AMERINDO INVESTMENT ADVISORS INC
SC 13D, 1996-04-12
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                       SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

                                  SCHEDULE 13D

                   Under the Securities Exchange Act of 1934
                               (Amendment No.  )*

                        HOUGHTON PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                                  COMMON STOCK
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   441502101
                        -------------------------------
                                 (CUSIP Number)

  Alberto W. Vilar, Amerindo Investment Advisors Inc., One Embarcadero Center,
     Suite 2300, San Francisco, CA 94111-3162;  Telephone:  (415) 362-0292
- --------------------------------------------------------------------------------
                 (Name, Address and Telephone Number of Persons
               Authorized to Receive Notices and Communications)

                                March 29, 1996
- --------------------------------------------------------------------------------
              (Date of Event which Requires Filing this Statement)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition which is the subject of this Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following space    .
                                                                       ---

Check the following space if a fee is being paid with the statement  X .  (A
                                                                    ---
fee is not required only if the reporting person:  (1) has a previous statement
on file reporting beneficial ownership of more than five percent of the class
of securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of such class.)
(See Rule 13d-7.)

NOTE:  Six copies of this statement, including all exhibits, should be filed
with the Commission.  See Rule 13d-1(a) for other parties to whom copies are to
be sent.

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).

                        (Continued on following page(s))




<PAGE>

CUSIP 
No.  441502101                         13D

- --------------------------------------------------------------------------------
  1  Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     AMERINDO INVESTMENT ADVISORS INC., a California corporation, AMERINDO
     ADVISORS (U.K.) LIMITED, AMERINDO INVESTMENT ADVISORS, INC., a Panama
     corporation, ALBERTO W. VILAR and GARY A. TANAKA, who disaffirm the
     existence of any group and who are sometimes collectively referred to as
     the "Reporting Persons."
- --------------------------------------------------------------------------------
  2  Check the Appropriate Box if a Member of a Group*            (a)   [ ]
                                                                  (b)   [ ]

- --------------------------------------------------------------------------------
  3  SEC Use Only

- --------------------------------------------------------------------------------
  4  Source of Funds*

     OO
- --------------------------------------------------------------------------------
  5  Check Box if Disclosure of Legal Proceedings is Required           [ ]

- --------------------------------------------------------------------------------
  6  Citizenship or Place of Organization

     See Item 6 of separate cover pages for Reporting Persons
- --------------------------------------------------------------------------------
                 7   Sole Voting Power

    Number of        None
     Shares    -----------------------------------------------------------------
  Beneficially   8   Shared Voting Power
    Owned By 
      Each           750,000 shares in the aggregate for all Reporting Persons
    Reporting        and as to all of which beneficial ownership is disclaimed
     Person    -----------------------------------------------------------------
      With       9   Sole Dispositive Power

                     None
               -----------------------------------------------------------------
                 10  Shared Dispositive Power 

                     750,000 shares in the aggregate for all Reporting Persons
                     and as to all of which beneficial ownership is disclaimed
- --------------------------------------------------------------------------------
 11  Aggregate Amount Beneficially Owned By Each Reporting Person

     750,000 shares in the aggregate for all Reporting Persons and as to all
     of which beneficial ownership is disclaimed
- --------------------------------------------------------------------------------
 12  Check Box if the Aggregate Amount in Row (11) excludes Certain
     Shares*                                                            [X]
- --------------------------------------------------------------------------------
 13  Percent of Class Represented by Amount in Row (11)

     6.0%
- --------------------------------------------------------------------------------
 14  Type of Reporting Person*

     IA
- --------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!




                                   - 2 of 12 -

<PAGE>

CUSIP
No.  441502101                        13D

- --------------------------------------------------------------------------------
  1  Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     AMERINDO INVESTMENT ADVISORS INC.
- --------------------------------------------------------------------------------
  2  Check the Appropriate Box if a Member of a Group*            (a)   [ ]
                                                                  (b)   [ ]

- --------------------------------------------------------------------------------
  3  SEC Use Only

- --------------------------------------------------------------------------------
  4  Source of Funds*

     OO
- --------------------------------------------------------------------------------
  5  Check Box if Disclosure of Legal Proceedings is Required           [ ]

- --------------------------------------------------------------------------------
  6  Citizenship or Place of Organization

     California
- --------------------------------------------------------------------------------
                 7   Sole Voting Power

    Number of        None
     Shares    -----------------------------------------------------------------
  Beneficially   8   Shared Voting Power
    Owned By
      Each           None
    Reporting
     Person    -----------------------------------------------------------------
      With       9   Sole Dispositive Power

                     None
               -----------------------------------------------------------------
                 10  Shared Dispositive Power

                     None
- --------------------------------------------------------------------------------
 11  Aggregate Amount Beneficially Owned By Each Reporting Person

     None
- --------------------------------------------------------------------------------
 12  Check Box if the Aggregate Amount in Row (11) excludes Certain
     Shares*                                                            [ ]

- --------------------------------------------------------------------------------
 13  Percent of Class Represented by Amount in Row (11)

     0.0%
- --------------------------------------------------------------------------------
 14  Type of Reporting Person*

     IA
- --------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!




