HYBRIDON INC
DEF 14A, 1999-04-30
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  SCHEDULE 14A
                                 (Rule 14a-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION
                Proxy Statement Pursuant to Section 14(a) of the
                         Securities Exchange Act of 1934

     Filed by the registrant  |X|
     Filed by a party other than the registrant |_|
     Check the appropriate box:
     |_|    Preliminary proxy statement    |_| Confidential, for Use of the Com-
                                               mission Only (as permitted by
                                               Rule 14a-6(e)(2)) 

     |X| Definitive proxy statement 
     |_| Definitive  additional materials 
     |_| Soliciting material pursuant to Rule 14a-11(c) or Rule 14a-12

                                 HYBRIDON, INC.
                                 --------------
                (Name of Registrant as Specified in Its Charter)


                                 --------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of filing fee (Check the appropriate box):
   |X|    No Fee required.
   |_|    Fee computed on table below per Exchange Act Rules 14a-6(i)(4) 
          and 0-11.
   (1)    Title of each class of securities to which transaction applies:

   (2)    Aggregate number of securities to which transaction applies:

   (3)    Per unit price or other underlying value of transaction computed 
          pursuant to Exchange Act Rule 0-11:

   (4)    Proposed maximum aggregate value of transaction:

   (5)    Total fee paid:

   |_|    Fee paid previously with preliminary materials.

   |_|    Check box if any part of the fee is offset as provided by Exchange
          Act  Rule  0-11(a)(2)  and  identify  the  filing  for  which  the
          offsetting fee was paid  previously.  Identify the previous filing
          by registration  statement number, or the form or schedule and the
          date of its filing.

   (1)    Amount previously paid:

   (2)    Form, schedule or registration statement no.:

   (3)    Filing party:

   (4)    Date filed:


<PAGE>

                                 HYBRIDON, INC.

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                             TO BE HELD JUNE 8, 1999

         NOTICE IS HEREBY GIVEN that the 1999 annual meeting of the stockholders
(the  "Annual  Meeting")  of  Hybridon,   Inc.,  a  Delaware   corporation  (the
"Company"),  will be held on Tuesday, June 8, 1999 at 10:00 A.M. at the Radisson
Hotel, 11 Beaver Street, Milford, Massachusetts,  for the purpose of considering
and voting upon the following matters:

          1.   To elect three Class I Directors  to the Board of  Directors  for
               the ensuing three years;

          2.   To approve an amendment to the 1997 Stock Incentive Plan;

          3.   To approve an amendment to the 1995 Director Stock Option Plan;

          4.   To ratify the  selection of Arthur  Andersen  LLP as  independent
               auditors of the Company for the current year; and

          5.   To transact  such other  business as may properly come before the
               Annual Meeting or any adjournment thereof.

         The Board of Directors  has no  knowledge  of any other  business to be
transacted at the Annual Meeting.

         The Board of Directors has fixed the close of business on Friday, April
16,  1999 as the  record  date (the  "Record  Date")  for the  determination  of
stockholders  entitled to receive notice of and to vote at the Annual Meeting or
any adjournment thereof.

         A copy of the  Company's  1998  Annual  Report to  Stockholders,  which
contains consolidated  financial statements and other information of interest to
stockholders,  is being mailed with this Notice and the enclosed Proxy Statement
on or about May 8, 1999 to all stockholders of record on the Record Date.

                                          By order of the Board of Directors,



                                          Cheryl M. Northrup, Secretary

Milford, Massachusetts
April 30, 1999

WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING,  PLEASE PROMPTLY COMPLETE,  DATE,
SIGN AND RETURN THE ENCLOSED PROXY IN THE ACCOMPANYING ENVELOPE. NO POSTAGE NEED
BE AFFIXED IF THE PROXY IS MAILED IN THE UNITED STATES.


<PAGE>

                                 HYBRIDON, INC.
                                155 FORTUNE BLVD.
                          MILFORD, MASSACHUSETTS 01757


                                 PROXY STATEMENT


                       FOR ANNUAL MEETING OF STOCKHOLDERS

                             TO BE HELD JUNE 8, 1999

         This proxy statement (the "Proxy  Statement") is furnished by the board
of directors (the "Board of Directors" or "Board") of Hybridon, Inc. ("Hybridon"
or  the  "Company"),   in  connection  with  the  Company's  annual  meeting  of
stockholders (the "Annual Meeting") to be held on Tuesday, June 8, 1999 at 10:00
A.M. at the Radisson  Hotel,  11 Beaver Street,  Milford,  Massachusetts  or any
adjournment thereof.

         All proxies will be voted in accordance  with the  instructions  of the
stockholder.  If no choice is  specified,  the proxies will be voted in favor of
the matters set forth in the  accompanying  Notice of Meeting.  Any proxy may be
revoked by a  stockholder  at any time  before its  exercise  by  delivery  of a
written revocation or a subsequently dated proxy to the Secretary of the Company
or by voting in person at the Annual  Meeting.  Attendance at the Annual Meeting
will not  itself  be  deemed  to revoke a proxy  unless  the  stockholder  gives
affirmative notice at the Annual Meeting that the stockholder  intends to revoke
the proxy and vote in person.

         On April 16, 1999, the record date for  determination  of  stockholders
entitled to vote at the Annual Meeting,  there were  outstanding and entitled to
vote an aggregate of 15,606,825 shares of Common Stock of the Company, $.001 par
value per share (the "Common  Stock").  Each share entitles the record holder to
one vote on each of the matters to be voted upon at the Annual Meeting.

         THE NOTICE OF THE ANNUAL MEETING,  THIS PROXY  STATEMENT,  THE ENCLOSED
PROXY AND THE COMPANY'S 1998 ANNUAL REPORT TO  STOCKHOLDERS  ARE BEING MAILED TO
STOCKHOLDERS  ON OR ABOUT MAY 8, 1999. THE COMPANY WILL, UPON WRITTEN REQUEST OF
ANY STOCKHOLDER, FURNISH WITHOUT CHARGE A COPY OF ITS ANNUAL REPORT ON FORM 10-K
FOR THE YEAR ENDED  DECEMBER 31, 1998, AS FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION,  WITHOUT EXHIBITS.  PLEASE ADDRESS ALL SUCH REQUESTS TO THE COMPANY,
ATTENTION  OF INVESTOR  RELATIONS,  155 FORTUNE  BLVD.,  MILFORD,  MASSACHUSETTS
01757.  EXHIBITS  WILL BE  PROVIDED  UPON  WRITTEN  REQUEST  AND  PAYMENT  OF AN
APPROPRIATE PROCESSING FEE.


<PAGE>

                                 VOTES REQUIRED

         The  holders of a majority  of the shares of Common  Stock,  issued and
outstanding and entitled to vote at the Annual Meeting shall constitute a quorum
for the  transaction of business at the Annual  Meeting.  Shares of Common Stock
present in person or represented by proxy (including  shares which abstain or do
not vote with respect to one or more of the matters  presented  for  stockholder
approval) will be counted for purposes of determining whether a quorum exists at
the Annual Meeting.

         The affirmative vote of the holders of a plurality of the votes cast by
the  stockholders  entitled to vote at the Annual  Meeting is  required  for the
election of directors.  The affirmative vote of the holders of a majority of the
shares of Common Stock present or  represented by proxy and voting on the matter
is required  for the  approval of the  amendments  to the  Company's  1997 Stock
Incentive  Plan  and the  Company's  1995  Director  Stock  Option  Plan and the
ratification of the selection of the Company's independent auditors.

         Shares which abstain from voting as to a particular  matter, and shares
held in "street  name" by brokers or nominees who indicate on their proxies that
they do not have discretionary  authority to vote such shares as to a particular
matter,  will not be counted as votes in favor of such matter, and will also not
be  counted  as  votes  cast  or  shares  voting  on such  matter.  Accordingly,
abstentions and "broker non-votes" will have no effect on the voting on a matter
that requires the affirmative vote of a certain  percentage of the votes cast or
shares voting on a matter.

         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

         The following table sets forth certain information as of April 16, 1999
with  respect  to the  beneficial  ownership  of shares of Common  Stock by each
person known to the Company to own beneficially  more than 5% of the outstanding
shares of Common Stock, assuming conversion of all convertible debt or preferred
stock and exercise of all warrants and stock  options by such person and only by
such person.

<TABLE>
<CAPTION>

                                                                     Amount and Nature
                                                                of Beneficial Ownership(1) ++
Name and Address of                                            Number of               Percent of
Beneficial Owner                                                Shares                   Class
- ----------------                                                ------                   -----

5% STOCKHOLDERS

<S>                                                            <C>                      <C>
Pecks Management Partners Ltd..................                8,252,339(2)             34.59%
One Rockefeller Plaza
New York, New York  10022

Forum Capital Markets LLC......................                4,555,517(3)             23.33%
53 Forest Ave.
Old Greenwich, CT  06870

General Motors Employees.......................                3,660,314(4)              19.0%
Domestic Group Trust
c/o Pecks Management Partners Ltd.
One Rockefeller Plaza
New York, New York  10020

Guardian Life Insurance........................                3,090,922(5)             16.53%
Company of America
201 Park Avenue South, 7A
New York, New York  10003


                                        2

<PAGE>

Intercity Holdings Ltd.........................                2,216,666(6)             13.87%
c/o Cuson Milner House
18 Parliment Street
Hamilton, Bermuda

Abdelah Bin Mahfouz............................                2,216,666(7)             13.87%
c/o SEDCO
P.O. Box 4384
Jeddah 21491
Saudi Arabia

Delaware State Employees.......................                2,439,227(8)             13.52%
Retirement Fund
c/o Pecks Management Partners Ltd.
One Rockefeller Plaza
New York, New York  10020

Youssef El-Zein................................                1,748,722(9)             10.35%
28 Avenue de Messine
75008 Paris, France

Nasser Menhall.................................               1,726,734(10)             10.22%
28 Avenue de Messine
75008 Paris, France

Pillar Investment Limited......................               1,617,173(11)              9.65%
28 Avenue de Messine
75008 Paris, France

Yahia M.A. Bin Laden...........................               1,373,977(12)              8.67%
2 rue Charles Bonnet
1206 Geneva, Switzerland

Nicris Limited.................................               1,360,644(13)              8.59%
c/o Magnin Dunand & Associes
2 rue Charles Bonnet
1206 Geneva, Switzerland

Lincoln National Life Insurance Co.............               1,215,223(14)              7.22%
c/o Lynch & Mayer
520 Madison Avenue
New York, New York  10022

Faisal Finance Switzerland SA..................               1,043,112(15)              6.58%
84 Ave Louis Casi
1216 Geneva, Switzerland

Finova Technology Finance Inc..................                896,875 (16)              5.56%
10 Waterside Drive
Farmington, CT  06032

Declaration of Trust for the...................                 850,430(17)              5.17%
Defined Benefit Plan of ICI 
American Holdings, Inc.
c/o Pecks Management Partners Ltd.
One Rockfeller Plaza
New York, New York  10022

</TABLE>

- ------------------------------------

++       Amount of ownership does not include dividends  issuable by the Company
         at April 1, 1999 of 3.25 shares of Series A Convertible Preferred Stock
         for each 100 shares of Series A Convertible Preferred Stock owned.

(1)      The number of shares  beneficially owned by each director and executive
         officer is determined  under rules  promulgated  by the  Securities and
         Exchange Commission,  and the information is not necessarily indicative
         of  beneficial  ownership  for any other  purpose.  Under  such  rules,
         beneficial ownership includes any shares as to which the individual has
         sole or shared  voting  power or  investment  power and also any shares
         which the  individual  has the right to  acquire  within 60 days  after
         April 16, 1999 through the exercise of any stock option or other right.
         The inclusion  herein of such shares,  however,  does not constitute an
         admission that the named stockholder is a direct or indirect beneficial
         owner of such shares. Unless otherwise indicated, each person or entity
         named in the  table has sole  voting  power  and  investment  power (or
         shares such power with his or her spouse) with respect to all shares of
         capital stock listed as owned by such person or entity.

(2)      Includes  247,339 shares of Series A Convertible  Preferred Stock owned
         by six  investment  advisory  clients  of Pecks,  which  clients  would
         receive dividends and the proceeds from the sale of such shares.  Three
         of


                                        3


<PAGE>

         these clients are Delaware State  Employees  Retirement  Fund,  General
         Motors Employees  Domestic Group Trust and Declaration of Trust for the
         Defined  Benefit Plan of ICI American  Holdings,  Inc.  These shares of
         Series A Convertible  Preferred  Stock are  convertible  into 5,819,742
         shares  of Common  Stock of the  Company.  This  amount  also  includes
         762,425  shares  issuable  upon the  exercise  of Class A warrants  and
         420,172  shares  issuable upon the exercise of Class D warrants held in
         the  aggregate by the  foregoing  entities.  This number also  includes
         1,250,000   shares  issuable  upon  conversion  of  a  portion  of  the
         $6,000,000  bank loan to the Company  owned by certain of the foregoing
         entities.

(3)      Includes (a) 328,677 shares issuable upon exercise of Class B warrants,
         (b) 280,517 shares issuable upon the exercise of Class C warrants,  (c)
         408,112 shares issuable upon exercise of Class A warrants,  (d) 588,235
         shares issuable upon exercise of other warrants,  (e) 1,250,000  shares
         issuable upon conversion of Forum's portion of the $6,000,000 bank loan
         to the Company,  and (f) 1,063,717  shares  issuable upon conversion of
         45,208 shares of Series A Convertible Preferred Stock owned by Forum.

(4)      Includes  110,581 shares of Series A Convertible  Preferred Stock which
         are convertible  into 2,601,906  shares of Common Stock of the Company.
         This amount also includes  492,783 shares issuable upon the exercise of
         Class A warrants  and 565,625  shares  issuable  upon  conversion  of a
         portion  of the  $6,000,000  bank  loan to the  Company  owned  by this
         entity.

