HYBRIDON INC
10-Q/A, 1999-01-04
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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    As filed with the Securities and Exchange Commission on January 4, 1999
    -------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   FORM 10-Q/A
                                (Amendment No. 1)

                        QUARTERLY REPORT UNDER SECTION 13
                 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

                                     -------


For the Quarter Ended:  September 30, 1998       Commission File Number 0-27352

                                 Hybridon, Inc.
                                 --------------
             (Exact name of registrant as specified in its charter)


           Delaware                                  04-3072298
           --------                                  ----------
(State or other jurisdiction of        (I.R.S. Employer Identification Number)
organization or incorporation)

                                155 Fortune Blvd.
                                Milford, MA 01757
                                -----------------
          (Address of principal executive offices, including zip code)


                                 (508) 482-7500
                                 --------------
              (Registrant's telephone number, including area code)


Indicate by check mark  whether the  registrant  (1) has filed all reports to be
filed by Section 13 or 15(d) of the  Securities  Exchange Act of 1934 during the
preceding 12 months (or for such shorter period that the registrant was required
to file such reports),  and (2) has been subject to such filing requirements for
the past 90 days.

                                    YES  X    NO 
                                        ---      ---

Indicate the number of shares  outstanding  of each of the  issuer's  classes of
common stock, as of the latest practicable date.

Common Stock, par value $.001 per share                  15,306,825
- ---------------------------------------               ----------------
                 Class                       Outstanding as of December 31, 1998





<PAGE>

                                 HYBRIDON, INC.

                                    Form 10-Q/A

                                      INDEX


Part I - Financial Information
- ------------------------------

Item 1 - Financial Statements

        Consolidated Condensed Balance Sheets as of September 30, 1998 and
           December 31, 1997.

        Consolidated  Condensed  Statements of  Operations  for the Three Months
           ended  and  Nine  Months  ended  September  30,  1998  and  1997  and
           Cumulative from May 25, 1989 (Inception) to September 30, 1998

        Consolidated  Condensed  Statements  of Cash  Flows for the Nine  Months
           ended  September 30, 1998 and 1997 and  Cumulative  from May 25, 1989
           (Inception) to September 30, 1998

        Notes to Consolidated Condensed Financial Statements


Item 2 - Management's Discussion and Analysis of
           Financial Condition and Results of Operations

Part II - Other Information
- ---------------------------

Items 1 through 4 -   None

Item 5 - Other Information

Item 6 - Exhibits and Reports on Form 8-K

Signatures





<PAGE>
                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)
                      CONSOLIDATED CONDENSED BALANCE SHEETS
                                   (UNAUDITED)

                                     ASSETS
<TABLE>
<CAPTION>

                                                                                 September 30,   December 31,
                                                                                      1998           1997
<S>                                                                             <C>            <C>    

     CURRENT ASSETS:
     Cash and cash equivalents                                                      $   882,825    $ 2,202,202
     Accounts receivable                                                                825,668        529,702
     Accounts receivable related to real estate limited partnership                   5,450,000              -
     Prepaid expenses and other current assets                                          448,372      1,005,825
                                                                                    -----------    -----------


     Total current assets                                                             7,606,865      3,737,729
                                                                                    -----------    -----------


     PROPERTY AND EQUIPMENT, NET                                                      8,953,117     19,230,804
                                                                                    -----------    -----------


     OTHER ASSETS:
     Restricted cash                                                                    659,618      3,050,982
     Notes receivable from officers                                                     255,800        247,250
     Deferred financing costs and other assets                                          923,162      3,354,767
     Investment in real estate partnership                                                    -      5,450,000
                                                                                    -----------    -----------



                                                                                      1,838,580     12,102,999
                                                                                    -----------    -----------


                                                                                    $18,398,562    $35,071,532
                                                                                    -----------    -----------






                                  LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)

      CURRENT LIABILITIES:
      Current portion of long-term debt and capital lease obligations                 3,030,981      7,868,474
      Accounts payable                                                                4,387,353      8,051,817
      Accrued expenses                                                                3,003,934     11,917,298
                                                                                    -----------    -----------
      Total current liabilities                                                      10,422,268     27,837,589
                                                                                    -----------    -----------


      LONG-TERM DEBT AND CAPITAL LEASE OBLIGATIONS, NET OF CURRENT PORTION              573,017      3,282,123
                                                                                    -----------    -----------
      9% CONVERTIBLE SUBORDINATED NOTES PAYABLE                                       1,306,000     50,000,000
                                                                                    -----------    -----------


      STOCKHOLDERS' EQUITY(DEFICIT):
      Preferred stock, $.01 par value-
      Authorized--5,000,000 shares
      Issued and outstanding--None                                                            -              -

      Series A convertible preferred stock, $.01 par value-
      Authorized--5,000,000 shares
      Issued and outstanding--624,790 shares at September 30, 1998                        6,248              -
      Common stock, $.001 par value-
      Authorized--100,000,000 shares
      Issued and outstanding--15,254,825 and 5,059,650 shares at
      September  30, 1998, and  December 31, 1997, respectively                          15,255          5,060
      Additional paid-in capital                                                    240,301,274    173,695,698
      Deficit accumulated during the development stage                             (233,294,707)  (218,655,101)
      Deferred compensation                                                            (930,793)    (1,093,837)
                                                                                    -----------    -----------


      Total stockholders' equity(deficit)                                             6,097,277    (46,048,180)
                                                                                    -----------    -----------
                                                                                     18,398,562     35,071,532
                                                                                    ===========    ===========


</TABLE>

The  accompanying  notes are an integral  part of these  consolidated  condensed
financial statements.


<PAGE>


                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)

                 CONSOLIDATED CONDENSED STATEMENTS OF OPERATIONS

                                   (UNAUDITED)


<TABLE>
<CAPTION>

                                                                                                       Cumulative
                                                                                                          from
                                                                                                      May 25, 1989
                                    Three Months Ended              Nine Months Ended                (Inception) to
                                      September 30,                  September 30,                    September 30,
<S>                                                 <C>           <C>               <C>             <C>    

                                          1998            1997            1998            1997            1998
REVENUES:
Research and development                $   150,000    $    200,000    $    949,915    $    980,150   $   6,449,178
Product and service revenue                 846,746         155,368       2,353,435       1,231,226       5,310,472
Interest income                              44,010         294,246         106,457         898,160       3,327,196
Royalty and other income                          -          18,247               -          33,218         110,321
                                        -----------    ------------    ------------    ------------   -------------
                                          1,040,756         667,861       3,409,807       3,142,754      15,197,167
                                        -----------    ------------    ------------    ------------   -------------


OPERATING EXPENSES:
Research and development                  5,201,246      11,338,913      17,180,927      37,784,718     182,640,742
General and administrative                1,503,845       3,057,380       5,217,864       9,011,879      53,034,480
Restructuring charge                              -       3,100,000               -       3,100,000      11,020,000
Interest                                    296,344       1,605,918       2,880,307       3,223,473       9,026,337
                                        -----------    ------------    ------------    ------------   -------------
                                          7,001,435      19,102,211      25,279,098      53,120,070     255,721,559
                                        -----------    ------------    ------------    ------------   -------------
Loss from operations                     (5,960,679)    (18,434,350)    (21,869,291)    (49,977,316)   (240,524,392)

EXTRAORDINARY ITEM:
Gain on conversion of 9%                          -               -       8,876,685               -       8,876,685
                                        -----------    ------------    ------------    ------------   -------------
convertible subordinated notes

NET LOSS                                 (5,960,679)    (18,434,350)    (12,992,606)    (49,977,316)   (231,647,707)
                                        -----------    ------------    ------------    ------------   -------------


ACCRETION OF PREFERRED                    1,647,000               -       1,647,000               -       1,647,000
                                        -----------    ------------    ------------    ------------   -------------
STOCK DIVIDEND

NET LOSS TO COMMON                      $(7,607,679)   $(18,434,350)   $(14,639,606)   $(49,977,316)  $(233,294,707)
                                        ===========    ============    ============    ============   =============
STOCKHOLDERS                                                                                          



BASIC AND DILUTED LOSS
PER COMMON SHARE  FROM
(Note 3):

    OPERATIONS, INCLUDING               $     (0.50)   $      (3.65)   $      (2.21)   $      (9.90)
    ACCRECTION OF PREFERRED
    STOCK

    EXTRAORDINARY GAIN                                                                
                                                  -               -            0.83               -
                                        -----------    ------------    ------------    ------------   


    NET LOSS                            $     (0.50)   $      (3.65)   $      (1.37)   $      (9.90)
                                        ===========    ============    ============    ============



SHARES USED IN COMPUTING BASIC AND
DILUTED NET LOSS PER COMMON SHARE
(Note 3)                                 15,254,825       5,055,513      10,648,116       5,046,806
                                        ===========    ============    ============    ============

</TABLE>



The  accompanying  notes are an integral  part of these  consolidated  condensed
financial statements


<PAGE>

                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)

                 CONSOLIDATED CONDENSED STATEMENTS OF CASH FLOWS

                                   (UNAUDITED)

<TABLE>
<CAPTION>

                                                                                              Cumulative
                                                                                                 from
                                                                                             May 25, 1989
                                                                     Nine Months Ended      (inception) to
                                                                       September 30,         September 30,
<S>                                                                        <C>            <C>            

