VIMRX PHARMACEUTICALS INC
8-K, 1997-01-03
PHARMACEUTICAL PREPARATIONS
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<PAGE>


                                                        

                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549


                           ___________________________

                                    FORM 8-K

                                 CURRENT REPORT


                     PURSUANT TO SECTION 13 OR 15(d) of the

                         SECURITIES EXCHANGE ACT OF 1934


       Date of Report (Date of earliest event reported): December 23, 1996


                           VIMRx Pharmaceuticals Inc.
               (Exact name of registrant as specified in charter)


        Delaware                   0-19153                     06-1192468
  (State or other juris-         (Commission                 (IRS Employer
    diction of incorp-           File Number)             Identification No.)
         oration)


  2751 Centerville Road, Wilmington, Delaware                     19808
    (Address of principal executive offices)                     (Zip code)


       Registrant's telephone number, including area code: (302) 998-1734


                1200 High Ridge Road, Stamford, Connecticut 06905
          (Former name or former address, if changed since last report)



 




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<PAGE>

 
Item 2. Acquisition or Disposition of Assets.
 
     On  December  23,  1996,  VIMRx  Pharmaceuticals  Inc.  (the  "Registrant")
acquired an approximate  68% ownership  interest in Innovir  Laboratories,  Inc.
(Nasdaq SmallCap: INVR) ("Innovir"), pursuant to an agreement dated November 21,
1996, as amended, among the Registrant and The Aries Fund, a Cayman Island trust
(the "Aries  Trust"),  and The Aries  Domestic  Fund,  L.P., a Delaware  limited
partnership ("The Aries Limited Partnership" and, together with the Aries Trust,
the "Aries  Funds"),  and an  agreement  dated  November  21,  1996  between the
Registrant and Innovir.
 
     Pursuant to the agreements,  as amended (i) the Aries Funds,  which owned 4
million  shares of Innovir's  common stock prior to the  transaction,  exercised
warrants and unit purchase  options to purchase an additional 6 million  shares,
thereby providing $3 million in cash to Innovir and resulting in the Aries Funds
owning 10 million shares of Innovir's common stock; (ii) the Registrant acquired
9.5 million shares of Innovir's common stock from the Aries Funds for $3,000,000
in cash and  3,000,000  newly  issued  shares (the  "Registrant  Shares") of the
Common  Stock,  $.001 par value,  of the  Registrant,  and (iii) the  Registrant
exchanged  all of  the  capital  stock  of its  wholly-owned  subsidiary,  VIMRx
Holdings Ltd., a Delaware  corporation ("VHL") (to which, prior to closing,  the
Registrant  had made a capital  contribution  of  $4,000,000),  for 8.7  million
shares of Innovir's  convertible  preferred stock  (convertible into 8.7 million
shares of  Innovir's  common  stock),  plus  five-year  warrants  to purchase an
additional 2 million  shares of Innovir's  common stock (1 million  shares at an
exercise  price of $1.00 per share and 1 million  shares at an exercise price of
$2.00 per share).
 
     The  Registrant   has  agreed  to  file  a   registration   statement  (the
"Registration  Statement")  with the  Securities  and Exchange  Commission  (the
"Commission")  by  February  6, 1997 for the  public  resale  of the  Registrant
Shares,  to use its best  efforts  to cause  the  Registration  Statement  to be
declared  effective  by the  Commission  under  the  Securities  Act as  soon as
practicable  and to use its  best  efforts  to keep the  Registration  Statement
effective  until the earlier of the date the  Registrant  Shares shall have been
disposed of or the date on which all  Registrant  Shares are  eligible  for sale
pursuant to Rule 144 under the  Securities Act (December 23, 1999 under Rule 144
as in effect on the date of this  Report).  The Company has agreed to  indemnify
the  holders  of  the  Registrant  Shares  against  certain  civil  liabilities,
including liabilities under the Securities Act.
<PAGE>
 
     Lindsay  A.  Rosenwald,  M.D.,  a  director  of the  Registrant,  serves as
President and is sole shareholder of the investment  manager of the Aries Trust,
and serves as President and is the sole  shareholder  of the general  partner of
the  Aries  Limited  Partnership.  Jerome  Groopman,  M.D.,  a  director  of the
Registrant,  is an interested  party in the Aries Funds.  The acquisition of the
9.5 million shares of Innovir stock from the Aries Funds was negotiated at arms'
length  with the  Aries  Funds  and an  opinion  was  issued  by an  independent
investment  banking firm that the transaction was fair from a financial point of
view to the Registrant and its public shareholders.
 
     Innovir has agreed to convene a meeting of its  stockholders to elect seven
directors,  four of whom  shall  be  designees  of the  Registrant  (Richard  L.
Dunning,  the  Registrant's  President and Chief Executive  Officer,  Francis M.
O'Connell,  the  Registrant's  Chief Financial  Officer,  David A. Jackson,  the
Registrant's Executive Vice President and Chief Scientific Officer, and Laurence
D. Fink,  a director  of the  Registrant),  and to approve an  amendment  to its
certificate  of  incorporation  to increase the  authorized  number of shares of
Innovir's common stock to 70,000,000 shares.
 
     Under  the  agreements,  (i) the  Registrant  has  agreed to  exercise  its
warrants to purchase 1 million  shares of  Innovir's  common  stock at $1.00 per
share (for an aggregate exercise price of $1 million) after receipt of a written
request from Innovir's Board of Directors  subsequent to May 31, 1997 specifying
that Innovir has insufficient  funds to continue its operations,  (ii) the Aries
Funds have agreed to exercise warrants to purchase 2 million shares of Innovir's
common stock at $.50 per share (for an aggregate  exercise  price of $1 million)
in the event the Registrant  exercises its warrants pursuant to clause (i) above
and to grant VIMRx an  irrevocable  voting proxy through  November 31, 1999 with
respect to the shares of common stock so purchased  (which will not restrict the
Aries Funds from  selling  such  shares and will lapse with  respect to any such
shares  sold),  and (iii) the Aries Funds granted  VIMRx an  irrevocable  voting
proxy with respect to the 500,000 shares of Innovir's  common stock owned by the
Aries Funds  (which will not  restrict  the Aries Funds from selling such shares
and will lapse with respect to any such shares sold).
 
     VHL and Innovir are each  engaged in  developing  therapeutic  technologies
that seek to control disease-triggering flaws in individuals' genetic chemistry.
VHL's  and  Innovir's  technologies  are  each  based  on a  different  class of
catalytically  active  oligomers  (referred to by Innovir and the  Registrant as
"OligozymesTM") that have shown an ability to inactivate certain RNA "messenger"
molecules  that  direct  cells  to  produce  illness-causing   proteins.   VHL's
technology focuses on RILONTM OligozymesTM,  and Innovir's technology focuses on
External Guidance Sequence ("EGS") OligozymesTM.


                                       3
<PAGE>


Item 7. Financial Statements, Pro Forma Financial Information and Exhibits.
 
     (a) Financial Statements of Businesses Acquired.
 
     It is  impracticable to provide the required  financial  statements for the
acquired  business  at the date of  filing  of this  Form  8-K.  Such  financial
statements  will be filed  as soon as  practicable,  but no  later  than 60 days
following the date this Form 8-K is required to be filed.
 
 
     (c) Exhibits.
 
     2.2a Agreement dated November 21, 1996 (the "Aries Agreement") by and among
          the Registrant and The Aries Fund and The Aries Domestic Fund, L.P.
 
     2.2b Amendment to the Aries  Agreement dated December 23, 1996 by and among
          the Registrant and the Aries Fund and The Aries Domestic Fund, L.P.

     2.3  Agreement  dated  November 21, 1996 by and between the  Registrant and
          Innovir Laboratories, Inc.

     10.17Registration  Rights  Agreement  dated  December 23, 1996 by and among
          the Registrant and The Aries Fund and The Aries Domestic Fund, L.P.





                                       4
<PAGE>

                                    SIGNATURE
 
 
     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.
 
                                            VIMRx PHARMACEUTICALS INC.
                                               (Registrant)
 
 
                                            By: /s/ Francis M. O'Connell
                         
                                                    Francis M. O'Connell
                                                    Chief Financial Officer
 
         Dated:  December 30, 1996



                                       5
<PAGE>

                                  EXHIBIT INDEX
 
                                                                   Page

2.2a Agreement dated November 21, 1996 (the "Aries Agreement"), by and among the
     Registrant   and  The   Aries   Fund   and   The   Aries   Domestic   Fund,
     L.P........................................................... 7

2.2b Amendment to the Aries  Agreement  dated December 23, 1996 by and among the
     Registrant   and  the   Aries   Fund   and   The   Aries   Domestic   Fund,
     L.P........................................................... 23

2.3  Agreement dated November 21, 1996 by and between the Registrant and Innovir
     Laboratories, Inc. ............................................25

10.17Registration  Rights  Agreement  dated  December  23, 1996 by and among the
     Registrant   and  The   Aries   Fund   and   The   Aries   Domestic   Fund,
     L.P........................................................... 54



                                       6
<PAGE>

 
 
                                                                 Exhibit 2.2a
 
 
 
                                    AGREEMENT


                                  by and among


                           VIMRx PHARMACEUTICALS INC.


                                       and


                                 THE ARIES FUND

                                       and

                          THE ARIES DOMESTIC FUND, L.P.









                                               Dated: November 21, 1996



                                       7
<PAGE>



                                TABLE OF CONTENTS

                                                                      Page


AGREEMENT.............................................................  1

RECITALS..............................................................  1

ARTICLE 1         EXCHANGE OF SHARES..................................  1
 
         1.1      Exchange of Shares..................................  1
         1.2      Adjustment of Initial VIMRx Shares..................  1

ARTICLE 2         REPRESENTATIONS AND WARRANTIES OF VIMRx.............  2 
         2.1      Organization........................................  2
         2.2      Authority and Consent...............................  2
         2.3      The VIMRx Shares....................................  3
         2.4      Investment Purposes.................................  3
         2.5      Documents Delivered.................................  3
         2.6      No Breach...........................................  3
         2.7      Litigation..........................................  3
         2.8      Disclosure..........................................  4
 
ARTICLE 2         REPRESENTATIONS AND WARRANTIES OF ARIES.............  4
 
         3.1      Organization........................................  4
         3.2      Authority and Consent...............................  4
         3.3      The Innovir Shares..................................  4
         3.4      Examination of Documents, Investment Purposes and
                  Legending of the VIMRx Shares.......................  4
         3.5      Ownership of VIMRx Common Stock ....................  5

ARTICLE 4  COVENANTS OF VIMRx AND THE ARIES FUNDS.....................  5
 
         4.1      Further Assurances..................................  5
         4.2      Filings and Consents................................  5
         4.3      Access to Information and Confidentiality...........  5

ARTICLE 5         ADDITIONAL COVENANT OF THE ARIES FUNDS..............  6
 
         5.1      Additional Covenant of The Aries Funds..............  6

                                       8
<PAGE>


 
ARTICLE 6         CONDITIONS TO CLOSING...............................  6

         6.1      Conditions to Obligations of The Aries Funds........  6
         6.2      Conditions to Obligations of VIMRx..................  7

ARTICLE 7         CLOSING.............................................  8
 
         7.1      Closing Date........................................  8
         7.2      Deliveries by VIMRx.................................  8
         7.3      Deliveries by The Aries Funds.......................  8

ARTICLE 8         SURVIVAL............................................  9
 
         8.1      Survival............................................  9

ARTICLE 9         INDEMNIFICATION.....................................  9
 
         9.1      Indemnification.....................................  9

ARTICLE 10  MISCELLANEOUS PROVISIONS ................................. 10
 

         10.1     Amendment and Modification.......................... 10
         10.2     Waiver of Compliance................................ 10
         10.3     Expenses............................................ 10
         10.4     Notices............................................. 10
         10.5     Assignment.......................................... 11
         10.6     Freedom of Action................................... 11
         10.7     Third Parties....................................... 12
         10.8     Governing Law....................................... 12
         10.9     Counterparts........................................ 12
         10.10   Headings............................................. 12
         10.11   Entire Agreement..................................... 12




                                       9
<PAGE>




                                    AGREEMENT


     AGREEMENT  (the  "Agreement")  made this 21st day of November,  1996 by and
among  VIMRx  Pharmaceuticals  Inc.,  a  Delaware  corporation  ("VIMRx"  or the
"Company"),  The Aries Fund,  A Cayman  Island  Trust  ("Aries I") and The Aries
Domestic Fund, L.P. , a Delaware limited  partnership  ("Aries II" and, together
with Aries I, "The Aries Funds").

                                 R E C I T A L S

     WHEREAS,  The Aries  Funds own  4,000,000  shares  of the  Common  Stock of
Innovir Laboratories, Inc., a Delaware corporation ("Innovir") and hold warrants
to purchase an  additional  8,000,000  shares of  Innovir's  Common  Stock at an
aggregate exercise price of $4,000,000; and

     WHEREAS,  The  Aries  Funds  have  indicated,  subject  to  the  terms  and
conditions of this Agreement,  that they will exercise certain of such warrants,
thereby purchasing 6,000,000 shares of Innovir's Common Stock; and

     WHEREAS,  VIMRx is desirous of  exchanging  shares of its Common  Stock for
9,500,000 of the 10,000,000  shares of Innovir's Common Stock to be owned by The
Aries Funds  following  the  exercise by The Aries Funds of their  warrants,  as
aforesaid,  and The Aries Funds are desirous of  effecting  such  exchange  (the
9,500,000  shares of  Innovir's  Common Stock to be so  exchanged,  the "Innovir
Shares").

     NOW, THEREFORE, VIMRx and The Aries Funds hereby agree as follows:

                                    ARTICLE 1

                               EXCHANGE OF SHARES

     1.1  Exchange  of  shares.  Subject  to the  terms and  conditions  of this
Agreement and in reliance  upon the  representations,  warranties  and covenants
herein contained,  on the date of closing specified in Section 7.1 (the "Closing
Date"), The Aries Funds hereby agree to assign, transfer and deliver the Innovir
Shares to VIMRx or its designee and, in exchange  therefor,  VIMRx hereby agrees
to issue and  deliver to The Aries  Funds,  pro rata to their  ownership  of the
Innovir  Shares to be delivered,  2,750,000  shares of VIMRx's Common Stock (the
"Initial  VIMRx  Shares"),  subject to  adjustment  as set forth in Section  1.2
hereof  (the  number of shares of VIMRx's  Common  Stock  issued  following  all
adjustments, the "VIMRx Shares").

     1.2 Adjustment of Initial VIMRx Shares.   The Initial VIMRx Shares shall be
subject to  adjustment  on or about  January 22, 1997 and on or about January 7,
1998, as follows:

     (a) On or about January 22, 1997, but no later than January 30, 1997, VIMRx
shall  issue to The Aries  Funds  such  additional  number of shares of  VIMRx's
Common Stock, if any, as shall be determined by (i) dividing  $12,350,000 by the
average of the Daily  Prices (as defined  below) for each trading day of VIMRx's
Common  Stock during the period from  November 15, 1996 to January 15, 1997,  as
reported  by The Nasdaq  Stock  Market,  and (ii)  deducting  from the number of
shares so determined  the Initial VIMRx Shares (the Initial VIMRx Shares and the
additional  shares of VIMRx's Common Stock,  if any, so issued,  the "Base VIMRx
Shares" and the per share value  determined by dividing  $12,350,000 by the Base
VIMRx Shares, the "Base VIMRx Per Share Value").  Notwithstanding the foregoing,
in no event shall the Base VIMRx Shares be less than the Initial VIMRX shares.

                                       10
<PAGE>

     (b) In the event the  average of the Daily  Prices for each  trading day of
VIMRx's  Common  Stock  during the period from  November 1, 1997 to December 31,
1997,  as reported by The Nasdaq Stock Market (the  "December 31, 1997 Per Share
Average  Value") is lower than the Base VIMRx Per Share Value then,  on or about
January 7, 1998,  but no later than January 15,  1998,  VIMRx shall issue to The
Aries Funds such  additional  number of shares of VIMRx's Common Stock, as shall
be determined by (i)  multiplying  the number of shares of VIMRx's  Common Stock
owned by The Aries Funds on December 31, 1997 (such number of shares, "The Aries
Funds December 31, 1997 VIMRx Holdings") by the Base VIMRx Per Share Value, (ii)
subtracting  from the  amount so  obtained  an amount  equal to The Aries  Funds
December 31, 1997 VIMRx  Holdings  multiplied by the December 31, 1997 Per Share
Average Value, and (iii) dividing the difference so obtained by the December 31,
1997 Per Share Average Value;  provided,  however, that no such adjustment shall
be made in the event the total  proceeds  received by The Aries Funds from their
sales of VIMRx's  Common Stock prior to December 31, 1997,  plus The Aries Funds
December 31, 1997 VIMRx  Holdings  multiplied by the December 31, 1997 Per Share
Average Value equals or exceeds $12,350,000. For purposes of this Agreement, the
"Daily  Price"  shall be, for each  trading day in the  applicable  period,  the
average of the bid and asked price of VIMRX's Common Stock for such day.