(5)      Includes  105,634 shares of Series A Convertible  Preferred Stock which
         are convertible  into 2,485,506  shares of Common Stock of the Company.
         This amount also includes  353,316 shares issuable upon the exercise of
         Class A warrants and 252,100 shares issuable upon the exercise of Class
         D warrants.

(6)      Includes  375,000 shares issuable upon the exercise of Class B warrants
         held by Intercity Holdings Ltd.

(7)      Includes  1,841,666 shares held by Intercity  Holdings Ltd. and 375,000
         shares  issuable  upon  exercise of Class B warrants  held by Intercity
         Holdings. Mr. Mahfouz, a controlling  stockholder of Intercity Holdings
         Ltd., may be considered a beneficial  owner of the shares  beneficially
         owned by such entity.

(8)      Includes  71,221 shares of Series A Convertible  Preferred  Stock which
         are convertible  into 1,675,788  shares of Common Stock of the Company.
         This amount also includes  137,918 shares issuable upon the exercise of
         Class A warrants,  270,271 shares issuable upon the exercise of Class D
         warrants and 355,250 shares  issuable upon conversion of portion of the
         $6,000,000 bank loan to the Company owned by this entity.

(9)      Includes (a) 82,183 shares  issuable upon the exercise of warrants held
         by Mr.  El-Zein,  (b) 366 shares issuable upon the exercise of warrants
         held by Pillar Associated, (c) 20,000 shares issuable upon the exercise
         of warrants held by Pillar S.A.,  (d) 20,000  shares  issuable upon the
         exercise  of  warrants  held by  Pillar  S.A.R.L.,  (e)  37,500  shares
         issuable  upon  the  exercise  of  Class  C  warrants  held  by  Pillar
         Investment Limited,  (f) 473,598 issuable upon the exercise of advisory
         warrants held by Pillar Investment Limited, (g) 638,032 shares issuable
         upon the  exercise  of  placement  warrants  held by Pillar  Investment
         Limited,  (h) 5,243 shares issuable upon the exercise of other warrants
         held by Pillar  Investment  Limited,  (i) 462,800 shares held by Pillar
         Investment Limited,  and (j) 9,000 shares issuable upon the exercise of
         stock options held by Mr. El-Zein.  Mr. El-Zein, an affiliate of Pillar
         Associated,   Pillar  S.A.,  Pillar  S.A.R.L.,  and  Pillar  Investment
         Limited,   may  be   considered  a  beneficial   owner  of  the  shares
         beneficially owned by such entities.

(10)     Includes (a) 60,195 shares  issuable upon the exercise of warrants held
         by Mr.  Menhall,  (b) 366 shares issuable upon the exercise of warrants
         held by Pillar Associated, (c) 20,000 shares issuable upon the exercise
         of warrants held by Pillar S.A.,  (d) 20,000  shares  issuable upon the
         exercise  of  warrants  held by  Pillar  S.A.R.L.,  (e)  37,500  shares
         issuable  upon  the  exercise  of  Class  C  warrants  held  by  Pillar
         Investment Limited,  (f) 473,598 issuable upon the exercise of advisory
         warrants held by Pillar Investment Limited, (g) 638,032 shares issuable
         upon the  exercise  of  placement  warrants  held by Pillar  Investment
         Limited,  (h) 5,243 shares issuable upon the exercise of other warrants
         held by Pillar  Investment  Limited,  (i) 462,800 shares held by Pillar
         Investment Limited,  and (j) 9,000 shares issuable upon the exercise of
         stock options


                                        4


<PAGE>

         held by Mr. Menhall.  Mr. Menhall,  an affiliate of Pillar  Associated,
         Pillar S.A.,  Pillar S.A.R.L.,  and Pillar Investment  Limited,  may be
         considered a beneficial owner of the shares  beneficially owned by such
         entities.

(11)     Includes  (a)  37,500  shares  issuable  upon the  exercise  of Class C
         warrants held by Pillar Investment  Limited,  (c) 473,598 issuable upon
         the exercise of advisory  warrants held by Pillar  Investment  Limited,
         (c) 638,032  shares  issuable  upon the exercise of placement  warrants
         held by Pillar Investment  Limited,  and (d) 5,243 shares issuable upon
         the exercise of other warrants held by Pillar Investment Limited.

(12)     Includes  1,125,880  shares held by Nicris  Limited and 234,764  shares
         issuable upon the exercise of Class B warrants held by Nicris  Limited.
         Mr. Bin Laden, a controlling stockholder of Nicris, may be considered a
         beneficial owner of the shares beneficially owned by such entity.

(13)     Includes  234,764 shares issuable upon the exercise of Class B warrants
         held by Nicris Limited.

(14)     Includes  41,531 shares of Series A Convertible  Preferred  Stock which
         are  convertible  into  977,200  shares of Common Stock of the Company.
         This amount also includes  238,023 shares issuable upon the exercise of
         Class A warrants.

(15)     Includes  233,026 shares issuable upon the exercise of Class B warrants
         held by Faisal Finance Switzerland SA.

(16)     Includes  259,375 shares issuable upon the exercise of Class C warrants
         held by Finova Technology Finance Inc.

(17)     Includes  25,713 shares of Series A Convertible  Preferred  Stock which
         are  convertible  into  605,012  shares of Common Stock of the Company.
         This amount also includes  42,153 shares  issuable upon the exercise of
         Class A warrants,  74,265 shares  issuable upon the exercise of Class D
         warrants and 129,000  shares  issuable upon  conversion of a portion of
         the $6,000,000 bank loan to the Company owned by this entity.


         The following table sets forth certain information as of April 16, 1999
with respect to the beneficial  ownership of shares of Common Stock and Series A
Preferred Stock by (i) the directors of the Company and (ii) the Chief Executive
Officer  and  other  Named  Executive  Officers,  and (iii)  the  directors  and
executive  officers  of the  Company  as a  group,  assuming  conversion  of all
convertible  debt or  preferred  stock and  exercise of all  warrants  and stock
options by such person and only by such person.

<TABLE>
<CAPTION>
                                                                                                Series A
                                                       Common Stock                         Preferred Stock ++
                                                       ------------                         ------------------
                                           Amount and Nature of   Percent of       Amount and Nature of   Percent of
Name of Beneficial Owner                   Beneficial Ownership     Class          Beneficial Ownership     Class
DIRECTORS
- ---------
<S>                                              <C>              <C>                    <C>              <C>   
Arthur W. Berry.........................         8,252,339(2)     34.59%                 247,339(3)       38.57%
Harold W. Purkey........................         4,555,517(4)     23.33%                  45,208(5)       7.05%
Youssef El-Zein.........................        1,748,722 (6)     10.35%                         0        0
Nasser Menhall..........................        1,726,734 (7)     10.22%                         0        0
E. Andrews Grinstead III ...............          628,176 (8)     3.88%                          0        0
Sudhir Agrawal..........................          469,116 (9)     2.92%                          0        0
Paul Z. Zamecnik........................           24,430 (10)    2.07%                          0        0
James B. Wyngaarden.....................           67,100 (11)     *                             0        0
Camille A. Chebeir......................           25,000          *                             0        0
H.F. Powell.............................                0          0                             0        0
All directors and executive officers as a
group (10 persons)......................       16,139,595(12)     53.28%                   292,547        45.62%

</TABLE>

- ------------------------------------


                                        5

<PAGE>

++       Amount of ownership does not include dividends  issuable by the Company
         at April 1, 1999 of 3.25 shares of Series A Convertible Preferred Stock
         for each 100 shares of Series A Convertible Preferred Stock owned.

*        Less than 1%.

(1)      The number of shares  beneficially owned by each director and executive
         officer is determined  under rules  promulgated  by the  Securities and
         Exchange Commission,  and the information is not necessarily indicative
         of  beneficial  ownership  for any other  purpose.  Under  such  rules,
         beneficial ownership includes any shares as to which the individual has
         sole or shared  voting  power or  investment  power and also any shares
         which the  individual  has the right to  acquire  within 60 days  after
         April 16, 1999 through the exercise of any stock option or other right.
         The inclusion  herein of such shares,  however,  does not constitute an
         admission that the named stockholder is a direct or indirect beneficial
         owner of such shares. Unless otherwise indicated, each person or entity
         named in the  table has sole  voting  power  and  investment  power (or
         shares such power with his or her spouse) with respect to all shares of
         capital stock listed as owned by such person or entity.

(2)      Includes  247,339 shares of Series A Convertible  Preferred Stock owned
         by six  investment  advisory  clients  of Pecks,  which  clients  would
         receive dividends and the proceeds from the sale of such shares.  Three
         of these clients are Delaware State Employees  Retirement Fund, General
         Motors Employees  Domestic Group Trust and Declaration of Trust for the
         Defined  Benefit Plan of ICI American  Holdings,  Inc.  These shares of
         Series A Convertible  Preferred  Stock are  convertible  into 5,819,742
         shares  of Common  Stock of the  Company.  This  amount  also  includes
         762,425  shares  issuable  upon the  exercise  of Class A warrants  and
         420,172  shares  issuable upon the exercise of Class D warrants held in
         the  aggregate by the  foregoing  entities.  This number also  includes
         1,250,000   shares  issuable  upon  conversion  of  a  portion  of  the
         $6,000,000  bank loan to the Company  owned by certain of the foregoing
         entities.  Mr.  Berry,  a  principal  of  Pecks,  may be  considered  a
         beneficial  owner of the  shares  owned  by such  entities.  Mr.  Berry
         disclaims beneficial ownership of these shares.

(3)      Consists  of 247,339  shares of Series A  Convertible  Preferred  Stock
         owned by six investment  advisory clients of Pecks, which clients would
         receive dividends and the proceeds from the sale of such shares.  Three
         of these clients are Delaware State Employees  Retirement Fund, General
         Motors  Employees  Domestic  Group Trust and  Declaration  of Trust for
         Defined  Benefit Plan of ICI American  Holdings,  Inc.  These shares of
         Series A Convertible  Preferred  Stock are  convertible  into 5,819,742
         shares of Common Stock of the Company. Mr. Berry, a principal of Pecks,
         may be  considered  a  beneficial  owner  of the  shares  owned by such
         entities. Mr. Berry disclaims beneficial ownership of these shares.

(4)      Includes  (a) 636,259  shares of Common  Stock  owned by Forum  Capital
         Markets LLC, (b) 328,677  shares  issuable upon the exercise of Class B
         warrants owned by Forum,  (c) 280,517 shares issuable upon the exercise
         of Class C warrants owned by Forum,  (d) 408,112  shares  issuable upon
         the exercise of Class A warrants owned by Forum,  (e) 1,250,000  shares
         issuable upon conversion of Forum's portion of the $6,000,000 bank loan
         to the Company and (f) 1,067,717  shares  issuable  upon  conversion of
         45,208 shares of Series A Convertible  Preferred  Stock owned by Forum.
         Mr. Purkey, an affiliate of Forum, may be considered a beneficial owner
         of the shares beneficially owned by such entity.

(5)      Consists of 45,208 shares of Series A Convertible Preferred Stock owned
         by Forum.  Mr.  Purkey,  an  affiliate  of Forum,  may be  considered a
         beneficial owner of the shares beneficially owned by Forum.

(6)      Includes (a) 82,183 shares  issuable upon the exercise of warrants held
         by Mr.  El-Zein,  (b) 366 shares issuable upon the exercise of warrants
         held by Pillar Associated, (c) 20,000 shares issuable upon the exercise
         of warrants held by Pillar S.A.,  (d) 20,000  shares  issuable upon the
         exercise  of  warrants  held by  Pillar  S.A.R.L.,  (e)  37,500  shares
         issuable  upon  the  exercise  of  Class  C  warrants  held  by  Pillar
         Investment Limited,  (f) 473,598 issuable upon the exercise of advisory
         warrants held by Pillar Investment Limited, (g) 638,032 shares issuable
         upon the  exercise  of  placement  warrants  held by Pillar  Investment
         Limited,  (h) 5,243 shares issuable upon the exercise of other warrants
         held by Pillar  Investment  Limited,  (i) 462,800 shares held by Pillar
         Investment Limited,  and (j) 9,000 shares issuable upon the exercise of
         stock options


                                        6


<PAGE>

         held by Mr. El-Zein.  Mr. El-Zein,  an affiliate of Pillar  Associated,
         Pillar S.A.,  Pillar S.A.R.L.,  and Pillar Investment  Limited,  may be
         considered a beneficial owner of the shares  beneficially owned by such
         entities.

(7)      Includes (a) 60,195 shares  issuable upon the exercise of warrants held
         by Mr.  Menhall,  (b) 366 shares issuable upon the exercise of warrants
         held by Pillar Associated, (c) 20,000 shares issuable upon the exercise
         of warrants held by Pillar S.A.,  (d) 20,000  shares  issuable upon the
         exercise  of  warrants  held by  Pillar  S.A.R.L.,  (e)  37,500  shares
         issuable  upon  the  exercise  of  Class  C  warrants  held  by  Pillar
         Investment Limited,  (f) 473,598 issuable upon the exercise of advisory
         warrants held by Pillar Investment Limited, (g) 638,032 shares issuable
         upon the  exercise  of  placement  warrants  held by Pillar  Investment
         Limited,  (h) 5,243 shares issuable upon the exercise of other warrants
         held by Pillar  Investment  Limited,  (i) 462,800 shares held by Pillar
         Investment Limited,  and (j) 9,000 shares issuable upon the exercise of
         stock options held by Mr. Menhall. Mr. Menhall,  an affiliate of Pillar
         Associated,   Pillar  S.A.,  Pillar  S.A.R.L.,  and  Pillar  Investment
         Limited,   may  be   considered  a  beneficial   owner  of  the  shares
         beneficially owned by such entities.

