NEXELL THERAPEUTICS INC
SC 13G, 1999-12-20
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549




                              INITIAL SCHEDULE 13G




                    Under the Securities Exchange Act of 1934



                            Nexell Therapeutics, Inc.
- --------------------------------------------------------------------------------
                                (Name of Issuer)
                                  Common Stock
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)
                                    65332H104
- --------------------------------------------------------------------------------
                                 (CUSIP Number)

                                November 24, 1999
- --------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:


                [ X ]      Rule 13d-1(b)

                [   ]      Rule 13d-1(c)

                [   ]      Rule 13d-1(d)


*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).







                                PAGE 1 OF 4 PAGES

<PAGE>

<TABLE>
<CAPTION>

                  <S>                                      <C>                                       <C>
- -----------------------------------------                                        --------------------------------------
CUSIP No.   65332H104                                      13G                   Page  2  of  4  Pages
- -----------------------------------------                                        --------------------------------------

- ---------- -------------------------------------------------------------------------------------------------------------
    1      NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           John Hancock Mutual Life Insurance Company
           I.R.S. No. 04-1414660

- ---------- -------------------------------------------------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                      (a)  |_|
                                                                                  (b)  |_|
           N/A

- ---------- -------------------------------------------------------------------------------------------------------------
    3      SEC USE ONLY

- ---------- -------------------------------------------------------------------------------------------------------------
    4      CITIZENSHIP OR PLACE OF ORGANIZATION

           Commonwealth of Massachusetts

- ---------- -------------------------------------------------------------------------------------------------------------
                       5     SOLE VOTING POWER
    Number of
      Shares                 13,571,428

                    -------- -------------------------------------------------------------------------------------------
   Beneficially        6     SHARED VOTING POWER
     Owned by
       Each                  -0-

                    -------- -------------------------------------------------------------------------------------------
    Reporting          7     SOLE DISPOSITIVE POWER
      Person
       With                  13,571,428

                    -------- -------------------------------------------------------------------------------------------
                       8     SHARED DISPOSITIVE POWER

                             -0-

- ---------- -------------------------------------------------------------------------------------------------------------
    9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           13,571,428

- ---------- -------------------------------------------------------------------------------------------------------------
   10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

           N/A

- ---------- -------------------------------------------------------------------------------------------------------------
   11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           18.7%

- ---------- -------------------------------------------------------------------------------------------------------------
   12      TYPE OF REPORTING PERSON*

           IC, IA

- ---------- -------------------------------------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!
                                PAGE 2 OF 4 PAGES
</TABLE>



<PAGE>


         The original statement shall be signed by each person on whose behalf
the statement is filed or his authorized representative. If the statement is
signed on behalf of a person by his authorized representative other than an
executive officer or general partner of the filing person, evidence of the
representative's authority to sign on behalf of such person shall be filed with
the statement, provided, however, that a power of attorney for this purpose
which is already on file with the Commission may be incorporated by reference.
The name and any title of each person who signs the statement shall be typed or
printed beneath his signature.

Note: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See Sec. 240.13d-7 for other
parties for whom copies are to be sent.

         Attention: Intentional misstatements or omissions of fact constitute
Federal criminal violations (See 18 U.S.C. 1001)

         Item 1(a)    Name of Issuer:
                      Nexell Therapeutics, Inc.

         Item 1(b)    Address of Issuer's Principal Executive Offices:
                      9 Parker Avenue
                      Irvine, CA 92618

         Item 2(a)    Name of Person Filing:
                      This filing is made on behalf of John Hancock Mutual Life
                      Insurance Company ("JHMLICO").

         Item 2(b)    Address of the Principal Offices:
                      The principal business office of JHMLICO is located at
                      John Hancock Place, P.O. Box 111, Boston, MA 02117.

         Item 2(c)    Citizenship:
                      JHMLICO is organized and exists under the laws of the
                      Commonwealth of Massachusetts.

         Item 2(d)    Title of Class of Securities:
                      Common Stock

         Item 2(e)    CUSIP Number:
                      65332H104

         Item 3       If the Statement is being filed  pursuant to Rule
                      13d-1(b), or 13d-2(b), check whether the person filing is
                      a:

                      JHMLICO:      (c) (X) Insurance Company as defined in
                                            ss.3(a)(19) of the Act.

                                    (e) (X) Investment Adviser registered
                                            under ss.203 of the Investment
                                            Advisers Act of 1940.

         Item 4       Ownership:

                      (a)    Amount Beneficially Owned: JHMLICO has direct
                             beneficial ownership of 13,571,428 shares of
                             Common Stock through beneficial ownership of
                             Series B Cumulative Preferred Stock and Class B
                             Warrants.

                             33,000 are shares of Series B Cumulative Preferred
                             Stock convertible into 12,000,000 shares of Common
                             Stock. Of the 12,000,000 shares, 10,909,091 are
                             owned by JHMLICO, 727,273 shares are owned by
                             JHMLICO's direct wholly-owned subsidiary John
                             Hancock Variable Life Insurance Company
                             ("JHVLICO"), and 363,636 shares are owned by
                             JHVLICO's direct wholly-owned subsidiary Investors
                             Partner Life Insurance Company ("Partners").



                                PAGE 3 OF 4 PAGES


<PAGE>


                             1,571,428 are Class B Warrants exercisable
                             immediately into Common Stock. Of the 1,571,428
                             shares 1,428,571 are owned by JHMLICO, 95,238
                             shares are owned by JHMLICO's direct wholly-owned
                             subsidiary John Hancock Variable Life Insurance
                             Company ("JHVLICO"), and 47,619 shares are owned by
                             Investors  Partner Life Insurance Company
                             ("Partners").

                      (b)    Percent of Class:  18.7%

                      (c)    (i)    sole power to vote or to direct the
                                    vote: JHMLICO has sole power to vote or to
                                    direct the vote of the 13,571,428 shares as
                                    discussed in Item 4(a) above.

                             (ii)   shared power to vote or to direct the
                                    vote:  -0-

                             (iii)  sole power to dispose or to direct the
                                    disposition:  JHMLICO has sole power to
                                    dispose or to direct the disposition of the
                                    13,571,428 shares as discussed in Item
                                    4(a) above.

                             (iv)   shared power to dispose or to direct the
                                    disposition of:     -0-

         Item 5       Ownership of Five Percent or Less of a Class:
                      Not applicable.

         Item 6       Ownership of More than Five Percent on Behalf of Another
                      Person:
                      Not applicable.

         Item 7       Identification and Classification of the Subsidiary
                      which Acquired the Security Being Reported on by the
                      Parent Holding Company:
                      Not applicable.

         Item 8       Identification and Classification of Members of the Group:
                      Not applicable.

         Item 9       Notice of Dissolution of a Group:
                      Not applicable.

         Item 10      Certification:
                      By signing below the undersigned certifies that, to the
                      best of its knowledge and belief, the securities referred
                      to above were acquired in the ordinary  course of business
                      and were not acquired for the purpose of and do not have
                      the effect of changing or influencing the control of the
                      issuer of such securities and were not acquired in
                      connection with or as a participant in any transaction
                      having such purpose or effect.


                                    SIGNATURE

         After reasonable inquiry and to the best of its knowledge and belief,
each of the undersigned certifies that the information set forth in this
statement is true, complete and correct.

                              John Hancock Mutual Life Insurance Company

                              By:      /s/Roger G. Nastou
                                       ------------------
                              Name:    Roger G. Nastou
Dated: December 20, 1999      Title:   Vice President

                                PAGE 4 OF 4 PAGES





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