HYBRIDON INC
10-Q, 2000-08-14
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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     As filed with the Securities and Exchange Commission on August 14, 2000

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 10-Q


[X]    QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
       EXCHANGE ACT OF 1934

For the quarterly period ended June 30, 2000, or

[ ]    TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
       EXCHANGE ACT OF 1934

For transition period from _________________.

Commission File Number 0-27352

                                 HYBRIDON, INC.
             (Exact name of registrant as specified in its charter)

           Delaware                                           04-3072298
(State or other jurisdiction of                             (I.R.S. Employer
incorporation or organization)                            Identification Number)


                                155 Fortune Blvd.
                          Milford, Massachusetts 07157
                    (Address of principal executive offices)

                                 (508) 482-7500
              (Registrant's telephone number, including area code)


Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for such shorter period that the registrant was
required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days.

                                  Yes [X}   No__


Indicate the number of shares outstanding of each of the issuer's classes of
common stock, as of the latest practicable date.

Common Stock, par value $.001 per share                    17,789,444
---------------------------------------         --------------------------------
Class                                           Outstanding as of August 4, 2000

<PAGE>

                                 HYBRIDON, INC.

                                    FORM 10-Q

                                      INDEX


PART I - FINANCIAL STATEMENTS

Item 1-  Financial Statements

              Consolidated Condensed Balance Sheets as of June 30, 2000 and
              December 31,1999.

              Consolidated Condensed Statements of Operations for the Three
              Months and Six Months ended June 30, 2000 and 1999.

              Consolidated Condensed Statements of Cash Flows for the Six Months
              ended June 30, 2000 and 1999.

              Notes to Consolidated Condensed Financial Statements.

Item 2 -      Management's Discussion and Analysis of Financial Condition and
              Results of Operations.

Item 3 -      Quantitative and Qualitative Disclosure About Market Risk.


PART II - OTHER INFORMATION

Items 1-3     -   None
Item 4        -   Matters to a Vote of Security Holders
Item 5        -   None
Item 6        -   Exhibits and Reports on Form 8-K

Signatures


<PAGE>
<TABLE>
<CAPTION>

                         HYBRIDON, INC. AND SUBSIDIARIES

                      CONSOLIDATED CONDENSED BALANCE SHEETS

                                   (UNAUDITED)

                                     ASSETS
                                                                                  June 30,       December 31,
                                                                                    2000            1999
                                                                                    ----            ----
CURRENT ASSETS:
<S>                                                                          <C>                 <C>
   Cash and cash equivalents                                                 $     310,129       $   2,551,671
   Prepaid expenses and other current assets                                        46,092             101,914
                                                                             -------------       -------------
         Total current assets                                                      356,221           2,653,585
                                                                             -------------       -------------
PROPERTY AND EQUIPMENT, AT COST:
   Leasehold improvements                                                          150,342             150,342
   Laboratory and other equipment                                                5,200,727           5,249,620
                                                                             -------------       -------------
                                                                                 5,351,069           5,399,962

   Less--Accumulated depreciation and amortization                               5,259,432           5,229,514
                                                                             -------------       -------------
                                                                                    91,637             170,448
                                                                             -------------       -------------
OTHER ASSETS:
   Deferred financing costs and other assets                                     1,196,587           1,325,149
   Notes receivable from officers                                                  275,750             270,050
                                                                             -------------       -------------
                                                                                 1,472,337           1,595,199
                                                                             -------------       -------------

NET ASSETS FROM DISCONTINUED OPERATIONS                                          5,005,380           6,091,025
                                                                             -------------       -------------
                                                                             $   6,925,575       $  10,510,257
                                                                             =============       =============

                      LIABILITIES AND STOCKHOLDERS' DEFICIT
CURRENT LIABILITIES:
   Current portion of long-term debt                                         $  13,736,943       $   6,000,000
   Accounts payable                                                                837,343           1,081,796
   Accrued expenses                                                              1,931,108           2,094,988
                                                                             -------------       -------------
         Total current liabilities                                              16,505,394           9,176,784
                                                                             -------------       -------------
9% CONVERTIBLE SUBORDINATED NOTES PAYABLE                                        1,306,000           1,306,000
                                                                             -------------       -------------
8% CONVERTIBLE SUBORDINATED NOTES PAYABLE                                                -           6,099,776
                                                                             -------------       -------------
STOCKHOLDERS' DEFICIT:
   Preferred stock, $.01 par value-
     Authorized--5,000,000 shares
     Series A convertible preferred stock-
         Designated - 1,500,000 shares
         Issued and outstanding--628,115 and 661,856 shares at June 30,
         2000 and December 31, 1999, respectively                                    6,281               6,618
            (Liquidation preference of $63,799,772 at June 30, 2000)
   Common stock, $.001 par value-
     Authorized--100,000,000 shares
     Issued and outstanding - 17,610,779 and 16,260,722 shares at June 30,
     2000 and December 31, 1999, respectively                                       17,611              16,261
   Additional paid-in capital                                                  249,924,660         247,813,331
   Accumulated deficit                                                        (260,413,161)       (253,183,130)
   Deferred compensation                                                          (421,210)           (725,383)
                                                                             -------------       -------------
         Total stockholders' deficit                                           (10,885,819)         (6,072,303)
                                                                             -------------       -------------
                                                                             $   6,925,575       $  10,510,257
                                                                             =============       =============
</TABLE>

           The accompanying notes are an integral part of these consolidated
condensed financial statements.