                                    ARTICLE 2

                     REPRESENTATIONS AND WARRANTIES OF VIMRx

                  VIMRx represents and warrants to The Aries Funds that:

     2.1 Organization.  VIMRx is a corporation duly organized,  validly existing
and in good standing under the laws of the State of Delaware,  has all requisite
corporate power and authority to own, lease and operate its properties and carry
on its business as now conducted, and is duly qualified as a foreign corporation
in each  jurisdiction  in which it is required to be so qualified,  except where
the  failure  to  qualify  would  not  have a  material  adverse  effect  on its
operations.

     2.2 Authority  and  Consent.  This  Agreement  has been duly  executed and
delivered  by VIMRx and is a valid and binding  agreement  of VIMRx  enforceable
against  VIMRx in  accordance  with  its  terms,  except  as may be  limited  by
applicable  bankruptcy,  insolvency or similar laws affecting  creditors' rights
generally or the  availability of equitable  remedies and no consent or approval
is required of any governmental  authority,  person,  corporation,  partnership,
trust or other entity of any kind  ("Person") in connection with the performance
by VIMRx of this Agreement or the transactions contemplated hereby.

                                       11
<PAGE>

     2.3 The VIMRx Shares. The VIMRx Shares to be delivered hereby,  when issued
in accordance  with the terms of this Agreement,  will be validly issued,  fully
paid and  non-assessable,  free and clear of all liens imposed by or through the
Company,  and will not be subject to any preemptive right of stockholders of the
Company or to any right of first refusal or other right in favor of any person.

     2.4 Investment Purposes.  VIMRx is acquiring the Innovir Shares for its own
account for investment  within the  contemplation of the Securities Act of 1933,
as amended (the "Securities  Act") and not with a view to the transfer or resale
thereof.

    2.5 Documents Delivered. VIMRx has delivered to The Aries Funds VIMRx's (i)
Annual  Report on Form 10-K for its fiscal  year ended  December  31,  1995 (ii)
Quarterly  Reports on Form 10-Q for the quarters ended March 31, 1996,  June 30,
1996 and  September  30,  1996 and (iii)  Proxy  Statement  for its 1996  Annual
Meeting of Stockholders (collectively,  the "SEC Documents"). The SEC Documents,
including the financial  statements  included therein,  complied as to form with
the  requirements  of the  Securities  Exchange Act of 1934,  as amended and the
rules  and  regulations  thereunder,  were  true and  complete  in all  material
respects as at their respective  dates, and did not contain any untrue statement
of a material  fact nor omit to state any  material  fact  required to be stated
therein or necessary to make the statements  contained therein,  in light of the
circumstances  under  which  they were  made,  not  misleading  and no event has
occurred since September 30, 1996 which would have a material  adverse effect on
the operations, financial condition or results of operations of VIMRx.

     2.6 No Breach. The execution and delivery by the Company of this Agreement,
the issuance of the VIMRx Shares  hereunder and the  performance and fulfillment
by the Company of its  obligations  hereunder  do not and will not (i)  conflict
with or result in a breach of the  terms,  conditions  or  provisions  of,  (ii)
constitute  a default  under,  or event  which,  with notice or lapse of time or
both,  would  constitute  a breach  of or  default  under,  (iii)  result in the
creation of any lien,  security interest,  adverse claim,  charge or encumbrance
upon the capital stock or assets of the Company pursuant to, (iv) give any third
party the right to accelerate any obligation under or terminate, (v) result in a
violation  of,  (vi)  result  in the  loss of any  license,  certificate,  legal
privilege  or legal  right  enjoyed or  possessed  by the  Company or any of its
subsidiaries  under,  or (vii)  require any  authorization,  consent,  approval,
exemption  or other  action  by or  notice  to any  court or  administrative  or
governmental  body  pursuant to or require the consent of any other person under
the  Certificate  of  Incorporation  or  Bylaws  of  the  Company  or any of its
subsidiaries or any law, statute, rule or regulation to which the Company or any
of its  subsidiaries  is subject or by which any of its properties are bound, or
any agreement, instrument, order, judgment or decree to which the Company or any
of its subsidiaries is subject or by which its properties are bound.

     2.7  Litigation.   There  are  no  actions,  suits,  proceedings,   orders,
investigations or claims pending or threatened  against or affecting the Company
or any of its  subsidiaries,  at law or in equity  or before or by any  federal,
state, municipal or other governmental  department,  commission,  board, bureau,
agency or  instrumentality,  other than a claim asserting a breach of employment
against a subsidiary of the Company.

                                       12
<PAGE>

     2.8 Disclosure.  Neither this Agreement nor any of the schedules, exhibits,
written  statements,  documents  or  certificates  prepared  or  supplied by the
Company with respect to the transactions  contemplated hereby contain any untrue
statement  of a material  fact or omit a  material  fact  necessary  to make the
statements  contained  herein or therein not misleading and, to the knowledge of
the Company no fact or  circumstance  exists  which would  materially  adversely
affect the existing or expected financial condition,  operating results, assets,
customer  relations,  employee relations or business prospects of the Company or
any of its subsidiaries.

                                    ARTICLE 3

                REPRESENTATIONS AND WARRANTIES OF THE ARIES FUNDS

         The Aries Funds severally represent and warrant to VIMRx that:

     3.1  Organization.  Each is duly  organized,  validly  existing and in good
standing under its respective jurisdiction of organization, with requisite power
and authority to perform the terms of this Agreement.

     3.2  Authority  and  Consent.  This  Agreement  has been  duly  authorized,
executed and  delivered by each of them and is a valid and binding  agreement of
each of them  enforceable  against  each of them in  accordance  with its terms,
except as may be limited by  applicable  bankruptcy,  insolvency or similar laws
affecting  creditors' rights generally or the availability of equitable remedies
and no consent or  approval is  required  of any Person in  connection  with the
performance  by each of them of this  Agreement or the  consummation  by each of
them of the transactions contemplated hereby.

     3.3 The  Innovir  Shares.  At the  Closing  Date,  based  solely  upon  the
representations  made to the Aries  Funds by  Innovir  in the  Common  Stock and
Warrant  Purchase  Agreement dated August 30, 1996, by and among the Aries Funds
and  Innovir,  to our  knowledge,  the  Aries  Funds  will own,  of  record  and
beneficially,  the Innovir Shares, free and clear and, upon delivery to VIMRx of
the  certificates  therefor  duly  endorsed  for  transfer to VIMRx,  VIMRx will
acquire good, valid,  indefeasible and marketable title thereto,  free and clear
of any security interest,  lien,  restriction or other  encumbrance,  other than
restrictions under applicable federal and state securities laws.

     3.4  Examination  of  Documents,  Investment  Purposes and Legending of the
VIMRx Shares.  Aries I and Aries II have conducted such examination of materials
relating  to  VIMRx  as they  have  deemed  necessary  in  connection  with  the
transactions  contemplated  hereby;  Aries I and  Aries II are each  "Accredited
Investors"  within the meaning of Rule 501 under the  Securities Act of 1933, as
amended,  and each has had the  opportunity to discuss  VIMRx's  operations with
VIMRx's  officers and employees.  Aries I and Aries II are each acquiring  their
respective  pro  rata  portion  of the  VIMRx  Shares  for its own  account  for
investment within the contemplation of the Securities Act and not with a view to
the transfer or resale thereof, and each hereby consents to the legending of the
certificates  for the VIMRx Shares to be received with a legend in substantially
the following form:

                                       13
<PAGE>

          "THE SHARES  REPRESENTED BY THIS  CERTIFICATE  HAVE NOT BEEN
          REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
          "ACT") AND MAY NOT BE SOLD,  TRANSFERRED  OR ASSIGNED IN THE
          ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT
          FOR THESE  SHARES OR AN  OPINION  OF  VIMRx'S  COUNSEL  THAT
          REGISTRATION IS NOT REQUIRED."

     3.5  Ownership  of VIMRx  Common  Stock.  Neither  Aries I nor Aries II has
acquired  any shares of VIMRx Common  Stock in the public  market or  otherwise,
including  by exercise of options or warrants to purchase  common  stock,  other
than pursuant to the Subscription and Registration  Rights Agreement dated as of
March 21, 1996 by and among VIMRx and several parties including the Aries Funds.



                                    ARTICLE 4

                     COVENANTS OF VIMRx AND THE ARIES FUNDS

        VIMRx, Aries I and Aries II hereby severally covenant and agree:

     4.1 Further  Assurances.  To take, or cause to be taken, all actions and to
do, or cause to be done,  all things  reasonably  necessary or  desirable  under
applicable laws and regulations to consummate the  transactions  contemplated by
this Agreement  expeditiously,  including  executing and delivering such further
documents,  certificates,  applications  and  agreements  as  reasonably  may be
necessary or desirable.

     4.2 Filing and Consents.  To cooperate  with respect to (i) any filing with
any governmental body, agency, official or authority required in connection with
this Agreement or the consummation of the transactions  contemplated  hereby and
(ii) any actions,  consents,  approvals or waivers  required to be obtained from
any  Person  in  connection  with  this  Agreement  or the  consummation  of the
transactions contemplated hereby.

     4.3 Access to Information and  Confidentiality.  To afford The Aries Funds,
their counsel, financial advisors, auditors and other authorized representatives
full access,  upon reasonable  prior notice and during normal business hours, to
VIMRx's offices,  properties, books and records and to its employees, agents and
independent  accountants,  and  to  furnish  The  Aries  Funds,  their  counsel,
financial advisors, auditors and other authorized representatives such financial
and operating data and other information as may reasonably be requested,  and to
cooperate with The Aries Funds in their due diligence.

                                       14
<PAGE>


                                    ARTICLE 5

                     ADDITIONAL COVENANT OF THE ARIES FUNDS

     5.1 Additional Covenant of The Aries Funds. The Aries Funds hereby covenant
and agree,  upon twenty days prior notice from VIMRx, to exercise their warrants
to purchase  2,000,000 shares of Innovir's Common Stock at $.50 per share for an
aggregate exercise price of $1,000,000, concurrent with the exercise by VIMRx of
its warrants to purchase 1,000,000 shares of Innovir's Common Stock at $1.00 per
share for an aggregate  exercise price of $1,000,000,  conditional  upon VIMRx's
receipt from Innovir's Board of Directors of a notice that additional funding is
required and to grant VIMRx an irrevocable proxy through November 31, 1999, with
respect to the 2,000,000  shares of Innovir's  Common Stock so purchased,  which
proxy shall not restrict The Aries Fund from selling such shares, in which event
the proxy shall lapse with respect to any shares sold.


                                    ARTICLE 6

                              CONDITIONS TO CLOSING

     6.1 Conditions to Obligations  of The Aries Funds.  The  obligations of The
Aries Funds hereunder are conditioned upon the following:

               (a) All warranties and representations of VIMRx contained in this
          Agreement or in any instrument  delivered  hereunder or otherwise made
          in connection with the transactions  contemplated hereby shall be true
          and  correct on and as of the  Closing  Date,  with the same force and
          effect as if made on and as of the Closing Date.

               (b) VIMRx  shall  have  performed  and  complied  with all of the
          covenants and agreements required by or pursuant to this Agreement and
          any instrument delivered hereunder to be performed or complied with on
          or prior to the Closing Date.

               (c) No suit, action, investigation or proceeding before or by any
          federal or state court or governmental  or regulatory  authority shall
          have  been  commenced,  and  no  suit,  action  or  proceeding  by any
          governmental  or  regulatory  authority  shall  have been  threatened,
          against  VIMRx,  The Aries  Funds,  or Innovir  seeking  to  restrain,
          prevent  or modify  the  transactions  contemplated  hereby or seeking
          material  damages in connection with any of such  transactions  and no
          order of any court or administrative  agency to restrain,  prohibit or
          nullify the consummation of the transactions contemplated herein shall
          be outstanding as of the Closing Date.

               (d) All  governmental  authorities  having  jurisdiction,  to the
          extent  required  by law,  shall have  consented  to or  approved  the
          consummation of the transactions contemplated by this Agreement.

                                       15
<PAGE>

               (e) As at the Closing Date,  The Aries Funds shall have exercised
          warrants to purchase  6,000,000  shares of Innovir's Common Stock upon
          payment of an aggregate exercise price of $3,000,000 therefor.

               (f) All  documents  delivered  and action taken  pursuant  hereto
          shall be  satisfactory  in form and  substance  to The Aries Funds and
          their counsel.

     6.2 Conditions to Obligations of VIMRx.  The obligations of VIMRx hereunder
are conditioned upon the following:


               (a)  All  warranties  and  representations  of  The  Aries  Funds
          contained in this Agreement shall be true and correct on and as of the
          Closing  Date with the same  force and  effect as if made on and as of
          the Closing Date.

               (b) The Aries Funds shall have performed and complied with all of
          the covenants and agreements required by or pursuant to this Agreement
          and any  instrument  delivered  hereunder  to be performed or complied
          with on or prior to the Closing Date.

               (c) No suit, action, investigation or proceeding before or by any
          federal or state court or governmental  or regulatory  authority shall
          have  been  commenced,  and  no  suit,  action  or  proceeding  by any
          governmental  or  regulatory  authority  shall  have been  threatened,
          against VIMRx, The Aries Funds or Innovir seeking to restrain, prevent
          or modify the  transactions  contemplated  hereby or seeking  material
          damages in connection  with any of such  transactions  and no order of
          any court or administrative  agency to restrain,  prohibit, or nullify
          the  consummation  of the  transactions  contemplated  herein shall be
          outstanding as of the Closing Date.

               (d) All  governmental  authorities  having  jurisdiction,  to the
          extent  required  by law,  shall have  consented  to or  approved  the
          consummation of the transactions contemplated by this Agreement.

               (e) As at the Closing Date,  The Aries Funds shall have exercised
          warrants to purchase  6,000,000  shares of Innovir's Common Stock upon
          payment of an aggregate exercise price of $3,000,000 therefor.

               (f)  Receipt of an opinion  from an  investment  banking or other
          firm   experienced   in  rendering   "fairness   opinions"   that  the
          transactions herein provided are fair from a financial  prospective to
          VIMRx.

               (g) All  documents  delivered  and action taken  pursuant  hereto
          shall be satisfactory in form and substance to VIMRx and its counsel.

                                       16
<PAGE>

                                    ARTICLE 7

                                     CLOSING

     7.1 Closing  Date.  The closing of the  transactions  contemplated  by this
Agreement  (the  "Closing")  shall be  conditional  upon and  shall  take  place
concurrently  with the  closing  of (i) the  exercise  by Aries of  warrants  to
purchase  6,000,000 shares of Innovir's Common Stock for $3,000,000 and (ii) the
acquisition by Innovir of a subsidiary of VIMRx in exchange for Common Stock and
Warrants of Innovir,  on December 4, 1996, or such other date as the parties may
fix, (the "Closing  Date") at the offices of Epstein  Becker & Green,  P.C., 250
Park Avenue, New York, New York 10177-0077.

     7.2 Deliveries by Vimrx.  At the Closing,  VIMRx shall deliver to The Aries
Funds the following:

               (a) Stock certificates for the Initial VIMRx Shares registered in
          the names of The Aries Funds.

               (b) A  registration  rights  agreement  providing for (i) VIMRx's
          preparation,  filing and processing to effectiveness of a Registration
          Statement  on Form S-3 for the public sale of the Base VIMRx Shares by
          The Aries Funds, which registration statement shall be filed within 45
          days of the Closing Date, and (ii)  cross-indemnification  rights with
          respect thereto.

               (c) An  officers'  certificate  by the  President  and the  Chief
          Financial  Officer  of VIMRx  confirming  as at the  Closing  Date the
          correctness  of the  warranties  and  representations  of VIMRx in the
          agreement and compliance by VIMRx with the covenants and agreements to
          be performed by it under the agreement.

               (d) The  opinion  of  Epstein  Becker & Green,  P.C.,  counsel to
          VIMRx, addressed to The Aries Funds, as to Sections 2.1, 2.2, 2.3, and
          7.2(b).

     7.3  Deliveries by The Aries Funds.  At the Closing,  The Aries Funds shall
deliver to VIMRx the following:

               (a) Stock certificates for the Innovir Shares,  duly endorsed for
          transfer to VIMRx or its designee.

