HYBRIDON INC
10-Q, 1998-11-16
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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    As filed with the Securities and Exchange Commission on November 16, 1998

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 10-Q

                        QUARTERLY REPORT UNDER SECTION 13
                 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

                                     -------


For the Quarter Ended:  September 30, 1998       Commission File Number 0-27352

                                 Hybridon, Inc.
                                 --------------
             (Exact name of registrant as specified in its charter)


           Delaware                                    04-3072298
           --------                                    ----------
(State or other jurisdiction of          (I.R.S. Employer Identification Number)
organization or incorporation)

                                155 Fortune Blvd.
                                Milford, MA 01757
                                -----------------
          (Address of principal executive offices, including zip code)


                                 (508) 482-7500
                                 --------------
              (Registrant's telephone number, including area code)


Indicate by check mark  whether the  registrant  (1) has filed all reports to be
filed by Section 13 or 15(d) of the  Securities  Exchange Act of 1934 during the
preceding 12 months (or for such shorter period that the registrant was required
to file such reports),  and (2) has been subject to such filing requirements for
the past 90 days.

                             YES [X]     NO [_]

Indicate the number of shares  outstanding  of each of the  issuer's  classes of
common stock, as of the latest practicable date.

Common Stock, par value $.001 per share              15,256,825           
- - ---------------------------------------       -----------------------
              Class                      Outstanding as of November 13, 1998




                                        1

<PAGE>



                                 HYBRIDON, INC.

                                    Form 10-Q

                                      INDEX


Part I - Financial Information

Item 1 - Financial Statements

        Consolidated  Condensed  Balance  Sheets as of  September  30, 1998 and
        December 31, 1997.

        Consolidated  Condensed  Statements of Operations  for the Three Months
        ended and Nine Months ended  September 30, 1998 and 1997 and Cumulative
        from May 25, 1989 (Inception) to September 30, 1998

        Consolidated  Condensed  Statements  of Cash Flows for the Nine  Months
             ended  September 30, 1998 and 1997 and  Cumulative  from May 25,
             1989 (Inception) to September 30, 1998

        Notes to Consolidated Condensed Financial Statements

Item 2 - Management's Discussion and Analysis of
              Financial Condition and Results of Operations

Part II - Other Information

Items 1 through 4 - None

Item 5 - Other Information

Item 6 - Exhibits and Reports on Form 8-K.

Signatures


                                        2

<PAGE>



                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)

                      CONSOLIDATED CONDENSED BALANCE SHEETS

                                   (UNAUDITED)
<TABLE>
<CAPTION>

                                                   ASSETS
                                                                              September 30,    December 31,
                                                                                  1998             1997
<S>                                                                          <C>              <C>            
CURRENT ASSETS:
         Cash and cash equivalents                                               $   882,825      $ 2,202,202
         Accounts receivable                                                         825,668          529,702
         Accounts receivable related to real estate limited partnership            5,450,000               --
         Prepaid expenses and other current assets                                   448,372        1,005,825
                                                                                 -----------      -----------


                  Total current assets                                             7,606,865        3,737,729
                                                                                 -----------      -----------


PROPERTY AND EQUIPMENT, NET                                                        8,953,117       19,230,804
                                                                                 -----------      -----------


OTHER ASSETS:
         Restricted cash                                                             659,618        3,050,982
         Notes receivable from officers                                              255,800          247,250
         Deferred financing costs and other assets                                   923,162        3,354,767
         Investment in real estate partnership                                            --        5,450,000
                                                                                 -----------      -----------


                                                                                   1,838,580       12,102,999
                                                                                 -----------      -----------


                                                                                 $18,398,562      $35,071,532
                                                                                 ===========      ===========

                              LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)

CURRENT LIABILITIES:
 Current portion of long-term debt and capital lease obligations               $   3,030,981   $    7,868,474
 Accounts payable                                                                  4,387,353        8,051,817
 Accrued expenses                                                                  3,003,934       11,917,298
                                                                               -------------    -------------
                                                                                              
         Total current liabilities                                                10,422,268       27,837,589
                                                                               -------------    -------------
                                                                                              
                                                                                              
LONG-TERM DEBT AND CAPITAL LEASE OBLIGATIONS, NET OF CURRENT PORTION                 573,017        3,282,123
                                                                               -------------    -------------
                                                                                              
9% CONVERTIBLE SUBORDINATED NOTES PAYABLE                                          1,306,000       50,000,000
                                                                               -------------    -------------
                                                                                             

STOCKHOLDERS' EQUITY(DEFICIT):
 Preferred stock, $.01 par value-
         Authorized--5,000,000 shares
         Issued and outstanding--None                                                     --              --

Series A convertible preferred stock, $.01 par value-
         Authorized--5,000,000 shares
         Issued and outstanding--624,790 shares at September 30, 1998                  6,248              --
 Common stock, $.001 par value-
         Authorized--100,000,000 shares
         Issued and outstanding--15,254,825 and 5,059,650 shares at
         September  30, 1998, and  December 31, 1997, respectively                    15,255            5,060
 Additional paid-in capital                                                      240,301,274      173,695,698
 Deficit accumulated during the development stage                               (233,294,707)    (218,655,101)
 Deferred compensation                                                              (930,793)      (1,093,837)
                                                                               -------------    -------------
                                                                                              
                                                                                              
         Total stockholders' equity(deficit)                                       6,097,277      (46,048,180)
                                                                               -------------    -------------
                                                                                              
                                                                                              
                                                                              $   18,398,562   $   35,071,532
                                                                               =============    =============


 The accompanying notes are an integral part of these consolidated condensed financial statements.



                                       3

<PAGE>



                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)

                 CONSOLIDATED CONDENSED STATEMENTS OF OPERATIONS

                                   (UNAUDITED)

                                                                                                                   
                                                                                                                    Cumulative
                                                                                                                       from
                                                                                                                    May 25, 1989
                                                Three Months Ended                   Nine Months Ended             (Inception) to
                                                  September 30,                        September 30,               September 30,
                                              1998              1997               1998              1997               1998
<S>                                    <C>               <C>                <C>               <C>                <C>            
REVENUES:
 Research and development                        $    150,000     $    200,000     $    949,915     $     980,150     $   6,449,178
 Product and service revenue                          846,746          155,368        2,353,435         1,231,226         5,310,472
 Interest income                                       44,010          294,246          106,457           898,160         3,327,196
 Royalty and other income                                  --           18,247               --            33,218           110,321
                                                 ------------     ------------     ------------     -------------     -------------


                                                    1,040,756          667,861        3,409,807         3,142,754        15,197,167
                                                 ------------     ------------     ------------     -------------     -------------


OPERATING EXPENSES:
 Research and development                           5,201,246       11,338,913       17,180,927        37,784,718       182,640,742
 General and administrative                         1,503,845        3,057,380        5,217,864         9,011,879        53,034,480
 Restructuring charge                                      --        3,100,000               --         3,100,000        11,020,000
 Interest                                             296,344        1,605,918        2,880,307         3,223,473         9,026,337
                                                 ------------     ------------     ------------     -------------     -------------


                                                    7,001,435       19,102,211       25,279,098        53,120,070       255,721,559
                                                 ------------     ------------     ------------     -------------     -------------


         Loss from operations                      (5,960,679)     (18,434,350)     (21,869,291)      (49,977,316)     (240,524,392)

EXTRAORDINARY ITEM:
 Gain on conversion of 9% convertible                      
 subordinated notes                                        --               --        8,876,685                --         8,876,685
                                                 ------------     ------------     ------------     -------------     -------------


NET LOSS                                         $ (5,960,679)    $(18,434,350)    $(12,992,606)    $ (49,977,316)    $(231,647,707)
                                                 ============     ============     ============     =============     ============= 



BASIC AND DILUTED LOSS
PER COMMON SHARE  FROM
(Note 3):

     OPERATIONS                                  $    (0.39)      $      (3.65)     $     (2.05)    $     (9.90)

     EXTRAORDINARY GAIN                                  --                 --             0.83              --
                                                 --------------   --------------    --------------  --------------


     NET LOSS                                    $    (0.39)      $      (3.65)     $     (1.22)    $     (9.90)
                                                 ==============   ==============    ==============  ==============

                                     
SHARES USED IN COMPUTING BASIC                     15,254,825         5,055,513         10,648,116       5,046,806
AND DILUTED NET LOSS PER COMMON                  ==============   ==============    ==============  ===============
SHARE (Note 3)
              

         The accompanying notes are an integral part of these consolidated condensed financial statements


                                       4

<PAGE>

                                          HYBRIDON, INC. AND SUBSIDIARIES
                                           (A Development Stage Company)

                                  CONSOLIDATED CONDENSED STATEMENTS OF CASH FLOWS

                                                    (UNAUDITED)

