCE INTERNATIONAL, INC.
                   820 Flynn Road
                   Camarillo, California 93012

          If to Optionee, to the address set forth in the records of the
     Company,

or at such other address or addresses as may have been furnished by such either
party, in writing to the other party hereto. Any such notice, request, demand or
other communication


                                  EX-10-7 - 11
<PAGE>


shall be effective (i) if given by mail. 72 hours after such communication is
deposited in the mail by first-class certified mail, return receipt requested,
postage prepaid, addressed as aforesaid, or (ii) if given by any other means,
when delivered at the address specified in this subparagraph (b).

          (c) Transfer of Rights under this Option Agreement. The Company may at
     any time .transfer and assign its rights and delegate its obligations under
     this Option Agreement to any other person, corporation, firm or entity,
     including its officers, directors and stockholders, with or without
     consideration.

          (d) Option Non-Transferable. Optionee may not sell, transfer, assign
     or otherwise dispose of the Option except by will or the laws of descent
     and distribution and Stock Options may be exercised during the lifetime of
     the Option Holder only by the Option Holder or by his or her guardian or
     legal representative.

          (e) Successors and Assigns. Except to the extent specifically limited
     by the terms and provisions of this Option Agreement, this Option Agreement
     shall be binding upon and inure to the benefit of the parties hereto and
     their respective successors, assigns, heirs and personal representatives.

          (f) Governing Law. THIS OPTION AGREEMENT SHALL BE GOVERNED BY AND
     CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE LAWS OF THE STATE OF
     CALIFORNIA APPLICABLE TO CONTRACTS MADE IN, AND TO BE PERFORMED WITHIN,
     THAT STATE.

          (g) Miscellaneous. Titles and captions contained in this Option
     Agreement are inserted for convenience of reference only and do not
     constitute a part of this Option Agreement for any other purpose. Except as
     specifically provided herein, neither this Option Agreement nor any right
     pursuant hereto or interest herein shall be assignable by any of the
     parties hereto without the prior written consent of the other party hereto.

                  The Signature Page to this Option Agreement
                 consists of the last page of the Certificate.


                                  EX-10-7 - 12
<PAGE>


                                   Exhibit "A"

                               NOTICE OF EXERCISE

                 (To be signed only upon exercise of the Option)

TO: BioSource International, Inc.

     The undersigned, the holder of the enclosed Stock Option Agreement (Nora
Statutory Stock Option), hereby irrevocably elects to exercise the purchase
rights represented by the Option and to purchase thereunder __________________ *
shares of Common Stock of BioSource International, Inc. (the "Company"), and
herewith encloses payment of $_______ and/or _______ shares of the Company's
Common Stock in full payment of the purchase price of such shares being
purchased.

Dated: ________________________

                                             --------------------------------
                                              (Signature must conform in all
                                              respects to name of holder as
                                            specified on the face of the Option)



                                             -----------------------------------
                                             (Please Print Name)



                                             -----------------------------------
                                             (Address)


                                  EX-10-7 - 13
<PAGE>


     * Insert here the number of shares called for on the face of the Option
(or, in the case of a partial exercise, the number of shares being exercised),
in either case without making any adjustment for additional Common Stock of the
Company, other securities or property which, pursuant to the adjustment
provisions of the Option, may be deliverable upon exercise.


                                  EX-10-7 - 14

Exhibit 10.8


                               OPTION CERTIFICATE
                          (NON-STATUTORY STOCK OPTION)

     THIS IS TO CERTIFY that BioSource International, Inc., a Delaware
corporation (the "Company"), has granted to the person named below a
non-statutory stock option (the "Option") to purchase shares of the Company's
Common Stock, par value $0.001 per share (the "Shares"), as follows:

Name of Optionee:       Jordan B. Fishman, Ph.D.

Address of Optionee:    29 Lynbrook Road
                        Southborough, Massachusetts 01772

Number of Shares:       100,000

Option Exercise Price:  $2 13/16

Option Expiration Date: December 8, 2008

     EXERCISE SCHEDULE: The Option shall become exercisable as follows: the
option to purchase 33,333 shares vests on December 9, 1999, the option to
purchase an additional 33,333 shares vests on December 9, 2000 and the option to
purchase an additional 33,334 shares vests on December 9, 2001 (the "Vesting
Date").