                                                        1

<PAGE>
<TABLE>
<CAPTION>

                         HYBRIDON, INC. AND SUBSIDIARIES

                 CONSOLIDATED CONDENSED STATEMENTS OF OPERATIONS

                                   (UNAUDITED)

                                                  Three Months Ended                  Six Months Ended
                                                       June 30,                           June 30,
                                                2000             1999              2000              1999
                                                ----             ----              ----              ----
REVENUES:
<S>                                        <C>              <C>              <C>               <C>
  Service revenue                          $           -   $        72,500   $            -    $      182,500
  Research and development                             -           150,000          45,000            300,000
  Interest income                                 15,734            16,383          50,375             69,184
  Royalty and other income                        25,189            14,755          57,637             54,980
                                          --------------   ---------------  --------------     --------------
                                                  40,923           253,638         153,012            606,664
                                          --------------   ---------------  --------------     --------------
OPERATING EXPENSES:
   Research and development                      859,955         1,019,076       2,032,722          2,417,151
    General and administrative                   874,691           940,987       1,777,884          2,062,455
   Interest                                      558,928           150,123         905,004            302,949
                                          --------------   ---------------  ---------------    --------------
                                               2,293,574         2,110,186       4,715,610          4,782,555
                                          --------------   ---------------  --------------     --------------

   Net loss from continuing operations        (2,252,651)       (1,856,548)     (4,562,598)        (4,175,891)
                                          ---------------  ---------------   -------------     --------------

   Net loss from discontinued operations        (181,931)         (777,905)       (575,946)        (1,424,754)
                                          --------------   ---------------   -------------     --------------

NET LOSS                                  $   (2,434,582)  $    (2,634,453)  $  (5,138,544)    $   (5,600,645)
                                          ---------------  ---------------   -------------     --------------

ACCRETION OF PREFERRED STOCK DIVIDENDS         1,020,687         1,075,900       2,091,487          2,117,952
                                          --------------   ---------------   -------------     --------------
NET LOSS APPLICABLE TO COMMON
STOCKHOLDERS                              $  (3,455,269)   $    (3,710,353)  $  (7,230,031)    $   (7,718,597)
                                          =============    ===============   =============     ==============
BASIC AND DILUTED LOSS PER COMMON
SHARE  FROM (Note 3):

      Continuing Operations               $     (0.13)         $ (0.12)         $ (0.27)          $ (0.27)
      Discontinued Operations                   (0.01)           (0.05)           (0.03)            (0.09)
                                          ------------     ------------     ------------      ------------

   NET LOSS PER SHARE                           (0.14)           (0.17)           (0.31)            (0.36)
   ACCRETION OF PREFERRED STOCK
   DIVIDENDS                                    (0.06)           (0.07)           (0.12)            (0.14)
                                          ------------     ------------     ------------      ------------

   NET LOSS PER SHARE APPLICABLE TO
   COMMON STOCKHOLDERS                        $ (0.20)         $ (0.24)         $ (0.43)          $ (0.50)
                                              ========         ========         ========          ========

SHARES USED IN COMPUTING BASIC AND
DILUTED NET LOSS PER COMMON SHARE (Note
3)                                           17,243,450         15,661,492      16,758,985         15,483,158
                                           ============    ===============   =============     ==============

           The accompanying notes are an integral part of these consolidated condensed financial statements
</TABLE>

                                                            2

<PAGE>
<TABLE>
<CAPTION>

                         Hybridon, Inc. and Subsidiaries

                 CONSOLIDATED CONDENSED STATEMENTS OF CASH FLOWS

                                   (UNAUDITED)

                                                                            Six Months Ended
                                                                                June 30,
                                                                          2000             1999
CASH FLOWS FROM OPERATING ACTIVITIES:
<S>                                                                 <C>               <C>
   Net loss                                                         $    (5,138,544)  $    (5,600,645)
   Net loss from discontinued operations                                   (575,946)       (1,424,754)
                                                                    ----------------  ----------------
   Net loss from continuing operations                                   (4,562,598)       (4,175,891)

   Adjustments to reconcile net loss to net cash used in
   operating activities-
     Depreciation and amortization                                           78,811           303,745
     Amortization of deferred compensation                                  304,173           441,452
     Amortization of deferred financing costs                               229,963            53,967
     Non-cash interest expense                                              151,077                 -
     Changes in operating assets and liabilities-
       Prepaid and other current assets                                      55,822             8,677
       Notes receivable from officers                                        (5,700)           (5,700)
       Accounts payable and accrued expenses                               (408,333)         (644,958)
                                                                    ----------------  ----------------

              Net cash used in continuing operating activities           (4,156,785)       (4,018,708)
                                                                    ----------------  ----------------
             Net cash provided by/(used in) discontinued
             operations                                                     509,699          (269,551)
                                                                    ---------------   ----------------
CASH FLOWS FROM INVESTING ACTIVITIES:
   Increase in other assets                                                (101,401)                -
   Purchases of property and equipment, net                                       -            (8,302)
                                                                    ---------------   ----------------
              Net cash used in investing activities                        (101,401)           (8,302)
                                                                    ----------------  ----------------
CASH FLOWS FROM FINANCING ACTIVITIES:
   Net proceeds from issuance of common stock                                20,855                 -
   Proceeds from issuance of convertible promissory notes payable         1,486,090                 -
                                                                    ---------------   ---------------

              Net cash provided by financing activities                   1,506,945                 -
                                                                    ---------------   ---------------

NET DECREASE IN CASH AND CASH EQUIVALENTS                                (2,241,542)       (4,296,561)
CASH AND CASH EQUIVALENTS, BEGINNING OF  PERIOD                           2,551,671         5,607,882
                                                                    ---------------   ---------------

CASH AND CASH EQUIVALENTS, END OF PERIOD                            $       310,129   $     1,311,321
                                                                    ===============   ===============
SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION:
   Cash paid for interest                                           $       592,898   $       337,394
                                                                    ===============   ===============
SUPPLEMENTAL DISCLOSURE OF NON CASH ACTIVITIES:
   Accretion of Series A convertible preferred stock dividend       $     2,091,487   $     2,117,952
                                                                    ===============   ===============
   Issuance of common stock in lieu of services                     $             -   $     1,000,000
                                                                    ===============   ===============
</TABLE>

           The accompanying notes are an integral part of these consolidated
condensed financial statements.

                                                          3

<PAGE>

                         Hybridon, Inc. and Subsidiaries

              NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS

                                   (UNAUDITED)


(1)    ORGANIZATION

       Hybridon, Inc. (the Company) was incorporated in the State of Delaware on
       May 25, 1989. The Company is engaged in the discovery and development of
       novel genetic medicines based primarily on antisense technology.

