REED CONNER & BIRDWELL INC
SC 13D, 2000-09-19
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<PAGE>

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13D

Under the Securities Exchange Act of 1934
(Amendment No. )

TRIPOS INC.
------------------------------------------------------------
(Name of Issuer)


Common Stock
------------------------------------------------------------
(Title of Class of Securities)


896928108
------------------------------------------------------------
(CUSIP NUMBER)


Jeffrey Bronchick, CIO
Reed, Conner & Birdwell, Inc.
11111 Santa Monica Boulevard, Suite 1700
Los Angeles, CA  90025
Tel No. (310) 478-4005
------------------------------------------------------------
(Name, Address and Telephone Number of Person
Authorized to Receive Notices and Communications)


                            September 18, 2000
------------------------------------------------------------
          (Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition that is the subject of this Schedule 13D, and is filing this
schedule because of Sections 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check
the following box. [X]

Note: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See Section 240.13d-7 for
other parties to whom copies are to be sent.

* The remainder of this coverage page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

The information required on the remainder of this coverage page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act")or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).

<PAGE>

CUSIP:  896928108

---------------------------------------------------------------
1  NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE
   PERSONS (ENTITIES ONLY)

   Reed Conner & Birdwell, Inc. I.R.S. Identification No. 95-2461281

---------------------------------------------------------------
2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                   (a)  [   ]
   N/A                                                   (b)  [   ]

---------------------------------------------------------------
3        SEC USE ONLY

---------------------------------------------------------------
4        SOURCE OF FUNDS

         00
---------------------------------------------------------------
5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
     PURSUANT TO ITEM 2(D) OR 2(E)                      [   ]

      N/A

---------------------------------------------------------------
6    CITIZENSHIP OR PLACE OR ORGANIZATION
p
     California

---------------------------------------------------------------
NUMBER OF         7        SOLE VOTING POWER                  0
SHARES            ---------------------------------------------
BENEFICIALLY      8        SHARED VOTING POWER          191,084
OWNED BY          ---------------------------------------------
EACH              9        SOLE DISPOSITIVE POWER             0
REPORTING         ---------------------------------------------
PERSON WITH       10       SHARED DISPOSITIVE POWER     191,084

---------------------------------------------------------------
11       AGGREGATE AMOUNT BENEFICALLY OWNED BY EACH REPORTING PERSON

         191,084

---------------------------------------------------------------
12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
      SHARES*                                              [    ]

---------------------------------------------------------------
13       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

         5.43%

<PAGE>



---------------------------------------------------------------
14       TYPE OF REPORTING PERSON

         IA

Cusip # 896928108
Item 1: Reporting Person - Donn B. Conner*
Item 4: OO
Item 6: USA
Item 7: 191,084
Item 8: None
Item 9: 191,084
Item 10: None
Item 11: 191,084
Item 13: 5.43%
Item 14: IN

Cusip # 896928108
Item 1: Reporting Person - Jeffrey Bronchick*
Item 4: OO
Item 6: USA
Item 7: 191,084
Item 8: None
Item 9: 191,084
Item 10: None
Item 11: 191,084
Item 13: 5.43%
Item 14 IN

Cusip # 896928108
Item 1: Reporting Person - James C. Reed*
Item 4: OO
Item 6: USA
Item 7: 191,084
Item 8: None
Item 9: 191,084
Item 10: None
Item 11: 191,084
Item 13: 5.43%
Item 14: IN

Cusip # 896928108
Item 1: Reporting Person - James P. Birdwell*
Item 4: OO
Item 6: USA
Item 7: 191,084
Item 8: None
Item 9: 191,084
Item 10: None
Item 11: 191,084
Item 13: 5.43%
Item 14: IN

<PAGE>

* Collectively referred to herein as "Control Persons"


Item 1.  Security and Issuer

The title of the class of equity security to which this statement relates is the
Common Stock of Tripos, Inc. whose principal executive offices are located at
1699 South Hanley Road, St. Louis, MO 63144.

Item 2.  Identity & Background

(a)      Reed Conner & Birdwell, Inc.
(b)      11111 Santa Monica Boulevard, Suite 1700, LA, CA  90025
(c)      Investment Adviser
(d)      N/A
(e)      N/A
(f)      U.S.A.

(a)      Donn B. Conner
(b)      11111 Santa Monica Boulevard, Suite 1700, LA, CA  90025
(c)      President & CEO of RCB
(d)      N/A
(e)      N/A
(f)      U.S.A.

(a)      Jeffrey Bronchick
(b)      11111 Santa Monica Boulevard, Suite 1700, LA, CA  90025
(c)      CIO of RCB
(d)      N/A
(e)      N/A
(f)      U.S.A.

(a)      James C. Reed
(b)      11111 Santa Monica Boulevard, Suite 1700, LA, CA  90025
(c)      Executive Vice President of RCB
(d)      N/A
(e)      N/A
(f)      U.S.A.

(a)      James P. Birdwell
(b)      11111 Santa Monica Boulevard, Suite 1700, LA, CA  90025
(c)      Executive Vice President of RCB
(d)      N/A
(e)      N/A
(f)      U.S.A.