               (b) The Registration  Rights Agreement duly executed by The Aries
          Funds.

               (c) An  irrevocable  three-year  proxy  granting VIMRx all voting
          rights with respect to the 500,000  shares of  Innovir's  Common Stock
          being  retained by The Aries funds  following the Closing  Date,  duly
          executed,  which proxy shall not restrict The Aries Funds from selling
          such shares,  in which event the proxy shall lapse with respect to any
          shares sold.

               (d) A written  waiver and release  (the  "Release")  by The Aries
          Funds of  certain  rights  under  (i) the  Common  Stock  And  Warrant
          Purchase  Agreement dated as of August 30, 1996 by and among The Aries
          Funds and Innovir and (ii) certain other agreements with Innovir which
          such  Release  shall  be in form  and  substance  satisfactory  to the
          parties.

                                       17
<PAGE>

               (e) An officers'  certificate by an authorized  representative of
          the Aries Funds, in form and substance reasonably  satisfactory to the
          parties.
               (f) The  opinion  of  counsel to The Aries  Funds,  addressed  to
          VIMRx, in form and substance reasonably satisfactory to the parties.

                                    ARTICLE 8

                                    SURVIVAL

     8.1 Survival.  All  representations  and warranties  made in this Agreement
shall survive the delivery of this Agreement and remain in full force and effect
until December 31, 1998.

                                    ARTICLE 9

                                 INDEMNIFICATION

     9.1 Indemnification

               (a)  Indemnification  by VIMRx.  VIMRx hereby agrees to indemnify
          and hold harmless The Aries Funds from and against any and all losses,
          liabilities,  damages,  obligations,  costs and  expenses,  including,
          without  limitation,  amounts paid in settlement and reasonable  costs
          and expenses of  investigating,  preparing to defend and defending any
          claim, action, suit,  proceeding,  inquiry or investigation in respect
          thereof (such losses,  liabilities,  damages,  obligations,  costs and
          expenses as hereinabove set forth, collectively "Damages") incurred by
          The Aries Funds,  resulting  from,  relating to, or arising out of the
          inaccuracy of any  representation  or warranty  herein by VIMRx or the
          breach of any covenant herein by VIMRx.

               (b)  Indemnification by The Aries Funds. Each of The Aries Funds,
          severally,  and not  jointly,  hereby  agrees  to  indemnify  and hold
          harmless VIMRx from and against any and all Damages  incurred by VIMRx
          resulting  from,  relating to, or arising out of the inaccuracy of any
          representation  or  warranty  herein by  either  of The  Aries  Funds,
          respectively, or the breach of any covenant contained herein by either
          of The Aries Funds, respectively.

               (c) Procedure.  If any action, suit, proceeding or claim shall be
          brought against the party to be indemnified by any third party,  which
          action,  suit,  proceeding or claim,  if  determined  adversely to the
          interest of the party to be  indemnified  and which would  entitle the
          party to be  indemnified  to indemnity  pursuant to this Section 10.1,
          the party to be  indemnified  shall promptly  notify the  indemnifying
          party of the same in writing and, if the indemnifying party so elects,
          the indemnifying party shall assume the defense thereof, including the
          employment of counsel  satisfactory to the party to be indemnified and


                                       18
<PAGE>

          the payment of all reasonable  costs and expenses in respect  thereof.
          The party to be  indemnified  shall  have the right to employ  counsel
          separate from any counsel  employed by the  indemnifying  party in any
          action, suit,  proceeding or claim and to control (or, if the party to
          be indemnified has elected to allow the  indemnifying  party to assume
          the defense thereof,  participate in) the defense thereof and the fees
          and expenses of such counsel  employed by the party to be  indemnified
          shall  be  at  the  expense  of  the  party  to  be  indemnified.  The
          indemnifying  party shall not be liable for any settlement of any such
          action, suit,  proceeding or claim effected without his or its written
          consent  (which shall not be  unreasonably  withheld),  but if settled
          with the written consent of the indemnifying  party, or if there shall
          be a final judgment for plaintiff in any such action, the indemnifying
          party  agrees  to  indemnify   and  hold  harmless  the  party  to  be
          indemnified from and against any loss, liability,  obligation, damage,
          cost or expense by reason of such settlement or judgment.


                                   ARTICLE 10

                            MISCELLANEOUS PROVISIONS

     10.1 Amendment and  Modification.  This Agreement may be amended,  modified
and supplemented only by a writing signed by The Aries Funds and VIMRx.

     10.2  Waiver of  Compliance.  Any  failure  of The Aries  Funds or VIMRx to
comply with any obligation,  covenant,  agreement or condition  herein contained
may be expressly  waived, in writing only, by (i) The Aries Funds in the case of
any  failure  of VIMRx or (ii)  VIMRx in the case of any  failure  of The  Aries
Funds.  Such waiver shall be effective only in the specific instance and for the
specific purpose for which made or given.

     10.3  Expenses.  VIMRx  and The  Aries  Funds  shall  each  pay  their  own
respective   expenses   incurred  in  connection  with  this  Agreement  or  any
transaction  contemplated  by this  Agreement,  except  that VIMRx shall pay the
reasonable  fees and expenses of counsel  incurred in connection  with rendering
the opinion of counsel referred to in Section 7.3(f) hereof. The foregoing shall
not be  construed  as limiting  any other  rights  which any party may have as a
result of misrepresentation of or breach by any other party.

     10.4  Notices.  All  notices,  requests,  demands and other  communications
required or permitted  hereunder shall be in writing and shall be deemed to have
been  duly  given  when  delivered  by hand,  or when  mailed  by  certified  or
registered mail (return receipt requested), postage prepaid or when delivered by
fax (evidenced by confirmation of successful transmission), as follows:

                           A.       If to The Aries Funds:

                                    Paramount Capital Asset Management, Inc.
                                    787 Seventh Avenue
                                    New York, New York 10019
                                    Fax # (212) 554-4490
                                    Attn:  President

                                       19
<PAGE>

                                    With a copy to:

                                    Roberts, Sheridan & Kotel,
                                    A Professional Corporation
                                    640 Fifth Avenue, 15th Floor
                                    New York, New York 10019
                                    Fax # (212)
                                    Attn:  Ira L. Kotel, Esq.

or to such other  person or place as The Aries  Funds  shall  designate  by
notice in the manner provided in this Section 10.4;

                           B.       If to VIMRx:

                                    VIMRX Pharmaceuticals Inc.
                                    2751 Centerville Road
                                    Wilmington, Delaware 19808
                                    Fax # (302) 998-3794
                                    Attn:  Mr. Richard L. Dunning

                                    With a copy to:

                                    Epstein Becker & Green, P.C.
                                    250 Park Avenue
                                    New York, New York  10177
                                    Fax # (212) 661-0989
                                    Attn:  Lowell Lifschultz, Esq.

or to such other  person as VIMRx shall  designate  by notice in the manner
provided in this Section 10.4.

     10.5  Assignment.  This  Agreement  shall be binding  upon and inure to the
benefit of The Aries Funds and their respective  successors and assigns,  and to
VIMRx and its successors and assigns,  but neither this Agreement nor any of the
rights,  interests  and  obligations  hereunder  shall be assigned by either The
Aries Funds or VIMRx without the prior written consent of the others.

     10.6 Freedom of Action.  (a) The Aries Funds and their affiliates shall not
have any  obligation  to the  Company  not to (i)  engage in the same or similar
activities  or lines of  business  as the  Company  or  develop  or  market  any
products,  services  or  technologies  that does or may in the  future  compete,
directly  or  indirectly,  with those of the  Company,  (ii)  invest or own any;
interest publicly or privately in, or develop a business  relationship with, any
corporation,  partnership  or other  person  or  entity  engaged  in the same or
similar activities or lines or business as or otherwise in competition with, the
Company  or  (iii)  do  business  with  any  client,   collaborator,   licensor,
consultant,  vendor  or  customer  of the  Company.  The  Aries  Funds and their
officers, directors, employees or former employees and affiliates shall not have
any  obligation  or be liable,  to the Company  solely on account of the conduct


                                       20
<PAGE>

described in the preceding sentence. In the event that either of The Aries Funds
and any officer,  director,  employee or former  employee or  affiliate  thereof
acquires knowledge of a potential transaction,  agreement,  arrangement or other
matter  which may be a  corporate  opportunity  for both The Aries  Funds or any
affiliates  and the  Company,  neither  of The Aries  Funds nor their  officers,
directors,  employees or former  employees or affiliates  shall have any duty to
communicate or offer such corporate  opportunity to the Company;  and neither of
The Aries Funds nor their officers, directors,  employees or former employees or
affiliates shall be liable to the Company for breach of any fiduciary duty, as a
stockholder  or otherwise,  solely by reason of the fact that The Aries Funds or
any of their officers,  directors,  employees or former  employees or affiliates
pursue or acquire  such  corporate  opportunity  for either of The Aries  Funds,
direct such corporate  opportunity to another person or entity or communicate or
fail to communicate such corporate opportunity or entity to the Company. As used
in this Section,  The Aries Funds shall include their affiliates  (excluding the
Company; as an affiliate of The Aries Funds).

               (b) The  provisions of this Section 10.6 shall be  enforceable to
          the fullest extent permitted by law.

     10.7 Third  Parties.  This  Agreement  is not  intended to and shall not be
construed  to give any Person  other than the  parties  hereto any  interest  or
rights (including,  without limitation, any third party beneficiary rights) with
respect to or in connection with any agreement or provision  contained herein or
contemplated hereby.

     10.8 Governing  Law. This  Agreement  shall be governed by and construed in
accordance with the laws of the State of New York,  without regard to principles
of conflicts of laws.

     10.9  Counterparts.   This  Agreement  may  be  executed  in  two  or  more
counterparts,  each of which shall be deemed an original, but all of which taken
together shall constitute one and the same instrument.

     10.8 Headings. The headings of the sections, schedules and articles of this
Agreement are inserted for the sake of convenience only and shall not constitute
a part hereof.

     10.9  Entire  Agreement.  This  Agreement,   including  the  schedules  and
exhibits,  contains  the entire  understanding  of the parties in respect of the
subject  matter  contained  herein and  therein  and there are no other terms or
conditions,  representations or warranties, written or oral, express or implied,
except as set forth herein.

                                       21
<PAGE>

     IN WITNESS  WHEREOF,  the parties  have caused  this  Agreement  to be duly
executed as of the day and year first above written.

                         THE ARIES FUND, A CAYMAN ISLAND TRUST

                         By:  its Investment Manager,
                              PARAMOUNT CAPITAL ASSET
                              MANAGEMENT, INC.




                          By:  /s/ Lindsay A. Rosenwald, M.D.                 
                                   Lindsay A. Rosenwald, M.D., President




                          THE ARIES DOMESTIC FUND, L.P.

                          By:  its General Partner,
                               PARAMOUNT CAPITAL ASSET
                               MANAGEMENT, INC.




                           By:   /s/ Lindsay A. Rosenwald, M.D.                 
                                     Lindsay A. Rosenwald, M.D., President




                                VIMRx PHARMACEUTICALS INC.




                            By:   /s/ Richard L. Dunning                        
                                      Richard L. Dunning, President


                                       22
<PAGE>


                                                              Exhibit 2.2b




                                   AMENDMENT


     AMENDMENT  dated  December 23, 1996  ("Amendment")  to the  Agreement  (the
"November Agreement") dated November 21, 1996 by and among VIMRx Pharmaceuticals
Inc.,  a Delaware  corporation  ("VIMRx" or the  "Company"),  The Aries Fund,  A
Cayman Island Trust ("Aries I") and The Aries Domestic  Fund,  L.P. , a Delaware
limited partnership ("Aries II" and, together with Aries I, "The Aries Funds").

                                 R E C I T A L S

     WHEREAS,  the parties  have entered  into the  November  Agreement  and are
desirous of effecting an amendment thereto.

     NOW, THEREFORE, VIMRx and The Aries Funds hereby agree as follows:

               1.  Section 1.1 of the November  Agreement  is hereby  amended to
          read in full as follows:

               1.1 Exchange of Shares.  Subject to the terms and  conditions  of
          this  Agreement and in reliance upon the  representations,  warranties
          and covenants herein  contained,  on the date of closing  specified in
          Section 7.1 (the  "Closing  Date"),  The Aries Funds  hereby  agree to
          assign,  transfer  and  deliver  the  Innovir  Shares  to VIMRx or its
          designee and, in exchange  therefor,  VIMRx hereby agrees to issue and
          deliver to The Aries Funds, pro rata to their ownership of the Innovir
          Shares to be delivered,  3,000,000 shares of VIMRx's Common Stock (the
          "VIMRx  Shares"),  and  $3,000,000 by wire transfer to the  account(s)
          designated by the Aries Funds."

               2. Section 1.2 of the November Agreement is hereby deleted in its
          entirety.

               3.  Subsections  (a) and (b) of Section 7.2 are hereby amended to
          read as follows:
 
               "(a) Stock  certificates  for the VIMRx Shares  registered in the
          names of The Aries Funds.

               (b) A  registration  rights  agreement  providing for (i) VIMRx's
          preparation,  filing and processing to effectiveness of a Registration
          Statement on Form S-3 for the public sale of the VIMRx  Shares,  which
          registration  statement  shall be filed  within 45 days of the Closing
          Date, and (ii) cross-indemnification rights with respect thereto."

               4.  Except  as and to the  extent  amended  hereby  the  November
          Agreement shall remain in full force and effect.

               5.  This  Amendment   shall  be  governed  by  and  construed  in
          accordance  with the laws of the State of New York,  without regard to
          principles of conflicts of laws.

                                       23
<PAGE>
               6. This  Amendment  may be executed in two or more  counterparts,
          each of which  shall be deemed  an  original,  but all of which  taken
          together shall constitute one and the same instrument.

               IN WITNESS WHEREOF,  the parties have caused this Amendment to be
          duly executed as of the day and year first above written.


                                THE ARIES FUND, A CAYMAN ISLAND TRUST

                                By:  its Investment Manager,
                                     PARAMOUNT CAPITAL ASSET   MANAGEMENT, INC.




                        By:  /s/ Lindsay A. Rosenwald, M.D.                     
                                 Lindsay A. Rosenwald, M.D., President


                                THE ARIES DOMESTIC FUND, L.P.

                                By:  its General Partner,
                                     PARAMOUNT CAPITAL ASSET
                                     MANAGEMENT, INC.




                        By:  /s/ Lindsay A. Rosenwald, M.D.                   
                                 Lindsay A. Rosenwald, M.D., President


                                VIMRx PHARMACEUTICALS INC.




                           By:  /s/ Francis M. O'Connell                        
                                    Francis M. O'Connell
                                    Chief Financial Officer



                                       24
<PAGE>


                                                                Exhibit 2.3
 
 
 
                                    AGREEMENT


                                  by and among


                           VIMRx PHARMACEUTICALS INC.


                                       and


                           INNOVIR LABORATORIES, INC.