       Since inception, the Company has been engaged primarily in research and
       development efforts, development of its manufacturing capabilities and
       organizational efforts, including recruiting of scientific and management
       personnel and raising capital. To date, the Company has not received
       revenue from the sale of biopharmaceutical products developed by it based
       on antisense technology. In order to commercialize its own products, the
       Company will need to address a number of technological challenges and
       comply with comprehensive regulatory requirements. Accordingly, it is not
       possible to predict the amount of funds that will be required or the
       length of time that will pass before the Company receives revenues from
       sales of any of these products. All revenues received by the Company to
       date have been derived from collaboration and licensing agreements,
       interest on investment funds and revenues from the custom contract
       manufacturing of synthetic DNA and reagent products by the Company's
       Hybridon Specialty Products business.

       On June 29, 2000, the Company entered into an Asset Purchase Agreement
       (see Note 9) to sell the assets of its Hybridon Specialty Products
       business to Boston Biosystems, Inc., a Delaware corporation which is a
       wholly owned subsidiary of Avecia, Inc., for an amount up to $15.0
       million (this sale, the Asset Sale). Consummation of the Asset Sale is
       subject to approval by the Company's Common and Preferred shareholders.

       On May 30, 2000, the Company entered into a Line of Credit Agreement (see
       Note 8) pursuant to which certain lenders (the LOC Lenders) agreed to
       provide the Company with an 8%, $2.0 million credit facility (the Line of
       Credit or LOC) which is intended to provide the Company with working
       capital pending the closing of the Asset Sale. On July 10, 2000, the
       Company drew down approximately $0.5 million under the Line of Credit.

       The Company's existing cash resources, including the LOC, are expected to
       be sufficient to fund operations into the fourth quarter of 2000. The
       Company expects the Asset Sale to be completed by the end of September
       2000. If the Asset Sale is not completed, the Company's existing cash
       resources and the LOC may not be sufficient to fund its operations and
       permit the company to avoid a default under one or more of its
       outstanding debt obligations. The Company's ability to continue
       operations would then depend on the willingness of its obligors to waive
       any such default and on its success in obtaining new funding from future
       sales of equity securities, debt financings and research and development
       collaborations.


                                       4

<PAGE>

 (2)   UNAUDITED INTERIM FINANCIAL STATEMENTS

       The unaudited consolidated condensed financial statements included herein
       have been prepared by the Company, without audit, pursuant to the rules
       and regulations of the Securities and Exchange Commission and include, in
       the opinion of management, all adjustments, consisting of normal,
       recurring adjustments, necessary for a fair presentation of interim
       period results. Certain information and footnote disclosures normally
       included in financial statements prepared in accordance with generally
       accepted accounting principles have been condensed or omitted pursuant to
       such rules and regulations. The Company believes, however, that its
       disclosures are adequate to make the information presented not
       misleading. The results for the interim periods presented are not
       necessarily indicative of results to be expected for the full fiscal
       year. The financial statements of the Company have been restated to
       reflect the financial results of the Hybridon Specialty Products business
       as a discontinued operation for the periods ended June 30, 1999, and
       December 31, 1999. It is suggested that these financial statements be
       read in conjunction with the audited consolidated financial statements
       and notes thereto included in the Company's Annual Report on Form 10-K
       for the year ended December 31, 1999, as filed with the Securities and
       Exchange Commission.

(3)    SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

       Net Loss per Common Share

       The Company follows the provisions of Statement of Financial Accounting
       Standards (SFAS) No. 128, Earnings per Share. Under SFAS No. 128, basic
       net loss per share applicable to common shareholders is computed using
       the weighted average number of shares of common stock outstanding during
       the period. Diluted net loss per common share is the same as basic net
       loss per common as the effects of the Company's potential common stock
       equivalents are antidilutive. The Company's potential common stock
       equivalents as of June 30, 2000 include 6,102,532 shares of common stock
       options and 13,277,365 shares of common stock warrants.

       Comprehensive Loss

       The Company follows the provisions of SFAS No. 130, Reporting
       Comprehensive Income. Comprehensive loss is defined as the change in
       equity of a business enterprise during a period from transactions and
       other events and circumstances from nonowner sources. The Company's
       comprehensive loss is the same as the reported net loss for all periods
       presented.

       Segment Reporting

       The Company follows the provisions of SFAS No. 131, Disclosures About
       Segments of an Enterprise and Related Information. SFAS No. 131
       establishes standards for reporting information regarding operating
       segments in annual financial statements and requires selected information
       for those segments to be reported in interim financial reports issued to
       stockholders. SFAS No. 131 also establishes standards for related
       disclosures about products and services and geographic areas. To date,
       the Company has viewed its operations and manages its business as
       principally one operating segment. As a result, the financial information
       disclosed herein, represents all of the material financial information
       related to the Company's principal operating segment. All of the
       Company's revenues are generated in the United States and substantially
       all assets are located in the United States.

                                       5

<PAGE>


       Reclassification

       Certain prior year account balances have been reclassified to be
consistent with current year's presentation.

(4)    CASH EQUIVALENTS

       The Company considers all highly liquid investments with maturities of
       ninety days or less when purchased to be cash equivalents. Cash and cash
       equivalents at June 30, 2000 and December 31, 1999 consisted of the
       following (at amortized cost, which approximates fair market value):

                                                  June 30,      December 31,
                                                    2000           1999
                                                    ----           ----
          Cash and cash equivalents-
             Cash and money market funds      $    214,278     $     505,794
             Corporate bonds                        95,851         2,045,877
                                              ------------     -------------
                                              $    310,129     $   2,551,671
                                              ============     =============


(5)    9.0% CONVERTIBLE SUBORDINATED NOTES

       On April 2, 1997, the Company issued $50.0 million of 9.0% convertible
       subordinated notes (the 9% Notes). On May 5, 1998 noteholders holding
       $48.6 million of principal value of the 9% Notes tendered such notes in
       exchange for Series A convertible preferred stock. Approximately
       $2,355,000 of accrued interest thereon was converted into shares of
       Series A convertible preferred stock and warrants to purchase common
       stock. As of June 30, 2000, there is $1.3 million of 9% Notes
       outstanding. Under the terms of the 9% Notes, the Company must make
       semi-annual interest payments on the outstanding principal balance
       through the maturity date of April 1, 2004. The 9% Notes are convertible
       at any time prior to the maturity date at a conversion price equal to
       $35.0625 per share, subject to adjustment under certain circumstances, as
       defined.