(8)      Includes 580,596 shares subject to outstanding  stock options which are
         exercisable within the 60-day period following April 16, 1999.

(9)      Includes 451,356 shares subject to outstanding  stock options which are
         exercisable within the 60-day period following April 16, 1999.

(10)     Includes (a) 32,000 shares subject to  outstanding  stock options which
         are exercisable  within the 60-day period  following April 16, 1999 and
         (b) 31,250 shares issuable upon the exercise of Class C warrants.

(11)     Includes (a) 62,000 shares subject to  outstanding  stock options which
         are exercisable  within the 60-day period  following April 16, 1999 and
         (b) 700 shares held by Mr. Wyngaarden's children.

(12)     Securities owned by Pillar  Associated,  Pillar S.A.,  Pillar S.A.R.L.
         and Pillar  Investment  Limited are included  only once,  although such
         amounts were included above for Messrs. El-Zein and Menhall.

                       PROPOSAL 1 -- ELECTION OF DIRECTORS

         The Board of  Directors,  consisting  of ten  directors is divided into
three classes.  Each class of directors,  is elected for a staggered  three-year
term.  During 1998, the Board of Directors elected Arthur W. Berry and Harold L.
Purkey as Class I directors,  whose terms shall expire at the Annual Meeting. In
1999,  Mohamed A.  El-Khereiji  resigned as a Class II director and the Board of
Directors elected Camille A. Chebeir, whose term shall expire at the 2000 Annual
Meeting  of   Stockholders,   to  the  vacancy  created  by  Mr.   El-Khereiji's
resignation.  In addition, in 1999 the Board of Directors elected H.F. Powell as
a Class III  director,  whose term shall  expire at the 2001  Annual  Meeting of
Stockholders.

         At the  Annual  Meeting,  three  directors  will be  elected as Class I
directors,   each  whose  term  will  expire  at  the  2002  Annual  Meeting  of
Stockholders  and until his  successor  is  elected  and  qualified.  All of the
Company's existing Class I directors, Nasser Menhall, Arthur W. Berry and Harold
L. Purkey,  have been  nominated for  re-election  at the Annual  Meeting.  Each
nominee has indicated his  willingness  to serve,  if elected;  however,  if any
nominee  should be unable to serve,  the person  acting under the proxy may vote
the proxy for a  substitute  nominee.  The Board of  Directors  has no reason to
believe that any of the nominees will be unable to serve if elected.

         The  shares  in the  enclosed  proxy  will be  voted  FOR  the  persons
nominated, unless a vote is withheld for any or all of the individual nominees.

         For each  member of the  Board of  Directors,  including  those who are
nominees for election as Class I Directors,  there follows  information given by
each concerning his name, age (as of April 30, 1999), length of


                                        7


<PAGE>

service  as a  director  of  the  Company,  principal  occupation  and  business
experience for at least the past five years and the names of other publicly held
companies of which he serves as a director.

<TABLE>
<CAPTION>


                                                                                PRINCIPAL OCCUPATION, OTHER
                                                                            BUSINESS EXPERIENCE DURING PAST FIVE
                                              DIRECTOR                                     YEARS
              NAME                      AGE             SINCE                     AND OTHER DIRECTORSHIPS
              ----                      ---             -----                     -----------------------

Nominees for Terms Expiring in 2002 (Class I Directors)

<S>                                     <C>             <C>                   <C>
Nasser Menhall..................        43              1992                  Member of the Board of Directors and Chief
                                                                              Executive Officer of the WorldCare Group, a
                                                                              teleradiology company, since 1993; President
                                                                              of Pillar Limited, a private investment and
                                                                              management consulting firm, since 1990;
                                                                              President of Biomedical Associates, a private
                                                                              investment firm, since 1990.

Arthur W. Berry.................        57              1998                  Chairman and Managing Partner of Pecks
                                                                              Management Partners Ltd., since 1990; Vice
                                                                              President and Co-Manager of the Alliance
                                                                              Convertible Securities Group and President of
                                                                              the Alliance Convertible Fund from 1985 to
                                                                              1990; prior to joining Alliance, Vice President
                                                                              and Head of Special Funds Section and
                                                                              Manager of the Harris Convertible Fund at
                                                                              Harris Bank and Senior Portfolio Manager in
                                                                              the bank's Individual Investment Management
                                                                              Group.  Member of the Board of Directors of
                                                                              Intellicorp, Inc.

Harold L. Purkey................        55              1998                  President of Forum Capital Markets LLC;
                                                                              Senior Managing Director of Convertible
                                                                              Securities at Smith Barney Shearson from 1990
                                                                              to 1994; Senior Executive Vice President of
                                                                              Drexel Burnham Lambert from 1982 to 1989.
                                                                              Member of the Board of Directors of
                                                                              Richardson Electronics Limited.

Directors Whose Terms Expire in 2000 (Class II Directors)


Camille A. Chebeir..............        60              1999                  President of SEDCO Services, Inc., a company
                                                                              which manages investments for a private Saudi
                                                                              Arabian family group, since 1995, and a
                                                                              member of the Board of Directors of various
                                                                              entities in which SEDCO invests; Managing
                                                                              Director of MetroWest, a Florida real estate
                                                                              development company since 1995; Executive
                                                                              Vice President of the New York branch of
                                                                              National Commercial Bank from 1989 to 1992
                                                                              and Vice President of Operations from 1983 to
                                                                              1989; formerly President of the Arab Bankers
                                                                              Association of America.


                                        8

<PAGE>


James B. Wyngaarden, M.D........        74              1990                  Foreign Secretary of the National Academy of
                                                                              Sciences and the Institute of Medicine of the
                                                                              National Academy of Sciences from 1990 to
                                                                              1994; Council member of the Human Genome
                                                                              Organization from 1990 to 1993 and Director
                                                                              from 1990 to 1991; Director of the National
                                                                              Institute of Health from 1982 to 1989;
                                                                              Member of the Board of Directors of Human
                                                                              Genome Sciences, Inc. and Magainin
                                                                              Pharmaceuticals, Inc.; Elected Vice Chairman
                                                                              of the Board of Directors of the Company in
                                                                              February 1997.

Paul C. Zamecnik, M.D...........        86              1990                  Principal Scientist at the Worcester Foundation
                                                                              for Biomedical Research, Inc. from 1979 to
                                                                              1996. Collis P. Huntington Professor of
                                                                              Oncologic Medicine Emeritus at the Harvard
                                                                              Medical School from 1956 to 1979; Emeritus since
                                                                              1979.  Senior Scientist and Honorary Physician
                                                                              at The Massachusetts General Hospital since 1998.


Directors Whose Terms Expire in 2001 (Class III Directors)

Sudhir Agrawal, D.Phil..........        45              1993                  Senior Vice President of the Company since
                                                                              March 1994; Chief Scientific Officer of the
                                                                              Company since January 1993; Vice President
                                                                              of Discovery of the Company from December
                                                                              1991 to January 1993; Principal Research
                                                                              Scientist of the Company from February 1990
                                                                              to January 1993.

Youssef El-Zein.................        50              1992                  Executive Officer of Pillar S.A., a private
                                                                              investment and management consulting firm,
                                                                              since 1991; Chairman of the WorldCare Group
                                                                              since 1993; Member of the Board of Directors
                                                                              of Pillar Investment Limited, a private
                                                                              investment and management consulting firm,
                                                                              since 1991; Elected Vice Chairman of the
                                                                              Board of Directors of the Company in
                                                                              February 1997.

E. Andrews Grinstead, III.......        53              1991                 Chairman  of the Board and Chief  Executive
                                                                             Officer   of  the   Company   since   1991;
                                                                             President of the Company since 1993; Member
                                                                             of  the  Board  of   Directors  of  Pharmos
                                                                             Corporation     and    Meridian     Medical
                                                                             Technologies.

H.F. Powell.....................        66              1999                  Chief Financial Officer and Executive Vice
                                                                              President of Nabisco, Inc. from 1994 to 1996
                                                                              and held various executive offices with Nabisco
                                                                              affiliates from 1982 to 1994; Senior Vice
                                                                              President and Chief Financial Officer of
                                                                              Standard Brands, Inc. from 1980 to 1981 and
                                                                              held various executive offices with Standard
                                                                              Brands affiliates from 1974  to 1980.
</TABLE>

         For information relating to shares of Common Stock owned by each of the
directors, see "Security Ownership of Certain Beneficial Owners and Management."


                                        9

<PAGE>

Certain Transactions

         Since January 1, 1998, Hybridon has entered into or has been engaged in
the following  transactions with the following  Hybridon directors and officers,
stockholders who  beneficially own more than 5% of the outstanding  Common Stock
of Hybridon ("5%  Stockholders"),  and affiliates or immediate family members of
those directors, officers and 5% Stockholders.


Transactions with Pillar S.A. and Certain of Its Affiliates

         Hybridon has entered into certain transactions with Pillar S.A., Pillar
Investments  and Charles River Building  Limited  Partnership,  the entity which
owned  the  Company's  former  headquarters  in  Cambridge,  Massachusetts  (the
"Cambridge  Landlord").  Pillar S.A. and Pillar  Investments  are  affiliates of
Messrs.  El-Zein and Menhall, two directors of Hybridon.  The Cambridge Landlord
is an affiliate of Messrs. El-Zein and Menhall and Mohamed El-Khereiji, a former
director of  Hybridon.  The  following is a summary of those  transactions  that
relate to Hybridon's 1998 fiscal year.

         In 1998,  Hybridon  was a party to a consulting  agreement  with Pillar
S.A.  dated  as of March 1,  1994  (the  "1994  Pillar  Consulting  Agreement"),
pursuant to which Pillar S.A.  provided  Hybridon  with  financial  advisory and
managerial services in connection with Hybridon's overseas operations, including
support services in connection with contracts and agreements. Under the terms of
the 1994 Pillar Consulting Agreement,  Hybridon paid Pillar S.A. consulting fees
of $60,000 per month and $23,000 per month for overhead  costs,  and  reimbursed
certain authorized  out-of-pocket expenses. The 1994 Pillar Consulting Agreement
expired on February 28, 1998.

         On July 8, 1995,  Hybridon  entered into an additional  agreement  with
Pillar S.A. (the "Pillar Europe Agreement") pursuant to which Pillar S.A. agreed
for a period of two years to provide to Hybridon  certain  consulting,  advisory
and related services (in addition to the services to be provided pursuant to the
1994 Pillar  Consulting  Agreement) and serve as Hybridon's  exclusive  agent in
connection   with  potential   corporate   partnerships   in  Europe  and  as  a
non-exclusive  placement agent of Hybridon in connection with private placements
of securities of Hybridon.  On November 1, 1995, the Pillar Europe Agreement was
amended  to provide  that (1) Pillar  S.A.  would  cease to serve as  Hybridon's
executive agent in connection with potential  corporate  partnerships in Europe,
but would continue to serve as a  non-exclusive  agent in that  connection,  (2)
Pillar S.A. would receive a retainer of $26,470 per month for the balance of the
term of the Pillar  Europe  Agreement,  (3) the fees  provided for in the Pillar
Europe  Agreement  would only be  payable  to Pillar  S.A.  in  connection  with
potential  collaborations  with any  French  pharmaceutical  company  with which
Hybridon  engaged in  discussions  during the 12-month  period ended November 1,
1995 as a result of  introductions  by  Pillar  S.A.,  and (4) any  compensation
payable to Pillar S.A. in  connection  with its  services  with respect to other
corporate  collaborations or any placements of securities would be negotiated on
a  case-by-case  basis and would be subject to the  approval of the  independent
members of the Board of  Directors  of  Hybridon.  The Pillar  Europe  Agreement
expired on April 1, 1997.

         In 1998,  Hybridon  paid Pillar  Investments  an  aggregate of $300,000
under  these  agreements,  in the form of  150,000  shares of  Common  Stock and
warrants to purchase  37,500  shares of Common  Stock,  at an exercise  price of
$2.40 per share, subject to adjustment, in lieu of cash.

         Hybridon  has  retained  Pillar   Investments  as  placement  agent  in
connection  with the private  placements  of  securities of Hybridon in offshore
transactions in reliance upon an exemption from registration  under Regulation S
(the "Regulation S Offerings")  promulgated under the Securities Act of 1933, as
amended (the "Securities Act").  Pillar Investments  received fees consisting of
(1)  9%  of  the  gross   proceeds  of  each   Regulation  S  Offering,   (2)  a
non-accountable  expense allowance equal to 4% of those gross proceeds,  (3) the
right to  purchase,  for nominal  consideration,  warrants  to purchase  473,598
shares of Common  Stock,  at an  exercise  price of $2.40 per share,  subject to
adjustment  (the  "Pillar  Warrants"),  (4) the right to  purchase,  for nominal
consideration,  warrants to  purchase a number of shares of the Common  Stock of
Hybridon equal to 10% of the aggregate number of shares of Common Stock


                                       10


<PAGE>

sold by  Hybridon  for  which  Pillar  Investments  acted  as  placement  agent,
exercisable at 120% of the relevant Common Stock offering price, for a period of
five years  (resulting,  as of the date hereof, in the right to receive warrants
to purchase 638,032 shares at $2.40 per share, subject to adjustment), and (5) a
consulting/restructuring  fee of  $960,000  payable in Common  Stock of Hybridon
valued at the  market  price and  payable  in three  equal  installments  as net
proceeds  of  $25,000,000,  $30,000,000  and  $35,000,000  are  received  in the
aggregate  from  private  placements  effected by Hybridon in 1998 to the extent
contemplated  by the  Consent  and Waiver  dated as of January 12, 1998 given by
certain  beneficial  holders  of the  9%  Notes,  or  otherwise  to  the  extent
contemplated  by the  Placement  Agency  Agreement  between  Hybridon and Pillar
Investments,  subject to  Hybridon's  receipt of a fairness  opinion with regard
thereto.  In no event may Pillar Investments  receive  compensation in excess of
the level that was approved by the holders of the 9% Notes.  Pillar  Investments
has  received  $1,635,400  in cash  pursuant  to these  arrangements  and Pillar
Warrants to purchase 1,111,630 shares of Common Stock.