                            Dated: November 21, 1996

                                       25
<PAGE>

                                TABLE OF CONTENTS

                                                                     Page

AGREEMENT  ............................................................1

ARTICLE 1     EXCHANGE ................................................1
         1.1      Exchange.............................................1

ARTICLE 2     REPRESENTATIONS AND WARRANTIES OF VIMRx  ................2
         2.1      Organization and Authority...........................2
         2.2      Capitalization.......................................2
         2.3      Subsidiaries.......................................  2
         2.4      Articles of Incorporation, By-Laws and
                   Corporate Records.................................  2
         2.5      Governmental Authorizations and Other Consents.....  3
         2.6      Non-Contravention..................................  3
         2.7      Financial Statements...............................  3
         2.8      Tangible Property..................................  4
         2.9      Real Property and Leases...........................  4
         2.10     Intellectual Property..............................  4
         2.11     Tax Matters........................................  4
         2.12     Compliance with Laws...............................  5
         2.13     Permits and Licenses...............................  5
         2.14     Contracts and Agreements...........................  5
         2.15     Employee Benefits..................................  5
         2.16     Accounts Payable...................................  6
         2.17     Liabilities........................................  6
         2.18     Actions and Proceedings............................  6
         2.19     Bank Accounts, Guarantees and Powers...............  6
         2.20     Absence of Changes.................................  6
         2.21     Employee Relations.................................  7
         2.22     Affiliated Transactions............................  7
         2.23     Brokers' Fees......................................  8
         2.24     Full Disclosure....................................  8
         2.25     Employee Compensation..............................  8
         2.26     Authority..........................................  8
         2.27     Title to the VHL Shares............................  8
         2.28     Examination of Documents, Investment Purposes and
                   Legending of Innovir Shares and Innovir Warrants..  8
         2.29     Insurance..........................................  9
         2.30     Environmental......................................  9

                                       26
<PAGE>

ARTICLE 3         REPRESENTATIONS AND WARRANTIES OF INNOVIR..........  9
         3.1      Organization.......................................  9
         3.2      Authority and Consent.............................. 10
         3.3      Non-Contravention.................................. 10
         3.4      Capitalization..................................... 10
         3.5      Intellectual Property.............................. 10
         3.6      Actions and Proceedings............................ 11
         3.7      Absence of Changes................................. 11
         3.8      The Innovir Shares................................. 11
         3.9      The Innovir Warrants............................... 12
         3.11     Documents Delivered................................ 12

ARTICLE 4         CONDUCT PENDING CLOSING BY VHL AND
                   THE SUBSIDIARIES ................................. 12
         4.1      Conduct of Business................................ 12
         4.2      Certain Prohibited Activities...................... 13
         4.3      Reports; Taxes; Etc................................ 13
         4.4      Access to Information.............................. 13
         4.5      Further Assurances................................. 14
         4.6      Tax Adjustments.................................... 14
         4.7      Governmental Notification and Approvals............ 14

ARTICLE 5         CONDUCT PENDING CLOSING BY INNOVIR ................ 14
         5.1      Conduct of Business................................ 14
         5.2      Certain Prohibited Activities...................... 14
         5.3      Reports; Taxes; Etc................................ 15
         5.4      Access to Information.............................. 15
         5.5      Further Assurances................................. 15
         5.6      Tax Adjustments.................................... 16
         5.7      Governmental Notification and Approvals............ 16


ARTICLE 6         COVENANTS OF VIMRx AND INNOVIR..................... 16
         6.1      Necessary Assurances............................... 16
         6.2      Filings and Consents............................... 16
         6.3      Government Filings................................. 16
         6.4      Public Announcements............................... 17
         6.5      Confidentiality.................................... 17
         6.6      Expenses........................................... 17

                                       27
<PAGE>

ARTICLE 7         ADDITIONAL COVENANTS............................... 17
         7.1      VIMRx Covenants.................................... 17
         7.2      Innovir Covenant................................... 17

ARTICLE 8         CONDITIONS TO CLOSING.............................. 18
         8.1      Conditions to Obligations of Innovir............... 18
         8.2      Conditions to Obligations of VIMRx................. 19

ARTICLE 9         CLOSING............................................ 19
         9.1      Closing Date....................................... 19
         9.2      Deliveries by VIMRx................................ 20
         9.3      Deliveries by Innovir.............................. 20

ARTICLE 10   SURVIVAL................................................ 21
         10.1     Survival........................................... 21

ARTICLE 11   INDEMNIFICATION......................................... 21
         11.1     Indemnification.................................... 21
         11.2     Access............................................. 22

ARTICLE 12   MISCELLANEOUS PROVISIONS................................ 22
         12.1     Amendment and Modification......................... 22
         12.2     Waiver of Compliance............................... 22
         12.3     Notices............................................ 22
         12.4     Assignment......................................... 23
         12.5     Third Parties...................................... 24
         12.6     Governing Law...................................... 24
         12.7     Counterparts....................................... 24
         12.8     Headings........................................... 24
         12.9     Entire Agreement................................... 24

                                       28
<PAGE>

 
                                    AGREEMENT


     AGREEMENT  (the  "Agreement")  made this 21st day of November,  1996 by and
among VIMRx  Pharmaceuticals  Inc., a Delaware  corporation with offices at 2751
Centerville   Road,   Wilmington,   Delaware   19808   ("VIMRx"),   and  Innovir
Laboratories, Inc., a Delaware corporation with offices at 510 East 73rd Street,
New York, New York 10021 ("Innovir").

                                 R E C I T A L S

     WHEREAS, Innovir is desirous of acquiring all of the issued and outstanding
shares of the capital  stock of VIMRx  Holdings,  Ltd.,  a Delaware  corporation
("VHL")  consisting of 12,000  shares of common stock,  $.01 par value (the "VHL
Shares"),  solely  in  exchange  for  8,666,6661  shares  of  Innovir's  Class D
Convertible Preferred Stock, par value $.06 per share (the "Innovir Shares") and
five-year  warrants to purchase  1,000,000  shares of Innovir's  Common Stock at
$1.00  per  share  and  1,000,000  shares  at  $2.00  per  share  (the  "Innovir
Warrants"); and


     WHEREAS, VIMRx is the owner of the VHL Shares and is desirous of exchanging
the VHL  Shares  for the  Innovir  Shares and has agreed to cause VHL to advance
$1,000,000 to Innovir concurrent with the signing of this Agreement;


           NOW, THEREFORE, Innovir and VIMRx hereby agree as follows:


                                    ARTICLE 1


                                    EXCHANGE

     1.1 Exchange.  Subject to the terms and conditions of this Agreement and in
reliance upon the representations, warranties and covenants herein contained, on
the date of closing specified in Section 9.1 (the "Closing Date"),  VIMRx hereby
agrees to assign, transfer and deliver the VHL Shares to Innovir or its designee
and,  in  exchange  therefor,  Innovir  hereby  agrees to issue and  deliver the
Innovir Shares and the Innovir Warrants to VIMRx.


- ----------
     1 The  number  of  Innovir  Shares  were  calculated  valuing  VHL at
$13,000,000 following an additional $3,000,000 cash infusion to be made prior to
closing, divided by $1.50, the per share value attributed to the Innovir Shares.

                                       29
<PAGE>

                                    ARTICLE 2


                     REPRESENTATIONS AND WARRANTIES OF VIMRx

                 VIMRx represents and warrants to Innovir that:

     2.1  Organization  and  Authority.  VHL is a  corporation  duly  organized,
validly  existing and in good standing  under the laws of the State of Delaware,
has all requisite  corporate  power and authority to own,  lease and operate its
properties and carry on its business as now conducted, and is not required to be
qualified as a foreign corporation in any other jurisdiction.

     2.2 Capitalization. The authorized capital stock of VHL consists of 120,000
shares of common stock, $.01 par value. The VHL Shares have been duly authorized
and are validly issued, fully paid and nonassessable, constitute the only shares
of VHL outstanding and there are no outstanding rights, subscriptions, warrants,
calls, preemptive rights, options or other agreements or commitments of any kind
or  character  to purchase or  otherwise  to acquire  from VHL any shares of its
capital stock or any other  security,  and no security or obligation of any kind
convertible  into the capital stock or other  security of VHL exists in favor of
any person,  corporation,  partnership,  trust,  incorporated or  unincorporated
association,  joint venture,  joint stock company,  government (or any agency or
political subdivision thereof) or other entity of any kind ("Person").

     2.3 Subsidiaries.  VPI (UK) Ltd., incorporated in England, VPI Gesellschaft
fur die Entwicklung und Synthese von Oligomeren mbH,  organized in Germany,  and
Ribonetics GmbH Gesellschaft fur molekulare Therapie,  organized in Germany, are
wholly-owned   subsidiaries  of  VHL   (collectively,   the  "Subsidiaries"  and
individually,  a "Subsidiary") and the only subsidiaries of VHL. Each Subsidiary
has been duly  organized and is validly  existing and in good standing under the
laws of its respective  jurisdiction of organization,  with full corporate power
and authority to own, lease and operate its respective properties, no Subsidiary
is required to qualify to do  business  in the United  States,  and there are no
outstanding rights,  subscriptions,  warrants, calls, preemptive rights, options
or other  agreements  or  commitments  of any kind or  character  to purchase or
otherwise to acquire from any  Subsidiary any shares of its capital stock or any
other security,  and no security or obligation of any kind  convertible into the
capital stock or other security of any Subsidiary exists in favor of any Person.

     2.4 Articles of Incorporation, By-Laws and Corporate Records. The copies of
the Certificate of  Incorporation,  By-Laws,  stock  transfer,  minute books and
corporate records of VHL and the copies of the Memorandum of Association  and/or
organizational  documents of each Subsidiary,  which have been made available to
Innovir, are true and correct copies.

                                       30
<PAGE>


     2.5 Governmental  Authorizations and Other Consents. Except as set forth on
Schedule  2.5, no consent,  order,  license,  approval or  authorization  of, or
exemption by, or  registration  or declaration or filing with, any  governmental
authority,  bureau or agency, and no consent or approval of any other Person, is
required to be  obtained or made in  connection  with the  performance  by VIMRx
and/or  VHL or any  Subsidiary  of this  Agreement  or the  consummation  of the
transactions contemplated to be performed by each of them hereunder.

     2.6 Non-Contravention. Except as set forth on Schedule 2.6, the performance
of this  Agreement  will not (i) violate any  provision  of the  Certificate  of
Incorporation  or  By-Laws  of  VIMRx  or VHL or the  equivalent  organizational
documents of any Subsidiary; (ii) violate, conflict with or result in the breach
or  termination  of, or constitute an amendment to, or otherwise give any Person
the right to terminate,  or constitute  (or with notice or lapse of time or both
would  constitute)  a default (by way of  substitution,  novation or  otherwise)
under the terms of, any contract,  mortgage, lease, bond, indenture,  agreement,
franchise or other  instrument or obligation to which VHL or any Subsidiary is a
party or by which VHL or any  Subsidiary  or any of their  respective  assets or
properties  are bound or  affected;  (iii)  result in the  creation of any lien,
mortgage,  claim,  charge,  security  interest,   encumbrance,   restriction  or
limitation  (collectively,  "Liens") upon the properties or assets of VHL or any
Subsidiary  pursuant  to the  terms  of any  contract,  mortgage,  lease,  bond,
indenture,  agreement, franchise or other instrument or obligation; (iv) violate
any  judgment,  order,  injunction,  decree or award of any  court,  arbitrator,
administrative  agency or governmental  or regulatory  body against,  or binding
upon, VHL or any Subsidiary or any of their respective  securities,  properties,
assets or business;  (v)  constitute a violation by VHL or any Subsidiary of any
statute,  law, rule or regulation of any jurisdiction as such statute, law, rule
or regulation  relates to VHL or any  Subsidiary  or to any of their  respective
securities,  properties,  assets or  business;  or (vi)  violate  any Permit (as
defined in Section 2.14).

     2.7  Financial  Statements.  The  unaudited  balance  sheet  of VHL and its
Subsidiaries as at  September 30,  1996 (the "September 30, 1996 Balance Sheet")
and the  related  unaudited  statement  of income for the nine months then ended
(together  with the September 30, 1996 Balance  Sheet,  the  "September 30, 1996
Financial  Statements"),  together  with  the  balance  sheet  of  VHL  and  its
Subsidiaries as at December 31, 1995 (the "December 31, 1995 Balance Sheet") and
the related  statements of income,  capital and cash flows for each of the years
from inception through December 31, 1995 audited by independent certified public
accountants  (the  "Audited  Financial  Statements")  to be delivered to Innovir
prior to the Closing Date will be prepared in accordance with generally accepted
accounting  principles  ("GAAP")  consistently  applied, be true and correct and
present  fairly the financial  condition and the results of operations  and cash
flows  of VHL  and  its  Subsidiaries  as at the  respective  dates  and for the
respective periods covered thereby.

                                       31
<PAGE>

     2.8 Tangible  Property.  VHL and the Subsidiaries  have good and marketable
title to all of the assets  reflected on the September  30, 1996 Balance  Sheet,
free and clear of all Liens,  except for those assets leased under leases listed
on Schedule 2.8.


Real Property and Leases.  (a) VHL and the Subsidiaries own no real property.

               (b)  Schedule  2.9(b) sets forth a true and  correct  list of all
          leases,   subleases  or  other  agreements  under  which  VHL  or  any
          Subsidiary  is  lessee  or  lessor  of any  real  property  or has any
          interest in real property and, except as set forth in Schedule 2.9(b),
          there are no rights or options  held by VHL or any  Subsidiary  or any
          contractual obligations to purchase or otherwise acquire (including by
          way of lease or sublease) any interest in or use of any real property,
          nor any rights or options  granted  by VHL or any  Subsidiary,  or any
          contractual  obligations to sell or otherwise dispose of (including by
          way of lease or sublease) any interest in or use of any real property.
          All such leases,  subleases and other agreements are in full force and
          effect and  constitute  legal,  valid and binding  obligations  of the
          respective  parties  thereto,  with no existing or claimed  default or
          event of default,  or event which with notice or lapse of time or both
          would constitute a default or event of default, by VHL, any Subsidiary
          or, to the knowledge of VIMRx, by any other party thereto, which would
          materially and adversely  affect VHL or any Subsidiary,  and grant the
          leasehold  estates or other  interests  they purport to grant with the
          right  to  quiet  possession.  VHL  and  the  Subsidiaries  are not in
          violation of any building,  zoning, health,  safety,  environmental or
          other law, rule or  regulation  and no notice from any Person has been
          served upon VHL or any Subsidiary claiming any such violation.

     2.10  Intellectual  Property.  Schedule 2.10 sets forth (i) all trademarks,
trade  names,  trade  secrets,  patents,  inventions,   processes,   copyrights,
copyright  rights  or  other  intellectual   property  rights  (or  applications
therefor) used by VHL and the  Subsidiaries in connection with their  respective
business,  (ii) whether such property is owned,  licensed or leased, and (iii) a
summary of the terms of the  license or lease.  VHL has not made any  commercial
sale of synthetic  catalytic  oligonucleotides  in the United States through the
date hereof.

     2.11 Tax Matters. VHL and the Subsidiaries have timely filed all applicable
tax returns,  estimates  and reports  (collectively,  "Returns")  required to be
filed by them  through the date hereof,  copies of which have been  delivered to
Innovir, which Returns accurately reflect the taxes, if any, due for the periods
indicated,  and have  paid in full all  income,  gross  receipts,  value  added,
excise, property, franchise, sales, use, employment,  payroll and other taxes of
any kind whatsoever (collectively, "Taxes") shown to be due by such Returns, and
have  established  adequate  reserves with respect to any  liabilities for Taxes
accrued  through  December 31, 1995 which are reflected on the December 31, 1995
Balance Sheet and VIMRx has no knowledge of any unassessed  deficiency for Taxes
proposed or threatened against VHL and the Subsidiaries, and no taxing authority
has raised any issue which, if adversely determined, would result in a liability
for any Tax which has not been reserved against on the December 31, 1995 Balance
Sheet. No extensions with respect to the dates on which any Return was or is due
to be filed by VHL or any  Subsidiary  nor any waivers or  agreements by VHL and


                                       32
<PAGE>

the  Subsidiaries for the extension of time for the assessment or payment of any
Taxes are in force.  Neither VHL nor any  Subsidiary  has been, nor currently is
being, audited by any tax authority.

     2.12 Compliance with Laws. VHL and the Subsidiaries are not in violation of
any applicable law, rule or regulation,  the violation of which could materially
and adversely affect their assets, properties, liabilities, business, results of
operations, condition (financial or otherwise) or prospects, nor does VIMRx know
of the enactment,  promulgation  or adoption of any such law, rule or regulation
which is not yet effective.

     2.13 Permits and Licenses.  Except as set forth on Schedule  2.13,  VHL and
the  Subsidiaries  have duly  obtained  and hold in full  force and  effect  all
consents,  authorizations,  permits,  licenses,  orders or approvals of, and has
made all declarations and filings with, all federal, state or local governmental
or  regulatory  bodies that are  material or  necessary  in the conduct of their
respective  business  (collectively,  the "Permits");  all the Permits were duly
obtained  and are in full  force  and  effect;  no  violations  are or have been
recorded  in  respect  of any  such  Permit  and no  proceeding  is  pending  or
threatened to revoke, deny or limit any such Permit.

     2.14 Contracts and  Agreements.  Schedule 2.14 lists and briefly  describes
all written or oral contracts,  agreements, leases, mortgages and commitments to
which  VHL or any  Subsidiary  is a  party/or  by which any of them may be bound
involving in excess of $25,000, including, without limitation, all collaboration
agreements,  management agreements, joint venture agreements, leases, guarantees
and  indemnifications,  employment and consulting  agreements and instruments of
indebtedness (individually, a "Contract" and, collectively,  "Contracts"),  true
and correct copies of which have been made  available to Innovir.  All Contracts
constitute legal, valid and binding  obligations of VHL or the Subsidiaries and,
to the best knowledge of VIMRx,  of the other parties  thereto,  and are in full
force and effect on the date hereof,  and VHL or the  Subsidiaries  have paid in
full all amounts due thereunder which are due and payable and are not in default
under any such Contract nor, to the best knowledge of VIMRx,  is any other party
to any such Contract in default  thereunder,  nor does any condition  exist that
with  notice or lapse of time or both  would  constitute  a default  or event of
default  thereunder  by VHL or the  Subsidiaries  or, to the best  knowledge  of
VIMRx,  by any other  Person.  Except as set forth in Schedule  2.5, no Contract
requires  the  consent  or  approval  of a third  party in  connection  with the
performance  by VHL or any  Subsidiary  of this  Agreement  or the  transactions
contemplated to be performed by it hereunder.