       Beginning April 1, 2000, the Company may redeem the 9% Notes at its
       option for a 4.5% premium over the original issuance price, provided that
       from April 1, 2000 to March 31, 2001, the 9% Notes may not be redeemed
       unless the closing price of the common stock equals or exceeds 150% of
       the conversion price for a period of at least 20 out of 30 consecutive
       trading days and the 9% Notes are redeemed within 60 days after such
       trading period. The premium decreases by 1.5% each year through March 31,
       2003. Upon a change of control of the Company, as defined, the Company
       will be required to offer to repurchase the 9% Notes at 150% of the
       original issuance price.

(6)    $6.0 MILLION LOAN

       During November 1998, the Company obtained a $6.0 million loan pursuant
       to a loan agreement with Forum Capital Markets, LLC (Forum) and certain
       investors associated with Pecks Management Partners Ltd. (collectively,
       the Lender). The terms of the loan are as follows: (i) the maturity is
       November 30, 2003; (ii) the interest rate is 8%; (iii) interest is
       payable monthly in arrears, with the principal due in full at maturity of
       the loan; (iv) the loan is convertible, at the Lender's option, in whole
       or in part, into shares of common stock at a rate equal to $2.40 per
       share; (v) the loan agreement includes covenants to maintain minimum
       liquidity of $2.0 million and minimum tangible net worth of $6.0 million;
       and (vi) the loan may not be prepaid, in whole or in part, at any time
       prior to December 1, 2000. The Company is not in compliance with the
       minimum

                                       6

<PAGE>

       tangible net worth requirement or the minimum liquidity covenant, but it
       has received waivers of noncompliance with these covenants through
       September 30, 2000. The Company has classified the outstanding balance of
       $6.0 million at June 30, 2000 as a current liability in the accompanying
       consolidated balance sheet as it does not expect to remain in compliance
       with the financial covenants. For its role in arranging the loan
       agreement, Forum received $0.4 million, which Forum reinvested by
       purchasing 160,000 shares of common stock with 40,000 attached warrants
       with an exercise price of $3.00 per share. The Company has recorded the
       $0.4 million as a deferred financing cost, which will be amortized to
       interest expense over the term of the note. In addition, Forum received
       warrants to purchase 133,333 shares of common stock of the Company at
       $3.00 per share. The Company computed the value of the warrants to be
       $85,433, using the Black-Scholes option-pricing model. The Company has
       recorded this $85,433 as a deferred financing cost, which will be
       amortized to interest expense over the term of the note.

(7)    8.0% CONVERTIBLE SUBORDINATED NOTES

       In March 2000, the Company completed its offering of the 8% Convertible
       Subordinated Notes (the 8% Convertible Notes). As of June 30, 2000, the
       Company had received approximately $7.6 million in principal with respect
       to the 8% Convertible Notes. Under the terms of the 8% Convertible Notes,
       the Company must make semiannual interest payments on the outstanding
       principal balance through the maturity date of November 30, 2002. The 8%
       Convertible Notes are convertible at any time prior to the maturity date
       at a conversion price equal to $0.60 per share of common stock (the
       Conversion Ratio), subject to adjustment under certain circumstances, as
       defined. If the 8% Convertible Notes are prepaid before the maturity
       date, all noteholders are entitled to receive warrants to purchase the
       number of shares of common stock equal to the number of shares of common
       stock that would be issued using the Conversion Ratio, with an exercise
       price of $0.60 per share of common stock.

       In connection with the 8% Convertible Notes, the Company must comply with
       certain covenants. These covenants include, without limitation, the
       requirement that the Company make all payments of interest when due and
       maintain consolidated cash balances of at least $1.5 million as of the
       last day of any calendar month. While as of June 30, 2000, the Company is
       not in compliance with the covenant regarding consolidated cash balances,
       it has received waivers of noncompliance. Because there is no guaranty
       that the Company will receive waivers in the future, the Company has
       classified the outstanding balance on the 8% Convertible Notes as a
       current liability in the accompanying consolidated balance sheet as of
       June 30, 2000. If an event of default (as defined) occurs, the
       noteholders may declare the unpaid principal and interest due and payable
       immediately. If the Company defaults with respect to payment of interest,
       the Company will be required to pay interest at a default rate equal to
       12%.

       In addition, in connection with the issuance of the 8% Convertible Notes,
       the Lender (see Note 6) received a warrant to purchase 2,750,000 shares
       of common stock at $.60 per share. The warrant was granted as
       consideration to the Lender for relinquishing to holders of the 8%
       Convertible Notes seniority upon liquidation of the Company. The Company
       computed the value of the warrant to be $547,328, using the Black-Scholes
       option-pricing model. The Company has recorded the $547,328 as a deferred
       financing cost, which will be amortized to interest expense over the term
       of the 8% Convertible Notes.

                                       7

<PAGE>

(8)    $2.0 MILLION LINE OF CREDIT

       On May 30, 2000, the Company entered into a Line of Credit Agreement
       pursuant to which the LOC Lenders agreed to provide the Company with the
       Line of Credit (see Note 1). The Line of Credit is intended to provide
       the Company with working capital pending the closing of the Asset Sale.
       The Company may draw upon the facility by notice at any time prior to the
       earlier of September 30, 2000, and the date the Asset Sale is
       consummated. The Company may specify a draw date of not earlier than
       seven business days following the notice. Each draw is subject to
       conditions that are standard for similar transactions of this sort,
       including the absence of defaults, the absence of material adverse
       changes and the continued effectiveness of the agreement providing for
       the Asset Sale. On July 10, 2000, the Company drew down approximately
       $0.5 million under the Line of Credit Agreement.