                                                                   1998           1997           1998

         CASH FLOWS FROM OPERATING ACTIVITIES:
         Net loss                                             $(12,992,606)   $(49,977,316) $(231,647,707)
         Adjustments  to  reconcile  net  loss to net  cash  
         used  in  operating activities--
         Extraordinary gain on conversion of 9% convertible
           subordinated notes payable                            (8,876,685)             -     (8,876,685)
         Depreciation and amortization                            2,419,269      4,081,720     13,605,723
         Loss on disposal of fixed assets                           424,675              -        424,675
         Issuance of common stock for services rendered           1,195,398        146,875      1,342,273
         Compensation on grant of stock options, warrants
         and                                                        163,044        261,519      8,286,842
            restricted stock
         Amortization of discount on convertible promissory
         notes                                                            -              -        690,157
            payable
         Amortization of deferred financing costs                   240,611        358,904        937,080
         Noncash interest on convertible promissory notes                 -              -        260,799
         payable
         Write-down of assets related to restructuring            6,600,000        331,000      7,200,000
         Changes in operating assets and liabilities-
           Accounts receivable                                     (295,966)       276,545       (825,668)
           Prepaid and other current assets                         557,703       (541,718)      (448,122)
           Notes receivable from officers                            (8,550)        55,952       (255,800)
           Amounts payable to related parties                             -              -       (200,000)
           Accounts payable and accrued expenses                 (6,871,326)     3,349,962     13,097,789
           Deferred revenue                                               -        (86,250)             -
                                                               ------------   ------------  -------------
         Net cash used in operating activities                  (17,444,433)   (41,742,807)  (196,408,644)
                                                               ------------   ------------  -------------


         CASH FLOWS FROM INVESTING ACTIVITIES:
         Increase in short-term investments                               -     (5,113,569)             -
         Purchases of property and equipment, net                  (340,507)    (6,645,439)   (29,652,972)
         Proceeds from sale of fixed assets                         460,000              -        460,000
         Investment in real estate partnership                            -              -     (5,450,000)
                                                               ------------   ------------  -------------
         Net cash provided by (used in) investing activities        119,493    (11,759,008)   (34,642,972)
                                                               ------------   ------------  -------------


         CASH FLOWS FROM FINANCING ACTIVITIES:
         Proceeds from issuance of convertible preferred stock    6,804,562              -    103,388,716
         Proceeds from issuance of common stock related to
         stock                                                            -         83,327      1,260,928
           options and restricted stock grants
         Proceeds from issuance of common stock related to
         stock                                                            -          9,075      3,185,816
           warrants
         Net proceeds from issuance of common stock               6,876,676              -     59,232,000
         Repurchase of common stock                                       -              -           (263)
         Proceeds from notes payable                                      -              -      9,450,000
         Proceeds from issuance of convertible promissory
         notes                                                    4,233,832     50,000,000     63,425,576
           payable
         Proceeds from long-term debt                                     -              -        662,107
         Payments on long-term debt and capital leases           (4,236,693)    (1,169,656)    (7,602,573)
         Proceeds from sale/leaseback                                     -      1,165,236      4,001,018
         Decrease (increase)  in restricted cash and other        2,327,186       (626,985)    (1,811,945)
         assets
         (Increase) decrease in deferred financing costs                  -     (2,699,957)    (3,256,939)
                                                               ------------   ------------  -------------
         Net cash provided by financing activities               16,005,563     46,761,040    231,934,441
                                                               ------------   ------------  -------------


         NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS    (1,319,377)    (6,740,775)       882,825

         CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD           2,202,202     12,633,742              -
                                                               ------------   ------------  -------------

         CASH AND CASH EQUIVALENTS, END OF PERIOD              $    882,825   $  5,892,967  $     882,825
                                                               ============   ============  ==============


         SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION:
         Cash paid for interest                                $  1,494,323   $   786,005   $   5,124,773
                                                               ============   ============  =============

</TABLE>


The  accompanying  notes are an integral  part of these  consolidated  condensed
financial statements.


                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)
              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)

(1)     ORGANIZATION

Hybridon,  Inc. (the "Company") was incorporated in the State of Delaware on May
25,  1989.  The Company is engaged in the  discovery  and  development  of novel
genetic medicines based primarily on antisense technology. The Company is in the
development  stage.  Since inception,  the Company has been engaged primarily in
research and development efforts,  development of its manufacturing capabilities
and organizational  efforts,  including  recruiting of scientific and management
personnel and raising  capital.  To date,  the Company has not received  revenue
from the sale of  biopharmaceutical  products developed by it based on antisense
technology. In order to commercialize its own products, the Company will need to
address a number of  technological  challenges  and  comply  with  comprehensive
regulatory requirements.  Accordingly,  it is not possible to predict the amount
of funds that will be  required  or the length of time that will pass before the
Company receives revenues from sales of any of these products. Revenues received
by  the  Company  to  date  have  been  derived  primarily  from   collaboration
agreements,  interest on investment  funds,  revenues  from the custom  contract
manufacturing  of synthetic DNA and reagent  products by the Company's  Hybridon
Specialty  Products  Division.  As a result,  although  the Company has begun to
generate revenues from its custom contract  manufacturing  business, the Company
is dependent on the proceeds  from possible  future sales of equity  securities,
debt  financings and research and  development  collaborations  in order to fund
future operations.

On May 5, 1998, the Company  completed a private  offering of equity  securities
raising total gross proceeds of approximately $27.3 million from the issuance of
9,597,476  shares  of common  stock,  114,285  shares  of  Series A  convertible
preferred  stock and  warrants to purchase  2,657,219  shares of common stock at
$2.40 per share. The gross proceeds include the conversion of approximately $6.2
million of accounts  payable,  capital lease  obligations and other  obligations
into common  stock.  The Company  incurred  approximately  $2.6  million of cash
expenses  related to the private  offering and issued  597,699  shares of common
stock and  warrants to purchase  1,720,825  shares of common  stock at $2.40 per
share to the placement agents.  The compensation  received by Pillar Investments
Ltd.  ("Pillar"),  a company  affiliated with certain  directors of the Company,
with respect to the offshore  component of the private  offering (the  "Offshore
Offering")  consisted of (i) 9% of gross proceeds of such Offshore  Offering and
(ii) a  non-accountable  expense allowance equal to 4% of gross proceeds of such
Offshore  Offering.  Pillar received  approximately $1.6 million and warrants to
purchase 1,111,630 shares of common stock at $2.40 per share.

On February 6, 1998,  the Company  commenced an exchange offer to the holders of
the 9% Convertible  Subordinated Notes (the "9% Notes") (see Note 6) to exchange
the 9% Notes for Series A convertible  preferred  stock and certain  warrants of
the Company. On May 5, 1998,  noteholders holding $48.7 million of principal and
$2,361,850 of accrued  interest  tendered such principal and accrued interest to
the Company  for  510,505  shares of Series A  convertible  preferred  stock and
warrants to purchase  3,002,958 shares of common stock with an exercise price of
$4.25 per share. In accordance with Statement of Financial  Accounting  ("SFAS")
No.15, Accounting by Debtors and Creditors for Troubled Debt Restructurings, the
Company recorded an extraordinary  gain of approximately $8.9 million related to
the conversion.  The  extraordinary  gain represents the difference  between the
carrying  value of the 9% Notes and the fair value of the  Series A  convertible
preferred  stock,  as  determined  by the per  share  sales  price  of  Series A
convertible  preferred stock sold in the private  offering  described above, and
warrants to purchase common stock issued by the Company.





<PAGE>

                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)
              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)

(2)     UNAUDITED INTERIM FINANCIAL STATEMENTS

The unaudited  consolidated  condensed financial statements included herein have
been  prepared  by  the  Company,  without  audit,  pursuant  to the  rules  and
regulations  of the  Securities  and Exchange  Commission  and  include,  in the
opinion  of  management,  all  adjustments,   consisting  of  normal,  recurring
adjustments,  necessary  for a fair  presentation  of  interim  period  results.
Certain  information  and footnote  disclosures  normally  included in financial
statements prepared in accordance with generally accepted accounting  principles
have been  condensed  or omitted  pursuant  to such rules and  regulations.  The
Company  believes,  however,  that  its  disclosures  are  adequate  to make the
information  presented  not  misleading.  The results  for the  interim  periods
presented are not necessarily  indicative of results to be expected for the full
fiscal  year.  It is  suggested  that  these  financial  statements  be  read in
conjunction with the audited consolidated financial statements and notes thereto
included in the Company's Annual Report on Form 10-K for the year ended December
31, 1997, as filed with the Securities and Exchange Commission.

(3)     SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Net Loss per Common Share
The Company applies SFAS No. 128,  Earnings per Share,  in calculating  earnings
per share.  Basic net loss per share is computed by dividing net loss applicable
to common  stockholders (net loss plus cumulative  preferred stock dividends) by
the weighted  average  number of common  shares  outstanding  during the period.
Diluted  net loss per share for the periods  presented  is the same as basic net
loss per share as the inclusion of the potential common stock  equivalents would
be  antidilutive.  Antidilutive  securities  which  consist of stock options and
warrants  that are not  included  in  diluted  net loss per  common  share  were
12,568,143 and 2,686,863 for the nine month periods ended September 30, 1998 and
1997, respectively.