         In addition,  in connection  with the Regulation S Offerings,  Hybridon
and Pillar Investments have entered into an advisory agreement dated May 5, 1998
pursuant to which Pillar Investments acts as Hybridon's  non-exclusive financial
advisor.  This  agreement  requires  that  Hybridon  pay an  affiliate of Pillar
Investments a monthly retainer of $5,000 (with a minimum engagement of 24 months
beginning  on May 5, 1998),  and further  provides  that Pillar  Investments  is
entitled  to receive  (1)  out-of-pocket  expenses,  (2)  subject to  Hybridon's
receipt of a fairness  opinion with respect  thereto,  300,000  shares of Common
Stock in connection with Pillar  Investments'  efforts in assisting  Hybridon in
restructuring its balance sheet, and (3) certain cash and equity success fees in
the event  Pillar  Investments  assists  Hybridon  in  connection  with  certain
financial and strategic  transactions.  As of April 16, 1999, Hybridon issued to
Pillar  Investments  the  stipulated  300,000  shares of Common Stock.  Hybridon
received a fairness opinion in connection with that issuance.


Transactions with the Cambridge Landlord

         From February 4, 1997 to September 16, 1998,  Hybridon was a party to a
lease with the Cambridge  Landlord for its Cambridge  facilities (the "Cambridge
Lease") . The Cambridge  Lease  originally  provided for an annual rent equal to
$30 per square foot on a triple-net  basis  (meaning that the tenant pays taxes,
insurance, and operating costs) for the first five years, $33 per square foot on
a  triple-net  basis for the next five  years and the  greater of $30 per square
foot on a triple-net basis or the then-market  value of leased property for each
of the five-year  renewal  terms.  In  connection  with  Hybridon's  election to
acquire an interest in the Cambridge  Landlord,  as described  below, the annual
rent due under the Cambridge Lease was increased for the first five years of the
lease term to $38 per square  foot on a  triple-net  basis,  for the second five
years to $42 per square foot on a triple-net  basis and for the third five years
to $47 per square foot on a triple-net basis.

         On July 1, 1996, Hybridon elected to fund approximately $5.5 million of
the costs (primarily relating to tenant improvements) of the construction of the
leased premises through  contributions to the capital of the Cambridge  Landlord
in exchange for a limited  partnership  interest in the Cambridge  Landlord (the
"Partnership  Interest").  The  Partnership  Interest  entitled  Hybridon  to an
approximately  32% interest in the Cambridge  Landlord.  Hybridon had the right,
for a period  of three  years  ending  February  2000,  to sell the  Partnership
Interest back to certain limited partners of the Cambridge  Landlord for a price
equal to the greater of (1) the aggregate cash  contribution made by Hybridon to
the Cambridge Landlord or (2) the fair market value of the Partnership  Interest
at the time.

         In 1997,  Hybridon  had on deposit with Bank fur  Vermogensanlagen  und
Handel  ("BVH") the amount of  $1,034,618.  In November,  1997,  German  banking
authorities imposed a moratorium on BVH and closed BVH for business. Pursuant to
an agreement  dated November 28, 1997, the Cambridge  Landlord  agreed to assume
the risk for the BVH  deposit  and to pay to  Hybridon  the  amount of $75,000 a
month after each rent payment under the Cambridge Lease was made until such time
as $1,000,000 had been paid to Hybridon or the BVH deposit was released.


                                       11


<PAGE>

         In June 1998,  Hybridon  relocated its headquarters  from the Cambridge
facility to its facility in Milford,  Massachusetts.  The Cambridge facility was
re-leased in September 1998 to a third party, subject to a sublease of a portion
of the facility.  As a result,  Hybridon  terminated the Cambridge Lease and was
relieved of its substantial lease obligations under the Cambridge Lease, subject
to a contingent  continuing  liability for any sublessee  defaults.  Further, in
November 1998  Hybridon  completed the sale of its  Partnership  Interest.  As a
result of these  transactions,  Hybridon received  $6,163,000 from the Cambridge
Landlord,  which included payment for the Partnership Interest,  the return of a
portion of the security  deposit required under the Cambridge Lease, and payment
in full of the BVH deposit.


Transactions with Forum Capital Markets LLC and Pecks Management Partners Ltd.

         In 1998,  Hybridon  entered into certain  transactions  with Forum,  an
affiliate of Mr. Purkey who is a director of Hybridon,  and entities  advised by
Pecks  Management  Partners  Ltd.  Mr.  Berry is a principal of Pecks and also a
director of Hybridon.

         Hybridon  retained Forum as a placement agent of Hybridon in connection
with  Hybridon's  1998  Regulation D offering of Series A Convertible  Preferred
Stock and Class D warrants in the U.S.  Forum received as  compensation  for its
services as  placement  agent with regard to the  Regulation  D offering and its
assistance  with an exchange  offer made by the Company to the holders of its 9%
Convertible Subordinated Notes, 597,699 shares of Common Stock and warrants (the
"1998 Forum  Warrants") to purchase prior to May 4, 2003 an aggregate of 609,194
shares of Common Stock  exercisable at $2.40 per share,  in each case subject to
adjustment.  In  addition,  in  consideration  of the  agreements  made by Forum
consenting  to the  Regulation D offering  and waiving  certain  obligations  of
Hybridon to Forum, Hybridon agreed to amend Forum's warrant dated as of April 2,
1997,  to purchase up to 71,301  shares of Common  Stock of Hybridon  (the "1997
Forum  Warrant"),  to change the exercise  price to $4.25 per share,  subject to
adjustment,  and increase the number of shares of Common Stock  purchasable upon
exercise to 588,235, in each case subject to adjustment,  and to provide that it
may not be  exercised  until May 5, 1999 and the  transactions  contemplated  by
those  private  placements  and by the  exchange  offer  will  not  trigger  any
anti-dilution  adjustments  to its  exercise  price or the  number  of shares of
Common Stock purchasable upon exercise.

         In  November  1998,  Forum  and  entities  advised  by Pecks  purchased
Hybridon's  bank  loan.  In  connection  with  the  purchase  of the  loan,  the
purchasing  entities advanced an additional amount to Hybridon so as to increase
the outstanding  principal  amount of the loan to $6,000,000.  In addition,  the
purchasing entities agreed to amend the terms of the loan. This principal amount
of the loan and accrued but unpaid interest thereon is convertible,  in whole or
in part, at the lenders' option into Common Stock at a conversion price of $2.40
per share.

         In connection  with the purchase of the loan,  Forum will receive a fee
of $400,000,  which Forum will reinvest by purchasing  from Hybridon  either (1)
shares of Common Stock or shares of Preferred Stock of Hybridon and accompanying
warrants  on the same terms as they are sold to  investors  in  Hybridon's  next
equity offering to occur after November 13, 1998 (the "Placement Price"), or (2)
if no equity  offering is  consummated  prior to May 1, 1999,  160,000 shares of
Common  Stock and  warrants to purchase an  additional  40,000  shares of Common
Stock at $3.00 per share. In addition,  Forum will receive warrants  exercisable
until maturity of the Loan to purchase $400,000 of shares of Common Stock priced
at the Placement Price or, if no equity offering is consummated  prior to May 1,
1999, at $3.00 per share.

         Hybridon   maintains  an  investment   account  at  Forest   Investment
Management LLC, an affiliate of Forum and Mr. Purkey.


                                       12


<PAGE>

Other Transactions

         In March 1999, the Company  entered into consulting  arrangements  with
each of Mr. Powell, Dr. Zamecnik and Dr. Wyngaarden  pursuant to which each such
person will act as a  consultant  to the Company for a two-year  period and will
receive a consulting fee of $20,000 per year for general consulting services. In
addition, each person will receive a consulting fee of $1,500 per day of on-site
consulting  services provided by such person at the Company's  corporate offices
(or at an  alternative  site agreed upon by the  parties),  and at the Company's
prior  request.   Additional  fees  for  special  projects  will  be  negotiated
separately  between  the  parties.  Each of Mr.  Powell,  Dr.  Zamecnik  and Dr.
Wyngaarden is also entitled to receive options to purchase 150,000 shares of the
Company's  Common  Stock at $2.00  per  share;  such  options  will  vest over a
two-year period.

         Certain  persons and  entities  (the  "Rightsholders"),  including  Dr.
Zamecnik,  Pillar S.A., Pillar Limited,  Intercity  Holdings,  Mr. Bin Laden and
Nicris,  are entitled to certain rights with respect to the  registration  under
the  Securities   Act  of  certain  shares  of  Hybridon's   Common  Stock  (the
"Registrable  Shares"),  including  shares of Common  Stock that may be acquired
pursuant to the exercise of options or warrants,  under the terms of  agreements
among  Hybridon  and the  Rightsholders  (the  "Registration  Agreements").  The
Registration Agreements generally provide that in the event Hybridon proposes to
register  any of its  securities  under the  Securities  Act at any  time,  with
certain  exceptions,  the Rightsholders,  including Pillar S.A., Pillar Limited,
Intercity Holdings,  Mr. Bin Laden and Nicris, but excluding,  among others, Dr.
Zamecnik,  have the additional  right under certain  Registration  Agreements to
require  Hybridon  to  prepare  and  file  registration   statements  under  the
Securities  Act,  if  Rightsholders   holding   specified   percentages  of  the
Registrable Shares so request,  and Hybridon is required to use its best efforts
to effect that registration, subject to certain conditions and limitations.

         Hybridon  believes that the terms of the  transactions  described above
were no less favorable than Hybridon could have obtained from unaffiliated third
parties.


Section 16(a) Beneficial Ownership Reporting Compliance

         Section 16(a) of the  Securities  Exchange Act of 1934, as amended (the
"Exchange  Act"),  requires  each  director  and each  executive  officer of the
Company  and each  holder  of more  than 10% of the  outstanding  shares  of the
Company's Common Stock to file with the Securities and Exchange  Commission (the
"Commission") an initial statement of ownership and, as required, a statement of
changes in ownership of equity  securities  of the Company.  Each such person is
required by  Commission  regulations  to furnish the Company with a copy of each
Section 16(a) statement it files with respect to the Company.

         Based solely on its review of copies of filed Section 16(a) statements,
the Company  believes that during 1998 all  directors and executive  officers of
the Company and all holders of more than 10% of the outstanding shares of Common
Stock  complied  with the  requirements  of Section  16(a) of the Exchange  Act,
except that each of the following  persons  failed to timely file a Statement of
Changes of Beneficial  Ownership of Securities on Form 4 in connection  with one
transaction  effected  during 1998: Mr. E. Andrews  Grinstead III and Dr. Sudhir
Agrawal.


Board of Directors and Committee Annual Meetings

         The  Board of  Directors  held ten  meetings  (including  by  telephone
conference and by written consent) in 1998. All directors  attended at least 75%
of the meetings of the Board of Directors  and of the  committees  on which they
served.

         The  Board of  Directors  has an Audit  Committee,  which  reviews  the
results  and scope of the audit and other  services  provided  by the  Company's
independent public  accountants.  The Audit Committee held two meetings in 1998.
The  members  of the Audit  Committee  are  Messrs.  Menhall  and Purkey and Dr.
Wyngaarden.


                                       13


<PAGE>

         The Board of Directors has a Compensation Committee,  which reviews the
salaries,  benefits and any other compensation of the Company's senior executive
officers,  to make  recommendations  to the Board of  Directors  with respect to
these matters and to administer the Company's  stock option plans.  In 1998, the
Compensation  Committee  held two  meetings.  The  members  of the  Compensation
Committee are Messrs. Berry and El-Zein and Dr. Wyngaarden.

         The Board of Directors does not have a standing  nominating  committee.
The function  customarily  performed by a nominating  committee is undertaken by
the Board of Directors,  as a whole,  which  entertains  nominations made by any
Board  member.  In the past,  the Board of  Directors  has  established  special
nominating  committees to identify and propose potential new Board members,  and
the Board may do so again in the future.