     SUMMARY OF OTHER TERMS: This Option is defined in the Stock Option
Agreement (Non-Statutory Stock Option) (the "Option Agreement") which is
attached to this Option Certificate (the "Certificate") as Annex I. This
Certificate summarizes certain of the provisions of the Option Agreement for
your information, but is not complete. Your rights are governed by the Option
Agreement, not by this Summary. The Company strongly suggests that you carefully
review the full Option Agreement prior to signing this Certificate or exercising
the Option.

     Among the terms of the Option Agreement are the following:

     EMPLOYMENT: Unless otherwise provided in your Executive Employment
Agreement with the Company, dated as of December 9, 1998 ("Employment
Agreement"), the Option Agreement obligates you to work for the Company (or hold
office if you are a director) for one (1) year from the Date of Grant of the
Option. Note, however, that should you fail to do so, the Company's sole remedy
is to cancel the portion of your Option which is not then


<PAGE>


exercisable (unless otherwise provided in your Employment Agreement). The Option
Agreement does not obligate the Company to retain you for one (1) year. See
Paragraph 3 and the Exercise Schedule, above. Unless otherwise agreed in
writing, the Company reserves the right to terminate any employee at any time,
with or without cause.

     TERMINATION OF EMPLOYMENT: Unless otherwise provided in your Employment
Agreement, while the Option terminates on the Option Expiration Date, it will
terminate earlier if you cease to be employed by the Company (or hold office if
you are a director). If your employment is terminated "for cause" (as defined in
your Employment Agreement), the Option terminates 30 days after the date of
termination of employment, and is exercisable during such 30 day period as to
the portion of the Option which had vested prior to the date of termination of
employment. If your employment is terminated due to death or permanent
disability, the Option terminates one year after the date of death or
disability, and is exercisable during such one year period as to the portion of
the Option which had vested prior to the date of death or disability. Unless
otherwise provided in your Employment Agreement, in all other cases, the Option
terminates 90 days after the date of termination of employment, and is
exercisable during such 90 day period as to the portion of the Option which had
vested prior to the date of termination of employment. See Paragraph 5.

     TRANSFER: The Option is personal to you, and cannot be sold, transferred,
assigned or otherwise disposed of to any other person, except on your death. See
Paragraph 15(d).

     EXERCISE: You can exercise the Option (once it is exercisable), in whole or
in part, by delivering to the Company a Notice of Exercise identical to Exhibit
"A" attached to the Option Agreement, accompanied by payment of the Exercise
Price for the Shares to be purchased. The Company will then issue a certificate
to you for the Shares you have purchased. You are under no obligation to
exercise the Option. See Paragraph 4.

     ANTI-DILUTION PROVISIONS: The Option contains provisions which adjust your
Option to reflect stock splits, stock dividends, mergers and other major
corporate reorganizations which would change the nature of the Shares underlying
your Option. See Paragraph 7.

     WAIVER: By signing this Certificate, you will be agreeing to all of the
terms of the Option Agreement, including those not summarized in this
Certificate. You will waive your rights to options or stock which may have been
promised to you. See Paragraph 8.

     WITHHOLDING: The Company may require you to make any arrangements necessary
to insure the proper withholding of any amount of tax, if any, required to be
withheld by the Company as a result of the exercise of the Option. See Paragraph
13.


                                  EX-10-8 - 2
<PAGE>


                                    AGREEMENT

     BioSource International, Inc., a Delaware corporation (the "Company"), and
the above-named person (the "Optionee") each hereby agrees to be bound by all of
the terms and conditions of the Stock Option Agreement (Incentive Stock Option)
which is attached hereto as Annex I and incorporated herein by this reference if
set forth in full in this document.

DATED: December 9, 1998

                                       BIOSOURCE INTERNATIONAL, INC.


                                       BY:   /S/ JAMES CHAMBERLAIN
                                             -----------------------------------
                                             Its:  President & Chief Executive
                                                   Officer


                                       BY:  /S/ JORDAN S. FISHMAN
                                             -----------------------------------
                                             Employee Signature

                                              -------------------------------
                                              (Please print your name exactly
                                              as you wish it to appear on any
                                             stock certificates issued to you
                                               upon exercise of the Option)


                                  EX-10-8 - 3
<PAGE>


                                     ANNEX I

                             STOCK OPTION AGREEMENT
                          (Non-Statutory Stock Option)

     This STOCK OPTION AGREEMENT (this "Option Agreement") is made and entered
into on the execution date of the Option Certificate to which it is attached
(the "Certificate"), by and between BioSource International, Inc., a Delaware
corporation (the "Company"), and the person named in the Certificate
("Optionee").

