HYBRIDON INC
10-Q/A, 1999-04-15
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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     As filed with the Securities and Exchange Commission on April 15, 1999
     ----------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   FORM 10-Q/A
                                (AMENDMENT NO. 2)

                        QUARTERLY REPORT UNDER SECTION 13
                 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

                                     -------


For the Quarter Ended:  June 30, 1998         Commission File Number 0-27352

                                 Hybridon, Inc.
                                 --------------
             (Exact name of registrant as specified in its charter)


           Delaware                           04-3072298               
           --------                           ----------               
(State or other jurisdiction of        (I.R.S. Employer Identification Number)
organization or incorporation)

                                155 Fortune Blvd.
                                Milford, MA 01757
                                -----------------
          (Address of principal executive offices, including zip code)


                                 (508) 482-7500
                                 --------------
              (Registrant's telephone number, including area code)


Indicate by check mark  whether the  registrant  (1) has filed all reports to be
filed by Section 13 or 15(d) of the  Securities  Exchange Act of 1934 during the
preceding 12 months (or for such shorter period that the registrant was required
to file such reports),  and (2) has been subject to such filing requirements for
the past 90 days.

                                    YES X   NO
                                       ---     ---

Indicate the number of shares  outstanding  of each of the  issuer's  classes of
common stock, as of the latest practicable date.

Common Stock, par value $.001 per share                  15,306,825
- ---------------------------------------                ---------------
                 Class                        Outstanding as of April 13, 1999





<PAGE>

                                 HYBRIDON, INC.

                                    Form 10-Q

                                      INDEX


Part I - Financial Information
- ------------------------------

Item 1 - Financial Statements

        Consolidated  Condensed  Balance Sheets as of June 30, 1998 and December
        31, 1997. (As Restated)

        Consolidated  Condensed  Statement  of  Operations  for the Three Months
        ended and Six Months  ended June 30, 1998 and 1997 and  Cumulative  from
        May 25, 1989 (Inception) to June 30, 1998. (As Restated)

        Consolidated Condensed Statements of Cash Flows for the Six Months ended
        June 30, 1998 and 1997, and Cumulative from May 25, 1989 (Inception)
        to June 30, 1998. (As Restated)

        Notes to Consolidated Condensed Financial Statements.


Item 2 - Management's Discussion and Analysis of
           Financial Condition and Results of Operations


Part II - Other Information
- ---------------------------

Item 2 - Changes in Securities and Use of Proceeds

Item 4 - Submission of Matters to a Vote of Security Holders

Item 6 - Exhibits and Reports on Form 8-K

Signatures





<PAGE>


                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)
                      CONSOLIDATED CONDENSED BALANCE SHEETS
                                   (UNAUDITED)

<TABLE>
<CAPTION>


ASSETS
                                                                                 June 30,       December 31,
                                                                                   1998             1997
                                                                              (As Restated)
<S>                                                                              <C>                <C>
CURRENT ASSETS:
         Cash and cash equivalents                                           $     5,518,682   $     2,202,202
         Restricted cash (Note 9)                                                  1,592,368                 -
         Accounts receivable                                                         264,122           529,702
         Accounts receivable related to real estate limited partnership            5,450,000                 -
         Prepaid expenses and other current assets                                   383,926         1,005,825
                                                                             ---------------   ---------------

                  Total current assets                                            13,209,098         3,737,729
                                                                             ---------------   ---------------

PROPERTY AND EQUIPMENT, AT COST:
         Leasehold improvements                                                   11,699,244        16,027,734
         Laboratory equipment                                                      9,041,452         6,770,402
         Equipment under capital leases                                            1,601,535         4,879,190
         Office equipment                                                          1,839,824         1,947,818
         Furniture and fixtures                                                    1,474,862           645,264
         Construction-in-progress                                                     45,409            45,409
                                                                             ---------------   ---------------
                                                                                  25,702,326        30,315,817

         Less -- Accumulated depreciation and amortization                        13,199,366        11,085,013
                                                                             ---------------   ---------------
                                                                                  12,502,960        19,230,804
OTHER ASSETS:
         Restricted cash                                                             659,618         3,050,982
         Note receivable from officer                                                252,950           247,250
         Deferred financing costs and other assets                                   982,289         3,354,767
         Investment in real estate partnership                                             -         5,450,000
                                                                             ---------------   ---------------

                                                                                   1,894,857        12,102,999

                                                                             $    27,606,915   $    35,071,532
                                                                             ===============   ===============
</TABLE>



                 LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)
<TABLE>
<CAPTION>


<S>                                                                          <C>              <C>
CURRENT LIABILITIES:
         Current portion of long-term debt and capital lease obligations     $     4,754,478   $     7,868,474
         Accounts payable                                                          4,194,048         8,051,817
         Accrued expenses                                                          5,352,350        11,917,298
                                                                             ---------------   ---------------
                  Total current liabilities                                       14,300,876        27,837,589
                                                                             ---------------   ---------------

LONG-TERM DEBT AND CAPITAL LEASE OBLIGATIONS, NET OF CURRENT PORTION                 596,431         3,282,123
                                                                             ---------------   ---------------
9% CONVERTIBLE SUBORDINATED NOTES PAYABLE                                          1,306,000        50,000,000
                                                                             ---------------   ---------------

STOCKHOLDERS' EQUITY(DEFICIT):
         Preferred stock, $.01 par value-
                  Authorized -- 5,000,000 shares
                  Series A convertible preferred stock-
                  Designated -- 1,500,000 shares                                           -                 -
                  Issued and outstanding -- 624,789 shares at June 30, 1998            6,248                 -
         Common stock, $.001 par valueB
                  Authorized -- 100,000,000 shares
                  Issued and outstanding -- 15,254,825 and 5,059,650 shares           15,255             5,060
                           at June 30, 1998, and December 31, 1997,
                           respectively
         Additional paid-in capital                                              239,274,774       173,695,698
         Deficit accumulated during the development stage                      (226,907,528)     (218,655,101)
         Deferred compensation                                                     (985,141)       (1,093,837)
                                                                             ---------------   ---------------

                  Total stockholders' equity(deficit)                             11,403,608      (46,048,180)
                                                                             ---------------   ---------------

                                                                             $    27,606,915   $    35,071,532
                                                                             ===============   ===============
</TABLE>

          The  accompanying  notes are an  integral  part of these  consolidated
condensed financial statements.


<PAGE>


                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)

                 CONSOLIDATED CONDENSED STATEMENTS OF OPERATIONS
                                   (UNAUDITED)
<TABLE>
<CAPTION>


                                           Three Months Ended              Six Months Ended           Cumulative from
                                                June 30,                       June 30,                May 25, 1989
                                                                                                      (Inception) to
                                                                                                         June 30,
                                          1998           1997            1998            1997              1998
                                     (As Restated)                   (As Restated)                     (As Restated)
<S>                                 <C>             <C>            <C>             <C>             <C>   
REVENUES:
         Research and development    $      649,915 $       186,250 $       799,915 $       780,150 $         5,799,263
         Product revenue                    681,620         727,704       1,506,689       1,075,858           4,963,641
         Interest income                     44,602         486,502          62,447         603,914           3,283,186
         Royalty and other income                 -          14,971               -          14,971             110,321
                                     -------------- --------------- --------------- --------------- -------------------

                                          1,376,137       1,415,427       2,369,051       2,474,893          14,156,411
                                     -------------- --------------- --------------- --------------- -------------------

OPERATING EXPENSES:
         Research and development         5,577,144      14,969,366      11,979,681      26,445,805         177,439,496
         General and administrative       2,648,907       2,524,046       4,314,019       5,954,499          52,130,635
         Restructuring charge                     -               -               -               -          11,020,000
         Interest                           976,526       1,447,348       2,583,963       1,617,555           8,729,993
                                     -------------- --------------- --------------- --------------- -------------------

                                          9,202,577      18,940,760      18,877,663      34,017,859         249,320,124
                                     -------------- --------------- --------------- --------------- -------------------

         Loss from operations           (7,826,440)    (17,525,333)    (16,508,612)    (31,542,966)       (235,163,713)

EXTRAORDINARY ITEM:
         Gain on exchange of 9%           
         convertible subordinated
         notes payable                    8,876,685               -       8,876,685               -           8,876,685
                                     -------------- --------------- --------------- --------------- -------------------

NET INCOME (LOSS)                         1,050,245    (17,525,333)     (7,631,927)    (31,542,966)       (226,287,028)