Item 3.  Source and Amount of Funds or Other Consideration

Reed, Conner & Birdwell, Inc. in its capacity as an investment adviser will
purchase on behalf of its' clients. No monies are borrowed for such an
acquisition.


Item 4.  Purpose of Transaction

Reed, Conner & Birdwell, Inc. ("RCB") and its' Control Persons are referred to
herein as the "Reporting Person." RCB is a registered investment advisor engaged
in the business of securities analysis and

<PAGE>

investment and pursues an investment philosophy of identifying undervalued
companies and purchasing shares of these companies. In order to achieve its
clients' investment objectives, RCB may participate in discussions with company
management or third parties concerning significant matters in which RCB may
suggest possible courses of action to enhance shareholder value or cause
recognition of what RCB perceives to be the company's true value. In such
situations, RCB may acquire more than five percent of a company's equity
securities in order to play a more active role in corporate governance and
participate in discussions with third parties concerning proposed corporate
transactions.

RCB has elected to convert its filing on Schedule 13G to a filing on Schedule
13D to reflect its decision to enter into discussions with management and or
third parties that may relate to or result in, among other things, a change in
the Issuer's management, control, capitalization, the sale or transfer of a
material portion of the Issuer's assets, a merger, reorganization or other
similar transaction involving the Issuer (RCB has not developed specific plans
or proposals with respect to any of the foregoing but may do so in the future).
Through such actions RCB intends to seek to maximize the shareholder value of
the Issuer.

The Securities reported in this filing have been purchased and held for
investment purposes on behalf of client accounts over which RCB has
discretionary investment and voting power. In addition, the Reporting Person may
in the future acquire additional securities of the Issuer on behalf of RCB's
clients or dispose of some or all of RCB's current holdings of the Securities in
the ordinary course of RCB's business and the management of it's client
accounts.

Item 5.  Interest in Securities of the Issuer

(a) & (b) The Reporting Person has discretionary investment and voting power on
191,084 shares of common stock which constitutes approximately 5.43% of shares
outstanding. All ownership percentages herein assume that there are 3,520,000
shares outstanding.


(c)      Transactions made by RCB within the last sixty days:

<TABLE>
          <S>                <C>                       <C>      <C>
           Buy               07/18/2000                40       26.25
           Buy               07/19/2000                20       26.25
           Buy               07/20/2000                200      26.25
           Sell              07/21/2000                3000     25.905
           Sell              07/24/2000                3300     25.879
           Sell              07/27/2000                3620     27.189
           Buy               08/01/2000                220      23.375
           Buy               08/04/2000                260      18.75
           Sell              08/09/2000                50       21.75
           Sell              08/11/2000                100      19.625
           Buy               08/18/2000                50       22
           Sell              08/22/2000                230      21.375
           Buy               08/24/2000                40       21.125
           Sell              08/25/2000                2000     20.875
           Buy               08/28/2000                40       22.625
           Sell              08/29/2000                100      21.625
           Buy               08/29/2000                249      22.75
           Buy               09/01/2000                6790     26.472
           Buy               09/05/2000                850      27.59
           Sell              09/11/2000                1000     26.5
</TABLE>


Item 6.  Contracts, Arrangements, Understandings or Relationships
with Respect to Securities of the Issuer.

Reed, Conner & Birdwell, Inc. and its' Control Persons entered into a joint
filing agreement on March 2,

<PAGE>

2000.


Item 7.  Material to Be Filed as Exhibits

Exhibit 1 - Joint Filing Agreement by RCB and its' Control Persons.


Signature

After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true, complete and
correct.

Dated: September 18, 2000

Reed Conner & Birdwell, Inc.

By:  /S/ Donn B. Conner
----------------------------------
Donn B. Conner, President & CEO

By:  /S/ Jeffrey Bronchick
----------------------------------
Jeffrey Bronchick, CIO

By:  /S/ James C.  Reed
----------------------------------
James C. Reed, Executive VP

By:  /S/ James P. Birdwell
----------------------------------
James P. Birdwell, Executive VP
<PAGE>

Exhibit 1

JOINT FILING AGREEMENT PURSUANT TO RULE 13D-1(F)(1)


This agreement is made pursuant to Rule 13d-1(f)(1) under the Securities
Exchange Act of 1934 (the "Act") by and among the parties listed below, each
referred to herein as a "Joint Filer." The Joint Filers agree that a statement
of beneficial ownership as required by Section 13(d) of the Act and the Rules
there under may be filed on each of their behalf on Schedule 13D or Schedule
13G, as appropriate, and that said joint filing may thereafter be amended by
further joint filings. The Joint Filers states that they each satisfy the
requirements for making a joint filing under Rule 13d-1.


Dated: March 2, 2000


By: /S/ Donn B. Conner
-----------------------------------
Donn B. Conner, President & CEO


By: /S/ Jeffrey Bronchick
-----------------------------------
Jeffrey Bronchick, CIO


By: /S/ James C.  Reed
-----------------------------------
James C. Reed, Executive VP


By: /S/ James P. Birdwell
-----------------------------------
James P. Birdwell, Executive VP




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