VIMRX PHARMACEUTICALS INC
DEF 14A, 1997-06-23
PHARMACEUTICAL PREPARATIONS
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                                  May 21, 1997


Dear Stockholder:

         You are cordially  invited to attend the Annual Meeting of Stockholders
of VIMRX  Pharmaceuticals  Inc., which will be held at The Equitable  Companies,
Inc., 787 Seventh Avenue,  49th Floor,  New York, New York on June 24, 1997. The
meeting will begin promptly at 9:30 a.m. Eastern Daylight Time.

         The  accompanying  Proxy  Statement,   which  you  are  urged  to  read
carefully,  provides  important  information  regarding  matters  that  will  be
considered  and voted  upon at the  Annual  Meeting.  In  addition  to  electing
directors  of the Company  and  ratifying  the  appointment  of the  independent
auditors,  stockholders  will  consider  and  vote  upon (i)  approving  certain
amendments to VIMRX's 1990  Incentive and  Non-Incentive  Stock Option Plan (the
"1990 Plan  Amendments") to conform the Plan to certain statutory and regulatory
developments  and to  provide  the  Board  of  Directors  and  the  Compensation
Committee with greater  flexibility  in determining  the terms and conditions of
options,  and  (ii)  approving  the  adoption  of  VIMRX's  1997  Incentive  and
Non-Incentive  Stock  Option Plan (the "1997 Plan")  providing  for the award of
options to purchase 1,000,000 shares of Common Stock.

         The 1990 Plan  Amendments  and the 1997 Plan will assist the Company in
attracting  persons of  outstanding  ability to its service.  The 1990 Plan,  as
amended,  and  the  1997  Plan  (collectively,   the  "Plans")  provide  greater
flexibility to the Company in  administering  the Plans than was available under
the 1990 Plan prior to the amendments.

         You are  requested to complete,  date and sign the enclosed  proxy card
and  promptly  return it in the  enclosed  envelope,  whether or not you plan to
attend the Annual Meeting. If you do attend the Annual Meeting,  you may vote in
person  even if you have  submitted  a proxy  card.  Due to  space  limitations,
attendance  at the Annual  Meeting  will be limited to  stockholders  of record,
their  proxies,  beneficial  owners of Common  Stock who have  presented  to the
Company  satisfactory  evidence of such ownership and brokers.  Proper  business
attire is required.

         On behalf of the Board of  Directors,  I look  forward to seeing you on
June 24th.

                                   Sincerely,



                                Donald G. Drapkin
                                    Chairman


<PAGE>






                           VIMRX PHARMACEUTICALS INC.
                              2751 Centerville Road
                           Suite 210, Little Falls II
                           Wilmington, Delaware 19808
                                 (302) 998-1734

                    NOTICE OF ANNUAL MEETING OF  STOCKHOLDERS To Be Held on June
                           24, 1997

To the Stockholders of VIMRX PHARMACEUTICALS INC.

                  NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders
("Annual Meeting") of VIMRX Pharmaceuticals Inc. (the "Company") will be held at
The Equitable  Companies,  Inc., 787 Seventh Avenue,  49th Floor,  New York, New
York on Tuesday,  June 24, 1997 at 9:30 a.m., Eastern Daylight Time, to consider
and act upon the following proposals:

                  1.       To elect a Board of eight directors.

                  2.       To approve  amendments to the Company's  1990
                           Incentive and Non-Incentive Stock Option Plan.

                  3.       To  approve  the   Company's   1997   Incentive   and
                           Non-Incentive  Stock  Option Plan  providing  for the
                           award of  options  to  purchase  1,000,000  shares of
                           Common Stock thereunder.

                  4.       To ratify the  appointment  of KPMG Peat  Marwick LLP
                           as  independent  auditors  of   the  Company for the
                           year ending December 31, 1997.

                  5.       To transact such other  business as  may   properly
                           come before the Annual  Meeting or any   adjournment
                           or postponement thereof.

                  A proxy  statement  describing the matters to be considered at
the Annual  Meeting is attached to this  notice.  Only  holders of record of the
Company's  Common Stock at the close of business on May 2, 1997, the Record Date
for the  Annual  Meeting,  are  entitled  to notice of and to vote at the Annual
Meeting.  Due to space  limitations,  attendance  at the Annual  Meeting will be
limited to stockholders  of record,  their proxies,  beneficial  owners who have
presented evidence of such ownership satisfactory to the Company, and brokers.
Proper business attire is required.

                       By Order of the Board of Directors,

                                                     Lowell S. Lifschultz
                                    Secretary
Wilmington, Delaware
May 21, 1997

           STOCKHOLDERS WHO DO NOT EXPECT TO ATTEND THE ANNUAL MEETING
          ARE REQUESTED TO DATE, SIGN AND PROMPTLY RETURN THE ENCLOSED
                 PROXY IN THE ENCLOSED POSTAGE-PREPAID ENVELOPE.


<PAGE>




                           VIMRX Pharmaceuticals Inc.
                              2751 Centerville Road
                           Suite 210, Little Falls II
                           Wilmington, Delaware 19808
                                 (302) 998-1734



                                 PROXY STATEMENT


                         Annual Meeting of Stockholders
                           To Be Held On June 24, 1997


                                  INTRODUCTION

General

         This Proxy Statement is being furnished to holders of Common Stock, par
value $.001 per share (the "Common  Stock"),  of VIMRX  Pharmaceuticals  Inc., a
Delaware  corporation  (the  "Company"),  in connection with the solicitation of
proxies by the Board of Directors  of the Company for use at its Annual  Meeting
of  Stockholders  to be  held  on  Tuesday,  June  24,  1997,  at The  Equitable
Companies,  Inc., 787 Seventh Avenue, 49th Floor, New York, New York on Tuesday,
June 24, 1997 at 9:30 a.m.,  Eastern Daylight Time, and any and all adjournments
or postponements  thereof (the "Meeting").  The cost of the solicitation will be
borne by the Company.  This Proxy  Statement is being first mailed to holders of
the Common Stock on or about May 21, 1997.

Matters to be Considered at the Meeting

         At the  Meeting,  the  stockholders  will be asked to consider and vote
upon the following proposals:



<PAGE>



         1.       To elect a Board of eight directors;


         2.       To approve certain  amendments (the "1990 Plan Amendments") to
                  the Company's  1990 Incentive and  Non-Incentive  Stock Option
                  Plan (the  "1990  Plan") to  conform  the 1990 Plan to certain
                  statutory and regulatory developments and to provide the Board
                  of  Directors  and the  Compensation  Committee  with  greater
                  flexibility  in  determining   the  terms  and  conditions  of
                  options; a copy of the 1990 plan is attached hereto as Exhibit
                  A;

         3.       To approve the 1997 Stock Option Plan (the "1997  Plan"),
                  providing for the award of options to purchase 1,000,000
                  shares of Common Stock thereunder;

         4.       To ratify the  appointment  of KPMG Peat Marwick LLP as
                  independent  auditors of the Company for the year ending
                  December 31, 1997; and

         5.       To  transact  such  other  business  as may  properly  come
                  before  the  Annual  Meeting  or any adjournment or
                  postponement thereof.


Voting at the Meeting



<PAGE>



         Only  holders of record of Common Stock at the close of business on May
9,  1997  (the  "Record  Date")  are  entitled  to  notice of and to vote at the
Meeting,  each such  holder of record  being  entitled  to one vote per share of
Common Stock on each matter to be considered at the Meeting. On the Record Date,
there were 54,642,437 shares of Common Stock issued and outstanding.


         The presence,  in person or by properly  executed proxy, of the holders
of a majority of the outstanding  shares of Common Stock entitled to vote at the
Meeting (27,321,219 shares of the 54,642,437 shares outstanding) is necessary to
constitute a quorum at the Meeting.  The election of each of the eight  nominees
identified in this Proxy will require the affirmative vote of a plurality of the
shares of Common Stock present in person or  represented by proxy at the Meeting
and entitled to vote. The approval of the 1990 Plan Amendments and the 1997 Plan
and the  ratification of the appointment of KPMG Peat Marwick LLP as independent
auditors of the Company for the year ending  December  31, 1997 will require the
affirmative  vote of the  holders  of a majority  of the shares of Common  Stock
present in person or represented by proxy at the Meeting and entitled to vote.

         If the  enclosed  proxy card is properly  executed  and returned to the
Company prior to voting at the Meeting,  the shares represented  thereby will be
voted in  accordance  with  the  instructions  marked  thereon,  subject  to the
following conditions:

         Election of Directors.  Shares  represented  by a proxy which is marked
"WITHHOLD  AUTHORITY" to vote for (i) all eight  nominees or (ii) any individual
nominee(s)  for election as  directors  and are not  otherwise  marked "FOR" the
other nominees will not be counted in  determining  whether a plurality vote has
been  received for the election of  directors.  In the absence of  instructions,
shares  represented by a proxy will be voted FOR all of the eight  nominees.  In
instances where brokers are prohibited from exercising  discretionary  authority
for beneficial owners who have not returned proxies ("broker non-votes"),  those
shares will be  disregarded  and therefore will have no effect on the outcome of
the vote.

         Other  Proposals.  Shares  represented  by  a  proxy  which  is  marked
"ABSTAIN" on any other proposal will not be counted in  determining  whether the
requisite  vote  has  been  received  for  such  proposal.  In  the  absence  of
instructions,  shares  represented  by a  proxy  will  be  voted  FOR all of the
proposals set forth in the Notice of Annual Meeting and at the discretion of the
proxies on any other  matters  that may  properly  come before the  Meeting.  In
instances where brokers are prohibited from exercising  discretionary  authority
for beneficial owners who have not returned proxies ("broker non-votes"),  those
shares will not be  included  in the vote  totals,  and  therefore  will have no
effect on the vote for the  approval  of the 1990 Plan  Amendments  and the 1997
Plan or ratification of the appointment of the independent auditors.




         At any time prior to its exercise, a proxy may be revoked by the holder
of the Common Stock granting it by delivering  written notice of revocation or a
duly executed  proxy bearing a later date to the Secretary of the Company at the
address of the Company set forth on the first page of this Proxy Statement or by
attending the Meeting and voting in person.






                                       2
<PAGE>









Table of Contents
                                                                         Page
Security Ownership of Certain Beneficial
  Owners and Management..............................................      4
Election of Directors................................................      6
Executive Compensation ..............................................      8
Certain Transactions.................................................     13
Stock Price Performance Comparison...................................     15
Approval of Amendments to 1990 Incentive and
  Non-Incentive Stock Option Plan and 1997 Incentive
  and Non-Incentive Stock Option Plan ...............................     16
Ratification of Reappointment of Independent
  Auditors...........................................................     22
Other Business.......................................................     22
Stockholder Proposals................................................     23




                                       3
<PAGE>





         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT



         The following table sets forth, as of the Record Date, information with
respect to the beneficial ownership of the Common Stock by (i) each person known
by the  Company to own  beneficially  five  percent  or more of the  outstanding
Common Stock, together with their respective  addresses,  (ii) each director and
nominee for  election as director,  (iii) each  executive  officer  named in the
Summary Compensation Table under "Executive Compensation - Summary Compensation"
on page 9 of this Proxy Statement and (iv) all executive  officers and directors
as a group:
<TABLE>
<CAPTION>

                                                                 Shares                Percent
                        Name                               Beneficially Owned        Outstanding
<S>                                                        <C>                       <C>
Richard L. Dunning.................................                   257,256(1)          *

Francis M. O'Connell...............................                    50,000(2)          *
Alfonso, J. Tobia, Ph.D. ..........................                    75,000(2)          *
Donald G. Drapkin .................................                462,500(3)(4)          *
Laurence D. Fink ..................................                450,000(3)(5)          *
Jerome Groopman, M.D. .............................                    50,000(3)          *
Linda G. Robinson .................................                   183,333(3)          *
Eric A. Rose, M.D. ................................                   584,900(6)          *
Lindsay A. Rosenwald, M.D. ........................              6,114,999(3)(7)        10.8%
  787 Seventh Avenue
  New York, New York 10019
Michael Weiner, M.D. ..............................                    62,410(3)          *
Paramount Capital Asset
  Management, Inc..................................                 4,049,999(8)        7.4%
  c/o Lindsay A. Rosenwald, M.D.
  787 Seventh Avenue
  New York, New York 10019
Mellon Bank Corporation............................                 2,865,000(9)        5.2%
  One Mellon Bank Center
  Pittsburgh, Pennsylvania 15258
All directors and executive                                        8,311,737(10)        14.4%
  officers as a group (12) persons) ...............
</TABLE>

- --------------------

                                       4
<PAGE>

*        Less than one percent.

(1)      Consists of currently  exercisable  options to purchase  253,661 shares
         owned by Mr. Dunning,  2,095 shares owned by a daughter of Mr. Dunning,
         and 500 shares owned by each of Mr. Dunning's  spouse,  son and another
         daughter,  respectively.  Mr. Dunning disclaims beneficial ownership of
         the shares held by his spouse, son and daughters.