                                   - 3 of 12 -

<PAGE>

CUSIP
No.  441502101                         13D

- --------------------------------------------------------------------------------
  1  Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     AMERINDO ADVISORS (U.K.) LIMITED
- --------------------------------------------------------------------------------
  2  Check the Appropriate Box if a Member of a Group*            (a)   [ ]
                                                                  (b)   [ ]

- --------------------------------------------------------------------------------
  3  SEC Use Only

- --------------------------------------------------------------------------------
  4  Source of Funds*

     OO
- --------------------------------------------------------------------------------
  5  Check Box if Disclosure of Legal Proceedings is Required           [ ]

- --------------------------------------------------------------------------------
  6  Citizenship or Place of Organization

     United Kingdom
- --------------------------------------------------------------------------------
                 7   Sole Voting Power

    Number of        None
     Shares    -----------------------------------------------------------------
  Beneficially   8   Shared Voting Power
    Owned By
      Each           None
    Reporting
     Person    -----------------------------------------------------------------
      With       9   Sole Dispositive Power

                     None
               -----------------------------------------------------------------
                 10  Shared Dispositive Power

                     None

- --------------------------------------------------------------------------------
 11  Aggregate Amount Beneficially Owned By Each Reporting Person

     None
- --------------------------------------------------------------------------------
 12  Check Box if the Aggregate Amount in Row (11) excludes Certain Shares*
                                                                        [ ]
- --------------------------------------------------------------------------------
 13  Percent of Class Represented by Amount in Row (11)

     0.0%
- --------------------------------------------------------------------------------
 14  Type of Reporting Person*

     IA
- --------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!




                                   - 4 of 12 -

<PAGE>

CUSIP 
No.  441502101                         13D

- --------------------------------------------------------------------------------
  1  Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     AMERINDO INVESTMENT ADVISORS, INC.
- --------------------------------------------------------------------------------
  2  Check the Appropriate Box if a Member of a Group*            (a)   [ ]
                                                                  (b)   [ ]

- --------------------------------------------------------------------------------
  3  SEC Use Only

- --------------------------------------------------------------------------------
  4  Source of Funds*

     OO
- --------------------------------------------------------------------------------
  5  Check Box if Disclosure of Legal Proceedings is Required           [ ]

- --------------------------------------------------------------------------------
  6  Citizenship or Place of Organization

     Panama
- --------------------------------------------------------------------------------
                 7   Sole Voting Power

    Number of        None
     Shares    -----------------------------------------------------------------
  Beneficially   8   Shared Voting Power
    Owned By
      Each           750,000 shares, as to all of which beneficial ownership
    Reporting        is disclaimed
     Person    -----------------------------------------------------------------
      With       9   Sole Dispositive Power

                     None
               -----------------------------------------------------------------
                 10  Shared Dispositive Power

                     750,000 shares, as to all of which beneficial ownership
                     is disclaimed
- --------------------------------------------------------------------------------
 11  Aggregate Amount Beneficially Owned By Each Reporting Person

     750,000 shares, as to all of which beneficial ownership is disclaimed
- --------------------------------------------------------------------------------
 12  Check Box if the Aggregate Amount in Row (11) excludes Certain Shares* 
                                                                       [X]

- --------------------------------------------------------------------------------
 13  Percent of Class Represented by Amount in Row (11)

     6.0%
- --------------------------------------------------------------------------------
 14  Type of Reporting Person*

     IA
- --------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!