ACCRETION OF PREFERRED STOCK
  DIVIDENDS                               (620,500)               -       (620,500)               -           (620,500)
                                     -------------- ---------------- ---------------- -------------- ------------------
                                                    -                               -
         Net income (loss)
         applicable to common        
         stockholders                $      429,745 $  (17,525,333) $   (8,252,427)  $ (31,542,966)     $ (226,907,528)
                                       ============ =============== ===============  ==============     ===============

BASIC AND DILUTED NET INCOME (LOSS)
PER COMMON SHARE (Note 3):

         Loss per share before
         extraordinary item          $       (0.69) $        (3.47) $      (2.01)   $       (6.26)

     Extraordinary item                         .78               -          1.08                -
                                     -------------- --------------- --------------  --------------

     Net income (loss) per share                .09          (3.47)         (0.93)          (6.26)

     Accretion of preferred stock
      dividends                               (0.05)             -         (0.08)                -
                                     --------------- -------------- --------------  --------------

     Net income (loss) per share
      applicable to common 
      stockholder                    $          .04 $        (3.47) $       (1.01)   $       (6.26)
                                     ============== ===============  =============   ==============

SHARES USED IN COMPUTING BASIC AND
DILUTED NET LOSS PER COMMON SHARE
(Note 2)                                 11,333,604       5,048,391       8,196,627       5,042,369
                                     ============== =============== =============== ===============

</TABLE>

          The  accompanying  notes are an  integral  part of these  consolidated
condensed financial statements.


<PAGE>


                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)
                 CONSOLIDATED CONDENSED STATEMENTS OF CASH FLOWS
                                   (UNAUDITED)


<TABLE>
<CAPTION>

                                                                            Six Months Ended            Cumulative from
                                                                                June 30,                  May 25, 1989
                                                                                                         (Inception) to
                                                                                                            June 30,
                                                                          1998             1997               1998
                                                                     (As Restated)                       (As Restated)
<S>                                                                <C>              <C>                 <C>
CASH FLOWS FROM OPERATING ACTIVITIES:
         Net loss                                                   $   (7,631,927)   $  (31,542,966)    $  (226,287,028)
         Adjustments to reconcile net loss to net cash used in
         operating activitiesB
                  Extraordinary gain on exchange of 9%                  (8,876,685)                 -         (8,876,685)
                    convertible subordinated notes payable
                  Depreciation and amortization                           1,785,353         2,241,374          12,971,807
                  Loss on disposal of fixed assets                          228,000                 -             228,000
                  Issuance of common  stock for services rendered                 -           146,875             146,875
                  Compensation on grant of stock options,                   108,696           188,412           8,232,494
                    warrants and restricted stock
                  Amortization of discount on convertible                         -                 -             690,157
                     promissory notes payable
                  Amortization of deferred financing costs                  225,816           250,395             922,285
                  Noncash interest on convertible promissory                      -                 -             260,799
                     notes payable
                  Write-down of assets related to restructuring                   -                 -           1,255,000
                  Changes in operating assets and liabilitiesB
                           Accounts receivable                              265,580          (70,609)           (264,122)
                           Prepaid and other current assets                 122,148         (108,610)           (883,676)
                           Note receivable from officer                     (5,700)           (4,663)           (252,950)
                           Amounts payable to related parties                     -                 -           (200,000)
                           Accounts payable and accrued expenses          (330,465)         (572,356)          18,983,650
                           Deferred revenue                                       -          (86,250)                   -
                                                                    ---------------   ---------------  ------------------

                           Net cash used in operating activities       (14,109,184)      (29,558,398)       (193,073,394)
                                                                    ---------------   ---------------  ------------------

CASH FLOWS FROM INVESTING ACTIVITIES:
         Increase in short-term investments                                       -      (16,267,615)                   -
         Purchases of property and equipment, net                         (285,509)       (5,838,183)        (29,597,974)
         Proceeds from sale of fixed assets                                 400,000                 -             400,000
         Investment in real estate partnership                                    -                 -         (5,450,000)
                                                                    ---------------   ---------------  ------------------

                           Net cash provided by (used in)
                             investing activities                           114,491      (22,105,798)        (34,647,974)
                                                                    ---------------   ---------------  ------------------

CASH FLOWS FROM FINANCING ACTIVITIES:
         Proceeds from issuance of convertible preferred stock            7,999,960                 -         104,584,114
         Proceeds from issuance of common stock related to stock                  -            62,327           1,260,928
                  options and restricted stock grants
         Proceeds from issuance of common stock related to stock                  -             9,075           3,185,816
                  warrants
         Net proceeds from issuance of common stock                       6,876,676                 -          59,232,000
         Repurchase of common stock                                               -                 -               (263)
         Proceeds from notes payable                                              -                 -           9,450,000
         Proceeds from issuance of convertible promissory notes           4,233,833        50,000,000          63,425,577
                  payable
         Proceeds from long-term debt                                             -                 -             662,107
         Payments on long-term debt and capital leases                  (2,489,782)         (895,183)         (5,855,662)
         Proceeds from sale/leaseback                                             -         1,165,236           4,001,018
         Decrease (increase) in restricted cash and other assets            690,486           133,878         (3,448,646)
         (Increase) in deferred financing costs                                   -       (2,849,958)         (3,256,939)
                                                                    ---------------   ---------------  ------------------

                  Net cash provided by financing activities              17,311,173        47,625,375         233,240,050
                                                                    ---------------   ---------------  ------------------

NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS                      3,316,480       (4,038,821)           5,518,682

CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD                            2,202,202        12,633,742                   -
                                                                    ---------------   ---------------  ------------------

CASH AND CASH EQUIVALENTS, END OF PERIOD                            $     5,518,682   $     8,594,921  $        5,518,682
                                                                    ===============   ===============  ==================

SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION:
         Cash paid for interest                                     $     1,261,502   $       492,555  $        4,891,952
                                                                    ===============   ===============  ==================
</TABLE>


          The  accompanying  notes are an  integral  part of these  consolidated
condensed financial statements.


<PAGE>

                        HYBRIDON, INC. AND SUBSIDIARIES
                         (A Development Stage Company)

              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                  (UNAUDITED)

(1)     ORGANIZATION

        Hybridon,  Inc. (the Company) was  incorporated in the State of Delaware
        on May 25, 1989. The Company is engaged in the discovery and development
        of novel genetic medicines based primarily on antisense technology.  The
        Company is in the development  stage.  Since inception,  the Company has
        been engaged primarily in research and development efforts,  development
        of its manufacturing  capabilities and organizational efforts, including
        recruiting of scientific and management  personnel and raising  capital.
        To  date,  the  Company  has  not  received  revenue  from  the  sale of
        biopharmaceutical   products   developed   by  it  based  on   antisense
        technology. In order to commercialize its own products, the Company will
        need to address a number of  technological  challenges  and comply  with
        comprehensive regulatory requirements.  Accordingly,  it is not possible
        to predict  the amount of funds that will be  required  or the length of
        time that will pass before the Company  receives  revenues from sales of
        any of these products. All revenues received by the Company to date have
        been derived from collaboration agreements, interest on investment funds
        and revenues from the custom contract manufacturing of synthetic DNA and
        reagent products by the Company's  Hybridon Specialty Products Division.
        As a result,  although the Company has begun to generate  revenues  from
        its  contract  manufacturing  business,  the Company is dependent on the
        proceeds  from  possible  future  sales  of  equity   securities,   debt
        financings and research and development  collaborations in order to fund
        future operations.

        On May 5, 1998,  the  Company  completed  a private  offering  of equity
        securities  raising total gross proceeds of approximately  $26.7 million
        from the issuance of 9,597,476 shares of common stock, 114,285 shares of
        Series A convertible  preferred stock and warrants to purchase 3,329,486
        shares of common stock at $2.40 per share.  The gross  proceeds  include
        the  conversion  of  approximately  $5.9  million of  accounts  payable,
        capital lease  obligations and other  obligations into common stock. The
        Company incurred  approximately $1.6 million of cash expenses related to
        the  private  offering  and issued  597,699  shares of common  stock and
        warrants to purchase 1,720,825 shares of common stock at $2.40 per share
        to the placement agents. The compensation  received by Pillar, a company
        affiliated  with certain  directors of the Company,  with respect to the
        offshore component of the private offering (Offshore Offering) consisted
        of (i) 9% of  gross  proceeds  of  such  Offshore  Offering  and  (ii) a
        non-accountable  expense allowance equal to 4% of gross proceeds of such
        Offshore  Offering.  Pillar  received  approximately  $1.6  million  and
        warrants  to  purchase  1,111,630  shares of  common  stock at $2.40 per
        share.  In  addition,  Pillar is entitled to receive  300,000  shares of
        common stock in connection  with its efforts in assisting the Company in
        restructuring  its balance sheet.  The Company has recorded  $600,000 of
        general and  administrative  expense in the  accompanying  statements of
        operations,  which  represents  the value of this common stock on May 5,
        1998.