       Amounts drawn down under the Line of Credit will mature and become due
       and payable on the earlier of September 30, 2000, and the date the Asset
       Sale is consummated. At the maturity date, each LOC Lender may elect
       either (a) to convert its portion of the amount outstanding under the LOC
       into shares of common stock at the rate of one share for each $1.08 of
       principal and interest then accrued (the $1.08 conversion price being
       equal to the closing price of the common stock at the time the LOC
       Lenders agreed to enter into the Line of Credit Agreement) or (b) to have
       the Company repay in cash the amount outstanding under the LOC.

       The LOC Lenders, the holders of the 8% Convertible Notes (Note 7), and
       the Lender (Note 6) on July 10, 2000 entered into an amendment (the
       Amendment) to the Subordination and Intercreditor Agreement between the
       Company, the holders of the 8% Convertible Notes, and the Lender. That
       agreement, entered into December 7, 1999, provided that the successors to
       the $6.0 million loan would subordinate their rights to payment and their
       security interest in the collateral (consisting of substantially all of
       the Company's assets) to those of holders of the 8% Convertible Notes.
       The Amendment provides that the LOC Lenders will have rights to payment
       and interest in the collateral which are equal with those of the holders
       of the 8% Notes and senior to the rights of the Lenders.

       In the Amendment all parties to the Subordination and Intercreditor
       Agreement agree to release their lien on the portion of the collateral
       that includes assets to be conveyed in the Asset Sale. In return for this
       partial release, the Company undertook in the Amendment that upon
       consummation of the Asset Sale it would set aside from the proceeds
       thereof the sum of $5.0 million with which it will purchase a money
       market instrument and pledge the same as collateral to secure its
       obligations to the LOC Lenders, the holders of the 8% Convertible Notes
       and the Lenders. The amount of the pledge will be reduced as the debt is
       converted to equity or repaid. The lenders that are party to the
       Subordination and Intercreditor Agreement, as amended, will continue to
       have a lien on substantially all of the Company's assets remaining after
       the Asset Sale.

       In connection with the Line of Credit, the Company has agreed (a) to
       issue to the representatives of the LOC Lenders warrants to purchase up
       to 500,000 shares of common stock at an exercise price of $1.08 per share
       and (b) to issue to the LOC Lenders, proportionate to their respective
       interests in the Line of Credit, warrants to purchase 1,000,000 shares of
       common stock at an exercise price of $1.08 per share. The Company
       computed the value of the warrants to be $731,136, using the
       Black-Scholes option-pricing model. The Company will amortize this amount
       to interest expense over the term of the Line of Credit.

                                       8

<PAGE>

(9)    ASSET PURCHASE AGREEMENT

       On June 29, 2000, the Company entered into an Asset Purchase Agreement to
       sell the assets of its Hybridon Specialty Products business, which
       manufactures, markets, and sells oligonucleotides. The Company expects to
       record a gain on the Asset Sale at the time of closing, composed of net
       proceeds of $12.0 million, less estimated transaction and other costs and
       net assets sold. The remaining $3.0 million, subject to offset, will be
       recorded as a gain on the Asset Sale after it is earned. This gain will
       be recognized when it is realized on the closing date of the Asset Sale
       which is expected to take place by the end of September 2000. The
       transaction costs consist principally of legal and accounting fees,
       severance arrangements with certain employees, and other estimated costs
       associated with consummating the sale. Closing is subject to various
       conditions, including the approval of the holders of 75% of the common
       and preferred stock, and of 100% of the debt holders. A special meeting
       of shareholders is scheduled for September 12, 2000.

       At the closing, the Company will receive $12.0 million of the proceeds,
       less an approximately $450,000 reserve, which will be held for 30 days as
       security for the value of the purchased inventory and against prepayments
       for uncompleted work received by the Company in advance of the sale. One
       year later, subject to certain conditions, the Company will receive an
       additional $3 million. The conditions to the second payment include the
       Company 's compliance with material purchases under a supply agreement
       that requires it to buy certain amounts of oligonucleotides from Boston
       Biosystems, Inc., the buyer in the Asset Sale.

       The net assets as of June 30, 2000 included in the sale consist of the
       following :

       Property and equipment, net                   $  5,336,000
       Security deposit                                    90,000
                                                     ------------
       Total assets                                  $  5,426,000
       Current liabilities                              (  86,000)
       Long term liabilities                             (348,000)
                                                     ------------
                                                     $  4,992,000
                                                     ============


       The Company plans to use the proceeds of the Asset Sale for current
       operating expenses, including payment of certain current liabilities.


                                       9

<PAGE>


ITEM 2.   MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND
          RESULTS OF OPERATIONS

GENERAL

         Hybridon is involved in the discovery and development of genetic
medicines based on antisense technology. Hybridon began operations in February
1990 and since that time has been involved primarily in research and development
efforts, developing its manufacturing capabilities, and raising capital. In
order to commercialize its therapeutic products, Hybridon will need to address a
number of technological challenges and comply with comprehensive regulatory
requirements. All revenues received by Hybridon to date have been from
collaborative agreements, interest on invested funds and revenues from the
custom contract manufacturing of synthetic DNA and reagent products by its
manufacturing business, Hybridon Specialty Products ("HSP").

         Hybridon has incurred total losses of approximately $260.0 million
through June 30, 2000. Hybridon expects that its research and development and
general and administrative expenses will be significant in 2000 and future years
as it pursues its core drug development programs and expects to continue to
incur operating losses and significant capital needs beyond its internally
generated funds.

         Hybridon has entered into an Asset Purchase Agreement to sell the
assets of its Hybridon Specialty Products business to Boston Biosystems, Inc., a
Delaware corporation that is a wholly owned subsidiary of Avecia, Inc., for an
amount up to $15.0 million (that sale, the "Asset Sale"). Although an Asset
Purchase Agreement has been signed by the parties, the sale is subject to
approval by Hybridon's common and preferred shareholders. The Asset Purchase
Agreement requires the approval of 75% of the common and preferred stock, and of
100% of the debt holders. A shareholder meeting is scheduled for September 12,
2000 for the shareholders to vote on the transaction. Even if the transaction
receives shareholder approval, the purchase price will still be subject to
adjustment based on the amount of the inventory included in the sale and certain
payments received in respect of the business before the closing. At the closing,
Hybridon will receive $12.0 million of the proceeds, less an approximately
$450,000 reserve, which will be held for 30 days as security for the value of
the purchased inventory and against prepayments for uncompleted work received by
Hybridon in advance of the sale. One year later, subject to certain conditions,
Hybridon will receive an additional $3 million, subject to offset rights granted
to Boston Biosystems. The conditions to the second payment include Hybridon 's
performance under a supply agreement that requires it to buy certain amounts of
oligonucleotides.