     The Board of Directors of the Company (the "Board") has authorized the
grant to Optionee of a non-statutory stock option to purchase shares of the
Company's Common Stock, par value $0.001 per share (the "Common Stock"), upon
the terms and subject to the conditions set forth in this Option Agreement.

     The Company and Optionee agree as follows:

     1. Grant of Option.

          The Company hereby grants to Optionee the right and option (the
     "Option"), upon the terms and subject to the conditions set forth in this
     Option Agreement, to purchase all or any portion of that number of shares
     of the Common Stock (the "Shares") set forth in the Certificate, at the
     Option exercise price set forth in the Certificate (the "Exercise Price").

     2. Term of Option.

     The Option shall terminate and expire on the Option Expiration Date set
forth in the Certificate, unless sooner terminated as provided herein.

     3. Exercise Period.

          (a) Subject to the provisions of Paragraphs 3(b), 5, 7(c) and 7(d) of
     this Option Agreement and except as otherwise provided in your Executive
     Employment Agreement with the Company (the "Employment Agreement"), the
     Option shall become exercisable (in whole or in part) upon and after the
     dates set forth under the caption "Exercise Schedule" in the Certificate.
     The installments shall be cumulative; i.e., the Option may be exercised, as
     to any or all Shares covered by an installment, at any time or times after
     the installment first becomes exercisable and until expiration or
     termination of the Option.


                                  EX-10-8 - 4
<PAGE>


          (b) Notwithstanding anything to the contrary contained in this Option
     Agreement, the Option may not be exercised, in whole or in part, unless and
     until any then-applicable requirements of all federal, state and local laws
     and regulatory agencies shall have been fully complied with to the
     satisfaction of the Company and its counsel.

     4. Exercise of Option.

          There is no obligation to exercise the Option, in whole or in part.
     The Option may be exercised, in whole or in part, only by delivery to the
     Company of:

          (a) written notice of exercise in form and substance identical to
     Exhibit "A" attached to this Option Agreement stating the number of shares
     of Common Stock then being purchased (the "Purchased Shares"); and

          (b) payment of the Exercise Price of the Purchased Shares, either in
     cash, by check, by cancellation of any indebtedness of the Company to
     Optionee for accrued and unpaid salary or, with the consent of the Board
     (or a committee thereof), by transfer to the Company of issued and
     outstanding shares of Common Stock which have been held by Optionee for a
     period of at least six calendar months preceding the date of surrender and
     which have a fair market value equal to the exercise price, or by any
     combination of the above methods of payment. If payment is made, in whole
     or in part, by transfer to the Company of issued and outstanding shares of
     Common Stock, the value of such shares shall be determined as follows: (i)
     if the Stock is listed on an exchange or exchanges, or admitted for trading
     in a market system which provides last sale data under Rule l lAa3-1 of the
     General Rules and Regulations of the Securities and Exchange Commission
     under the Securities and Exchange Act of 1934, as amended (a "Market
     System"), the last reported sales price per share on the last business day
     prior to such date on the principal exchange on which it is traded, or in
     such a Market System, as applicable, or if no sale was made on such day on
     such principal exchange or in such a Market System, as applicable, the last
     reported sales price per share on the most recent day prior to such date on
     which a sale was reported on such exchange or such Market System, as
     applicable; or (ii) if the Common Stock is not then traded on an exchange
     or in such a Market System, the average of the closing bid and asked prices
     per share for the Common Stock in the over-the-counter market as quoted on
     NASDAQ on the day prior to such date; or (iii) if the Common Stock is not
     listed on an exchange or quoted on NASDAQ, an amount determined in good
     faith by the Board (or a committee thereof).

     Following receipt of the notice and payment referred to above, the Company
shall issue and deliver to Optionee a stock certificate or stock certificates
evidencing the


                                  EX-10-8 - 5
<PAGE>


Purchased Shares; provided, however, that the Company shall not be obligated to
issue a fraction or fractions of a share of its Common Stock, and may pay to
Optionee, in cash or by check, the fair market value of any fraction or
fractions of a share exercised by Optionee, which fair market value shall be
determined as set forth in the preceding paragraph.