                COMPENSATION OF EXECUTIVE OFFICERS AND DIRECTORS

Compensation of Executive Officers

Summary Compensation Table

         The following  table sets forth the  compensation  for the fiscal years
ended December 31, 1998 ("fiscal 1998"), December 31, 1997 and December 31, 1996
for those persons,  the Company's Chief Executive  Officer and Chief  Scientific
Officer,  who were serving as Executive  Officers at December 31, 1998 and whose
total  annual  salary  and bonus  exceeded  $100,000  in fiscal  1998 (the Chief
Executive  Officer and Chief Scientific  Officer are hereinafter  referred to as
the "Named Executive Officers"):

                           SUMMARY COMPENSATION TABLE

<TABLE>
<CAPTION>
                                                                                                                      LONG-TERM
                                                                                                                     COMPENSATION
                                                                   ANNUAL COMPENSATION                                  AWARDS
                                                                   -------------------                                  ------

                                                                                OTHER
                                                                               ANNUAL            SECURITIES
                                                                               COMPEN-           UNDERLYING           ALL OTHER
      NAME AND PRINCIPAL POSITION             SALARY          BONUS            SATION             OPTIONS            COMPENSATION
      ---------------------------             ------          -----            ------             -------            ------------

<S>                                <C>         <C>              <C>          <C>                    <C>              <C>
E. Andrews Grinstead, III...........1998       $375,000         0            $ 93,750(1)            500,000          $ 53,861(2)
  Chairman of the Board,            1997       $375,000         0            $ 93,750(1)             66,806          $ 53,784(2)
  President and Chief Executive     1996       $375,000      $225,000        $ 93,750(1)             50,000          $ 48,163(2)
  Officer

Sudhir Agrawal, D. Phil.............1998       $250,000         0            $ 50,000(1)            500,000          $ 22,115(2)
  Senior Vice President of          1997       $250,000         0            $ 50,000(1)             32,263          $ 13,462(2)
  Discovery, Chief Scientific       1996       $250,000      $100,000         $ 4,277(1)             25,000          $ 24,399(2)
  Officer and Director
</TABLE>


- ----------------
(1)  Other annual  compensation  paid,  or to be paid, by the Company to, or for
     the benefit of, the Named Executive Officers is as follows:


<TABLE>
<CAPTION>
E. Andrews Grinstead, III                             1998                1997                      1996
- -------------------------                             ----                ----                      ----


<S>                                                  <C>                <C>                       <C>    
Paid in lieu of employee benefits............        $79,903            $34,902                   $76,017

Purchase of life insurance and other
payments to third parties....................         13,487             58,848                    17,733
                                                     -------            -------                   -------

Total........................................        $93,750            $93,750                   $ 93,750
                                                     =======            =======                   ========


                                       14

<PAGE>

Sudhir Agrawal, D. Phil.                               1998                1997                      1996
- ------------------------                               ----                ----                      ----

Paid in lieu of employee benefits............        $39,337              $38,132                    $ 0

Purchase of life insurance and other payments to
third parties................................         10,663               11,868                    4,277
                                                     -------              -------                   ------

Total........................................        $50,000              $50,000                   $4,277
                                                     =======              =======                   ======




(2)  All other compensation paid, or to be paid, by the Company to, or for the benefit of, the Named Executive
     Officers is as follows:


E. Andrews Grinstead, III                               1998                1997                     1996
- -------------------------                               ----                ----                     ----

Surrender of unused vacation days............         $37,861              $37,300                 $32,163
Additional payments..........................          16,000               16,484                  16,000
                                                      -------              -------                 -------


Total........................................         $53,861              $53,784                 $48,163
                                                       ======               ======                  ======


Sudhir Agrawal, D. Phil.                                1998                1997                     1996
- ------------------------                                ----                ----                     ----

Surrender of unused vacation days............         $22,115              $13,462                 $24,399
                                                       ------               ------                  ------


Total........................................         $ 22,115            $ 13,462                 $ 24,399
                                                      ========            ========                 ========
</TABLE>


Option Grants Table

     The following  table sets forth certain  information  concerning  grants of
stock options made during fiscal 1998 to each of the Named Executive Officers:


                        OPTION GRANTS IN LAST FISCAL YEAR

                                INDIVIDUAL GRANTS

<TABLE>
<CAPTION>

                                                                                                              POTENTIAL REALIZABLE
                                                     PERCENTAGE                                                 VALUE AT ASSUMED
                                 NUMBER OF            OF TOTAL                                                ANNUAL RATES OF STOCK
                                 SECURITIES            OPTIONS            EXERCISE                           PRICE APPRECIATION FOR
                                 UNDERLYING          GRANTED TO            PRICE           EXPIRA-               OPTIONS TERM(2)
                                  OPTIONS           EMPLOYEES IN            PER             TION        
                                  GRANTED            FISCAL YEAR           SHARE           DATE(1)          5%              10%
                                  --------           -----------          -------         --------       --------        ------



<S>                             <C>                    <C>                <C>          <C>              <C>              <C>
E. Andrews Grinstead, III..     500,000 (3)            21.4%              $2.00        7/21/08          $323,407         $1,107,416

Sudhir Agrawal, D.Phil.....     500,000 (3)            21.4%              $2.00        7/21/08          $323,407         $1,107,416

</TABLE>


- ---------------
(1)      The expiration  date of an option is the tenth  anniversary of the date
         on which the option was originally granted.


                                       15

<PAGE>

(2)      The amounts shown on this table represent hypothetical gains that could
         be achieved for the  respective  options if exercised at the end of the
         option  term.   These  gains  are  based  on  assumed  rates  of  stock
         appreciation  of 5% and  10%,  compounded  annually  from  the date the
         respective  options were granted to their  expiration  date.  The gains
         shown  are  net of  the  option  exercise  price,  but  do not  include
         deductions  for taxes or other expenses  associated  with the exercise.
         Actual  gains,  if any, on stock  option  exercises  will depend on the
         future  performance of the Common Stock, the  optionholders'  continued
         employment through the option period, and the date on which the options
         are  exercised.  As of April 16,  1999,  the last sale  price of Common
         Stock of the Company was lower than the  exercise  price of the options
         reflected in this table.

(3)      These stock options are currently  exercisable  with respect to 350,000
         of the shares covered thereby and will become  exercisable with respect
         to the remaining shares covered thereby in equal quarterly installments
         in arrears commencing on July 21, 1999.

Aggregated Option Exercises and Year-End Option Table

The following  table sets forth certain  information  concerning  the number and
value of  unexercised  options held by each of the Named  Executive  Officers on
December 31, 1998:


                       AGGREGATED OPTION EXERCISES IN LAST
                         FISCAL YEAR AND FISCAL YEAR-END
                                  OPTION VALUES

<TABLE>
<CAPTION>
                                                               NUMBER OF                              VALUE OF
                                                                 SHARES                             UNEXERCISED
                                                               UNDERLYING                           IN THE MONEY
                                                               OPTIONS AT                        OPTIONS AT FISCAL
                                                            FISCAL YEAR-END                         YEAR-END(1)

                                                              EXERCISABLE/                          EXERCISABLE/
                                                             UNEXERCISABLE                         UNEXERCISABLE
                                                             -------------                         -------------

<S>                                                  <C>                                             <C>      
E. Andrews Grinstead, III......................      461,235 / 302,084                               $ -- / --

Sudhir Agrawal.................................      340,903 / 277,360                              $3,750 / --
</TABLE>


- ---------------------

(1)  The  closing  price for the  Common  Stock as  reported  by The  Nasdaq OTC
     Bulletin  Board on December  31, 1998 (the last day of trading in 1998) was
     $1.625.  Value is  calculated  on the basis of the  difference  between the
     option  exercise  price and $1.625,  multiplied  by the number of shares of
     Common Stock underlying the option.


Director Compensation

     Each  non-employee  director  is paid  $1,500 for  personal  or  telephonic
attendance at a Board of Directors or committee meeting. Other directors are not
entitled to compensation in their capacities as directors.  All of the directors
are reimbursed for their expenses  incurred in connection with their  attendance
at Board of Directors and committee meetings. In addition, Dr. Zamecnik received
compensation  in the amount of $83,995 in 1998 in connection  with the provision
of certain  consulting  services to the Company.  Of this amount,  Dr.  Zamecnik
received  25,000 shares of Common Stock and warrants to purchase 6,250 shares of
Common Stock in lieu of $50,000 in cash. The remaining $33,995 was paid in cash.
The Company also is a party to consulting,  advisory and other arrangements with
various  directors  and their  affiliates.  For a  description  of the foregoing
arrangements with the Company and certain other transactions between the Company
and  affiliates of certain  directors,  see "Certain Transactions."


                                       16


<PAGE>

     In October 1995,  the Company  adopted the 1995 Director  Stock Option Plan
(the "Director Plan"). Under the terms of the Director Plan, options to purchase
1,000 shares of Common Stock were granted to each  director of the Company other
than Mr.  Grinstead and Dr.  Agrawal as of January 30, 1996 at an exercise price
of $65.625 per share,  and options to purchase 1,000 shares of Common Stock were
granted to each director  other than Mr.  Grinstead and Dr. Agrawal as of May 1,
1998 at an exercise  price of $2.375 per share.  The Director Plan also provides
that  options to purchase  5,000  shares of Common Stock will be granted to each
new director upon his or her initial  election to the Board of  Directors.  Such
options were granted to Messrs. Chebeir and Powell upon their appointment to the
Board of Directors in 1999.  Annual  options to purchase  1,000 shares of Common
Stock will be  granted  to each  eligible  director  on May 1 of each year.  All
options will vest on the first anniversary of the date of grant (or, in the case
of options  granted  automatically  each year, on April 30 of the year following
the date of grant);  provided,  that the exercisability of these options will be
accelerated  upon the  occurrence  of a change in  control  (as  defined  in the
Director  Plan). A total of 50,000 shares of Common Stock may be issued upon the
exercise of stock options granted under the Director Plan. The exercise price of
options  granted  under the  Director  Plan will equal the closing  price of the
Common Stock on the date of grant. As of April 16, 1999,  options to purchase an
aggregate of 21,000 shares of Common Stock were  outstanding  under the Director
Plan. All share  information  set forth in the Proxy Statement has been adjusted
to take into  account the  one-for-five  reverse  stock  split of the  Company's
Common Stock  effected in December 1997. For a description of the Director Plan,
see  "Proposal 3 -- Approval of  Amendment  to the 1995  Director  Stock  Option
Plan."

     Non-employee  directors also have received options to purchase Common Stock
of the Company under the Company's  1997 Stock Option Plan (the "1997 Plan") and
the Company's 1995 Stock Option Plan (the "1995 Plan"). In particular,  in 1998,
the Board of  Directors  voted to grant an option to purchase  50,000  shares of
Common  Stock  at  $2.00  per  share  to Dr.  Wyngaarden  and  Mr.  El-Zein,  in
recognition of their services as Vice Chairmen of the Board of Directors  during
the previous twelve months. Mr. El-Zein declined this grant.

     In addition,  in 1998, the Board of Directors  voted to grant 50,000 shares
of Common Stock of the Company to Dr. Zamecnik in recognition of his outstanding
contributions to the Company.


Employment   Agreements,   Termination  of  Employment  and  Change  in  Control
Arrangements

         The Company is party to an employment  agreement with Mr. Grinstead for
the  period  commencing  July 1,  1996 and  ending  June 30,  2001.  Under  this
agreement,  Mr. Grinstead is currently entitled to receive an annual base salary
of  $375,000.  Mr.  Grinstead  also is eligible to receive (i) a cash bonus each
year related to the attainment of management  objectives  specified by the Board
of Directors and (ii) additional  payments of $16,000 in 1996, 1997 and 1998. In
the event Mr. Grinstead's  employment is terminated by the Company without cause
(as  defined) or by him for good cause (as  defined),  the Company  will pay Mr.
Grinstead  during the 24-month period following his termination a monthly amount
equal to one-twelfth of the sum of Mr.  Grinstead's annual base salary as of the
date of  termination  and the  average  bonus paid to him during the three years
preceding his termination  (the "Average Bonus  Amount").  The Company also will
continue  Mr.  Grinstead's   benefits  for  such  period,   subject  to  earlier
termination under certain circumstances.  If his employment is terminated by the
Company for failure to perform his assigned duties,  he will continue to receive
his annual base salary and benefits during the six-month  period  following such
termination.  Notwithstanding  the foregoing,  in the event that Mr. Grinstead's
employment is terminated for any of the above reasons within 12 months following
a Change in Control (as defined) of the Company,  Mr. Grinstead will be entitled
to receive, in lieu of the payments described above, a lump sum payment equal to
300% of the sum of his annual base salary and his Average Bonus Amount.

         In accordance  with the terms of Mr.  Grinstead's  previous  employment
agreement,  the Company  loaned  $190,000  to Mr.  Grinstead  in  December  1992
pursuant to the terms of a promissory  note bearing simple interest at a rate of
6% per year,  which  originally  provided for the payment of  principal  and all
accrued  interest  on the  earlier of December  23,  1995 or the  expiration  or
termination  of Mr.  Grinstead's  employment  by the  Company,  but is currently
payable on demand.  Such loan remained  outstanding  as of December 31, 1998, at
which date the total unpaid balance of principal and interest was $258,650.


                                       17


<PAGE>

         The Company is party to an employment  agreement  with Dr.  Agrawal for
the  period  commencing  July 1,  1996 and  ending  June 30,  2000.  Under  this
agreement,  Dr.  Agrawal  serves as Senior Vice President of Discovery and Chief
Scientific Officer of the Company and is currently entitled to receive an annual
base salary of  $250,000.  Dr.  Agrawal is eligible to receive a cash bonus each
year related to the attainment of management  objectives  specified by the Chief
Executive  Officer  and the  Board of  Directors.  In the  event  Dr.  Agrawal's
employment is terminated by the Company without cause (as defined) or by him for
good cause (as defined),  the Company will pay Dr.  Agrawal  during the 24-month
period  following his  termination a monthly  amount equal to one-twelfth of the
sum of Dr.  Agrawal's  annual base salary as of the date of termination  and the
average bonus paid to him during the three years preceding his termination  (the
"Average Bonus Amount").  The Company will also continue Dr. Agrawal's  benefits
for such period, subject to earlier termination under certain circumstances.  If
his  employment is terminated by the Company for failure to perform his assigned
duties,  he will continue to receive his annual base salary and benefits  during
the six-month period following such termination.  Notwithstanding the foregoing,
in the event that Dr.  Agrawal's  employment is terminated  for any of the above
reasons  within 12 months  following  a Change in Control  (as  defined)  of the
Company,  Dr.  Agrawal  will be  entitled to  receive,  in lieu of the  payments
described  above, a lump sum payment equal to 300% of the sum of his annual base
salary and his Average Bonus Amount.