                                                                                                      Cumulative
                                                                                                         from
                                                                                                     May 25, 1989
                                                                    Nine Months Ended               (inception) to
                                                                      September 30,                  September 30,
                                                                  1998             1997                  1998
                                                                  ----             ----                  ----
<S>                                                         <C>                 <C>                   <C>           
CASH FLOWS FROM OPERATING ACTIVITIES:                                                          
Net loss                                                    $(12,992,606)       $(49,977,316)       $(231,647,707)
Adjustments to reconcile net loss to net cash
used in operating activities--
 Extraordinary gain on conversion of 9% convertible
   subordinated notes payable                                 (8,876,685)                 --           (8,876,685)
 Depreciation and amortization                                 2,419,269           4,081,720           13,605,723
 Loss on disposal of fixed assets                                424,675                  --              424,675
 Issuance of common stock for services rendered                1,195,398             146,875            1,342,273
 Compensation on grant of stock options, warrants and
    restricted stock                                             163,044             261,519            8,286,842
 Amortization of discount on convertible promissory notes
    payable                                                           --                  --              690,157
 Amortization of deferred financing costs                        240,611             358,904              937,080
 Noncash interest on convertible promissory notes payable             --                  --              260,799
 Write-down of assets related to restructuring                 6,600,000             331,000            7,200,000
 Changes in operating assets and liabilities-
   Accounts receivable                                          (295,966)            276,545             (825,668)
   Prepaid and other current assets                              557,703            (541,718)            (448,122)
   Notes receivable from officers                                 (8,550)             55,952             (255,800)
   Amounts payable to related parties                                 --                  --             (200,000)
   Accounts payable and accrued expenses                      (6,871,326)          3,349,962           13,097,789
   Deferred revenue                                                   --             (86,250)                  --
                                                            ------------        ------------        -------------


 Net cash used in operating activities                       (17,444,433)        (41,742,807)        (196,408,644)
                                                            ------------        ------------        -------------


CASH FLOWS FROM INVESTING ACTIVITIES:
 Increase in short-term investments                                   --          (5,113,569)                  --
 Purchases of property and equipment, net                       (340,507)         (6,645,439)         (29,652,972)
 Proceeds from sale of fixed assets                              460,000                  --              460,000
 Investment in real estate partnership                                --                  --           (5,450,000)
                                                            ------------        ------------        -------------


 Net cash provided by (used in) investing activities             119,493         (11,759,008)         (34,642,972)
                                                            ------------        ------------        -------------


CASH FLOWS FROM FINANCING ACTIVITIES:
 Proceeds from issuance of convertible preferred stock         6,804,562                  --          103,388,716
 Proceeds from issuance of common stock related to stock
   options and restricted stock grants                                --              83,327            1,260,928
 Proceeds from issuance of common stock related to stock
   warrants                                                           --               9,075            3,185,816
 Net proceeds from issuance of common stock                    6,876,676                  --           59,232,000
 Repurchase of common stock                                           --                  --                 (263)
 Proceeds from notes payable                                          --                  --            9,450,000
 Proceeds from issuance of convertible promissory notes
   payable                                                     4,233,832          50,000,000           63,425,576
 Proceeds from long-term debt                                         --                  --              662,107
 Payments on long-term debt and capital leases                (4,236,693)         (1,169,656)          (7,602,573)
 Proceeds from sale/leaseback                                         --           1,165,236            4,001,018
 Decrease (increase)  in restricted cash and other assets      2,327,186            (626,985)          (1,811,945)
 (Increase) decrease in deferred financing costs                      --          (2,699,957)          (3,256,939)
                                                            ------------        ------------        -------------


 Net cash provided by financing activities                    16,005,563          46,761,040          231,934,441
                                                            ------------        ------------        -------------


NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS          (1,319,377)         (6,740,775)             882,825

CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD                 2,202,202          12,633,742                   --
                                                            ------------        ------------        -------------


CASH AND CASH EQUIVALENTS, END OF PERIOD                    $    882,825        $  5,892,967        $     882,825
                                                            ============        ============        =============

SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION:
 Cash paid for interest                                     $  1,494,323        $    786,005        $   5,124,773
                                                            ============        ============        =============


 The accompanying notes are an integral part of these consolidated condensed financial statements.
</TABLE>


                                       5


<PAGE>


                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)
              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)



(1)      ORGANIZATION

 Hybridon, Inc. (the "Company") was incorporated in the State of Delaware on May
 25, 1989.  The Company is engaged in the  discovery  and  development  of novel
 genetic  medicines based primarily on antisense  technology.  The Company is in
 the development stage. Since inception,  the Company has been engaged primarily
 in  research  and  development   efforts,   development  of  its  manufacturing
 capabilities and organizational efforts, including recruiting of scientific and
 management personnel and raising capital. To date, the Company has not received
 revenue from the sale of  biopharmaceutical  products  developed by it based on
 antisense technology.  In order to commercialize its own products,  the Company
 will need to  address a number of  technological  challenges  and  comply  with
 comprehensive  regulatory  requirements.  Accordingly,  it is not  possible  to
 predict  the amount of funds that will be  required  or the length of time that
 will pass  before  the  Company  receives  revenues  from sales of any of these
 products.  Revenues received by the Company to date have been derived primarily
 from collaboration agreements,  interest on investment funds, revenues from the
 custom  contract  manufacturing  of synthetic  DNA and reagent  products by the
 Company's  Hybridon  Specialty  Products  Division.  As a result,  although the
 Company has begun to generate  revenues from its custom contract  manufacturing
 business,  the Company is dependent on the proceeds from possible  future sales
 of  equity   securities,   debt   financings   and  research  and   development
 collaborations in order to fund future operations.

 On May 5, 1998, the Company  completed a private offering of equity  securities
 raising total gross proceeds of  approximately  $27.3 million from the issuance
 of 9,597,476  shares of common  stock,  114,285  shares of Series A convertible
 preferred  stock and warrants to purchase  2,657,219  shares of common stock at
 $2.40 per share.  The gross proceeds  include the  conversion of  approximately
 $6.2  million  of  accounts  payable,   capital  lease  obligations  and  other
 obligations into common stock. The Company incurred  approximately $2.6 million
 of cash expenses  related to the private  offering and issued 597,699 shares of
 common stock and warrants to purchase 1,720,825 shares of common stock at $2.40
 per  share  to the  placement  agents.  The  compensation  received  by  Pillar
 Investments Ltd. ("Pillar"), a company affiliated with certain directors of the
 Company,  with respect to the offshore  component of the private  offering (the
 "Offshore  Offering")  consisted of (i) 9% of gross  proceeds of such  Offshore
 Offering  and (ii) a  non-accountable  expense  allowance  equal to 4% of gross
 proceeds of such Offshore Offering.  Pillar received approximately $1.6 million
 and warrants to purchase 1,111,630 shares of common stock at $2.40 per share.

 On February 6, 1998, the Company  commenced an exchange offer to the holders of
 the 9% Convertible Subordinated Notes (the "9% Notes") (see Note 6) to exchange
 the 9% Notes for Series A convertible  preferred stock and certain  warrants of
 the Company. On May 5, 1998, noteholders holding $48.7 million of principal and
 $2,361,850 of accrued interest  tendered such principal and accrued interest to
 the Company  for 510,505  shares of Series A  convertible  preferred  stock and
 warrants to purchase 3,002,958 shares of common stock with an exercise price of
 $4.25 per share. In accordance with Statement of Financial  Accounting ("SFAS")
 No.15,  Accounting by Debtors and  Creditors for Troubled Debt  Restructurings,
 the Company  recorded  an  extraordinary  gain of  approximately  $8.9  million
 related to the  conversion.  The  extraordinary  gain represents the difference
 between the  carrying  value of the 9% Notes and the fair value of the Series A
 convertible  preferred  stock,  as  determined  by the per share sales price of
 Series A convertible  preferred  stock sold in the private  offering  described
 above, and warrants to purchase common stock issued by the Company.



                                       6
<PAGE>

(2)      UNAUDITED INTERIM FINANCIAL STATEMENTS

                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)
              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)


The unaudited  consolidated  condensed financial statements included herein have
been  prepared  by  the  Company,  without  audit,  pursuant  to the  rules  and
regulations  of the  Securities  and Exchange  Commission  and  include,  in the
opinion  of  management,  all  adjustments,   consisting  of  normal,  recurring
adjustments,  necessary  for a fair  presentation  of  interim  period  results.
Certain  information  and footnote  disclosures  normally  included in financial
statements prepared in accordance with generally accepted accounting  principles
have been  condensed  or omitted  pursuant  to such rules and  regulations.  The
Company  believes,  however,  that  its  disclosures  are  adequate  to make the
information  presented  not  misleading.  The results  for the  interim  periods
presented are not necessarily  indicative of results to be expected for the full
fiscal  year.  It is  suggested  that  these  financial  statements  be  read in
conjunction with the audited consolidated financial statements and notes thereto
included in the Company's Annual Report on Form 10-K for the year ended December
31, 1997, as filed with the Securities and Exchange Commission.

(3) SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Net Loss per Common Share 

The Company applies SFAS No. 128,  Earnings per Share,  in calculating  earnings
per share.  Basic net loss per share is  computed  by  dividing  net loss by the
weighted average number of common shares outstanding during the period.  Diluted
net loss per share for the periods  presented  is the same as basic net loss per
share as the  inclusion  of the  potential  common  stock  equivalents  would be
antidilutive.