     5.   Termination of Employment.

          (a) Unless otherwise provided in your Employment Agreement, if
     Optionee shall cease to be a Director of the Company, or to be in the
     employ of, or a consultant to the Company, any Subsidiary or any Parent for
     any reason other than Optionee's death, permanent disability, or
     retirement, Optionee shall have the right to exercise the Option at any
     time within 90 days after the date Optionee ceased to be a Director of the
     Company, or to be employed by, or to be a consultant to the Company, and
     prior to the date of termination of the Option under Paragraph 2 of this
     Option Agreement with respect to all shares with respect to which the
     Option was exercisable at the date Optionee's employment terminated as to
     which the Option had not previously been exercised; and, unless otherwise
     provided in your Employment Agreement, to the extent unexercised at the end
     of this period, the Option shall terminate. Unless otherwise provided in
     your Employment Agreement, the Board (or a committee thereof), in its sole
     and absolute discretion, shall determine whether or not authorized leaves
     of absence shall constitute termination of employment for purposes of this
     Option Agreement.

          (b) If Optionee shall be terminated "for cause" by the Company, any
     Subsidiary or any Parent, Optionee shall have the right to exercise the
     Option at any time within 30 days after such termination of employment and
     prior to the date of termination of the Option under Paragraph 2 of this
     Option Agreement with respect to all Shares with respect to which the
     Option was exercisable on the effective date his employment terminated as
     to which the Option had not previously been exercised.

          (c) Unless otherwise provided in your Employment Agreement, if
     Optionee shall cease to be a Director of the Company, or to be in the
     employ of, or a consultant to the Company, any Subsidiary or any Parent by
     reason of Optionee's death, permanent disability, or retirement (a "Special
     Terminating Event"), then Optionee, Optionee's executors or administrators
     or any person or persons acquiring the Option directly from Optionee by
     bequest or inheritance, shall have the right to exercise the Option with
     respect to all Shares granted under the Option at any time within one year
     after such Special Terminating Event; to the extent the Option is
     unexercised at the end of that period, the Option will terminate.


                                  EX-10-8 - 6
<PAGE>


          (d) For purposes of this Option Agreement, unless otherwise defined in
     your Employment Agreement, a termination "for cause" shall mean termination
     by the Company by reason of:

               (1) with respect to employees of the Company:

                    (i) the failure or refusal by Optionee to perform his duties
               to the Company; or

                    (ii) Optionee's willful disobedience of any orders or
               directives of the Board or any officers thereof acting under the
               authority thereof or Optionee's deliberate interference with the
               compliance by other employees of the Company with any such orders
               or directives; or

                    (iii) the failure or refusal of Optionee to abide by or
               comply with the written policies, standard procedures or
               regulations of the Company; or

                    (iv) any willful or continued act or course of conduct by
               Optionee which the Board in good faith determines might
               reasonably be expected to have a material detrimental effect on
               the Company or the business, operations, affairs or financial
               position thereof; or

                    (v) the committing by the Optionee of any fraud, theft,
               embezzlement or other dishonest act against the Company; or

                    (vi) the determination by the Board, in good faith and in
               the exercise of reasonable discretion, that Optionee is not
               competent to perform his duties of employment; and

               (2) with respect to consultants, any material breach of their
          consulting agreement with the Company.

          (e) For purposes of this Option Agreement, "permanent disability"
     shall have the meaning set forth in Section 2(a)(iii) of your Employment
     Agreement.

     6. Restrictions on Purchased Shares.

          None of the Purchased Shares shall be transferred (with or without
     consideration), sold, offered for sale, assigned, pledged, hypothecated or
     otherwise disposed of (each a "Transfer") and the Company shall not be
     required to register any such Transfer and the Company may instruct its
     transfer agent not to register any such Transfer, unless and until all of
     the following events shall have occurred:


                                  EX-10-8 - 7
<PAGE>


          (a) the Purchased Shares are Transferred pursuant to and in conformity
     with (i) (x) an effective registration statement filed with the Securities
     and Exchange Commission (the "Commission") pursuant to the Securities Act
     of 1933, as amended (the "Act"), or (y) an exemption from registration
     under the Act; and (ii) the securities laws of any state of the United
     States; and

          (b) Optionee has, prior to the Transfer of such Purchased Shares,
     provided all relevant information to Company's counsel so that upon
     Company's request, Company's counsel is able to, and actually prepares and
     delivers to the Company a written opinion that the proposed Transfer (i)
     (x) is pursuant to a registration statement which has been filed with the
     Commission and is then effective, or (y) is exempt from registration under
     the Act as then in effect, and the Rules and Regulations of the Commission
     thereunder; and (ii) is either qualified or registered under any applicable
     state securities laws, or exempt from such qualification or registration.
     The Company shall bear all reasonable costs of preparing such opinion.

          Any attempted Transfer which is not in full compliance with this
     Paragraph 6 shall be null and void ab initio, and of no force or effect.