                                   - 5 of 12 -

<PAGE>

CUSIP
No.  441502101                         13D

- --------------------------------------------------------------------------------
  1  Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     ALBERTO W. VILAR
- --------------------------------------------------------------------------------
  2  Check the Appropriate Box if a Member of a Group*            (a)   [ ]
                                                                  (b)   [ ]

- --------------------------------------------------------------------------------
  3  SEC Use Only

- --------------------------------------------------------------------------------
  4  Source of Funds*

     OO
- --------------------------------------------------------------------------------
  5  Check Box if Disclosure of Legal Proceedings is Required           [ ]

- --------------------------------------------------------------------------------
  6  Citizenship or Place of Organization

     United States
- --------------------------------------------------------------------------------
                 7   Sole Voting Power

    Number of        None
     Shares    -----------------------------------------------------------------
  Beneficially   8   Shared Voting Power
    Owned By
      Each           750,000 shares, as to all of which beneficial ownership
    Reporting        is disclaimed
     Person    -----------------------------------------------------------------
      With       9   Sole Dispositive Power

                     None
               -----------------------------------------------------------------
                 10  Shared Dispositive Power

                     750,000 shares, as to all of which beneficial ownership
                     is disclaimed
- --------------------------------------------------------------------------------
 11  Aggregate Amount Beneficially Owned By Each Reporting Person

     750,000 shares, as to all of which beneficial ownership is disclaimed
- --------------------------------------------------------------------------------
 12  Check Box if the Aggregate Amount in Row (11) excludes Certain Shares*
                                                                         [X]

- --------------------------------------------------------------------------------
 13  Percent of Class Represented by Amount in Row (11)

     6.0%
- --------------------------------------------------------------------------------
 14  Type of Reporting Person*

     IN
- --------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!




                                   - 6 of 12 -

<PAGE>

CUSIP 
No.  441502101                         13D

- --------------------------------------------------------------------------------
  1  Name of Reporting Person
     S.S. or I.R.S. Identification No. of Above Person

     GARY A. TANAKA
- --------------------------------------------------------------------------------
  2  Check the Appropriate Box if a Member of a Group*            (a)   [ ]
                                                                  (b)   [ ]

- --------------------------------------------------------------------------------
  3  SEC Use Only

- --------------------------------------------------------------------------------
  4  Source of Funds*

     OO
- --------------------------------------------------------------------------------
  5  Check Box if Disclosure of Legal Proceedings is Required           [ ]

- --------------------------------------------------------------------------------
  6  Citizenship or Place of Organization

     United States
- --------------------------------------------------------------------------------
                 7   Sole Voting Power

    Number of        None
     Shares    -----------------------------------------------------------------
  Beneficially   8   Shared Voting Power
    Owned By
      Each           750,000 shares, as to all of which beneficial ownership
    Reporting        is disclaimed
     Person    -----------------------------------------------------------------
      With       9   Sole Dispositive Power

                     None
               -----------------------------------------------------------------
                 10  Shared Dispositive Power

                     750,000 shares, as to all of which beneficial ownership
                     is disclaimed
- --------------------------------------------------------------------------------
 11  Aggregate Amount Beneficially Owned By Each Reporting Person

     750,000 shares, as to all of which beneficial ownership is disclaimed
- --------------------------------------------------------------------------------
 12  Check Box if the Aggregate Amount in Row (11) excludes Certain Shares*
                                                                        [X]

- --------------------------------------------------------------------------------
 13  Percent of Class Represented by Amount in Row (11)

     6.0%
- --------------------------------------------------------------------------------
 14  Type of Reporting Person*

     IA
- --------------------------------------------------------------------------------

                     *SEE INSTRUCTIONS BEFORE FILLING OUT!




                                   - 7 of 12 -

<PAGE>

ITEM 1.   Security and Issuer.
          -------------------

          The class of equity securities to which this statement relates is the
Common Stock of Houghton Pharmaceuticals, Inc. ("the Issuer"), whose principal
executive offices are located at 3550 General Atomics Court, San Diego, CA,
92121.


ITEM 2.   Identity and Background.
          -----------------------

          This statement is being filed by Amerindo Investment Advisors Inc., a
California corporation whose principal executive offices are located at One
Embarcadero Center, Suite 2300, San Francisco, California, 94111 ("Amerindo"),
Amerindo Advisors (U.K.) Limited, a United Kingdom corporation whose principal
executive offices are located at 43 Upper Grosvenor Street, London WIX 9PG
England ("Amerindo UK"), Amerindo Investment Advisors, Inc., a Panama
corporation, whose principal executive offices are located at Edificio Sucre,
Calle 48 Este, Bella Vista, Apartado 6277, Panama 5, Panama ("Amerindo Panama")
and Alberto W. Vilar and Gary A. Tanaka.  Although this statement is being made
jointly by Amerindo, Amerindo UK, Amerindo Panama and Messrs. Vilar and Tanaka,
each of them expressly disaffirms membership in any group under Rule 13d-5 under
the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or
otherwise.