(4) CASH EQUIVALENTS

The Company applies SFAS No. 115, Accounting for Certain Investments in Debt and
Equity Securities.  Under SFAS No. 115, debt securities that the Company has the
positive  intent and ability to hold to maturity are recorded at amortized  cost
and are classified as held-to-maturity securities. These securities include cash
equivalents and restricted cash. Cash  equivalents  have original  maturities of
less than three  months.  Cash and cash  equivalents  at September  30, 1998 and
December 31, 1997  consisted of the following:  

                                                    September 30,   December 31,
                                                        1998           1997

Cash and cash equivalents
    Cash and money market funds                      $  400,949       $1,702,272
    Corporate bond                                      481,876          499,930
                                                     ----------       ----------

                                                     $  882,825       $2,202,202
                                                     ==========       ==========

Restricted cash - long-term
    Certificates of deposit                          $       --       $2,016,364
    Savings account                                     659,618        1,034,618
                                                     ----------       ----------

                                                     $  659,618       $3,050,982
                                                     ==========       ==========


                                       7

<PAGE>

                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)
              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)





(5) ACCOUNTS RECEIVABLE RELATED TO REAL ESTATE LIMITED PARTNERSHIP

Under the terms of the Cambridge,  Massachusetts  building lease (the "Cambridge
Lease"),  the Company  accounted for $5,450,000 of its payments for a portion of
the costs of construction of the leased premises as contributions to the capital
of the Cambridge landlord in exchange for a limited partnership  interest in the
Cambridge  landlord  (the  "Partnership  Interest").  Under  the  terms  of  the
Partnership  Interest,  the  Company has the right at any time prior to February
2000 to sell the Partnership  Interest back to the other limited partners of the
landlord.  In April  1998,  the  Company  exercised  its  right to sell back the
Partnership  Interest  and  accordingly  the  contribution  to the  real  estate
partnership  has been  classified  as a current  asset at  September  30,  1998.
Subsequent to September 30, 1998, the sale of the building was finalized and the
Company received payment in November 1998.

(6) 9.0% CONVERTIBLE SUBORDINATED NOTES

On April 2, 1997, the Company issued  $50,000,000 of the 9% Notes.  As discussed
in Note 1, on May 5, 1998  noteholders  holding $48.7 million of principal value
of the 9%  Notes  tendered  such  notes in  exchange  for  Series A  convertible
preferred stock and warrants to purchase  common stock. In addition,  $2,361,850
of accrued  interest  thereon was converted  into shares of Series A convertible
preferred stock and warrants to purchase common stock. As of September 30, 1998,
there is $1.3 million principal amount of 9% Notes outstanding.  Under the terms
of the 9% Notes,  the Company  must make  semi-annual  interest  payments on the
outstanding principal balance through the maturity date of April 1, 2004. If the
9% Notes are converted  prior to April 1, 2000, the  Noteholders are entitled to
receive  accrued  interest  from the date of the most  recent  interest  payment
through the conversion date. The 9% Notes are subordinate to  substantially  all
of the Company's existing indebtedness. The 9% Notes are convertible at any time
prior to the maturity  date at a  conversion  price equal to $35.0625 per share,
subject to adjustment under certain circumstances, as defined.

Beginning April 1, 2000, the Company may redeem the 9% Notes at its option for a
4.5% premium over the original issuance price,  provided that from April 1, 2000
to March 31, 2001, the 9% Notes may not be redeemed  unless the closing price of
the common stock equals or exceeds 150% of the conversion  price for a period of
at least 20 out of 30 consecutive  trading days and the 9% Notes redeemed within
60 days after such  trading  period.  The  premium  decreases  by 1.5% each year
through March 31, 2003. Upon a change of control of the Company, as defined, the
Company  will be  required  to offer to  repurchase  the 9% Notes at 150% of the
original issuance price.

(7) NEW ACCOUNTING STANDARDS

Effective  January  1,  1998,  the  Company  adopted  SFAS  No.  130,  Reporting
Comprehensive  Income.  SFAS No. 130 requires  disclosure  of all  components of
comprehensive income on an annual and interim basis.


                                       8

<PAGE>

                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)
              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)


Comprehensive income is defined as the change in equity of a business enterprise
during a period  from  transactions  and other  events  and  circumstances  from
non-owner sources.  The Company's total comprehensive net loss for the three and
nine month periods  ended  September 30, 1998 and 1997 were the same as reported
net loss for those periods.

In July 1997,  the FASB issued SFAS No. 131,  Disclosures  About  Segments of an
Enterprise and Related Information.  SFAS No. 131 requires certain financial and
supplementary  information  to be disclosed  on an annual and interim  basis for
each reportable  segment of an enterprise.  SFAS No. 131 is effective for fiscal
years beginning after December 15, 1997. Unless  impracticable,  companies would
be required to restate  prior  period  information  upon  adoption.  The Company
believes  that the  adoption of SFAS No. 131 will not have a material  impact on
its financial results or financial position.

(8) RESTRUCTURING

Beginning in July 1997, the Company  implemented a restructuring  plan to reduce
expenditures on a phased basis over the balance of 1997 in an effort to conserve
its cash resources.  As a part of this restructuring  plan, the Company recorded
an $11,020,000  restructuring  charge in 1997 to provide for (i) the termination
of certain research programs,  (ii) the abandonment of certain leased facilities
(net of sublease income and related  disposal of fixed assets),  (iii) severance
obligations  to nearly 100  terminated  employees and (iv) the  cancellation  of
certain other contracts. During the third quarter of 1998, the Company completed
its  restructuring  plan after  moving its  corporate  headquarters  to Milford,
Massachusetts.


(9) NOTE PAYABLE TO A BANK

In December 1996, the Company  entered into a five year  $7,500,000 note payable
with a bank.  The note contains  certain  financial  covenants  that require the
Company  to  maintain  minimum  tangible  net worth and  minimum  liquidity  and
prohibits the payment of dividends. The note is payable in 59 equal installments
of $62,500  commencing  on February  1, 1997 with a balloon  payment of the then
remaining outstanding principal balance due on January 1, 2002. During 1997, the
Company's minimum liquidity had fallen below the required amount and the Company
deposited $1,758,542 as collateral under the cash pledge agreement. During 1998,
the bank withdrew the full amount of the restricted  cash and applied it against
the outstanding  balance of the note. The minimum  liquidity  requirements  were
subsequently amended to provide that if as of the fifteenth and last day of each
calendar  month  the  Company  does  not  have  minimum  liquidity  of at  least
$4,000,000, as defined, the Company will be required to immediately repay to the
bank 100% of the then outstanding balance. As of September 30, 1998,  $2,895,000
was outstanding  under the note,  which is classified as a current  liability in
the accompanying  September 30, 1998 consolidated  balance sheet.  During August
1998, the Company placed $1.6 million in escrow at the bank's request, which was
withdrawn and applied against the  outstanding  balance of the note by the bank.
Also, upon the closing of the sale of the Partnership  Interest (see Note 5) the
Company was required to pay down an additional $750,000 on the note. The Company
is also required to pay to the bank  one-half of any proceeds  received from the
sale of certain assets.  The Company intends to make payments  relating to these
items to the bank during November 1998 in the event the Loan is not purchased as
described in Note 13. On September  29, 1998,  the Company  received a waiver of
noncompliance since the Company was not in compliance with the minimum


<PAGE>

                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)
              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)

liquidity and minimum  tangible net worth  covenants  associated  with the note.
Following the sale of the  partnership  interest,  the Company was in compliance
with all such covenants.

(10) METHYLGENE, INC. LICENSING AGREEMENT

In January 1996, the Company and  MethylGene,  Inc.  ("MethylGene")  (a Canadian
company  which  is  approximately  30%  owned  by the  Company)  entered  into a
licensing agreement for the purpose of researching and developing  compounds for
the treatment of cancer and other  indications.  In May 1998, this agreement was
amended to grant  MethylGene a non-exclusive  right to use any and all antisense
chemistries  discovered  by the  Company or any of its  affiliates  for a period
commencing on May 5, 1998 and ending on the earlier of (i) the effective date of
termination  by  MethylGene  of its  contract  for  development  services  to be
provided by the  Company,  (ii) May 5, 1999,  unless  MethylGene  exercises  its
option to continue contracting for development  services,  or (iii) May 5, 2000.
As additional consideration for this non-exclusive right, MethylGene is required
to pay the Company certain milestone amounts,  as defined,  and transfer 300,000
shares of MethylGene's class B shares to the Company.  The Company has placed no
value on these  shares.  In the third  quarter  of 1998,  the  Company  recorded
$250,000 of revenue received from MethylGene.

(11) UNITS ISSUED TO PRIMEDICA CORPORATION

The Company has issued  250,000  shares of common  stock and 62,500  warrants to
purchase common stock to Primedica  Corporation  ("Primedica")  for $250 in cash
and future  services  to be  provided.  The  services  shall  commence  upon the
Company's request after (i) the Company's  securities are listed on a nationally
recognized exchange,  and (ii) the average closing price of the Company's common
stock is at least  $2.00 per share for the twenty day trading  period  preceding
the contract commencement date. In the event that the Company does not use these
services as a result of the failure to meet the contract  conditions,  Primedica
may forfeit to the Company all or part of the common stock and warrants  held by
Primedica.  The Company has recorded  these shares as issued and  outstanding at
September  30, 1998 at par value.  The Company  will record an expense for these
services as the services are provided.