     7. Adjustments upon Recapitalization.

          Subject to any required action by the shareholders of the Company:

          (a) If the outstanding shares of the Common Stock shall be subdivided
     into a greater number of shares of the Common Stock, or a dividend in
     shares of Common Stock or other securities of the Company convertible into
     or exchangeable for shares of the Common Stock (in which latter event the
     number of shares of Common Stock issuable upon the conversion or exchange
     of such securities shall be deemed to have been distributed) shall be paid
     in respect of the shares of Common Stock, the Exercise Price in effect
     immediately prior to such subdivision or at the record date of such
     dividend shall, simultaneously with the effectiveness of such subdivision
     or immediately after the record date of such dividend, be proportionately
     reduced, and conversely, if the outstanding shares of Common Stock shall be
     combined into a smaller number of shares of Common Stock, the Exercise
     Price in effect immediately prior to such combination shall, simultaneously
     with the effectiveness of such combination, be proportionately increased.

          (b) When any adjustment is required to be made in the Exercise Price,
     the number of Shares purchasable upon the exercise of the Option shall be
     adjusted to that number of Shares determined by (i) multiplying an amount
     equal to the number of Shares purchasable on the exercise of the Option
     immediately prior to such adjustment by the Exercise Price in effect
     immediately prior to such adjustment,


                                  EX-10-8 - 8
<PAGE>


     and then (ii) dividing that product by the Exercise Price in effect
     immediately after such adjustment.

          (c) In case of any capital reorganization, any reclassification of the
     Common Stock (other than a change in par value or recapitalization
     described in Paragraph 7(a) of this Option Agreement), or the consolidation
     of the Company with, or a sale of substantially all of the assets of the
     Company to (which sale is followed by a liquidation or dissolution of the
     Company), or merger of the Company with another person (a "Reorganization
     Event"), the Board (or a committee thereof) shall be obligated to determine
     whether the Reorganization Event shall constitute a "Liquidity Event," and
     to deliver to Optionee at least 15 days prior to such Reorganization Event
     a notice which shall (i) indicate whether the Reorganization Event is a
     Liquidity Event; (ii) indicate whether the Liquidity Event shall result in
     the acceleration of the vesting provisions of this Option; and (iii) advise
     Optionee of his or her fights pursuant to this Option Agreement. If the
     Reorganization Event is determined to be a Liquidity Event, in its sole and
     absolute discretion, the surviving corporation may, but shall not be
     obligated to, (i) tender to Optionee Stock Options with respect to the
     surviving corporation which shall contain terms and provisions that
     substantially preserve the rights and benefits of this Option, and (ii) in
     the event that no Stock Options have been tendered by the surviving
     corporation pursuant to the terms of item (i) immediately above, Optionee
     shall have the right exercisable during a ten-day period ending on the
     fifth day prior to the Reorganization Event (or ending on the fifth day
     prior to the date of record for shareholders entitled to share in the
     securities or property distributed in the Reorganization Event, if a record
     date is set) to exercise his or her Stock Options in whole or in part, and
     if so determined by the Board (or a committee thereof), without regard to
     any installment provisions under his or her Stock Option Agreement, on the
     condition, however, that the Reorganization Event is actually effected; and
     if the Reorganization Event is actually effected, such exercise shall be
     deemed effective (and, if applicable, the Optionee shall be deemed a
     shareholder with respect to the Stock Options exercised) immediately
     preceding the effective time of the Reorganization Event (or on the date of
     record for shareholders entitled to share in the securities or property
     distributed in the Reorganization Event, if a record date is set). If the
     Reorganization Event is not determined to be a Liquidity Event, Optionee
     shall thereafter be entitled upon exercise of the Option to purchase the
     kind and number of shares of stock or other securities or property of the
     surviving corporation receivable upon such event by a holder of the number
     of shares of the Common Stock which the Option entitles Optionee to
     purchase from the Company immediately prior to such event, and in any such
     case, appropriate adjustment shall be made in the application of the
     provisions set forth in this Option Agreement with respect to Optionee's
     rights and interests


                                  EX-10-8 - 9
<PAGE>


     thereafter, to the end that the provisions set forth in this Option
     Agreement (including the specified changes and other adjustments to the
     Exercise Price) shall thereafter be applicable in relation to any shares or
     other property thereafter purchasable upon exercise of the Option.

