HYBRIDON INC
NTN 10K, 2000-05-04
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   FORM 12b-25

                        Commission File Number: 333-3954
                           NOTIFICATION OF LATE FILING

(Check One):      [X] Form 10-K   [_] Form 11-K   [_] Form 20-F    [_] Form 10-Q
                  [_] Form N-SAR

                  For Period Ended:  December 31, 1999

         [_]      Transition Report on Form 10-K
         [_]      Transition Report on Form 20-F
         [_]      Transition Report on Form 11-K
         [_]      Transition Report on Form 10-Q
         [_]      Transition Report on Form N-SAR
                  For the Transition Period Ended:  _________________________
   Read attached instruction sheet before preparing form.  Please print or type.

         Nothing in this form shall be construed to imply that the Commission
has verified any information contained herein.

         If the notification relates to a portion of the filing checked above,
identify the item(s) to which the notification relates:

                                     PART I
                             REGISTRANT INFORMATION

Hybridon, Inc
- -------------------------------------------------------------------------------
Full Name of Registrant


- -------------------------------------------------------------------------------
Former Name if Applicable

155 Fortune Boulevard
- -------------------------------------------------------------------------------
Address of Principal Executive Office (Street and Number)

Milford, MA 01757
- -------------------------------------------------------------------------------
City, State and Zip Code

                                     PART II
                             RULE 12b-25(b) AND (c)

         If the subject report could not be filed without unreasonable effort or
expense and the registrant seeks relief pursuant to Rule 12b-25(b), the
following should be completed. (Check box if appropriate.)

[X]     (a)       The reasons described in reasonable detail in Part III of this
                  form could not be eliminated without unreasonable effort or
                  expense;
[X]     (b)       The subject annual report, semi-annual report, transition
                  report on Form 10-K, Form 20-F, Form 11-K or Form N-SAR, or
                  portion thereof will be filed on or before the 15th calendar
                  day following the prescribed due date; or the subject
                  quarterly report or transition report on Form 10-Q, or portion
                  thereof will be filed on or before the fifth calendar day
                  following the prescribed due date; and

<PAGE>

[ ]     (c)       The accountant's statement or other exhibit required by Rule
                  12b-25(c) has been attached if applicable.

                                    PART III
                                    NARRATIVE

         State below in reasonable detail why the Form 10-K, 11-K, 20-F, 10-Q,
N-SAR or the transition report or portion thereof could not be filed within the
prescribed time period. (Attach extra sheets if needed.)

         The Registrant had intended to file the information  called for by Part
III  of  Form  10-K  through  use  of an  amendment  (the  "Amendment")  to  the
Registrant's  Form 10-K for the fiscal year ended December 31, 1999,  within the
time allowed  under General  Instruction  G.(3) to Form 10-K.  However,  several
factors  have  contributed  to the  untimely  filing  of the  Amendment.  First,
Registrant's  in-house  legal  counsel,  who was  responsible  for  managing the
Registrant's public filings, recently resigned.  Additionally, the President and
Chief  Executive  Officer of the  Registrant,  E.  Andrews  Grinstead,  III, was
recently  diagnosed with a serious illness and forced to take a leave of absence
from the Registrant.  Consequently, Mr. Grinstead has been unable to devote time
and attention to the management and affairs of the Registrant.  As a result, the
two remaining executive officers have been required,  in addition to their other
duties, to discharge the  responsibilities  formerly discharged by the President
and Chief Executive Officer.  These personnel shortages have been exacerbated by
management's  recent  need to  devote  substantial  time  and  attention  to the
negotiation of a proposed transaction material to the continued viability of the
Registrant.  All of the above have  contributed to the  Registrant's  inability,
without  unreasonable  effort or expense, to complete the Amendment on or before
the date on which it was  required  to be  filed.  The  Amendment  will be filed
within the period specified by paragraph (b)(2)(ii) of Rule 12b-25.

                                     PART IV
                                OTHER INFORMATION

(1)      Name and telephone number of person to contact in regard to this
         notification

         Robert Andersen                 508               482-7500
         -----------------------------------------------------------------------
             (Name)                    (Area Code)       (Telephone Number)

(2)      Have all other periodic reports required under Section 13 or 15(d) of
         the Securities Exchange Act of 1934 or Section 30 of the Investment
         Company Act of 1940 during the preceding 12 months or for such shorter
         period that the registrant was required to file such report(s) been
         filed? If the answer is no, identify report(s).
                                                           [X] Yes     [_] No

(3)      Is it anticipated that any significant change in results of operations
         from the corresponding period for the last fiscal year will be
         reflected by the earnings statements to be included in the subject
         report or portion thereof?
                                                           [ ] Yes     [X] No

         If so: attach an explanation of the anticipated change, both
narratively and quantitatively, and, if appropriate, state the reasons why a
reasonable estimate of the results cannot be made.


                                      -2-


<PAGE>

                                 Hybridon, Inc.
               ---------------------------------------------------
                  (Name of Registrant as Specified in Charter)

Has caused this notification to be signed on its behalf by the undersigned
thereunto duly authorized.

Date: May 4, 2000                        By:  /s/ Robert Andersen
      --------------                           ---------------------------------
                                              Name:  Robert Andersen
                                              Title: Vice President

         INSTRUCTION: The form may be signed by an executive officer of the
registrant or by any other duly authorized representative. The name and title of
the person signing the form shall be typed or printed beneath the signature. If
the statement is signed on behalf of the registrant by an authorized
representative (other than an executive officer), evidence of the
representative's authority to sign on behalf of the registrant shall be filed
with the form.

                                    ATTENTION

         Intentional misstatements or omissions of fact constitute Federal
Criminal Violations (see 18 U.S.C. 1001).

                              GENERAL INSTRUCTIONS

         1. This form is required by Rule 12b-25 of the General Rules and
Regulations under the Securities Exchange Act of 1934.

         2. One signed original and four conformed copies of this form and
amendments thereto must be completed and filed with the Securities and Exchange
Commission, Washington, D.C. 20549, in accordance with Rule 0-3 of the General
Rules and Regulations under the Act. The information contained in or filed with
the form will be made a matter of public record in the Commission files.

         3. A manually signed copy of the form and amendments thereto shall be
filed with each national securities exchange on which any class of securities of
the registrant is registered.

         4. Amendments to the notifications must also be filed on Form 12b-25
but need not restate information that has been correctly furnished. The form
shall be clearly identified as an amended notification.

         5. ELECTRONIC FILERS. This form shall not be used by electronic filers
unable to timely file a report solely due to electronic difficulties. Filers
unable to submit a report within the time period prescribed due to difficulties
in electronic filing should comply with either Rule 201 or Rule 202 of
Regulation S-T or apply for an adjustment in filing date pursuant to Rule 13(b)
of Regulation S-T.

(Form 12b-25-07/98)


                                      -3-




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