<PAGE>

                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)
              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)

(12) SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION

The  accompanying   consolidated  financial  statements  include  the  following
information:



<TABLE>
<CAPTION>
                                                                                                              Cumulative    
                                                                                                              from May 25,  
                                                                      Nine Months Ended                     1989 (Inception)
                                                                        September 30,                       to September 30,
                                                                                                            
                                                                         1998              1997                 1998
<S>                                                                 <C>                 <C>                 <C>        
SUPPLEMENTAL DISCLOSURE OF NONCASH FINANCING
ACTIVITIES:

Issuance of Series A convertible preferred stock in
exchange for conversion of 9% convertible subordinated
notes payable and accrued interest                                  $51,061,850         $    --             $51,061,850
                                                                                                          
Accretion of Series A convertible preferred stock dividends         $ 1,647,000         $    --             $ 1,647,000
                                                                                                          
Issuance of common stock in exchange for conversion of                                                    
convertible subordinated notes payable                              $ 4,800,000         $    --             $ 4,800,000
                                                                                                          
Issuance of common stock in exchange for conversion of                                                    
accounts payable,  capital lease obligations and accrued                                                  
interest                                                            $ 6,434,308         $    --             $ 6,434,308
                                                                                                          
Issuance of common stock for services rendered                      $ 1,195,398         $    --             $ 1,342,272
</TABLE>

(13) SUBSEQUENT EVENT

Subsequent to September 30, 1998, Forum Capital Markets, LLC ("Forum") and Pecks
Management Partners Ltd. ("Pecks"; Forum and Pecks collectively,  the "Lender"),
affiliates  of two  members  of the  Company's  Board of  Directors,  agreed  to
purchase the Company's note payable to the bank (see Note 9). In connection with
this purchase,  the Lender will lend an additional amount to the Company as soon
as practicable so as to increase the  outstanding  principal  amount of the note
payable  to  $6,000,000.  In  addition,  the terms of the note  payable  will be
amended as follows: (i) the maturity will be extended to November 30, 2003; (ii)
the  interest  rate will be  decreased  to 8%;  (iii)  interest  will be payable
monthly in  arrears,  with the  principal  due in full at  maturity  of the note
payable;  (iv) the note payable will be convertible,  at the Lender's option, in
whole or in part, into shares of common stock of the Company;  (v) the threshold
of the minimum liquidity covenant will be reduced from $4,000,000 to $2,000,000;
and (vi) the note payable may not be prepaid,  in whole or in part,  at any time
prior to  December  1, 2000.  The other  terms of the note  payable  will remain
unchanged.  In  connection  with the  purchase of the note  payable,  Forum will
receive a fee of $400,000,  which will be reinvested by Forum by purchasing from
the  Company  common or  preferred  stock and  warrants,  and will also  receive
warrants to purchase $400,000 of shares of common stock of the Company.


                                       9


<PAGE>



Item 2. MANAGEMENT'S  DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
        OF OPERATIONS

The Company is engaged in the discovery  and  development  of genetic  medicines
based on antisense technology. The Company commenced operations in February 1990
and since that time has been  engaged  primarily  in  research  and  development
efforts,  development  of  its  manufacturing  capabilities  and  organizational
efforts,  including  recruitment  of scientific and  management  personnel,  and
raising capital.  To date, the Company has not received revenue from the sale of
biopharmaceutical  products  developed by it. In order to commercialize  its own
products, the Company will need to address a number of technological  challenges
and comply with comprehensive  regulatory requirements.  Accordingly,  it is not
possible  to predict  the amount of funds that will be required or the length of
time that will pass before the Company  receives  revenues  from sales of any of
these products.  All revenues  received by the Company to date have been derived
from  collaborative  and service  agreements,  interest  on  invested  funds and
revenues  from the custom  contract  manufacturing  of synthetic DNA and reagent
products by the Hybridon Specialty Products ("HSP") Division.

The Company has incurred  cumulative losses from inception through September 30,
1998 of  approximately  $231.6 million.  In the second half of 1997, the Company
commenced a restructuring  program that has significantly  reduced the Company's
operating expenses and cost requirements in 1998 from 1997 levels.  However, the
Company expects that its research and  development  expenses will continue to be
significant  in the fourth quarter of 1998 and in future years as it pursues its
core drug development programs and expects to continue to incur operating losses
and have significant  capital  requirements  that it will not be able to satisfy
with internally generated funds. The Company continues to explore  opportunities
to reduce  operating  expenses in an effort to conserve its cash resources.  The
number of employees has continued to decline through  attrition;  as of November
10, 1998, the Company had 49 full-time employees.

RESULTS OF OPERATIONS

The Company had total  revenues of  $1,041,000  and $668,000 in the three months
ended September 30, 1998 and 1997,  respectively,  and $3,410,000 and $3,143,000
in the nine months ended  September  30, 1998 and 1997,  respectively.  Revenues
from research and development  collaborations were $150,000 and $200,000 for the
three months ended September 30, 1998 and 1997,  respectively,  and $950,000 and
$980,000 for the nine months ended September 30, 1998 and 1997, respectively.

Product and service  revenue from the HSP Division was  $847,000 and $155,000
for the three  months  ended  September  30,  1998 and 1997,  respectively,  and
$2,353,000 and $1,231,000 for the nine months ended September 30, 1998 and 1997,
respectively. Included in the three months ended September 30, 1998 was $250,000
of  revenue  received  under  its  License   Agreement  with  MethylGene,   Inc.
("MethylGene")  for  certain  services  provided.  The  increase  in product and
service  revenue in 1998 was a result of an expansion  in the customer  base and
increasing  sales to existing  customers  and revenue  earned  under the License
Agreement with MethylGene.

Interest  income was $44,000 and $294,000  for the three months ended  September
30, 1998 and 1997,  respectively,  and $106,000 and $898,000 for the nine months
ended September 30, 1998 and 1997, respectively. The decrease in interest income
is attributable  to the decrease in cash and investments  held by the Company in
1998 as compared to 1997.


                                        10

<PAGE>

The Company had research and development  expenses of $5,201,000 and $11,339,000
for the three  months  ended  September  30,  1998 and 1997,  respectively,  and
$17,181,000  and  $37,785,000  for the nine months ended  September 30, 1998 and
1997,  respectively.  The decrease in research and development  expenses in 1998
reflects the restructuring  program that was commenced during the second half of
1997 and completed in the third quarter of 1998. The restructuring  included the
discontinuation of operations at the Company's facilities in Europe, termination
of the  clinical  development  of GEM 91 and  the  reduction  or  suspension  of
selected programs unrelated to the Company's core advanced  chemistry  antisense
drug development program, including the termination of its ribozyme program. The
restructuring resulted in significant  reductions in employee-related  expenses,
clinical  and outside  testing,  consulting,  materials  and lab  expenses.  The
Company's  facility costs in 1998 were also reduced by the income  received from
subleasing  its  underutilized  facilities.  The Company has now  relocated  its
headquarters  to its  manufacturing  facility,  which  is  located  in  Milford,
Massachusetts.

The Company had general and administrative expenses of $1,504,000 and $3,057,000
for the three  months  ended  September  30,  1998 and 1997,  respectively,  and
$5,218,000 and $9,012,000 for the nine months ended September 30, 1998 and 1997,
respectively.  The  decrease  in general  and  administrative  expenses  in 1998
resulted primarily from the Company's restructuring program initiated during the
second half of 1997 and its effect on employee-related expenses,  consulting and
net facilities costs.

The Company had interest expense of $296,000 and $1,606,000 for the three months
ended September 30, 1998 and 1997,  respectively,  and $2,880,000 and $3,223,000
for the nine  months  ended  September  30,  1998 and  1997,  respectively.  The
decrease in interest expense in 1998 is mainly attributable to the conversion of
approximately  $48.7 million of the 9% Convertible  Subordinated  Notes (the "9%
Notes"), issued in the second quarter of 1997, to Series A Convertible Preferred
Stock on May 5, 1998.

As a result of the above factors, the Company incurred losses from operations of
$5,961,000  and  $18,434,000  for the three months ended  September 30, 1998 and
1997,  respectively,  and  $21,869,000 and $49,977,000 for the nine months ended
September 30, 1998 and 1997, respectively.

The Company had  extraordinary  income of  $8,877,000  for the nine months ended
September  30, 1998  resulting  from the  conversion of the 9% Notes to Series A
Convertible  Preferred  Stock  in the  second  quarter  of 1998.  See  "Item 1 -
Financial Statements - Notes to Consolidated Condensed Financial Statements" for
a  discussion  of the  Company's  extraordinary  income.  As a  result  of  this
transaction, the Company reduced its net loss to $12,993,000 for the nine months
ended September 30, 1998.

LIQUIDITY AND CAPITAL RESOURCES

During the nine months ended  September 30, 1998, the Company's net cash used in
operating  activities  amounted to  $17,444,000.  The Company's  operating  cash
requirements  were funded primarily through the utilization of existing cash and
proceeds raised in private equity offerings conducted in the first half of 1998,
the collection of its accounts  receivable  from sales and services  provided by
the Company,  collaborative  payments  received,  the rental  payments  from its
underutilized  facilities,  and the sale of equipment. The Company believes that
its  existing  and  expected  capital  resources  will be  adequate  to fund the
Company's cash requirements into 1999.

                                       11
<PAGE>

The Company's  existing capital resources include the following amounts received
in the fourth quarter of 1998.  First,  $6,163,000  received in connection  with
relocation of the Company's  corporate  headquarters to Milford,  Massachusetts,
and the sale of the  Company's  interest in the Charles River  Building  Limited
Partnership, which owned the Company's former headquarters facility; this amount
includes a portion of the security  deposit  relating to the Company's  lease to
its former headquarters facility and the release of $660,000 in restricted cash.
Second,  $254,000  was received in  connection  with the sale in October 1998 of
certain equipment and furniture.

The  Company's  expected  capital  resources  include  committed   collaborative
research and development payments from Searle, additional amounts expected to be
advanced  under  the  Credit  Facility  (as  described   below),   research  and
development  funding  expected from  MethylGene,  Inc. and the profit margins on
anticipated sales by the HSP Division.