         On May 30, 2000, Hybridon entered into a Line of Credit Agreement with
certain lenders who provided Hybridon with an 8%, $2.0 million credit facility
which is intended to provide Hybridon with working capital pending the closing
of the Asset Sale. On July 10, 2000, Hybridon drew down approximately $0.5
million under the Line of Credit Agreement.

         Hybridon's existing cash resources, including the $2.0 million line of
credit, are expected to be sufficient to fund operations into the fourth quarter
of 2000. Hybridon expects the Asset Sale to be completed by the end of September
2000. However, Hybridon can give no assurances that the Asset Sale will be
completed, given the conditions it is subject to, and, even on completion of the
sale, payment of a portion of the purchase price is subject to the reserve and
the right of offset. If the Asset sale is not completed, Hybridon's existing
cash resources and the Line of Credit may not be sufficient to fund its
operations and permit Hybridon to avoid a default under one or more of its
outstanding debt obligations. Hybridon's ability to continue operations would
then depend on the willingness of its obligors to waive any such default and on
its success in obtaining new funding from future sales of equity securities,
debt financings, and research and development collaborations.

                                       10

<PAGE>

         As of August 4, 2000, Hybridon had 38 full-time employees. Upon the
closing of the Asset Sale, Hybridon estimates it will have approximately 13
full-time employees.

         The financial statements of Hybridon have been restated to reflect the
financial results of the Hybridon Specialty Products business as a discontinued
operation for the periods ended June 30, 2000 and 1999, and December 31, 1999.

RESULTS OF OPERATIONS

THREE AND SIX MONTHS ENDED JUNE 30, 2000 AND 1999

         Hybridon had total revenues of $40,293 and $0.3 million for the three
months ended June 30, 2000 and 1999, respectively, and had total revenues of
$0.2 million and $0.6 million for the six months ended June 30, 2000 and 1999,
respectively.

         Receipt of service revenues from MethylGene, Inc. and OriGenix
Technologies, Inc., entities in which Hybridon has an equity interest, were zero
and $0.1 million for the three months ended June 30, 2000 and 1999,
respectively, and zero and $0.2 million for the six months ended June 30, 2000
and 1999, respectively. This decrease represents a decrease in support services
provided to these entities by Hybridon.

         Revenues from research and development collaborations were zero and
$0.2 million for the three months ended June 30, 2000 and 1999, respectively,
and $45,000 and $0.3 million for the six months ended June 30, 2000 and 1999,
respectively. This decrease was primarily due to the termination by Searle of
its collaboration agreement with Hybridon.

         Hybridon's research and development expenses were $0.9 million and $1.0
million for the three months ended June 30, 2000 and 1999, respectively, and
$2.0 million and $2.4 million for the six months ended June 30, 2000 and 1999,
respectively. This decrease reflects Hybridon's lower levels of cash available
for expenditures in 2000. Research and development salaries and related costs
remained at approximately the same level in 2000 as 1999. Hybridon's patent
expenses remained at approximately the same level in 2000 as 1999.

         Hybridon's general and administrative expenses were $0.9 million for
both the three months ended June 30, 2000 and 1999, and $1.8 million and $2.1
million for the six months ended June 30, 2000 and 1999, respectively. The
decrease for the six-month period reflects Hybridon's lower levels of cash
available for expenditures in 2000. General and administrative expenses related
to business development and public relations remained at approximately the same
level in 2000 as 1999, as did legal and accounting expenses.

         Hybridon's interest expense was $0.6 million and $0.2 million for the
three months ended June 30, 2000 and 1999, respectively, and $0.9 million and
$0.3 million for the six months ended June 30, 2000 and 1999, respectively. This
increase is attributable to the issuance of the 8% convertible subordinated
notes in December 1999.

         As a result of the above factors, Hybridon incurred net losses from
continuing operations of $2.3 million and $1.9 million for the three months
ended June 30, 2000 and 1999, respectively, and $4.6 million and $4.2 million
for the six months ended June 30, 2000 and 1999, respectively. Hybridon incurred
net losses from discontinued operations of $0.2 million and $0.8 million for the
three months ended June 30, 2000 and 1999, respectively, and $0.6 million and
$1.4 million for the six months ended June 30, 2000 and 1999, respectively.
Hybridon recorded preferred stock dividends on the Series A convertible
preferred stock of $1.0 million and $1.1 million for the three months ended June
30, 2000 and

                                       11

<PAGE>

1999, respectively, and $2.1 million for both the six months ended June 30, 2000
and 1999, respectively, resulting in a net loss applicable to common
stockholders of $3.5 million and $3.7 million for the three months ended June
30, 2000 and 1999, respectively, and $7.2 million and $7.7 million for the six
months ended June 30, 2000 and 1999, respectively.

LIQUIDITY AND CAPITAL RESOURCES

         During the six months ended June 30, 2000, Hybridon utilized
approximately $4.2 million to fund continuing operating activities and did not
incur any capital expenditures. For the same period, discontinued operations
required $0.5 million to fund discontinued activities. The primary use of cash
for operating activities was to fund Hybridon's loss of $4.6 million. Hybridon
expects to purchase a minimal amount of capital equipment in 2000 as part of its
effort to conserve cash resources.