(4)     CASH EQUIVALENTS

The Company applies SFAS No. 115, Accounting for Certain Investments in Debt and
Equity Securities.  Under SFAS No. 115, debt securities that the Company has the
positive  intent and ability to hold to maturity are recorded at amortized  cost
and are classified as held-to-maturity securities. These securities include cash
equivalents and restricted cash. Cash  equivalents  have original  maturities of
less than three  months.  Cash and cash  equivalents  at September  30, 1998 and
December 31, 1997 consisted of the following:

                                              September 30,       December 31,
                                                   1998               1997
    Cash and cash equivalents
       Cash and money market funds            $      400,949  $       1,702,272
       Corporate bond                                481,876            499,930
                                              --------------  -----------------

                                              $      882,825  $       2,202,202
                                              ==============  =================
    Restricted cash - long-term
       Certificates of deposit                $            -   $      2,016,364
       Savings account                               659,618          1,034,618
                                              --------------  -----------------

                                              $      659,618    $     3,050,982
                                              ==============  =================







<PAGE>

                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)
              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)


(5)     ACCOUNTS RECEIVABLE RELATED TO REAL ESTATE LIMITED PARTNERSHIP

Under the terms of the Cambridge,  Massachusetts  building lease (the "Cambridge
Lease"),  the Company  accounted for $5,450,000 of its payments for a portion of
the costs of construction of the leased premises as contributions to the capital
of the Cambridge landlord in exchange for a limited partnership  interest in the
Cambridge  landlord  (the  "Partnership  Interest").  Under  the  terms  of  the
Partnership  Interest,  the  Company has the right at any time prior to February
2000 to sell the Partnership  Interest back to the other limited partners of the
landlord.  In April  1998,  the  Company  exercised  its  right to sell back the
Partnership  Interest  and  accordingly  the  contribution  to the  real  estate
partnership  has been  classified  as a current  asset at  September  30,  1998.
Subsequent to September 30, 1998, the sale of the building was finalized and the
Company received payment in November 1998.

(6)     9.0% CONVERTIBLE SUBORDINATED NOTES

On April 2, 1997, the Company issued  $50,000,000 of the 9% Notes.  As discussed
in Note 1, on May 5, 1998  noteholders  holding $48.7 million of principal value
of the 9%  Notes  tendered  such  notes in  exchange  for  Series A  convertible
preferred stock and warrants to purchase  common stock. In addition,  $2,361,850
of accrued  interest  thereon was converted  into shares of Series A convertible
preferred stock and warrants to purchase common stock. As of September 30, 1998,
there is $1.3 million principal amount of 9% Notes outstanding.  Under the terms
of the 9% Notes,  the Company  must make  semi-annual  interest  payments on the
outstanding principal balance through the maturity date of April 1, 2004. If the
9% Notes are converted  prior to April 1, 2000, the  Noteholders are entitled to
receive  accrued  interest  from the date of the most  recent  interest  payment
through the conversion date. The 9% Notes are subordinate to  substantially  all
of the Company's existing indebtedness. The 9% Notes are convertible at any time
prior to the maturity  date at a  conversion  price equal to $35.0625 per share,
subject to adjustment under certain circumstances, as defined.

Beginning April 1, 2000, the Company may redeem the 9% Notes at its option for a
4.5% premium over the original issuance price,  provided that from April 1, 2000
to March 31, 2001, the 9% Notes may not be redeemed  unless the closing price of
the common stock equals or exceeds 150% of the conversion  price for a period of
at least 20 out of 30 consecutive  trading days and the 9% Notes redeemed within
60 days after such  trading  period.  The  premium  decreases  by 1.5% each year
through March 31, 2003. Upon a change of control of the Company, as defined, the
Company  will be  required  to offer to  repurchase  the 9% Notes at 150% of the
original issuance price.

(7)     NEW ACCOUNTING STANDARDS

Effective  January  1,  1998,  the  Company  adopted  SFAS  No.  130,  Reporting
Comprehensive  Income.  SFAS No. 130 requires  disclosure  of all  components of
comprehensive  income on an annual and interim  basis.  Comprehensive  income is
defined as the change in equity of a business  enterprise  during a period  from
transactions  and other events and  circumstances  from non-owner  sources.  The
Company's  total  comprehensive  net loss for the three and nine  month  periods
ended  September  30, 1998 and 1997 were the same as reported net loss for those
periods.

In July 1997,  the FASB issued SFAS No. 131,  Disclosures  About  Segments of an
Enterprise and Related Information.  SFAS No. 131 requires certain financial and
supplementary  information  to be disclosed  on an annual and interim  basis for
each reportable  segment of an enterprise.  SFAS No. 131 is effective for fiscal
years beginning after December 15, 1997. Unless  impracticable,  companies would
be required to restate prior period information




<PAGE>

                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)
              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)

upon adoption.  The Company  believes that the adoption of SFAS No. 131 will not
have a material impact on its financial results or financial position.

(8)     RESTRUCTURING

Beginning in July 1997, the Company  implemented a restructuring  plan to reduce
expenditures on a phased basis over the balance of 1997 in an effort to conserve
its cash resources.  As a part of this restructuring  plan, the Company recorded
an $11,020,000  restructuring  charge in 1997 to provide for (i) the termination
of certain research programs,  (ii) the abandonment of certain leased facilities
(net of sublease income and related  disposal of fixed assets),  (iii) severance
obligations  to nearly 100  terminated  employees and (iv) the  cancellation  of
certain other contracts. During the third quarter of 1998, the Company completed
its  restructuring  plan after  moving its  corporate  headquarters  to Milford,
Massachusetts.


(9)     NOTE PAYABLE TO A BANK

In December 1996, the Company  entered into a five year  $7,500,000 note payable
with a bank.  The note contains  certain  financial  covenants  that require the
Company  to  maintain  minimum  tangible  net worth and  minimum  liquidity  and
prohibits the payment of dividends. The note is payable in 59 equal installments
of $62,500  commencing  on February  1, 1997 with a balloon  payment of the then
remaining outstanding principal balance due on January 1, 2002. During 1997, the
Company's minimum liquidity had fallen below the required amount and the Company
deposited $1,758,542 as collateral under the cash pledge agreement. During 1998,
the bank withdrew the full amount of the restricted  cash and applied it against
the outstanding  balance of the note. The minimum  liquidity  requirements  were
subsequently amended to provide that if as of the fifteenth and last day of each
calendar  month  the  Company  does  not  have  minimum  liquidity  of at  least
$4,000,000, as defined, the Company will be required to immediately repay to the
bank 100% of the then outstanding balance. As of September 30, 1998,  $2,895,000
was outstanding  under the note,  which is classified as a current  liability in
the accompanying  September 30, 1998 consolidated  balance sheet.  During August
1998, the Company placed $1.6 million in escrow at the bank's request, which was
withdrawn and applied against the  outstanding  balance of the note by the bank.
Also, upon the closing of the sale of the Partnership  Interest (see Note 5) the
Company was required to pay down an additional $750,000 on the note. The Company
is also required to pay to the bank  one-half of any proceeds  received from the
sale of certain assets.  The Company intends to make payments  relating to these
items  to the  bank  during  November  1998 in the  event  that  the Loan is not
purchased as described in Note 13. On September 29, 1998, the Company received a
waiver of noncompliance since the Company was not in compliance with the minimum
liquidity and minimum  tangible net worth  covenants  associated  with the note.
Following the sale of the  partnership  interest,  the Company was in compliance
with all such covenants.

(10)    METHYLGENE, INC. LICENSING AGREEMENT

In January 1996, the Company and  MethylGene,  Inc.  ("MethylGene")  (a Canadian
company  which  is  approximately  30%  owned  by the  Company)  entered  into a
licensing agreement for the purpose of researching and developing  compounds for
the treatment of cancer and other  indications.  In May 1998, this agreement was
amended to grant  MethylGene a non-exclusive  right to use any and all antisense
chemistries  discovered  by the  Company or any of its  affiliates  for a period
commencing on May 5, 1998 and ending on the earlier of (i) the effective date of
termination  by  MethylGene  of its  contract  for  development  services  to be
provided by the  Company,  (ii) May 5, 1999,  unless  MethylGene  exercises  its
option to continue contracting for development services, or (iii) May 5, 2000.




<PAGE>

                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)
              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)

As additional consideration for this non-exclusive right, MethylGene is required
to pay the Company certain milestone amounts,  as defined,  and transfer 300,000
shares of MethylGene's class B shares to the Company.  The Company has placed no
value on these  shares.  In the third  quarter  of 1998,  the  Company  recorded
$250,000 of revenue received from MethylGene.

(11)    UNITS ISSUED TO PRIMEDICA CORPORATION

The Company has issued  250,000  shares of common  stock and 62,500  warrants to
purchase common stock to Primedica  Corporation  ("Primedica")  for $250 in cash
and future  services  to be  provided.  The  services  shall  commence  upon the
Company's request after (i) the Company's  securities are listed on a nationally
recognized exchange,  and (ii) the average closing price of the Company's common
stock is at least  $2.00 per share for the twenty day trading  period  preceding
the contract commencement date. In the event that the Company does not use these
services as a result of the failure to meet the contract  conditions,  Primedica
may forfeit to the Company all or part of the common stock and warrants  held by
Primedica.  The Company has recorded  these shares as issued and  outstanding at
September  30, 1998 at par value.  The Company  will record an expense for these
services as the services are provided.