(2)      Consists of currently exercisable options.

(3)      Includes  100,000  shares for Mr. Drapkin and 50,000 shares for each of
         Mr. Fink, Dr. Groopman,  Ms. Robinson,  Dr. Rosenwald and Dr. Weiner of
         restricted  stock  which  vests at the rate of 25% per year  commencing
         June 20, 1997, provided the respective individual continues to serve as
         a director of the Company,  and subject to a non-lapsing right of first
         refusal by the Company.

(4)      Includes currently exercisable options to purchase 362,500 shares.

(5)      Includes  66,666  shares owned by a family trust for the benefit of Mr.
         Fink's children.  Mr. Fink disclaims beneficial ownership of the shares
         held by the family trust.

(6)      Includes currently exercisable options to purchase 262,500 shares.

(7)      Includes  currently  exercisable  options to purchase  2,015,000 shares
         owned by Dr. Rosenwald,  and the 4,049,999 shares beneficially owned by
         Paramount Capital Asset Management, Inc. ("PCAM") (see note (8) below).
         Dr.  Rosenwald serves as President and is sole shareholder of PCAM. Dr.
         Rosenwald  disclaims  beneficial  ownership of the shares  beneficially
         owned by PCAM.

(8)      Information  is from a Schedule  13D dated  December  23, 1996 filed by
         PCAM which is the  investment  manager of The Aries  Trust (the  "Aries
         Trust") and the  general  partner of Aries  Domestic  Fund,  L.P.  (the
         "Aries Limited Partnership"), and reports shared voting and dispositive
         power of 5,964,999 shares and 2,750,000  shares,  respectively,  by the
         Aries Trust and the Aries Limited Partnership.

(9)      Information  is from a Schedule 13G dated  January 24,  1997,  filed by
         Mellon Bank Corporation,  which reflects sole voting power with respect
         to  2,865,000  shares  and  sole  dispositive  power  with  respect  to
         2,750,000 shares.

(10)     See notes (1) - (7).




                                       5
<PAGE>




                              ELECTION OF DIRECTORS


         At the Meeting, the entire Board of Directors is to be elected, to hold
office until the next Annual Meeting of Stockholders  and until their successors
are duly  elected  and  qualified.  Unless  otherwise  specifically  directed by
stockholders  executing  proxies,  it  is  intended  that  all  proxies  in  the
accompanying  form  received  in time  for the  Meeting  will be  voted  FOR the
election of the eight nominees named below. All nominees are currently directors
of the Company.

         In the event any nominee should become unavailable for election for any
presently  unforeseen  reason, it is intended that the proxies will be voted for
such substitute nominee as may be designated by the present Board of Directors.

         The election of each of the eight nominees identified in the Proxy will
require the  affirmative  vote of a plurality vote of the shares of Common Stock
present  or  represented  by proxy  at the  Meeting  and  entitled  to vote.  In
instances where brokers are prohibited from exercising  discretionary  authority
for beneficial owners who have not returned proxies ("broker non-votes"),  those
shares will be  disregarded  and therefore will have no effect on the outcome of
the vote. The Board of Directors  recommends that  stockholders vote FOR each of
the eight nominees.

         Each nominee's  name,  age,  office with the Company,  if any, the year
first elected as a director,  if currently a director,  and certain biographical
information are set forth below:

Name                                    Age        Position
Donald G. Drapkin                        49        Chairman
Richard L. Dunning                       51    President, Chief
                                            Executive Officer and
                                                   Director
Laurence D. Fink                         44        Director
Jerome Groopman, M.D.                    45        Director
Linda G. Robinson                        44        Director
Eric A. Rose, M.D.                       46        Director
Lindsay A. Rosenwald, M.D.               42        Director
Michael Weiner, M.D.                     51        Director


         DONALD G. DRAPKIN was elected  Chairman of the Board in March 1996. Mr.
Drapkin has served as a director of the Company since  November 17, 1995.  Since
March 1987,  Mr.  Drapkin has been Vice  Chairman and a director of MacAndrews &
Forbes Holdings Inc., and was a partner in the law firm of Skadden, Arps, Slate,
Meagher  & Flom in New York City for more than five  years  prior  thereto.  Mr.
Drapkin  also  serves as a director  of the  following  corporations  which file
reports  pursuant to the Securities  Exchange Act of 1934 (the "Exchange  Act"):
Andrews Group,  Incorporated,  The Coleman Company, Inc., Coleman Holdings Inc.,
Coleman Worldwide Corporation, Marvel Entertainment Group, Inc., Marvel Holdings
Inc.,  Marvel (Parent)  Holdings Inc., Marvel III Holdings Inc., Revlon Consumer
Products Corporation, Revlon, Inc., Revlon Worldwide Corporation, Toy Biz, Inc.
and Algos Pharmaceutical Corporation.

                                       6
<PAGE>

         RICHARD L. DUNNING has been  President and Chief  Executive  Officer of
the Company since April 1996,  and a director of the Company  since June,  1996.
Prior to joining the Company, Mr. Dunning served as Executive Vice President and
Chief Financial Officer of the DuPont Merck  Pharmaceutical  Company since 1991.
Mr. Dunning also serves as a director of the following  corporations  which file
reports pursuant to the Securities Exchange Act of 1934: Epoch  Pharmaceuticals,
Inc. and Innovir Laboratories, Inc.

         LAURENCE  D. FINK has been  Chairman  and Chief  Executive  Officer and
Director of BlackRock Financial Management  (investment advisor) since 1988. Mr.
Fink is a  director  of the  closed  end  funds for  which  BlackRock  serves as
investment  advisor.  Mr. Fink has been a director  of the  Company  since June,
1996.  Mr.  Fink also serves as a director of the  following  corporation  which
files  reports  pursuant  to  the  Securities  Exchange  Act  of  1934:  Innovir
Laboratories, Inc.

         JEROME  GROOPMAN,  M.D.  has been a  professor  of  Medicine at Harvard
Medical  School since 1993.  Dr.  Groopman has been an attending  physician  and
member of the executive  committee of New England Deaconess Hospital since 1989.
Dr.  Groopman has been a director of the Company since June,  1996. Dr. Groopman
is director of the  following  corporations  which file reports  pursuant to the
Exchange Act: Advanced Tissue Sciences.

         LINDA G.  ROBINSON  has been  Chairman,  Chief  Executive  Officer  and
Partner of Robinson Lerer Montgomery  (strategic  communications)  for more than
the past five years. Ms. Robinson has been a director of the Company since June,
1996.  Ms.  Robinson  is a director  of the  following  corporations  which file
reports pursuant to the Exchange Act: Revlon, Inc.

         ERIC A. ROSE,  M.D.  was  elected a director of the Company on November
17, 1995. Dr. Rose is a Surgeon-In-Chief at Columbia Presbyterian Medical Center
in New York, a position he has held since August 1994, has served as Chairman of
the  Department of Surgery at the College of Physicians and Surgeons of Columbia
University  since  1994  and  prior  thereto  as  Director  of the  Division  of
Cardiothoracic  Surgery  of  the  Department  since  1990.  Dr.  Rose  is a past
president of the International Society for Heart and Lung Transplantation.

         LINDSAY A.  ROSENWALD,  M.D. has been the Chairman and Chief  Executive
Officer of Paramount  Capital,  Incorporated  (investment  bank) since 1992. Dr.
Rosenwald  is also  chairman  of The Castle  Group.  Dr.  Rosenwald  serves as a
director  of the  following  corporations  which file  reports  pursuant  to the
Exchange  Act:   Ansan,   Inc.,   Atlantic   Pharmaceuticals,   Inc.,   BioCryst
Pharmaceuticals,  Inc., Interneuron  Pharmaceuticals,  Inc., Neose Technologies,
Inc., Sparta Pharmaceuticals,  Inc., Titan Pharmaceuticals, Inc. and Xenometrix,
Inc. Dr. Rosenwald has been a director of the Company since June, 1996.

         MICHAEL  WEINER,  M.D.  has been the  Hellinger  Professor  of Clinical
Pediatrics  at Columbia  University  College of  Physicians  and Surgeons  since
January 1996 and has been an  attending  pediatrician  at Columbia  Presbyterian
Medical Center since January 1996.  Dr. Weiner has served as Associate  Director
of Pediatric Hematology/Oncology and Associate Attending Physician of Hackensack
Medical  Center  and an  Associate  Attending  Pediatrician  UMDNJ  Division  of
Pediatric Hematology/Oncology, since 1987. Dr. Weiner has been a director of the
Company since June, 1996.



                                       7
<PAGE>

Meetings and Committees



         During 1995,  there were seven meetings of the Board of Directors which
were attended by all directors, except for Mr. Donald G. Drapkin and Dr. Eric A.
Rose, who were absent from two meetings, and Dr. Jerome Groopman, who was absent
from one  meeting.  Additionally,  the Board took  action by  unanimous  written
consent without a meeting on five occasions in 1996.


         The  Compensation  Committee,  which  also  acts  as the  Stock  Option
Committee,  currently consists of Mr. Donald G. Drapkin, Mr. Richard L. Dunning,
Dr. Eric A. Rose and Dr. Lindsay A. Rosenwald.  The  Compensation  Committee met
one time and took action by unanimous  written  consent on one  occasion  during
1996.  The  Compensation  Committee  sets and  recommends  to the  Board  yearly
executive   compensation  and  conditions  of  employment  and  administers  the
Company's stock option plans.

         The Audit  Committee,  which  consists of Mr.  Richard L. Dunning,  Mr.
Laurence D. Fink,  Ms. Linda G. Robinson and Dr.  Michael  Weiner,  did not meet
during 1996. The Audit Committee  reviews the audit and financial  procedures of
the Company and  recommends  any changes  with  respect  thereto to the Board of
Directors.

         The Company does not have a standing nominating committee.


                             EXECUTIVE COMPENSATION

Summary Compensation

         The following table sets forth a summary of the  compensation for 1994,
1995 and 1996 earned by the Company's  Principal  Executive  Officer and by each
other executive officer whose compensation exceeded $100,000 during 1996.




                                       8
<PAGE>



<TABLE>
<CAPTION>


                           Summary Compensation Table
                                              Annual Compensation                Awards            Long-Term
                                                                                                  Compensation
              Name and               Year        Salary           Bonus         Options              Other
         Principal Position                                                                       Compensation
<S>                                  <C>        <C>            <C>            <C>               <C>
         ------------------                                                                       ------------
M.S. Koly                            1996                          --              $1,750(1)
  Former Chairman and Chief          1995             $37,000      --             200,000(3)              $4,003(1)
  Executive Officer(2)
                                     1994                  --      --                     --             $20,450(1)

Richard L. Dunning                   1996            $133,833    $40,000          800,000(3)              $4,500(4)
  President and Chief Executive      1995                  --      --                     --                     --
  Officer(5)
                                     1994                  --      --                     --                     --

Alfonso J. Tobia, Ph.D.              1996            $147,272    $50,000                  --                     --
Executive Vice President             1995            $130,000    $12,500                  --                     --
                                     1994             $59,696      --             150,000(6)             $25,000(7)

Francis M. O'Connell                 1996            $123,800    $35,000                  --                     --
Vice President, Finance and Chief    1995             $96,125      --             100,000(8)
Financial Officer
                                     1994
</TABLE>

- ---------------

 (1)   Consists of director fees in 1996 and 1995;  and $7,050 of director fees,
       $2,000 for consulting services, and $11,400 paid to Venkol Ventures, Ltd.
       for consulting  services rendered by Mr. Koly to the Company in 1994. Mr.
       Koly is a principal shareholder and advisor to Venkol Ventures, Ltd.

 (2)   Mr. Koly was Acting Chief Executive  Officer from September 1, 1995 until
       April 1996. Mr. Koly resigned as Chairman of the Board in March 1996.

 (3)   Number of shares of Common  Stock  purchasable.  See Option  Grant  Table
       below for exercise price and vesting terms.

                                       9
<PAGE>

 (4)   Reimbursement of personal medical and health care insurance.

 (5)   Mr. Dunning was elected  President and Chief Executive  Officer in April,
       1996.

 (6)   Number of shares of Common Stock purchasable at $.69 per share.

 (7)   Consists of a one-time relocation fee.

 (8)   Number of shares of Common Stock purchasable at $.44 per share.

         The nominees for director  have  received  grants of 50,000  restricted
shares of Common Stock under the 1996  Non-Employee  Director  Restricted  Stock
Award Plan,  except that Mr. Drapkin,  as Chairman,  received a grant of 100,000
shares, and Mr. Dunning, as an employee of the Company, received no grant.

Option Grant Table

         The following table sets forth certain  information  concerning options
granted in 1996 to the individuals named in the Summary Compensation Table:

                      Option Grants in the Last Fiscal Year
                      -------------------------------------

            Name           Number of     % of Total      Exercise     Expiration
                          Securities       Options       Price Per       Date
                         Underlying      Granted to        Share
                           Options     Employees in
                           Granted      Fiscal Year
                          ----------   -------------    ---------    -----------
Richard L. Dunning        800,000(1)       54.4           $2.56      4/2/2001(2)
                                                                     4/2/2006(2)

 (1)     Granted pursuant to Mr. Dunning's employment agreement. See "Employment
         Arrangements" below.