         The employment  agreements entered into between the Company and each of
Mr. Grinstead and Dr. Agrawal also provide that all stock options held by any of
the Named  Executive  Officers  (including  existing  options  and options to be
granted in the future) shall include terms  providing (i) that in the event that
such Named Executive  Officer's  employment is terminated by the Company without
cause or by him for good cause the  exercisability of such stock options will be
accelerated  by two years  and such  stock  options  will be  exercisable  for a
two-year  period  following  termination  and (ii) that in the event of  certain
changes  in  control  of the  Company,  its  liquidation  or the  sale of all or
substantially  all of its assets,  all such stock  options not then  exercisable
will vest and become  immediately  exercisable.  The  Company is also a party to
registration rights agreements with Mr. Grinstead that provide that in the event
the Company proposes to register any of its securities under the Securities Act,
at any time, with certain exceptions, Mr. Grinstead shall be entitled to include
the  shares of Common  Stock  held by him in such  registration,  subject to the
right of the managing  underwriter of any underwritten  offering to exclude from
such registration for marketing reasons some or all of such shares.  The Company
also is a party to  indemnification  agreements with Mr.  Grinstead  pursuant to
which the Company has agreed to indemnify him for certain liabilities, including
liabilities arising under the Securities Act.

         Stock  options to purchase  an  aggregate  of 207,513  shares of Common
Stock granted to the Named Executive  Officers pursuant to the 1990 Plan provide
that,  upon a change in control  (as  defined  in the 1990  Plan),  all  options
granted thereunder will become fully exercisable.  In addition,  pursuant to the
terms of the employment  agreements entered into between the Company and each of
the Named Executive Officers described above (i) in April 1997, stock options to
purchase an  aggregate of 156,069  shares of Common  Stock  granted to the Named
Executive  Officers  under the Company's  1995 Plan were amended to provide that
such  options  will  become  fully  exercisable  upon a change in control of the
Company,  and (ii) all stock  options  granted to the Named  Executive  Officers
after March 1, 1997 will provide that such options will become fully exercisable
upon a change of control of the Company.


Compensation Committee Interlocks and Insider Participation

         On June 16, 1998 the Board of Directors  re-established  a Compensation
Committee  consisting of Messrs.  Berry and El-Zein and Dr. Wyngaarden.  None of
the  directors  or  executive  officers  of  the  Company  had  any  "interlock"
relationships  to report  during the  Company's  fiscal year ended  December 31,
1998.

         Since  January 1, 1998,  the Company has entered  into or is engaged in
certain ongoing  transactions  with (i) Pillar S.A., Pillar  Investment,  Pillar
Limited  and  Charles  River  Building  Limited  Partnership,  entities of which
Messrs.  El-Zein and Menhall are affiliates;  (ii) entities advised by Pecks, an
entity of which Mr.

                                       18

<PAGE>



Berry is a  principal  and (iii)  Forum,  an  entity  of which Mr.  Purkey is an
affiliate. See "Certain Transactions."


Report of the Compensation Committee on Executive Compensation

         The Company's  Compensation  Committee is responsible for  establishing
compensation   policies  with  respect  to  the  Company's  executive  officers,
including the Chief Executive Officer and the other executive  officers named in
the  Summary   Compensation  Table,  and  setting  the  compensation  for  these
individuals.

         The  Compensation  Committee  seeks to  achieve  three  broad  goals in
connection  with the  Company's  executive  compensation  programs and decisions
regarding individual compensation.  First, the Compensation Committee structures
executive  compensation  programs in a manner  that it believes  will enable the
Company to attract and retain key executives.  In order to ensure  continuity of
certain key  members of  management,  the Board of  Directors  has  historically
approved  multi-year  employment  contracts  for  its  executives.  Second,  the
Compensation  Committee  establishes  compensation programs that are designed to
reward  executives  for the  achievement  of business  objectives of the Company
and/or the individual executive's particular area of responsibility.  By linking
compensation in part to achievement,  the Compensation Committee believes that a
performance-oriented  environment  is  created  for  the  Company's  executives.
Finally, the Company's executive  compensation  programs are intended to provide
executives with an equity interest in the Company so as to link a portion of the
compensation  of the Company's  executives with the performance of the Company's
Common Stock.

         The compensation  programs for the Company's executives  established by
the Compensation  Committee  generally  consist of three elements based upon the
foregoing  objectives:  base  salary;  cash  bonuses  and a  stock-based  equity
incentive in the form of  participation in the Company's stock option plans. The
Compensation  Committee  did  not  consider  cash  bonuses  in  1998  due to the
Company's cash position.

         In establishing base salaries for the executive officers, including the
Chief  Executive  Officer,  which base salaries have been fixed in the executive
officers'  employment  agreements,  the Board of Directors  monitors salaries at
other companies, particularly those that are in the same industry as the Company
or related  industries and/or located in the same general geographic area as the
Company,  considers  historic  salary levels of the individual and the nature of
the individual's responsibilities and compares the individual's base salary with
those of other  executives  at the  Company.  The  Compensation  Committee  also
considers the challenges involved in retaining  first-rate  managerial personnel
in the  antisense  field  because of the new nature of this  technology.  To the
extent determined to be appropriate,  the Compensation  Committee also considers
general  economic  conditions,  the  Company's  financial  performance  and  the
individual's performance.

         The Compensation  Committee uses stock options as a significant element
of the compensation  package of the Company's executive officers,  including the
Chief  Executive  Officer,  because they provide an incentive to  executives  to
maximize  stockholder  value and because they reward the executives  only to the
extent that  stockholders  also  benefit.  The timing and amounts of such grants
depends  upon a number  of  factors,  including  new  hires of  executives,  the
executives'  current  stock and option  holdings  and such other  factors as the
Compensation  Committee deems relevant. In granting stock options in 1998 to the
Company's  executives,  including  Mr.  Grinstead,  the  Compensation  Committee
considered a variety of factors,  including the Company's accomplishments in the
areas of product development,  enhancement of the Company's patent and licensing
position,  restructuring  and increased  development  of the Hybridon  Specialty
Products Division. Likewise, the grant of stock options to Mr. Grinstead in 1998
was based on the Compensation Committee's judgment as to the leadership role Mr.
Grinstead  played with respect to these  accomplishments.  When  granting  stock
options,  it has generally been the policy of the Compensation  Committee to fix
the  exercise  price of such  options  at 100% of the fair  market  value of the
Common Stock on the date of grant.


                                       19


<PAGE>

         Section  162(m) of the Internal  Revenue Code of 1986,  as amended (the
"Code"),  enacted  in  1993,  generally  disallows  a tax  deduction  to  public
companies for compensation  over $1,000,000 paid to its chief executive  officer
and its four  other  most  highly  compensated  executive  officers.  Qualifying
performance-based  compensation  will not be subject to the  deduction  limit if
certain requirements are met. In this regard, the Company has limited the number
of shares subject to stock options which may be granted to Company  employees in
a manner  that  complies  with the  performance-based  requirements  of  Section
162(m).  Based  on the  compensation  awarded  to Mr.  Grinstead  and the  other
executive  officers of the Company,  it does not appear that the Section  162(m)
limitation will have a significant impact on the Company in the near term. While
the  Committee  does not currently  intend to qualify its incentive  awards as a
performance-based plan, it will continue to monitor the impact of Section 162(m)
on the Company.

                                                      COMPENSATION COMMITTEE OF
                                                      THE BOARD OF DIRECTORS

                                                      Arthur W. Berry
                                                      Youssef El-Zein
                                                      James B. Wyngaarden


Comparative Stock Performance

The  comparative   stock   performance   graph  below  compares  the  cumulative
stockholder return on the Company's Common Stock for the period from January 25,
1996 (the effective date of the initial public offering of the Company's  Common
Stock)  through  December 31, 1998 with the  cumulative  total return on (i) the
Nasdaq Market Index and (ii) a peer group index (the "SIC Code Index")  selected
by the Company which is comprised of the 90 publicly traded companies, including
the Company,  that are  currently  grouped  under the Standard  Industrial  Code
pertaining to businesses engaged in the manufacture or development of biological
products other than  diagnostic  substances  (assuming the investment of $100 in
the Company's  Common  Stock,  the Nasdaq Market Index and the SIC Code Index on
January 25, 1996 and reinvestment of all dividends).  Measurement  points are on
January 25, 1996, December 31, 1996, December 31, 1997, March 31, 1998, June 30,
1998, September 30, 1998 and the last trading day of the year ended December 31,
1998.  Prior to January 25, 1996, the Company's  Common Stock was not registered
under the Exchange Act.


<TABLE>
<CAPTION>
      Measurement Period                                                 Nasdaq Market
    (Fiscal Year Covered)                Hybridon Inc                        Index                      SIC Code Index
    ---------------------                ------------                        -----                      --------------

          <S>                                <C>                              <C>                            <C>
           1/25/96                           100.00                           100.00                         100.00

           12/31/96                           55.95                           120.16                          94.51

           12/31/97                            5.71                           146.98                         102.98

           3/31/98                             4.76                           172.26                         114.33

           6/30/98                             4.76                           176.71                         112.88

           9/30/98                             4.29                           159.27                         116.51

           12/31/98                            3.10                           207.04                         161.67

</TABLE>

                               [GRAPH OMMITTED]


                                       20


<PAGE>

        PROPOSAL 2 -- APPROVAL OF AMENDMENT TO 1997 STOCK INCENTIVE PLAN

         The Board of Directors has approved an amendment to the company's  1997
Stock  Incentive  Plan (the "1997 Plan") which,  if adopted,  would increase the
number of shares authorized for issuance thereunder by 2,000,000 shares.

         The 1997 Plan was adopted by the Board of  Directors  on March 20, 1997
and approved by the Company's  stockholders  on April 21, 1997.  Currently,  the
1997 Plan  provides for the issuance of up to 4,500,000  shares of Common Stock.
The Board of Directors  believes that the continued growth and  profitability of
the Company depends,  in large part, upon the ability of the Company to maintain
a competitive position in attracting, retaining and motivating key personnel. As
of April  16,1999,  approximately  1,300,000  shares were  available  for future
Awards under the Company's  1997 Plan.  Accordingly,  on February 22, 1999,  the
Board of Directors authorized,  subject to shareholder approval, an amendment to
the 1997 Plan that increases the number of shares of Common Stock  available for
issuance under the 1997 Plan from 4,500,000  shares to 6,500,000 shares (subject
to  a   proportionate   adjustment   for  certain   changes  in  the   Company's
capitalization,  such as a stock split). The increase in the number of shares of
Common Stock  reserved for issuance  under the 1997 Plan will permit the Company
to continue the operation of the 1997 Plan for the benefit of new  participants,
as well as to allow additional awards to current participants.

         The major features of the 1997 Plan are summarized below, which summary
is qualified  in its  entirety by the actual text of the 1997 Plan.  The text of
the  amendment,  subject  to your  approval,  appears  as Exhibit A to the Proxy
Statement.  The Company will furnish  without  charge a copy of the 1997 Plan to
any  stockholder  of the Company upon receipt from any such person of an oral or
written  request for the 1997 Plan.  Such request should be sent to the Company,
Attention  of Investor  Relations,  155 Fortune  Blvd.,  Milford,  Massachusetts
01757, or made by telephone at (508) 482-7500.

Description of Awards

         The 1997 Plan  provides  for the grant of options  that are intended to
qualify as incentive stock options within the meaning of Section 422 of the Code
("incentive stock options"),  options not intended to qualify as incentive stock
options  ("nonstatutory  stock  options"),  restricted  stock  awards  and other
stock-based awards, including the grant of shares based upon certain conditions,
the grant of  securities  convertible  into Common  Stock and the grant of stock
appreciation rights (collectively "Awards").

Incentive Stock Options and Nonstatutory Stock Options

         Optionees receive the right to purchase a specified number of shares of
Common Stock at some time in the future at a specified  option price and subject
to such other terms and  conditions  as are  specified  in  connection  with the
option  grant.  Options  may be granted at an  exercise  price which may be less
than,  equal to or greater than the fair market value of the Common Stock on the
date of grant.  Under present law, however,  incentive stock options and options
intended to qualify as  performance-based  compensation  under Section 162(m) of
the Code may not be granted at an exercise price less than the fair market value
of the Common  Stock on the date of grant (or less than 110% of the fair  market
value in the case of incentive stock options granted to optionees holding 10% or
more of the voting  power of the  Company).  The 1997 Plan  permits the Board of
Directors to determine  the manner of payment of the exercise  price of options,
including  through  payment by cash,  check or in  connection  with a  "cashless
exercise"  through a broker,  by  surrender  to the  Company of shares of Common
Stock,  by delivery to the Company of a promissory  note, or by any other lawful
means.

Restricted Stock Awards

         Restricted Stock Awards entitle  recipients to acquire shares of Common
Stock,  subject to the right of the  Company to  repurchase  all or part of such
shares from the  recipient  in the event that the  conditions  specified  in the
applicable  Award  are  not  satisfied  prior  to  the  end  of  the  applicable
restriction period established for such Award.


                                       21


<PAGE>

Other Stock-Based Awards

         Under the 1997  Plan,  the Board  has the right to grant  other  Awards
based upon the Common  Stock having such terms and  conditions  as the Board may
determine,  including  the grant of shares  based upon certain  conditions,  the
grant  of  securities  convertible  into  Common  Stock  and the  grant of stock
appreciation rights.

Eligibility to Receive Awards

         Officers, employees, directors, consultants and advisors of the Company
and its  subsidiaries  are  eligible to be granted  Awards  under the 1997 Plan.
Under  present  law,  however,  incentive  stock  options may only be granted to
employees.  The maximum  number of shares with  respect to which an Award may be
granted to any participant under the 1997 Plan may not exceed 500,000 shares per
calendar year.

         As of April 16, 1999, approximately 65 persons were eligible to receive
Awards  under  the 1997  Plan,  including  all of the  Company's  employees  and
consultants,  and the Company's two  executive  officers and eight  non-employee
directors. The granting of Awards under the 1997 Plan is discretionary,  and the
Company  cannot now  determine the number or type of Awards to be granted in the
future to any particular person or group.