        On February  6, 1998,  the Company  commenced  an exchange  offer to the
        holders of the 9%  Convertible  Subordinated  Notes (the 9% Notes)  (see
        Note 6) to  exchange  the 9% Notes for  Series A  convertible  preferred
        stock and certain warrants of the Company. On May 5, 1998,




<PAGE>

                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)

              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)



        Noteholders holding $48.7 million of principal and $2,361,850 of accrued
        interest tendered such principal and accrued interest to the Company for
        510,505 shares of Series A convertible  preferred  stock and warrants to
        purchase  3,002,958  shares of common  stock with an  exercise  price of
        $4.25 per share.  In accordance  with Statement of Financial  Accounting
        (SFAS)  No.15,  Accounting  by Debtors and  Creditors  for Troubled Debt
        Restructurings,   the  Company   recorded  an   extraordinary   gain  of
        approximately $8.9 million related to the conversion.  The extraordinary
        gain  represents  the  difference  between the carrying  value of the 9%
        Notes plus accrued interest, less $2,249,173 of deferred financing costs
        written  off and the fair  value of the Series A  convertible  preferred
        stock,  as  determined  by  the  per  share  sales  price  of  Series  A
        convertible  preferred  stock  sold in the  private  offering  described
        above, and warrants to purchase common stock issued by the Company.

(2)     UNAUDITED INTERIM FINANCIAL STATEMENTS

        The  unaudited  consolidated  condensed  financial  statements  included
        herein have been prepared by the Company, without audit, pursuant to the
        rules and  regulations  of the  Securities  and Exchange  Commission and
        include,  in the opinion of management,  all adjustments,  consisting of
        normal,  recurring  adjustments,  necessary for a fair  presentation  of
        interim period results.  Certain  information  and footnote  disclosures
        normally  included in financial  statements  prepared in accordance with
        generally accepted accounting  principles have been condensed or omitted
        pursuant to such rules and regulations.  The Company believes,  however,
        that its disclosures are adequate to make the information  presented not
        misleading.  The  results  for the  interim  periods  presented  are not
        necessarily  indicative  of results to be  expected  for the full fiscal
        year.  It is  suggested  that  these  financial  statements  be  read in
        conjunction with the audited consolidated financial statements and notes
        thereto  included in the  Company's  Annual  Report on Form 10-K for the
        year ended  December 31, 1997, as filed with the Securities and Exchange
        Commission.

        In April of 1999,  the  Company  restated  its June 30,  1998  financial
        statements to reflect the accretion on the Series A preferred  stock and
        $600,000 of general and  administrative  expense related to common stock
        issuable to Pillar (see Note 1). Such restatement resulted in a decrease
        in the net loss applicable to common  stockholders of $1,220,500 for the
        three and six months ended June 30, 1998 (see Note 13).

(3)     SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

        Net Income (Loss) per Common Share

        The Company  applies SFAS No. 128,  Earnings per Share,  in  calculating
        earnings  per share.  Basic net income  (loss) per share is  computed by
        dividing  net loss by the  weighted  average  number  of  common  shares
        outstanding during the period. Diluted net loss per share for the




<PAGE>

                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)

              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)



        periods  presented  is the  same as  basic  net  loss  per  share as the
        inclusion  of  the   potential   common  stock   equivalents   would  be
        antidilutive.

(4)     CASH EQUIVALENTS

        The Company  considers all highly liquid  investments with maturities of
        three  months or less when  purchased to be cash  equivalents.  Cash and
        cash  equivalents  and restricted cash at June 30, 1998 and December 31,
        1997 consisted of the following (at amortized cost,  which  approximates
        fair market value):

<TABLE>
<CAPTION>

                                                                  June 30,          December 31, 
                                                                    1998                1997
<S>                                                          <C>                <C>    

          Cash and cash equivalents-
                   Cash and money market funds               $        5,289,964  $        1,702,272
                   Corporate bond                                       228,718             499,930
                                                             ------------------  ------------------

                                                             $        5,518,682  $        2,202,202
                                                             ==================  ==================

          Restricted cash-current
                   Certificates of deposit (Note 9)          $        1,592,368  $                -
                                                             ==================  ==================

          Restricted cash-long term
                   Certificates of deposit                   $                -  $        2,016,364
                   Savings account                                      659,618           1,034,618
                                                             ------------------  ------------------

                                                             $          659,618  $        3,050,982
                                                             ==================  ==================

</TABLE>

(5)     ACCOUNTS RECEIVABLE RELATED TO REAL ESTATE LIMITED PARTNERSHIP

        Under  the  terms  of  the  Cambridge,   Massachusetts   building  lease
        (Cambridge  Lease), the Company accounted for $5,450,000 of its payments
        for a portion of the costs of  construction  of the leased  premises  as
        contributions to the capital of the Cambridge landlord in exchange for a
        limited partnership  interest in the Cambridge landlord (the Partnership
        Interest).  Under the terms of the Partnership Interest, the Company has
        the right at any time  prior to  February  2000 to sell the  Partnership
        Interest  back to the other limited  partners of the landlord.  In April
        1998,  the  Company  exercised  its right to sell  back the  Partnership
        Interest.  The  contribution  to the real  estate  partnership  has been
        classified  as a  current  asset at June 30,  1998,  since  the  Company
        anticipates receiving payment within one year.





<PAGE>

                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)

              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)



(6)     9.0% CONVERTIBLE SUBORDINATED NOTES

        On April 2, 1997,  the Company issued  $50,000,000  of the 9% Notes.  As
        discussed in Note 1, on May 5, 1998 Noteholders holding $48.7 million of
        principal  value of the 9% Notes  tendered  such notes in  exchange  for
        Series A  convertible  preferred  stock and warrants to purchase  common
        stock. In addition, $2,361,850 of accrued interest thereon was converted
        into  shares of Series A  convertible  preferred  stock and  warrants to
        purchase common stock. As of June 30, 1998,  there is $1.3 million of 9%
        Notes  outstanding.  Under the terms of the 9% Notes,  the Company  must
        make semi-annual interest payments on the outstanding  principal balance
        through  the  maturity  date of  April  1,  2004.  If the 9%  Notes  are
        converted  prior to April 1,  2000,  the  Noteholders  are  entitled  to
        receive  accrued  interest  from the date of the  most  recent  interest
        payment through the conversion date. The 9% Notes are convertible at any
        time prior to the maturity date at a conversion  price equal to $35.0625
        per  share,  subject  to  adjustment  under  certain  circumstances,  as
        defined.

        Beginning  April 1,  2000,  the  Company  may redeem the 9% Notes at its
        option for a 4.5%  premium over the original  issuance  price,  provided
        that  from  April 1,  2000 to March  31,  2001,  the 9% Notes may not be
        redeemed  unless the closing price of the common stock equals or exceeds
        150% of the  conversion  price  for a  period  of at  least 20 out of 30
        consecutive  trading days and the 9% Notes redeemed within 60 days after
        such  trading  period.  The premium  decreases by 1.5% each year through
        March 31, 2003. Upon a change of control of the Company, as defined, the
        Company will be required to offer to repurchase  the 9% Notes at 150% of
        the original issuance price.

(7)     NEW ACCOUNTING STANDARDS

        Effective  January 1, 1998, the Company adopted SFAS No. 130,  Reporting
        Comprehensive Income. SFAS No. 130 requires disclosure of all components
        of  comprehensive  income on an annual and interim basis.  Comprehensive
        income is  defined  as the  change in  equity of a  business  enterprise
        during a period from  transactions  and other  events and  circumstances
        from non-owner  sources.  The Company's total  comprehensive  net income
        (loss) for the three and six month  periods ended June 30, 1998 and 1997
        were the same as reported net income (loss) for those periods.