 (2)     Incentive stock options to purchase  156,064 shares expire on 4/2/2001;
         non-incentive stock options to purchase 643,946 shares expire 4/2/2006.


Mr.  Dunning was granted an Incentive  stock option to purchase  156,064  shares
under the  Company's  1990  Incentive and  Non-Incentive  Stock Option Plan (the
"1990 Plan"),  which at the time of issue provided that incentive  stock options
must have a five-year term. Mr. Dunning was also granted a  non-Incentive  stock
option to purchase  643,936 shares under the 1990 Plan;  pursuant to his amended
and restated employment agreement, the term of these options was extended to ten
years from the date of grant, and they became exercisable  cumulatively in three
substantially equal annual increments.





                                       10
<PAGE>




Option Exercise and Value Table

         The following table sets forth certain  information  concerning options
exercised during 1996, and the number of unexercised  options as at December 31,
1996 held, by the individuals named in the Summary Compensation Table:

                Option Exercises and Values at December 31, 1996
                ------------------------------------------------

<TABLE>
<CAPTION>
         Name                 Shares           Value          Number of            Value of
                             acquired         realized       Unexercised         Unexercised
                                on              (1)           Options at         In-the-Money
                             exercise                        December 31,         Options at
                                                                 1996            December 31,
                                                            Exercisable (E)/        1996(1)
                                                            Unexercisable
                                                                 (U)
                            ----------      ----------      -----------           ----------
<S>                         <C>             <C>              <C>                  <C>
M.S. Koly                      --              --             200,000(E)           $525,000
Richard L. Dunning                                            800,000(U)            $650,000
Alfonso J. Tobia, Ph.D.                                        75,000(E)            $201,375
                                                               75,000(U)            $201,375
Francis M. O'Connell                                           25,000(E)            $73,438
                                                               75,000(U)            $220,313
</TABLE>

 (1)     Based upon the $3 3/8 closing  price of the Common  Stock on The Nasdaq
         Stock Market on December 31, 1996.

Employment Arrangements

         In  October  1996,  the  Company  entered  into a  restated  employment
agreement with Richard L. Dunning,  effective March 27, 1996,  pursuant to which
Mr. Dunning serves as President and Chief Executive Officer of the Company.  The
agreement provides for a base annual salary of $200,000,  which may be increased
at the discretion of the Board of Directors or the Compensation  Committee,  and
an annual cash bonus based on performance  criteria,  with an initial cash bonus
targeted to be at least 33% of Mr. Dunning's base  compensation.  Mr. Dunning is
entitled to four weeks'  vacation and to participate  in the Company's  medical,
dental,  life and long-term  disability  insurance  and other benefit  programs.
Pursuant  to  the  agreement,   Mr.  Dunning  was  granted  both  incentive  and
non-incentive stock options to purchase an aggregate of 800,000 shares of Common
Stock at an exercise price of $2.56 per share,  the incentive  options  becoming
exercisable  cumulatively  at the rate of 25% per annum,  and the  non-incentive
options  becoming  exercisable  cumulatively  at the rate of 33-1/3%  per annum,
commencing  March 28,  1997 (one year from the date of grant).  Pursuant  to the
agreement, the expiration date of the incentive options is 4/2/2001, and that of
the  non-incentive  options  is  4/2/2006.   Mr.  Dunning's  employment  may  be
terminated  by the Company for cause,  or without  cause upon 60 days' notice by
either the Company or Mr.  Dunning.  In the event Mr.  Dunning's  employment  is
terminated by the Company without cause, or in the event Mr. Dunning  terminates
his employment  following  certain actions by the Company  (including a material
reduction in Mr.  Dunning's  duties or a relocation of the  Company's  principal
executive offices),  Mr. Dunning is entitled to a severance payment equal to six
months'  of his base  salary,  payable in monthly  installments.  The  agreement
contains certain  non-competition and confidentiality  provisions,  and provides
that the Company may obtain "key man" life  insurance on the life of Mr. Dunning
for the Company's  benefit.  Mr. Dunning  received a $40,000  signing bonus upon
execution of the agreement.

                                       11
<PAGE>

         In June 1994,  the Company  entered into an employment  agreement  with
Alfonso J.  Tobia,  Senior  (now,  Executive)  Vice  President  of the  Company,
effective  July 1, 1994,  providing for a base annual salary of $125,000,  to be
increased  to $150,000  upon the  redemption  by the Company of its  outstanding
Class A Warrants,  and eligibility for a discretionary bonus up to $25,000.  The
agreement  provides  that Dr.  Tobia is eligible to receive  options to purchase
150,000  shares of Common Stock (which were granted on August 24, 1994),  and is
eligible to  participate  in the Company's  benefit  programs,  which  currently
include a medical program, dental/vision insurance and group life insurance.

         M.S.  Koly,  former Chief  Executive  Officer of the Company and former
Chairman of the Board,  was paid $3,000 per month  commencing  June 1995 for his
services as  Chairman,  which  position  he held until March 1996,  and was paid
$7,000 per month for services as Acting Chief Executive Officer,  from September
1995 to April 1996, to which he devoted two business days per week.

Compensation Committee Report

                  The  Compensation  Committee  is  responsible  for setting the
Company's  policy  regarding the  compensation of the Company's senior executive
officers, including the Chief Executive Officer, and administering the Company's
stock option plans. The Company's policy is to establish a compensation  program
that will attract, retain and motivate qualified members of senior management in
a manner that is competitive with other companies in the biotechnology industry.
The key elements in this policy are salary, stock options, and availability of a
cash  bonus.  As the Company is still in the  development  stage,  revenues  and
profits are presently inapplicable as factors in determining compensation of the
Chief  Executive  Officer  and other  executives  of the  Company.  Rather,  the
Compensation  Committee  looks to qualitative  factors,  including the officers'
efforts to build the  organization,  to expand the Company's  potential  product
line (through  acquiring new technologies or otherwise),  to expand the range of
applications  therefor,  and to intensify the Company's research and development
efforts for its potential  products.  In determining the cash bonus for 1996 for
Richard L. Dunning,  the Company's Chief  Executive  Officer,  the  Compensation
Committee  considered a number of significant positive  developments  including,
among  other  factors,  the  completion  in June,  1996 of the  March  21,  1996
Subscription Agreement,  the redemption of the Class A and Class B Warrants, and
his overall  efforts in  building  the  Company's  organization,  including  the
acquisition  of Ribonetics  GmbH, the  acquisition of a controlling  interest in
Innovir and the recruitment of several key executives.

                           The Compensation Committee
                                Donald G. Drapkin
                               Richard L. Dunning
                               Eric A. Rose, M.D.
                           Lindsay A. Rosenwald, M.D.


                                       12
<PAGE>


         The above report shall not be deemed incorporated by reference into any
filing  under the  Securities  Act or under the  Exchange  Act,  by any  general
statement incorporating by reference this proxy statement,  except to the extent
the Company specifically  incorporates this information by reference,  and shall
not otherwise be deemed filed under such Acts.

Section 16 Proxy Statement Disclosure

         Section 16 of the Securities Exchange Act of 1934, as amended, requires
that  officers,  directors  and  holders  of more than 10% of the  Common  Stock
(collectively,  "Reporting  Persons")  file reports of their  trading in Company
equity securities with the Securities and Exchange Commission. Based on a review
of Section 16 forms filed by the Reporting  Persons during the last fiscal year,
David A. Jackson,  Executive Vice President and Chief Scientific  Officer of the
Company,  filed  his Form 3,  reporting  his  initial  beneficial  ownership  of
securities of the Company, approximately three and one-half months late, Francis
M. O'Connell,  Vice  President-Finance and Chief Financial Officer, filed a Form
4,  reporting  changes in  beneficial  ownership of  securities  of the Company,
approximately  one week late, Eric Rose, M.D., a director of the Company,  filed
his Form 5 reporting the exercise of warrants  approximately one month late. The
Company  believes  that  the  Reporting  Persons  otherwise  complied  with  all
applicable Section 16 filing requirements.


                              CERTAIN TRANSACTIONS

         In August 1995,  the Company  entered into a consulting  agreement with
Lindsay A.  Rosenwald,  M.D.,  who was elected a director of the Company in June
1996,  pursuant  to  which  Dr.  Rosenwald  has  agreed  to act  as a  financial
consultant to the Company  pursuant to the terms thereof and the Company granted
Dr. Rosenwald an option to purchase  2,000,000 shares of Common Stock at $.53125
per share (the  closing  bid price of the Common  Stock on The Nasdaq  Small-Cap
Market on the date preceding the date of grant),  exercisable  through August 6,
1998. In June 1996, Dr. Rosenwald  transferred  85,000 of the underlying  option
shares to other persons.

         In November  1995, the Company,  under the Company's 1995  Non-Employee
Director  Stock Option Plan,  issued  options to purchase  100,000 shares of the
Company's common stock, at an exercise price of $.9375 per share, to each of Mr.
Drapkin  and Dr.  Rose.  Such  options  may be  exercised  at any time  prior to
November, 2000, or if earlier, twelve months following cessation of service as a
director.

         In November 1995, the Company  entered into an arrangement  with Donald
G. Drapkin,  a director of the Company,  pursuant to which Mr. Drapkin agreed to
make available to the Company his business and financial  acumen for a five-year
period, and the Company granted Mr. Drapkin an option to purchase 650,000 shares
at $.9375 per share  (the  closing  bid price of the Common  Stock on The Nasdaq
Small Cap Market on the date  preceding the date of grant),  exercisable  at the
rate of 25% of the aggregate  number of underlying  shares per annum  commencing
one year  from the date of  grant.  Concurrently,  the  Company  entered  into a
five-year  consulting  arrangement  with Eric A. Rose,  M.D.,  a director of the
Company,  pursuant  to which Dr. Rose  agreed to provide  scientific  consulting
services to the Company,  and the Company granted Dr. Rose an option to purchase
650,000  shares  at  $.9375  per  share,  exercisable  at the rate of 25% of the
aggregate  number of underlying  shares per annum  commencing  one year from the
date of grant.

                                       13
<PAGE>

         In March 1996, Lindsay A. Rosenwald, M.D. and Donald G. Drapkin entered
into a Guaranty  Agreement with the Company  pursuant to which Dr. Rosenwald and
Mr.  Drapkin have each agreed to pay up to $1,000,000 of the Company's  ordinary
operating  expenses and in exchange for such  obligation  Dr.  Rosenwald and Mr.
Drapkin were each granted options to purchase  100,000 shares of Common Stock at
an  exercise  price of $1.47 per share.  Such  options are  exercisable  for ten
years.

         On June 21, 1996, the Company completed a private placement pursuant to
a subscription agreement dated March 21, 1996 (the "Subscription  Agreement") to
a group of investors  including the  following  directors or persons or entities
affiliated with such directors: (i) Laurence D. Fink, a director of the Company,
purchased  266,667  shares of Common  Stock and 133,333  Common  Stock  Purchase
Warrants for $400,000, and a family trust of Mr. Fink purchased 66,666 shares of
Common Stock and 33,333 Common Stock Purchase Warrants for $100,000;  (ii) Linda
G. Robinson, a director of the Company, purchased 133,333 shares of Common Stock
and 66,666 Common Stock Subscription Warrants for $200,000;  and (iii) The Aries
Trust Fund, a Cayman Island trust (the "Aries  Trust"),  and The Aries  Domestic
Fund, L.P., a Delaware limited partnership ("The Aries Limited Partnership" and,
together with the Aries Trust,  the "Aries  Funds"),  entities  affiliated  with
Lindsay A. Rosenwald,  M.D. and Jerome Groopman, M.D., directors of the Company,
in the manner  described  below,  purchased an  aggregate  of 666,666  shares of
Common Stock and 333,333 Common Stock Subscription  Warrants for an aggregate of
$1,000,000.  Lindsay A.  Rosenwald,  M.D., a director of the Company,  serves as
President and is sole shareholder of the investment  manager of the Aries Trust,
and serves as President and is the sole  shareholder  of the general  partner of
the  Aries  Limited  Partnership.  Jerome  Groopman,  M.D.,  a  director  of the
Registrant, is an interested party in the Aries Funds.