In  June  1998,  the  Company   relocated  its   headquarters   from  Cambridge,
Massachusetts  to its  manufacturing  facility  in Milford,  Massachusetts.  The
Cambridge facility was re-leased in September 1998 to a third party,  subject to
a sublease of a portion of the facility.  As a result,  the Company was relieved
of its substantial  lease obligations for the Cambridge  facility,  subject to a
contingent  continuing  liability  for any  defaults  which may arise  under the
sublease.

Forum  Capital  Markets,  LLC  ("Forum")  and  Pecks  Management  Partners  Ltd.
("Pecks"; Forum and Pecks collectively, the "Lender"), affiliates of two members
of the Company's  Board of  Directors,  have agreed to purchase the loan made by
Silicon Valley Bank to the Company  pursuant to the Loan and Security  Agreement
dated December 31, 1996, between the Company and Silicon Valley Bank, as amended
(the  "Loan"),   the  outstanding   principal   amount  of  which  is  currently
approximately $2.8 million.

In connection  with the purchase of the Loan, the Lender will lend an additional
amount to the Company as soon as practicable  so as to increase the  outstanding
principal amount of the Loan to $6,000,000.  In addition,  the terms of the Loan
will be amended as follows:  (i) the  maturity  will be extended to November 30,
2003;  (ii) the interest  rate will be decreased to 8%; (iii)  interest  will be
payable  monthly in arrears,  with the  principal due in full at maturity of the
Loan; (iv) the Loan will be convertible,  at the Lender's option, in whole or in
part,  into shares of common  stock,  par value $.001 per share,  of the Company
("Common Stock") at a rate equal to the mid-point  between the bid and ask price
on the date of closing of the  purchase of the Loan;  (v) the  threshold  of the
Minimum  Liquidity  covenant will be reduced from $4,000,000 to $2,000,000;  and
the Loan may not be prepaid,  in whole or in part, any time prior to December 1,
2000. The other terms of the Loan will remain unchanged.

In  connection  with the  purchase  of the  Loan,  Forum  will  receive a fee of
$400,000,  which will be  reinvested  by Forum by  purchasing  from the  Company
either (i) shares of Common  Stock or shares of  preferred  stock of the Company
and accompanying warrants on the same terms as they are sold to investors in the
Company's next equity  offering to occur after November 13, 1998 (the "Placement
Price"),  or (ii) if no equity  offering  is  consummated  prior to May 1, 1999,
160,000  shares of Common  Stock at $3.00 per share and  warrants to purchase an
additional 40,000 shares of Common Stock at $3.00 per share. In addition,  Forum
will  receive  warrants  exercisable  until  maturity  of the  Loan to  purchase
$400,000  of shares  of Common  Stock  priced at the Placement  Price or, if no
equity offering is consummated  prior to May 1, 1999, at $3.00 per share.  These
shares and warrants will be issued as soon as practicable following satisfaction
of Section 4.10 of the  Indenture  dated as of March 26, 1997,  governing the 9%
Notes.

The Company  will be  required to raise  substantial  additional  funds  through
external sources,  including through  collaborative  relationships and public or
private  financings,  to support its  operations  and,  except for  research and
development  funding  from  Searle  (which is  subject to early  termination  in
certain circumstances), revenue expected to be received from MethylGene

                                       12

<PAGE>

and sale of DNA products and reagents manufactured on a custom contract basis by
the HSP Division,  the Company has no current external sources of capital,  and,
as discussed above,  expects no product revenues for at least several years from
sales of products that it is developing.

No assurance can be given that such  additional  funds will be available to fund
the Company's operations or, if available,  that such funds will be available on
acceptable  terms. If additional funds are raised by issuing equity  securities,
further dilution to then existing  stockholders will result.  Additionally,  the
terms of any such  additional  financing  may  adversely  affect the holdings or
rights of then existing stockholders.

If  adequate  funds are not  available,  the  Company may be required to further
curtail significantly one or more of its core drug development programs,  obtain
funds  through  arrangements  with  collaborative  partners  or others  that may
require the Company to relinquish rights to certain of its technologies, product
candidates or products  which the Company would  otherwise  pursue on its own or
terminate operations.

The Company's future capital requirements will depend on many factors, including
continued  scientific  progress in its research,  drug discovery and development
programs,  the  magnitude  of these  programs,  progress  with  preclinical  and
clinical trials,  sales of DNA products and reagents to third parties by the HSP
Division and the margins on such sales, the time and costs involved in obtaining
regulatory  approvals,  the costs involved in filing,  prosecuting and enforcing
patent claims,  competing technological and market developments,  the ability of
the Company to establish  and  maintain  collaborative  academic and  commercial
research, development and marketing relationships, the ability of the Company to
obtain  third-party  financing  for  leasehold  improvements  and other  capital
expenditures  and the  costs of  manufacturing  scale-up  and  commercialization
activities and arrangements.

YEAR 2000

As has been widely publicized, many computer systems and microprocessors are not
programmed to accommodate dates beyond the year 1999. The Company's  exposure to
this year 2000 ("Y2K")  problem  comes not only from its own  internal  computer
systems and  microprocessors,  but also from the systems and  microprocessors of
its key suppliers, including utility companies and payroll services.

The Company  currently  believes  that all of its  internal  systems will be Y2K
compliant  by the end of the third  quarter of 1999.  The  Company is  currently
evaluating all of its internal computer systems and  microprocessors in light of
the Y2K problem. As part of this process, the Company is conducting an inventory
of its  automated  instruments  and  other  computerized  equipment  and will be
contacting  applicable  vendors for information  regarding Y2K  compliance.  The
Company will then upgrade or otherwise modify its internal  computer systems and
microprocessors,  to the extent necessary.  Testing of all its internal computer
systems and microprocessors  should be completed by the end of the first quarter
of 1999.  The  Company  does not expect the cost of bringing  all the  Company's
systems and microprocessors into Y2K compliance will be material.

The  Company's  Y2K  compliance   efforts  are  in  addition  to  other  planned
information technology ("IT") projects.  While these efforts have caused and may
continue to cause delays in other IT projects,  the Company does not expect that
any of these delays will have a significant  effect on the Company's business or
that any of the Company's other IT projects will be canceled or postponed to pay
for the Y2K upgrades.

                                       13

<PAGE>

With regard to potential supplier Y2K problems,  the Company has compiled a list
of its critical  suppliers,  and has sent a Y2K questionnaire to each of them in
order to permit the Company to ascertain the Y2K compliance  status of each. The
Company is awaiting  the return of these  questionnaires.  The Company  does not
know of any key supplier Y2K problems  that could have a material  effect on the
Company's  business.  If through a Y2K  questionnaire  or otherwise  the Company
becomes aware of any such problems and is not satisfied  that those problems are
being adequately  addressed,  it will take appropriate steps to find alternative
suppliers.

It has been acknowledged by governmental  authorities that Y2K problems have the
potential  to disrupt  global  economies,  that no  business  is immune from the
potentially  far-reaching  effects of Y2K problems,  and that it is difficult to
predict with certainty  what will happen after December 31, 1999.  Consequently,
it is possible  that Y2K problems  will have a material  effect on the Company's
business  even if the Company takes all  appropriate  measures to ensure that it
and its key suppliers are Y2K compliant.

It is possible that the conclusions  reached by the Company from its analysis to
date will change,  which could cause the Company's Y2K cost estimates and target
completion dates to change.

SAFE HARBOR FOR FORWARD-LOOKING STATEMENTS

This Form 1O-Q filing contains forward-looking  statements within the meaning of
the "safe harbor" provisions of the Private Securities  Litigation Reform Act of
1995. For this purpose,  any statements contained herein that are not statements
of  historical  fact  may  be  deemed  to be  forward-looking  statements.  Such
forward-looking  statements are based on management's  current  expectations and
involve  known and unknown  risks,  uncertainties,  and other  factors which may
cause the actual  results,  performance  or  achievements  of the  Company to be
materially  different  from any future  results,  performance,  or  achievements
expressed or implied by such  forward-looking  statements.  Without limiting the
foregoing,  the words "believes,"  "anticipates," "plans," "expects," "intends,"
"may," and other similar  expressions  are intended to identify  forward-looking
statements.

Factors  which may cause actual  future  results to differ from  forward-looking
statements include,  among others, the matters set forth under the heading "Item
7.  Management's  Discussion and Analysis of Financial  Condition and Results of
Operations - Certain  Factors that May Affect  Future  Results" in the Company's
Annual  Report on Form 10-K for the year  ended  December  31,  1997 (the  "1997
10-K") which information is incorporated herein by reference.

                                       14

<PAGE>

                                 HYBRIDON, INC.

                                     PART II

                                OTHER INFORMATION

                                     -------



Items 1-4 None

Item 5   OTHER INFORMATION

                  Stockholder Proposals for 1999 Annual Meeting

         As set  forth in the  Company's  Proxy  Statement  for its 1998  Annual
Meeting of Stockholders,  stockholder proposals submitted pursuant to Rule 14a-8
under the Securities and Exchange Act of 1934, as amended (the "Exchange  Act"),
for inclusion in the  Company's  proxy  material for its 1999 Annual  Meeting of
Stockholders  (the "1999 Annual  Meeting")  must be received by the Secretary of
the Company at the  principal  offices of the Company no later than  January 18,
1999.