        In July 1997, the FASB issued SFAS No. 131,  Disclosures  About Segments
        of an Enterprise and Related Information.  SFAS No. 131 requires certain
        financial and supplementary information to be disclosed on an annual and
        interim basis for each reportable segment of an enterprise. SFAS No. 131
        is effective for fiscal years beginning after December 15, 1997.  Unless
        impracticable,  companies  would be  required  to restate  prior  period
        information  upon  adoption.  The Company  believes that the adoption of
        SFAS No. 131 will not have a material impact on its financial results or
        financial position.




<PAGE>

                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)

              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)


(8)     RESTRUCTURING

        Beginning in July 1997, the Company  implemented a restructuring plan to
        reduce  expenditures  on a phased  basis over the  balance of 1997 in an
        effort to conserve its cash resources.  As a part of this  restructuring
        plan, the Company recorded an $11,020,000  restructuring  charge in 1997
        to provide for (i) the termination of certain  research  programs,  (ii)
        the abandonment of certain leased  facilities (net of sublease  income),
        (iii) severance  obligations to nearly 100 terminated employees and (iv)
        the  cancellation  of certain  other  contracts.  During June 1998,  the
        Company  vacated  the  Cambridge,  MA facility  and moved its  corporate
        headquarters to Milford, MA.

        The total cash impact of the  restructuring  amounted  to  approximately
        $3,426,000.  The total cash paid as of June 30,  1998 was  approximately
        $2,721,000 and the remaining amount will be paid in 1998.

(9)     NOTE PAYABLE TO A BANK

        In December 1996, the Company  entered into a five year  $7,500,000 note
        payable with a bank. The note contains certain financial  covenants that
        require the Company to maintain  minimum  tangible net worth and minimum
        liquidity and prohibits the payment of dividends. The note is payable in
        59 equal  installments of $62,500  commencing on February 1, 1997 with a
        balloon payment of the then remaining outstanding principal balance, due
        on January 1, 2002.  During 1997,  the Company's  minimum  liquidity had
        fallen below the required amount and the Company deposited $1,758,542 as
        collateral  under  the cash  pledge  agreement.  During  1998,  the bank
        withdrew the full amount of the  restricted  cash and applied it against
        the outstanding balance of the note. The minimum liquidity  requirements
        were  subsequently  amended to provide that if as of the  fifteenth  and
        last day of each  calendar  month  the  Company  does  not have  minimum
        liquidity of at least $8,000,000 or $4,000,000,  as defined, the Company
        will be  required  to  immediately  repay  to the  bank  35%  and  100%,
        respectively,  of the then outstanding balance. Also, in connection with
        the note,  the  Company  issued five year  warrants  to purchase  13,000
        shares of common stock at an exercise  price of $34.49 per share.  These
        warrants  were fully  exercisable  at December 31, 1997.  As of June 30,
        1998,  approximately $4,611,000 was outstanding under the note, which is
        classified  as a current  liability  in the  accompanying  June 30, 1998
        balance  sheet.   Subsequent  to  June  30,  1998,  the  Company  placed
        approximately $1.6 million in escrow at the bank's request. In addition,
        in August 1998 the $1.6 million will be applied  against the outstanding
        amount  of  the  note.  Also,  upon  the  closing  of  the  sale  of the
        Partnership  Interests  (see Note 5) the Company will be required to pay
        down an additional $750,000 on the note.





<PAGE>

                                HYBRIDON, INC. AND SUBSIDIARIES
                                 (A Development Stage Company)

                     NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                         (UNAUDITED)



(10)    METHYLGENE, INC. LICENSING AGREEMENT

        In January  1996,  the  Company and  MethylGene,  Inc.  (MethylGene)  (a
        Canadian  company which is over 30% owned by the Company) entered into a
        licensing  agreement  for the  purpose  of  researching  and  developing
        compounds  for the  treatment  of cancer and other  indications.  In May
        1998,  this  agreement was amended to grant  MethylGene a  non-exclusive
        right to use all and any antisense chemistries discovered by the Company
        or any of its  affiliates  for a period  commencing  on May 5,  1998 and
        ending  on the  earlier  of (i) the  effective  date of  termination  by
        MethylGene  of its contract for  development  services to be provided by
        the Company, (ii) May 5, 1999, unless MethylGene exercises its option to
        continue  contracting for development  services provided by the Company,
        or (iii) May 5, 2000. As additional consideration for this non-exclusive
        right,  MethylGene is required to pay the Company certain  milestone and
        royalty amounts, as defined, and transfer 300,000 shares of MethylGene's
        class B shares to the Company.  The Company has placed no value on these
        shares.

(11)    UNITS ISSUED TO PRIMEDICA CORPORATION

        In connection  with the unit  financing  (see Note 1) the Company issued
        250,000  shares of common stock and 62,500  warrants to purchase  common
        stock to Primedica  Corporation  (Primedica)  for future  services to be
        provided.  The services shall commence upon the Company's  request after
        (i) the  Company's  securities  are  listed on a  nationally  recognized
        exchange,  and (ii) the average  closing price of the  Company's  common
        stock is at least  $2.00  per share for the  twenty-day  trading  period
        preceding the contract  commencement date. In the event that the Company
        does not use  these  services  as a result  of the  failure  to meet the
        contract conditions,  Primedica shall forfeit to the Company all or part
        of the common  stock and  warrants  held by  Primedica.  The Company has
        recorded these shares as issued and  outstanding at June 30, 1998 at par
        value.  The  Company  will  record  the value of these  services  as the
        services are rendered.






<PAGE>

                         HYBRIDON, INC. AND SUBSIDIARIES
                          (A Development Stage Company)

              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                   (UNAUDITED)



(12)    SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION

        The accompanying consolidated financial statements include the following
information:

<TABLE>
<CAPTION>

                                                                                                    Cumulative from
                                                                                                       May 25,1989
                                                                            Six Months Ended         (Inception) to
                                                                                 June 30,               June 30,
                                                                           1998           1997           1998
<S>                                                                        <C>             <C>

   SUPPLEMENTAL DISCLOSURE OF NONCASH FINANCING
   ACTIVITIES:

         Issuance  of  Series  A  convertible  preferred  stock  and
         attached   warrants  in  exchange  for   conversion  of  9%
         convertible subordinated notes payable and accrued interest     $   51,055,850  $  ---     $   51,055,850

         Accretion of Series A convertible preferred stock dividends     $      620,500  $  ---     $      620,500

         Issuance of common stock and attached warrants in exchange
         for conversion of  convertible subordinated notes payable       $    4,800,000   $  ---     $    4,800,000
                                                                        

         Issuance of common stock in exchange for conversion of
         accounts payable and other obligations                          $    5,934,558   $  ---     $    5,934,558


</TABLE>


<PAGE>

                                HYBRIDON, INC. AND SUBSIDIARIES
                                 (A Development Stage Company)

                     NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS
                                         (UNAUDITED)



(13)    RESTATEMENT OF JUNE 30, 1998

        In April of 1999, the Company restated its 1998 financial  statements to
        reflect the  accretion on the Series A convertible  preferred  stock and
        $600,000 of general  and  administrative  expense  related to the common
        stock issuable to Pillar (see Note 1). The following  table presents the
        net income (loss),  net income (loss) applicable to common  stockholders
        and net income (loss) per share as originally reported, and as restated.


<TABLE>
<CAPTION>

                                      Three Months Ended                             Six Months Ended
                                         June 30, 1998                                June 30, 1998

<S>                           <C>                   <C>                     <C>                   <C>

                              As Reported            As Restated            As Reported            As Restated
                              -----------            -----------            -----------            -----------

Net Income (Loss)             $ 1,650,245            $ 1,050,245           $ (7,031,927)          $ (7,631,927)

Net Income (Loss)
applicable to common
stockholders                    1,650,245                429,745             (7,031,927)            (8,252,427)

Net Income (Loss) per              
share                              $ 0.15                 $ 0.04                $ (0.86)               $ (1.01)

</TABLE>


<PAGE>

Item 2. MANAGEMENT'S  DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
        OF OPERATIONS


The Company is engaged in the discovery  and  development  of genetic  medicines
based on antisense technology. The Company commenced operations in February 1990
and since that time has been  engaged  primarily  in  research  and  development
efforts,  development  of  its  manufacturing  capabilities  and  organizational
efforts,  including  recruitment  of scientific and  management  personnel,  and
raising capital.  To date, the Company has not received revenue from the sale of
biopharmaceutical  products  developed by it. In order to commercialize  its own
products, the Company will need to address a number of technological  challenges
and comply with comprehensive  regulatory requirements.  Accordingly,  it is not
possible  to predict  the amount of funds that will be required or the length of
time that will pass before the Company  receives  revenues  from sales of any of
these products.  All revenues  received by the Company to date have been derived
from collaborative agreements,  interest on invested funds and revenues from the
custom  contract  manufacturing  of  synthetic  DNA and reagent  products by the
Hybridon Specialty Products ("HSP") Division.