(12)    SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION

The  accompanying   consolidated  financial  statements  include  the  following
information:

<TABLE>
<CAPTION>

                                                                                                        Cumulative from
                                                                                                          May 25, 1989
                                                                            Nine Months Ended            (Inception) to
                                                                              September 30,              September 30,
                                                                           1998              1997              1998
<S>                                                                                  <C>             <C>    

SUPPLEMENTAL DISCLOSURE OF NONCASH FINANCING
ACTIVITIES:

  Issuance of Series A convertible preferred stock in 
  exchange for conversion of 9% convertible subordinated 
  notes payable and accrued interest                                      $51,061,850  $        -         $ 51,061,850

  Accretion of Series A convertible preferred stock dividends             $ 1,647,000  $        -         $  1,647,000

  Issuance of common stock in exchange for conversion of
  convertible subordinated notes payable                                  $ 4,800,000  $        -         $  4,800,000

  Issuance  of common  stock in exchange for conversion of 
  accounts  payable, capital lease obligations and accrued 
  interest
                                                                          $ 6,434,308  $        -         $  6,434,308
  Issuance of common stock for services rendered                          $ 1,195,398  $        -         $  1,342,272


</TABLE>


<PAGE>

                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)
              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)


(13)    SUBSEQUENT EVENT

Subsequent to September 30, 1998, Forum Capital Markets, LLC ("Forum") and Pecks
Management Partners Ltd. ("Pecks"; Forum and Pecks collectively,  the "Lender"),
affiliates  of two  members  of the  Company's  Board of  Directors,  agreed  to
purchase the Company's note payable to the bank (see Note 9). In connection with
this purchase,  the Lender will lend an additional amount to the Company as soon
as practicable so as to increase the  outstanding  principal  amount of the note
payable  to  $6,000,000.  In  addition,  the terms of the note  payable  will be
amended as follows: (i) the maturity will be extended to November 30, 2003; (ii)
the  interest  rate will be  decreased  to 8%;  (iii)  interest  will be payable
monthly in  arrears,  with the  principal  due in full at  maturity  of the note
payable;  (iv) the note payable will be convertible,  at the Lender's option, in
whole or in part, into shares of common stock of the Company;  (v) the threshold
of the minimum liquidity covenant will be reduced from $4,000,000 to $2,000,000;
and (vi) the note payable may not be prepaid,  in whole or in part,  at any time
prior to  December  1, 2000.  The other  terms of the note  payable  will remain
unchanged.  In  connection  with the  purchase of the note  payable,  Forum will
receive a fee of $400,000,  which will be reinvested by Forum by purchasing from
the  Company  common or  preferred  stock and  warrants,  and will also  receive
warrants to purchase $400,000 of shares of common stock of the Company.




<PAGE>

Item 2. MANAGEMENT'S  DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
        OF OPERATIONS

The Company is engaged in the discovery  and  development  of genetic  medicines
based on antisense technology. The Company commenced operations in February 1990
and since that time has been  engaged  primarily  in  research  and  development
efforts,  development  of  its  manufacturing  capabilities  and  organizational
efforts,  including  recruitment  of scientific and  management  personnel,  and
raising capital.  To date, the Company has not received revenue from the sale of
biopharmaceutical  products  developed by it. In order to commercialize  its own
products, the Company will need to address a number of technological  challenges
and comply with comprehensive  regulatory requirements.  Accordingly,  it is not
possible  to predict  the amount of funds that will be required or the length of
time that will pass before the Company  receives  revenues  from sales of any of
these products.  All revenues  received by the Company to date have been derived
from  collaborative  and service  agreements,  interest  on  invested  funds and
revenues  from the custom  contract  manufacturing  of synthetic DNA and reagent
products by the Hybridon Specialty Products ("HSP") Division.

The Company has incurred  cumulative losses from inception through September 30,
1998 of  approximately  $231.6 million.  In the second half of 1997, the Company
commenced a restructuring  program that has significantly  reduced the Company's
operating expenses and cost requirements in 1998 from 1997 levels.  However, the
Company expects that its research and  development  expenses will continue to be
significant  in the fourth quarter of 1998 and in future years as it pursues its
core drug development programs and expects to continue to incur operating losses
and have significant  capital  requirements  that it will not be able to satisfy
with internally generated funds. The Company continues to explore  opportunities
to reduce  operating  expenses in an effort to conserve its cash resources.  The
number of employees has continued to decline through  attrition;  as of November
10, 1998, the Company had 49 full-time employees.

RESULTS OF OPERATIONS

The Company had total  revenues of  $1,041,000  and $668,000 in the three months
ended September 30, 1998 and 1997,  respectively,  and $3,410,000 and $3,143,000
in the nine months ended  September  30, 1998 and 1997,  respectively.  Revenues
from research and development  collaborations were $150,000 and $200,000 for the
three months ended September 30, 1998 and 1997,  respectively,  and $950,000 and
$980,000 for the nine months ended September 30, 1998 and 1997, respectively.

Product and service  revenue from the HSP Division was $847,000 and $155,000 for
the three months ended September 30, 1998 and 1997, respectively, and $2,353,000
and  $1,231,000  for  the  nine  months  ended  September  30,  1998  and  1997,
respectively. Included in the three months ended September 30, 1998 was $250,000
of  revenue  received  under  its  License   Agreement  with  MethylGene,   Inc.
("MethylGene")  for  certain  services  provided.  The  increase  in product and
service  revenue in 1998 was a result of an expansion  in the customer  base and
increasing  sales to existing  customers  and revenue  earned  under the License
Agreement with MethylGene.

Interest  income was $44,000 and $294,000  for the three months ended  September
30, 1998 and 1997,  respectively,  and $106,000 and $898,000 for the nine months
ended September 30, 1998 and 1997, respectively. The decrease in interest income
is attributable  to the decrease in cash and investments  held by the Company in
1998 as compared to 1997.



                                        1

<PAGE>

The Company had research and development  expenses of $5,201,000 and $11,339,000
for the three  months  ended  September  30,  1998 and 1997,  respectively,  and
$17,181,000  and  $37,785,000  for the nine months ended  September 30, 1998 and
1997,  respectively.  The decrease in research and development  expenses in 1998
reflects the restructuring  program that was commenced during the second half of
1997 and completed in the third quarter of 1998. The restructuring  included the
discontinuation of operations at the Company's facilities in Europe, termination
of the  clinical  development  of GEM 91 and  the  reduction  or  suspension  of
selected programs unrelated to the Company's core advanced  chemistry  antisense
drug development program, including the termination of its ribozyme program. The
restructuring resulted in significant  reductions in employee-related  expenses,
clinical  and outside  testing,  consulting,  materials  and lab  expenses.  The
Company's  facility costs in 1998 were also reduced by the income  received from
subleasing  its  underutilized  facilities.  The Company has now  relocated  its
headquarters  to its  manufacturing  facility,  which  is  located  in  Milford,
Massachusetts.

The Company had general and administrative expenses of $1,504,000 and $3,057,000
for the three  months  ended  September  30,  1998 and 1997,  respectively,  and
$5,218,000 and $9,012,000 for the nine months ended September 30, 1998 and 1997,
respectively.  The  decrease  in general  and  administrative  expenses  in 1998
resulted primarily from the Company's restructuring program initiated during the
second half of 1997 and its effect on employee-related expenses,  consulting and
net facilities costs.

The Company had interest expense of $296,000 and $1,606,000 for the three months
ended September 30, 1998 and 1997,  respectively,  and $2,880,000 and $3,223,000
for the nine  months  ended  September  30,  1998 and  1997,  respectively.  The
decrease in interest expense in 1998 is mainly attributable to the conversion of
approximately  $48.7 million of the 9% Convertible  Subordinated  Notes (the "9%
Notes"), issued in the second quarter of 1997, to Series A Convertible Preferred
Stock on May 5, 1998.

As a result of the above factors, the Company incurred losses from operations of
$5,961,000  and  $18,434,000  for the three months ended  September 30, 1998 and
1997,  respectively,  and  $21,869,000 and $49,977,000 for the nine months ended
September 30, 1998 and 1997, respectively.

The Company had  extraordinary  income of  $8,877,000  for the nine months ended
September  30, 1998  resulting  from the  conversion of the 9% Notes to Series A
Convertible  Preferred  Stock  in the  second  quarter  of 1998.  See  "Item 1 -
Financial Statements - Notes to Consolidated Condensed Financial Statements" for
a  discussion  of the  Company's  extraordinary  income.  As a  result  of  this
transaction, the Company reduced its net loss to $12,993,000 for the nine months
ended September 30, 1998.

LIQUIDITY AND CAPITAL RESOURCES

During the nine months ended  September 30, 1998, the Company's net cash used in
operating  activities  amounted to  $17,444,000.  The Company's  operating  cash
requirements  were funded primarily through the utilization of existing cash and
proceeds raised in private equity offerings conducted in the first half of 1998,
the collection of its accounts  receivable  from sales and services  provided by
the Company,  collaborative  payments  received,  the rental  payments  from its
underutilized  facilities,  and the sale of equipment. The Company believes that
its  existing  and  expected  capital  resources  will be  adequate  to fund the
Company's cash requirements into 1999.

The Company's  existing capital resources include the following amounts received
in the fourth quarter of 1998.  First,  $6,163,000  received in connection  with
relocation of the Company's corporate



                                        2

<PAGE>

headquarters to Milford,  Massachusetts,  and the sale of the Company's interest
in the Charles River  Building  Limited  Partnership,  which owned the Company's
former  headquarters  facility;  this amount  includes a portion of the security
deposit relating to the Company's lease to its former headquarters  facility and
the release of $660,000 in  restricted  cash.  Second,  $254,000 was received in
connection with the sale in October 1998 of certain equipment and furniture.