         In addition,  the Company's  by-laws  require that the Company be given
advance notice of stockholder nominations for election to the Company's Board of
Directors  and of other  matters  (other than matters  included in the Company's
proxy statement in accordance with Rule 14a-8). The required notice must be made
in writing and  delivered or mailed by first class United  States mail,  postage
prepaid,  to the  Secretary  of the  Company  at the  principal  offices  of the
Company,  and  received not less than 60 days nor more than 90 days prior to the
1999 Annual  Meeting;  provided  however,  that if less than 70 days'  notice or
prior  public  disclosure  of the date of the meeting is given to  stockholders,
such  nomination  or other  proposal  shall have been mailed or delivered to the
Secretary no later than the close of business on the 10th day following the date
on which the notice of the meeting was mailed or such  public  disclosure  made,
whichever occurs first. The 1999 Annual Meeting is currently expected to be held
on May 10,  1999.  Assuming  that this date does not change,  in order to comply
with the time periods set forth in the  Company's  by-laws,  appropriate  notice
would need to be  provided  no earlier  than  February 9, 1999 and no later than
March 11, 1999. The advance notice provisions of the Company's by-laws supersede
the notice  requirements  contained in recent amendments to Rule 14a-4 under the
Exchange Act.


Item 6.  Exhibits and Reports on Form 8-K


    (a)  Exhibits

         27     Financial Data Schedule (EDGAR)


                                       15

<PAGE>



          99.1 Third Amendment to Loan and Security  Agreement between Hybridon,
               Inc. and Silicon Valley Bank.

          99.2 Fourth Amendment to Loan and Security Agreement between Hybridon,
               Inc. and Silicon Valley Bank.

         (b) No  Reports on Form 8-K have been  filed  during the third  quarter
ended September 30, 1998.


                                       16

<PAGE>

                                   SIGNATURES

                                     -------


    Pursuant to the  requirements  of the  Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned thereunto duly authorized.




                                           HYBRIDON, INC.


November 16, 1998                    /s/ E. Andrews Grinstead III
- - -----------------                  ----------------------------
Date                               E. Andrews Grinstead, III
                                   Chairman, President and Chief Executive
                                   Officer (Principal Executive Officer)


November 16, 1998                    /s/ Robert G Andersen
- - -----------------                  ---------------------
Date                               Robert G. Andersen
                                   Treasurer (Principal Accounting and
                                   Financial Officer)


                                       17

<PAGE>

                                 HYBRIDON, INC.

                                  EXHIBIT INDEX

                                     -------


27   Financial Data Schedule (EDGAR)

99.1 Third Amendment to Loan and Security  Agreement between Hybridon,  Inc. and
     Silicon Valley Bank.

99.2 Fourth Amendment to Loan and Security Agreement between Hybridon,  Inc. and
     Silicon Valley Bank.

                                       18




                                                                    Exhibit 99.1

                 THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT
                                     BETWEEN
                                 HYBRIDON, INC.
                                       AND
                               SILICON VALLEY BANK


         This  Third  Amendment  is  made,  effective  as of  the  18th  day  of
September,  1998 to that certain Loan and Security  Agreement  between Hybridon,
Inc., a Delaware  corporation  with a principal place of business at 155 Fortune
Boulevard, Milford,  Massachusetts (the "Borrower") and Silicon Valley Bank (the
"Bank")  dated as of December 31, 1996, as amended by consent  letter  agreement
(the "Consent  Letter")  dated  January 15, 1998 and by First  Amendment to Loan
Security  Agreement  dated  March 30, 1998 (the  "First  Amendment")  and Second
Amendment  to Loan and  Security  Agreement  dated April 16,  1998 (the  "Second
Amendment").  The Loan and  Security  Agreement  as so  amended  is  hereinafter
referred to as the "Loan Agreement."  Capitalized terms used, but not defined in
this  Third  Amendment  shall  have the  meanings  ascribed  to them in the Loan
Agreement and ancillary  documents,  instruments  and  agreements,  or if not so
defined,  shall have the  meanings  ascribed to them in the  Uniform  Commercial
Code,  or in the case of financial and  accounting  terms,  in  accordance  with
generally accepted accounting principles.

                                    RECITALS

         Pursuant  to the Loan  Agreement  and on the terms and  conditions  set
forth  therein,  on December 31, 1996,  the Bank made a secured term loan to the
Borrower in the original  face amount of $7,500,000  (the "Loan").  The Borrower
advised the Bank of its planned  offering of Units of investment in the Borrower
in January, 1998 (the "Original  Offering"),  which was consented to by the Bank
pursuant  to the  Consent  Letter  and which  was  subsequently  amended  by the
Borrower  and  consented  to by the Bank in March,  1998  pursuant  to the First
Amendment  and in  April,  1998  pursuant  to the  Second  Amendment.  The  term
"Offering" as used in this Third Amendment shall include the amended Offering or
any other equity offering or corporate  collaboration not involving indebtedness
of the Borrower.  In connection with the Borrower's  continuing  sales of equity
interests and on the terms and  conditions  set forth  herein,  the Borrower has
requested that the Bank  temporarily  waive  compliance by the Borrower with the
application of the Minimum Liquidity and Tangible Net Worth covenants.

         The Bank is willing to consent  to a  temporary  waiver of the  Minimum
Liquidity  and  Tangible  Net  Worth  covenants,  but only  upon the  terms  and
conditions set forth in this Third Amendment.

                                    AGREEMENT

         In  consideration  of  the  foregoing,  and  of  the  undertakings  and
obligations of the Borrower and the Bank set forth herein and for other good and
valuable   consideration,   receipt   and   sufficiency   of  which  are  hereby
acknowledged, the Borrower and Bank agree as follows:

     1.   The Borrower  confirms that the  outstanding  balance of principal and
          interest  on the Loan as of  September  18th,  1998 is as set forth in
          Schedule 1 hereto,  and that the  Borrower  has no  defense,  claim or
          offset which would preclude full payment of such amount.


<PAGE>


     2.   The Borrower  ratifies and confirms:  (i) its  Obligations to the Bank
          under  the  Loan  Agreement,  as  amended  hereby,  (ii)  all  of  the
          representations  and  warranties  made  by it in the  Loan  Agreement,
          except as  expressly  disclosed  to the Bank,  and (iii) that it is in
          compliance  with the  covenants and  agreements  contained in the Loan
          Agreement  except for its  failure  to  maintain  compliance  with the
          covenants  waived in the First  Amendment,  its failure to comply with
          Section 6.10(c) of the Loan Agreement, to the extent that such failure
          is nevertheless in compliance with the Intellectual  Property Security
          Agreement (the "IP Security  Agreement")  delivered by the Borrower in
          connection   with  the  Consent  Letter  (it  being  agreed  that  the
          provisions  of  Section  6.10(c)  shall be  deemed  superseded  by the
          analogous  provisions  of the IP Security  Agreement),  and except for
          Borrower's  failure to comply with the Minimum  Liquidity and Tangible
          Net Worth covenants as of June 30, 1998 and thereafter.

     3.   On  August  7,  1998,  the  Borrower   established  with  the  Bank  a
          certificate of deposit in the amount of $1,592,386 (the "Deposit"). On
          the date of this Amendment,  the Borrower authorizes the Bank to apply
          the Deposit against the outstanding  principal of the Obligations as a
          permanent reduction therein.  Such payment is in addition to any other
          regularly scheduled payments due under the Loan Agreement.

     4.   The Bank hereby waives any existing  defaults of the Minimum Liquidity
          and Tangible Net Worth  covenants  and also waives  compliance  by the
          Borrower with the Minimum  Liquidity and Tangible Net Worth  covenants
          through  September  29, 1998;  provided,  however that if the Borrower
          earlier  receives  the  cash  payment  due to it for  its  sale of its
          partnership  interest (the "CRLP  Interest") in Charles River Building
          Limited  Partnership  (such  date of  receipt,  the "CRLP Put  Date"),
          testing of such  covenants  shall begin on the following  business day
          after the CRLP Put Date rather than on September 30, 1998.

     5.   Section 6.8 of the Loan Agreement,  as previously  amended,  is hereby
          amended in its entirety to read as follows:

               "Borrower shall  maintain,  as of the last day of each quarter of
               Borrower's fiscal year, a Tangible Net Worth of not less than Six
               Million Dollars ($6,000,000.00)."

     6.   Section 6.9 of the Loan Agreement,  as previously  amended,  is hereby
          amended in its entirety to read as follows:

               "Borrower  shall  maintain  Minimum   Liquidity  (as  hereinafter
               defined) of at least $4,000,000 as of the fifteenth (15th) and as
               of the last day of the month (or the next  business day if either
               is not a business day). If the Borrower fails to maintain Minimum
               Liquidity at any test date, the Borrower shall  immediately repay
               the then outstanding  Obligations in full. "Minimum Liquidity" is
               defined as consolidated cash on hand (other than cash in which an
               entity  other  than  the  Bank  or its  assignee  has a  security
               interest, and other than the CRLP Withhold), cash equivalents and
               marketable securities,  plus 50% of the Borrower's Trade Accounts
               Receivable. "Trade Accounts Receivable" means accounts receivable
               arising from the sale of goods and services and the  licensing of
               technology in the ordinary course of the Borrower's business, but
               excluding the


                                        2

<PAGE>



          extraordinary sale of assets or other transactions not in the ordinary
          course of the Borrower's business."