Administration

         The 1997 Plan is administered by the Board of Directors.  The Board has
the authority to adopt,  amend and repeal the administrative  rules,  guidelines
and practices  relating to the 1997 Plan and to interpret the  provisions of the
1997 Plan.  Pursuant to the terms of the 1997 Plan,  the Board of Directors  may
delegate  authority  under the 1997 Plan to one or more committees of the Board,
and subject to certain  limitations,  to one or more  executive  officers of the
Company.  Subject to any applicable  limitations contained in the 1997 Plan, the
Board of  Directors,  or any  committee or  executive  officer to whom the Board
delegates  authority,  as the case may be,  selects the recipients of Awards and
determines  (i) the number of shares of Common Stock  covered by options and the
dates upon which such options  become  exercisable,  (ii) the exercise  price of
options,  (iii) the duration of options, and (iv) the number of shares of Common
Stock subject to any restricted stock or other stock-based  Awards and the terms
and conditions of such Awards, including conditions for repurchase,  issue price
and repurchase price.

         The Board of Directors is required to make  appropriate  adjustments in
connection  with the 1997  Plan and any  outstanding  Awards  to  reflect  stock
dividends,  stock  splits and certain  other  events.  In the event of a merger,
liquidation or other  Acquisition  Event (as defined in the 1997 Plan), the 1997
Plan provides that the vesting of all outstanding  Options or other  stock-based
Awards  will  accelerate,  making  them  fully  exercisable  prior  to  or  upon
consummation of the Acquisition Event.

         If  any  Award  expires  or is  terminated,  surrendered,  canceled  or
forfeited, the unused shares of Common Stock covered by such Award will again be
available for grant under the 1997 Plan.

Amendment or Termination

         No Award may be made  under the 1997 Plan  after  March 20,  2007,  but
Awards  previously  granted may extend beyond that date.  The Board of Directors
may at any time  amend,  suspend  or  terminate  the 1997 Plan,  except  that no
outstanding  Award  designated  as subject to Section  162(m) of the Code by the
Board of Directors  after the date of such amendment  shall become  exercisable,
realizable  or vested (to the extent such  amendment  was required to grant such
Award) unless and until such amendment shall have been approved by the Company's
stockholders.


                                       22


<PAGE>

Federal Income Tax Consequences

         The  following  is a summary of the United  States  federal  income tax
consequences  that generally will arise with respect to Awards granted under the
1997 Plan and with respect to the sale of Common Stock  acquired  under the 1997
Plan.

Incentive Stock Options

         In general,  a participant  will not recognize  taxable income upon the
grant or exercise of an incentive  stock option.  Instead,  a  participant  will
recognize taxable income with respect to an incentive stock option only upon the
sale of Common Stock acquired  through the exercise of the option ("ISO Stock").
The exercise of an incentive stock option may, however,  subject the participant
to the alternative minimum tax.  Generally,  the tax consequences of selling ISO
Stock will vary with the length of time that the  participant  has owned the ISO
Stock at the time it is sold.  If the  participant  sells ISO Stock after having
owned it for at least two years from the date the option was granted (the "Grant
Date")  and one year  from the date the  option  was  exercised  (the  "Exercise
Date"),  then the participant will recognize long-term capital gain in an amount
equal to the excess of the sale price of the ISO Stock over the exercise price.

         If the  participant  sells ISO Stock for more than the  exercise  price
prior to having owned it for at least two years from the Grant Date and one year
from the Exercise Date (a "Disqualifying Disposition"), then all or a portion of
the gain recognized by the participant will be ordinary  compensation income and
the remaining  gain, if any, will be a capital gain. This capital gain will be a
long-term  capital gain if the  participant has held the ISO Stock for more than
one year prior to the date of sale.

         If a participant sells ISO Stock for less than the exercise price, then
the participant will recognize  capital loss equal to the excess of the exercise
price  over the  sale  price  of the ISO  Stock.  This  capital  loss  will be a
long-term  capital loss if the  participant has held the ISO Stock for more than
one year prior to the date of sale.

Nonstatutory Stock Options

         As in the case of an incentive  stock option,  a  participant  will not
recognize taxable income upon the grant of a nonstatutory  stock option.  Unlike
the case of an incentive stock option, however, a participant who exercises of a
nonstatutory stock option generally will recognize ordinary  compensation income
in an amount  equal to the excess of the fair market  value of the Common  Stock
acquired  through the exercise of the option ("NSO  Stock") on the Exercise Date
over the exercise price.

         With  respect to any NSO  Stock,  a  participant  will have a tax basis
equal to the exercise price plus any income  recognized upon the exercise of the
option.  Upon selling NSO Stock, a participant  generally will recognize capital
gain or loss in an amount equal to the excess of the sale price of the NSO Stock
over the  participant's  tax basis in the NSO Stock.  This  capital gain or loss
will be a long-term gain or loss if the  participant  has held the NSO stock for
more than one year prior to the date of the sale.

Restricted Stock Awards

         A  participant  will not recognize  taxable  income upon the grant of a
restricted stock Award,  unless the participant  makes an election under Section
83(b) of the Code (a  "Section  83(b)  Election").  If the  participant  makes a
Section  83(b)  Election  within  30 days of the  date of the  grant,  then  the
participant will recognize  ordinary income,  for the year in which the Award is
granted,  in an amount equal to the difference  between the fair market value of
the Common  Stock at the time the Award is granted and the  purchase  price paid
for the Common Stock.  If a Section 83(b) Election is not made, the  participant
will recognize  ordinary income,  at the time that the forfeiture  provisions or
restrictions on transfer lapse, in an amount equal to the difference between the
fair market value of the Common Stock at the time of such lapse and the original
purchase price paid for the


                                       23


<PAGE>

Common Stock.  The  participant  will have a basis in the Common Stock  acquired
equal to the sum of the  price  paid and the  amount  of  ordinary  compensation
income recognized.

         Upon  the  disposition  of the  Common  Stock  acquired  pursuant  to a
restricted  stock Award,  the participant  will recognize a capital gain or loss
equal to the  difference  between  the sale  price of the  Common  Stock and the
participant's  basis in the Common  Stock.  The gain or loss will be a long-term
gain or loss if the  shares are held for more than one year.  For this  purpose,
the  holding  period  shall  begin just  after the date on which the  forfeiture
provisions or  restrictions  lapse if a Section  83(b)  Election is not made, or
just after the Award is granted if a Section 83(b) Election is made.

Other Stock-Based Awards

         The tax  consequences  associated  with  any  other  stock-based  Award
granted  under the 1997 Plan will vary  depending on the specific  terms of such
Award,  including  whether  or not the Award has a  readily  ascertainable  fair
market value,  whether or not the Award is subject to  forfeiture  provisions or
restrictions  on  transfer,  the nature of the  property  to be  received by the
participant under the Award, the applicable holding period and the participant's
tax basis.

Tax Consequences to the Company

         The grant of an Award under the 1997 Plan will have no tax consequences
to the Company. Moreover, in general, neither the exercise of an incentive stock
option nor the sale of any Common Stock  acquired  under the 1997 Plan will have
any tax consequences to the Company. The Company generally will be entitled to a
business-expense  deduction,  however, with respect to any ordinary compensation
income recognized by a participant under the 1997 Plan, including as a result of
the exercise of a nonstatutory  stock option,  a Disqualifying  Disposition or a
Section 83(b) Election. Any such deduction will be subject to the limitations of
Section 162(m) of the Code. The Company will have a withholding  obligation with
respect to any ordinary compensation income recognized by participants under the
1997 Plan who are employees or otherwise  subject to  withholding  in connection
with the exercise of a nonstatutory stock option or a Section 83(b) Election.

Amendment No. 1 to the 1997 Plan

         At the 1998 Annual Meeting of Stockholders,  the stockholders  approved
an amendment to the 1997 Plan that (1)  increased the number of shares of Common
Stock  available  for issuance  under the 1997 Plan from 600,000  shares  (after
taking into account the one-for-five reverse stock split of the Company's Common
Stock effected in December 1997) to 4,500,000 shares (subject to a proportionate
adjustment for certain changes in the Company's capitalization,  such as a stock
split),  and (2)  increased  the number  shares of Common  Stock with respect to
which an Award may be granted to a participant  under the 1997 Plan per calendar
year from 100,000 (after taking into account the reverse stock split referred to
above) to 500,000  (which  represents the same number of shares which could have
been granted before such reverse stock split).


         THE BOARD OF DIRECTORS  BELIEVES  THAT APPROVAL OF THE AMENDMENT OF THE
1997 PLAN IS IN THE BEST  INTERESTS  OF THE  COMPANY  AND THE  STOCKHOLDERS  AND
THEREFORE,  UNANIMOUSLY  RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" APPROVAL OF THE
AMENDMENT OF THE 1997 PLAN.


                                       24


<PAGE>

                     PROPOSAL 3 -- APPROVAL OF AMENDMENT TO
                         1995 DIRECTOR STOCK OPTION PLAN

         The Board of Directors has approved an amendment to the Company's  1995
Director  Stock  Option Plan (the  "Director  Plan")  which,  if adopted,  would
increase  the number of shares  authorized  for issuance  thereunder  by 350,000
shares.

         The Director  Plan was adopted by the Board of Directors on October 30,
1995.  Currently,  the plan  provides for the issuance of up to 50,000 shares of
the Common Stock. The Board of Directors  believes that the continued growth and
profitability  of the Company  depends,  in large part,  upon the ability of the
Company to maintain a competitive position in attracting and retaining ownership
in the Company by outside  directors.  As of April  16,1999,  29,000 shares were
available  for stock  option  grants under the Director  Plan.  Accordingly,  on
February 22, 1999,  the Board of Directors  authorized,  subject to  shareholder
approval,  an amendment to the Director Plan that increases the number of shares
of Common Stock available for issuance under the Director Plan to 400,000 shares
(subject to a  proportionate  adjustment  for certain  changes in the  Company's
capitalization, such as a stock split.)

         Additionally, the Director Plan provides for automatic annual grants to
each outside  director of an option to purchase  5,000  shares of the  Company's
Common Stock.  As a result of the  one-for-five  reverse stock split effected in
December  1997,  the number of options to purchase  the  Company's  Common Stock
granted to each outside  director  was  adjusted so that each  outside  director
received  options to  purchase  1,000  shares of Common  Stock in 1998 (and will
receive an  additional  1,000  options on May 1, 1999)  instead of 5,000 on both
dates,  although the Director Plan does not require this adjustment.  Management
of the  Company  believes  that in order to maintain a  competitive  position in
attracting  and  retaining  ownership in the Company by outside  directors it is
necessary  to make an  annual  grant of an option to  purchase  5,000  shares of
Common Stock to each director under the Director Plan. Accordingly,  on February
22, 1999, the Board of Directors authorized,  subject to stockholder approval, a
one-time grant of options to purchase 8,000 shares of the Company's Common Stock
(which,  in addition to the options to purchase 1,000 shares  granted,  or to be
granted in each of 1998 and 1999,  as described  above,  would give each outside
director options to purchase a total of 10,000 shares, or 5,000 for each of 1998
and 1999, of the Company's Common Stock.)

         For the reasons discussed in the paragraph above, on February 22, 1999,
the Board of Directors authorized, subject to stockholder approval, an amendment
to the Director  Plan that  clarifies  that options to purchase  5,000 shares of
Common Stock be granted to each outside director  (annually and upon appointment
to the Board).


         The major features of the 1997 Plan are summarized below, which summary
is qualified in its entirety by the actual text of the Director  Plan.  The text
of the amendment,  subject to your  approval,  appears as Exhibit B to the Proxy
Statement.  The Company will furnish  without charge a copy of the Director Plan
to any  stockholder  of the Company upon receipt from any such person of an oral
or written  request for the Director  Plan.  Such request  should be sent to the
Company,   Attention  of  Investor  Relations,   155  Fortune  Blvd.,   Milford,
Massachusetts 01757, or made by telephone at (508) 482-7500.


Description of Awards

         The  Director  Plan  provides  for the  grants of  non-qualified  stock
options to the Company's non-employee directors.

         Optionees receive the right to purchase a specified number of shares of
Common Stock at some time in the future at a specified  option price and subject
to such other terms and  conditions  as are  specified  in  connection  with the
option grant. Options may only be granted at an exercise price equal to the fair
market  value of the  Common  Stock  on the date of  grant.  An  Option  becomes
exercisable on the first anniversary of the


                                       25


<PAGE>

date on which the option was granted,  provided  that the optionee  continues to
serve as a director of the Company on such date. Each option  terminates and may
no longer be  exercised  on the earlier of (i) that date 10 years after the date
on which the  option was  granted  or (ii) the date 60 days  after the  optionee
ceases to serves as a director of the  Company.  The  Director  Plan permits the
exercise  of an option only by written  notice to the  Company at its  principal
office  accompanied by payment in cash of the full  consideration for the shares
as to which the option is exercised.

         The  reported  closing  bid price of the  Common  Stock on the NASD OTC
Bulletin  Board on April 16,  1999 was $1.25 per share.  Subject to  stockholder
approval at the Annual Meeting,  non-employee  directors will receive options to
purchase a total of 64,000  shares of the  Company's  Common Stock as of June 8,
1999.

Eligibility to Receive Options

         Directors of the Company who are not full time employees of the Company
or any  subsidiary  of the  Company  ("outside  directors")  are  eligible to be
granted options under the Director Plan.

         As of April 16, 1999,  there were eight outside  directors  eligible to
receive Options under the Director Plan.

<TABLE>
<CAPTION>
                                               Amended Plan Benefits
                                          1995 Director Stock Option Plan

Name and Position                                   Dollar Value ($)                         Number of Units
- -----------------                                   ----------------                         ---------------

<S>                                                         <C>                                     <C>
E. Andrews Grinstead, III
Chairman of the Board, President                            0                                       0
and Chief Executive Officer

Sudhir Agrawal
Senior Vice President of                                    0                                       0
Discovery, Chief Scientific
Officer and Director

Executive Group                                             0                                       0

Non-Executive Director Group                               (1)                                  72,000(2)

Non-Executive Officer Employee                              0                                       0
Group
</TABLE>

- ------------------
(1)      Options  are granted  with an  exercise  price equal to the fair market
         value of the underlying Common Stock on the date of the grant.