          (d) In the event of the proposed dissolution or liquidation of the
     Company, or in the event of any corporate separation or division,
     including, but not limited to, a split-up, split-off or spin-off (each, a
     "Liquidating Event"), the holder of any Stock Option then exercisable shall
     have the right to exercise such Stock Option (at the price provided in the
     Stock Option Agreement) subsequent to the Liquidating Event, and for the
     balance of its term, solely for the kind and amount of shares of Stock and
     other securities, property, cash or any combination thereof receivable upon
     such Liquidating Event by a holder of the number of shares of Stock for or
     with respect to which such Stock Option might have been exercised
     immediately prior to such Liquidating Event; or, in the alternative, that
     each Stock Option granted shall terminate as of a date to be fixed by the
     Board (or a committee thereof); provided, however, that not less than 30
     days written notice of the date so fixed shall be given to each Option
     Holder and if such notice is given, each Option Holder shall have the
     right, during the period of 30 days preceding such termination, to exercise
     the Stock Option as to all or any part of the shares of Stock covered
     thereby, without regard to installment or vesting provisions in Section 3
     of this Option Agreement, on the condition, however, that the Liquidating
     Event actually occurs; and if the Liquidating Event actually occurs, such
     exercise shall be deemed effective (and, if applicable, the Option Holder
     shall be deemed a shareholder with respect to the Stock Options exercised)
     immediately preceding the occurrence of the Liquidating Event, or the date
     of record for shareholders entitled to share in such Liquidating Event, if
     a record date is set.

          (e) To the extent that the foregoing adjustments relate to stock or
     securities of the Company, such adjustments shall be made by the Board (or
     a committee thereof), and their determination shall be final, binding and
     conclusive.

          (f) The provisions of this Paragraph 7 are intended to be exclusive,
     and Optionee shall have no other fights upon the occurrence of any of the
     events described in this Paragraph 7.

          (g) The grant of the Option shall not affect in any way the fight or
     power of the Company to make adjustments, reclassifications,
     reorganizations or changes in its capital or business structure, or to
     merge, consolidate, dissolve or liquidate, or to sell or transfer all or
     any part of its business or assets.


                                  EX-10-8 - 10
<PAGE>


     8. Waiver of Rights to Purchase Stock.

     By signing this Option Agreement, Optionee acknowledges and agrees that
neither the Company nor any other person or entity is under any obligation to
sell or transfer to Optionee any option or equity security of the Company, other
than the shares of Common Stock subject to the Option and any other fight or
option to purchase Common Stock which was previously granted to Optionee by the
Board (or a committee thereof). By signing this Option Agreement, Optionee
specifically waives all fights which he may have had prior to the date of this
Option Agreement to receive any option or equity security of the Company.

     9. Investment Intent.

     Optionee represents and agrees that if he exercises the Option in whole or
in part and if at the time of such exercise the Purchased Shares have not been
registered under the Act, he will acquire the Shares upon such exercise for the
purpose of investment and not with a view to the distribution of such Shares,
and that upon each exercise of the Option he will furnish to the Company a
written statement to such effect, if so requested by the Company.

     10. Legend on Stock Certificates.

     Optionee agrees that all certificates representing the Purchased Shares
will be subject to such stock transfer orders and other restrictions (if any) as
the Company may deem advisable under the rules, regulations and other
requirements of the Securities and Exchange Commission, any stock exchange upon
which the `Common Stock is then listed and any applicable federal or state
securities laws, and the Company may cause a legend or legends to be put on such
certificates to make appropriate reference to such restrictions.

     11. No Rights as Shareholder.

     Optionee shall have no rights as a shareholder with respect to the Shares
until the date of the issuance to Optionee of a stock certificate or stock
certificates evidencing such Shares. Except as may be provided in Paragraph 7 of
this Option Agreement, no adjustment shall be made for dividends (ordinary or
extraordinary, whether in cash, securities or other property) or distributions
or other rights for which the record date is prior to the date such stock
certificate is issued.

     12. Modification.

     The Board (or a committee thereof) may modify, extend or renew the Option
or accept the surrender of, and authorize the grant of a new option in
substitution for, the


                                  EX-10-8 - 11
<PAGE>


Option (to the extent not previously exercised).

     13. Withholding.

          (a) The Company shall be entitled to require as a condition of
     delivery of any Purchased Shares upon exercise of any Option that the
     Optionee agree to remit, at the time of such delivery or at such later date
     as the Company may determine, an amount sufficient to satisfy all federal,
     state and local withholding tax requirements relating thereto, and Optionee
     agrees to take such other action required by the Company to satisfy such
     withholding requirements.