         On December 23, 1996, the Company acquired an approximate 66% ownership
interest in Innovir  Laboratories,  Inc.  ("Innovir")  pursuant to an  agreement
dated  November 21, 1996, as amended,  among the Company and the Aries Funds and
an agreement  dated November 21, 1996 between the Company and Innovir.  Pursuant
to the agreements,  as amended (i) the Aries Funds, which owned 4 million shares
of Innovir's common stock prior to the transaction,  exercised warrants and unit
purchase options to purchase an additional 6 million shares,  thereby  providing
$3 million in cash to Innovir and resulting in the Aries Funds owning 10 million
shares of Innovir's  common stock;  (ii) the Company acquired 9.5 million shares
of  Innovir's  common  stock  from the Aries  Funds for  $3,000,000  in cash and
3,000,000  newly issued  shares of the  Company's  Common  Stock,  and (iii) the
Company exchanged all of the capital stock of its wholly-owned subsidiary, VIMRX
Holdings Ltd., a Delaware  corporation ("VHL") (to which, prior to closing,  the
Company had made a capital  contribution of $4,000,000),  for 8.7 million shares
of Innovir's convertible preferred stock (convertible into 8.7 million shares of
Innovir's  common stock),  plus  five-year  warrants to purchase an additional 2
million shares of Innovir's  common stock (1 million shares at an exercise price
of $1.00  per  share and 1  million  shares  at an  exercise  price of $2.00 per
share).   The  Company  has  agreed  to  file  a  registration   statement  (the
"Registration  Statement")  with the  Securities  and Exchange  Commission  (the
"Commission")  for the public  resale of the  3,000,000  shares of Common  Stock
issued to the Aries  Funds,  to use its best  efforts to cause the  Registration
Statement to be declared effective by the Commission under the Securities Act as
soon as  practicable  and to use its  best  efforts  to  keep  the  Registration
Statement  effective  until the earlier of the date such shares  shall have been
disposed  of or the date on  which  all of such  shares  are  eligible  for sale
pursuant  to Rule  144  under  the  Securities  Act  (December  23,  1998).  The
acquisition  of the 9.5 million shares of Innovir stock from the Aries Funds was
negotiated  at arms' length with the Aries Funds and an opinion was issued by an
independent  investment  banking  firm  that the  transaction  was  fair  from a
financial point of view to the Company and its public shareholders.

                                       14
<PAGE>

         On March 7, 1997,  the Company  entered into a research  agreement with
Columbia  University   ("Columbia")   whereby  the  Company,   through  a  newly
established  subsidiary,  VIMRX Genomics,  Inc.  ("Genomics"),  90%-owned by the
Company  and  10%-owned  by  Columbia  University,  will  provide $30 million in
funding to the Columbia Genome Center established by Columbia, with $4.7 million
to be paid  during  the  first  year in  quarterly  installments.  In  exchange,
Genomics will receive an exclusive license to develop, manufacture, use, sell or
market products  resulting from any invention or research  product  developed by
the Columbia Genome Center and funded under the agreement.  Following an initial
five-year term, the agreement  automatically will renew for successive  two-year
terms and, in the absence of an agreement to the contrary, the amount of funding
will  be  increased  at a rate  of 9%  for  every  additional  year.  Under  the
agreement,  the Company agreed to issue  Columbia a one-time  payment of 200,000
shares of Common Stock, and granted  Columbia  "piggyback"  registration  rights
with respect to such shares during the period April 1, 1997 to April 1, 1999. On
March 26, 1997,  in a separate  transaction,  the Company  acquired an exclusive
worldwide  license from  Columbia  University  with respect to Blood Factor IXai
protein in consideration  for $100,000 and future royalties.  Concurrently,  the
Company  entered into a research  agreement to provide  Columbia $2.7 million in
funding in quarterly  installments over a three-year period for the research and
development  of Blood Factor IXai.  One of the  individuals  directing  research
under such agreement is Eric A. Rose,  M.D. a director of the Company.  Dr. Rose
is a Surgeon-In-Chief  at Columbia  Presbyterian  Medical Center in New York, an
affiliate of Columbia,  and has served as Chairman of the  Department of Surgery
at the  College of  Physicians  and  Surgeons  of  Columbia  since 1994 and as a
Director of the Division of Cardiothoracic Surgery of the Department since 1990.
Michael Weiner,  M.D., a director of the Company,  is the Hellinger Professor of
Clinical  Pediatrics at Columbia's  College of Physicians and Surgeons and is an
attending physician at Columbia Presbyterian Medical Center.

         The Company believes that the terms of the Subscription  Agreement were
no more  favorable to the investors than could have been obtained from unrelated
parties,  that the consulting  arrangements with Dr. Rosenwald,  Mr. Drapkin and
Dr. Rose are on terms no less  favorable  than could have been  negotiated  with
unrelated third parties of similar  expertise,  and the agreements with Columbia
were negotiated on an arm's length basis.


                       STOCK PRICE PERFORMANCE COMPARISON

         The Stock Price  Performance  Graph  below  compares  cumulative  total
return of the Company's Common Stock with the cumulative total return of (i) the
Index for the NASDAQ Stock Market (U.S. Companies) (the "NASDAQ Index") and (ii)
an industry peer group index consisting of the NASDAQ  Pharmaceutical Index (the
"Peer  Index").  The Graph  assumes $100 was invested on January 1, 1992, in (i)
the Company's Common Stock, (ii) the stocks comprising the NASDAQ Index and (ii)
the stocks comprising the Peer Index, and the reinvestment of dividends.


                                       15
<PAGE>






      [Insert performance graph described in Item 402(l) of Regulation S-K]















         The graph above shall not be deemed  incorporated by reference into any
filing  under the  Securities  Act or under the  Exchange  Act,  by any  general
statement incorporating by reference this proxy statement,  except to the extent
the Company specifically  incorporates this information by reference,  and shall
not otherwise be deemed filed under such Acts.

                  APPROVAL OF AMENDMENTS TO 1990 INCENTIVE AND
                         NON-INCENTIVE STOCK OPTION PLAN
                                       and
                         ADOPTION OF 1997 INCENTIVE AND
                         NON-INCENTIVE STOCK OPTION PLAN

General

         In 1990, the Company  adopted the 1990 Plan under which an aggregate of
500,000  shares of Common  Stock were  reserved for  issuance  upon  exercise of
options  granted  thereunder,  increased  to  1,200,000  shares  in 1991  and to
2,400,000  shares in 1996. In February 1997, the Board of Directors  adopted the
1997  Plan,  subject  to  stockholder  approval,  under  which an  aggregate  of
1,000,000  shares of Common Stock are reserved  for  issuance  upon  exercise of
options granted thereunder. The purpose of the 1990 Plan and of the 1997 Plan is
to further the growth and  development  of the Company by  encouraging  selected
employees,  directors  and other  persons  who  contribute  and are  expected to
contribute  materially to the Company's success to obtain a proprietary interest
in the Company  through  the  ownership  of its stock,  thereby  providing  such
persons with an added incentive to promote the best interests of the Company and
affording the Company a means of attracting  persons of  outstanding  ability to
its service.

                                       16
<PAGE>

         As of the Record  Date,  options to purchase an  aggregate of 1,952,500
shares of Common Stock had been granted and were  outstanding,  and a balance of
196,900  shares  are  reserved  for  issuance  under the 1990  Plan for  options
subsequently  granted  thereunder.  No options have been granted  under the 1997
Plan.


         1990 Plan and Proposed Amendments



                 On February 6, 1997, the Board of Directors adopted, subject to
stockholder approval,  amendments to the 1990 Plan (the "1990 Plan Amendments").
The purpose of the 1990 Plan  Amendments  is to conform the 1990 Plan to certain
statutory and regulatory developments, and to provide the Board of Directors and
the Compensation Committee with greater flexibility in determining the terms and
conditions of employee  options than was available  under the 1990 Plan prior to
the  amendments,  thereby  assisting  the Company in  attracting  to its service
persons of outstanding ability.  Following is a summary of the provisions of and
the amendments to the 1990 Plan:

 1.      Administration.   Prior  to  amendment,  the  1990  Plan  provided  for
         administration (i.e. granting of options and interpretation of the 1990
         Plan) by a committee (the  "Committee")  of the Board of Directors (the
         "Board"),  and for  amendment  or  termination  of the 1990 Plan by the
         Board.  As amended,  the Board may exercise the powers of the Committee
         described below, and thus administer the Plan directly.

 2.      Composition  of Committee.  Prior to amendment,  the 1990 Plan provided
         that the Committee be comprised of "disinterested directors" as defined
         in Rule  16b-3 and  "outside  directors"  as  defined  in the  Internal
         Revenue Code (the "Code").  As amended, to comply with recent revisions
         to  Rule  16b-3,  the  Committee  will  be  comprised,  to  the  extent
         practicable,  of "non-employee  directors" as defined by new Rule 16b-3
         "outside  directors" as defined in the Code. Mr. Drapkin,  Mr. Dunning,
         Dr.  Rose and Dr.  Rosenwald  currently  constitute  the members of the
         Committee.

 3.      Powers of the  Committee.  The  Committee  selects  the  optionees  and
         determines (i) whether the respective  option is to be a  non-incentive
         stock option or an  incentive  stock option  qualifying  under  Section
         422(a)  of the  Code,  (ii)  the  number  of  shares  of  Common  Stock
         purchasable  under the option,  which may not exceed 800,000 shares for
         any individual, and (iii) the exercise price, which cannot be less than
         50% of the fair market  value of the Common  Stock on the date of grant
         for  non-incentive  stock options or 100% of such fair market value for
         incentive   stock   options.   With   respect  to  the  granting  of  a
         non-incentive  stock option,  the Committee further  determines (i) the
         time or  times  when  the  option  becomes  exercisable,  and  (ii) its
         duration, which may not exceed ten years from the date of grant.

         As amended,  in addition to the powers  described  above, the Committee
         shall  determine  the  expiration  dates of options  (not to exceed ten
         years from the date of grant) and,  for  non-incentive  stock  options,
         whether such options will have limited  transferability.  The Committee
         also shall have the power to accelerate exercisability, extend the term
         of  exercisability  and otherwise  amend the  provisions of outstanding
         options, subject to the terms of the 1990 Plan, as amended.

                                       17
<PAGE>

 4.      Eligibility for Option Grants.  Non-incentive options may be granted to
         employees, directors,  consultants, agents, independent contractors and
         such  other  persons  as  the  Committee  determines  will  assist  the
         Company's endeavors. This provision has not been amended.

5.       Exercise Price of Options. With respect to incentive stock options, the
         fair market value, determined as of the date the option was granted, of
         shares first  exercisable  by an optionee in any calendar  year may not
         exceed $100,000.  The maximum number of shares of Common Stock that may
         be subject  to  options  granted  to an  executive  officer  during any
         calendar year is 800,000 shares. This provision has not been amended.

6.       Term of Incentive  Stock  Options.  Prior to  amendment,  the 1990 Plan
         provided limited the term of incentive stock options to five years from
         the  date of  grant.  As  amended,  the  terms  of both  incentive  and
         non-incentive options may be as long as ten years, as determined by the
         Committee at the date of grant.

7.       Exercisability of Incentive Stock Options. Prior to amendment, the 1990
         Plan provided that  incentive  stock options be exercisable at the rate
         of 25% per  annum  commencing  one  year  from the  date of  grant.  As
         amended,  the  Committee  will  determine  the  exercisability  of each
         option,  provided,  however,  that no option will be exercisable  for a
         period of six months from the date of grant (the same limitation  being
         applicable to non-incentive stock options).

8.       Acceleration of Exercisability of Options. Prior to amendment, the 1990
         Plan  made no  provision  for the  acceleration  of  exercisability  of
         outstanding  options.  As  amended,  the 1990  Plan  provides  that the
         Committee,  in its  discretion,  may accelerate the  exercisability  of
         outstanding  options,  subject to the  $100,000  per annum market value
         limitation for incentive stock options.

9.       Cashless Exercises. Prior to amendment, the 1990 Plan required exercise
         of options by delivery of cash in the amount of the exercise  price. As
         amended,  the  1990  Plan  permits,  to the  extent  determined  by the
         Committee for individual option grants,  exercisability by the delivery
         of  previously  owned  shares or the  withholding  of shares  otherwise
         issuable upon exercise of the option (so-called "cashless exercises").

10.      Extension of Exercisability. Prior to amendment, the 1990 Plan provided
         that an option automatically  terminate three months following the date
         of the  optionee's  termination  of employment  or engagement  with the
         Company, and one year following an employee's death or disability,  but
         in no  event  subsequent  to the  expiration  date  of the  option.  As
         amended,  the  Committee,  in its  discretion,  may  extend the term of
         exercise of an outstanding  non-incentive  stock option, but not beyond
         ten years from the date of the non-incentive stock option's grant.

 11.     Transferability.  Prior to  amendment,  the 1990 Plan  provided that no
         option be  transferable  other than by will or the laws of descent  and
         distribution.  As  amended,  the  Committee  may  provide  for  limited
         transferability   (i.e.  to  family   members  or  family   trusts)  of
         non-incentive stock options.

12.      Change in Control. Prior to amendment, the 1990 Plan provided that upon
         a change in control of the Company,  the 1990 Plan and all  outstanding
         options  automatically would terminate unless provided otherwise by the
         Committee at the time of grant.  As amended,  upon a change in control,
         the exercisability of all outstanding  options shall be accelerated and
         such options shall become immediately fully exercisable.