          Amerindo is registered as an investment advisor under the Investment
Advisors Act of 1940, as amended, and Amerindo UK is registered with the
Investment Management Regulatory Organization in the United Kingdom.  Messrs.
Alberto W. Vilar and Gary A. Tanaka, whose business addresses are the same as
those set forth for Amerindo and Amerindo UK and each of whom is a U.S. 
citizen, are the only directors and executive officers of Amerindo U.K. and 
Amerindo Panama. They are also the only directors and executive officers of 
Amerindo, other than Messrs. Charles B. Young and James H. Furey, Co-Chief 
Operating Officers, and Mr. Joaquin Garcia-Larrieu, Chief Financial Officer.  
Mr. Young's business address is at Amerindo's offices at 399 Park Avenue, New 
York, New York 10022, as is Mr. Furey's, and Mr. Garcia's business address is 
Gables International Plaza, 2655 Le Jeune Road, Suite 1112, Coral Gables, FL 
33134.  Amerindo, Amerindo UK, Amerindo Panama and Messrs. Vilar and Tanaka are
sometimes hereinafter collectively referred to as the "Reporting Persons." 
Messrs. Vilar, Tanaka, Young, Furey and Garcia are sometimes hereinafter 
collectively referred to as the "Other Named Individuals."

          During the last five years, none of the Reporting Persons or Other
Named Individuals has been convicted in a criminal proceeding (excluding traffic
violations or similar misdemeanors), nor has any such individual or entity been
a party to a civil proceeding of a judicial or administrative body of competent
jurisdiction as a result of which proceeding such individual or entity was or is
subject to a judgment, decree or final order enjoining future violations of, or
prohibiting or mandating activities subject to, Federal or state securities laws
or finding any violation with respect to such laws.

ITEM 3.   Source and Amounts of Funds or Other Consideration.
          --------------------------------------------------

          All purchases of the subject securities by the Reporting Persons have
been in the ordinary course of the respective businesses of Amerindo, Amerindo
U.K. and Amerindo Panama (collectively, the "Advisor Entities") as investment
advisors.  Accordingly, the funds used to purchase the subject securities have
been client funds pertaining to accounts under management.  Purchases of the
Issuer's securities by the Named Individuals would all be and have all been made
with their personal funds, except that margin credit may also be, and may have
been, employed.




                                   - 8 of 12 -

<PAGE>

ITEM 4.   Purpose of Transaction.
          ----------------------

          All of the subject securities have been purchased by the Advisor
Entities in the ordinary course of their respective businesses as investment
advisors and not with the purpose of effecting changing or influencing the
control of the issuer or in connection with or as a participant in any
transaction having such purpose or effect, including any transaction subject to
Rule 13d-3(b) under the Exchange Act.  Additionally, because each of the Advisor
Entities is obligated to act in the best interests of its respective clients and
in accordance with the respective mandates of those clients, there is no
agreement between or among any of the Reporting Persons to act together with
respect to the Issuer or its securities, except that they may, from time to time
and provided that transactions are otherwise being effected at the same time,
aggregate orders for client accounts in order to receive more favorable trading
terms.  Any of the subject securities acquired or which might in the future be
acquired by any of the Named Individuals have been and would be acquired for
investment and not with the purpose of effecting of changing or influencing the
control of the issuer or in connection with or as a participant in any
transaction having such purpose or effect, including any transaction subject to
Rule 13d-3(b) under the Exchange Act.

ITEM 5.   Interest in Securities of Issuer.
          --------------------------------

          (a)  See Exhibit "A" attached hereto for information setting forth for
each of Reporting Persons and for each Named Individual the aggregate number of
shares of the Common Stock of Issuer beneficially owned by such person as of
April 4, 1996, and the percentage which such shares constitute of the total
number of shares outstanding, as reflected on Issuer's Form 10-K for the year
ended December 31, 1995, unless information has been obtained as of a later
date directly from the Issuer (with beneficial ownership determined as set forth
in Rule 13d-3 under the Exchange Act, but disclaimed as set forth in the
Exhibit).

          (b)  Messrs. Vilar and Tanaka share voting and dispositive power over
all shares shown as owned by any of the Reporting Persons; however, each client
of the Advisor Entities has the unilateral right to terminate the advisory
arrangement with the Entity in question on notice which typically need not
exceed 30 days.  Each of the Other Named Individuals has sole voting and
dispositive power as to the shares shown in Exhibit "A" as owned by him.