The  Company's  expected  capital  resources  include  committed   collaborative
research and development payments from Searle, additional amounts expected to be
advanced  under  the  Credit  Facility  (as  described   below),   research  and
development  funding  expected from  MethylGene,  Inc. and the profit margins on
anticipated sales by the HSP Division.

In  June  1998,  the  Company   relocated  its   headquarters   from  Cambridge,
Massachusetts  to its  manufacturing  facility  in Milford,  Massachusetts.  The
Cambridge facility was re-leased in September 1998 to a third party,  subject to
a sublease of a portion of the facility.  As a result,  the Company was relieved
of its substantial  lease obligations for the Cambridge  facility,  subject to a
contingent  continuing  liability  for any  defaults  which may arise  under the
sublease.

Forum  Capital  Markets,  LLC  ("Forum")  and  Pecks  Management  Partners  Ltd.
("Pecks"; Forum and Pecks collectively, the "Lender"), affiliates of two members
of the Company's  Board of  Directors,  have agreed to purchase the loan made by
Silicon Valley Bank to the Company  pursuant to the Loan and Security  Agreement
dated December 31, 1996, between the Company and Silicon Valley Bank, as amended
(the  "Loan"),   the  outstanding   principal   amount  of  which  is  currently
approximately $2.8 million.

In connection  with the purchase of the Loan, the Lender will lend an additional
amount to the Company as soon as practicable  so as to increase the  outstanding
principal amount of the Loan to $6,000,000.  In addition,  the terms of the Loan
will be amended as follows:  (i) the  maturity  will be extended to November 30,
2003;  (ii) the interest  rate will be decreased to 8%; (iii)  interest  will be
payable  monthly in arrears,  with the  principal due in full at maturity of the
Loan; (iv) the Loan will be convertible,  at the Lender's option, in whole or in
part,  into shares of common  stock,  par value $.001 per share,  of the Company
("Common Stock") at a rate equal to the mid-point  between the bid and ask price
on the date of closing of the  purchase of the Loan;  (v) the  threshold  of the
Minimum  Liquidity  covenant will be reduced from $4,000,000 to $2,000,000;  and
the Loan may not be prepaid,  in whole or in part, at any time prior to December
1, 2000. The other terms of the Loan will remain unchanged.

In  connection  with the  purchase  of the  Loan,  Forum  will  receive a fee of
$400,000,  which will be  reinvested  by Forum by  purchasing  from the  Company
either (i) shares of Common  Stock or shares of  preferred  stock of the Company
and accompanying warrants on the same terms as they are sold to investors in the
Company's next equity  offering to occur after November 13, 1998 (the "Placement
Price"),  or (ii) if no equity  offering  is  consummated  prior to May 1, 1999,
160,000  shares of Common  Stock at $3.00 per share and  warrants to purchase an
additional 40,000 shares of Common Stock at $3.00 per share. In addition,  Forum
will  receive  warrants  exercisable  until  maturity  of the  Loan to  purchase
$400,000  of shares  of Common  Stock  priced at the  Placement  Price or, if no
equity offering is consummated  prior to May 1, 1999, at $3.00 per share.  These
shares and warrants will be issued as soon as practicable following satisfaction
of Section 4.10 of the  Indenture  dated as of March 26, 1997,  governing the 9%
Notes.




                                        3

<PAGE>

The Company  will be  required to raise  substantial  additional  funds  through
external sources,  including through  collaborative  relationships and public or
private  financings,  to support its  operations  and,  except for  research and
development  funding  from  Searle  (which is  subject to early  termination  in
certain  circumstances),  revenue is expected to be received from MethylGene and
sale of DNA products and reagents manufactured on a custom contract basis by the
HSP Division,  the Company has no current external  sources of capital,  and, as
discussed  above,  expects no product  revenues for at least  several years from
sales of products that it is developing.

No assurance can be given that such  additional  funds will be available to fund
the Company's operations or, if available,  that such funds will be available on
acceptable  terms. If additional funds are raised by issuing equity  securities,
further dilution to then existing  stockholders will result.  Additionally,  the
terms of any such  additional  financing  may  adversely  affect the holdings or
rights of then existing stockholders.

If  adequate  funds are not  available,  the  Company may be required to further
curtail significantly one or more of its core drug development programs,  obtain
funds  through  arrangements  with  collaborative  partners  or others  that may
require the Company to relinquish rights to certain of its technologies, product
candidates or products  which the Company would  otherwise  pursue on its own or
terminate operations.

The Company's future capital requirements will depend on many factors, including
continued  scientific  progress in its research,  drug discovery and development
programs,  the  magnitude  of these  programs,  progress  with  preclinical  and
clinical trials,  sales of DNA products and reagents to third parties by the HSP
Division and the margins on such sales, the time and costs involved in obtaining
regulatory  approvals,  the costs involved in filing,  prosecuting and enforcing
patent claims,  competing technological and market developments,  the ability of
the Company to establish  and  maintain  collaborative  academic and  commercial
research, development and marketing relationships, the ability of the Company to
obtain  third-party  financing  for  leasehold  improvements  and other  capital
expenditures  and the  costs of  manufacturing  scale-up  and  commercialization
activities and arrangements.

YEAR 2000 Compliance

As has been widely publicized, many computer systems and microprocessors are not
programmed to accommodate dates beyond the year 1999. The Company's  exposure to
this year 2000 ("Y2K")  problem  comes not only from its own  internal  computer
systems and  microprocessors,  but also from the systems and  microprocessors of
its key suppliers, including utility companies and payroll services.

The Company  currently  believes  that all of its  internal  systems will be Y2K
compliant  by the end of the third  quarter of 1999.  The  Company is  currently
evaluating all of its internal computer systems and  microprocessors in light of
the Y2K problem. As part of this process, the Company is conducting an inventory
of its  automated  instruments  and  other  computerized  equipment  and will be
contacting  applicable  vendors for information  regarding Y2K  compliance.  The
Company will then upgrade or otherwise modify its internal  computer systems and
microprocessors,  to the extent necessary.  Testing of all its internal computer
systems and microprocessors  should be completed by the end of the first quarter
of 1999.  The  Company  does not expect the cost of bringing  all the  Company's
systems and microprocessors into Y2K compliance will be material.

The  Company's  Y2K  compliance   efforts  are  in  addition  to  other  planned
information technology ("IT") projects.  While these efforts have caused and may
continue to cause delays in other IT projects, the



                                        4

<PAGE>

Company does not expect that any of these delays will have a significant  effect
on the Company's business or that any of the Company's other IT projects will be
canceled or postponed to pay for the Y2K upgrades.

With regard to potential supplier Y2K problems,  the Company has compiled a list
of its critical  suppliers,  and has sent a Y2K questionnaire to each of them in
order to permit the Company to ascertain the Y2K compliance  status of each. The
Company is awaiting  the return of these  questionnaires.  The Company  does not
know of any key supplier Y2K problems  that could have a material  effect on the
Company's  business.  If through a Y2K  questionnaire  or otherwise  the Company
becomes aware of any such problems and is not satisfied  that those problems are
being adequately  addressed,  it will take appropriate steps to find alternative
suppliers.

It has been acknowledged by governmental  authorities that Y2K problems have the
potential  to disrupt  global  economies,  that no  business  is immune from the
potentially  far-reaching  effects of Y2K problems,  and that it is difficult to
predict with certainty  what will happen after December 31, 1999.  Consequently,
it is possible  that Y2K problems  will have a material  effect on the Company's
business  even if the Company takes all  appropriate  measures to ensure that it
and its key suppliers are Y2K compliant.

It is possible that the conclusions  reached by the Company from its analysis to
date will change,  which could cause the Company's Y2K cost estimates and target
completion dates to change.

SAFE HARBOR FOR FORWARD-LOOKING STATEMENTS

This Form 1O-Q filing contains forward-looking  statements within the meaning of
the "safe harbor" provisions of the Private Securities  Litigation Reform Act of
1995. For this purpose,  any statements contained herein that are not statements
of  historical  fact  may  be  deemed  to be  forward-looking  statements.  Such
forward-looking  statements are based on management's  current  expectations and
involve  known and unknown  risks,  uncertainties,  and other  factors which may
cause the actual  results,  performance  or  achievements  of the  Company to be
materially  different  from any future  results,  performance,  or  achievements
expressed or implied by such  forward-looking  statements.  Without limiting the
foregoing,  the words "believes,"  "anticipates," "plans," "expects," "intends,"
"may," and other similar  expressions  are intended to identify  forward-looking
statements.

Factors  which may cause actual  future  results to differ from  forward-looking
statements include,  among others, the matters set forth under the heading "Item
7.  Management's  Discussion and Analysis of Financial  Condition and Results of
Operations - Certain  Factors that May Affect  Future  Results" in the Company's
Annual  Report on Form 10-K for the year  ended  December  31,  1997 (the  "1997
10-K") which information is incorporated herein by reference.



                                        5

<PAGE>

                                 HYBRIDON, INC.

                                     PART II

                                OTHER INFORMATION

                                     -------



Items 1-4      None
- ---------

Item 5  OTHER INFORMATION
- ------

        Stockholder Proposals for 1999 Annual Meeting
        ---------------------------------------------

        As set  forth in the  Company's  Proxy  Statement  for its  1998  Annual
   Meeting of Stockholders,  stockholder  proposals  submitted  pursuant to Rule
   14a-8  under  the  Securities  and  Exchange  Act of 1934,  as  amended  (the
   "Exchange  Act"),  for inclusion in the Company's proxy material for its 1999
   Annual Meeting of Stockholders  (the "1999 Annual  Meeting") must be received
   by the  Secretary of the Company at the  principal  offices of the Company no
   later than January 18, 1999.