         Hybridon had cash and cash equivalents of $0.3 million at June 30,
2000. However, since that date, Hybridon has spent a portion of such cash
resources and continues to have substantial obligations to lenders, real estate
landlords, trade creditors and others. On August 4, 2000, Hybridon's obligations
included $1.3 million principal amount of 9% notes, a $6.0 million loan from
Forum Capital Markets, LLC and others (collectively, the "Lender"),
approximately $7.7 million in 8% convertible notes and accrued interest as
described below, approximately $0.5 million from the Line of Credit as described
below, and approximately $0.9 million of accounts payable. Because of Hybridon's
financial condition, many trade creditors are only willing to provide Hybridon
with products and services on a cash-on-delivery basis. The loan agreement
covering the $6.0 million loan from Forum Capital Markets and others contains
certain financial covenants that require Hybridon to maintain minimum tangible
net worth and minimum liquidity requirements. The Lender has granted Hybridon a
waiver of compliance with the minimum tangible net worth and the minimum
liquidity requirements at June 30, 2000, and have agreed not to require that
Hybridon comply with those requirements for any periods commencing July 1, 2000
through September 30, 2000.

         On June 29, 2000, Hybridon announced that it and Avecia Limited
("Avecia"), one of Europe's leading specialty chemicals companies, have agreed
that Avecia, through its subsidiary, Boston Biosystems, Inc., will acquire the
oligonucleotide manufacturing business and related intellectual property of
Hybridon Specialty Products business for US $15.0 million, of which $12.0
million is payable at closing and $3.0 million is payable after one year,
subject to offset rights under the contract (that acquisition, the "Asset
Sale"). Avecia and Hybridon have also agreed that through 2002 Avecia will
supply oligonucleotides for Hybridon and its associated operations. Hybridon
will be required to purchase certain amounts of oligonucleotides from Avecia
until approximately the end of 2002. The Asset Sale, which requires Hybridon
shareholder approval and is subject to other conditions, is expected to be
completed by the end of September 2000.

         On May 30, 2000, Hybridon entered into a Line of Credit Agreement
pursuant to which certain lenders (the "LOC Lenders") agreed to provide Hybridon
with an 8%, $2.0 million credit facility (the "Line of Credit" or "LOC"). The
Line of Credit is intended to provide Hybridon with working capital pending the
closing of the Asset Sale. Hybridon may draw upon the Line of Credit by notice
at any time prior to the earlier of September 30, 2000, and the date the Asset
Sale is consummated. Hybridon may specify a draw date of not earlier than seven
business days following the notice. Each draw is subject to conditions that are
standard for transactions of this sort, including the absence of defaults, the
absence of material adverse changes and the continued effectiveness of the
agreement providing for the Asset Sale. On July 10, 2000, Hybridon drew down
approximately $0.5 million under the Line of Credit.

                                       12

<PAGE>

         Amounts drawn down under the Line of Credit will mature and become due
and payable on the earlier of September 30, 2000, and the date the Asset Sale is
consummated. At the maturity date, each LOC Lender may elect either (a) to
convert its portion of the amount outstanding under the LOC into shares of
Hybridon's common stock at the rate of one share for each $1.08 of principal and
interest then accrued (the $1.08 conversion price being equal to the closing
price of Hybridon's common stock at the time the LOC Lenders expressed their
willingness to enter into the Line of Credit Agreement) or (b) to have Hybridon
repay in cash the amount outstanding under the LOC.

         The LOC Lenders have joined with the holders of Hybridon's 8%
Convertible Notes issued in 1999 and the Lender in a July 10, 2000 amendment
(the "Amendment") to the Subordination and Intercreditor Agreement Hybridon, the
8% Convertible Noteholders, and the Lender were parties. That agreement, entered
into December 7, 1999, provided that the successors to the $6.0 million loan
would subordinate their rights to payment and their security interest in the
collateral (consisting of substantially all of Hybridon's assets) to those of
the 8% Convertible Noteholders. The Amendment provides that the LOC Lenders will
have rights to payment and interest in the collateral which are equal with those
of the 8% Convertible Noteholders and senior to the rights of the Lender.

         In the Amendment all parties to the Subordination and Intercreditor
Agreement agree to release their lien on the portion of the collateral that
includes assets to be conveyed in the Asset Sale. In return for this partial
release, Hybridon undertook in the Amendment that upon consummation of the Asset
Sale it would set aside from the proceeds thereof the sum of $5.0 million with
which it will purchase a money market instrument and pledge the same as
collateral to secure its obligations to the LOC Lenders, the 8% Convertible
Noteholders and the Lender. The amount of the pledge will be reduced as the debt
is converted to equity. The lenders that are party to the Subordination and
Intercreditor Agreement, as amended, will continue to have a lien on
substantially all of the assets of Hybridon remaining after the Asset Sale.

         In connection with the Line of Credit, Hybridon has agreed (a) to issue
to the representatives of the LOC Lenders warrants to purchase up to 500,000
shares of Hybridon's common stock at an exercise price of $1.08 per share and
(b) to issue to the LOC Lenders, proportionate to their respective interests in
the Letter of Credit, warrants to purchase 1,000,000 shares of Hybridon's common
stock at an exercise price of $1.08 per share.

HISTORY OF OPERATING LOSSES; UNCERTAINTY OF FUTURE PROFITABILITY

         Since inception, Hybridon has incurred significant losses, which it has
funded through the issuance of equity securities, debt issuances, sales by HSP,
and through research and development collaborations and licensing arrangements.

FUTURE CAPITAL NEEDS; UNCERTAINTY OF ADDITIONAL FUNDING

The Asset Sale

         The purchase price in the Asset Sale is payable in two parts: $12.0
million at closing (of which the Purchaser will retain $450,000 for 30 days as
security for the value of the purchased inventory and against prepayments for
uncompleted work received by Hybridon in advance of the Asset Sale, and $3.0
million, payable one year from the date of closing. Receipt of the additional
$3.0 million payment one year from the date of closing is subject to additional
conditions, notably Hybridon's purchase of certain quantities of product from
Boston Biosystems under a supply agreement, and is also subject to offset rights
granted to Boston Biosystems.

                                       13

<PAGE>

         There can be no assurance that the Asset Sale can be completed, as the
closing is subject to conditions, including the approval of the transaction by
holders of at least 75% of Hybridon's common and preferred Stock. Hybridon's
existing cash resources, including the Line of Credit, are expected to be
sufficient to fund operations through Hybridon's receipt of proceeds of the
Asset Sale (see "Liquidity and Capital Resources") and into the fourth quarter
of 2000. The Asset Sale is expected to be completed by the end of September
2000. If the Asset Sale is not completed, Hybridon's existing cash resources and
the Line of Credit may not be sufficient to fund its operations and permit
Hybridon to avoid a default under one or more of its outstanding debt
obligations. Hybridon's ability to continue operations would then depend on the
willingness of its obligors to waive any such default and on its success in
obtaining new funding.