The Company has incurred  cumulative losses from inception through June 30, 1998
of approximately $226.3 million. The Company implemented a restructuring plan in
the second half of 1997 which will significantly  reduce the Company's operating
expenses and cost  requirements in 1998 from 1997 levels.  However,  the Company
expects  that  its  research  and  development  expenses  will  continue  to  be
significant  in 1998 and future  years as it pursues  its core drug  development
programs and expects to continue to incur operating  losses and have significant
capital  requirements  that it  will  not be able  to  satisfy  with  internally
generated  funds.  The  Company  continues  to explore  opportunities  to reduce
operating  expenses in an effort to conserve its cash  resources.  The number of
employees has continued to decline,  through attrition,  resulting in a total of
50 full time  employees as of August 10, 1998.  In  connection  with the ongoing
restructuring,   the  Company   completed   the   relocation  of  its  corporate
headquarters to Milford, Massachusetts,  the site of the Company's HSP Division.
See "Liquidity and Capital Resources."

This Quarterly Report on Form 10-Q contains forward-looking statements. For this
purpose,  any statements  contained herein that are not statements of historical
fact may be  deemed  to be  forward-looking  statements.  Without  limiting  the
foregoing, the words "believes",  "anticipates",  "plans", "expects", "intends",
"may",  and other similar  expressions are intended to identify  forward-looking
statements.  There  are a number  of  important  factors  that  could  cause the
Company's  actual  results to differ  materially  from those  indicated  by such
forward-looking  statements.  These factors  include the matters set forth under
the heading "Item 7. Management's Discussion and Analysis of Financial Condition
and Results of Operations - Certain  Factors that May Affect Future  Results" in
the Company's  Annual  Report on Form 10-K for the year ended  December 31, 1997
(the "1997 10-K") which information is incorporated herein by reference.

RESTATEMENT OF JUNE 30, 1998 FINANCIAL STATEMENTS

In April of 1999, the Company restated its 1998 financial  statements to reflect
the  accretion on the Series A convertible  preferred  stock and the issuance of
300,000 shares of common stock which Pillar is entitled to receive in connection
with its efforts in assisting  the Company in  restructuring  its balance  sheet
(see Notes 1, 2 and 13).






<PAGE>

RESULTS OF OPERATIONS

The Company had total  revenues of $1,376,000 and $1,415,000 in the three months
ended June 30, 1998 and 1997, respectively, and $2,369,000 and $2,475,000 in the
six months ended June 30, 1998 and 1997,  respectively.  Revenues  from research
and development  collaborations  were $650,000 and $186,000 for the three months
ended June 30, 1998 and 1997,  respectively,  and  $800,000 and $780,000 for the
six months  ended June 30, 1998 and 1997,  respectively.  Revenues for the three
months  ended June 30, 1998  increased  primarily  due to the Company  receiving
certain payments under its License Agreement with MethylGene, Inc., an entity in
which the Company has an over 30% interest. Despite the increase in revenues for
the full six months ended June 30, 1998, primarily as a result of the MethylGene
payments,  revenues  for the full six months  ended June 30,  1998 and 1997 were
approximately  the same due to the  cancellation of the Roche  collaboration  in
1997.

Product  revenue  from HSP was  $682,000 and $728,000 for the three months ended
June 30, 1998 and 1997, respectively.  The decrease was primarily due to the mix
of  products  sold  during the  periods.  Product  revenue  was  $1,507,000  and
$1,076,000  for the six months ended June 30, 1998 and 1997,  respectively.  The
increase was a result of an expansion in the customer base and increasing  sales
to existing customers.

Interest  income was $45,000 and  $487,000  for the three  months ended June 30,
1998 and 1997,  respectively,  and $62,000 and $604,000 for the six months ended
June 30,  1998 and  1997,  respectively.  The  decrease  in  interest  income is
attributable to the decrease in cash and investments held by the Company in 1998
as compared to 1997.

The Company had research and development  expenses of $5,577,000 and $14,969,000
for the three months ended June 30, 1998 and 1997, respectively, and $11,980,000
and $26,446,000  for the six months ended June 30, 1998 and 1997,  respectively.
The decrease in research and development expenses in 1998 reflects the Company's
restructuring  commenced  during  the  second  half of 1997.  The  restructuring
included the  discontinuation  of  operations  at the  Company's  facilities  in
Europe,  termination of the clinical  development of GEM 91 and the reduction or
suspension  of  selected  programs  unrelated  to the  Company's  core  advanced
chemistry antisense drug development  program,  including the termination of its
ribozyme  program.  The  restructuring  resulted in  significant  reductions  in
employee-related expenses, clinical and outside testing,  consulting,  materials
and lab expenses.  The Company's facility costs in 1998 were also reduced by the
income received from subleasing its unutilized facilities.

The Company had general and administrative expenses of $2,649,000 and $2,524,000
for the three months ended June 30, 1998 and 1997, respectively,  and $4,314,000
and  $5,954,000  for the six months ended June 30, 1998 and 1997,  respectively.
The  increase in general and  administrative  expense for the three months ended
June 30, 1998 includes a $600,000 charge for common stock to be issued to Pillar
as discussed in Note 1.  Excluding  the $600,000  charge  discussed  above,  the
decrease in general and administrative  expenses in 1998 resulted primarily from
the Company's restructuring program initiated during the second half of 1997 and
its effect on employee-related expenses, consulting and net facilities costs.

The Company had interest expense of $977,000 and $1,447,000 for the three months
ended June 30, 1998 and 1997,  respectively,  and  $2,584,000 and $1,618,000 for
the six months  ended June 30,  1998 and 1997,  respectively.  The  decrease  in
interest expense for the three months ended June 30, 1998 is




<PAGE>

mainly  attributable to the conversion of  approximately  48.7 million of the 9%
Convertible Subordinated Notes ("the 9% Notes"), issued in the second quarter of
1997, to Series A Convertible  Preferred  Stock on May 5, 1998.  The increase in
interest  expense for the six months ended June 30, 1998 is mainly  attributable
to the first  quarter's  interest  expense of the 9% Notes which were originally
issued in April 1997.

As a result of the above factors, the Company incurred losses from operations of
$7,826,000  and  $17,525,000  for the three months ended June 30, 1998 and 1997,
respectively,  and $16,509,000 and $31,543,000 for the six months ended June 30,
1998 and 1997, respectively.

The Company had extraordinary  income of $8,877,000 for the three and six months
ended June 30, 1998  resulting  from the  conversion of the 9% Notes to Series A
Convertible  Preferred  Stock.  See  "Item 1  Financial  Statements  -- Notes to
Consolidated  Condensed Financial  Statements" for a discussion of the Company's
extraordinary  income. As a result of this  transaction,  the Company recorded a
net income after  extraordinary  income of $1,050,000 for the three months ended
June 30, 1998 and reduced its net loss to  $7,632,000  for the six months  ended
June 30, 1998.


RESTATEMENT OF JUNE 30, 1998

In April of 1999, the Company restated its 1998 financial  statements to reflect
the  accretion  on the Series A  convertible  preferred  stock and  $600,000  of
general and  administrative  expense related to common stock issuable to Pillar.
The following table presents the net income (loss), net income (loss) applicable
to common  stockholders and net income (loss) per share as originally  reported,
and as restated.

<TABLE>
<CAPTION>

                                      Three Months Ended                             Six Months Ended
                                         June 30, 1998                                June 30, 1998

                              As Reported            As Restated            As Reported            As Restated
                              -----------            -----------            -----------            -----------
<S>                            <C>                   <C>                    <C>                    <C>    

Net Income (Loss)             $ 1,650,245            $ 1,050,245           $ (7,031,927)          $ (7,631,927)

Net Income (Loss)
applicable to common
stockholders                    1,650,245                429,745             (7,031,927)            (8,252,427)

Net Income (Loss) per
share                              $ 0.15                 $ 0.04                $ (0.86)               $ (1.01)

</TABLE>


<PAGE>

LIQUIDITY AND CAPITAL RESOURCES

During  the six months  ended  June 30,  1998,  the  Company's  net cash used in
operating  activities  amounted to  $12,914,000.  The Company's  operating  cash
requirements  were funded  primarily  through the  utilization of existing cash,
proceeds from the Company's private placement  described in Item 2 of Part II of
this Quarterly Report on Form 10-Q and in Note 1 to the  Consolidated  Condensed
Financial  Statements  in Item 1.  hereof and the sale of excess  equipment.  In
addition,  a portion of the Company's restricted cash was utilized to reduce the
related debt and capital lease obligations.