     2.15 Employee Benefits.  Except as set forth on Schedule 2.15, there are no
pension, retirement, savings, disability, medical, dental or other health plans,
life insurance  (including any individual life insurance  policy as to which VHL
or any Subsidiary makes premium payments whether or not VHL or the Subsidiary is
the owner,  beneficiary,  or both, of such policy) or other death benefit plans,
profit sharing,  deferred  compensation,  stock option, bonus or other incentive
plans, vacation benefit plans,  severance plans, or other employee benefit plans
or arrangements (whether written or arising from custom).

                                       33
<PAGE>

     2.16 Accounts  Payable.  Except as set forth on Schedule  2.16, no accounts
payable of VHL or any  Subsidiary  have arisen  subsequent to September 30, 1996
that exceed $10,000 for any one payee or $25,000 in the aggregate.

     2.17 Liabilities.  There are no material  liabilities or obligations of VHL
and  the  Subsidiaries  either  accrued,   absolute,   contingent  or  otherwise
("Liabilities"),  whether or not of a kind required by GAAP to be set forth on a
financial statement,  except (i) those accrued,  reflected or otherwise provided
for on the  September 30, 1996 Balance  Sheet  furnished to Innovir,  (ii) those
incurred in the ordinary course of business since September 30, 1996, consistent
with past practices,  and which in the aggregate do not exceed $25,000 and (iii)
those listed on Schedule 2.17.

     2.18 Actions and  Proceedings.  Except as set forth on Schedule 2.18, there
are no claims,  actions,  suits,  arbitrations,  proceedings,  investigations or
inquiries,  whether  at law or in equity  and  whether  or not before any court,
private body or group,  governmental  department,  commission,  board, agency or
instrumentality  (collectively,  "Actions"),  pending,  or to the  knowledge  of
VIMRx, threatened against,  involving or affecting VHL, any Subsidiary or any of
their respective assets, whether or not fully or partially covered by insurance,
or which would give rise to any right of  indemnification by any Person from VHL
or any  Subsidiary,  and there are no outstanding  orders,  writs,  injunctions,
awards,  sentences or decrees of any court, private body or group,  governmental
department,  commission,  board, agency or instrumentality against, involving or
affecting VHL or any Subsidiary or their respective assets or business.

     2.19 Bank Accounts,  Guarantees and Powers.  Schedule 2.19 sets forth (i) a
list of all accounts,  borrowing resolutions and deposit boxes maintained by VHL
and each Subsidiary at any bank or other financial  institution and the names of
the  persons  authorized  to effect  transactions  in such  accounts,  to borrow
pursuant to such resolutions and with access to such boxes;  (ii) all agreements
or commitments of VHL and each Subsidiary  guaranteeing  the payment of money or
the performance of other contracts by any third persons;  and (iii) the names of
all  Persons  holding  general  or  special  powers  of  attorney  from VHL or a
Subsidiary, together with a summary of the terms thereof.

     2.20  Absence  of  Changes.  Except as set forth in  Schedule  2.20,  since
September 30, 1996, VHL and the  Subsidiaries  have carried on their  respective
business in the ordinary course, and there has not been:

          (i) any material adverse change in their respective business condition
          (financial or otherwise), results of operations or liabilities;

          (ii) any pending or threatened amendment, modification, or termination
          of any  agreement  or Permit  which is  material  to their  respective
          business;

                                       34
<PAGE>

          (iii) any disposition or acquisition of any of their respective assets
          or properties,  other than in the ordinary course, which exceed $2,500
          in the aggregate;

          (iv) any damage,  destruction  or other  casualty loss (whether or not
          covered by insurance)  adversely affecting or that could reasonably be
          expected to adversely affect their respective business or assets;

          (v)  any  increase  in the  compensation  of any of  their  respective
          employees or consultants; or

          (vi) except in the ordinary  course,  the incurrence of any obligation
          or  liability   (whether  matured,   unmatured,   absolute,   accrued,
          contingent or otherwise) which exceed $2,500 in the aggregate.

     2.21  Employee  Relations.  VHL and the  Subsidiaries  have not at any time
during  the last  five  years  had,  or to the  knowledge  of VIMRx is there now
threatened,  a strike,  picket,  work stoppage,  work  slowdown,  or other labor
trouble or dispute,  and VIMRx has no knowledge of the proposed  resignation  of
any employee of VHL or any Subsidiary whose annual salary exceeds $25,000.

     2.22 Affiliated Transactions.  For purposes of this Section, an "Affiliate"
means VIMRx or any employee, officer or director of VHL or any Subsidiary or any
spouse or family  member  (including  in-laws) of, or any  corporation  or other
entity "controlled by" (as such term is defined in Rule 405 of the General Rules
and Regulations under the Securities Act of 1993, as amended),  any such persons
or in which any such person has an equity or ownership  interest  exceeding five
percent.

               (a) Except as specifically set forth  (including  dollar amounts)
          on Schedule 2.22, as of the date hereof,  no Affiliate is indebted to,
          or is a creditor of, VHL or any Subsidiary.

               (b)  During  the past  three  (3)  years,  except as set forth on
          Schedule  2.22  neither  VHL  nor  any  Subsidiary  has,  directly  or
          indirectly,  purchased, leased from or otherwise acquired any property
          or  obtained  any  services  from,  or sold,  leased  to or  otherwise
          disposed of any  property or  furnished  any services to, or otherwise
          dealt with,  any Affiliate nor is VHL or any Subsidiary a party to any
          contract, agreement, license, commitment or other arrangement, written
          or oral, express or implied,  with an Affiliate except as disclosed on
          such schedule.

                                       35
<PAGE>

     2.23  Brokers'  Fees.  There is no  broker,  finder  or other  intermediary
retained  by VIMRx,  VHL or any  Subsidiary  who might be  entitled  to a fee or
commission in connection with the transactions contemplated hereby.

     2.24 Full Disclosure.  All documents,  schedules,  financial statements and
other  materials  delivered or made available by or on behalf of VIMRx or VHL or
any Subsidiary to Innovir in connection with this Agreement and the transactions
contemplated  hereby  are  true  and  correct  in  all  material  respects.  The
information furnished to Innovir by or on behalf of VIMRx, VHL or any Subsidiary
in connection with this Agreement and the transactions  contemplated hereby does
not, in light of the circumstances  under which the statements  contained in the
information so furnished were made,  contain any untrue  statement of a material
fact or omit to  state  any  material  fact  necessary  to make  the  statements
contained therein not false or misleading.

     2.25  Employee  Compensation.  Schedule 2.25 lists all employees of VHL and
each Subsidiary,  setting forth their respective  annual salaries,  whether they
are  employed  under  contract  or at  will,  and  the  expiration  date of each
contract.

     2.26  Authority.  This  Agreement  has been duly  executed and delivered by
VIMRx and is a valid and binding agreement of VIMRx enforceable against VIMRx in
accordance  with its terms,  except as may be limited by applicable  bankruptcy,
insolvency  or  similar  laws  affecting  creditors'  rights  generally  or  the
availability of equitable remedies.

     2.27 Title to the VHL Shares.  VIMRx owns the VHL Shares, free and clear of
all Liens  and,  upon  delivery  to Innovir of the  certificates  therefor  duly
endorsed for transfer to Innovir, Innovir will acquire good, valid, indefeasible
and marketable title thereto, free and clear of any and all Liens.

     2.28 Examination of Documents, Investment Purposes and Legending of Innovir
Shares and  Examination  of  Documents,  Investment  Purposes  and  Legending of
Innovir  Shares and Innovir  Warrants.  VIMRx has examined the Annual  Report on
Form 10-K of Innovir  for the fiscal  year ended  September  30, 1995 (the "1995
Form 10-K"),  Innovir's  Quarterly  Reports on Form 10-Q for the quarters  ended
December 31, 1995,  March 31, 1996 and June 30, 1996,  Innovir's Proxy Statement
for its 1994 Annual Meeting of Stockholders  and Innovir's 1994 Annual Report to
Stockholders,  has had the  opportunity  to discuss  Innovir's  operations  with
Innovir's  officers and  employees,  and is acquiring the Innovir Shares and the
Innovir Warrants for its own account for investment  within the contemplation of
the  Securities  Act of 1933, as amended (the  "Securities  Act") and not with a
view to the transfer or resale  thereof,  and  consents to the  legending of the
certificates   for  the  Innovir   Shares  to  be  received  with  a  legend  in
substantially the following form:

               "THE SHARES  REPRESENTED BY THIS  CERTIFICATE  HAVE NOT
               BEEN  REGISTERED  UNDER THE  SECURITIES ACT OF 1933, AS
               AMENDED (THE "ACT") AND MAY NOT BE SOLD, TRANSFERRED OR
               ASSIGNED  IN THE ABSENCE OF AN  EFFECTIVE  REGISTRATION
               STATEMENT  UNDER THE ACT FOR THESE SHARES OR AN OPINION
               OF   INNOVIR'S   COUNSEL  THAT   REGISTRATION   IS  NOT
               REQUIRED",

                                       36
<PAGE>

and to the affixation of a similar legend on the Innovir Warrants.

     2.29  Insurance.  Schedule 2.29  contains a list of all insurance  policies
covering the respective assets, businesses,  operations, employees, officers and
directors  of VHL and each  Subsidiary,  and the dates  through  which each such
policy is  effective.  Each such policy is in full force and effect and evidence
of the  effectiveness of each such policy has been delivered to Innovir.  Except
as set  forth in  Schedule  2.29,  there  is no  claim by VHL or any  Subsidiary
pending  under any of such  policies as to which  coverage has been  questioned,
denied or disputed by the  underwriters of such policies.  All premiums  payable
under such policies have been paid, and VHL and each  Subsidiary is otherwise in
full  compliance  with the terms and conditions of such policies.  Such policies
are of the types and in the amounts  customarily  carried by Persons  conducting
businesses similar to those of VHL and the Subsidiaries.  Neither VIMRx, VHL nor
any Subsidiary  has any knowledge of any  threatened  termination of any of such
policies.

     2.30 Environmental.  VHL and each Subsidiary currently operates, and at all
times  in the  past has  operated,  in  compliance  with  all  applicable  laws,
statutes, codes, ordinances,  rules, regulations, or other requirements relating
to the protection of human health and safety,  the environment,  or hazardous or
toxic substances or waste,  pollutants or contaminants  ("Environmental  Laws").
None of VIMRx,  VHL or any  Subsidiary  has  received  any  notification  of any
present or past failure on the part of VHL or any  Subsidiary to comply with any
applicable  Environmental Laws. No Lien has attached to, and no basis exists for
the  attachment  of any Lien to, any revenues of VHL or any  Subsidiary or their
respective  assets pursuant to any  Environmental  Laws.  There has not been any
Phase I, Phase II or other environmental report conducted by or on behalf of VHL
or any Subsidiary with respect to their respective properties or assets.

                                    ARTICLE 3

                    REPRESENTATIONS AND WARRANTIES OF INNOVIR

                 Innovir represents and warrants to VIMRx that:

     3.1 Organization. Innovir is a corporation duly organized, validly existing
and in good standing under the laws of the State of Delaware,  has all requisite
corporate  power and authority to own,  lease and operate its  properties and to
carry on its business as now being conducted, and is duly qualified and licensed
as a foreign  corporation  to transact  business and is in good standing in each
jurisdiction in which it is required to be so qualified or authorized.

                                       37
<PAGE>

     3.2  Authority  and  Consent.  This  Agreement  has been  duly  authorized,
executed  and  delivered  by Innovir  and is a valid and  binding  agreement  of
Innovir  enforceable against Innovir in accordance with its terms, except as may
be limited by  applicable  bankruptcy,  insolvency  or  similar  laws  affecting
creditors'  rights  generally or the  availability of equitable  remedies and no
consent or approval is required of any Person in connection with the performance
by Innovir of this Agreement or the  consummation by Innovir of the transactions
contemplated hereby.

     3.3 Non-Contravention. Except as set forth on Schedule 3.3, the performance
of  this  Agreement  by  Innovir  will  not (i)  violate  any  provision  of its
Certificate of Incorporation or By-Laws;  (ii) violate,  conflict with or result
in the breach or  termination  of, or  constitute  an amendment to, or otherwise
give any Person the right to terminate,  or constitute  (or with notice or lapse
of time or both would constitute) a default (by way of substitution, novation or
otherwise) under the terms of, any contract,  mortgage,  lease, bond, indenture,
agreement,  franchise or other  instrument  or  obligation to which Innovir is a
party or by which it or any of its assets or  properties  are bound or affected;
(iii)  result in the  creation  of any Liens  upon the  properties  or assets of
Innovir pursuant to the terms of any contract, mortgage, lease, bond, indenture,
agreement,  franchise  or other  instrument  or  obligation;  (iv)  violate  any
judgment,  order,  injunction,   decree  or  award  of  any  court,  arbitrator,
administrative  agency or governmental  or regulatory  body against,  or binding
upon,  Innovir or any of its  securities,  properties,  assets or business;  (v)
constitute a violation by Innovir of any statute, law, rule or regulation of any
jurisdiction as such statute,  law, rule or regulation  relates to Innovir or to
any of its securities,  properties,  assets or business; (vi) violate any Permit
(as defined in Section 2.13);  or (vi) result in an adjustment to the conversion
or exercise price of any of Innovir's outstanding securities.

     3.4  Capitalization.  Innovir's  authorized  capital stock  consists of (i)
15,000,000  shares  of  preferred  stock,  of which  297,000  shares  of Class B
Convertible  Preferred Stock and 20,000 shares of Class C Convertible  Preferred
Stock are issued and outstanding, and (ii) 35,000,000 shares of Common Stock, of
which  11,780,646  shares  are  issued and  outstanding,  14,616,500  shares are
reserved for issuance upon exercise of warrants  (8,000,000 shares at a price of
$.50 per share and  6,616,500  shares at prices  ranging from $0.05 per share to
$10.67 per share and averaging $5.07 per share),  1,646,625  shares are reserved
for issuance  upon  exercise of  outstanding  employee  stock  options at prices
ranging from $0.97 per share to $12.00 per share and averaging  $4.21 per share,
629,289  shares  are  reserved  for  issuance  upon  conversion  of  convertible
preferred  stock and 519,736  shares are reserved for future option grants under
Innovir's stock option plan.

     3.5  Intellectual  Property.  Schedule  3.5 sets forth (i) all  trademarks,
trade  names,  trade  secrets,  patents,  inventions,   processes,   copyrights,
copyright  rights  or  other  intellectual   property  rights  (or  applications
therefor)  used by Innovir in connection  with its  business,  (ii) whether such
property is owned,  licensed or leased,  and (iii) a summary of the terms of the
license or lease.

                                       38
<PAGE>

     3.6 Actions and Proceedings. Except as set forth on Schedule 3.6, there are
no Actions pending, or to the knowledge of Innovir threatened against, involving
or  affecting  Innovir or any of its assets,  whether or not fully or  partially
covered by insurance or which would give rise to any right of indemnification by
any  Person  from  Innovir,   and  there  are  no  outstanding  orders,   writs,
injunctions,  awards,  sentences or decrees of any court, private body or group,
governmental department,  commission,  board, agency or instrumentality against,
involving or affecting Innovir, its assets or business.

     3.7  Absence  of  Changes.  Except  as set  forth in  Schedule  3.7,  since
September 30, 1996,  Innovir has carried on its business in the ordinary course,
and there has not been:

               (i)  any  material  adverse  change  in  its  business  condition
               (financial or otherwise), results of operations or liabilities;

               (ii)  any  pending  or  threatened  amendment,  modification,  or
               termination  of any  agreement or Permit which is material to its
               business;

               (iii) any  disposition  or  acquisition  of any of its  assets or
               properties,  other  than in the  ordinary  course,  which  exceed
               $2,500 in the aggregate;

               (iv) any damage,  destruction  or other casualty loss (whether or
               not  covered  by  insurance)  adversely  affecting  or that could
               reasonably  be  expected  to  adversely  affect its  business  or
               assets;

               (v) any modification to any existing, or the adoption or entrance
               into any new,  employee  benefit  plan,  employment  agreement or
               consulting agreement,  or the increase in the compensation of any
               of its employees or consultants; or

               (vi)  except  in  the  ordinary  course,  the  incurrence  of any
               obligation or liability  (whether matured,  unmatured,  absolute,
               accrued,  contingent  or  otherwise)  which exceed  $2,500 in the
               aggregate.