          (b) With the consent of the Board (or a committee thereof), and in
     accordance with any rules and procedures from time to time adopted by the
     Board (or a committee thereof), Optionee may elect to satisfy his or her
     obligations under Paragraph 13(a) above by (i) directing the Company to
     withhold a portion of the Shares otherwise deliverable (or to tender back
     to the Company a portion of the Shares issued where the Optionee (a
     "Section 16(b) Recipient") is required to report the ownership of the
     Shares pursuant to Section 16(a) of the Securities Exchange Act of 1934, as
     amended, and has not made an election under Section 83(b) of the Code (a
     "Withholding Right")); or (ii) tendering other shares of the Common Stock
     of the Company which are already owned by Optionee which in all cases have
     a fair market value (as determined in accordance with the provisions of
     Paragraph 4(b) hereof) on the date as of which the amount of tax to be
     withheld is determined (the "Tax Date") equal to the amount of taxes to be
     paid by such method.

          (c) To exercise a Withholding Right, the Optionee must follow the
     election procedures set forth below, together with such additional
     procedures and conditions set forth in this Option Agreement or otherwise
     adopted by the Board (or a committee thereof):

               (i) the Optionee must deliver to the Company his or her written
          notice of election (the "Election") and specify whether all or a
          stated percentage of the applicable taxes will be paid in accordance
          with Paragraph 13(b) above and whether the amount so paid shall be
          made in accordance with the "flat" withholding rates for supplemental
          wages or as determined in accordance with Optionee's form W-4 (or
          comparable state or local form);

               (ii) unless disapproved by the Board (or a committee thereof) or
          as provided in Subsection (iii) below, the Election once made will be
          irrevocable; and


                                  EX-10-8 - 12
<PAGE>


               (iii) no Election is valid unless the Board (or a committee
          thereof) consents to the Election; the Board (or a committee thereof)
          has the right and power, in its sole discretion, with or without cause
          or reason therefor, to consent to the Election, to refuse to consent
          to the Election, or to disapprove the Election; and if the Board (or a
          committee thereof) has not consented to the Election on or prior to
          the Tax Date, the Election will be deemed approved.

               (iv) If the Optionee on the date of delivery of the Election to
          the Company is a Section 16(b) Recipient, the following additional
          provisions will apply:

                    (a) the Election cannot be made during the six calendar
               month period commencing with the date of ant of the Withholding
               Right (even if the Option to which such Withholding Right relates
               has been granted prior to such date); and

                    (b) the Election must be made on a date which is six
               calendar months or more prior to the Tax Date.

     14. Character of Option.

          The Option is not intended to qualify as an "incentive stock option"as
     that term is defined in Section 422 of the Code.

     15. General Provisions.

          (a) Further Assurances. Optionee shall promptly take all actions and
     execute all documents requested by the Company which the Company deems to
     be reasonably necessary to effectuate the terms and intent of this Option
     Agreement.

          (b) Notices. All notices, requests, demands and other communications
     under this Option Agreement shall be in writing and shall be given to the
     parties hereto as follows:

          If to the Company, to:

               BioSource International, Inc.
               820 Flynn Road
               Camarillo, California 93012
               Attention: Secretary

          If to Optionee, to the address set forth in the records of the
     Company,


                                  EX-10-8 - 13
<PAGE>


or at such other address or addresses as may have been furnished by such either
party in writing to the other party hereto. Any such notice, request, demand or
other communication shall be effective (i) if given by mail, 72 hours after such
communication is deposited in the mail by first class certified mail, return
receipt requested, postage prepaid, addressed as aforesaid, or (ii) if given by
any other means, when delivered at the address specified in this subparagraph
(b).

          (c) Transfer of Rights under this Option Agreement. The Company may at
     any time transfer and assign its rights and delegate its obligations under
     this Option Agreement to any other person, corporation, firm or entity,
     including its officers, directors and stockholders, with or without
     consideration.

          (d) Option Non-Transferable. Optionee may not sell, transfer, assign
     or otherwise dispose of the Option except by will or the laws of descent
     and distribution and Stock Options may be exercised during the lifetime of
     the Option Holder only by the Option Holder or by his or her guardian or
     legal representative.

          (e) Successors and Assigns. Except to the extent specifically limited
     by the terms and provisions of this Option Agreement, this Option Agreement
     shall be binding upon and inure to the benefit of the parties hereto and
     their respective successors, assigns, heirs and personal representatives.

          (f) Governing Law. THIS OPTION AGREEMENT SHALL BE GOVERNED BY AND
     CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE LAWS OF THE STATE OF
     CALIFORNIA APPLICABLE TO CONTRACTS MADE IN, AND TO BE PERFORMED WITHIN,
     THAT STATE.