Based on its current  operating plan (which includes the sale of its interest in
its former Cambridge headquarters (the "Cambridge Headquarters  Facility"),  and
certain sales of equipment  and  furniture  (collectively,  the  "Sales")),  the
Company  believes that its existing capital  resources,  together with committed
collaborative  research and development payments from G.D. Searle & Co., certain
research and development funding expected to be received from MethylGene,  Inc.,
anticipated sales by the Company's HSP Division and anticipated  margins on such
sales,  and the anticipated net proceeds of the Sales,  will be adequate to fund
the Company's capital requirements through 1998. The operating plan is based, in
part,  on the  assumption  that the Company will be relieved of its  obligations
under its lease for the  Cambridge  Headquarters  Facility  and that the Company
will  receive  funds  from the sale of its  limited  partnership  interest  (the
"Limited  Partnership  Interest") in Charles River Building Limited Partnership,
the entity  which  owns the  Cambridge  Headquarters  Facility  (the  "Cambridge
Landlord"),  by the end of  September  1998.  The  Cambridge  Landlord is in the
process of both re-leasing the Cambridge  Headquarters Facility to a third party
and selling the Cambridge Headquarters Facility and has advised the Company that
it expects to complete such transactions by such date.

The  Company  has the right at any time prior to  February  2000 to require  the
other  limited  partners  in the  Cambridge  Landlord  to  purchase  its Limited
Partnership  Interest.  In April  1998,  the  Company  exercised  this right and
anticipates receiving approximately  $4,000,000 from such sale, which it expects
will be funded from the Cambridge Landlord's sale of the Cambridge  Headquarters
Facility.  In addition,  the Company expects to receive its security  deposit of
approximately  $1,700,000 from the Cambridge Landlord. There can be no assurance
as to the timing of such receipt, although the Company has been informed that it
should receive such funds by September 1998.

The  Company and Silicon  Valley  Bank have agreed in  principle  to amend their
credit agreement as follows:  (i) the minimum liquidity and minimum tangible net
worth  covenants  will not be tested until the earlier of (x) September 30, 1998
and (y) the date of the  Company's  receipt of the sale  proceeds of the Limited
Partnership Interest (the "Proceeds");  (ii) the minimum liquidity covenant will
be revised, including the removal of the $8,000,000 testing threshold, and (iii)
the Company will prepay  $1,592,386 of the loan upon execution of the definitive
agreement and will prepay an  additional  $750,000 upon receipt of the Proceeds.
The Company expects to enter into such definitive agreement in the near future.

The Company  will be  required to raise  substantial  additional  funds  through
external sources,  including through  collaborative  relationships and public or
private  financings,  to support its  operations  and,  except for  research and
development  funding  from  Searle  (which is  subject to early  termination  in
certain circumstances),  certain research and development funding expected to be
received  from   MethylGene,   Inc.  and  sale  of  DNA  products  and  reagents
manufactured  on a custom  contract  basis by the HSP Division,  Hybridon has no
current external sources of capital, and, as discussed above, expects no product
revenues  for  at  least  several  years  from  sales  of  products  that  it is
developing.





<PAGE>

No assurance can be given that such  additional  funds will be available to fund
the Company's operations or, if available,  that such funds will be available on
acceptable  terms. If additional funds are raised by issuing equity  securities,
further dilution to then existing  stockholders will result.  Additionally,  the
terms of any such  additional  financing  may  adversely  affect the holdings or
rights of then existing stockholders.

If  adequate  funds are not  available,  the  Company may be required to further
curtail significantly one or more of its core drug development programs,  obtain
funds  through  arrangements  with  collaborative  partners  or others  that may
require the Company to relinquish rights to certain of its technologies, product
candidates or products  which the Company would  otherwise  pursue on its own or
terminate operations.

The Company's future capital requirements will depend on many factors, including
continued  scientific  progress in its research,  drug discovery and development
programs,  the  magnitude  of these  programs,  progress  with  preclinical  and
clinical trials,  sales of DNA products and reagents to third parties by the HSP
Division and the margins on such sales, the time and costs involved in obtaining
regulatory  approvals,  the costs involved in filing,  prosecuting and enforcing
patent claims,  competing technological and market developments,  the ability of
the Company to establish  and  maintain  collaborative  academic and  commercial
research, development and marketing relationships, the ability of the Company to
obtain  third-party  financing  for  leasehold  improvements  and other  capital
expenditures  and the  costs of  manufacturing  scale-up  and  commercialization
activities and arrangements.






<PAGE>

                                 HYBRIDON, INC.

                                     PART II

                                OTHER INFORMATION

                                     -------

Item 2.     Changes in Securities and Use of Proceeds
- -------     -----------------------------------------


            During the quarter ended June 30, 1998,  the Company issued and sold
the following  securities  that were not registered  under the Securities Act of
1933, as amended (the "Securities Act"):

            I.  Unregistered Offerings Pursuant to Section 4(2) Under the 
                Securities Act
                ---------------------------------------------------------

            The  securities  issued in each of the following  transactions  were
offered and sold in reliance upon the exemption from registration  under Section
4(2) of the  Securities  Act,  relating  to sales by an issuer not  involving  a
public  offering.  The securities  issued in each of the following  transactions
were offered and sold solely to persons who were "accredited  investors" as that
term is defined in Regulation D promulgated under the Securities Act.


(1)         On May 5, 1998, the Company accepted $48,694,000 principal amount of
its 9% Convertible  Subordinated Notes Due 2004 (the "9% Notes") tendered to the
Company in exchange for 510,505 shares of series A preferred  stock (the "Series
A Preferred Stock") and warrants (the "Class A Warrants") to purchase  3,002,958
shares of common stock, par value $.001 per share (the "Common  Stock"),  of the
Company (the  "Exchange  Offer").  As a result of the Exchange  Offer,  there is
$1,306,000 in principal amount of the 9% Notes outstanding.

            Pursuant to the Exchange Offer, which commenced on February 6, 1998,
all tendering  Noteholders  received per $1,000 principal amount of the 9% Notes
(including  accrued but unpaid interest on the 9% Notes) (i) 10 shares of Series
A Preferred Stock and (ii) Class A Warrants to purchase such number of shares of
Common Stock equal to 25% of the number of shares of the Company's  Common Stock
into which the Series A Preferred  Stock issued to such  Noteholder  pursuant to
the Exchange Offer would be convertible.

            The Series A Preferred  Stock ranks, as to dividends and liquidation
preference,  senior to the Company's  Common Stock. The Series A Preferred Stock
issued in this Exchange Offer and in the Preferred  Stock  Offering,  as defined
below,  will be  convertible  into an aggregate of  14,700,941  shares of Common
Stock, subject to adjustment, beginning May 5, 1999.

            The Class A Warrants will be  exercisable  commencing on May 5, 1999
for a period of four  years  thereafter  at $4.25  per  share of  Common  Stock,
subject to adjustment. The Class A Warrants are not subject to redemption at the
option of the Company under any circumstances.




                                        1

<PAGE>

            The  Exchange  Offer was  undertaken  by the  Company as part of the
Company's  new  business  plan  contemplating  a  restructuring  of its  capital
structure to reduce debt service  obligations,  a  significant  reduction in its
burn rate and an infusion of additional equity capital.


(2)         On  May 5,  1998,  the  Company  closed  a  private  placement  (the
"Preferred  Stock  Offering") of (i) 114,285 shares of Series A Preferred Stock,
which sold at $70 per share,  and (ii) class D warrants (the "Class D Warrants")
to purchase 672,273 shares of the Company's Common Stock, subject to adjustment,
for an aggregate amount of approximately $8 million.

            The Class D Warrants will be  exercisable  commencing on May 5, 1999
until May 4, 2003 at $2.40 per share of Common Stock, subject to adjustment.