        In addition,  the  Company's  by-laws  require that the Company be given
   advance notice of stockholder nominations for election to the Company's Board
   of  Directors  and of other  matters  (other  than  matters  included  in the
   Company's proxy statement in accordance with Rule 14a-8). The required notice
   must be made in writing and  delivered or mailed by first class United States
   mail,  postage  prepaid,  to the  Secretary  of the Company at the  principal
   offices of the  Company,  and received not less than 60 days nor more than 90
   days prior to the 1999 Annual Meeting; provided however, that if less than 70
   days' notice or prior public  disclosure  of the date of the meeting is given
   to stockholders,  such nomination or other proposal shall have been mailed or
   delivered  to the  Secretary  no later than the close of business on the 10th
   day  following the date on which the notice of the meeting was mailed or such
   public  disclosure  made,  whichever occurs first. The 1999 Annual Meeting is
   currently  expected to be held on May 10, 1999.  Assuming that this date does
   not  change,  in order to  comply  with the  time  periods  set  forth in the
   Company's  by-laws,  appropriate  notice would need to be provided no earlier
   than  February 9, 1999 and no later than March 11, 1999.  The advance  notice
   provisions  of  the  Company's  by-laws  supersede  the  notice  requirements
   contained in recent amendments to Rule 14a-4 under the Exchange Act.


Item 6. Exhibits and Reports on Form 8-K
- ------  --------------------------------


   (a)  Exhibits

        27     Financial Data Schedule (EDGAR)




                                        6

<PAGE>

        99.1   Third Amendment to Loan and Security  Agreement between Hybridon,
               Inc. and Silicon Valley Bank.

        99.2   Fourth Amendment to Loan and Security Agreement between Hybridon,
               Inc. and Silicon Valley Bank.

   (b) No  Reports on Form 8-K have been filed  during the third  quarter  ended
September 30, 1998.






                                        7

<PAGE>

                                   SIGNATURES

                                     -------


   Pursuant to the  requirements  of the  Securities  Exchange Act of 1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned thereunto duly authorized.


                                        HYBRIDON, INC.


January 4, 1999                         /s/ E. Andrews Grinstead III
- -----------------                       ----------------------------
Date                                    E. Andrews Grinstead, III
                                        Chairman, President and Chief Executive
                                        Officer (Principal Executive Officer)


January 4, 1999                         /s/ Robert G Andersen
- -----------------                       ---------------------
Date                                    Robert G. Andersen
                                        Treasurer (Principal Accounting and
                                        Financial Officer)




                                        8

<PAGE>

                                 HYBRIDON, INC.

                                  EXHIBIT INDEX

                                     -------


27      Financial Data Schedule (EDGAR)

99.1    Third Amendment to Loan and Security  Agreement between  Hybridon,  Inc.
        and Silicon Valley Bank.

99.2    Fourth Amendment to Loan and Security  Agreement between Hybridon,  Inc.
        and Silicon Valley Bank.




                                        9

<TABLE> <S> <C>


<ARTICLE>                     5
<LEGEND>
</LEGEND>
<CIK>                         0000861838
<NAME>                        HYBRIDON, INC.
       
<S>                             <C>
<PERIOD-TYPE>                   9-MOS
<FISCAL-YEAR-END>                              DEC-31-1998
<PERIOD-START>                                 JAN-01-1998
<PERIOD-END>                                   SEP-30-1998
<CASH>                                             882,825
<SECURITIES>                                             0
<RECEIVABLES>                                      825,668
<ALLOWANCES>                                             0
<INVENTORY>                                              0
<CURRENT-ASSETS>                                 7,606,865
<PP&E>                                          22,925,187
<DEPRECIATION>                                  13,972,187
<TOTAL-ASSETS>                                  18,398,562
<CURRENT-LIABILITIES>                           10,442,268
<BONDS>                                          1,879,017
                               15,255
                                              0
<COMMON>                                             6,248
<OTHER-SE>                                       6,075,774
<TOTAL-LIABILITY-AND-EQUITY>                    18,398,562
<SALES>                                          2,353,435
<TOTAL-REVENUES>                                 3,409,807
<CGS>                                                    0
<TOTAL-COSTS>                                   22,398,791
<OTHER-EXPENSES>                                         0
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<INTEREST-EXPENSE>                               2,880,307
<INCOME-PRETAX>                                (21,869,291)
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<INCOME-CONTINUING>                            (21,869,291)
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<EXTRAORDINARY>                                  8,876,685
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<NET-INCOME>                                   (12,992,606)
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</TABLE>

                                                                    Exhibit 99.1

                 THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT
                                     BETWEEN
                                 HYBRIDON, INC.
                                       AND
                               SILICON VALLEY BANK


        This Third Amendment is made, effective as of the 18th day of September,
1998 to that certain  Loan and  Security  Agreement  between  Hybridon,  Inc., a
Delaware  corporation  with  a  principal  place  of  business  at  155  Fortune
Boulevard, Milford,  Massachusetts (the "Borrower") and Silicon Valley Bank (the
"Bank")  dated as of December 31, 1996, as amended by consent  letter  agreement
(the "Consent  Letter")  dated  January 15, 1998 and by First  Amendment to Loan
Security  Agreement  dated  March 30, 1998 (the  "First  Amendment")  and Second
Amendment  to Loan and  Security  Agreement  dated April 16,  1998 (the  "Second
Amendment").  The Loan and  Security  Agreement  as so  amended  is  hereinafter
referred to as the "Loan Agreement."  Capitalized terms used, but not defined in
this  Third  Amendment  shall  have the  meanings  ascribed  to them in the Loan
Agreement and ancillary  documents,  instruments  and  agreements,  or if not so
defined,  shall have the  meanings  ascribed to them in the  Uniform  Commercial
Code,  or in the case of financial and  accounting  terms,  in  accordance  with
generally accepted accounting principles.

                                    RECITALS

        Pursuant to the Loan Agreement and on the terms and conditions set forth
therein, on December 31, 1996, the Bank made a secured term loan to the Borrower
in the original face amount of $7,500,000 (the "Loan"). The Borrower advised the
Bank of its planned  offering of Units of investment in the Borrower in January,
1998 (the "Original  Offering"),  which was consented to by the Bank pursuant to
the  Consent  Letter  and which was  subsequently  amended by the  Borrower  and
consented to by the Bank in March,  1998 pursuant to the First  Amendment and in
April,  1998 pursuant to the Second  Amendment.  The term  "Offering" as used in
this Third  Amendment  shall  include the amended  Offering or any other  equity
offering or corporate  collaboration not involving indebtedness of the Borrower.
In connection with the Borrower's  continuing  sales of equity  interests and on
the terms and conditions  set forth herein,  the Borrower has requested that the
Bank  temporarily  waive  compliance by the Borrower with the application of the
Minimum Liquidity and Tangible Net Worth covenants.

        The Bank is  willing to consent  to a  temporary  waiver of the  Minimum
Liquidity  and  Tangible  Net  Worth  covenants,  but only  upon the  terms  and
conditions set forth in this Third Amendment.

                                    AGREEMENT

        In  consideration  of  the  foregoing,   and  of  the  undertakings  and
obligations of the Borrower and the Bank set forth herein and for other good and
valuable   consideration,   receipt   and   sufficiency   of  which  are  hereby
acknowledged, the Borrower and Bank agree as follows:

        1.     The Borrower  confirms that the outstanding  balance of principal
               and  interest on the Loan as of  September  18th,  1998 is as set
               forth in Schedule 1 hereto, and that the Borrower has no defense,
               claim or offset which would preclude full payment of such amount.




<PAGE>

        2.     The Borrower  ratifies and confirms:  (i) its  Obligations to the
               Bank under the Loan Agreement, as amended hereby, (ii) all of the
               representations  and warranties made by it in the Loan Agreement,
               except as expressly  disclosed to the Bank,  and (iii) that it is
               in compliance with the covenants and agreements  contained in the
               Loan Agreement except for its failure to maintain compliance with
               the  covenants  waived in the First  Amendment,  its  failure  to
               comply with Section 6.10(c) of the Loan Agreement,  to the extent
               that  such  failure  is   nevertheless  in  compliance  with  the
               Intellectual   Property  Security  Agreement  (the  "IP  Security
               Agreement")  delivered  by the  Borrower in  connection  with the
               Consent  Letter (it being agreed that the  provisions  of Section
               6.10(c) shall be deemed superseded by the analogous provisions of
               the IP Security Agreement),  and except for Borrower's failure to
               comply  with  the  Minimum   Liquidity  and  Tangible  Net  Worth
               covenants as of June 30, 1998 and thereafter.

        3.     On August  7,  1998,  the  Borrower  established  with the Bank a
               certificate   of  deposit  in  the  amount  of  $1,592,386   (the
               "Deposit").   On  the  date  of  this  Amendment,   the  Borrower
               authorizes the Bank to apply the Deposit  against the outstanding
               principal of the  Obligations as a permanent  reduction  therein.
               Such  payment is in  addition  to any other  regularly  scheduled
               payments due under the Loan Agreement.