                                       18
<PAGE>

 13.     Option  Adjustments.  The 1990 Plan contains a customary  anti-dilution
         provision  which  provides  that  in the  event  of any  change  in the
         Company's  outstanding  capital  stock by  reason  of  stock  dividend,
         recapitalization,   merger,  consolidation,  split-up,  combination  or
         exchange  of shares  and the like,  the  aggregate  number of shares of
         Common Stock subject to outstanding options and the option price are to
         be appropriately adjusted by the Committee, whose determination thereon
         shall be conclusive. This provision was not amended.

 14.     Subsequent  Amendments to 1990 Plan. Prior to amendment,  the 1990 Plan
         provided  that the Board may make  modifications  or  amendments to the
         1990  Plan,  provided,  however,  that (i) no change may be made in the
         aggregate  number of shares of Common  Stock  subject to the 1990 Plan,
         (ii) no termination, modification or amendment may adversely affect the
         rights of a holder under a previously granted option, (iii) no material
         modification  may be  made  to the  requirements  for  eligibility  for
         participation  in the 1990 Plan,  and (iv) no material  increase may be
         made in the  benefits  accruing to  participants  in the 1990 Plan.  As
         amended,  the Board will be empowered to amend the 1990 Plan, provided,
         however,  that  shareholder  approval shall be required (i) to increase
         the number of shares reserved for issuance under the 1990 Plan, (ii) to
         materially  increase the benefits  accruing to participants in the 1990
         Plan,  (iii) to materially  modify the requirements for eligibility for
         participation  under the 1990 Plan,  or (iv) if  otherwise  required to
         comply with the incentive stock option  provisions or Section 162(m) of
         the Code or the listed company  requirements of The Nasdaq Stock Market
         or of a  national  securities  exchange  on which the  Common  Stock is
         traded, and provided,  further,  that no amendment may adversely affect
         the rights of a holder of an  outstanding  option without such holder's
         written consent.


         Options Granted or to be Granted Under the 1990 Plan

         As of the Record  Date,  options to purchase an  aggregate of 1,952,500
shares of Common  Stock had been  granted  and were  outstanding,  including  an
incentive option to purchase  156,064 shares granted and a non-incentive  option
to purchase  643,936 shares to Richard L. Dunning,  the Company's  President and
Chief Executive Officer. See "Executive Compensation - Employment Arrangements."
Dr. David A. Jackson,  Executive Vice President and Chief Scientific Officer has
been issued  incentive  options to purchase  120,752 shares,  and  non-incentive
options to purchase  379,248  shares.  Other than Mr.  Dunning and Dr.  Jackson,
current  executive  officers  (consisting  of Dr.  Richard  Kouri,  Senior  Vice
President - Research,  Francis M. O'Connell,  Vice  President-Finance  and Chief
Financial  Officer,  and Dr. Alfonso J. Tobia,  Executive Vice President),  hold
incentive  stock options under the 1990 Plan to purchase an aggregate of 325,000
shares,  which were granted as follows:  (i) on March 27, 1995, an option to Mr.
O'Connell to purchase  100,000  shares at an exercise  price of $.428 per share,
under which 50,000 shares are currently exercisable; (ii) on August 24, 1994, an
option to Dr. Tobia to purchase  150,000 shares at an exercise price of $.69 per
share, under which 75,000 shares are currently exercisable;  and (iii) on May 5,
1997, an option to Dr. Kouri to purchase  75,000 shares at an exercise  price of
$2.125 per share, none of which are currently exercisable.

         On May 14, 1997,  the most recent  practical date prior to the printing
of this Proxy  Statement,  the closing  sale price per share of Common  Stock as
reported by The Nasdaq National Market was $2.66.



                                       19
<PAGE>





         1997 Plan

         The 1997 Plan is  substantially  identical  to the 1990 Plan,  with the
         following exceptions:

1.       The 1997 Plan was adopted in February,  1997 and provides  that options
         may be granted thereunder until February,  2007; Options under the 1990
         Plan may be granted only until July, 2000.

2.       One Million  (1,000,000)  shares are  authorized for issuance under the
         1997 Plan;  Two Million Four Hundred  Thousand  (2,400,000)  shares are
         authorized for issuance under the 1990 Plan.

3.       No options have yet been issued under the 1997 Plan.


Federal Income Tax Consequences

         The  following  is based  upon  federal  tax laws  and  regulations  as
presently  in effect and does not  purport to be a complete  description  of the
federal income tax aspects of the 1990 Plan and the 1997 Plan (collectively, the
"Plans").  Also, the specific state tax consequences to each  participant  under
the  Plans may  vary,  depending  upon the laws of the  various  states  and the
individual circumstances of each participant.

         Incentive Stock Options

         No taxable  income is  recognized  by the optionee upon the grant of an
incentive  stock  option  under the Plans.  Further,  no taxable  income will be
recognized by the optionee upon  exercise of an incentive  stock option  granted
under the Plans and no  expense  deduction  will be  available  to the  Company.
Generally,  if the optionee holds shares acquired upon the exercise of incentive
stock  options  for at least two (2) years  from the date of grant of the option
and  for at  least  one (1)  year  from  the  date of  exercise,  any  gain on a
subsequent sale of such shares will be considered as long-term capital gain. The
gain recognized upon the sale of the shares is equal to the excess of the amount
realized  upon the sale,  selling  price of the shares over the exercise  price.
Therefore,  the net federal income tax effect on the holders of incentive  stock
options is to defer, until the shares are sold,  taxation of any increase in the
value of the shares  from the date of grant and to treat such gain,  at the time
of sale, as capital gain rather than ordinary income.  However,  in general,  if
the  optionee  sells the shares  prior to  expiration  of either the two-year or
one-year period, referred to as a "disqualifying disposition," the optionee will
recognize  taxable income at ordinary tax rates in an amount equal to the lesser
of (i) the value of the shares on the date of exercise, less the exercise price;
or (ii) the amount realized on the date of sale,  less the exercise  price,  and
the Company will receive a corresponding business expense deduction. The balance
of the gain  recognized on the  disqualifying  disposition  will be long-term or
short-term  capital  gain  depending  upon the  holding  period of the  optioned
shares.  The two-year and one-year holding period rules do not apply to optioned
shares which are disposed of by the  optionee's  estate or a person who acquired
such shares by reason of the death of the optionee.

         An employee may be subject to an alternative  minimum tax upon exercise
of an  incentive  stock  option since the excess of the fair market value of the
optioned  stock at the date of exercise over the exercise price must be included
in alternative  minimum taxable income,  unless the acquired shares are disposed
of in the same year that the option was exercised.


                                       20
<PAGE>

         Non-Incentive Stock Options

         As in the case of incentive stock options,  the grant of  non-incentive
stock options will not result in any taxable  income to the  optionee.  However,
unlike incentive stock options,  generally the optionee will recognize  ordinary
income in the year in which the option is  exercised  in the amount by which the
fair market value of the  purchased  shares on the date of exercise  exceeds the
exercise price.

         The fair  market  value of the shares on the date income is required to
be recognized  will  constitute the tax basis thereof for computing gain or loss
on any  subsequent  sale.  Any gain or loss  recognized by the optionee upon the
subsequent disposition of the shares will be treated as capital gain or loss and
will qualify as  long-term  capital gain or loss if the shares are held for more
than twelve months prior to disposition.

         Generally, the Company will be entitled to a business expense deduction
equal to the amount of ordinary income recognized by the optionee at the date of
exercise.  The income recognized by the optionee will be treated as compensation
income and will be subject to income tax withholding by the Company.

         Section 162(m) of the Code

         Under Section  162(m) of the Internal  Revenue Code of 1986, as amended
(the "Code"),  certain compensation payments in excess of $1 million are subject
to  a  limitation  on   deductibility   for  the  Company.   The  limitation  on
deductibility applies with respect to that portion of a compensation payment for
a taxable year in excess of $1 million to either the Company's  Chief  Executive
Officer or any one of the Company's other four most highly compensated executive
officers.   Certain  performance-based   compensation  is  not  subject  to  the
limitation  on  deductibility.  Options can  qualify for this  performance-based
exception,  but only if they are granted at fair market value,  the total number
of shares that can be granted to an executive for a specified  period is stated,
and  shareholder  and Board approval of the plan under which they are granted is
obtained.  The Plans  allow  compliance  with those  performance-based  criteria
except that non-qualified stock options granted with an exercise price less than
the fair  market  value of the  Common  Stock on the date of grant will not meet
such performance-based criteria and, accordingly,  the compensation attributable
to such options will be subject to the  deductibility  limitations  contained in
Section 162(m) of the Code.




         At the date of this Proxy Statement, long-term capital gain is taxed to
individuals  at a maximum  preferential  rate of 28%,  while  items of  ordinary
income are currently taxed to individuals at a maximum rate of 39.6%.




Required Vote

         Approval of the  amendments to the 1990 Plan and of the adoption of the
1997 Plan will require the affirmative  vote of the holders of a majority of the
outstanding  shares of Common Stock present in person or represented by proxy at
the Meeting and entitled to vote. In instances where brokers are prohibited from
exercising  discretionary  authority for beneficial owners who have not returned
proxies  ("broker  non-votes"),  those  shares  will not be included in the vote
totals,  and  therefore  will have no effect on the vote for the approval of the
1990 Plan  Amendments  or the approval of the adoption of the 1997 Plan.  Unless
marked to the contrary,  proxies received will be voted FOR approval of the 1990
Plan Amendments and FOR approval of the adoption of the 1997 Plan.



                                       21
<PAGE>

         The  Board  of  Directors  recommends  that  stockholders  vote FOR the
approval of the 1990 Plan  Amendments  and FOR  approval of the  adoption of the
1997 Plan.


               RATIFICATION OF APPOINTMENT OF INDEPENDENT AUDITORS


         Subject to ratification by the stockholders, the Board of Directors has
appointed  KPMG Peat  Marwick LLP as  independent  auditors  for the year ending
December 31, 1997.

         For more than the two most  recent  fiscal  years of the  Company,  the
independent auditors of the Company have been Richard A. Eisner & Company,  LLP,
who have been dismissed upon  recommendation  of the Audit  Committee on May 15,
1997 At no time did any report on the  financial  statements  of the  Company by
Richard A. Eisner & Company,  LLP contain an adverse  opinion or a disclaimer of
opinion,  or a qualification  or modification as to uncertainty,  audit scope or
accounting principles.  The decision to change accountants was occasioned by the
developments  of the past year, and not by any  disagreement  or advice given on
any  matter  of  accounting   principles  or  practices,   financial   statement
disclosure,  or auditing  scope or  procedure.  In  particular,  in light of the
acquisition  by the Company of a controlling  interest in Innovir  Laboratories,
Inc. the Audit  Committee  concluded  that it would be most efficient and in the
best  interests of both  Innovir and the Company for the same  auditors to audit
both  companies.  The Company  solicited  proposals  from four  auditing  firms,
including Richard A. Eisner & Company,  LLP. KPMG Peat Marwick LLP was chosen as
a result of this  process,  and was  engaged  by the  Company  as its  principal
auditors on May 15, 1997.

         The  ratification  of the  appointment  of KPMG Peat  Marwick  LLP will
require the affirmative vote of a majority of the shares of Common Stock present
in person or  represented  by proxy at the  Meeting  and  entitled  to vote.  In
instances where brokers are prohibited from exercising  discretionary  authority
for beneficial owners who have not returned proxies ("broker non-votes"),  those
shares will not be included in the vote totals and therefore will have no effect
on the ratification of the reappointment of the independent auditors.

         It is anticipated that a  representative  of KPMG Peat Marwick LLP will
be present at the  Meeting  to answer  questions  within  such  firm's  field of
expertise.

         The  Board  of  Directors  recommends  that  stockholders  vote FOR the
appointment of KPMG Peat Marwick LLP as independent auditors for the year ending
December 31, 1997.


                                 OTHER BUSINESS

         Management does not know of any matter to be brought before the Meeting
other than as  described  above.  In the event any other matter  properly  comes
before the Meeting,  the persons  named in the  accompanying  form of proxy have
discretionary authority to vote on such matters.


                                       22
<PAGE>

                              STOCKHOLDER PROPOSALS

         Any  stockholder  proposal  to  be  considered  for  inclusion  in  the
Company's proxy soliciting  material for the next Annual Meeting of Stockholders
must be received by the Company at its principal office by December 31, 1997.

Dated:  May 21,1997




                                       23
<PAGE>






                                                                     EXHIBIT A




                              AMENDED AND RESTATED


                        1990 INCENTIVE AND NON-INCENTIVE

                                STOCK OPTION PLAN

                                       OF

                           VIMRx PHARMACEUTICALS INC.