            The Company  retained  Forum  Capital  Markets,  LLC  ("Forum") as a
placement  agent of the Company in connection  with the Preferred Stock Offering
in the United States. As of the date hereof,  Forum has received as compensation
for its services as placement  agent with regard to the Preferred Stock Offering
and its assistance with the Exchange  Offer,  597,699 shares of Common Stock and
warrants to purchase  609,195  shares of Common Stock  exercisable  at $2.40 per
share,  in each case subject to adjustment,  until May 4, 2003. In addition,  in
consideration  of the agreements made by Forum  consenting to the Company's 1998
private  placements  described  below and  waiving  certain  obligations  of the
Company to Forum,  the Company agreed to amend Forum's warrant dated as of April
2, 1997,  to purchase up to 71,301 shares of Common Stock of the Company so that
the exercise price will be equal to $4.25 per share, and the number of shares of
Common Stock purchasable upon exercise thereof will be increased to 588,235,  in
each case subject to adjustment;  provided, however, that such warrant will also
be amended to provide that such  warrant may not be exercised  until May 5, 1999
and the transactions contemplated by such private placements and by the Exchange
Offer will not trigger  any  anti-dilution  adjustments  to the  exercise  price
thereof or the number of shares of Common Stock subject thereto.

            The net proceeds to the Company from the  Preferred  Stock  Offering
are  presently  intended to be used for general  corporate  purposes,  primarily
research  and  product  development  activities,  including  costs of  preparing
investigational  new drug  applications and conducting  preclinical  studies and
clinical trials,  the payment of payroll and other accounts payable and for debt
service  required under the Company's  debt  obligations.  The amounts  actually
expended  by the  Company  and  the  purposes  of  such  expenditures  may  vary
significantly  depending  upon numerous  factors,  including the progress of the
Company's  research,  drug discovery and  development  programs,  the results of
preclinical  studies and clinical  trials,  the timing of regulatory  approvals,
sales of DNA  products and reagents to third  parties  manufactured  on a custom
contract basis by the Hybridon  Specialty  Products Division and margins on such
sales, technological advances,  determinations as to the commercial potential of
the Company's  compounds and the status of  competitive  products.  In addition,
expenditures will also depend upon the  establishment of collaborative  research
arrangements with other companies, the availability of other financing and other
factors.  Under  certain  circumstances,  the Company may be required to use net
proceeds to repay  indebtedness  under its credit  agreement with Silicon Valley
Bank (the "Silicon Valley Bank Credit Facility").


(3)         On May 5, 1998, the Company closed a private placement of units (the
"Unit  Offering")  consisting of (i) 2,754,654  shares of Common Stock, and (ii)
class C warrants (the "Class C Warrants")



                                        2

<PAGE>

to  purchase  788,649  shares of Common  Stock,  subject  to  adjustment,  which
securities were issued in  consideration  of the  cancellation (or reduction) of
accounts payable, capital lease and other obligations aggregating $5,509,308.

            The Class C Warrants are exercisable at $2.40 per share,  subject to
adjustment from time to time, until May 4, 2003.

            The Common Stock issued pursuant to the Unit Offering and the Common
Stock  underlying the Class C Warrants are subject to a "lock-up"  period ending
on May 5, 1999,  except to the extent such  securities  are sold or  transferred
pursuant to a  Registration  Statement.  After the Company files a  Registration
Statement  under  the  Securities  Act,  75% of  each  holder's  Units  and  the
underlying  securities will be subject to an additional  "lock-up" for the first
three months  following the effective  date of the  Registration  Statement (the
"Effective  Date");  thereafter,  50% of such  securities  will be subject to an
additional  "lock-up"  until six months  following the Effective  Date;  and the
remaining 25% of such securities will be "locked-up" until nine months following
the Effective Date.


(4)         On May 5, 1998, the Company sold to Dr. Paul Zamecnik 100,000 shares
of Common Stock and Class C Warrants to purchase  25,000 shares of Common Stock,
subject to adjustment, for a purchase price of $200,000.

            The net  proceeds  of this  offering  were used to  reduce  accounts
payable, capital lease and other obligations.


(5)         On May 5, 1998, the Company  issued to certain  suppliers a total of
362,500  shares of Common  Stock and Class C  Warrants  to  purchase  a total of
90,625 shares of Common Stock.  These  issuances  were in  consideration  of (i)
payment to the Company of a total of  $362.50,  the par value of all such issued
Common Stock,  and (ii) the subsequent  furnishing of specified  services to the
Company by each  supplier.  The  extent to which the  suppliers  have  completed
performing the specified services varies.

            The Common  Stock  issued to Dr.  Paul  Zamecnik  and to the certain
suppliers and the Common Stock  underlying  the Class C Warrants  issued to such
persons are subject to a "lock-up"  period ending on May 5, 1999,  except to the
extent  such  securities  are sold or  transferred  pursuant  to a  Registration
Statement. After the Company files a Registration Statement under the Securities
Act, 75% of each holder's Units and the underlying securities will be subject to
an additional "lock-up" for the first three months following the Effective Date;
thereafter,  50% of such securities  will be subject to an additional  "lock-up"
until six months  following  the Effective  Date;  and the remaining 25% of such
securities will be "locked-up" until nine months following the Effective Date.


            II.  Unregistered Offerings Pursuant to Regulation S Under the 
                 Securities Act
                 ---------------------------------------------------------

            The  securities  issued by the Company in the each of the  following
transactions   were  offered  and  sold  in  reliance  upon  an  exemption  from
registration  under Regulation S promulgated  under the Securities Act, relating
to sales by an issuer in offshore transactions (the "Offshore  Offerings").  The
securities issued in each of the following  Offshore  Offerings were offered and
sold solely to persons who were  "accredited  investors" as that term is defined
in Regulation D promulgated under the Securities Act.



                                        3

<PAGE>

(1)         On January 15, 1998,  the Company  commenced a private  placement of
units (the "Units"), each Unit consisting of 14% Convertible  Subordinated Notes
Due 2007 (the "14% Notes") and  warrants  (the  "Equity  Warrants")  to purchase
shares of the Company's  Common Stock (the "14% Note  Offering").  The 14% Notes
were subject to both mandatory and optional  conversion  into shares of series B
preferred stock,  under certain  circumstances  which, in turn, were convertible
into Common Stock (the "Series B Preferred Stock").

            On January 23, 1998, as part of the 14% Note  Offering,  the Company
sold $2,230,000 in principal amount of 14% Notes and Equity Warrants.

            On February 9, 1998, as part of the 14% Note  Offering,  the Company
sold $2,384,000 in principal amount of 14% Notes and Equity Warrants.

            On March 27,  1998,  as part of the 14% Note  Offering,  the Company
sold $200,000 in principal amount of 14% Notes and Equity Warrants.

            On April 21,  1998,  as part of the 14% Note  Offering,  the Company
sold $300,000 in principal amount of 14% Notes and Equity Warrants.

            On April 24,  1998,  as part of the 14% Note  Offering,  the Company
sold $1,020,000 in principal amount of 14% Notes and Equity Warrants.

            In each of the above  closings,  the 14% Notes  were  issued at face
value.


(2)         On May 5, 1998, the Company closed a private  placement of 3,223,000
shares of Common Stock and class B warrants (the "Class B Warrants") to purchase
805,750  shares of the  Company's  Common  Stock,  subject  to  adjustment,  for
aggregate gross proceeds of $6,446,000.

            The Class B Warrants are  exercisable  for a period of five years at
$2.40 per share of Common Stock, subject to adjustment from time to time.

            The Common  Stock issued in such  private  placement  and the Common
Stock  underlying  the Class B Warrants  issued in such  private  placement  are
subject to a "lock-up" for a period ending on May 5, 1999,  except to the extent
such  securities  are sold or transferred  pursuant to a Registration  Statement
filed by the  Company  under  the  Securities  Act.  After the  Company  files a
Registration  Statement  under the Securities  Act, 75% of each holder's  Common
Stock,  including  the Common  Stock  underlying  the Class B Warrants,  will be
subject to an  additional  "lock-up"  for the first three months  following  the
Effective  Date;  thereafter,  50% of  such  securities  will be  subject  to an
additional  "lock-up"  until six months  following the Effective  Date;  and the
remaining 25% of such securities will be "locked-up" until nine months following
the Effective Date.


(3)         The Company has exchanged all of the 14% Notes issued, including any
right to interest thereon,  and all Equity Warrants issued together with the 14%
Notes,  for  3,157,322  shares of Common  Stock and Class B Warrants to purchase
947,195 shares of Common Stock.