        4.     The Bank  hereby  waives any  existing  defaults  of the  Minimum
               Liquidity  and  Tangible  Net  Worth  covenants  and also  waives
               compliance  by  the  Borrower  with  the  Minimum  Liquidity  and
               Tangible  Net  Worth  covenants   through   September  29,  1998;
               provided,  however that if the Borrower earlier receives the cash
               payment due to it for its sale of its  partnership  interest (the
               "CRLP  Interest") in Charles River Building  Limited  Partnership
               (such  date of  receipt,  the "CRLP Put  Date"),  testing of such
               covenants  shall begin on the  following  business  day after the
               CRLP Put Date rather than on September 30, 1998.

        5.     Section 6.8 of the Loan  Agreement,  as  previously  amended,  is
               hereby amended in its entirety to read as follows:

               "Borrower shall  maintain,  as of the last day of each quarter of
               Borrower's fiscal year, a Tangible Net Worth of not less than Six
               Million Dollars ($6,000,000.00)."

        6.     Section 6.9 of the Loan  Agreement,  as  previously  amended,  is
               hereby amended in its entirety to read as follows:

               "Borrower  shall  maintain  Minimum   Liquidity  (as  hereinafter
               defined) of at least $4,000,000 as of the fifteenth (15th) and as
               of the last day of the month (or the next  business day if either
               is not a business day). If the Borrower fails to maintain Minimum
               Liquidity at any test date, the Borrower shall  immediately repay
               the then outstanding  Obligations in full. "Minimum Liquidity" is
               defined as consolidated cash on hand (other than cash in which an
               entity  other  than  the  Bank  or its  assignee  has a  security
               interest, and other than the CRLP Withhold), cash equivalents and
               marketable securities,  plus 50% of the Borrower's Trade Accounts
               Receivable. "Trade Accounts Receivable" means accounts receivable
               arising from the sale of goods and services and the  licensing of
               technology in the ordinary course of the Borrower's business, but
               excluding the



                                        2

<PAGE>

               extraordinary  sale of  assets or other  transactions  not in the
               ordinary course of the Borrower's business."

        7.     Within  two (2)  business  days  after  the  CRLP Put  Date,  the
               Borrower  will pay to the Bank in good and  collected  funds,  in
               addition to any regularly  scheduled payments on the Obligations,
               the  sum  of  $750,000  as  an  additional  payment  against  the
               principal of the  Obligations.  Until  payment of such sum to the
               Bank, all proceeds of the CRLP interest received shall be held in
               trust by the  Borrower  for the Bank.  The  Borrower and the Bank
               agree that this requirement  supersedes any requirement contained
               in the Loan Agreement,  as previously amended,  relating to funds
               received by the Borrower  from CRLP or its  partners,  including,
               without limitation, any requirement as to the use of the proceeds
               of such funds.

        8.     Conditioned  upon  satisfaction of the  requirements set forth in
               this paragraph, the Bank consents to the exclusive license by the
               Borrower to OriGenix  Therapeutics,  Inc.,  a Quebec  corporation
               ("OriGenix"),  of the specific patents and applications listed in
               Schedule 8 hereto (the "Patents"), which license shall be limited
               to use of the Patents for the development of treatments for Human
               Papilloma  Virus  ("HPV"),  Hepatitis  B Virus  ("HBV") and up to
               three (3)  additional  viral  indications to be agreed upon among
               OriGenix and the Borrower,  subject to the prior written  consent
               of  the   Bank   which   will   not  be   unreasonably   withheld
               (collectively,  the "Indications").  The Borrower will retain the
               rights to the Patents for other indication and molecular targets.
               The Bank agrees to deliver to the Borrower documents necessary to
               (i) release its security interest in the patents and applications
               listed in  Schedule 8 which are  designated  with the 189 and 190
               suffixes,   and  (ii)  subordinate,   pursuant  to  an  agreement
               acceptable to the Borrower and OriGenix, its security interest to
               the exclusive  licenses to be granted to OriGenix with respect to
               all of the other patents and  applications  listed in Schedule 8.
               The  consents,  release  and  subordinations  referenced  in this
               paragraph are conditioned  upon (a) the Borrower  retaining a 40%
               equity  ownership in OriGenix,  (b) the Borrower  granting to the
               Bank  a  perfected,  first  priority  security  interest  in  the
               Borrower's  entire ownership  interest in OriGenix  pursuant to a
               Pledge  Agreement  in the form of Exhibit 8, (c)  OriGenix  being
               capitalized  with  a  minimum  cash  equity   investment  of  CDN
               $4,000,000  from investors  other than the Borrower,  and (d) the
               Borrower warranting and representing that no investor in OriGenix
               owns more than five (5%)  percent of the stock of the Borrower on
               a fully converted basis. The Borrower shall,  prior to the Bank's
               delivery of the releases  and  subordinations  referenced  above,
               make a best  efforts  attempt to provide the Bank in writing with
               the names and  addresses  of the  investors in the new entity and
               their  respective  ownership  interests,  a complete  copy of any
               prospectus  or  offering  memorandum  provided  to  investors,  a
               complete  copy of the  business  plan for the new entity and such
               other information as the Bank may reasonably  require,  including
               evidence of the Borrower's 40% interest in OriGenix.

        9.     The   Borrower   further   acknowledges   that   all   reasonable
               out-of-pocket  costs and expenses of the Bank in connection  with
               negotiation,  documentation  and  administration  of  this  Third
               Amendment,  including  reasonable  fees of  attorneys  engaged to
               represent the Bank, shall be borne by the Borrower.




                                        3

<PAGE>

        10.    The Borrower  acknowledges  and confirms  that to the extent that
               the  Borrower  may have any claims,  offsets,  counterclaims,  or
               defenses,  asserted or unasserted,  the Borrower, for itself, and
               on  behalf of its  successors,  assigns,  parents,  subsidiaries,
               agents, affiliates, predecessors, employees, officers, directors,
               executors and heirs, as applicable  (collectively,  the "Borrower
               Affiliates")  releases  and  forever  discharges  the  Bank,  its
               subsidiaries, affiliates, employees, officers, directors, agents,
               successors  and assigns,  both present and former  (collectively,
               the "Bank  Affiliates") of and from any and all manner of claims,
               offsets,  counterclaims,  defenses, action and actions, cause and
               causes  of  action,   suits,   debts,   controversies,   damages,
               judgments,   executions,  and  demands  whatsoever,  asserted  or
               unasserted,  in law or in equity,  which  against the Bank and/or
               the Bank Affiliates,  they or the Borrower Affiliates ever had to
               and including  the date hereof,  upon or by reason of any matter,
               cause,  causes or thing  whatsoever,  in connection with the Loan
               and/or  any of the  transactions  and  matters  related  thereto,
               except  for  the  obligations  of the  Bank  in  such  documents,
               instruments and agreements to be performed after the date of this
               Third Amendment.  The Borrower shall  indemnify,  defend and hold
               the Bank  harmless  of and from any claim  brought or  threatened
               against the Bank by the  Borrower or any other person (as well as
               from  attorneys'  fees and expenses in  connection  therewith) on
               account of the Loan Agreement,  the Note, the Consent Letter, the
               Intellectual  Property  Security  Agreement,   Pledge  Agreement,
               Intercreditor   Agreement,   the  First  Amendment,   the  Second
               Amendment,   this  Third   Amendment  and  any  other   document,
               instrument or agreement given in connection with the Loan and any
               of the  transactions  and matters  related thereto (each of which
               may be defended, compromised, settled or pursued by the Bank with
               counsel  of the  Bank's  election  reasonably  acceptable  to the
               Borrower, but at the expense of the Borrower), except in the case
               of the Bank's failure to comply with its obligations hereunder or
               thereunder, its gross negligence or willful misconduct.

        11.    The Borrower  acknowledges  and agrees that the Bank's  agreement
               herein to temporarily waive compliance with the Minimum Liquidity
               and  Tangible  Net Worth  covenants  shall not create a course of
               dealing or conduct  and that the Bank has not agreed to waive any
               other  covenant  or  agreement  with  the  Borrower  or to  waive
               compliance  with the Minimum  Liquidity  and  Tangible  Net Worth
               covenants  other than for the  limited  time  period set forth in
               this Third Amendment.

        12.    To the extent  possible,  this Third Amendment shall be construed
               to be  consistent  with the  provisions  of the  Loan  Agreement;
               however,  to  the  extent  that  the  provisions  of  this  Third
               Amendment expressly conflict with or contradict the provisions of
               the Loan Agreement,  the provisions of this Third Amendment shall
               be deemed to control.

        13.    This Third Amendment  represents the entire agreement between the
               parties with respect to the modifications  contained herein,  and
               shall  be   construed  in   accordance   with  the  laws  of  the
               Commonwealth  of  Massachusetts  as an agreement  under seal. The
               Borrower  has  voluntarily  entered  into  this  Third  Amendment
               without  coercion  or  duress of any kind and has been or has had
               the  opportunity  to have been  represented  by legal  counsel of
               their choosing.




                                        4

<PAGE>

        WITNESS OUR hands and seals on this 18th day of September, 1998.


HYBRIDON, INC.                                     SILICON VALLEY BANK

By:  /s/Robert G. Andersen                         By:  /s/ Sean Lynden
     ---------------------                              ---------------




                                        5

<PAGE>

                                  SCHEDULE 1 TO
                 THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT
                                     BETWEEN
                               SILICON VALLEY BANK
                               AND HYBRIDON, INC.