             (AS AMENDED JULY 15, 1991, AUGUST 31, 1995 MAY 13, 1996
                              AND FEBRUARY 6, 1997)


         1.       Purpose of Plan.

                  The purpose of this Incentive and  Non-Incentive  Stock Option
Plan ("Plan") is to further the growth and development of VIMRx  Pharmaceuticals
Inc. ("Company") and any subsidiaries thereof by encouraging selected employees,
directors  and other  persons who  contribute  and are  expected  to  contribute
materially  to the  Company's  success to obtain a  proprietary  interest in the
Company through the ownership of stock,  thereby  providing such persons with an
added  incentive to promote the best  interests of the Company and affording the
Company a means of attracting to its service persons of outstanding ability.

         2.       Stock Subject to the Plan.

                  An  aggregate  of  2,400,000  shares of the  Company's  Common
Stock,  $.001 par value  ("Common  Stock")  subject,  however,  to adjustment or
change pursuant to paragraph 12 hereof,  shall be reserved for issuance upon the
exercise of options  which may be granted from time to time in  accordance  with
the Plan  ("Options").  Such shares may be, in whole or in part,  authorized but
unissued shares or issued shares which have been reacquired by the Company.  If,
for any reason,  an Option shall lapse,  expire or terminate without having been
exercised  in full,  the  unpurchased  shares  covered  thereby  shall  again be
available for purposes of the Plan.

         3.       Administration.

                  (a) Except as provided in paragraph (c) below,  the Plan shall
be  administered  by the  Committee.  The Board of Directors  shall  appoint the
Committee  from among its members.  Such  Committee  shall be composed of two or
more Directors who, to the extent  practicable,  shall be "outside directors" as
defined in  regulations  under  Section  162(m) of the Internal  Revenue Code of
1986,  as amended  (the  "Code"),  and  "non-employee  directors"  as defined by
Regulation 240.16b-3 under the Securities Exchange Act of 1934, as amended. Such
Committee  shall have and may exercise any and all of the powers relating to the
administration of the Plan and the grant of Options  thereunder as are set forth
in subparagraph 3(b) hereof as the Board of Directors shall confer and delegate.
The Board of  Directors  shall have power at any time to fill  vacancies  in, to
change the membership of, or to discharge such  Committee.  The Committee  shall
select one of its members as its  chairman  and shall hold its  meetings at such
time and at such places as it shall deem advisable. A majority of such Committee
shall  constitute a quorum and such majority  shall  determine  its action.  Any
action may be taken  without a meeting by written  consent of all the members of
the Committee.  The Committee  shall keep minutes of its  proceedings  and shall
report the same to the Board of Directors at the meeting next succeeding.

                  (b) The Committee  shall  administer the Plan and,  subject to
the  provisions  of the Plan,  shall have sole  authority in its  discretion  to
determine the persons to whom, and the time or times at which,  Options shall be
granted;  the number of shares to be subject to each such Option; the provisions
regarding  exercisability  of each Option;  the expiration  date of each Option;
whether the Option shall contain a "cashless exercise" provision; whether all or
any  portion  of the  Options  shall  be  incentive  stock  options  ("Incentive
Options")  qualifying  under  Section 422A of the Code or stock options which do
not so qualify ("Non-Incentive  Options");  whether a Non-Incentive Option shall
have  limited  transferability  as  permitted  under  the  Plan;  and  whether a
Non-Incentive  Option granted to a non-employee  shall  terminate  following the
non-employee's  termination of engagement in performing services for the Company
or its  subsidiaries  pursuant to Section 9 of the Plan. Both Incentive  Options
and  Non-Incentive  Options  may be granted to the same  person at the same time
provided   each  type  of  Option  is  clearly   designated.   In  making   such
determinations,  the  Committee may take into account the nature of the services
rendered by such  persons,  their  present  and  potential  contribution  to the
Company's success and such other factors as the Committee in its sole discretion
may deem relevant.  Subject to the express provisions of the Plan, the Committee
shall also have authority to interpret the Plan; to prescribe, amend and rescind
rules and regulations relating thereto; to determine the terms and provisions of
the respective  Option  Agreements,  which shall be  substantially  in the forms
attached  hereto  as  Exhibit  A and  Exhibit  B; to  amend  the  provisions  of
outstanding  Options to provide for accelerated  exercisability or the extension
of the  expiration  date of such Options;  and to make all other  determinations
necessary  or  advisable  for  the  administration  of the  Plan,  all of  which
determinations shall be conclusive and not subject to review.

                  (c) The Board of Directors may administer the Plan, in lieu of
and with the same powers as the Committee,  with respect to any Options  granted
or to be granted under the Plan, provided that such administration is consistent
with the provisions of Section 162(m) of the Code.

         4.       Eligibility for Receipt of Options.

                  (a) Incentive  Options.  Incentive Options may be granted only
to employees (including officers) of the Company and/or any of its subsidiaries.
A  director  of the  Company or any  subsidiary  who is not an  employee  of the
Company or of one of its  subsidiaries  is not  eligible  to  receive  Incentive
Options  under the Plan.  Further,  Incentive  Options may not be granted to any
person who, at the time the Incentive Option is granted,  owns (or is considered
as owning  within the meaning of Section  425(d) of the Code)  stock  possessing
more than 10% of the total combined  voting power of all classes of stock of the
Company or any subsidiary (10% Owner),  unless at the time the Incentive  Option
is  granted  to the 10%  Owner,  the  option  price is at least 110% of the fair
market value of the Common Stock subject  thereto and such  Incentive  Option by
its terms is not  exercisable  subsequent  to five years from the date of grant.
The aggregate fair market value  (determined as of the time an Incentive  Option
is granted) of the shares of the Company's  Common Stock  initially  purchasable
upon  exercise of an Incentive  Option  during any calendar  year may not exceed
$100,000.

                  (b)  Non-Incentive  Options.   Non-Incentive  Options  may  be
granted to any employees  (including  employees who have been granted  Incentive
Options),  directors,  consultants,  agents,  independent  contractors and other
persons whom the Board of Directors (or Committee) determines will contribute to
the Company's success.

                  (c) The  maximum  number  of  shares  that may be  subject  to
options  under this Plan  granted  during  any  calendar  year to any  executive
officer of the Company is 800,000 shares.

                  (d) In the event on outstanding  Incentive Option or a portion
thereof no longer  qualifies as an incentive  stock option under Section 422A of
the Code, such Option or portion  thereof,  as applicable,  thereafter  shall be
deemed a Non-Incentive Option under the Plan.

         5.       Option Price.

                  The  purchase  price of the shares of Common  Stock under each
Option  shall be  determined  by the  Committee,  which  determination  shall be
conclusive  and not subject to review,  but in no event shall the purchase price
be less than 100% of the fair  market  value of the Common  Stock on the date of
grant in the case of Incentive Options (110% of fair market value in the case of
Incentive  Options  granted to a 10% Owner) and 50% of the fair market  value of
the Common Stock on the date of the grant in the case of Non-Incentive Options.

                  For  purposes  of the Plan,  unless the  Committee  determines
otherwise,  the "fair  market  value" of a share of Common Stock as of a certain
date shall be the  closing  sale price of the Common  Stock on The Nasdaq  Stock
Market or, if the Common  Stock is not then traded on The Nasdaq  Stock  Market,
such national  securities  exchange on which the Common Stock is then traded, on
the trading  date  immediately  preceding  the date fair  market  value is being
determined.  The  Committee  may make such other  determination  of fair  market
value, based on other factors, as it shall deem appropriate.

                  For purposes of the Plan, the date of grant of an Option shall
be the date on which the  Committee  shall by  resolution  duly  authorize  such
Option.



         6.       Term of Options.

                  The term of each  Option  shall be such number of years as the
Committee shall  determine,  subject to earlier  termination as herein provided,
but in no event more than ten years from the date such Option is granted.

         7.       Exercise of Options.

                  (a) Each Option shall be exercisable to the extent  determined
by the Committee,  but in no event shall an Option be exercisable until at least
six months from the date of grant.

                  (b) An Option may not be exercised for fractional shares of 
the Company's Common Stock.

                  (c) Except as provided in paragraphs 9, 10 and 11 hereof,  and
unless  determined  otherwise by the  Committee  with  respect to  Non-Incentive
Options  granted to  non-employees,  no Option shall be  exercisable  unless the
holder  thereof  shall  have  been an  employee,  director,  consultant,  agent,
independent  contractor  or other  person  employed by or engaged in  performing
services for the Company and/or a subsidiary continuously from the date of grant
to the date of exercise.

                  (d) The exercise of an Option shall be contingent upon receipt
from the  holder  thereof of a written  representation  that at the time of such
exercise  it is the  optionee's  then  present  intention  to acquire the Option
shares for investment and not with a view to the  distribution or resale thereof
(unless a Registration  Statement  covering the shares purchasable upon exercise
of the Options shall have been declared effective by the Securities and Exchange
Commission)  and upon  receipt by the Company of cash,  or a check to its order,
for  the  full  purchase  price  of  such  shares.  The  Committee  may,  in its
discretion,  include a "cashless  exercise"  provision in the applicable  Option
Agreement,  in  which  event  the  optionee  will be  permitted  (i) to  deliver
previously  owned  shares of Common  Stock with a fair market value equal to the
exercise price in payment of the full purchase price of such shares,  or (ii) to
request that the Company  withhold shares of Common Stock issuable upon exercise
of such  Option  with a fair market  value  equal to the  exercise  price of the
shares being purchased  under the Option (thereby  reducing the number of shares
issuable upon exercise of the Option).

                  (e) The holder of an Option shall have none of the rights of a
stockholder  with respect to the shares  purchasable upon exercise of the Option
until a  certificate  for such shares  shall have been issued to the holder upon
due exercise of the Option.

                  (f) The proceeds  received by the Company upon  exercise of an
Option shall be added to the  Company's  working  capital and be  available  for
general corporate purposes.

         8.       Transferability of Options.

                  No Option granted  pursuant to the Plan shall be  transferable
otherwise than by will or the laws of descent or distribution  and an Option may
be exercised  during the  lifetime of the holder only by such holder,  provided,
however,  that the Committee may provide for  transferability of a Non-Incentive
Option to an optionee's family members or family trusts.

         9.       Termination of Employment or Engagement.

                  (a) Except as provided in  paragraph  (b) below,  In the event
the  employment of the holder of an Option shall be terminated by the Company or
a subsidiary for any reason other than by reason of death or disability,  or the
engagement  of  a  non-employee  holder  of  a  Non-Incentive  Option  shall  be
terminated  by the  Company or a  subsidiary  for any  reason,  such holder may,
within three months from the date of such  termination,  exercise such Option to
the  extent  such  Option  was  exercisable  by such  holder at the date of such
termination.   Notwithstanding  the  foregoing,   no  Option  may  be  exercised
subsequent  to the date of its  expiration.  Absence  on leave  approved  by the
employer  corporation  shall not be considered an interruption of employment for
any purpose under the Plan. In addition, at the discretion of the Committee, the
exercisability of an outstanding  Non-Incentive Option may be extended to a date
determined by the Committee but not beyond ten years from the date of grant.

                  (b) The Committee may, in its discretion, at the time of grant
or by amending  the  applicable  outstanding  Non-Incentive  Option,  delete the
foregoing  termination  provision with respect to a Non-Incentive Option granted
to a non-employee of the Company or its subsidiaries.

                  (c)  Nothing  in the Plan or in any Option  Agreement  granted
hereunder shall confer upon any Optionholder any right to continue in the employ
of the Company or any  subsidiary  or obligate the Company or any  subsidiary to
continue the  engagement  of any  Optionholder  or interfere in any way with the
right of the Company or any such  subsidiary  to terminate  such  Optionholder's
employment or engagement at any time.

         10.      Disability of Holder of Option.

                  If  the  employment  of  the  holder  of an  Option  shall  be
terminated by reason of such holder's disability, such holder may, within twelve
months  from the date of such  termination,  exercise  such option to the extent
such  Option was  exercisable  by such  holder at the date of such  termination.
Notwithstanding the foregoing, no Option may be exercised subsequent to the date
of its expiration.

         11.      Death of Holder of Option.

                  If the holder of any Option  shall die while in the employ of,
or while performing services for, the Company or one or more of its subsidiaries
(or within six months  following  termination of employment due to  disability),
the Option theretofore granted to such person may be exercised,  but only to the
extent such Option was  exercisable by the holder at the date of death (or, with
respect to employees,  the date of  termination of employment due to disability)
by the legatee or legatees of such person under such  person's  Last Will, or by
such person's personal representative or distributees, within twelve months from
the  date of death  but in no event  subsequent  to the  expiration  date of the
Option.

         12.      Adjustments Upon Changes in Capitalization.

                  If at any time  after  the date of  grant  of an  Option,  the
Company shall by stock  dividend,  split-up,  combination,  reclassification  or
exchange, or through merger or consolidation or otherwise,  change its shares of
Common  Stock  into a  different  number  or kind or  class of  shares  or other
securities or property, then the number of shares covered by such Option and the
price per share thereof shall be proportionately adjusted for any such change by
the Committee whose determination thereon shall be conclusive.