                                        4

<PAGE>

            The  Company  has  retained  Pillar   Investments,   Ltd.   ("Pillar
Investments") as a placement agent of the Company in connection with the private
placements  of  securities  of the  Company in the  Offshore  Offerings.  Pillar
Investments  is  entitled  to  receive  fees  consisting  of (i) 9% of the gross
proceeds of each Offshore  Offering,  (ii) a  non-accountable  expense allowance
equal to 4% of such gross  proceeds,  (iii) the right to  purchase,  for nominal
consideration,  warrants  to  purchase  473,598  shares of Common  Stock,  at an
exercise  price of $2.40 per  share,  (iv) the right to  purchase,  for  nominal
consideration, warrants to purchase such number of shares of the Common Stock of
the Company equal to 10% of the aggregate  number of shares of Common Stock sold
by the Company for which Pillar Investments acts as placement agent, exercisable
at 120% of the relevant Common Stock offering price,  for a period of five years
(resulting,  as of the date hereof, in the right to receive warrants to purchase
638,032  shares  at  $2.40  per  share,  subject  to  adjustment),   and  (v)  a
consulting/restructuring  fee of $960,000 payable in Common Stock of the Company
valued at the  market  price and  payable  in three  equal  installments  as net
proceeds  of  $25,000,000,  $30,000,000  and  $35,000,000  are  received  in the
aggregate from private placements  effected by the Company in 1998 to the extent
contemplated  by the  Consent  dated as of January  12, 1998 given by certain 9%
Noteholders  of the  Company,  or otherwise  to the extent  contemplated  by the
Placement Agency Agreement between the Company and Pillar  Investments,  subject
to the Company's  receipt of a fairness  opinion with regard thereto,  provided,
however,  that in no event shall  Pillar  Investments  be  permitted  to receive
compensation  in excess of the level which was approved by the holders of the 9%
Notes.  Through the date hereof,  Pillar Investments has received  $1,635,400 in
cash pursuant to these arrangements.

            The Company and Pillar  Investments  have  entered  into an advisory
agreement   pursuant  to  which  Pillar   Investments   acts  as  the  Company's
non-exclusive  financial advisor,  which agreement provides that an affiliate of
Pillar  Investments  receive  a  monthly  retainer  of  $5,000  (with a  minimum
engagement  of 24 months  beginning on May 5, 1998),  and further  provides that
Pillar  Investments  is  entitled to receive (i)  out-of-pocket  expenses,  (ii)
subject to the  Company's  receipt of a fairness  opinion with respect  thereto,
300,000 shares of Common Stock in connection with Pillar Investments' efforts in
assisting the Company in restructuring its balance sheet, and (iii) certain cash
and equity success fees in the event Pillar  Investments  assists the Company in
connection with certain financial and strategic transactions.

            The net  proceeds to the Company  from the  Offshore  Offerings  are
presently intended to be used for general corporate purposes, primarily research
and product development activities, including costs of preparing investigational
new drug  applications and conducting  preclinical  studies and clinical trials,
the payment of payroll and other accounts  payable and for debt service required
under the  Company's  debt  obligations.  The amounts  actually  expended by the
Company and the purposes of such expenditures may vary  significantly  depending
upon numerous factors,  including the progress of the Company's  research,  drug
discovery  and  development  programs,  the results of  preclinical  studies and
clinical trials, the timing of regulatory  approvals,  sales of DNA products and
reagents  to  third  parties  manufactured  on a  custom  contract  basis by the
Hybridon  Specialty  Products Division and margins on such sales,  technological
advances,  determinations  as to  the  commercial  potential  of  the  Company's
compounds and the status of competitive products. In addition, expenditures will
also depend upon the establishment of collaborative  research  arrangements with
other companies,  the  availability of other financing and other factors.  Under
certain circumstances,  the Company may be required to use net proceeds to repay
indebtedness under the Silicon Valley Bank Credit Facility.





                                        5

<PAGE>

Item 4.     Submission of Matters to a Vote of Security Holders
- -------     ---------------------------------------------------

            At the Company's  Annual  Meeting of  Stockholders  held on June 15,
1998, the stockholders  re-elected the following three  individuals as Class III
Directors to hold office until the 2001 Annual Meeting of Stockholders:

                                    For         Against    Abstain
                                    ---         -------    -------
     Dr. Sudhir Agrawal           7,944,840     203,844       0
     Youssef El-Zein              7,942,216     206,468       0
     E. Andrews Grinstead         7,937,748     210,936       0

            The  term  of  office  as a  Director  for  each  of  the  following
individuals continued after the meeting:

            Nasser Menhall
            Mohamed A. El-Kheriji
            Dr. James B. Wyngaarden
            Dr. Paul C. Zamecnik

            Pursuant  to the  Company's  offer to  exchange  its 9%  Convertible
Subordinated  Notes due 2004 (the "9% Notes")  for Series A Preferred  Stock and
warrants,  exchanging  holders  of the 9% Notes had the right to  designate  one
person for nomination to the Company's Board of Directors. The exchanging holder
of the 9% Notes  selected  Arthur W. Berry as their  nominee  and Mr.  Berry was
appointed as a Class I Director.  Harold L. Purkey was also appointed as a Class
I Director.

            The  stockholders  also  approved a proposal to amend the  Company's
1997 Stock Incentive Plan. The holders of 6,422,087 shares of Common Stock voted
for the  proposal,  the holders of 239,056  shares of Common Stock voted against
the proposal, the holders of 21,209 shares of Common Stock abstained from voting
and the holders of 1,466,332 shares of Common Stock were broker non-votes.

            Finally, the stockholders  ratified the selection of Arthur Andersen
LLP as the independent  public  accountants to audit the Company's  consolidated
financial statements.  The holders of 8,137,125 shares of Common Stock voted for
the ratification,  the holders of 7,379 shares of Common Stock voted against and
the holders of 4,180 abstained from voting.




                                        6

<PAGE>

Item 6.     Exhibits and Reports on Form 8-K
- -------     --------------------------------


     (a)    Exhibits.
            27.1   Financial Data Schedule (EDGAR)

            The  following  exhibits  were  previously  filed  as  part  of  the
            Company's Form 10-Q for the quarter ended June 30, 1998.

            99.1   Second Amendment to Loan and Security Agreement between 
                   Hybridon,  Inc. and Silicon Valley Bank.

            99.2   Financial Advisory Agreement between Hybridon, Inc. and 
                   Pillar Investments, Ltd.

            99.3   Placement Agency Agreement between Hybridon, Inc. and Pillar 
                   Investments, Ltd.

     (b) The  following  Reports on Form 8-K were filed during the quarter ended
         June 30, 1998:

            1. On April 9, 1998,  the Company filed a Current Report on Form 8-K
            dated  April 9, 1998  reporting  the  closing  on March 27,  1998 of
            $200,000 of Offering Notes and Warrants pursuant to the terms of the
            Overseas Offering.

            2. On April 27, 1998, the Company filed a Current Report on Form 8-K
            dated  April 27,  1998,  reporting  the closing on April 21, 1998 of
            $300,000 of Offering Notes and Warrants pursuant to the terms of the
            Overseas Offering.

            3. On April 28, 1998, the Company filed a Current Report on Form 8-K
            dated  April 28,  1998,  reporting  the closing on April 24, 1998 of
            $1,020,000 of Offering  Notes and Warrants  pursuant to the terms of
            the Overseas Offering.

            4. On May 8, 1998,  the Company  filed a Current  Report on Form 8-K
            dated May 8, 1998, reporting, inter alia, the closing on May 5, 1998
            of   approximately   6.6   million   shares  of  Common   Stock  and
            approximately 114,300 shares of Series A Convertible Preferred Stock
            and that  approximately  $48.6  million  principal  amount of its 9%
            Notes were  tendered  to the  Company to be  exchanged  for Series A
            Preferred Stock.



                                        7

<PAGE>

                                   SIGNATURES

                                     -------


        Pursuant to the requirements of the Securities  Exchange Act of 1934, as
amended,  the  registrant has duly caused this report to be signed on its behalf
by the undersigned thereunto duly authorized.


                                     HYBRIDON, INC.


April 13, 1999                       /s/ E. Andrews Grinstead, III
- -------------                        ---------------------------------------
Date                                 E. Andrews Grinstead, III
                                     Chairman, President and Chief Executive
                                     Officer (Principal Executive Officer)


April 13, 1999                       /s/ Robert G. Andersen
- -------------                        ---------------------------------------
Date                                 Robert G. Andersen
                                     Treasurer (Principal Accounting and
                                     Financial Officer)




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