          (c)  The table contained in Exhibit "B" attached hereto sets forth for
each of the Reporting Persons and Named Individuals information concerning all
acquisitions and dispositions of Issuer's Common Stock by any such person during
the period beginning on February 1, 1996, and ending on April 4, 1996, including
(i) the date of the transaction, (ii) whether the transaction was a purchase or
sale, (iii) the number of shares involved, and (iv) the price per share at which
the transaction was effected.  All transactions were effected on the open
market.

          (d)  The shares covered by this statement are all owned by clients of
the Advisor Entities.  No such person's interest in the securities included in
this statement exceeds 5% of the class outstanding.

          (e)  Inapplicable.

ITEM 6.   Contracts, Arrangements, Understandings or
          Relationships with Respect to Securities
          of the Issuer.
          ------------------------------------------

          Messrs. Vilar and Tanaka are the sole shareholders and directors of
each of the Advisor Entities.  As stated above, clients of those Entities
generally have the right to terminate their investment advisory arrangements
with those Entities on notice of 30 days or less.




                                   - 9 of 12 -

<PAGE>

ITEM 7.   Material to be Filed as Exhibits.
          --------------------------------

          Inapplicable.

                                   SIGNATURES

          After reasonable inquiry and to the best of our knowledge and belief,
we certify that the information set forth in this statement is true, complete
and correct.


                                        AMERINDO INVESTMENT ADVISORS INC.,
                                        a California corporation


                                        By:  /s/ Alberto W. Vilar
                                            ------------------------------------
                                             ALBERTO W. VILAR, PRESIDENT

                                        AMERINDO INVESTMENT ADVISORS (U.K.),
                                        LIMITED, a United Kingdom corporation


                                        By:  /s/ Alberto W. Vilar
                                            ------------------------------------
                                             ALBERTO W. VILAR, DIRECTOR

                                        AMERINDO INVESTMENT ADVISORS INC.,
                                        a Panama corporation


                                        By:  /s/ Alberto W. Vilar
                                            ------------------------------------
                                             ALBERTO W. VILAR, DIRECTOR


                                        By:  /s/ Alberto W. Vilar
                                            ------------------------------------
                                             ALBERTO W. VILAR


                                        By:  /s/ Gary A. Tanaka
                                            ------------------------------------
                                             GARY A. TANAKA




                                   - 10 of 12 -

<PAGE>

                                   EXHIBIT A

                         HOUGHTON PHARMACEUTICALS, INC.

                                  COMMON STOCK

                                   441502101

          The following table sets forth for each of the Reporting Persons and
for each Other Named Individual the aggregate number of shares of the Common
Stock of the Issuer beneficially owned by such person as of April 4, 1996, and
the percentage which such shares constitute of the total number of shares
outstanding, as reflected on the Issuer's Form 10-K for the year ended
December 31, 1995, unless based on more recent information obtained directly
from the Issuer (with beneficial ownership determined as set forth in Rule
13d-3 under the Exchange Act, but disclaimed as set forth in the footnote):

NAME                     NO. OF SHARES(1)                       PERCENT OF CLASS
- ----                     ----------------                       ----------------

Amerindo                            0                                       0.0%

Amerindo UK                         0                                       0.0%

Amerindo Panama               750,000                                       6.0%

Alberto W. Vilar              750,000                                       6.0%

Gary A. Tanaka                750,000                                       6.0%

Charles B. Young                    0                                       0.0%

James H. Furey                      0                                       0.0%

Joaquin Garcia                      0                                       0.0%


____________________________________

(1)  Messrs. Vilar and Tanaka, as the sole directors and shareholders of each of
the Advisor Entities, share voting and investment power as to all shares shown
as owned by the Advisor Entities, but they and the Advisor Entities disclaim
ownership of any of such shares.  Each client of the Advisor Entities has the
unilateral right to terminate the advisory arrangement with the Entity in
question on notice which typically need not exceed 30 days.




                                   - 11 of 12 -

<PAGE>

                                   EXHIBIT B

                         HOUGHTON PHARMACEUTICALS, INC.

                                  COMMON STOCK

                                   441502101

          The following table sets forth for each of the Reporting Persons and
Other Named Individuals information concerning all acquisitions and dispositions
of the Issuer's Common Stock by any such person during the period beginning on
February 1, 1996, and ending on April 4, 1996, including (i) the date of the
transaction, (ii) whether the transaction was a purchase of sale, (iii) the
number of shares involved, and (iv) the price per share at which the transaction
was effected.  All transactions were effected on the open market.

                                         Type of         Number       Price
      Name                 Date        Transaction     of Shares     per Share
      ----                 ----        -----------     ---------     ---------
Amerindo Panama           03/29/96         Buy          750,000         8.00




                                   - 12 of 12 -



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