         13.      Acceleration of Exercisability Upon Change in Control.

                  Upon the  occurrence  of a "change in  control" of the Company
(as defined  below),  all  outstanding  Options shall become  immediately  fully
exercisable.  For  purposes  of the Plan,  a "change in  control" of the Company
shall mean (i) the  acquisition  at any time by a "person"  or "group"  (as such
terms are used  Sections  13(d) and 14(d)(2) of the  Exchange Act of  beneficial
ownership  (as  defined in Rule  13d-3  under the  Exchange  Act),  directly  or
indirectly,  of securities representing 50% or more of the combined voting power
in the election of directors of the then  outstanding  securities of the Company
or any successor or the Company;  (ii) the  termination of service of directors,
for any reason  other than death,  disability  or  retirement  from the Board of
Directors,  during any period of two  consecutive  years or less, of individuals
who at the  beginning  of such  period  constituted  a majority  of the Board of
Directors,  unless  the  election  of or  nomination  for  election  of each new
director during such period was approved by a vote of at least two-thirds of the
directors  still in office who were  directors  at the  beginning of the period;
(iii) approval by the stockholders of the Company of any merger,  consolidation,
or  statutory  share  exchange  as a result of which the Common  Stock  shall be
changed,  converted or exchanged  (other than a merger,  consolidation  or share
exchange with a  wholly-owned  Subsidiary)  or liquidation of the Company or any
sale or  disposition  of 80% or more  of the  assets  or  earning  power  or the
Company;  or (iv)  approval  by the  stockholders  of the Company of any merger,
consolidation,  or statutory share exchange to which the Company is a party as a
result of which  the  persons  who were  stockholders  immediately  prior to the
effective  date of the  merger,  consolidation  or  share  exchange  shall  have
beneficial  ownership  of less  than  50% of the  combined  voting  power in the
election of directors of the surviving corporation;  provided,  however, that no
change in control  shall be deemed to have  occurred if, prior to such time as a
change in control  would  otherwise be deemed to have  occurred,  the  Company's
Board of Directors deems otherwise.




<PAGE>



         14.      Vesting of Rights Under Options.


                  Neither  anything  contained in the Plan nor in any resolution
adopted  or to be  adopted  by the  Committee,  the  Board of  Directors  or the
stockholders of the Company shall constitute the vesting of any rights under any
Option.  The vesting of such rights shall take place only when a written  Option
Agreement,  substantially  in the form of the Incentive  Stock Option  Agreement
attached  hereto  as  Exhibit  A or the  Non-Incentive  Stock  Option  Agreement
attached  hereto as Exhibit B, shall be duly  executed  and  delivered by and on
behalf of the Company and the person to whom the Option shall be granted.

         15.      Withholding Taxes.

                  Whenever   under  the  Plan   shares   are  to  be  issued  in
satisfaction  of the exercise of Options granted  thereunder,  the Company shall
have the  right to  require  the  recipient  to remit to the  Company  an amount
sufficient to satisfy  federal,  state and local  withholding  tax  requirements
prior to the delivery of any certificate or certificates for such shares.

         16.      Termination and Amendment.

                  The Plan,  which was adopted by the Board of Directors on July
10, 1990 and approved by the  shareholders  of the Company,  shall  terminate on
July 9, 2000 and no Option shall be granted under the Plan after such date.  The
Board of Directors may at any time prior to such date terminate the Plan or make
such modifications or amendments  thereto as it shall deem advisable,  provided,
however, that shareholder approval shall be required:

         (i)      to increase the number of shares reserved for issuance under 
                  the Plan;

         (ii)     to materially increase the benefits accruing to participants 
                  under the Plan;

        (iii)     to materially modify the requirements of eligibility for 
                  participation in the Plan; or

         (iv)     if  otherwise  required  to comply  with the  incentive  stock
                  option  provisions of Section 162(m) of the Code or the listed
                  company  requirements  of  The  Nasdaq  Stock  Market  or of a
                  national securities exchange on which the Common Stock is then
                  traded,

and, provided, further, that no modification or amendment shall adversely affect
the rights of a holder of an Option  previously  granted  under the Plan without
such holder's written consent.



<PAGE>









                                                          EXHIBIT A TO 1990 PLAN

                           VIMRx PHARMACEUTICALS INC.

                        INCENTIVE STOCK OPTION AGREEMENT

                             ----------------------

To:

                  We are pleased to notify you that by the  determination of the
Stock Option Plan Committee  (hereinafter  the  "Committee")  an incentive stock
option to  purchase  shares of the Common  Stock of VIMRx  Pharmaceuticals  Inc.
(herein called the "Company") at a price of $ per share has this day of
                   been granted to you under the  Company's  1990  Incentive and
Non-Incentive  Stock Option Plan (herein called the "Plan").  This option may be
exercised only upon the terms and conditions set forth below.


<PAGE>






                  1.        Purpose of Option.

                  The  purpose of the Plan  under  which  this  incentive  stock
option has been granted is to further the growth and  development of the Company
and its  subsidiaries  by  encouraging  key employees,  directors,  consultants,
agents,  independent  contractors  and  other  persons  who  contribute  and are
expected  to  contribute  materially  to  the  Company's  success  to  obtain  a
proprietary  interest in the Company  through the  ownership  of stock,  thereby
providing such persons with an added  incentive to promote the best interests of
the Company,  and  affording  the Company a means of  attracting  to its service
persons of outstanding ability.


                  2.       Acceptance of Option Agreement.

                  Your execution of this incentive  stock option  agreement will
indicate your  acceptance of and your  willingness to be bound by its terms;  it
imposes no  obligation  upon you to purchase  any of the shares  subject to this
option.  Your obligation to purchase shares can arise only upon your exercise of
the option in the manner set forth in paragraph 4 hereof.


                  3.       When Option May Be Exercised.

                  (a) The option  granted you hereunder may not be exercised for
a period of six months from the date of its grant by the  Committee as set forth
above. Thereafter, this option shall be exercisable as follows:


 [Insert exercisability  provisions.  A typical  example,  although not required
         under the Plan, is as follows:]

 [(i)    at the end of one year from the date of  grant,  up to 25% of the total
         shares subject to the option;

 (ii)    at the end of the second year from the date of grant, up to 50%;

 (iii)   at the end of the third year from the date of grant, up to 75%;

 (iv)    at the end of the fourth year from the date of grant, up to 100%.]

This  option may not be  exercised  for less than ten shares at any one time (or
the remaining  shares then  purchasable if less than ten) and expires at the end
of  ________  years  [insert  number of years;  maximum up ten] from the date of
grant  whether  or not it has been  duly  exercised  (hereinafter,  the  "Option
Expiration Date"),  unless sooner terminated as provided in paragraphs 5, 6 or 7
hereof.


                  4.       How Option May Be Exercised.

                  This option is  exercisable  by a written notice signed by you
and delivered to the Company at its executive offices,  signifying your election
to  exercise  the  option.  The notice must state the number of shares of Common
Stock as to which your option is being  exercised,  must  contain a statement by
you (in a form acceptable to the Company) that such shares are being acquired by
you for investment and not with a view to their distribution or resale (unless a
Registration  Statement  covering  the  shares  purchasable  has  been  declared
effective by the Securities and Exchange  Commission) and must be accompanied by
cash or a check to the order of the Company for the full  purchase  price of the
shares being purchased [if "cashless  exercise" is permitted,  add the following
phrase:]  [, unless  exercised  pursuant to the  following  "cashless  exercise"
provision.]

         [Insert the following "cashless exercise" provision,  if granted by the
Committee:] [In lieu of paying for the shares  purchasable  under this option by
cash or check, you may (i) deliver  previously owned shares of Common Stock with
a fair  market  value  equal to the full  purchase  price  of the  shares  being
purchased under this option, or (ii) request that the Company withhold shares of
Common  Stock  issuable  upon  exercise of this option with a fair market  value
equal to the full purchase price of the shares being purchased under this option
(thereby  reducing the number of shares  issuable upon exercise of this option).
For purposes of this option,  unless the  Committee  determines  otherwise,  the
"fair market value" of a share of Common Stock as of a certain date shall be the
closing  sale price of the Common  Stock on The Nasdaq  Stock  Market or, if the
Common  Stock is not then  traded on The  Nasdaq  Stock  Market,  such  national
securities  exchange on which the Common  Stock is then  traded,  on the trading
date immediately  preceding the date fair market value is being determined.  The
Committee may make such other determination of fair market value, based on other
factors, as it shall deem appropriate.]

                  If notice of the  exercise of this option is given by a person
or persons  other than you,  the Company  may  require,  as a  condition  to the
exercise of this option,  the submission to the Company of appropriate  proof of
the right of such person or persons to exercise this option.

                  Certificates  for shares of the Common Stock so purchased will
be issued as soon as practicable. The Company, however, shall not be required to
issue or deliver a  certificate  for any shares until it has  complied  with all
requirements of the Securities Act of 1933, the Securities Exchange Act of 1934,
any stock  exchange on which the  Company's  Common Stock may then be listed and
all applicable state laws in connection with the issuance or sale of such shares
or the  listing  of such  shares on said  exchange.  Until the  issuance  of the
certification  for such  shares,  you or such other person as may be entitled to
exercise this option shall have none of the rights of a stockholder with respect
to shares subject to this option.

                  The Company shall have the right to require you, or such other
person as may be permitted to exercise  this option,  to remit to the Company an
amount   sufficient  to  satisfy  federal,   state  and  local  withholding  tax
requirements prior to the delivery of any certificate or certificates for shares
of Common Stock issuable upon exercise of this option.

                  5.       Termination of Employment.

                  If your employment with the Company (or a subsidiary  thereof)
is  terminated  for any  reason  other  than by  death  or  disability,  you may
exercise, within three months from the date of such termination, that portion of
the  option  which  was  exercisable  by you at the  date of  such  termination,
provided, however, that such exercise occurs no later than the Option Expiration
Date.

                  6.       Disability.

                  If your employment with the Company (or a subsidiary  thereof)
is terminated  by reason of your  disability,  you may  exercise,  within twelve
months from the date of such termination,  that portion of this option which was
exercisable by you at the date of such termination, provided, however, that such
exercise occurs no later than the Option Expiration Date.

                  7.       Death.

                  If you die while  employed  by the  Company  (or a  subsidiary
thereof)  or within six  months  after  termination  of your  employment  due to
disability, that portion of this option which was exercisable by you at the date
of your death may be exercised by your legatee or legatees  under your Will,  or
by your personal representatives or distributees,  within twelve months from the
date of your death, but in no event after the Option Expiration Date.

                  8.       Non-Transferability of Option.

                  This option  shall not be  transferable  except by Will or the
laws of descent and distribution, and may be exercised during your lifetime only
by you.

                  9.       Adjustments upon Changes in Capitalization.

                  If at any time  after  the date of grant of this  option,  the
Company shall, by stock dividend,  split-up,  combination,  reclassification  or
exchange, or through merger or consolidation, or otherwise, change its shares of
Common  Stock  into a  different  number  or kind or  class of  shares  or other
securities or property, then the number of shares covered by this option and the
price of each such share shall be  proportionately  adjusted for any such change
by the Committee, whose determination shall be conclusive.

                  10.     Acceleration of Exercisability Upon Change in Control.

                  Upon the  occurrence  of a "change in  control" of the Company
(as defined below), this option shall become immediately fully exercisable.  For
purposes of this option, a "change in control" of the Company shall mean (i) the
acquisition  at any  time by a  "person"  or  "group"  (as such  terms  are used
Sections  13(d) and  14(d)(2) of the Exchange Act of  beneficial  ownership  (as
defined in Rule 13d-3  under the  Exchange  Act),  directly  or  indirectly,  of
securities representing 50% or more of the combined voting power in the election
of directors of the then outstanding  securities of the Company or any successor
or the Company;  (ii) the  termination  of service of directors,  for any reason
other than death,  disability or retirement from the Board of Directors,  during
any period of two consecutive years or less, of individuals who at the beginning
of such  period  constituted  a majority of the Board of  Directors,  unless the
election of or nomination  for election of each new director  during such period
was approved by a vote of at least  two-thirds of the directors  still in office
who were  directors  at the  beginning  of the  period;  (iii)  approval  by the
stockholders  of the Company of any merger,  consolidation,  or statutory  share
exchange as a result of which the Common  Stock shall be changed,  converted  or
exchanged  (other  than  a  merger,  consolidation  or  share  exchange  with  a
wholly-owned   Subsidiary)  or  liquidation  of  the  Company  or  any  sale  or
disposition  of 80% or more of the assets or earning  power or the  Company;  or
(iv) approval by the  stockholders of the Company of any merger,  consolidation,
or statutory share exchange to which the Company is a party as a result of which
the persons who were stockholders immediately prior to the effective date of the
merger,  consolidation or share exchange shall have beneficial ownership of less
than 50% of the  combined  voting  power in the  election  of  directors  of the
surviving  corporation;  provided,  however,  that no change in control shall be
deemed to have  occurred  if,  prior to such time as a change in  control  would
otherwise be deemed to have  occurred,  the Company's  Board of Directors  deems
otherwise.
                  11.      Subject to Terms of the Plan.