          (g) Miscellaneous. Titles and captions contained in this Option
     Agreement are inserted for convenience of reference only and do not
     constitute a part of this Option Agreement for any other purpose. Except as
     specifically provided herein, neither this Option Agreement nor any right
     pursuant hereto or interest herein shall be assignable by any of the
     parties hereto without the prior written consent of the other party hereto.

                   The Signature Page to this Option Agreement
                  consists of the last page of the Certificate.


                                  EX-10-8 - 14
<PAGE>


                                   Exhibit "A"

                               NOTICE OF EXERCISE

                 (To be signed only upon exercise of the Option)

TO: BioSource International, Inc.

     The undersigned, the holder of the enclosed Stock Option Agreement (Non
Statutory Stock Option), hereby irrevocably elects to exercise the purchase
fights represented by the Option and to purchase thereunder _______________*
shares of Common Stock of BioSource International, Inc. (the "Company"), and
herewith encloses payment of $_______________ and/or ______________shares of the
Company's Common Stock in full payment of the purchase price of such shares
being purchased.

Dated: ________________________

                                             --------------------------------
                                              (Signature must conform in all
                                              respects to name of holder as
                                            specified on the face of the Option)



                                             -----------------------------------
                                             (Please Print Name)



                                             -----------------------------------
                                             (Address)


                                  EX-10-8 - 15
<PAGE>


     * Insert here the number of shares called for on the face of the Option
(or, in the case of a partial exercise, the number of shares being exercised),
in either case without making any adjustment for additional Common Stock of the
Company, other securities or property which, pursuant to the adjustment
provisions of the Option, may be deliverable upon exercise.


                                  EX-10-8 - 16

Exhibit 10.9


                                 AMENDMENT NO. 1
                                       TO
                          BIOSOURCE INTERNATIONAL, INC.
                            1993 STOCK INCENTIVE PLAN

     This AMENDMENT NUMBER ONE to the 1993 Stock Incentive Plan (the "PLAN") of
BioSource International, Inc., a Delaware corporation (the "COMPANY"), is made
as of this 17th day of December, 1998.

                                 R E C I T A L S

     A. In December of 1993, the Company adopted the Plan for the purpose of
enabling the Company to obtain and retain the services of the types of
employees, consultants, officers and Directors who would contribute to the
Company's long range success and providing incentives which are linked directly
to increases in share value which would inure to the benefit of all shareholders
of the Company.

     B. Article 9 of the Plan requires that the stockholders of the Company
approve certain amendments to the Plan.

     C. Since the adoption of the Plan, and its approval by the stockholders of
the Company, there have been changes in Rule 16b-3 under the Securities Exchange
Act of 1934, and the regulations of the Nasdaq NMS eliminating the requirement
of stockholder approval for certain changes to the Plan.

     D. The Company now desires to amend the Plan as it relates to stockholder
approval to be consistent with the changes in the law and Nasdaq regulations,
and to increase the number of shares authorized to be issued thereunder.

                                A G R E E M E N T

     NOW THEREFORE, in furtherance of the above-stated purpose of the Plan, the
Plan is hereby amended as follows:

     1. Article 9 of the Plan is hereby amended. The text formerly in Article 9
is hereby stricken and eliminated, and Article 9 shall hereafter read as
follows:

                                    ARTICLE 9
                            AMENDMENT AND TERMINATION

     The Board may amend, alter or discontinue the Plan at any time, pursuant to
the discretion of the Board.


<PAGE>


     2. Section 4.1 of Article 4 of the Plan is hereby amended to increase the
total number of shares of Stock (as defined in the Plan) reserved and available
for issuance under the Plan to 2,000,000 shares of Stock (an increase of 500,000
Shares).


                                   EX-10-9 - 2

Exhibit 23.1


                         INDEPENDENT AUDITORS' CONSENT

The Board of Directors
BioSource International, Inc.:

We consent to the incorporation by reference in the Registration Statement on
Form S-8 of BioSource International, Inc. of our reports dated March 26, 1999,
with respect to the consolidated balance sheets of BioSource International, Inc.
and subsidiaries as of December 31, 1998 and 1997, and the related consolidated
statements of operations, stockholders' equity, and cash flows for each of the
years in the three year period ended December 31, 1998, and the related
schedule, which reports appear in the December 31, 1998 annual report on Form
10-K/A of BioSource International, Inc.



/S/ KPMG LLP



Los Angeles, California
February 17, 2000


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