     3.8 The Innovir  Shares.  The Innovir Shares to be delivered  hereby,  when
issued and delivered in  accordance  with the terms of this  Agreement,  will be
validly  issued,  fully paid and  non-assessable  and will  conform to the terms
thereof set forth on  Schedule  3.8 and,  following  the  increase of  Innovir's
authorized  Common Stock to 70,000,000  shares,  the shares of Innovir's  Common
Stock issuable upon  conversion  thereof will be duly reserved for issuance and,
when  issued  upon such  conversion,  will be  validly  issued,  fully  paid and
non-assessable.

                                       39
<PAGE>

     3.9 The Innovir Warrants. The Innovir Warrants to be delivered hereby, when
issued and delivered in  accordance  with the terms of this  Agreement,  will be
duly  authorized  and  executed,  will conform to the terms thereof set forth on
Schedule  3.9 and will  constitute  valid and  legally  binding  obligations  of
Innovir,  enforceable in accordance with their terms and, following the increase
of  Innovir's  authorized  Common  Stock to  70,000,000  shares,  the  shares of
Innovir's  Common Stock issuable upon exercise thereof will be duly reserved for
issuance and, when issued upon such exercise, will be validly issued, fully paid
and non-assessable.

     3.10 Investment  Purposes.  Innovir is acquiring the VHL Shares for its own
account for investment  within the  contemplation  of the Securities Act and not
with a view to the transfer or resale thereof.

     3.11  Documents  Delivered.  Innovir has delivered to VIMRx,  Innovir's (i)
Annual  Report on Form 10-K for its fiscal  year ended  September  30, 1995 (ii)
Quarterly  Reports on Form 10-Q for the quarters ended December 31, 1995,  March
31, 1996 and June 30, 1996 (iii) Proxy  Statement for its 1994 Annual Meeting of
Stockholders  and (iv) its  Prospectus  dated  October  8, 1996 and the  related
Registration Statement on Form S-3 (collectively,  the "SEC Documents"). The SEC
Documents,  including the financial statements included therein,  complied as to
form with the  requirements  of the Securities  Exchange Act of 1934, as amended
and the rules and regulations  thereunder (and, with respect to the Registration
Statement  on Form S-3,  the  Securities  Act),  were true and  complete  in all
material  respects as at their respective  dates, and did not contain any untrue
statement of a material  fact nor omit to state any material fact required to be
stated therein or necessary to make the statements  contained therein,  in light
of the circumstances  under which they were made, not misleading.  The unaudited
financial statements of Innovir as at September 30, 1996 and for the three years
then  ended  delivered  to VIMRx  have been  prepared  in  accordance  with GAAP
consistently  applied,  are true and correct and  present  fairly the  financial
condition  and the  results  of  operations  and cash flows of Innovir as at the
respective  dates and for the  respective  periods  covered  thereby,  except as
disclosed in Schedule 3.11.

                                    ARTICLE 4

               CONDUCT PENDING CLOSING BY VHL AND THE SUBSIDIARIES

     From the date  hereof  and  until the  Closing  Date,  except as  otherwise
provided  by this  Agreement  or as agreed by Innovir in writing,  VIMRx  hereby
covenants and agrees that it shall cause VHL and each  Subsidiary to comply with
each of the following covenants:

     4.1 Conduct of Business.  To conduct its  business in the  ordinary  course
consistent with past practice, maintain adequate insurance,  preserve intact its
business organization and employees,  maintain  satisfactory  relationships with
its  independent  agents,  and others  having  business  relationships  with it,


                                       40
<PAGE>

maintain  its books and  records in its usual  manner and not make any change in
its  financial  reporting,  or  accounting  practices  or  policies,  or in  its
reserving practices or policies.

     4.2 Certain Prohibited  Activities.  Not to (i) issue, sell or deliver,  or
agree to issue,  sell or deliver,  any shares of its capital  stock or any other
security (whether  authorized and unissued or held as treasury shares), or grant
or issue, or agree to grant or issue, any subscription, option, warrant or other
right calling for the issue, sale or delivery  thereof;  (ii) declare or pay any
dividend or  distribution  on any shares of its capital stock;  (iii)  purchase,
redeem or  otherwise  acquire  any shares of its  capital  stock;  (iv) make any
change in any pension or employee benefit plan or arrangement, or any collective
bargaining agreement,  or enter into, amend, modify or terminate any arrangement
or  agreement  with any officer,  director,  employee,  independent  contractor,
representative;  (v) create,  incur,  assume or guarantee any  indebtedness  for
borrowed money; (vi) make any capital expenditure, or purchase, lease or license
any real or personal  property which exceed $2,500 in the aggregate;  (vii) sell
or otherwise  dispose of or pledge any of its assets (tangible or intangible) or
cancel any debts or claims (including, without limitation,  accounts receivable)
owing to it, except in the ordinary  course of business which does not otherwise
violate this  Agreement;  (viii) merge or  consolidate  with any other Person or
acquire  control  of all or any  substantial  portion of the assets of any other
Person  or take  any  steps  incident  to,  or in  furtherance  of,  merging  or
consolidating with or acquiring control of all or any substantial portion of the
assets of any other  Person,  whether by entering  into an  agreement  providing
therefor  or  otherwise;  (ix)  make or cause to be made any  alteration  in the
manner of keeping its books,  accounts or records or in the accounting practices
and principles therein and theretofore reflected, except as required by law; (x)
effect  or agree  to any  change  in its  articles  or  similar  instruments  of
organization  (except  that VHL is  discontinuing  in the Islands of Bermuda and
domesticating  in the State of  Delaware)  or  By-Laws;  (xi) settle or agree to
settle any claim, action, suit or proceeding involving the payment or receipt of
more than $5,000,  individually,  or $10,000, in the aggregate; (xii) enter into
any other transaction or agreement which is not in the ordinary and usual course
of business; or (xiii) agree or commit to do any of the foregoing.

     4.3 Reports;  Taxes;  Etc. To duly and timely file, or cause to be duly and
timely filed, all filings, declarations, reports or returns required to be filed
with  governmental  authorities  and to promptly pay all taxes,  assessments and
governmental charges lawfully levied or assessed.

     4.4  Access to  Information.  To afford  Innovir,  its  counsel,  financial
advisors,  auditors  and other  authorized  representatives  full  access,  upon
reasonable  prior  notice and during  normal  business  hours,  to its  offices,
properties,  books and  records  and to its  employees,  agents and  independent
accountants,  and to  furnish  to  Innovir,  its  counsel,  financial  advisors,
auditors and other authorized  representatives such financial and operating data
and other  information  as may  reasonably  be  requested,  and to instruct  its
employees, counsel and financial advisors to cooperate with Innovir in Innovir's
due diligence.

                                       41
<PAGE>

     4.5 Further  Assurances.  To do or cause to be done such  further  acts and
things  and  deliver  or  cause  to be  delivered  to  Innovir  such  additional
assignments,  agreements,  powers  and  instruments  as Innovir  may  reasonably
require or deem  reasonably  advisable to carry into effect the purposes of this
Agreement  or the other  agreements  to be entered into in  connection  with the
transactions  contemplated  hereby or to better  assure and  confirm the rights,
powers and remedies of Innovir hereunder and thereunder.

     4.6 Tax Adjustments. To promptly notify Innovir of all proposed adjustments
contained in examination  reports  received from any tax authority to any Return
relating to  adjustment  for tax years prior to and  including  the Closing Date
which could  materially  adversely  affect VHL, any Subsidiary or Innovir and to
provide Innovir and its representatives such information and records as they may
reasonably  request with  respect to such  adjustments.  Innovir  shall have the
right to participate in and pay its own expenses  relating to the contest of all
such proposed  adjustments  which might adversely affect Innovir by the creation
of adverse precedent or otherwise.

     4.7 Governmental  Notification and Approvals. To prepare promptly, file and
diligently pursue with the appropriate  governmental  agencies all documentation
and information  required by law or requested by each such agency to be filed to
permit the consummation of the transactions contemplated hereby.

                                    ARTICLE 5

                       CONDUCT PENDING CLOSING BY INNOVIR

     From the date  hereof  and  until the  Closing  Date,  except as  otherwise
provided  by this  Agreement  or as agreed by VIMRx in writing,  Innovir  hereby
covenants and agrees, as follows:

     5.1 Conduct of Business.  To conduct its  business in the  ordinary  course
consistent with past practice, maintain adequate insurance,  preserve intact its
business organization and employees,  maintain  satisfactory  relationships with
its  independent  agents,  and others  having  business  relationships  with it,
maintain  its books and  records in its usual  manner and not make any change in
its  financial  reporting,  or  accounting  practices  or  policies,  or in  its
reserving practices or policies.

     5.2 Certain Prohibited  Activities.  Not to (i) issue, sell or deliver,  or
agree to issue,  sell or deliver,  any shares of its capital  stock or any other
security  (whether  authorized and unissued or held as treasury  shares),  other
than upon the exercise of outstanding  options or warrants or upon conversion of
outstanding  preferred stock, or grant or issue, or agree to grant or issue, any
subscription,  option,  warrant or other right  calling  for the issue,  sale or
delivery  thereof,  except that Innovir may grant (x) new employee stock options
to purchase Innovir's Common Stock at $1.30 per share in replacement of existing
employee  stock options and to employees who have not  theretofore  been granted


                                       42
<PAGE>

options, all such grants of stock options being substantially in accordance with
Schedule  5.2, with new vesting  provisions  approved by VIMRx and provided that
such  vesting  provisions  do  not  accelerate  upon  the  consummation  of  the
transactions  herein  provided  and (y)  warrants to purchase  20,000  shares of
Innovir's  Common  Stock  at $1.50  per  share to New  York  State  Science  and
Technology  Foundation,  (ii) declare or pay any dividend or distribution on any
shares of its capital stock;  (iii)  purchase,  redeem or otherwise  acquire any
shares of its  capital  stock;  (iv) make any change in any  pension or employee
benefit plan or arrangement,  or any collective bargaining  agreement,  or enter
into, amend,  modify or terminate any arrangement or agreement with any officer,
director, employee, independent contractor,  representative;  (v) create, incur,
assume or guarantee any indebtedness  for borrowed money;  (vi) make any capital
expenditure,  or purchase,  lease or license any real or personal property which
exceed $2,500 in the aggregate; (vii) sell or otherwise dispose of or pledge any
of its assets (tangible or intangible) or cancel any debts or claims (including,
without  limitation,  accounts  receivable)  owing to it, except in the ordinary
course of business which does not otherwise violate this Agreement; (viii) merge
or  consolidate  with  any  other  Person  or  acquire  control  of  all  or any
substantial portion of the assets of any other Person or take any steps incident
to, or in furtherance of, merging or consolidating  with or acquiring control of
all or any  substantial  portion of the assets of any other  Person,  whether by
entering into an agreement  providing therefor or otherwise;  (ix) make or cause
to be made any  alteration  in the manner of  keeping  its  books,  accounts  or
records or in the accounting  practices and principles  therein and  theretofore
reflected,  except as required by law;  (x) effect or agree to any change in its
Certificate  of  Incorporation  or  By-laws;  (xi) settle or agree to settle any
claim,  action, suit or proceeding involving the payment or receipt of more than
$5,000,  individually,  or $10,000, in the aggregate; (xii) enter into any other
transaction  or  agreement  which is not in the  ordinary  and  usual  course of
business; or (xiii) agree or commit to do any of the foregoing.

     5.3 Reports;  Taxes;  Etc. To duly and timely file, or cause to be duly and
timely filed, all filings, declarations, reports or returns required to be filed
with  governmental  authorities  and to promptly pay all taxes,  assessments and
governmental charges lawfully levied or assessed.

     5.4  Access  to  Information.  To  afford  VIMRx,  its  counsel,  financial
advisors,  auditors  and other  authorized  representatives  full  access,  upon
reasonable  prior  notice and during  normal  business  hours,  to its  offices,
properties,  books and  records  and to its  employees,  agents and  independent
accountants, and to furnish VIMRx, its counsel, financial advisors, auditors and
other  authorized  representatives  such  financial and operating data and other
information  as may  reasonably  be  requested,  and to instruct its  employees,
counsel and financial advisors to cooperate with VIMRx in VIMRx's due diligence.

     5.5 Further  Assurances.  To do or cause to be done such  further  acts and
things  and  deliver  or  cause  to  be  delivered  to  VIMRx  such   additional
assignments,  agreements, powers and instruments as VIMRx may reasonably require
or deem reasonably advisable to carry into effect the purposes of this Agreement


                                       43
<PAGE>

or the other  agreements to be entered into in connection with the  transactions
contemplated  hereby or to better  assure and  confirm  the  rights,  powers and
remedies of VIMRx hereunder and thereunder.

     5.6 Tax Adjustments.  To promptly notify VIMRx of all proposed  adjustments
contained in examination  reports  received from any tax authority to any Return
relating to  adjustment  for tax years prior to and  including  the Closing Date
which could  materially  adversely  affect  Innovir and to provide VIMRx and its
representatives such information and records as they may reasonably request with
respect to such adjustments.

     5.7 Governmental  Notification and Approvals. To prepare promptly, file and
diligently pursue with the appropriate  governmental  agencies all documentation
and information  required by law or requested by each such agency to be filed to
permit the consummation of the transactions contemplated hereby.

                                    ARTICLE 6

                         COVENANTS OF VIMRx AND INNOVIR

             VIMRx and Innovir hereby severally covenant and agree:

     6.1 Necessary Assurances. To take, or cause to be taken, all actions and to
do, or cause to be done,  all things  reasonably  necessary or  desirable  under
applicable laws and regulations to consummate the  transactions  contemplated by
this Agreement  expeditiously,  including  executing and delivering such further
documents,  certificates,  applications  and  agreements  as  reasonably  may be
necessary or desirable.

     6.2 Filings and Consents.  To cooperate (i) with respect to any filing with
any governmental body, agency, official or authority required in connection with
this Agreement or the consummation of the transactions  contemplated  hereby and
(ii) with respect to any actions, consents,  approvals or waivers required to be
obtained  from  parties  to any  material  contracts  in  connection  with  this
Agreement or the consummation of the transactions contemplated hereby.

     6.3  Government  Filings.  To make any and all filings  required to be made
with any and all governmental authorities in connection with the consummation of
the transactions  contemplated herein,  including, if required, the notification
required  by the  Hart-Scott-Rodino  Act (the  "HSR" Act) and any  requested  or
supplementary filings thereto in such manner and at such places as are specified
in the HSR Act and the  applicable  rules and  regulations  thereunder,  and any
other notifications to, or filings with, regulatory  authorities.  Innovir shall
pay the fee due in connection with the filing, if required,  of the notification
required  under  the HSR Act;  provided,  however,  that  Innovir  shall  not be
required to pay such fee in the event that such notification relates only to the
transaction  between  Aries and VIMRx  referred to in clause (ii) of Section 9.1
hereof.

                                       44
<PAGE>

     6.4 Public  Announcements.  To consult with each other  before  issuing any
press  release or  otherwise  making any public  statement  with  respect to the
transactions  contemplated  by this  Agreement  and not to issue any such  press
release or make any such  public  statement  without  the prior  approval of the
other party,  except as may be required by any applicable law, rule,  regulation
or regulatory agency requirement.

     6.5  Confidentiality.  To treat as confidential all information  concerning
Innovir (in the case of VIMRx, VHL and the  Subsidiaries) and VIMRx, VHL and the
Subsidiaries  (in  the  case  of  Innovir)   provided  in  connection  with  the
transactions contemplated hereby, except to the extent that such information was
in the public  domain,  prior to the  provision  thereof  to the other  party or
thereafter is in the public  domain other than through the release,  directly or
indirectly, by the party to whom the information was furnished.

     6.6 Expenses. To bear their respective expenses incurred in connection with
the preparation, execution and performance of this Agreement and the transaction
contemplated  hereby,  including  without  limitation,  all fees and expenses of
their  respective  legal  counsel,   financial  advisors,   auditors  and  other
representatives.