     7.   Within two (2)  business  days after the CRLP Put Date,  the  Borrower
          will pay to the Bank in good and collected  funds,  in addition to any
          regularly  scheduled payments on the Obligations,  the sum of $750,000
          as an additional  payment  against the  principal of the  Obligations.
          Until  payment  of such  sum to the  Bank,  all  proceeds  of the CRLP
          interest received shall be held in trust by the Borrower for the Bank.
          The Borrower and the Bank agree that this  requirement  supersedes any
          requirement  contained in the Loan Agreement,  as previously  amended,
          relating to funds  received by the Borrower from CRLP or its partners,
          including,  without  limitation,  any requirement as to the use of the
          proceeds of such funds.

     8.   Conditioned  upon  satisfaction of the  requirements set forth in this
          paragraph,  the Bank consents to the exclusive license by the Borrower
          to OriGenix Therapeutics,  Inc., a Quebec corporation ("OriGenix"), of
          the specific patents and applications listed in Schedule 8 hereto (the
          "Patents"),  which  license shall be limited to use of the Patents for
          the  development  of treatments  for Human  Papilloma  Virus  ("HPV"),
          Hepatitis  B  Virus  ("HBV")  and up to  three  (3)  additional  viral
          indications to be agreed upon among OriGenix and the Borrower, subject
          to  the  prior  written   consent  of  the  Bank  which  will  not  be
          unreasonably withheld (collectively, the "Indications").  The Borrower
          will  retain  the  rights  to the  Patents  for other  indication  and
          molecular  targets.  The  Bank  agrees  to  deliver  to  the  Borrower
          documents  necessary  to (i)  release  its  security  interest  in the
          patents and  applications  listed in  Schedule 8 which are  designated
          with the 189 and 190 suffixes,  and (ii)  subordinate,  pursuant to an
          agreement  acceptable  to the  Borrower  and  OriGenix,  its  security
          interest to the  exclusive  licenses  to be granted to  OriGenix  with
          respect  to  all of the  other  patents  and  applications  listed  in
          Schedule 8. The  consents,  release and  subordinations  referenced in
          this paragraph are conditioned  upon (a) the Borrower  retaining a 40%
          equity ownership in OriGenix,  (b) the Borrower granting to the Bank a
          perfected,  first priority  security interest in the Borrower's entire
          ownership  interest in OriGenix  pursuant to a Pledge Agreement in the
          form of Exhibit 8, (c) OriGenix being  capitalized with a minimum cash
          equity  investment of CDN  $4,000,000  from  investors  other than the
          Borrower,  and (d) the Borrower  warranting and  representing  that no
          investor in OriGenix  owns more than five (5%) percent of the stock of
          the Borrower on a fully converted basis. The Borrower shall,  prior to
          the Bank's  delivery of the  releases  and  subordinations  referenced
          above, make a best efforts attempt to provide the Bank in writing with
          the names and  addresses of the  investors in the new entity and their
          respective ownership  interests,  a complete copy of any prospectus or
          offering  memorandum  provided to  investors,  a complete  copy of the
          business  plan for the new entity and such  other  information  as the
          Bank may reasonably require,  including evidence of the Borrower's 40%
          interest in OriGenix.

     9.   The Borrower further  acknowledges  that all reasonable  out-of-pocket
          costs  and  expenses  of the  Bank  in  connection  with  negotiation,
          documentation and  administration  of this Third Amendment,  including
          reasonable fees of attorneys  engaged to represent the Bank,  shall be
          borne by the Borrower.


                                        3

<PAGE>

     10.  The Borrower  acknowledges  and  confirms  that to the extent that the
          Borrower  may have any claims,  offsets,  counterclaims,  or defenses,
          asserted or unasserted, the Borrower, for itself, and on behalf of its
          successors,   assigns,  parents,  subsidiaries,   agents,  affiliates,
          predecessors,  employees, officers, directors, executors and heirs, as
          applicable  (collectively,  the  "Borrower  Affiliates")  releases and
          forever discharges the Bank, its subsidiaries,  affiliates, employees,
          officers,  directors, agents, successors and assigns, both present and
          former  (collectively,  the "Bank Affiliates") of and from any and all
          manner  of  claims,  offsets,  counterclaims,   defenses,  action  and
          actions,  cause and causes of  action,  suits,  debts,  controversies,
          damages,  judgments,  executions, and demands whatsoever,  asserted or
          unasserted,  in law or in equity,  which  against  the Bank and/or the
          Bank  Affiliates,  they or the  Borrower  Affiliates  ever  had to and
          including  the date  hereof,  upon or by reason of any matter,  cause,
          causes or thing whatsoever,  in connection with the Loan and/or any of
          the  transactions   and  matters  related  thereto,   except  for  the
          obligations of the Bank in such documents,  instruments and agreements
          to be performed after the date of this Third  Amendment.  The Borrower
          shall  indemnify,  defend and hold the Bank  harmless  of and from any
          claim  brought or  threatened  against the Bank by the Borrower or any
          other  person  (as  well as  from  attorneys'  fees  and  expenses  in
          connection therewith) on account of the Loan Agreement,  the Note, the
          Consent Letter, the Intellectual  Property Security Agreement,  Pledge
          Agreement,  Intercreditor  Agreement,  the First Amendment, the Second
          Amendment, this Third Amendment and any other document,  instrument or
          agreement   given  in  connection   with  the  Loan  and  any  of  the
          transactions  and  matters  related  thereto  (each  of  which  may be
          defended, compromised,  settled or pursued by the Bank with counsel of
          the Bank's election reasonably acceptable to the Borrower,  but at the
          expense of the Borrower),  except in the case of the Bank's failure to
          comply  with  its  obligations  hereunder  or  thereunder,  its  gross
          negligence or willful misconduct.

     11.  The Borrower  acknowledges and agrees that the Bank's agreement herein
          to  temporarily  waive  compliance  with  the  Minimum  Liquidity  and
          Tangible Net Worth  covenants  shall not create a course of dealing or
          conduct  and that the Bank has not agreed to waive any other  covenant
          or agreement with the Borrower or to waive compliance with the Minimum
          Liquidity and Tangible Net Worth  covenants other than for the limited
          time period set forth in this Third Amendment.

     12.  To the extent possible,  this Third Amendment shall be construed to be
          consistent with the provisions of the Loan Agreement;  however, to the
          extent that the provisions of this Third Amendment  expressly conflict
          with  or  contradict  the  provisions  of  the  Loan  Agreement,   the
          provisions of this Third Amendment shall be deemed to control.

     13.  This Third  Amendment  represents  the entire  agreement  between  the
          parties with respect to the modifications  contained herein, and shall
          be  construed  in  accordance  with  the laws of the  Commonwealth  of
          Massachusetts as an agreement under seal. The Borrower has voluntarily
          entered into this Third  Amendment  without  coercion or duress of any
          kind and has been or has had the opportunity to have been  represented
          by legal counsel of their choosing.


                                        4

<PAGE>

         WITNESS OUR hands and seals on this 18th day of September, 1998.

HYBRIDON, INC.                                           SILICON VALLEY BANK

By:  /s/Robert G. Andersen                      By: /s/ Sean Lynden
     ---------------------                          -------------------------

                                        5

<PAGE>

                                  SCHEDULE 1 TO
                 THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT
                                     BETWEEN
                               SILICON VALLEY BANK
                               AND HYBRIDON, INC.


Principal Balance as of September 15, 1998                    $4,487,175.22
Interest outstanding at September 15, 1998                        23,768.61


                                        6




                                                                    Exhibit 99.2

                 FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT
                                     BETWEEN
                                 HYBRIDON, INC.
                                       AND
                               SILICON VALLEY BANK


         This  Fourth  Amendment  is  made,  effective  as of  the  29th  day of
September,  1998, to that certain Loan and Security  Agreement between Hybridon,
Inc., a Delaware  corporation  with a principal place of business at 155 Fortune
Boulevard, Milford,  Massachusetts (the "Borrower") and Silicon Valley Bank (the
"Bank")  dated as of December 31, 1996, as amended by consent  letter  agreement
(the "Consent Letter") dated January 15, 1998 and by First Amendment to Loan and
Security  Agreement  dated  March  30,  1998  (the  "First  Amendment"),  Second
Amendment  to Loan and  Security  Agreement  dated April 16,  1998 (the  "Second
Amendment") and Third  Amendment to Loan and Security  Agreement dated September
18, 1998 (the "Third Amendment").  The Loan and Security Agreement as so amended
is hereinafter referred to as the "Loan Agreement".  Capitalized terms used, but
not defined in this Fourth Amendment shall have the meanings ascribed to them in
the Loan Agreement and ancillary  documents,  instruments and agreements,  or if
not so  defined,  shall  have  the  meanings  ascribed  to them  in the  Uniform
Commercial Code, or in the case of financial and accounting terms, in accordance
with generally accepted accounting principles.

                                    RECITALS

         Pursuant to the Third  Amendment,  the  Borrower and the Bank agreed to
temporarily  waive  compliance  by the Borrower  with the Tangible Net Worth and
Minimum  Liquidity   covenants  (as  amended)  through  September  29,  1998  to
accommodate  the sale by the Borrower of the CRLP  Interest.  The closing of the
sale of the CRLP Interest has not occurred and the Borrower has  requested  that
the Bank agree to extend the waiver of  covenant  compliance  until  October 31,
1998.

         The Bank is willing to  consent to extend the  temporary  waiver of the
Minimum Liquidity and Tangible Net Worth covenants,  but only upon the terms and
conditions set forth in this Fourth Amendment.