Principal Balance as of September 15, 1998         $4,487,175.22
Interest outstanding at September 15, 1998         23,768.61






                                        6


                                                                    Exhibit 99.2

                 FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT
                                     BETWEEN
                                 HYBRIDON, INC.
                                       AND
                               SILICON VALLEY BANK


       This Fourth Amendment is made, effective as of the 29th day of September,
1998,  to that certain Loan and Security  Agreement  between  Hybridon,  Inc., a
Delaware  corporation  with  a  principal  place  of  business  at  155  Fortune
Boulevard, Milford,  Massachusetts (the "Borrower") and Silicon Valley Bank (the
"Bank")  dated as of December 31, 1996, as amended by consent  letter  agreement
(the "Consent Letter") dated January 15, 1998 and by First Amendment to Loan and
Security  Agreement  dated  March  30,  1998  (the  "First  Amendment"),  Second
Amendment  to Loan and  Security  Agreement  dated April 16,  1998 (the  "Second
Amendment") and Third  Amendment to Loan and Security  Agreement dated September
18, 1998 (the "Third Amendment").  The Loan and Security Agreement as so amended
is hereinafter referred to as the "Loan Agreement".  Capitalized terms used, but
not defined in this Fourth Amendment shall have the meanings ascribed to them in
the Loan Agreement and ancillary  documents,  instruments and agreements,  or if
not so  defined,  shall  have  the  meanings  ascribed  to them  in the  Uniform
Commercial Code, or in the case of financial and accounting terms, in accordance
with generally accepted accounting principles.

                                    RECITALS

       Pursuant  to the Third  Amendment,  the  Borrower  and the Bank agreed to
temporarily  waive  compliance  by the Borrower  with the Tangible Net Worth and
Minimum  Liquidity   covenants  (as  amended)  through  September  29,  1998  to
accommodate  the sale by the Borrower of the CRLP  Interest.  The closing of the
sale of the CRLP Interest has not occurred and the Borrower has  requested  that
the Bank agree to extend the waiver of  covenant  compliance  until  October 31,
1998.

       The Bank is willing to  consent  to extend  the  temporary  waiver of the
Minimum Liquidity and Tangible Net Worth covenants,  but only upon the terms and
conditions set forth in this Fourth Amendment.

                                    AGREEMENT

        In  consideration  of  the  foregoing,   and  of  the  undertakings  and
obligations of the Borrower and the Bank set forth herein and for other good and
valuable   consideration,   receipt   and   sufficiency   of  which  are  hereby
acknowledged, the Borrower and Bank agree as follows:

       1.  The Borrower  confirms that the outstanding  balance of principal and
           interest  on the  Loan as of  October  15,  1998 is as set  forth  in
           Schedule 1 hereto,  and that the  Borrower  has no defense,  claim or
           offset which would preclude full payment of such amount.

       2.  The Borrower  ratifies and confirms:  (i) its Obligations to the Bank
           under  the  Loan  Agreement,  as  amended  hereby,  (ii)  all  of the
           representations  and  warranties  made by it in the  Loan  Agreement,
           except as expressly  disclosed  to the Bank,  and (iii) that it is in
           compliance with




<PAGE>

           the covenants and agreements  contained in the Loan Agreement  except
           for its failure to maintain  compliance with the covenants  waived in
           the First  Amendment,  its failure to comply with Section  6.10(c) of
           the Loan  Agreement,  to the extent that such failure is nevertheless
           in compliance with the Intellectual  Property Security Agreement (the
           "IP Security Agreement") delivered by the Borrower in connection with
           the Consent  Letter (it being agreed that the  provisions  of Section
           6.10(c) shall be deemed superseded by the analogous provisions of the
           IP Security  Agreement),  and except for Borrower's failure to comply
           with the Minimum  Liquidity  and Tangible  Net Worth  covenants as of
           June 30, 1998 and thereafter.

       3.  The Bank hereby waives any existing defaults in the Minimum Liquidity
           and Tangible Net Worth  covenants  and also waives  compliance by the
           Borrower with the Minimum  Liquidity and Tangible Net Worth covenants
           through October 31, 1998; provided however, that if the CRLP Put Date
           is earlier  than October 31, 1998,  testing of such  covenants  shall
           begin on the  following  business  day after the CRLP Put Date rather
           than on October 31, 1998. Within two (2) business days after the CRLP
           Put Date,  the  Borrower  will pay to the Bank in good and  collected
           funds,  in  addition  to  any  regularly  scheduled  payments  on the
           Obligations, the sum of $750,000 as an additional payment against the
           principal of the Obligations.

       4.  In  consideration  of the  Bank's  agreement  to extend its waiver of
           compliance  with the  Tangible  Net  Worth  and  Liquidity  covenants
           through  October  31,  1998,  the  Borrower  shall  pay to the Bank a
           forbearance  fee in the amount of $25,000  in  addition  to any other
           amounts due with respect to the Obligations.  If the CRLP Put Date is
           after October 15, 1998, the  forbearance fee shall increase by $1,000
           per day  commencing  October 16,  1998,  but in no event more than an
           additional $16,000. The $25,000 installment of the forbearance fee is
           due and payable on the date of this Fourth Amendment, and any and all
           incremental  increases thereto shall be due and payable no later than
           October 31, 1998.

       5.  The Borrower further  acknowledges that all reasonable  out-of-pocket
           costs  and  expenses  of he  Bank  in  connection  with  negotiation,
           documentation and administration of this Fourth Amendment,  including
           reasonable fees of attorneys  engaged to represent the Bank, shall be
           borne by the Borrower.

       6.  The Borrower  acknowledges  and confirms  that to the extent that the
           Borrower may have any claims,  offsets,  counterclaims,  or defenses,
           asserted or unasserted,  the Borrower,  for itself,  and on behalf of
           its successors,  assigns, parents, subsidiaries,  agents, affiliates,
           predecessors, employees, officers, directors, executors and heirs, as
           applicable  (collectively,  the "Borrower  Affiliates")  releases and
           forever discharges the Bank, its subsidiaries, affiliates, employees,
           officers, directors, agents, successors and assigns, both present and
           former (collectively,  the "Bank Affiliates") of and from any and all
           manner  of  claims,  offsets,  counterclaims,  defenses,  action  and
           actions,  cause and causes of action,  suits,  debts,  controversies,
           damages, judgments,  executions, and demands whatsoever,  asserted or
           unasserted,  in law or in equity,  which  against the Bank and/or the
           Bank  Affiliates,  they or the  Borrower  Affiliates  ever had to and
           including  the date hereof,  upon or by reason of any matter,  cause,
           causes or thing whatsoever, in connection with the Loan and/or any of
           the  transactions  and  matters  related  thereto,   except  for  the
           obligations of the Bank in such documents, instruments and agreements
           to be performed after the date of this Fourth Amendment. The Borrower
           shall  indemnify,  defend and hold the Bank  harmless of and from any
           claim brought or threatened against the Bank by



                                        2

<PAGE>

           the Borrower or any other person (as well as from attorneys' fees and
           expenses in connection  therewith) on account of the Loan  Agreement,
           the Note, the Consent  Letter,  the  Intellectual  Property  Security
           Agreement,  Pledge  Agreement,  Intercreditor  Agreement,  the  First
           Amendment,  the Second  Amendment,  the Third Amendment,  this Fourth
           Amendment and any other  document,  instrument or agreement  given in
           connection  with  the Loan and any of the  transactions  and  matters
           related thereto (each of which may be defended, compromised,  settled
           or pursued by the Bank with counsel of the Bank's election reasonably
           acceptable  to the  Borrower,  but at the  expense of the  Borrower),
           except  in  the  case  of the  Bank's  failure  to  comply  with  its
           obligations hereunder or thereunder,  its gross negligence or willful
           misconduct.

       7.  The Borrower acknowledges and agrees that the Bank's agreement herein
           to  temporarily  waive  compliance  with the  Minimum  Liquidity  and
           Tangible Net Worth  covenants shall not create a course of dealing or
           conduct and that the Bank has not agreed to waive any other  covenant
           or  agreement  with  the  Borrower  or to waive  compliance  with the
           Minimum Liquidity and Tangible Net Worth covenants other than for the
           limited time period set forth in this Fourth Amendment.

       8.  To the extent  possible,  this Fourth Amendment shall be construed to
           be consistent with the provisions of the Loan Agreement;  however, to
           the extent that the  provisions  of this Fourth  Amendment  expressly
           conflict with or contradict the provisions of the Loan Agreement, the
           provisions of this Fourth Amendment shall be deemed to control.

       9.  This Fourth  Amendment  represents the entire  agreement  between the
           parties with respect to the modifications contained herein, and shall
           be  construed  in  accordance  with the laws of the  Commonwealth  of
           Massachusetts   as  an  agreement   under  seal.   The  Borrower  has
           voluntarily  entered into this Fourth  Amendment  without coercion or
           duress  of any kind and has been or has had the  opportunity  to have
           been represented by legal counsel of its choosing.


        WITNESS OUR hands and seals on this 30th day of October, 1998, effective
as of September 29, 1998.



WITNESS:                                    SILICON VALLEY BANK

/s/ C. Wade                                 By:  /s/ Sean Lynden
- -----------                                      ------------------------------

HYBRIDON, INC.

/s/ Cheryl M. Northrup                      By: /s/ E. Andrews Grinstead
- ---------------------                           -------------------------------




                                        3

<PAGE>

                                  SCHEDULE 1 TO
                 FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT
                                     BETWEEN
                               SILICON VALLEY BANK
                               AND HYBRIDON, INC.

Principal Balance as of October 15, 1998           $2,832,289.22
Interest outstanding at October 15, 1998           14,613.83





                                        4



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