                  This incentive stock option  agreement shall be subject in all
respects  to the  terms  and  conditions  of the  Plan  and in the  event of any
question or  controversy  relating to the terms of the Plan, the decision of the
Committee shall be conclusive.

                                Sincerely yours,

                                                     VIMRx PHARMACEUTICALS INC.



                                                     By:
                                      Name:
                                     Title:


Agreed to and accepted this
      day of          , 199 .



Signature of Optionee


<PAGE>








                                                          EXHIBIT B TO 1990 PLAN

                           VIMRx PHARMACEUTICALS INC.

                      NON-INCENTIVE STOCK OPTION AGREEMENT

                     ---------------------------------------

To:

                  We are pleased to notify you that by the  determination of the
Stock Option Plan  Committee  (herein called the  "Committee")  a  non-incentive
stock  option to purchase  shares of the Common  Stock of VIMRx  Pharmaceuticals
Inc. (herein called the "Company") at a price of $ per share has this day of
                 been  granted to you under the  Company's  1990  Incentive  and
Non-Incentive  Stock Option Plan (herein called the "Plan").  This option may be
exercised only upon the terms and conditions set forth below.



<PAGE>





                  1.       Purpose of Option.

                  The purpose of the Plan under which this  non-incentive  stock
option has been granted is to further the growth and  development of the Company
and its  subsidiaries  by  encouraging  key employees,  directors,  consultants,
agents,  independent  contractors  and  other  persons  who  contribute  and are
expected  to  contribute  materially  to  the  Company's  success  to  obtain  a
proprietary  interest in the Company  through the  ownership  of stock,  thereby
providing such persons with an added  incentive to promote the best interests of
the Company,  and  affording  the Company a means of  attracting  to its service
persons of outstanding ability.

                  2.       Acceptance of Option Agreement.

                  Your execution of this  non-incentive  stock option  agreement
will indicate your acceptance of and your  willingness to be bound by its terms;
it imposes no obligation  upon you to purchase any of the shares subject to this
option.  Your obligation to purchase shares can arise only upon your exercise of
the option in the manner set forth in paragraph 4 hereof.

                  3.       When Option May Be Exercised.

                  The option  granted  you  hereunder  shall be  exercisable  as
follows:  [set forth terms and expiration date of Option,  but in no event shall
the Option be exercisable until at least six months from the date of grant].

                  This option may not be  exercised  for less than ten shares at
any one time (or the  remaining  shares then  purchasable  if less than ten) and
expires at the end of ________  years [insert  number of years;  maximum up ten]
from the date of grant whether or not it has been duly  exercised  (hereinafter,
the  "Option  Expiration  Date"),   unless  sooner  terminated  as  provided  in
paragraphs 5, 6 or 7 hereof.

                  4.       How Option May Be Exercised.

                  This option is  exercisable  by a written notice signed by you
and delivered to the Company at its executive offices,  signifying your election
to  exercise  the  option.  The notice must state the number of shares of Common
Stock as to which your option is being  exercised,  must  contain a statement by
you (in a form acceptable to the Company) that such shares are being acquired by
you for investment and not with a view to their distribution or resale (unless a
Registration Statement covering the shares purchased has been declared effective
by the Securities and Exchange  Commission) and must be accompanied by cash or a
check to the order of the  Company  for the full  purchase  price of the  shares
being purchased, plus such amount, if any, as is required for withholding taxes.
[If   "cashless   exercise"   is   permitted,   add   the   following   phrase:]
[Notwithstanding  the foregoing,  this option may also be exercised  pursuant to
the following "cashless exercise" provision.]

         [Insert the following "cashless exercise" provision,  if granted by the
Committee:] [In lieu of paying for the shares  purchasable  under this option by
cash or check, you may (i) deliver  previously owned shares of Common Stock with
a fair  market  value  equal to the full  purchase  price  of the  shares  being
purchased under this option, or (ii) request that the Company withhold shares of
Common  Stock  issuable  upon  exercise of this option with a fair market  value
equal to the full purchase price of the shares being purchased under this option
(thereby  reducing the number of shares  issuable upon exercise of this option).
For purposes of this option,  unless the  Committee  determines  otherwise,  the
"fair market value" of a share of Common Stock as of a certain date shall be the
closing  sale price of the Common  Stock on The Nasdaq  Stock  Market or, if the
Common  Stock is not then  traded on The  Nasdaq  Stock  Market,  such  national
securities  exchange on which the Common  Stock is then  traded,  on the trading
date immediately  preceding the date fair market value is being determined.  The
Committee may make such other determination of fair market value, based on other
factors, as it shall deem appropriate.] .
                  If notice of the  exercise of this option is given by a person
or persons  other than you,  the Company  may  require,  as a  condition  to the
exercise of this option,  the submission to the Company of appropriate  proof of
the right of such person or persons to exercise this option.

                  Certificates  for shares of the Common Stock so purchased will
be issued as soon as practicable. The Company, however, shall not be required to
issue or deliver a  certificate  for any shares until it has  complied  with all
requirements of the Securities Act of 1933, the Securities Exchange Act of 1934,
any stock  exchange on which the  Company's  Common Stock may then be listed and
all applicable state laws in connection with the issuance or sale of such shares
or the  listing  of such  shares on said  exchange.  Until the  issuance  of the
certificate  for such  shares,  you or such other  person as may be  entitled to
exercise this option shall have none of the rights of a stockholder with respect
to shares subject to this option.

                  The Company shall have the right to require you, or such other
person as may be permitted to exercise  this option,  to remit to the Company an
amount   sufficient  to  satisfy  federal,   state  and  local  withholding  tax
requirements prior to the delivery of any certificate or certificates for shares
of Common Stock issuable upon exercise of this option.

                  5.        Termination of Employment or Engagement.

                  [The Committee may determine to delete this provision,  at the
time of grant or by  amendment,  to  non-employees,  in which  event  the  words
"Intentionally omitted" should be inserted.] If your employment with the Company
(or a subsidiary  thereof) is  terminated  for any reason other than by death or
disability,  or if a you are not an employee of the Company and your  engagement
by the Company (or a subsidiary) is terminated for any reason, you may exercise,
within  three  months from the date of such  termination,  that  portion of this
option which was exercisable by you at the date of such  termination,  provided,
however, that such exercise occurs prior to the Option Expiration Date.

                  6.       Disability.

                  If your employment with the Company (or a subsidiary  thereof)
is terminated  by reason of your  disability,  you may  exercise,  within twelve
months from the date of such termination,  that portion of this option which was
exercisable by you at the date of such termination, provided, however, that such
exercise occurs prior to the Option Expiration Date.

                  7.       Death.

                  If you die while  employed  by the  Company  (or a  subsidiary
thereof)  or within six  months  after  termination  of your  employment  due to
disability, that portion of this option which was exercisable by you at the date
of your death may be exercised by your legatee or legatees  under your Will,  or
by your personal representatives or distributees,  within twelve months from the
date of your death, but in no event after the Option Expiration Date.

                  8.       Non-Transferability of Option.

                  This option  shall not be  transferable  except by Will or the
laws of descent and distribution, and may be exercised during your lifetime only
by you.

[Alternative Section 8, if provided for by the Committee:]

                  [8.      Limited Transferability of Option.

                  This  option  shall not be  transferable  except to members of
your family or to your family  trust(s),  and by Will or the laws of descent and
distribution.]

                  9.       Adjustments upon Changes in Capitalization.

                  If at any time  after  the date of grant of this  option,  the
Company shall, by stock dividend,  split-up,  combination,  reclassification  or
exchange, or through merger or consolidation, or otherwise, change its shares of
Common  Stock  into a  different  number  or kind or  class of  shares  or other
securities or property, then the number of shares covered by this option and the
price of each such share shall be  proportionately  adjusted for any such change
by the Committee, whose determination shall be conclusive.

                  10.     Acceleration of Exercisability Upon Change in Control.

                  Upon the  occurrence  of a "change in  control" of the Company
(as defined below), this option shall become immediately fully exercisable.  For
purposes of this option, a "change in control" of the Company shall mean (i) the
acquisition  at any  time by a  "person"  or  "group"  (as such  terms  are used
Sections  13(d) and  14(d)(2) of the Exchange Act of  beneficial  ownership  (as
defined in Rule 13d-3  under the  Exchange  Act),  directly  or  indirectly,  of
securities representing 50% or more of the combined voting power in the election
of directors of the then outstanding  securities of the Company or any successor
or the Company;  (ii) the  termination  of service of directors,  for any reason
other than death,  disability or retirement from the Board of Directors,  during
any period of two consecutive years or less, of individuals who at the beginning
of such  period  constituted  a majority of the Board of  Directors,  unless the
election of or nomination  for election of each new director  during such period
was approved by a vote of at least  two-thirds of the directors  still in office
who were  directors  at the  beginning  of the  period;  (iii)  approval  by the
stockholders  of the Company of any merger,  consolidation,  or statutory  share
exchange as a result of which the Common  Stock shall be changed,  converted  or
exchanged  (other  than  a  merger,  consolidation  or  share  exchange  with  a
wholly-owned   Subsidiary)  or  liquidation  of  the  Company  or  any  sale  or
disposition  of 80% or more of the assets or earning  power or the  Company;  or
(iv) approval by the  stockholders of the Company of any merger,  consolidation,
or statutory share exchange to which the Company is a party as a result of which
the persons who were stockholders immediately prior to the effective date of the
merger,  consolidation or share exchange shall have beneficial ownership of less
than 50% of the  combined  voting  power in the  election  of  directors  of the
surviving  corporation;  provided,  however,  that no change in control shall be
deemed to have  occurred  if,  prior to such time as a change in  control  would
otherwise be deemed to have  occurred,  the Company's  Board of Directors  deems
otherwise.

                  11.      Subject to Terms of the Plan.

                  This non-incentive  stock option agreement shall be subject in
all  respects  to the terms and  conditions  of the Plan and in the event of any
question or  controversy  relating to the terms of the Plan, the decision of the
Committee shall be conclusive.

                  12.      Tax Status.

                  This option does not qualify as an  "incentive  stock  option"
under the  provisions  of Section 422A of the Internal  Revenue Code of 1986, as
amended,  and the income tax  implications  of your  receipt of a  non-incentive
stock option and your exercise of such an option  should be discussed  with your
tax counsel.

                                Sincerely yours,

                                                     VIMRx PHARMACEUTICALS INC.


                                                     By:
                                      Name:
                                     Title:

Agreed to and accepted this
     day of          , 199 .


Signature of Optionee



                                  


PROXY
                           VIMRX PHARMACEUTICALS INC.


        THIS PROXY IS BEING SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

         The  undersigned  hereby  appoints  Donald G. Drapkin and Eric A. Rose,
M.D., and each of them,  proxies,  each with the power of substitution,  to vote
the shares of the  undersigned  at the Annual Meeting of  Stockholders  of VIMRX
Pharmaceuticals  Inc. on June 24, 1997, and any adjournments  and  postponements
thereof,  upon all  matters as may  properly  come before the  Meeting.  Without
otherwise  limiting  the  foregoing  general  authorization,   the  proxies  are
instructed to vote as indicated herein.

                Please  complete,  date and sign on the reverse side and mail in
the enclosed envelope.

THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR MATTERS (1), (2), (3), (4) and (5)
 LISTED BELOW, TO COME BEFORE THE MEETING:
(1) Election of eight (8) directors:              Nominees:   Donald G. Drapkin,
                                                             Richard L. Dunning,
                                                             Eric A. Rose, M.D.,
                                                               Lawrence D. Fink,
                                                          Jerome Groopman, M.D.,
                                                              Linda G. Robinson,
                                                     Lindsay A. Rosenwald, M.D.,
                                                            Michael Weiner, M.D.
                              [ ] FOR [ ] WITHHELD

                For, except withheld from the following nominees:






(2) To approve the amendment of the Company's 1990 Incentive and Non-Incentive  
    Stock Option Plan to read as set forth in Exhibit A.

                        [ ] FOR [ ] WITHHELD [ ] ABSTAIN

(3) To approve the adoption of Company's 1997 Incentive and Non-Incentive  Stock
Option Plan.

                        [ ] FOR [ ] WITHHELD [ ] ABSTAIN

(4) To ratify the  appointment of KPMG Peat Marwick LLP as independent  auditors
    of the Company for the year ending December 31, 1997.
                        [ ] FOR [ ] WITHHELD [ ] ABSTAIN
(5) Upon any and all other business that may come before the Meeting.

    Check here if you plan to attend the Annual Meeting of Stockholders.   [   ]

This  Proxy,  which is  solicited  on behalf of the Board of  Directors, will be
voted FOR the matters  described  in paragraphs  (1),  (2),  (3), and (4) unless
the  stockholder  specifies  otherwise,  in which case it will be voted as
specified.
SIGNATURE(S):                                                           DATE:
Note: Executors, Administrations, Trustees, Etc. should give full
title.




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