                                    ARTICLE 7

                              ADDITIONAL COVENANTS

     7.1 VIMRx Covenants.  VIMRx hereby covenants and agrees (i) to exercise its
warrants to purchase  1,000,000  shares of  Innovir's  Common Stock at $1.00 per
share  within  30 days  after  receipt  of a  written  request  by the  Board of
Directors  of Innovir  subsequent  to May 31, 1997  specifying  that Innovir has
insufficient  funds to continue its operations past 30 days from the date of the
request,  (ii) to pay the costs of the capital  equipment  ordered and listed on
Schedule 2.20 to the extent any payments are due thereon,  and (iii) to vote the
Innovir  Shares and its shares of  Innovir's  Common Stock in favor of the items
specified in sections 7.2 (i) and 7.2 (ii) below.

     7.2 Innovir Covenant. Innovir hereby covenants and agrees, conditional upon
the  closing,  to  convene a meeting  of its  stockholders  to vote upon (i) the
election of five  directors,  three of whom shall be designees of VIMRx,  one of
whom shall not be a VIMRx  director,  officer or employee,  (ii) an amendment to
Innovir's  Certificate of Incorporation to increase its authorized  Common Stock
to  70,000,000  shares and (iii) such  further  specified  action as Innovir and
VIMRx shall agree.

                                       45
<PAGE>

                                    ARTICLE 8

                              CONDITIONS TO CLOSING

     8.1  Conditions  to  Obligations  of Innovir.  The  obligations  of Innovir
hereunder are conditioned upon the following:

               (a) All warranties and representations of VIMRx contained in this
          Agreement  or in any  Schedule or  instrument  delivered  hereunder or
          otherwise made in connection with the transactions contemplated hereby
          shall be true and correct on and as of the Closing Date, with the same
          force and effect as if made on and as of the Closing Date.

               (b) VHL and VIMRx shall have  performed  and complied with all of
          the covenants and agreements required by or pursuant to this Agreement
          and any Schedule or instrument  delivered hereunder to be performed or
          complied with on or prior to the Closing Date.

               (c) No suit, action, investigation or proceeding before or by any
          federal or state court or governmental  or regulatory  authority shall
          have  been  commenced,  and  no  suit,  action  or  proceeding  by any
          governmental  or  regulatory  authority  shall  have been  threatened,
          against  VIMRx,  VHL, any  Subsidiary or Innovir  seeking to restrain,
          prevent  or modify  the  transactions  contemplated  hereby or seeking
          material  damages in connection with any of such  transactions  and no
          order of any court or administrative  agency to restrain,  prohibit or
          nullify the consummation of the transactions contemplated herein shall
          be outstanding as of the Closing Date.

               (d) All  governmental  authorities  having  jurisdiction,  to the
          extent  required  by law,  shall have  consented  to or  approved  the
          consummation of the transactions contemplated by this Agreement.

               (e)  As at the  Closing  Date,  VHL  shall  have  cash  and  cash
          equivalents of $3,000,000 in excess of its stated liabilities.

               (f) As at the Closing Date, The Aries Fund, A Cayman Island Trust
          and The Aries Domestic Fund,  L.P., a Delaware  limited  partnership (
          collectively,  "Aries")  shall  have  exercised  warrants  to  acquire
          6,000,000  shares of Innovir's  Common Stock at an aggregate  exercise
          price of $3,000,000.

               (g) Receipt of the Audited Financial Statements and the September
          30, 1996 Financial Statements.

               (h) All  documents  delivered  and action taken  pursuant  hereto
          shall  be  satisfactory  in form  and  substance  to  Innovir  and its
          counsel.

                                       46
<PAGE>

     8.2 Conditions to Obligations of VIMRx.  The obligations of VIMRx hereunder
are conditioned upon the following:

               (a) All warranties and  representations  of Innovir  contained in
          this Agreement shall be true and correct on and as of the Closing Date
          with the same  force and  effect  as if made on and as of the  Closing
          Date.

               (b) Innovir  shall have  performed  and complied  with all of the
          covenants and agreements required by or pursuant to this Agreement and
          any  Schedule or  instrument  delivered  hereunder  to be performed or
          complied with on or prior to the Closing Date.

               (c) No suit, action, investigation or proceeding before or by any
          federal or state court or governmental  or regulatory  authority shall
          have  been  commenced,  and  no  suit,  action  or  proceeding  by any
          governmental  or  regulatory  authority  shall  have been  threatened,
          against  VIMRx,  VHL, any  Subsidiary or Innovir  seeking to restrain,
          prevent  or modify  the  transactions  contemplated  hereby or seeking
          material  damages in connection with any of such  transactions  and no
          order of any court or administrative agency to restrain,  prohibit, or
          nullify the consummation of the transactions contemplated herein shall
          be outstanding as of the Closing Date.

               (d) All  governmental  authorities  having  jurisdiction,  to the
          extent  required  by law,  shall have  consented  to or  approved  the
          consummation of the transactions contemplated by this Agreement.

               (e) As at the Closing Date,  Aries shall have exercised  warrants
          to acquire  6,000,000 shares of Innovir's Common Stock at an aggregate
          exercise price of $3,000,000.

               (f) All  documents  delivered  and action taken  pursuant  hereto
          shall be satisfactory in form and substance to VIMRx and its counsel.

                                    ARTICLE 9

                                     CLOSING

     9.1 Closing  Date.  The closing of the  transactions  contemplated  by this
Agreement  (the  "Closing")  shall be  conditional  upon and  shall  take  place
concurrently  with the  closing  of (i) the  exercise  by Aries of  warrants  to
purchase  6,000,000  shares of  Innovir's  Common Stock and (ii) the exchange by
Aries with VIMRx of 9,500,000  shares of  Innovir's  Common Stock owned by Aries
for VIMRx Common  Stock,  on December 4, 1996, or such other date as the parties
may fix, (the "Closing  Date") at the offices of Epstein  Becker & Green,  P.C.,
250 Park Avenue, New York, New York 10177-0077.

                                       47
<PAGE>

     9.2 Deliveries by VIMRx. At the Closing, VIMRx shall deliver to Innovir the
following:

               (a) Stock  certificates  for the VHL Shares,  duly  endorsed  for
          transfer to Innovir or its designee and the stock certificates for the
          outstanding shares of the capital stock of the Subsidiaries.

               (b) The minute  book,  stock book and stock ledger of VHL and the
          Subsidiaries.

               (c) A copy of the Certificate of Incorporation of VHL,  certified
          by the appropriate governmental official having authority therefor.

               (d) An agreement  providing for the  provision of  administrative
          and related  services by VIMRx to Innovir and for  submission by VIMRx
          to Innovir of potential licenses and other  arrangements  relating to,
          but limited to, catalytic oligonucleotides, duly executed by VIMRx.

               (e) The written resignations of the directors and officers of VHL
          and the Subsidiaries as requested by Innovir.

               (f) An  officers'  certificate  by the  President  and the  Chief
          Financial  Officer  of VIMRx  confirming  as at the  Closing  Date the
          correctness  of the  warranties  and  representations  of VIMRx in the
          agreement  and  compliance  by  VIMRx  and  VHL of the  covenants  and
          agreements to be performed by them under the agreement.

               (g) The  opinion  of  Epstein  Becker & Green,  P.C.,  counsel to
          VIMRx,  addressed to Innovir,  as to Sections 2.1, 2.2, 2.3 (as to due
          organization  and  subsistence of the  Subsidiaries),  2.18,  2.26 and
          2.27.

     9.3 Deliveries by Innovir. At the Closing,  Innovir shall deliver to VIMRx,
the following:

               (a) Stock  certificates  for the  Innovir  Shares and the Innovir
          Warrants registered in the name of VIMRx.

               (b) An officers'  certificate by the Chief Executive  Officer and
          the Chief  Financial  Officer of Innovir  confirming as at the Closing
          Date the correctness of the warranties and  representations of Innovir
          in the  agreement  and  compliance  by  Innovir of the  covenants  and
          agreements to be performed by Innovir under the agreement.

               (c)  A  Secretary's   certificate   as  to  (i)  the  passage  of
          resolutions  reducing the size of Innovir's Board of Directors to five
          directors,  (ii) the receipt and  acceptance  of written  resignations
          from all directors of Innovir,  other than Dr. Allan  Goldberg and one


                                       48
<PAGE>

          other  director,  and (iii) the  passage of  resolutions  electing  as
          directors of Innovir Richard L. Dunning,  David A. Jackson and a third
          designee of VIMRx who shall not be a director,  officer or employee of
          VIMRx or Innovir.

               (d) An agreement  providing for the  provision of  administrative
          and related  services by VIMRx to Innovir and for  submission by VIMRx
          to Innovir of potential licenses and other  arrangements  relating to,
          but limited to, catalytic oligonucleotides, duly executed by Innovir.

               (e) The  opinion  of  Fullbright  & Jaworski  L.L.P.,  counsel to
          Innovir,  addressed to VIMRx,  as to Sections 3.1, 3.2, 3.4, 3.6, 3.8,
          and 3.9.

                                   ARTICLE 10

                                    SURVIVAL

     10.1 Survival.  All  representations  and warranties made in this Agreement
shall survive the delivery of this Agreement and remain in full force and effect
until December 31, 1997.

                                   ARTICLE 11

                                 INDEMNIFICATION

11.1     Indemnification.

               (a)  Indemnification  by VIMRx.  VIMRx hereby agrees to indemnify
          and  hold  harmless  Innovir  from  and  against  any and all  losses,
          liabilities,  damages,  obligations,  costs and  expenses,  including,
          without  limitation,  amounts paid in settlement and reasonable  costs
          and expenses of  investigating,  preparing to defend and defending any
          claim, action, suit,  proceeding,  inquiry or investigation in respect
          thereof (such losses,  liabilities,  damages,  obligations,  costs and
          expenses as hereinabove set forth, collectively "Damages") incurred by
          Innovir, resulting from, relating to, or arising out of the inaccuracy
          of any representation or warranty herein by VIMRx or the breach of any
          covenant herein by VIMRx.

               (b)   Indemnification  by  Innovir.   Innovir  hereby  agrees  to
          indemnify and hold harmless VIMRx from and against any and all Damages
          incurred by VIMRx resulting  from,  relating to, or arising out of the
          inaccuracy of any  representation or warranty herein by Innovir or the
          breach of any covenant contained herein by Innovir.

               (c) Procedure.  If any action, suit, proceeding or claim shall be
          brought against the party to be indemnified by any third party,  which
          action,  suit,  proceeding or claim,  if  determined  adversely to the
          interest of the party to be  indemnified  and which would  entitle the
          party to be  indemnified  to indemnity  pursuant to this Section 11.1,
          the party to be  indemnified  shall promptly  notify the  indemnifying


                                       49
<PAGE>

          party of the same in writing and, if the indemnifying party so elects,
          the indemnifying party shall assume the defense thereof, including the
          employment of counsel  satisfactory to the party to be indemnified and
          the payment of all reasonable  costs and expenses in respect  thereof.
          The party to be  indemnified  shall  have the right to employ  counsel
          separate from any counsel  employed by the  indemnifying  party in any
          action, suit,  proceeding or claim and to control (or, if the party to
          be indemnified has elected to allow the  indemnifying  party to assume
          the defense thereof,  participate in) the defense thereof and the fees
          and expenses of such counsel  employed by the party to be  indemnified
          shall  be  at  the  expense  of  the  party  to  be  indemnified.  The
          indemnifying  party shall not be liable for any settlement of any such
          action, suit,  proceeding or claim effected without his or its written
          consent  (which shall not be  unreasonably  withheld),  but if settled
          with the written consent of the indemnifying  party, or if there shall
          be a final judgment for plaintiff in any such action, the indemnifying
          party  agrees  to  indemnify   and  hold  harmless  the  party  to  be
          indemnified from and against any loss, liability,  obligation, damage,
          cost or expense by reason of such settlement or judgment.

     11.2 Access.  In the event that Innovir delivers to VIMRx notice of a claim
for indemnification,  Innovir shall provide VIMRx reasonable access to the books
and records of VHL and any  Subsidiary  (and of Innovir in the event Innovir has
possession  of the  requisite  books and  records)  with  respect to any matters
giving rise to such claim.

                                   ARTICLE 12

                            MISCELLANEOUS PROVISIONS

     12.1 Amendment and  Modification.  This Agreement may be amended,  modified
and supplemented only by a writing signed by Innovir and VIMRx.

     12.2 Waiver of  Compliance.  Any failure of Innovir or VIMRx to comply with
any  obligation,  covenant,  agreement  or  condition  herein  contained  may be
expressly  waived, in writing only, by (i) Innovir in the case of any failure of
VIMRx or (ii) VIMRx in the case of any failure of Innovir.  Such waiver shall be
effective only in the specific  instance and for the specific  purpose for which
made or given.

     12.3  Notices.  All  notices,  requests,  demands and other  communications
required or permitted  hereunder shall be in writing and shall be deemed to have
been  duly  given  when  delivered  by hand,  or when  mailed  by  certified  or
registered mail (return receipt requested), postage prepaid or when delivered by
fax (evidenced by confirmation of successful transmission), as follows:

                                       50
<PAGE>

                           A.       If to Innovir:

                                    Innovir Laboratories, Inc.
                                    510 East 73rd Street
                                    New York, New York  10021
                                    Fax # (212) 249-4513
                                    Attn:  Dr. Allan R. Goldberg


                                    With a copy to:

                                    Fullbright & Jaworski L.L.P.
                                    666 Fifth Avenue
                                    New York, New York 10103
                                    Fax # (212) 752-5958
                                    Attn:  Merrill M. Kraines, Esq.

or to such other  person or place as Innovir  shall  designate by notice in
the manner provided in this Section 12.3;



                           B.       If to VIMRx:

                                    VIMRX Pharmaceuticals Inc.
                                    2751 Centerville Road
                                    Wilmington, Delaware 19808
                                    Fax # (302) 998-3794
                                    Attn:  Mr. Richard L. Dunning

                                    With a copy to:

                                    Epstein Becker & Green, P.C.
                                    250 Park Avenue
                                    New York, New York  10177
                                    Fax # (212) 661-0989
                                    Attn:  Lowell Lifschultz, Esq.
 
or to such other  person as VIMRx shall  designate  by notice in the manner
provided in this Section 12.3.

     12.4  Assignment.  This  Agreement  shall be binding  upon and inure to the
benefit  of  Innovir  and its  successors  and  assigns,  and to  VIMRx  and its
successors  and  assigns,  but  neither  this  Agreement  nor any of the rights,
interests and  obligations  hereunder  shall be assigned by either of Innovir or
VIMRx without the prior written consent of the other.

                                       51
<PAGE>

     12.5 Third  Parties.  This  Agreement  is not  intended to and shall not be
construed  to give any Person  other than the  parties  hereto any  interest  or
rights (including,  without limitation, any third party beneficiary rights) with
respect to or in connection with any agreement or provision  contained herein or
contemplated hereby.

     12.6 Governing  Law. This  Agreement  shall be governed by and construed in
accordance with the laws of the State of New York,  without regard to principles
of conflicts of laws.

     12.7  Counterparts.   This  Agreement  may  be  executed  in  two  or  more
counterparts,  each of which shall be deemed an original, but all of which taken
together shall constitute one and the same instrument.

     12.8 Headings. The headings of the sections, schedules and articles of this
Agreement are inserted for the sake of convenience only and shall not constitute
a part hereof.

     12.9  Entire  Agreement.  This  Agreement,   including  the  schedules  and
exhibits,  contains  the entire  understanding  of the parties in respect of the
subject  matter  contained  herein and  therein  and there are no other terms or
conditions,  representations or warranties, written or oral, express or implied,
except as set forth herein.

     IN WITNESS  WHEREOF,  the parties  have caused  this  Agreement  to be duly
executed as of the day and year first above written.


                                        INNOVIR LABORATORIES, INC.


                                        By:  /s/ Alan R. Goldberg          
                                             Dr. Allan R. Goldberg,
                                             Chief Executive Officer



                                        VIMRx PHARMACEUTICALS INC.


                                        By:   /s/ Richard L. Dunning         
                                              Richard L. Dunning, President

                                       52
<PAGE>
                                    Schedules

     The following is a list of schedules  not filed  herewith.  The  Registrant
hereby  agrees  to  supplementally   furnish  to  the  Securities  and  Exchange
Commission a copy of such schedules upon request.