(2)      Reflects  option  grants  to be made in 1999 to  directors  who are not
         employees of the Company ("outside  directors")as  follows: (i) options
         to purchase  1,000  shares are being  granted to each of eight  outside
         directors on May 1, 1999,  and (ii) options to purchase 8,000 shares of
         the Company's  Common Stock are being granted to each outside  director
         serving on June 8, 1999.


Administration

         The Director Plan is administered by the Board of Directors.  The Board
has  the  authority  to  adopt,  amend  and  repeal  the  administrative  rules,
guidelines  and  practices  relating to the Director  Plan and to interpret  the
provisions of the Director Plan.


                                       26


<PAGE>

         The Board of Directors is required to make  appropriate  adjustments in
connection with the Director Plan and any  outstanding  options to reflect stock
dividends,  stock  splits and certain  other  events.  In the event of a merger,
liquidation  or other Change in Control (as defined in the Director  Plan),  the
Director  Plan  provides  that  the  vesting  of all  outstanding  options  will
accelerate,  making them fully  exercisable prior to or upon consummation of the
Change in Control.

         If any  option  expires  or is  terminated,  surrendered,  canceled  or
forfeited,  the unused  shares of Common Stock covered by such option will again
be available for grant under the Director Plan.

Amendment or Termination

         The Board of  Directors  may  suspend,  terminate  or  discontinue  the
Director Plan or amend it in any respect  whatsoever;  provided,  however,  that
without  approval of the  stockholders  of the  Company,  no  amendment  may (i)
increase the number of shares  subject to the  Director  Plan,  (ii)  materially
modify the  requirements as to eligibility to receive options under the Director
Plan, or (iii) materially  increase the benefits accruing to participants in the
Director  Plan;  and provided  further that the Board of Directors may not amend
those  provisions of the Director  Plan  concerning  participation  in the plan,
option grant dates, or option exercise price more frequently than once every six
months,  other than to comply with changes in the  Internal  Revenue Code or the
rules thereunder.


Federal Income Tax Consequences

         The  following  is a summary of the United  States  federal  income tax
consequences that generally will arise with respect to the options granted under
the Director  Plan and with respect to the sale of Common Stock  acquired  under
the Director Plan.

Tax Consequences to Participants

         A participant  will not recognize  taxable  income upon the grant of an
option.  However, a participant who exercises an option generally will recognize
ordinary compensation income in an amount equal to the excess of the fair market
value of the Common Stock acquired  through the exercise of the option  ("Option
Stock") on the Exercise Date over the exercise price.

         With respect to any Option Stock,  a participant  will have a tax basis
equal to the exercise price plus any income  recognized upon the exercise of the
option.  Upon selling  Option Stock,  a  participant  generally  will  recognize
capital  gain or loss in an amount  equal to the excess of the sale price of the
Option Stock over the  participant's tax basis in the Option Stock. This capital
gain or loss will be a long-term  gain or loss if the  participant  has held the
Option Stock for more than one year prior to the date of the sale.

Tax Consequences to the Company

         The  grant of an  option  under  the  Director  Plan  will  have no tax
consequences  to the Company.  Moreover,  the sale of any Common Stock  acquired
under the Director Plan will not have any tax  consequences to the Company.  The
Company  generally will be entitled to a  business-expense  deduction,  however,
with respect to any ordinary  compensation  income  recognized  by a participant
under the Director Plan, including as a result of the exercise of a nonstatutory
stock option.

         THE BOARD OF DIRECTORS  BELIEVES  THAT APPROVAL OF THE AMENDMENT OF THE
DIRECTOR PLAN IS IN THE BEST INTERESTS OF THE COMPANY AND THE  STOCKHOLDERS  AND
THEREFORE,  UNANIMOUSLY  RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" APPROVAL OF THE
AMENDMENT OF THE DIRECTOR PLAN.


                                       27


<PAGE>

             PROPOSAL 4 -- RATIFICATION OF THE SELECTION OF AUDITORS

         The Board of Directors has selected  Arthur Andersen LLP as auditors of
the Company for the year ending  December 31, 1999,  subject to  ratification by
stockholders  at the  Annual  Meeting.  If the  stockholders  do not  ratify the
selection of Arthur  Andersen LLP, the Board of Directors  will  reconsider  the
matter.  A  representative  of Arthur Andersen LLP, which served as auditors for
the year  ended  December  31,  1998,  is  expected  to be present at the Annual
Meeting to respond to  appropriate  questions,  and to make a statement if he or
she so desires.

         THE BOARD OF DIRECTORS  BELIEVES  THAT APPROVAL TO RATIFY THE SELECTION
OF AUDITORS IS IN THE BEST  INTERESTS  OF THE COMPANY AND THE  STOCKHOLDERS  AND
THEREFORE,  UNANIMOUSLY  RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" APPROVAL OF THE
AUDITORS.


                  STOCKHOLDER PROPOSALS FOR 2000 ANNUAL MEETING

         Any proposal that a  stockholder  intends to present at the 2000 Annual
Meeting of Stockholders must be submitted to the Secretary of the Company at its
offices, 155 Fortune Blvd., Milford,  Massachusetts 01757, no later than January
8, 2000 in order to be considered for inclusion in the Proxy Statement  relating
to that meeting.


                                  OTHER MATTERS

         The  Board  of  Directors  knows  of no other  business  which  will be
presented for  consideration  at the Annual  Meeting  other than that  described
above.  However, if any other business should come before the Annual Meeting, it
is the  intention  of the  persons  named in the  enclosed  Proxy  to  vote,  or
otherwise act, in accordance with their best judgment on such matters.

         The Company will bear the costs of soliciting  proxies.  In addition to
solicitations by mail, the Company's  directors,  officers and regular employees
may, without additional remuneration,  solicit proxies by telephone,  telegraph,
facsimile  and personal  interviews.  The Company  will also  request  brokerage
houses,  custodians,  nominees and  fiduciaries  to forward  copies of the proxy
material to those persons for whom they hold shares and request instructions for
voting the proxies.  The Company will reimburse such brokerage  houses and other
persons for their reasonable expenses in connection with this distribution.


         THE BOARD OF DIRECTORS HOPES THAT  STOCKHOLDERS  WILL ATTEND THE ANNUAL
MEETING.  WHETHER OR NOT YOU PLAN TO ATTEND,  YOU ARE URGED TO  COMPLETE,  DATE,
SIGN AND RETURN THE ENCLOSED PROXY IN THE ACCOMPANYING ENVELOPE. PROMPT RESPONSE
WILL GREATLY FACILITATE ARRANGEMENTS FOR THE ANNUAL MEETING AND YOUR COOPERATION
IS APPRECIATED.  STOCKHOLDERS WHO ATTEND THE ANNUAL MEETING MAY VOTE THEIR STOCK
PERSONALLY EVEN THOUGH THEY HAVE SENT IN THEIR PROXIES.

                                            By Order of the Board of Directors,



                                            Cheryl M. Northrup, Secretary
April 30, 1999


                                       28

<PAGE>

                                    EXHIBIT A

                                 HYBRIDON, INC.
                           --------------------------

                            1997 STOCK INCENTIVE PLAN
                           --------------------------

AMENDMENT NO. 2 TO THE 1997 STOCK INCENTIVE PLAN OF HYBRIDON, INC.

         The first sentence of Subsection  4(a) of the 1997 Stock Incentive Plan
of  Hybridon,  Inc.  will be amended and  restated in its entirety to provide as
follow, subject to stockholder approvals:

         "Subject to adjustment under  subsection (c) below,  Awards may be made
under the Plan for up to 6,500,000 shares of Common Stock."


                                            Adopted by the Board of Directors on
                                            February 22, 1999

                                            Approved   by  the stockholders of
                                            the   Company   on June __, 1999.


                                       29


<PAGE>

                                    EXHIBIT B

                                 HYBRIDON, INC.
                                 --------------

                         1995 DIRECTOR STOCK OPTION PLAN
                         -------------------------------


AMENDMENT NO. 1 TO THE 1995 DIRECTOR STOCK OPTION PLAN OF HYBRIDON, INC.

         Subsection  4(a) of the 1995 Director  Stock Option Plan (the "Director
Plan") of Hybridon,  Inc. will be amended and restated in its entirety,  subject
to stockholder approval as follows:

                  "(a) The  maximum  number of shares  of the  Company's  Common
         stock  ("Common  Stock"),  which may be issued  under the Plan shall be
         400,000 shares, subject to adjustment as provided in Section 7."


         Subsection  5(a)  of  the  Director  Plan  is  hereby  amended  to  add
subsections (iv) and (v), subject to stockholder approval as follows:

                  "(iv) each person who is an eligible  outside director on June
         8, 1999  shall be  granted an option to  purchase  8,000  shares of the
         Company's Common Stock on June 8, 1999.

                  (v)  notwithstanding  any prior interpretation of the formula
         in subsection (a) of this section by reason of the one-for-five reverse
         stock split with respect to the Common Stock effected in December 1997,
         it is hereby confirmed that the grant to each eligible outside director
         referred  to in  subsection  (a) of this  section  shall  be a grant to
         purchase 5,000 shares of Common Stock."


         Subsection  5(d)(i) of the Director Plan is hereby amended and restated
in its entirety, subject to stockholder approval, as follows:

                  "(i) General.  Each option  described in clauses (i), (ii) and
         (iv) of Section 5(a) shall become  exercisable on the first anniversary
         of the Option Grant Date,  and each option  described in clauses  (iii)
         and (v) of Section  5(a) shall become  exercisable  on the day prior to
         the first anniversary of the Option Grant Date; provided, however, that
         in each instance  described herein the optionee continues to serve as a
         director on such dates."

                                          Adopted by the Board of Directors on
                                          February 22, 1999

                                          Approved   by  the stockholders of
                                          the   Company   on June __, 1999.


                                       30


<PAGE>

This Proxy when properly  executed  will be voted in the manner  directed by the
undersigned  stockholder(s).  If no other  indication is made, the proxies shall
vote "FOR" proposed numbers 1,2,3 and 4.


Please mark [X]
your votes as indicated in this
example


1)  Election of Class I Directors.

                           For  All
For      Withhold          Except
[  ]     [   ]              [  ]

Nominees:  Nasser Menhall, Arthur W. Berry and Harold
L. Purkey.

If you do not wish your shares voted "FOR" a particular  nominee,  mark the "For
All Except" box and strike a line through the nominee(s)  name. Your shares will
be voted for the  remaining  nominee(s).  

2)  Approval of the  amendment  to the
Company's 1997 Stock Incentive Plan.

For      Against   Abstain
[  ]     [   ]     [  ]

3)  Approval of the amendment to the
Company's 1995 Director Stock Option
Plan.

For      Against  Abstain
[  ]     [  ]     [   ]

4) Ratification  of selection of Arthur Andersen LLP as independent  auditors of
the Company for the current year.

For      Against  Abstain
[  ]     [   ]    [   ]

A vote  FOR  the  director  nominees  and  FOR  proposal  numbers  2,3  and 4 is
recommended by the Board of Directors.

Mark this box at right if  comments  or  address  change  have been noted on the
reverse side of this card.

Please be sure to sign and date this Proxy.

Please sign this proxy exactly as your name appear  hereon.  Joint Owners should
each  sign  personally.  Trustees  and other  fiduciaries  should  indicate  the
capacity in which they sign.  If a  corporation  or  partnership,  the signature
should be that of an authorized officer who should state his or her title.

Date:___________________


________________________
Stockholder Signature

PLEASE VOTE, DATE AND SIGN ON
OTHER SIDE AND RETURN
PROMPTLY IN ENCLOSED
ENVELOPE



<PAGE>


                                 HYBRIDON, INC.

Dear Stockholder:

Please take note of the important  information  enclosed with this Proxy Ballot.
There are a number of issues  related to the  management  and  operation of your
Company that require you immediate  attention and approval.  These are discussed
in the enclosed proxy materials.

Your vote counts, and you are strongly encouraged to exercise your right to vote
your shares.

Please  mark the boxes on the proxy card to indicate  how your  shares  shall be
voted.  Then sign and date the card, detach it and return your proxy vote in the
enclosed postage paid envelope.

Your vote must be received  prior to the Annual  Meeting of  Stockholders  to be
held on June 8, 1999.

Thank you in advance for your prompt consideration of these matters.

Sincerely,


Hybridon, Inc.

                                 HYBRIDON, INC.

                         PROXY SOLICITED BY THE BOARD OF
                           DIRECTORS Annual Meeting of
                           Stockholders - June 8, 1999

Those signing on the reverse side, revoking prior proxies,  hereby appoint(s) E.
Andrews  Grinstead,  III, Robert G. Andersen and Cheryl M. Northrup,  or each or
any of them with full power of substitution, as proxies for those signing on the
reverse  side to act and  vote  all  shares  of stock  of  Hybridon,  Inc.  (the
"Company") which the undersigned would be entitled to vote if personally present
at  the  1999  Annual  Meeting  of  Stockholders  of  the  Company  and  at  any
adjournments  thereof as indicated  upon all matters  referred to on the reverse
side and  described  in the  Proxy  Statement  for the  Meeting,  and,  in their
discretion,  upon any other  matters which may properly come before the Meeting.
Attendance of the undersigned at the Meeting or at any adjournment  thereof will
not be deemed to revoke this proxy  unless  those  signing on the  reverse  side
shall revoke this proxy in writing.

         HAS YOUR ADDRESS CHANGED?                 DO YOU HAVE ANY COMMENTS?


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