PRUDENTIAL MULTI SECTOR FUND INC
24F-2NT, 1996-06-27
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                                                    June 25, 1996

Securities and Exchange Commission
450 Fifth Street, NW
Washington, DC  20549

     Re:  Rule 24f-2 Notice for Prudential Multi-Sector Fund,
          Inc. (File No. 811-06047)
          
     On behalf of Prudential Multi-Sector Fund, Inc. , enclosed
for filing under the Investment Company Act of 1940 are:

     (1)  One copy of the Rule 24f-2 Notice; and

     (2)  Opinion of counsel to the Fund.

     These documents have been filed using the EDGAR system. The
fee in the amount of $48,510.69 was sent by wire transfer to the
Commission's lockbox depository on June 24, 1996.

     Please acknowledge receipt of this filing by stamping a copy
of this letter and returning it in the enclosed self-addressed
postage paid envelope.

                                   Very truly yours,




                                   /s/Marguerite E. H. Morrison
                                   Marguerite E.H. Morrison
                                   Assistant Secretary
                                   
MM/ln
Enclosures





          U.S. SECURITIES AND EXCHANGE COMMISSION
                   Washington, D.C. 20549
                   
                         FORM 24F-2
              Annual Notice of Securities Sold
                   Pursuant to Rule 24f-2
                   
  Read instructions at end of Form before preparing Form. Please
                   print or type.
  1.   Name and address of issuer: Prudential Multi-Sector Fund,
       Inc., One Seaport Plaza, New York, New York  10292.
                                
  2.   Name of each series or class of funds for which this
       notice is filed:  The Fund offers four classes of shares
       designated Class A, Class B, Class C and Class Z.
       
  3.   Investment Company Act File Number: 811-06047.
       Securities Act File Number: 33-33477.
  4.   Last day of fiscal year for which this notice is filed:
       April 30, 1996.

  5.   Check box if this notice is being filed more than 180
       days after the close of the issuer's fiscal year for
       purposes of reporting securities sold after the close of
       the fiscal year but before termination of the issuer's 24f-
       2 declaration:
                                                    [ ]
  6.   Date of termination of issuer's declaration under rule
        24f-2(a)(1), if applicable (see instruction A.6):
                                
  7.   Number and amount of securities of the same class or
       series which had been registered under the Securities Act
       of 1933 other than pursuant to rule 24f-2 in a prior
       fiscal year, but which remained unsold at the beginning of
       the fiscal year: None
       
  8.   Number and amount of securities registered during the
       fiscal year other than pursuant to rule 24f-2: None
                                
  9.   Number and aggregate sale price of securities sold during
       the fiscal year: 25,009,646/$299,947,382

10.    Number and aggregate sale price of securities sold during
       the fiscal year in reliance upon registration pursuant to
       rule 24f-2:25,009,646/$299,947,382
       
    11.   Number and aggregate sale price of securities issued
          during the fiscal year in connection with dividend
          reinvestment plans, if applicable
          (see instruction B.7):3,215,345/$42,592,536
                               
    12.   Calculation of registration fee:

         (i)  Aggregate sale price of securities
              sold during the fiscal year in
              reliance on rule 24f-2 (from item 10):  $299,947,382
        (ii)  Aggregate price of shares issued in
              connection with dividend reinvestment
              plans (from item 11, if applicable):  +$42,592,536
       (iii)  Aggregate price of shares redeemed or
              repurchased during the fiscal year
              (if applicable):                      -$201,858,921
        (iv)  Aggregate price of shares redeemed or
              repurchased and previously applied as a
              reduction to filing fees pursuant to rule 24e-2
              (if applicable):                      +  0
            (v)  Net aggregate price of securities
              sold and issued during the fiscal
              year in reliance of rule 24f-2 [line (i), plus line (ii),
              less line (iii), plus line (iv)]
(if applicable):                                    $140,680,997
        (vi)  Multiplier prescribed by section
              6(b) of the Securities Act of 1933
              or other applicable law or regulation
              (see instruction C.6):                x1/2900
       (vii)  Fee due [line (i) or line (v)
              multiplied by line (vi)]:             $48,510.69

Instructions:  Issuers should complete lines (ii), (iii), (iv) and (v) only if
               the form is being filed within 60 days after the close of the
               issuer's fiscal year.  See Instruction C.3.
               
    13.   Check box if fees are being remitted to the Commission's
          lockbox depository as described in section 3a of the
          Commission's Rules of Informal and Other Procedures
          (17 CFR 202.3a).
                                              [X]
          Date of mailing or wire transfer of filing fees to the
          Commission's lockbox depository: June 21, 1996
                            SIGNATURES
This report has been signed below by the following persons on
behalf of the issuer and in the capacities and on the dates
indicated.



                                   /s/S. Jane Rose
                                   By (S. Jane Rose, Secretary)
                                   
                                   
 Date June 25, 1996








                   GARDNER, CARTON & DOUGLAS Suite 3400 - Quaker Tower
                     321 North Clark Street
                 Chicago, Illinois  60610-4795 (312) 644-3000
                  Telecopier:  (312) 644-3381
                         June 24, 1996
Securities and Exchange Commission
450 Fifth Street, N.W.
Judiciary Plaza
Washington, D.C.  20549

          Re:  Prudential Multi-Sector Fund, Inc. Rule 24f-2
               Notice to Form N-1A
Registration Statement File No. 33-33477

Ladies and Gentlemen:

     As counsel for Prudential Multi-Sector Fund, Inc., a
Maryland corporation (the "Fund"), we have examined the
proceedings taken and being taken with respect to the Notice
filed by the Fund pursuant to Rule 24f-2 under the Investment
Company Act of 1940 (the "Act"), making definite in number the
shares registered pursuant to that Rule for the fiscal year ended
April 30, 1996.

     We have examined all instruments, documents and records
which, in our opinion, were necessary of examination for the
purpose of rendering this opinion.  Based upon such examination,
we are of the opinion that the 25,009,646 shares of common stock,
$.001 par value per share, which were registered in indefinite
number and sold in reliance on Rule 24f-2 under the Act were,
when issued by the Fund, validly authorized and issued, fully
paid and non-assessable.

    We hereby consent to the filing of this opinion pursuant to Rule
                       24f-2 and to the reference
to us in the Notice filed herewith.

                              Very truly yours,
                              /s/ GARDNER, CARTON & DOUGLAS
PHD/KJF/cav



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