Schedule                      Description
2.5......................     Governmental Authorizations and Other Consents
2.6......................     Non-Contravention
2.8......................     Tangible Property
2.9(b)...................     Leased Real Property
2.10.....................     Intellectual Property
2.13.....................     Permits and Licenses
2.14.....................     Contracts and Agreements
2.15.....................     Employee Benefits
2.16.....................     Accounts Payable
2.17.....................     Liabilities
2.18.....................     Actions and Proceedings
2.19.....................     Bank Accounts, Guarantees and Powers
2.20.....................     Absence of Changes
2.22.....................     Affiliated Transactions
2.25.....................     Employee Compensation
2.29.....................     Insurance
3.3......................     Non-Contravention
3.5......................     Intellectual Property
3.6......................     Actions and Proceedings
3.7......................     Absence of Changes
3.8......................     The Innovir Shares
3.9......................     The Innovir Warrants
3.11.....................     Documents Delivered
5.2......................     Certain Prohibited Activities

                                       53
<PAGE>


                                                            Exhibit 10.17


 
                          REGISTRATION RIGHTS AGREEMENT


     REGISTRATION  RIGHTS  AGREEMENT made on this 23rd day of December 1996 (the
"Agreement")  by and among VIMRx  PHARMACEUTICALS  INC., a Delaware  corporation
(the  "Company"),  the ARIES FUND, a Cayman Island Trust and THE ARIES  DOMESTIC
FUND,  L.P.,  a  Delaware  limited  partnership  (The  Aries  Fund and The Aries
Domestic Fund, L.P., together "The Aries Funds").

     WHEREAS,  pursuant to an Exchange Agreement dated November 21, 1996 by and
among the Company and the Aries Funds,  as amended (the  "Exchange  Agreement"),
the Aries Funds have  acquired from the Company  shares of the Company's  common
stock (the "Shares") which have not been registered  under the Securities Act of
1933 (the "Act"); and

     WHEREAS, the Company has agreed to register the Shares under the Act;

     NOW, THEREFORE, The Aries Funds and the Company hereby agree as follows:

     Section 1. Registration and Indemnification

     1.1. Registration.  The Company shall file, as promptly as possible, but no
later than 45 days from the date hereof,  a registration  statement on Form S-3,
or if  such  form  is not  available,  such  other  applicable  form,  with  the
Securities and Exchange  Commission ("SEC") providing for the sale of the Shares
by  The  Aries  Funds  and  any  successors  and  assigns  as  provided   herein
("Holders");  and shall use its best efforts to cause the registration statement
to be declared  effective as soon as practicable,  and to keep the  registration
statement effective until the earlier of the time the distribution  contemplated
thereby is complete or the time the Shares are  eligible for sale to the public,
pursuant  to Rule 144 under the Act.  In  addition,  the  Company  shall use its
reasonable  best  efforts  to  effect  such  registrations,   qualifications  or
compliances  (including,  without  limitation,  the  execution  of any  required
undertaking to file  post-effective  amendments,  appropriate  qualifications or
exemptions  under  applicable  blue  sky or  other  state  securities  laws  and
appropriate   compliance  with  applicable  securities  laws,   requirements  or
regulations) as may be reasonably  requested,  and as would permit or facilitate
the sale and distribution of all the Shares.

     1.2.  Expenses.  The Company shall pay all expenses in connection  with the
registration rights granted in Section 1.1 including,  without  limitation,  the
fees and  expenses  of the  Company's  counsel  and  accountants,  the costs and
expenses  incident  to the  preparation,  printing,  filing  and  processing  to
effectiveness of the registration  statement,  the costs of furnishing The Aries
Funds with a reasonable number of copies of the Final  Prospectus,  and the fees
and disbursements incurred in qualifying the Shares under applicable blue sky or
securities   laws,  but  shall  not  include  any   underwriting   discounts  or


                                       54
<PAGE>

commissions,  stock  transfer  taxes and fees and  expenses  of counsel  for any
Holders.

     1.3. Agreements of the Holders. (a) Each Holder shall furnish in writing to
the Company all  appropriate  information  reasonably  requested  by the Company
concerning it, in connection  with  preparation  and processing of the requisite
registration  statement  (or  post-effective  amendments  thereto),  including a
shareholder's  questionnaire as to securities held and other matters,  and shall
otherwise reasonably cooperate with the Company in connection therewith.

     (b) Each Holder agrees to deliver a final prospectus to the purchaser(s) of
any Shares sold pursuant to the  registration  statement to be filed pursuant to
Section 1.1 hereof.

     1.4. Indemnification.  (a) With respect to any registration statement which
includes  Shares,  the Company shall indemnify and hold harmless each Holder and
its officers,  directors,  employees, legal counsel, agents, investment managers
and general  partners and each person,  if any, who controls  such Holder within
the meaning of the Securities Act of 1933,  from and against any and all losses,
claims, damages and liabilities,  joint or several, to which any such person may
become  subject  under the  Securities  Act of 1933,  or  otherwise,  caused by,
arising out of or based upon any untrue statement or alleged untrue statement of
a material  fact  contained in such  registration  statement  or  post-effective
amendment or any prospectus  included  therein,  or caused by, arising out of or
based upon the  omission or alleged  omission to state  therein a material  fact
required to be stated  therein or necessary to make the  statements  therein not
misleading,  and to reimburse  any such persons for any legal or other  expenses
reasonably incurred in connection with investigating or defending any such loss,
claim,  damage,  liability or action,  except  insofar as such  losses,  claims,
damages, or liabilities arise out of or are based upon any such untrue statement
or  alleged  untrue  statement  or  omission  or  alleged  omission,  based upon
information  furnished  in writing to the Company by the Aries Funds or any such
Holder,  expressly  for use in such  registration  statement  or  post-effective
amendment.

     (b) Each Holder shall  indemnify  the  Company,  its  directors,  officers,
employees,  legal  counsel,  agents,  and each person,  if any, who controls the
Company  within the meaning of the  Securities  Act of 1933 from and against any
and all losses, claims, damages and liabilities, joint and several, to which the
Company or any such person may become  subject under the Securities Act of 1933,
or otherwise,  caused by,  arising out of or based upon any untrue  statement or
alleged  untrue  statement of a material  fact  contained  in such  registration
statement or post-effective  amendment or any prospectus  included  therein,  or
caused by,  arising  out of or based upon the  omission  or alleged  omission to
state therein a material fact required to be stated therein or necessary to make


                                       55
<PAGE>

the  statements  therein not  misleading,  and to reimburse the Company and each
such person for any legal or other  expenses  reasonably  incurred in connection
with  investigating  or defending  any such loss,  claim,  damage,  liability or
action,  but only to the extent that such  untrue  statement  or alleged  untrue
statement,  omission or alleged omission is caused by, arises out of or is based
upon  information  furnished in writing to the Company by such Holder  expressly
for  use  in  such  registration  statement  or  post-effective  amendment.  The
foregoing  notwithstanding,  no Holder shall be liable hereunder in an amount in
excess of the gross  proceeds  received  by it as a result of sale of the Shares
pursuant to the Registration Statement.

     (c) If the  indemnification  provided  for in this Section 1.4 is held by a
court of competent  jurisdiction to be unavailable to an indemnified  party with
respect to any loss,  liability,  claim,  damage or expense referred to therein,
then the  indemnifying  party, in lieu of indemnifying  such  indemnified  party
thereunder,  shall  contribute to the amount paid or payable by such indemnified
party as a result of such  loss,  liability,  claim,  damage or  expense in such
proportion as is appropriate  to reflect the relative fault of the  indemnifying
party on the one hand and of the  indemnified  party on the other in  connection
with the statements or omissions which resulted in such loss, liability,  claim,
damage or expense as well as any other relevant  equitable  considerations.  The
relative fault of the indemnifying  party and of the indemnified  party shall be
determined by reference  to, among other  things,  whether the untrue or alleged
untrue  statement of a material  fact or the  omission to state a material  fact
relates to information  supplied by the indemnifying party or by the indemnified
party and the parties'  relative  intent,  knowledge,  access to information and
opportunity to correct or prevent such statement or omission.

     1.5.  Information  and  Cooperation.  In  the  case  of  the  registration,
qualification,  exemption or compliance effected by the Company pursuant to this
Agreement,  the Company will, upon reasonable request,  inform each Holder as to
the status of such registration, qualification, exemption and compliance. At its
expense the Company:

     (a) will advise the Holders:

     (i) when the Registration Statement or any amendment thereto has been filed
with the Commission and when the  Registration  Statement or any  post-effective
amendment thereto has become effective;

     (ii) of any request by the  Commission for amendments or supplements to the
Registration  Statement or the  prospectus  included  therein or for  additional
information;

                                       56
<PAGE>

     (iii) of the issuance by the  Commission of any stop order  suspending  the
effectiveness of the Registration Statement or the initiation of any proceedings
for such purpose;

     (iv) of the receipt by the Company of any notification  with respect to the
suspension of the qualification of the Registrable  Securities  included therein
for sale in any jurisdiction, or the initiation or threatening of any proceeding
for such purpose; and

     (v) of the  happening of any event that  requires the making of any changes
in the  Registration  Statement or the  prospectus so that, as of such date, the
statements therein are not misleading,  and do not omit to state a material fact
required to be stated  therein or necessary to make the  statements  therein (in
the case of the prospectus,  in the light of the circumstances  under which they
were made) not misleading;

     (b) will make every reasonable effort to obtain the withdrawal of any order
suspending  the  effectiveness  of any  Registration  Statement  at the earliest
possible time;

     (c) will furnish to each Holder,  without charge, at least one copy of such
Registration  Statement  and any  post-effective  amendment  thereto,  including
financial  statements and schedules,  and, if the Holder so requests in writing,
all exhibits  (including those incorporated by reference) in the form filed with
the Commission;

     (d) during the Registration  Period,  will deliver to each Holder,  without
charge, as many copies of the prospectus included in such Registration Statement
and any amendment or supplement  thereto as such Holder may reasonably  request;
and the Company consents to the use,  consistent with the provisions  hereof, of
the  prospectus or any  amendment or  supplement  thereto by each of the selling
Holders of  Registrable  Securities in connection  with the offering and sale of
the  Registrable  Securities  covered  by the  prospectus  or any  amendment  or
supplement thereto.  In addition,  upon the reasonable request of the Holder and
subject in all cases to confidentiality protections reasonably acceptable to the
Company, the Company will meet with a Holder or a representative  thereof at the
Company's headquarters to discuss all information relevant for disclosure in the
Registration Statement covering the Registrable  Securities,  and will otherwise
cooperate  with any  Holder  conducting  an  investigation  for the  purpose  of
reducing or  eliminating  such  Holder's  exposure to  liability  under the Act,
including   the   reasonable   production  of   information   at  the  Company's
headquarters;

     (e) during the registration  period,  will deliver to each Holder,  without
charge,  (i) as soon as practicable (but in the case of the annual report of the
Company to its  stockholders,  within 120 days after the end of each fiscal year
of the Company) one copy of: (A) its annual report to its  stockholders,  if any


                                       57
<PAGE>

(which annual report shall contain  financial  statements  audited in accordance
with generally accepted accounting principles in the United States of America by
a firm of certified  public  accountants  of  recognized  standing);  (B) if not
included in substance in its annual report to stockholders, its annual report on
Form  10-K  (or  similar  form);  (C)  each  of  its  quarterly  reports  to its
stockholders,  and, if not  included in substance  in its  quarterly  reports to
stockholders,  its quarterly  report on Form 10-Q (or similar  form);  and (D) a
copy of the full Registration Statement (the foregoing,  in each case, excluding
exhibits);  and (ii) upon  reasonable  request,  all  exhibits  excluded  by the
parenthetical to the immediately preceding clause (D), and all other information
that is generally available to the public;

     (f) prior to any public  offering of Shares  pursuant  to any  Registration
Statement,  will  register or qualify or obtain an exemption  for offer and sale
under the securities or blue sky laws of such  jurisdictions as any such Holders
reasonably request in writing,  provided that the Company shall not for any such
purpose be  required  to qualify  generally  to  transact  business as a foreign
corporation in any jurisdiction  where it is not so qualified,  or to consent to
general  service of process  in any such  jurisdiction,  and will do any and all
other acts or things  reasonably  necessary or advisable to enable the offer and
sale in such jurisdictions of the Shares covered by such Registration Statement;

     (g) will cooperate  with the Holders to facilitate  the timely  preparation
and  delivery  of  certificates   representing   Shares  sold  pursuant  to  any
Registration  Statement,  free of any  restrictive  legends  to the  extent  not
required at such time and in such  denominations and registered in such names as
Holders may request.

     (h) upon the  occurrence  of any event  contemplated  by Section  1.5(b)(v)
above,  shall promptly  prepare a  post-effective  amendment to the Registration
Statement or a supplement to the related prospectus,  or file any other required
document so that, as thereafter  delivered to purchasers of the Shares  included
therein, the prospectus will not include any untrue statement of a material fact
or omit to state any material fact necessary to make the statements  therein, in
the light of the circumstances under which they were made, not misleading; and

     (i) will use its best  efforts  to  comply  with all  applicable  rules and
regulations of the Commission,  and will make generally available to the Holders
not later  than 45 days (or 90 days if the fiscal  quarter is the fourth  fiscal
quarter) after the end of its fiscal quarter in which the first anniversary date
of the  effective  date  of  the  Registration  Statement  occurs,  an  earnings
statement satisfying the provisions of Section 11(a) of the Act.

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     1.6. Rule 144. With a view to making  available to the Holders the benefits
of certain rules and regulations of the Commission  which at any time permit the
sale of the Shares to the public without registration, the Company agrees to use
it reasonable best efforts to:

     (a)  make  and keep  public  information  available,  as  those  terms  are
understood and defined in Rule 144 under the Act, at all times;

     (b) file with the  Commission  in a timely  manner  all  reports  and other
documents required of the Company under the Exchange Act; and

     (c) so long as a  Holder  owns any  unregistered  Shares,  furnish  to such
Holder upon any reasonable  request a written statement by the Company as to its
compliance  with Rule 144 under the Act, and of the Exchange  Act, a copy of the
most recent  annual or quarterly  report of the Company,  and such other reports
and documents of the Company as such Holder may  reasonably  request in availing
itself of any rule or regulation of the Commission allowing a Holder to sell any
such securities without registration.


     Section 2. Notices. Any notice pursuant to this Agreement by the Company or
by The Aries  Funds  shall be in  writing  and shall be deemed to have been duly
given if delivered or mailed by certified mail five days after  mailing,  return
receipt requested:

                  If to The Aries Funds:

                           The Aries Trust or the Aries Domestic Fund, L.P.
                           c/o Paramount Capital Asset Management, Inc.
                           787 Seventh Avenue
                           New York, New York  10019
                           Fax No.: (212) 554-4490
                           Attn:  David Walner

                  If to the Company:

                           VIMRx Pharmaceuticals Inc.
                           2751 Centerville Road
                           Wilmington, Delaware  19808
                           Fax No.: (302) 998-3794
                           Attn:  Mr. Richard L. Dunning

                  with a copy to:

                           Lowell S. Lifschultz, Esq.
                           Epstein Becker & Green, P.C.
                           250 Park Avenue - 12th Floor
                           New York, New York  10177

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     Each party hereto may from time to time change the address to which notices
to it are to be delivered or mailed  hereunder by notice in accordance  herewith
to the other party.

     Section  3.  Successors.  All of  the  covenants  and  provisions  of  this
Agreement by or for the benefit of the Company or The Aries Funds shall bind and
inure to the benefit of their respective  successors and assigns  hereunder.  No
such  assignee may claim rights  under  Section 1 hereof  without at the time of
such claim agreeing to be bound by the provisions thereof.

     Section 4.  Applicable Law. This Agreement shall be deemed to be a contract
made  under  the laws of the  State of New  York and for all  purposes  shall be
construed in accordance with the internal laws of said state.

     Section 5. Benefits of this  Agreement.  Nothing in this Agreement shall be
construed  to give to any person or  corporation  other than the Company and The
Aries Funds and their  respective  successors and assigns any legal or equitable
right, remedy or claim under this Agreement, and this Agreement shall be for the
sole and  exclusive  benefit  of the  Company  and The  Aries  Funds  and  their
respective successors and assigns.

     IN WITNESS  WHEREOF,  the parties  have caused  this  Agreement  to be duly
executed, all as of the day and year set forth below.

                                       VIMRx PHARMACEUTICALS, INC.



                                       By: /s/ Francis M. O'Connell       
                                           Francis M. O'Connell
                                           Chief Financial Officer


                                       THE ARIES FUND, A CAYMAN ISLAND TRUST

                                       By:  its Investment Manager,
                                            PARAMOUNT CAPITAL ASSET
                                            MANAGEMENT, INC.



                                       By: /s/ Lindsay A. Rosenwald, M.D. 
                                           Lindsay A. Rosenwald, M.D.,
                                           President


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                                       THE ARIES DOMESTIC FUND, L.P.

                                       By:  its General Partner,
                                            PARAMOUNT CAPITAL ASSET
                                            MANAGEMENT, INC.



                                        By: /s/ Lindsay A. Rosenwald, M.D. 
                                            Lindsay A. Rosenwald, M.D.,
                                            President


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