                                    AGREEMENT

         In  consideration  of  the  foregoing,  and  of  the  undertakings  and
obligations of the Borrower and the Bank set forth herein and for other good and
valuable   consideration,   receipt   and   sufficiency   of  which  are  hereby
acknowledged, the Borrower and Bank agree as follows:

     1.   The Borrower  confirms that the  outstanding  balance of principal and
          interest  on the  Loan  as of  October  15,  1998 is as set  forth  in
          Schedule 1 hereto,  and that the  Borrower  has no  defense,  claim or
          offset which would preclude full payment of such amount.

     2.   The Borrower  ratifies and confirms:  (i) its  Obligations to the Bank
          under  the  Loan  Agreement,  as  amended  hereby,  (ii)  all  of  the
          representations  and  warranties  made  by it in the  Loan  Agreement,
          except as  expressly  disclosed  to the Bank,  and (iii) that it is in
          compliance with


<PAGE>

          the covenants and agreements  contained in the Loan  Agreement  except
          for its failure to maintain  compliance  with the covenants  waived in
          the First Amendment, its failure to comply with Section 6.10(c) of the
          Loan  Agreement,  to the extent that such failure is  nevertheless  in
          compliance with the Intellectual  Property Security Agreement (the "IP
          Security Agreement")  delivered by the Borrower in connection with the
          Consent Letter (it being agreed that the provisions of Section 6.10(c)
          shall be  deemed  superseded  by the  analogous  provisions  of the IP
          Security Agreement),  and except for Borrower's failure to comply with
          the Minimum  Liquidity and Tangible Net Worth covenants as of June 30,
          1998 and thereafter.

     3.   The Bank hereby waives any existing  defaults in the Minimum Liquidity
          and Tangible Net Worth  covenants  and also waives  compliance  by the
          Borrower with the Minimum  Liquidity and Tangible Net Worth  covenants
          through October 31, 1998; provided however,  that if the CRLP Put Date
          is earlier  than  October 31, 1998,  testing of such  covenants  shall
          begin on the  following  business  day after the CRLP Put Date  rather
          than on October 31, 1998.  Within two (2) business days after the CRLP
          Put  Date,  the  Borrower  will pay to the Bank in good and  collected
          funds,  in  addition  to  any  regularly  scheduled  payments  on  the
          Obligations,  the sum of $750,000 as an additional payment against the
          principal of the Obligations.

     4.   In  consideration  of the  Bank's  agreement  to extend  its waiver of
          compliance with the Tangible Net Worth and Liquidity covenants through
          October 31, 1998, the Borrower shall pay to the Bank a forbearance fee
          in the amount of $25,000 in  addition  to any other  amounts  due with
          respect to the Obligations.  If the CRLP Put Date is after October 15,
          1998, the  forbearance fee shall increase by $1,000 per day commencing
          October 16, 1998, but in no event more than an additional $16,000. The
          $25,000  installment of the  forbearance fee is due and payable on the
          date of this Fourth Amendment,  and any and all incremental  increases
          thereto shall be due and payable no later than October 31, 1998.

     5.   The Borrower further  acknowledges  that all reasonable  out-of-pocket
          costs  and  expenses  of  he  Bank  in  connection  with  negotiation,
          documentation and  administration of this Fourth Amendment,  including
          reasonable fees of attorneys  engaged to represent the Bank,  shall be
          borne by the Borrower.

     6.   The Borrower  acknowledges  and  confirms  that to the extent that the
          Borrower  may have any claims,  offsets,  counterclaims,  or defenses,
          asserted or unasserted, the Borrower, for itself, and on behalf of its
          successors,   assigns,  parents,  subsidiaries,   agents,  affiliates,
          predecessors,  employees, officers, directors, executors and heirs, as
          applicable  (collectively,  the  "Borrower  Affiliates")  releases and
          forever discharges the Bank, its subsidiaries,  affiliates, employees,
          officers,  directors, agents, successors and assigns, both present and
          former  (collectively,  the "Bank Affiliates") of and from any and all
          manner  of  claims,  offsets,  counterclaims,   defenses,  action  and
          actions,  cause and causes of  action,  suits,  debts,  controversies,
          damages,  judgments,  executions, and demands whatsoever,  asserted or
          unasserted,  in law or in equity,  which  against  the Bank and/or the
          Bank  Affiliates,  they or the  Borrower  Affiliates  ever  had to and
          including  the date  hereof,  upon or by reason of any matter,  cause,
          causes or thing whatsoever,  in connection with the Loan and/or any of
          the  transactions   and  matters  related  thereto,   except  for  the
          obligations of the Bank in such documents,  instruments and agreements
          to be performed after the date of this Fourth Amendment.  The Borrower
          shall indemnify, defend


                                        2

<PAGE>


          and hold the Bank harmless of and from any claim brought or threatened
          against the Bank by the  Borrower or any other person (as well as from
          attorneys'  fees and expenses in  connection  therewith) on account of
          the Loan  Agreement,  the Note, the Consent Letter,  the  Intellectual
          Property   Security   Agreement,   Pledge   Agreement,   Intercreditor
          Agreement,  the  First  Amendment,  the  Second  Amendment,  the Third
          Amendment, this Fourth Amendment and any other document, instrument or
          agreement   given  in  connection   with  the  Loan  and  any  of  the
          transactions  and  matters  related  thereto  (each  of  which  may be
          defended, compromised,  settled or pursued by the Bank with counsel of
          the Bank's election reasonably acceptable to the Borrower,  but at the
          expense of the Borrower),  except in the case of the Bank's failure to
          comply  with  its  obligations  hereunder  or  thereunder,  its  gross
          negligence or willful misconduct.

     7.   The Borrower  acknowledges and agrees that the Bank's agreement herein
          to  temporarily  waive  compliance  with  the  Minimum  Liquidity  and
          Tangible Net Worth  covenants  shall not create a course of dealing or
          conduct  and that the Bank has not agreed to waive any other  covenant
          or agreement with the Borrower or to waive compliance with the Minimum
          Liquidity and Tangible Net Worth  covenants other than for the limited
          time period set forth in this Fourth Amendment.

     8.   To the extent possible, this Fourth Amendment shall be construed to be
          consistent with the provisions of the Loan Agreement;  however, to the
          extent that the provisions of this Fourth Amendment expressly conflict
          with  or  contradict  the  provisions  of  the  Loan  Agreement,   the
          provisions of this Fourth Amendment shall be deemed to control.

     9.   This Fourth  Amendment  represents  the entire  agreement  between the
          parties with respect to the modifications  contained herein, and shall
          be  construed  in  accordance  with  the laws of the  Commonwealth  of
          Massachusetts as an agreement under seal. The Borrower has voluntarily
          entered into this Fourth  Amendment  without coercion or duress of any
          kind and has been or has had the opportunity to have been  represented
          by legal counsel of its choosing.


         WITNESS  OUR  hands  and  seals  on this  30th  day of  October,  1998,
effective as of September 29, 1998.



WITNESS:                                            SILICON VALLEY BANK

/s/ C. Wade                                        By: /s/ Sean Lynden
- - -----------------------------                          ------------------------

                                                       HYBRIDON, INC.

/s/ Cheryl M. Northrup                             By: /s/ E. Andrews Grinstead
- - -----------------------------                          ------------------------


                                        3

<PAGE>


                                  SCHEDULE 1 TO
                 FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT
                                     BETWEEN
                               SILICON VALLEY BANK
                               AND HYBRIDON, INC.

Principal Balance as of October 15, 1998                      $2,832,289.22
Interest outstanding at October 15, 1998                          14,613.83


                                        4


<TABLE> <S> <C>


<ARTICLE>                     5
<LEGEND>
          HYBRIDON, INC. AND SUBSIDIARIES
          (A DEVELOPMENT STAGE COMPANY)
</LEGEND>

       
<S>                                       <C>
<PERIOD-TYPE>                            9-MOS
<FISCAL-YEAR-END>                                               DEC-31-1998 
<PERIOD-START>                                                  JAN-01-1998 
<PERIOD-END>                                                    SEP-30-1998 
<CASH>                                                              882,825 
<SECURITIES>                                                              0 
<RECEIVABLES>                                                       825,668 
<ALLOWANCES>                                                              0 
<INVENTORY>                                                               0 
<CURRENT-ASSETS>                                                  7,606,865 
<PP&E>                                                           22,925,187 
<DEPRECIATION>                                                   13,972,070 
<TOTAL-ASSETS>                                                   18,398,562 
<CURRENT-LIABILITIES>                                            10,422,268 
<BONDS>                                                           1,879,017 
                                                     0 
                                                           6,248 
<COMMON>                                                             15,255 
<OTHER-SE>                                                        6,075,774 
<TOTAL-LIABILITY-AND-EQUITY>                                     18,398,562 
<SALES>                                                           2,353,435 
<TOTAL-REVENUES>                                                  3,409,807 
<CGS>                                                                     0 
<TOTAL-COSTS>                                                    22,398,791 
<OTHER-EXPENSES>                                                          0 
<LOSS-PROVISION>                                                          0 
<INTEREST-EXPENSE>                                                2,880,307 
<INCOME-PRETAX>                                                 (21,869,291)
<INCOME-TAX>                                                              0 
<INCOME-CONTINUING>                                             (21,869,291)
<DISCONTINUED>                                                            0 
<EXTRAORDINARY>                                                   8,876,685 
<CHANGES>                                                                 0 
<NET-INCOME>                                                    (12,992,606)
<EPS-PRIMARY>                                                         (1.22)
<EPS-DILUTED>                                                         (1.22)
                                                                
                                                       

</TABLE>


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