         Hybridon expects that the first installment of the proceeds from the
Asset Sale, in the amount of $12 million, should enable it to operate into the
third quarter of 2001, at which time it expects to collect the second
installment of the proceeds from the Asset Sale in the amount of $3.0 million,
which should enable it to sustain its operations through the year 2001, assuming
that Avecia claims no offset pursuant to offset rights granted it. Hybridon will
generate a gain on the transaction, and upon closing and receipt of the first
installment of the purchase price, Hybridon will have $5.0 million of restricted
cash that will be available to fund its operations. Even though Hybridon expects
to have sufficient cash to fund its operations through 2001, it will be required
to raise substantial additional funds from external sources to support its
operations in 2002 and beyond.

         Assuming the completion of the Asset Sale, Hybridon's future capital
requirements will depend on many factors, including the following:

       o      whether or not it receives the contingent Asset Sale consideration

       o      continued scientific progress in its research

       o      whether or not its drug discovery and development programs succeed

       o      progress with preclinical and clinical trials

       o      the time and costs involved in obtaining regulatory approvals

       o      the costs involved in filing, prosecuting and enforcing patent
              claims

       o      competing technological and market developments

       o      establishing and maintaining collaborative academic and commercial
              research, development and marketing relationships

       o      its ability to obtain third-party financing for leasehold
              improvements and other capital expenditures

       o      the costs of manufacturing scale-up and commercialization
              activities and arrangements

SAFE HARBOR FOR FORWARD-LOOKING STATEMENTS

         The statements contained in this Report on Form 10-Q that are not
historical are forward-looking statements within the meaning of Section 27A of
the Securities Act of 1933, as amended, and Section 21E of the Securities
Exchange Act of 1934, as amended, including statements regarding the
expectations, beliefs, intentions or strategies regarding the future. Hybridon
intends that all forward-looking statements be subject to the safe harbor
provisions of the Private Securities Litigation Reform Act of 1995. These
forward-looking statements reflect Hybridon's views as of the date they are made
with respect to future events and financial performance, but are subject to many
risks and uncertainties, which could cause actual results to differ materially
from any future results expressed or implied by such forward-looking


                                       14

<PAGE>

statements. Examples of such risks and uncertainties include the risks detailed
above and in the Risk Factors section of Hybridon's Annual Report on Form 10-K
for the year ended December 31, 1999, which information is incorporated herein
by reference.


                                       15

<PAGE>


                                 HYBRIDON, INC.

                                     PART II

                                OTHER INFORMATION


ITEM 1.  LEGAL PROCEEDINGS

         None.

ITEM 2.  CHANGES IN SECURITIES AND USE OF PROCEEDS

         None.

ITEM 3.  DEFAULTS UPON SENIOR SECURITIES

         None.

ITEM 4.  SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

         At Hybridon's Annual Meeting of Stockholders held on June 29, 2000, the
stockholders elected the following three individuals as Class II Directors to
hold office until the 2003 Annual Meeting of Stockholders:

                                        For                Against       Abstain
                                        ---                -------       -------

         Camille A. Chebeir             13,060,167         364,703          0

         James B. Wyngaarden, M.D.      13,058,467         366,403          0

         Paul C. Zamecnik, M.D.         13,059,667         365,203          0


         The term of office as a director for each of the following individuals
continued after the meeting:

         Arthur W. Berry

         C. Keith Hartley

         Nasser Menhall

         Sudhir Agrawal, D.Phil.

         Youssef El-Zein

         E. Andrews Grinstead, III

         The stockholders also approved a proposal to amend Hybridon's 1997
Stock Incentive Plan. The holders of 9,016,979 shares of common stock voted for
the proposal; the holders of 472,306 shares of common stock voted against the
proposal; the holders of 235,590 shares of common stock abstained from voting;
and the holders of 7,769,208 shares of common stock were broker non-votes.

         Finally, the stockholders ratified the selection of Arthur Andersen LLP
as the independent public accountants to audit Hybridon's consolidated financial
statements. The holders of 13,191,370 shares of

                                       16

<PAGE>

common stock voted for the ratification; the holders of 4,200 shares of common
stock voted against; the holders of 229,250 shares of common stock abstained
from voting; and the holders of 4,069,213 shares of common stock were broker
non-votes.


ITEM 5.  OTHER INFORMATION

         None.


ITEM 6.  EXHIBITS AND REPORTS ON FORM 8-K

(a)      Exhibits

         10.1       Line of Credit Security Agreement dated as of May 30, 2000,
                    between Hydridon and certain lenders (filed herewith).

         10.2       First Amendment and Restated Subordination and Intercreditor
                    Agreement between Hybridon, holders of its 8% Convertible
                    Notes, and certain other lenders (filed herewith).

         27.1       Financial Data Schedule (EDGAR) (filed herewith)

(b)      Reports on Form 8-K

         On June 29, 2000, Hybridon filed a Current Report on Form 8-K,
         reporting that Hybridon and Avecia Limited, one of Europe's leading
         specialty chemicals companies, have agreed on terms for Avecia to
         acquire the DNA manufacturing business and related intellectual
         property of Hybridon.


                                       17

<PAGE>

                                   SIGNATURES


         Pursuant to the requirements of the Securities Exchange Act of 1934, as
amended, the registrant has duly caused this report to be signed on its behalf
by the undersigned thereunto duly authorized.

                                          HYBRIDON, INC.



                                          /s/ Sudhir Agrawal
Date:  August 14, 2000                    -------------------------------------
                                          Sudhir Agrawal, D. Phil.
                                          President and Acting Chief Executive
                                          Officer


                                          /s/ Robert G. Andersen
Date:  August 14, 2000                    -------------------------------------
                                          Robert G. Andersen
                                          Chief Financial Officer and Vice
                                          President of Operations and Planning


                                       18




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